COL7A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)9.21042868
2protein heterotrimerization (GO:0070208)7.28800924
3desmosome organization (GO:0002934)6.21467281
4wound healing, spreading of epidermal cells (GO:0035313)5.61125980
5collagen fibril organization (GO:0030199)5.55344563
6hair cycle (GO:0042633)5.54002201
7molting cycle (GO:0042303)5.54002201
8skin morphogenesis (GO:0043589)5.51975657
9bone trabecula formation (GO:0060346)5.32009118
10establishment of skin barrier (GO:0061436)5.24149386
11regulation of water loss via skin (GO:0033561)5.05567090
12cell-substrate junction assembly (GO:0007044)4.98551579
13* collagen metabolic process (GO:0032963)4.88408418
14* collagen catabolic process (GO:0030574)4.86881289
15planar cell polarity pathway involved in neural tube closure (GO:0090179)4.86838672
16wound healing, spreading of cells (GO:0044319)4.66605462
17anatomical structure regression (GO:0060033)4.63573158
18extracellular fibril organization (GO:0043206)4.58775040
19* multicellular organismal catabolic process (GO:0044243)4.57528261
20regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.56444933
21* multicellular organismal macromolecule metabolic process (GO:0044259)4.56063642
22bundle of His cell to Purkinje myocyte communication (GO:0086069)4.54115968
23outer ear morphogenesis (GO:0042473)4.39833900
24* extracellular matrix disassembly (GO:0022617)4.37915082
25* multicellular organismal metabolic process (GO:0044236)4.37230273
26* endodermal cell differentiation (GO:0035987)4.32112781
27lung-associated mesenchyme development (GO:0060484)4.25675162
28positive regulation of endothelial cell apoptotic process (GO:2000353)4.10294951
29polarized epithelial cell differentiation (GO:0030859)4.02649807
30dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.00148413
31atrioventricular valve morphogenesis (GO:0003181)3.99078609
32skin development (GO:0043588)3.94946946
33fibril organization (GO:0097435)3.94123643
34negative regulation of fatty acid transport (GO:2000192)3.92340049
35chondrocyte proliferation (GO:0035988)3.86257525
36cell-substrate adherens junction assembly (GO:0007045)3.84177508
37focal adhesion assembly (GO:0048041)3.84177508
38negative regulation of keratinocyte proliferation (GO:0010839)3.74341453
39keratinization (GO:0031424)3.69752473
40lateral sprouting from an epithelium (GO:0060601)3.67999455
41keratinocyte proliferation (GO:0043616)3.63628097
42non-canonical Wnt signaling pathway (GO:0035567)3.61573009
43eyelid development in camera-type eye (GO:0061029)3.59582294
44Golgi transport vesicle coating (GO:0048200)3.58245951
45COPI coating of Golgi vesicle (GO:0048205)3.58245951
46epithelial cell-cell adhesion (GO:0090136)3.55356111
47hypotonic response (GO:0006971)3.54526912
48pattern specification involved in kidney development (GO:0061004)3.52495559
49protein localization to endosome (GO:0036010)3.49822977
50semaphorin-plexin signaling pathway (GO:0071526)3.49780532
51cell adhesion mediated by integrin (GO:0033627)3.49528430
52endothelial cell chemotaxis (GO:0035767)3.49157005
53renal filtration (GO:0097205)3.47998271
54peptide cross-linking (GO:0018149)3.47083377
55G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.40035718
56positive regulation of blood vessel endothelial cell migration (GO:0043536)3.38058736
57establishment of apical/basal cell polarity (GO:0035089)3.34733614
58establishment of tissue polarity (GO:0007164)3.33701101
59establishment of planar polarity (GO:0001736)3.33701101
60axon extension involved in axon guidance (GO:0048846)3.32813502
61neuron projection extension involved in neuron projection guidance (GO:1902284)3.32813502
62regulation of hippo signaling (GO:0035330)3.32398470
63sequestering of extracellular ligand from receptor (GO:0035581)3.30663952
64maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.29443203
65basement membrane organization (GO:0071711)3.28990437
66mesenchyme morphogenesis (GO:0072132)3.26113961
67negative regulation of chondrocyte differentiation (GO:0032331)3.24583433
68regulation of endothelial cell chemotaxis (GO:2001026)3.23115701
69Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.23083073
70tooth mineralization (GO:0034505)3.22378832
71positive regulation of epithelial to mesenchymal transition (GO:0010718)3.21930502
72craniofacial suture morphogenesis (GO:0097094)3.20673008
73multicellular organismal water homeostasis (GO:0050891)3.20063833
74stress fiber assembly (GO:0043149)3.18493471
75negative regulation of cell fate specification (GO:0009996)3.18000908
76mesodermal cell differentiation (GO:0048333)3.17115382
77branching involved in salivary gland morphogenesis (GO:0060445)3.16552905
78adhesion of symbiont to host cell (GO:0044650)3.16082578
79virion attachment to host cell (GO:0019062)3.16082578
80cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.15732192
81surfactant homeostasis (GO:0043129)3.14649289
82endocardial cushion morphogenesis (GO:0003203)3.14461204
83head development (GO:0060322)3.12759419
84regulation of establishment of planar polarity (GO:0090175)3.11702345
85protein retention in ER lumen (GO:0006621)3.11084823
86proximal/distal pattern formation (GO:0009954)3.10051053
87negative regulation of embryonic development (GO:0045992)3.09895473
88regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.08948952
89cellular response to vitamin D (GO:0071305)3.04866983
90negative regulation of cartilage development (GO:0061037)3.02935949
91renal system development (GO:0072001)3.01428014
92peptidyl-proline hydroxylation (GO:0019511)2.99387589
93* epidermis development (GO:0008544)2.98686182
94embryonic camera-type eye development (GO:0031076)2.98400547
95cochlea morphogenesis (GO:0090103)2.98265680
96regulation of hair follicle development (GO:0051797)2.97231597
97cellular response to vitamin (GO:0071295)2.97015734
98regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.96398729
99apoptotic process involved in morphogenesis (GO:0060561)2.96061650
100regulation of apoptotic process involved in morphogenesis (GO:1902337)2.95417264
101cell junction assembly (GO:0034329)2.94965457
102keratinocyte differentiation (GO:0030216)2.94393257
103activation of Rac GTPase activity (GO:0032863)2.93573837
104epithelial cell fate commitment (GO:0072148)2.93149036
105plasma membrane repair (GO:0001778)2.91766322
106cytoskeletal anchoring at plasma membrane (GO:0007016)2.91165909
107substrate-dependent cell migration (GO:0006929)2.89895824
108intermediate filament organization (GO:0045109)2.88758712
109vascular endothelial growth factor signaling pathway (GO:0038084)2.87019509
110hippo signaling (GO:0035329)2.86664515
111embryonic cranial skeleton morphogenesis (GO:0048701)2.85761998
112regulation of gastrulation (GO:0010470)2.85416117
113cellular response to amino acid stimulus (GO:0071230)2.84330555
114protein hydroxylation (GO:0018126)2.83899077
115negative regulation of axon extension involved in axon guidance (GO:0048843)2.82230455
116cell junction organization (GO:0034330)2.81884792
117positive regulation of osteoblast proliferation (GO:0033690)2.81195765
118endothelial cell morphogenesis (GO:0001886)2.80794350
119vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.80391788
120paraxial mesoderm development (GO:0048339)2.78841973
121mesenchymal-epithelial cell signaling (GO:0060638)2.78679704
122adhesion of symbiont to host (GO:0044406)2.78307006
123axis elongation (GO:0003401)2.78078125
124establishment or maintenance of monopolar cell polarity (GO:0061339)2.77769160
125establishment of monopolar cell polarity (GO:0061162)2.77769160
126cell proliferation involved in metanephros development (GO:0072203)2.77428549
127regulation of plasminogen activation (GO:0010755)2.77066921
128adherens junction assembly (GO:0034333)2.76927852
129bone morphogenesis (GO:0060349)2.76865465
130glial cell migration (GO:0008347)2.76214041
131extracellular matrix assembly (GO:0085029)2.75591119
132odontogenesis (GO:0042476)2.75340134
133negative regulation of catenin import into nucleus (GO:0035414)2.72292183
134ectoderm development (GO:0007398)2.72219300
135glomerular basement membrane development (GO:0032836)2.68595878
136actin filament depolymerization (GO:0030042)2.65862289
137* extracellular matrix organization (GO:0030198)2.65219576
138cell migration involved in sprouting angiogenesis (GO:0002042)2.64609805
139* extracellular structure organization (GO:0043062)2.64201060
140regulation of keratinocyte proliferation (GO:0010837)2.62250655
141regulation of transforming growth factor beta2 production (GO:0032909)2.60597040
142wound healing (GO:0042060)2.58512599
143branching involved in mammary gland duct morphogenesis (GO:0060444)2.56826000
144lung vasculature development (GO:0060426)2.53951079
145adherens junction organization (GO:0034332)2.53847754
146morphogenesis of embryonic epithelium (GO:0016331)2.53570691
147endocytic recycling (GO:0032456)2.52623079
148midgut development (GO:0007494)2.51606754
149regulation of early endosome to late endosome transport (GO:2000641)2.51596668

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.32454669
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.52678118
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.11683005
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.68571669
5ZNF263_19887448_ChIP-Seq_K562_Human2.65990333
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.42819345
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.24796422
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.13788735
9SOX9_24532713_ChIP-Seq_HFSC_Mouse2.03391896
10TP63_17297297_ChIP-ChIP_HaCaT_Human11.9737391
