COL8A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the alpha 2 chain of type VIII collagen. This protein is a major component of the basement membrane of the corneal endothelium and forms homo- or heterotrimers with alpha 1 (VIII) type collagens. Defects in this gene are associated with Fuchs endothelial corneal dystrophy and posterior polymorphous corneal dystrophy type 2. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vitamin A metabolic process (GO:0006776)8.93976527
2protein heterotrimerization (GO:0070208)8.02126014
3positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr7.27841173
4regulation of branching involved in salivary gland morphogenesis (GO:0060693)7.19687083
5bone trabecula formation (GO:0060346)7.11449285
6collagen fibril organization (GO:0030199)6.78331015
7embryonic camera-type eye development (GO:0031076)6.57335542
8lateral sprouting from an epithelium (GO:0060601)6.55850042
9regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 6.19981460
10otic vesicle formation (GO:0030916)6.14853860
11cell migration involved in heart development (GO:0060973)6.12341701
12radial glial cell differentiation (GO:0060019)6.07200983
13cornea development in camera-type eye (GO:0061303)6.02203461
14skeletal muscle adaptation (GO:0043501)5.64834218
15negative regulation of stress fiber assembly (GO:0051497)5.56358802
16keratan sulfate catabolic process (GO:0042340)5.51365611
17skin morphogenesis (GO:0043589)5.22312607
18sequestering of extracellular ligand from receptor (GO:0035581)5.20352701
19protein localization to cell surface (GO:0034394)5.02493403
20muscle cell fate commitment (GO:0042693)4.82271357
21lung epithelium development (GO:0060428)4.76086738
22* collagen metabolic process (GO:0032963)4.67744640
23* collagen catabolic process (GO:0030574)4.65062930
24organ growth (GO:0035265)4.61895313
25negative regulation of Rho protein signal transduction (GO:0035024)4.56364917
26venous blood vessel morphogenesis (GO:0048845)4.55844802
27limb bud formation (GO:0060174)4.52573922
28chondrocyte proliferation (GO:0035988)4.47296439
29* multicellular organismal macromolecule metabolic process (GO:0044259)4.39812245
30planar cell polarity pathway involved in neural tube closure (GO:0090179)4.36141291
31keratan sulfate biosynthetic process (GO:0018146)4.31890863
32* multicellular organismal catabolic process (GO:0044243)4.26259092
33peripheral nervous system axon ensheathment (GO:0032292)4.25131943
34myelination in peripheral nervous system (GO:0022011)4.25131943
35neuronal ion channel clustering (GO:0045161)4.22747142
36chondrocyte development (GO:0002063)4.17676983
37keratan sulfate metabolic process (GO:0042339)4.16081436
38* multicellular organismal metabolic process (GO:0044236)4.12477946
39retinal metabolic process (GO:0042574)4.05154472
40endodermal cell differentiation (GO:0035987)4.04034657
41axon extension involved in axon guidance (GO:0048846)4.03592730
42neuron projection extension involved in neuron projection guidance (GO:1902284)4.03592730
43positive regulation of cell junction assembly (GO:1901890)4.03220107
44positive regulation of focal adhesion assembly (GO:0051894)4.03220107
45regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.02187683
46extracellular fibril organization (GO:0043206)4.01201988
47negative regulation of chondrocyte differentiation (GO:0032331)3.99152415
48negative regulation of actin filament bundle assembly (GO:0032232)3.98110913
49positive regulation of adherens junction organization (GO:1903393)3.98036070
50induction of positive chemotaxis (GO:0050930)3.91673098
51negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.88595229
52outer ear morphogenesis (GO:0042473)3.80408965
53regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.79543825
54embryonic digestive tract morphogenesis (GO:0048557)3.79493892
55genitalia morphogenesis (GO:0035112)3.78962665
56bicarbonate transport (GO:0015701)3.76411959
57* extracellular matrix disassembly (GO:0022617)3.75980558
58middle ear morphogenesis (GO:0042474)3.75194456
59positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)3.73933719
60cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.73274858
61branch elongation of an epithelium (GO:0060602)3.70165017
62regulation of mitochondrial depolarization (GO:0051900)3.68917547
63metanephric mesenchyme development (GO:0072075)3.65507516
64embryonic cranial skeleton morphogenesis (GO:0048701)3.62025440
65white fat cell differentiation (GO:0050872)3.55153065
66mesenchymal-epithelial cell signaling (GO:0060638)3.54629160
67mesonephros development (GO:0001823)3.54130479
68dermatan sulfate biosynthetic process (GO:0030208)3.53497201
69smooth muscle cell differentiation (GO:0051145)3.48788804
70kidney mesenchyme development (GO:0072074)3.46061322
71keratinocyte proliferation (GO:0043616)3.44851523
72craniofacial suture morphogenesis (GO:0097094)3.41586189
73negative regulation of cartilage development (GO:0061037)3.40165020
74fibril organization (GO:0097435)3.36640531
75cellular response to vitamin D (GO:0071305)3.35003383
76positive regulation of mesenchymal cell proliferation (GO:0002053)3.34212649
77extracellular matrix assembly (GO:0085029)3.31713822
78G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.31096215
79tooth mineralization (GO:0034505)3.30455845
80syncytium formation by plasma membrane fusion (GO:0000768)3.29421951
81negative regulation of embryonic development (GO:0045992)3.28561177
82cardiac muscle cell proliferation (GO:0060038)3.28094128
83face morphogenesis (GO:0060325)3.27461904
84regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.26940546
85cellular response to vitamin (GO:0071295)3.25622628
86extracellular regulation of signal transduction (GO:1900115)3.23620415
87extracellular negative regulation of signal transduction (GO:1900116)3.23620415
88axis elongation (GO:0003401)3.23388945
89Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.20312600
90bone morphogenesis (GO:0060349)3.18477734
91regulation of mesenchymal cell proliferation (GO:0010464)3.18338866
92mesenchymal cell proliferation (GO:0010463)3.17809295
93dermatan sulfate metabolic process (GO:0030205)3.17420679
94phagocytosis, recognition (GO:0006910)3.16696312
95regulation of heart morphogenesis (GO:2000826)3.15295715
96positive regulation of bone remodeling (GO:0046852)3.14262942
97positive regulation of bone resorption (GO:0045780)3.14262942
98non-canonical Wnt signaling pathway (GO:0035567)3.13976230
99positive regulation of epithelial to mesenchymal transition (GO:0010718)3.13020538
100kidney morphogenesis (GO:0060993)3.12594970
101striated muscle cell proliferation (GO:0014855)3.11207447
102* extracellular matrix organization (GO:0030198)3.10738913
103* extracellular structure organization (GO:0043062)3.09404871
104glomerular filtration (GO:0003094)3.04716231
105regulation of establishment of planar polarity (GO:0090175)3.04681216
106lung secretory cell differentiation (GO:0061140)3.03534572
107insulin-like growth factor receptor signaling pathway (GO:0048009)3.02535499
108cell adhesion mediated by integrin (GO:0033627)3.01260011
109myoblast fusion (GO:0007520)3.00959080
110positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)2.95244435
111substrate-dependent cell migration (GO:0006929)2.94882480
112replacement ossification (GO:0036075)2.92163063
113endochondral ossification (GO:0001958)2.92163063
114glomerular basement membrane development (GO:0032836)2.92062090
115dorsal/ventral axis specification (GO:0009950)2.89893827
116positive regulation of smoothened signaling pathway (GO:0045880)2.89243586
117regulation of non-canonical Wnt signaling pathway (GO:2000050)2.88645182
118convergent extension (GO:0060026)2.86461866
119adhesion of symbiont to host (GO:0044406)2.84982967
120hippo signaling (GO:0035329)2.84627382
121glycosaminoglycan catabolic process (GO:0006027)2.84293525
122lung-associated mesenchyme development (GO:0060484)2.83809585
123negative regulation of catenin import into nucleus (GO:0035414)2.82079232
124trabecula formation (GO:0060343)2.81839809
125melanin biosynthetic process (GO:0042438)2.81295463
126prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.80048272
127cranial suture morphogenesis (GO:0060363)2.79123109
128mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.78483064
129organ induction (GO:0001759)2.78092664
130endocardial cushion morphogenesis (GO:0003203)2.77935148
131ossification (GO:0001503)2.76395710
132endothelial cell chemotaxis (GO:0035767)2.75873754
133regulation of chondrocyte differentiation (GO:0032330)2.75305618
134regulation of extracellular matrix disassembly (GO:0010715)2.72279217
135regulation of cartilage development (GO:0061035)2.72241062
136* camera-type eye morphogenesis (GO:0048593)2.70664600
137positive regulation of cartilage development (GO:0061036)2.70259821
138morphogenesis of an epithelial fold (GO:0060571)2.69722122
139renal filtration (GO:0097205)2.69562119
140cell proliferation involved in metanephros development (GO:0072203)2.69268277