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.99328578
12* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.96670739
13CLOCK_20551151_ChIP-Seq_293T_Human1.91607149
14ELK3_25401928_ChIP-Seq_HUVEC_Human1.90637842
15WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.90287785
16RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.88328522
17P63_26484246_Chip-Seq_KERATINOCYTES_Human1.87245243
18ESR1_21235772_ChIP-Seq_MCF-7_Human1.85304836
19RACK7_27058665_Chip-Seq_MCF-7_Human1.77179707
20UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.73793616
21TP53_20018659_ChIP-ChIP_R1E_Mouse1.72589562
22KDM2B_26808549_Chip-Seq_SUP-B15_Human1.72311829
23LXR_22292898_ChIP-Seq_THP-1_Human1.71359799
24EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.70143981
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.66133940
26KDM2B_26808549_Chip-Seq_K562_Human1.65160179
27* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.63046438
28* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.63046438
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62693141
30ZFP281_18757296_ChIP-ChIP_E14_Mouse1.59209979
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.53882850
32ATF3_27146783_Chip-Seq_COLON_Human1.50567576
33KDM2B_26808549_Chip-Seq_DND41_Human1.47047174
34KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.46200976
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45069284
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.44987653
37P300_27058665_Chip-Seq_ZR-75-30cells_Human1.42403806
38RUNX1_27514584_Chip-Seq_MCF-7_Human1.42233313
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.38706785
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.38706785
41UBF1/2_26484160_Chip-Seq_HMECs_Human1.38084488
42ZFP281_27345836_Chip-Seq_ESCs_Mouse1.36462922
43CJUN_26792858_Chip-Seq_BT549_Human1.36388283
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34855281
45KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34751527
46CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.33089487
47KDM2B_26808549_Chip-Seq_JURKAT_Human1.31279926
48* ERG_21242973_ChIP-ChIP_JURKAT_Human1.29413281
49KLF5_25053715_ChIP-Seq_YYC3_Human1.28070225
50HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.27501578
51KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27203634
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25918723
53SMC4_20622854_ChIP-Seq_HELA_Human1.25641730
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25472427
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22709996
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.21809561
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20905345
58* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.20122344
59TP53_22127205_ChIP-Seq_IMR90_Human1.20031214
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.18417467
61SA1_27219007_Chip-Seq_ERYTHROID_Human1.17073888
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16468019
63SMC1_22415368_ChIP-Seq_MEFs_Mouse1.15747988
64ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.15575206
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.13908674
66CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12218982
67* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10557519
68TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10474029
69* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10412666
70* TP63_22573176_ChIP-Seq_HFKS_Human1.08925369
71EZH2_27304074_Chip-Seq_ESCs_Mouse1.08838580
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08265589
73* TET1_21490601_ChIP-Seq_MESCs_Mouse1.08211515
74TCF7_22412390_ChIP-Seq_EML_Mouse1.08189130
75BRD4_25478319_ChIP-Seq_HGPS_Human1.07486786
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06463192
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05920383
78ISL1_27105846_Chip-Seq_CPCs_Mouse1.05171358
79TP53_23651856_ChIP-Seq_MEFs_Mouse1.03303335
80NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03214091
81NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02476889
82* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02199950
83GATA2_21666600_ChIP-Seq_HMVEC_Human1.01265853
84ESR1_20079471_ChIP-ChIP_T-47D_Human1.00000211
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99764610
86PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.99198970
87CREB1_26743006_Chip-Seq_LNCaP_Human0.99191196
88SOX2_20726797_ChIP-Seq_SW620_Human0.99015153
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98472876
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98269758
91RING1B_27294783_Chip-Seq_NPCs_Mouse0.97918295
92VDR_21846776_ChIP-Seq_THP-1_Human0.97763984
93DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97463978
94TP53_18474530_ChIP-ChIP_U2OS_Human0.97072326
95* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95995738