141positive regulation of stem cell differentiation (GO:2000738)2.68951648
142aminoglycan catabolic process (GO:0006026)2.68878910
143cellular response to amino acid stimulus (GO:0071230)2.68001490
144cartilage morphogenesis (GO:0060536)2.67821504
145organ formation (GO:0048645)2.67167400
146adhesion of symbiont to host cell (GO:0044650)2.65484423
147virion attachment to host cell (GO:0019062)2.65484423
148epithelial cell-cell adhesion (GO:0090136)2.64601333
149ventricular cardiac muscle cell development (GO:0055015)2.64214775
150striated muscle hypertrophy (GO:0014897)2.64207002
151mesenchyme morphogenesis (GO:0072132)2.63855981
152muscle cell proliferation (GO:0033002)2.63759955
153sulfur compound catabolic process (GO:0044273)2.63590465
154peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.63308017
155cochlea morphogenesis (GO:0090103)2.63177578
156peptidyl-proline hydroxylation (GO:0019511)2.63134958
157protein trimerization (GO:0070206)2.62747223
158regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.62018606
159retinol metabolic process (GO:0042572)2.61823529
160smooth muscle tissue development (GO:0048745)2.61626141
161blood vessel maturation (GO:0001955)2.60952200
162negative regulation of cell-matrix adhesion (GO:0001953)2.60236733
163branching involved in salivary gland morphogenesis (GO:0060445)2.59667288
164regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.58894114
165mesenchymal cell differentiation (GO:0048762)2.56408993
166glycosaminoglycan biosynthetic process (GO:0006024)2.53888444
167regulation of cholesterol homeostasis (GO:2000188)2.53875805
168syncytium formation (GO:0006949)2.53814426
169aminoglycan biosynthetic process (GO:0006023)2.51003672
170hair follicle morphogenesis (GO:0031069)2.50904532

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.31661421
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.05263755
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.08610239
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.08417051
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.05119150
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.67480825
7WT1_19549856_ChIP-ChIP_CCG9911_Human2.66441600
8* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.41047871
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.36881185
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.36881185
11* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.31932900
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.27982168
13CJUN_26792858_Chip-Seq_BT549_Human2.24481302
14CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.17029856
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.12425477
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11434666
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.10693652
18TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.04522552
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.01029645
20PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.99142272
21CLOCK_20551151_ChIP-Seq_293T_Human1.99027435
22EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.97765790
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.96815387
24RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.96799651
25* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.95229482
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.93462237
27EP300_21415370_ChIP-Seq_HL-1_Mouse1.91841345
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.90672039
29LXR_22292898_ChIP-Seq_THP-1_Human1.86404657
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.85858559
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.85162996
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.82545706
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79378796
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77416914
35* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.75203655
36TP53_20018659_ChIP-ChIP_R1E_Mouse1.66399378
37* RNF2_27304074_Chip-Seq_ESCs_Mouse1.64751959
38TP53_18474530_ChIP-ChIP_U2OS_Human1.56567305
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.56201401
40CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.54723287
41BRD4_25478319_ChIP-Seq_HGPS_Human1.53105091
42* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.51046875
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.50926281
44AR_21572438_ChIP-Seq_LNCaP_Human1.50571356
45* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.49750257
46NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.46407679
47NRF2_20460467_ChIP-Seq_MEFs_Mouse1.46407679
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.42839768
49TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.41718456
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38107447
51* EZH2_27294783_Chip-Seq_ESCs_Mouse1.37378560
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34843043
53SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.34349725
54EGR1_19032775_ChIP-ChIP_M12_Human1.31698745
55TP53_16413492_ChIP-PET_HCT116_Human1.31511913
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.30874037
57* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30581620
58* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.28196907
59* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.27444391
60DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27413065
61ESR1_21235772_ChIP-Seq_MCF-7_Human1.26825298
62* RING1B_27294783_Chip-Seq_NPCs_Mouse1.25688582
63ISL1_27105846_Chip-Seq_CPCs_Mouse1.24060711
64CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.23530675
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.22484576
66PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21204634
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20986872
68SMC1_22415368_ChIP-Seq_MEFs_Mouse1.20934300
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19036756
70* SA1_27219007_Chip-Seq_ERYTHROID_Human1.18338246
71DROSHA_22980978_ChIP-Seq_HELA_Human1.17515889
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17377479
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.16597175
74PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.16193222
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15217340
76* STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.10724352
77SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09901672
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.09427843
79MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08978789
80RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08976879
81WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08823798
82NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07808098
83ESR2_21235772_ChIP-Seq_MCF-7_Human1.07104278
84AHR_22903824_ChIP-Seq_MCF-7_Human1.05992013
85Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04401447
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.03954780
87ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03734675
88TCF4_18268006_ChIP-ChIP_LS174T_Human1.03669272
89P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03437992
90RACK7_27058665_Chip-Seq_MCF-7_Human1.02831284
91JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02383256
92JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02093896
93P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01430490
94ERG_21242973_ChIP-ChIP_JURKAT_Human0.99830583
95POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98592594
96SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97871204
97KDM2B_26808549_Chip-Seq_DND41_Human0.97664723
98TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97590762
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97458739
100CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97218482
101GATA1_19941827_ChIP-Seq_MEL_Mouse0.96974792
102SA1_22415368_ChIP-Seq_MEFs_Mouse0.96762592
103* TP53_23651856_ChIP-Seq_MEFs_Mouse0.96369898
104SMC3_22415368_ChIP-Seq_MEFs_Mouse0.96249745
105NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96156653
106SOX2_20726797_ChIP-Seq_SW620_Human0.95164181
107KDM2B_26808549_Chip-Seq_K562_Human0.93543068
108* CTCF_27219007_Chip-Seq_Bcells_Human0.93393196
109DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92981833
110HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92872854
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92048355
112CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91832802
113KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91676269
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90986508
115ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90972773
116TP53_22127205_ChIP-Seq_IMR90_Human0.90919442
117TBX20_22328084_ChIP-Seq_HEART_Mouse0.90507064
118TBX20_22080862_ChIP-Seq_HEART_Mouse0.90507064
119NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.90252014
120RXR_22108803_ChIP-Seq_LS180_Human0.89807990
121POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89470682
122UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87992028
123SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87828316
124CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87360199
125FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.87161589
126NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86976904
127SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.86956503
128SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.86540630
129EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85737574
130IRF8_27001747_Chip-Seq_BMDM_Mouse0.85695223
131NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85473952
132KDM2B_26808549_Chip-Seq_JURKAT_Human0.85300312
133VDR_24787735_ChIP-Seq_THP-1_Human0.85022681
134FOXO3_23340844_ChIP-Seq_DLD1_Human0.84562988
135UBF1/2_26484160_Chip-Seq_HMECs_Human0.83861370
136SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83850196

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.43520558
2MP0005377_hearing/vestibular/ear_phenot6.94012776
3MP0003878_abnormal_ear_physiology6.94012776
4MP0005503_abnormal_tendon_morphology6.27144653
5MP0005275_abnormal_skin_tensile5.36406029
6MP0005257_abnormal_intraocular_pressure4.35874997
7MP0003011_delayed_dark_adaptation4.30344848
8MP0002102_abnormal_ear_morphology4.13871990
9MP0003279_aneurysm3.26339661
10MP0006054_spinal_hemorrhage3.20684653
11MP0003705_abnormal_hypodermis_morpholog3.18872360
12MP0001958_emphysema3.15081176
13MP0004885_abnormal_endolymph2.53661169
14MP0009384_cardiac_valve_regurgitation2.50971201
15MP0005508_abnormal_skeleton_morphology2.48583329
16MP0001661_extended_life_span2.48223615
17MP0001542_abnormal_bone_strength2.47208563
18MP0004272_abnormal_basement_membrane2.35051232
19MP0009250_abnormal_appendicular_skeleto2.31950180
20MP0002132_abnormal_respiratory_system2.25019798
21MP0010030_abnormal_orbit_morphology2.08841927
22MP0005623_abnormal_meninges_morphology2.00886891
23MP0002108_abnormal_muscle_morphology2.00356859
24MP0003385_abnormal_body_wall1.95772903
25MP0002896_abnormal_bone_mineralization1.91464194
26MP0002060_abnormal_skin_morphology1.83585445
27MP0005171_absent_coat_pigmentation1.82136064
28MP0002282_abnormal_trachea_morphology1.74629135
29MP0004742_abnormal_vestibular_system1.66244709
30MP0004134_abnormal_chest_morphology1.64761340
31MP0002249_abnormal_larynx_morphology1.63427721
32MP0000566_synostosis1.52684899
33MP0000428_abnormal_craniofacial_morphol1.52635082
34MP0002115_abnormal_skeleton_extremities1.49666899
35MP0000579_abnormal_nail_morphology1.47586943
36MP0000163_abnormal_cartilage_morphology1.45197529
37MP0000049_abnormal_middle_ear1.44605835
38MP0002295_abnormal_pulmonary_circulatio1.43090482
39MP0005058_abnormal_lysosome_morphology1.40442842
40MP0002233_abnormal_nose_morphology1.37981607
41MP0003942_abnormal_urinary_system1.36227180
42MP0000372_irregular_coat_pigmentation1.35495462
43MP0005390_skeleton_phenotype1.34142469
44MP0002932_abnormal_joint_morphology1.32655132
45MP0003122_maternal_imprinting1.32171031
46MP0003136_yellow_coat_color1.30120863
47MP0000762_abnormal_tongue_morphology1.26815993
48MP0001756_abnormal_urination1.24767263
49MP0002998_abnormal_bone_remodeling1.21818432
50MP0003755_abnormal_palate_morphology1.21131598
51MP0001299_abnormal_eye_distance/1.20637456
52MP0003937_abnormal_limbs/digits/tail_de1.20126982
53MP0003115_abnormal_respiratory_system1.16923887
54MP0002109_abnormal_limb_morphology1.16690527
55MP0003566_abnormal_cell_adhesion1.15883172
56MP0002113_abnormal_skeleton_development1.15631172
57MP0000534_abnormal_ureter_morphology1.14957676
58MP0002116_abnormal_craniofacial_bone1.13905292
59MP0002277_abnormal_respiratory_mucosa1.13646639
60MP0001243_abnormal_dermal_layer1.12265034
61MP0003283_abnormal_digestive_organ1.11841839
62MP0000013_abnormal_adipose_tissue1.11695990
63MP0009053_abnormal_anal_canal1.10452135
64MP0009840_abnormal_foam_cell1.08459966
65MP0003935_abnormal_craniofacial_develop1.03403848
66MP0002909_abnormal_adrenal_gland1.02690537
67MP0005023_abnormal_wound_healing1.02333768
68MP0000767_abnormal_smooth_muscle1.01717737
69MP0000432_abnormal_head_morphology1.00898648
70MP0000537_abnormal_urethra_morphology0.99204800
71MP0003941_abnormal_skin_development0.98994237
72MP0000604_amyloidosis0.96199944
73MP0000733_abnormal_muscle_development0.94514039
74MP0002089_abnormal_postnatal_growth/wei0.92637302
75MP0003329_amyloid_beta_deposits0.92290380
76MP0002177_abnormal_outer_ear0.91150168
77MP0001270_distended_abdomen0.90337209
78MP0003795_abnormal_bone_structure0.86903758
79MP0000462_abnormal_digestive_system0.84377616