96CTCF_27219007_Chip-Seq_Bcells_Human0.95946592
97SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95840563
98EZH2_27294783_Chip-Seq_ESCs_Mouse0.95712089
99MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95088318
100TBX20_22328084_ChIP-Seq_HEART_Mouse0.92844785
101TBX20_22080862_ChIP-Seq_HEART_Mouse0.92844785
102* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91972029
103SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91882219
104CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91769366
105SMC3_22415368_ChIP-Seq_MEFs_Mouse0.91724770
106SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.91411517
107P68_20966046_ChIP-Seq_HELA_Human0.91128791
108TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90831319
109KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90339883
110SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90289531
111SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.88802227
112ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88629475
113TP53_16413492_ChIP-PET_HCT116_Human0.88205017
114WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87430584
115ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87330204
116DROSHA_22980978_ChIP-Seq_HELA_Human0.86458559
117KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86259895
118EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.86062369
119THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85759224
120RING1B_27294783_Chip-Seq_ESCs_Mouse0.85219672
121JARID2_20064375_ChIP-Seq_MESCs_Mouse0.85076393
122NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.84894344
123TET1_21451524_ChIP-Seq_MESCs_Mouse0.84668328
124POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.84352474
125FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.83929324
126SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83847987
127NFIB_24661679_ChIP-Seq_LUNG_Mouse0.83186955

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.31773914
2MP0005275_abnormal_skin_tensile6.11661361
3MP0003705_abnormal_hypodermis_morpholog4.76733016
4* MP0002060_abnormal_skin_morphology3.21617805
5MP0010234_abnormal_vibrissa_follicle3.11115884
6MP0002796_impaired_skin_barrier2.76571865
7MP0004272_abnormal_basement_membrane2.65337926
8MP0005503_abnormal_tendon_morphology2.63797394
9MP0010030_abnormal_orbit_morphology2.55220393
10* MP0001243_abnormal_dermal_layer2.47102840
11MP0000383_abnormal_hair_follicle2.33150479
12MP0006054_spinal_hemorrhage2.28884175
13MP0003566_abnormal_cell_adhesion2.06546134
14MP0010678_abnormal_skin_adnexa2.04472347
15MP0001958_emphysema2.03081072
16MP0000467_abnormal_esophagus_morphology2.02491919
17* MP0000579_abnormal_nail_morphology1.95846746
18MP0010352_gastrointestinal_tract_polyps1.95601610
19MP0003941_abnormal_skin_development1.90020025
20MP0002234_abnormal_pharynx_morphology1.89724042
21MP0005501_abnormal_skin_physiology1.89361217
22MP0005257_abnormal_intraocular_pressure1.89245311
23* MP0001216_abnormal_epidermal_layer1.88816141
24MP0005623_abnormal_meninges_morphology1.78692748
25MP0003279_aneurysm1.78672782
26MP0002254_reproductive_system_inflammat1.78424508
27* MP0010771_integument_phenotype1.76251547
28MP0002098_abnormal_vibrissa_morphology1.75638821
29* MP0000762_abnormal_tongue_morphology1.70621043
30MP0009053_abnormal_anal_canal1.70400271
31MP0003453_abnormal_keratinocyte_physiol1.62622997
32MP0001849_ear_inflammation1.61136232
33MP0000377_abnormal_hair_follicle1.60900397
34MP0003950_abnormal_plasma_membrane1.56946744
35MP0000462_abnormal_digestive_system1.56754049
36MP0005508_abnormal_skeleton_morphology1.56608695
37MP0003385_abnormal_body_wall1.49826222
38MP0009780_abnormal_chondrocyte_physiolo1.47453671
39MP0000647_abnormal_sebaceous_gland1.45316592
40MP0001348_abnormal_lacrimal_gland1.43246088
41MP0000733_abnormal_muscle_development1.41712788
42MP0000427_abnormal_hair_cycle1.37458919
43MP0009250_abnormal_appendicular_skeleto1.35210302
44MP0004381_abnormal_hair_follicle1.33926030
45MP0005023_abnormal_wound_healing1.32716828
46MP0002877_abnormal_melanocyte_morpholog1.29612586
47MP0005076_abnormal_cell_differentiation1.27824844
48MP0000678_abnormal_parathyroid_gland1.26909453
49MP0010368_abnormal_lymphatic_system1.24995709
50MP0003755_abnormal_palate_morphology1.23544236
51MP0000537_abnormal_urethra_morphology1.23360431
52MP0001299_abnormal_eye_distance/1.23190468
53MP0001340_abnormal_eyelid_morphology1.23079494
54MP0000013_abnormal_adipose_tissue1.19365486
55MP0002282_abnormal_trachea_morphology1.17161305
56MP0002932_abnormal_joint_morphology1.14759499
57MP0000428_abnormal_craniofacial_morphol1.13786815
58MP0000534_abnormal_ureter_morphology1.12423842
59* MP0009931_abnormal_skin_appearance1.11330927
60MP0008260_abnormal_autophagy1.11074806
61MP0003115_abnormal_respiratory_system1.10215995
62MP0000750_abnormal_muscle_regeneration1.09788066
63MP0003942_abnormal_urinary_system1.09195879
64MP0002249_abnormal_larynx_morphology1.08586942
65MP0000566_synostosis1.07748733
66* MP0002896_abnormal_bone_mineralization1.05525114
67MP0002108_abnormal_muscle_morphology1.03343078
68MP0003283_abnormal_digestive_organ1.02810594
69MP0000751_myopathy1.02669481
70MP0004947_skin_inflammation1.02448854
71MP0000858_altered_metastatic_potential1.01829111
72MP0009379_abnormal_foot_pigmentation1.00329244
73MP0000003_abnormal_adipose_tissue0.97560811
74MP0000049_abnormal_middle_ear0.97557701
75MP0002111_abnormal_tail_morphology0.95065960
76MP0002177_abnormal_outer_ear0.91695371
77MP0002233_abnormal_nose_morphology0.91488489
78MP0003091_abnormal_cell_migration0.90918267
79MP0004858_abnormal_nervous_system0.88531419
80MP0003045_fibrosis0.88095883
81MP0005197_abnormal_uvea_morphology0.87997796
82MP0009384_cardiac_valve_regurgitation0.87728638
83* MP0000432_abnormal_head_morphology0.87031920
84MP0001346_abnormal_lacrimal_gland0.86325878
85MP0002116_abnormal_craniofacial_bone0.84701713
86MP0001542_abnormal_bone_strength0.84621080
87MP0003935_abnormal_craniofacial_develop0.82928098
88* MP0001191_abnormal_skin_condition0.82782879
89MP0000163_abnormal_cartilage_morphology0.81492329
90MP0006138_congestive_heart_failure0.81257641
91* MP0002109_abnormal_limb_morphology0.80891299
92MP0003937_abnormal_limbs/digits/tail_de0.80590223
93MP0005360_urolithiasis0.80247731
94* MP0002115_abnormal_skeleton_extremities0.79300462
95MP0000627_abnormal_mammary_gland0.78619608
96MP0005451_abnormal_body_composition0.77981350
97MP0004233_abnormal_muscle_weight0.77936058
98MP0005248_abnormal_Harderian_gland0.77866817
99MP0002295_abnormal_pulmonary_circulatio0.76996959
100MP0005621_abnormal_cell_physiology0.75356779
101MP0002089_abnormal_postnatal_growth/wei0.74666533
102MP0000767_abnormal_smooth_muscle0.73878295
103MP0005390_skeleton_phenotype0.73838537
104MP0004782_abnormal_surfactant_physiolog0.73757563
105MP0003448_altered_tumor_morphology0.72969368
106MP0002697_abnormal_eye_size0.72718031
107* MP0000367_abnormal_coat/_hair0.71983004
108MP0003191_abnormal_cellular_cholesterol0.71813963
109MP0005409_darkened_coat_color0.71251183
110MP0009840_abnormal_foam_cell0.70202883
111MP0003315_abnormal_perineum_morphology0.70038579
112MP0005375_adipose_tissue_phenotype0.69602367
113MP0005220_abnormal_exocrine_pancreas0.68060051
114MP0004264_abnormal_extraembryonic_tissu0.67617977
115MP0004185_abnormal_adipocyte_glucose0.67056598
116MP0004134_abnormal_chest_morphology0.65948502
117MP0002113_abnormal_skeleton_development0.64495370
118MP0005164_abnormal_response_to0.62210737
119MP0003329_amyloid_beta_deposits0.62112558
120MP0005193_abnormal_anterior_eye0.61606080
121MP0000759_abnormal_skeletal_muscle0.61148638
122MP0002114_abnormal_axial_skeleton0.60205494
123MP0005595_abnormal_vascular_smooth0.59474080

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.82939323
2* Atrophic scars (HP:0001075)6.81798617
3* Milia (HP:0001056)6.01311876
4Protrusio acetabuli (HP:0003179)5.11611960
5Ankle contracture (HP:0006466)5.04554376
6Type 1 muscle fiber predominance (HP:0003803)4.90400745
7Follicular hyperkeratosis (HP:0007502)4.80858346
8* Fragile skin (HP:0001030)4.79766936
9Increased connective tissue (HP:0009025)4.47704067
10Peritonitis (HP:0002586)4.41684578
11Aortic dissection (HP:0002647)4.14958739
12Shallow orbits (HP:0000586)4.10392444
13Bladder diverticulum (HP:0000015)4.03999707
14Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.03094838
15Short 4th metacarpal (HP:0010044)4.03094838
16Slender build (HP:0001533)3.89954478
17Soft skin (HP:0000977)3.85121276
18Abnormality of nail color (HP:0100643)3.76372526
19Fragile nails (HP:0001808)3.75977828
20Alopecia of scalp (HP:0002293)3.59121549
21Down-sloping shoulders (HP:0200021)3.51291233
22Spinal rigidity (HP:0003306)3.47598615
23Abnormality of the parietal bone (HP:0002696)3.42449828
24Cerebral aneurysm (HP:0004944)3.34470245
25Neoplasm of the heart (HP:0100544)3.30620990
26Mildly elevated creatine phosphokinase (HP:0008180)3.29691364
27Mitral valve prolapse (HP:0001634)3.27116011
28Dilatation of the ascending aorta (HP:0005111)3.26193732
29Broad face (HP:0000283)3.24983290
30Plantar hyperkeratosis (HP:0007556)3.15954789
31Ulnar bowing (HP:0003031)3.14392747
32Onycholysis (HP:0001806)3.14200260
33Cervical subluxation (HP:0003308)3.14109740
34Increased variability in muscle fiber diameter (HP:0003557)3.11381608
35Hypotrichosis (HP:0001006)3.05268315
36Genu recurvatum (HP:0002816)3.03346950
37Pili torti (HP:0003777)3.00999212
38Abnormality of the 4th metacarpal (HP:0010012)2.92351519
39Neonatal short-limb short stature (HP:0008921)2.90673313
40Broad metatarsal (HP:0001783)2.83221629
41Bowel diverticulosis (HP:0005222)2.74328119
42Abnormality of skeletal muscle fiber size (HP:0012084)2.71620917
43Vascular tortuosity (HP:0004948)2.66340407
44Arterial tortuosity (HP:0005116)2.62707712
45Thick nail (HP:0001805)2.61668080
46Infantile muscular hypotonia (HP:0008947)2.60499081
47Deviation of the hallux (HP:0010051)2.57807449
48Aortic aneurysm (HP:0004942)2.54211687
49Right ventricular cardiomyopathy (HP:0011663)2.53689634
50Short nail (HP:0001799)2.52240274
51Hallux valgus (HP:0001822)2.51492145
52Abnormality of the peritoneum (HP:0002585)2.50523332
53Woolly hair (HP:0002224)2.50156682
54Absent eyelashes (HP:0000561)2.47766242
55Venous insufficiency (HP:0005293)2.46712982
56Elbow flexion contracture (HP:0002987)2.45255224
57Pterygium (HP:0001059)2.45228530
58Blue sclerae (HP:0000592)2.44415978
59Hyperextensible skin (HP:0000974)2.39887985
60Abnormality of dentin (HP:0010299)2.39273225
61Venous abnormality (HP:0002624)2.37101692
62Renovascular hypertension (HP:0100817)2.34204395
63Coronal craniosynostosis (HP:0004440)2.33154327
64Abnormality of the distal phalanx of the thumb (HP:0009617)2.30107940
65Wormian bones (HP:0002645)2.27954396
66Vertebral compression fractures (HP:0002953)2.27169464
67Achilles tendon contracture (HP:0001771)2.26794584
68Nonimmune hydrops fetalis (HP:0001790)2.26615831
69Morphological abnormality of the middle ear (HP:0008609)2.26450069
70Supernumerary ribs (HP:0005815)2.25896324
71Tibial bowing (HP:0002982)2.25537072
72Distal lower limb amyotrophy (HP:0008944)2.23797960
73Short phalanx of the thumb (HP:0009660)2.20044934
74Aortic regurgitation (HP:0001659)2.19986176
75* Abnormal blistering of the skin (HP:0008066)2.19562028
76Palmoplantar hyperkeratosis (HP:0000972)2.18278062
77Distal upper limb amyotrophy (HP:0007149)2.13821198
78Upper limb amyotrophy (HP:0009129)2.13821198
79Bowed forearm bones (HP:0003956)2.13771542
80Bowing of the arm (HP:0006488)2.13771542
81Turricephaly (HP:0000262)2.13641503
82Distal lower limb muscle weakness (HP:0009053)2.12957085
83Ectopia lentis (HP:0001083)2.10495298
84Thin bony cortex (HP:0002753)2.10313450
85Round ear (HP:0100830)2.06969650
86Mitral regurgitation (HP:0001653)2.04944263
87Osteolytic defects of the phalanges of the hand (HP:0009771)2.04887492
88Osteolytic defects of the hand bones (HP:0009699)2.04887492
89Hypoventilation (HP:0002791)2.03999667
90Sparse lateral eyebrow (HP:0005338)2.03202232
91* Hypoplasia of dental enamel (HP:0006297)2.02278520
92Abnormality of the Achilles tendon (HP:0005109)2.00924045
93Palmar hyperkeratosis (HP:0010765)2.00855226
94Joint laxity (HP:0001388)1.98972693
95Supernumerary bones of the axial skeleton (HP:0009144)1.97719231
96Vertebral arch anomaly (HP:0008438)1.96632348
97Renal duplication (HP:0000075)1.95870562
98Difficulty climbing stairs (HP:0003551)1.95338890
99* Nail dystrophy (HP:0008404)1.95228124
100Trismus (HP:0000211)1.95218800
101Muscle fiber splitting (HP:0003555)1.94844166
102Selective tooth agenesis (HP:0001592)1.94692179
103Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.94559336
104Lip pit (HP:0100267)1.94274027
105Sparse scalp hair (HP:0002209)1.93616797
106Hydroureter (HP:0000072)1.91043129
107Flat acetabular roof (HP:0003180)1.90946564
108Abnormal ossification of hand bones (HP:0005921)1.90193058
109Ridged nail (HP:0001807)1.89996705
110Hyperacusis (HP:0010780)1.89125088
111Abnormal hair laboratory examination (HP:0003328)1.87586831
112Generalized amyotrophy (HP:0003700)1.85616868
113Deformed sella turcica (HP:0002681)1.85594061
114Abnormality of the salivary glands (HP:0010286)1.85165837
115Bronchomalacia (HP:0002780)1.83325783
116Abnormal delivery (HP:0001787)1.82741613
117Neonatal death (HP:0003811)1.81893325
118Aplasia cutis congenita (HP:0001057)1.81586973
119Limb-girdle muscle weakness (HP:0003325)1.81156578
120Aplasia of the phalanges of the hand (HP:0009802)1.81153553
121Aplasia involving bones of the extremities (HP:0009825)1.81153553
122Aplasia involving bones of the upper limbs (HP:0009823)1.81153553
123Radial bowing (HP:0002986)1.80391574
124Biconcave vertebral bodies (HP:0004586)1.79022981
125Natal tooth (HP:0000695)1.77399976
126Advanced eruption of teeth (HP:0006288)1.77145274
127Wrist flexion contracture (HP:0001239)1.75328147
128* Thin skin (HP:0000963)1.74940797
129Flat cornea (HP:0007720)1.73467077
130Protruding ear (HP:0000411)1.73361429
131Neoplasm of the oral cavity (HP:0100649)1.71609549
132Spondylolisthesis (HP:0003302)1.70932231
133Aneurysm (HP:0002617)1.69470787
134Abnormality of the acetabulum (HP:0003170)1.67996257
135Abnormality of the distal phalanges of the toes (HP:0010182)1.65556728
136Oligodontia (HP:0000677)1.65309898
137Long palpebral fissure (HP:0000637)1.63885255
138Abnormality of the calcaneus (HP:0008364)1.63840304
139Obstructive sleep apnea (HP:0002870)1.63061265
140Lower limb amyotrophy (HP:0007210)1.61754002
141Hypoplastic labia majora (HP:0000059)1.60535031
142Sparse eyelashes (HP:0000653)1.60342369
143Disproportionate tall stature (HP:0001519)1.59940511

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.39088151
2EPHA23.58920590
3TTN3.32358809
4LATS13.25210858
5RIPK12.91995756
6ERN12.89725952
7SIK12.81134096
8PKN22.77889089
9EPHB22.76893650
10MAP3K102.66629236
11DDR22.62033059
12EEF2K2.57510247
13BMX2.47022517
14FER2.33145082
15MST1R2.31123003
16LATS22.15819004
17PTK62.11056745
18CDK121.99388527
19PAK21.93823679
20PDGFRA1.93603403
21MYLK1.88556611
22MAPKAPK31.87411886
23MAP3K31.86887645
24IRAK31.84010159
25PTK21.79170895
26MAP3K61.72909815
27SMG11.68274569
28FGFR11.66174438
29PRKCI1.65839503
30MET1.63738560
31ARAF1.56153578
32TRPM71.48263793
33EPHB11.45426302
34LRRK21.43856099
35TAOK11.33368393
36RPS6KB21.26198065
37PIK3CG1.25153321
38DMPK1.21639373
39LMTK21.10443603
40MTOR1.09490627
41FGFR41.08179291
42MAP2K21.08161780
43NME21.06215451
44DYRK1B1.05565658
45PAK41.05317353
46FLT30.97781996
47STK30.96244905
48MAP3K70.96107642
49TGFBR10.93361487
50RPS6KA40.93222350
51PRPF4B0.91252096
52ICK0.89336960
53PDGFRB0.89149676
54EPHA30.88990792
55PIK3CA0.86325017
56MAP3K20.85656772
57MAP3K90.84762932
58FGFR20.83628432
59PRKD20.83132544
60MAP3K130.81044865
61ILK0.78627313
62PAK30.73030012
63STK240.71580478
64MAP2K10.71292129
65PRKD10.70976341
66LIMK10.68497559
67TGFBR20.67738549
68MAP3K10.67333989
69CDK60.67324541
70MAPK150.66511451
71MAP3K110.66135574
72RET0.63723205
73ERBB40.59609393
74ERBB20.58588016
75RPS6KA20.55475822
76TESK10.55042753
77MARK20.54174495
78ABL20.53689852
79MAPK110.51288090
80ROCK10.51062563
81STK100.50892535
82BRAF0.50651436
83TNK20.49361869
84CAMK1G0.49166250
85MAPKAPK20.49110107
86NME10.48434190
87PTK2B0.48235785
88ROCK20.47493384
89PIM20.46814495
90PRKG20.46311947
91MAP2K30.46292259
92CAMK2G0.46272474
93NEK90.45777004
94MAP3K80.44400692
95MOS0.44385720
96SIK20.44220972
97RPS6KA10.43085089
98CHUK0.42622944
99KSR20.41878151
100MAPKAPK50.40595163
101STK38L0.40238890
102MAPK10.39519184
103INSR0.39283837
104PBK0.38094502
105CDC42BPA0.37598749
106NTRK10.37413783
107RAF10.37007785
108GSK3A0.36913891
109MAPK70.36836914
110BCKDK0.35287665
111SRC0.35024593
112PDPK10.34923312
113FGFR30.33152653
114CAMK1D0.31308079
115RPS6KC10.31024264
116RPS6KL10.31024264
117ALK0.30837575
118TYRO30.30107876
119STK380.30067557
120MELK0.28344350
121CDK70.27798414
122MAPK90.27415636
123CDK80.26217718
124CLK10.24418329
125PAK10.23955907
126MATK0.23666270
127RPS6KA60.23398967
128DAPK30.23119965
129AKT30.22969828
130HIPK20.22921768
131PRKCH0.22283833
132MAPK80.21954813

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.78425642
2Basal cell carcinoma_Homo sapiens_hsa052174.51116301
3* Protein digestion and absorption_Homo sapiens_hsa049743.94365937
4Hedgehog signaling pathway_Homo sapiens_hsa043403.82756130
5Focal adhesion_Homo sapiens_hsa045102.76688059
6Amoebiasis_Homo sapiens_hsa051462.59760234
7Proteoglycans in cancer_Homo sapiens_hsa052052.42908753
8Small cell lung cancer_Homo sapiens_hsa052222.39114461
9Hippo signaling pathway_Homo sapiens_hsa043902.31360375
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.11184139
11Bladder cancer_Homo sapiens_hsa052192.06634036
12Notch signaling pathway_Homo sapiens_hsa043302.06325161
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.97021549
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.76149564
15Adherens junction_Homo sapiens_hsa045201.72073040
16Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.68465996
17MicroRNAs in cancer_Homo sapiens_hsa052061.54218959
18Melanogenesis_Homo sapiens_hsa049161.49527023
19Pathways in cancer_Homo sapiens_hsa052001.40793160
20PI3K-Akt signaling pathway_Homo sapiens_hsa041511.39854496
21Other glycan degradation_Homo sapiens_hsa005111.39450121
22Fructose and mannose metabolism_Homo sapiens_hsa000511.38739135
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.38466126
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.37571457
25Dilated cardiomyopathy_Homo sapiens_hsa054141.37301353
26Wnt signaling pathway_Homo sapiens_hsa043101.35692831
27Chronic myeloid leukemia_Homo sapiens_hsa052201.30866694
28Axon guidance_Homo sapiens_hsa043601.28924203
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.28066307
30TGF-beta signaling pathway_Homo sapiens_hsa043501.27447007
31Toxoplasmosis_Homo sapiens_hsa051451.25693640
32Galactose metabolism_Homo sapiens_hsa000521.23293232
33Prion diseases_Homo sapiens_hsa050201.18114944
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16810875
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.13231950
36Tight junction_Homo sapiens_hsa045301.11299116
37Endometrial cancer_Homo sapiens_hsa052131.11119662
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.07652172
39VEGF signaling pathway_Homo sapiens_hsa043701.05716511
40Regulation of actin cytoskeleton_Homo sapiens_hsa048101.04734892
41Acute myeloid leukemia_Homo sapiens_hsa052211.02676456
42Pancreatic secretion_Homo sapiens_hsa049721.01444474
43Melanoma_Homo sapiens_hsa052181.01117168
44Prostate cancer_Homo sapiens_hsa052150.98713289
45Platelet activation_Homo sapiens_hsa046110.98544852
46HTLV-I infection_Homo sapiens_hsa051660.97519547
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.95530618
48p53 signaling pathway_Homo sapiens_hsa041150.92862467
49Pancreatic cancer_Homo sapiens_hsa052120.88793303
50Glioma_Homo sapiens_hsa052140.86941859
51Estrogen signaling pathway_Homo sapiens_hsa049150.86529245
52Central carbon metabolism in cancer_Homo sapiens_hsa052300.85530310
53Thyroid cancer_Homo sapiens_hsa052160.83626948
54Renal cell carcinoma_Homo sapiens_hsa052110.83355285
55Rap1 signaling pathway_Homo sapiens_hsa040150.82799521
56Colorectal cancer_Homo sapiens_hsa052100.79271655
57GnRH signaling pathway_Homo sapiens_hsa049120.78228356
58Non-small cell lung cancer_Homo sapiens_hsa052230.76915094
59ErbB signaling pathway_Homo sapiens_hsa040120.76904397
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75022310
61mTOR signaling pathway_Homo sapiens_hsa041500.72722948
62TNF signaling pathway_Homo sapiens_hsa046680.72401696
63Vitamin B6 metabolism_Homo sapiens_hsa007500.70178752
64Pentose phosphate pathway_Homo sapiens_hsa000300.68008960
65Insulin resistance_Homo sapiens_hsa049310.67494282
66Viral myocarditis_Homo sapiens_hsa054160.66527508
67N-Glycan biosynthesis_Homo sapiens_hsa005100.66302517
68Thyroid hormone synthesis_Homo sapiens_hsa049180.65980671
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65870045
70Inositol phosphate metabolism_Homo sapiens_hsa005620.65451983
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64520475
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64315614
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64233494
74Choline metabolism in cancer_Homo sapiens_hsa052310.63604730
75Apoptosis_Homo sapiens_hsa042100.62443392
76Dorso-ventral axis formation_Homo sapiens_hsa043200.60589616
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59145964
78Malaria_Homo sapiens_hsa051440.57105439
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56610629
80Shigellosis_Homo sapiens_hsa051310.55732074
81Glucagon signaling pathway_Homo sapiens_hsa049220.55626204
82Prolactin signaling pathway_Homo sapiens_hsa049170.54287288
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.53654307
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53490121
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53131572
86Sphingolipid metabolism_Homo sapiens_hsa006000.51845482
87Hepatitis C_Homo sapiens_hsa051600.51161120
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50598921
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50254555
90Arginine biosynthesis_Homo sapiens_hsa002200.49998959
91Vibrio cholerae infection_Homo sapiens_hsa051100.46612060
92Hepatitis B_Homo sapiens_hsa051610.46531830
93HIF-1 signaling pathway_Homo sapiens_hsa040660.46488170
94Ras signaling pathway_Homo sapiens_hsa040140.46126816
95MAPK signaling pathway_Homo sapiens_hsa040100.46027229
96Lysosome_Homo sapiens_hsa041420.45413787
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.44541661
98Biosynthesis of amino acids_Homo sapiens_hsa012300.43687767
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43542180
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42687547
101Endocytosis_Homo sapiens_hsa041440.42111880
102FoxO signaling pathway_Homo sapiens_hsa040680.42068253
103Gap junction_Homo sapiens_hsa045400.41894981
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41365171
105Viral carcinogenesis_Homo sapiens_hsa052030.39462945
106Fat digestion and absorption_Homo sapiens_hsa049750.38745677
107Oxytocin signaling pathway_Homo sapiens_hsa049210.38522762
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.38427404
109Lysine degradation_Homo sapiens_hsa003100.38402078
110Insulin signaling pathway_Homo sapiens_hsa049100.36859516
111AMPK signaling pathway_Homo sapiens_hsa041520.36258363
112Salmonella infection_Homo sapiens_hsa051320.36170307
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36101785
114Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.35751252
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34168923
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33304593
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.32136330
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31362714
119Gastric acid secretion_Homo sapiens_hsa049710.29013260
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.27620670
121Aldosterone synthesis and secretion_Homo sapiens_hsa049250.26449181
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.25704010

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