80MP0002933_joint_inflammation0.84360251
81MP0003191_abnormal_cellular_cholesterol0.82649006
82MP0003123_paternal_imprinting0.80956216
83MP0010368_abnormal_lymphatic_system0.78786907
84MP0002938_white_spotting0.78652131
85MP0003300_gastrointestinal_ulcer0.76987943
86MP0000026_abnormal_inner_ear0.76812933
87MP0000751_myopathy0.76260595
88MP0001177_atelectasis0.74822115
89MP0002111_abnormal_tail_morphology0.74693610
90MP0002114_abnormal_axial_skeleton0.74689386
91MP0005197_abnormal_uvea_morphology0.73499434
92MP0002133_abnormal_respiratory_system0.72070815
93MP0005388_respiratory_system_phenotype0.72070815
94MP0003938_abnormal_ear_development0.71196222
95MP0000516_abnormal_urinary_system0.69618417
96MP0005367_renal/urinary_system_phenotyp0.69618417
97MP0001879_abnormal_lymphatic_vessel0.69376021
98MP0001346_abnormal_lacrimal_gland0.68970141
99MP0002090_abnormal_vision0.68819420
100MP0003091_abnormal_cell_migration0.68684077
101MP0001533_abnormal_skeleton_physiology0.67848154
102* MP0002092_abnormal_eye_morphology0.67133850
103MP0001502_abnormal_circadian_rhythm0.66727897
104MP0009278_abnormal_bone_marrow0.65106335
105MP0009780_abnormal_chondrocyte_physiolo0.65066350
106MP0006072_abnormal_retinal_apoptosis0.64826215
107MP0000613_abnormal_salivary_gland0.64023260
108MP0004019_abnormal_vitamin_homeostasis0.63685368
109MP0002128_abnormal_blood_circulation0.61983300
110MP0003879_abnormal_hair_cell0.61648435
111MP0001324_abnormal_eye_pigmentation0.61270388
112MP0001963_abnormal_hearing_physiology0.60123190
113* MP0005193_abnormal_anterior_eye0.60078294
114MP0001348_abnormal_lacrimal_gland0.60036032
115MP0004858_abnormal_nervous_system0.59075067
116MP0001849_ear_inflammation0.58351307
117MP0002136_abnormal_kidney_physiology0.57672540
118MP0002697_abnormal_eye_size0.57534832
119MP0001175_abnormal_lung_morphology0.56896769
120MP0001614_abnormal_blood_vessel0.55985242
121MP0001340_abnormal_eyelid_morphology0.55665566
122MP0004185_abnormal_adipocyte_glucose0.54986840
123MP0002168_other_aberrant_phenotype0.53259601
124MP0005076_abnormal_cell_differentiation0.52383630
125MP0003453_abnormal_keratinocyte_physiol0.51963879
126MP0005248_abnormal_Harderian_gland0.51940759
127MP0002135_abnormal_kidney_morphology0.51494186
128MP0002877_abnormal_melanocyte_morpholog0.51396535
129MP0003172_abnormal_lysosome_physiology0.51271576
130MP0005408_hypopigmentation0.51159263
131MP0000343_altered_response_to0.47141547
132MP0005164_abnormal_response_to0.45941813
133MP0003448_altered_tumor_morphology0.45642165
134MP0009643_abnormal_urine_homeostasis0.43439814
135MP0002009_preneoplasia0.41192363
136MP0006082_CNS_inflammation0.40865454
137MP0002148_abnormal_hypersensitivity_rea0.40641687
138MP0005595_abnormal_vascular_smooth0.39253929
139MP0000569_abnormal_digit_pigmentation0.37322767
140MP0000470_abnormal_stomach_morphology0.36889307
141MP0000230_abnormal_systemic_arterial0.36417651
142MP0000003_abnormal_adipose_tissue0.34600595

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.32268752
2Premature rupture of membranes (HP:0001788)7.63774392
3Glomerulonephritis (HP:0000099)7.49026578
4Nephritis (HP:0000123)5.85542514
5Aplasia involving bones of the upper limbs (HP:0009823)5.46177221
6Aplasia of the phalanges of the hand (HP:0009802)5.46177221
7Aplasia involving bones of the extremities (HP:0009825)5.46177221
8Partial duplication of the phalanx of hand (HP:0009999)5.42467742
9Abnormality of dentin (HP:0010299)5.21833720
10Neonatal short-limb short stature (HP:0008921)4.94849817
11Shallow orbits (HP:0000586)4.79273195
12Aortic dissection (HP:0002647)4.75144114
13Atrophic scars (HP:0001075)4.69807856
14Partial duplication of thumb phalanx (HP:0009944)4.69487596
15Soft skin (HP:0000977)4.61509826
16Bladder diverticulum (HP:0000015)4.49455212
17Broad metatarsal (HP:0001783)4.39480467
18Peritonitis (HP:0002586)4.28438907
19Ankle contracture (HP:0006466)4.23246047
20Biconcave vertebral bodies (HP:0004586)4.17650193
21Corneal erosion (HP:0200020)3.97268292
22Abnormality of incisor morphology (HP:0011063)3.95834616
23Recurrent corneal erosions (HP:0000495)3.91117584
24Fragile skin (HP:0001030)3.67753728
25Wormian bones (HP:0002645)3.62832372
26Follicular hyperkeratosis (HP:0007502)3.57740691
27Turricephaly (HP:0000262)3.55201810
28Alacrima (HP:0000522)3.50060386
29Genu recurvatum (HP:0002816)3.49252132
30Mitral valve prolapse (HP:0001634)3.40414931
31Mixed hearing impairment (HP:0000410)3.39951847
32Blue sclerae (HP:0000592)3.38576466
33Type 1 muscle fiber predominance (HP:0003803)3.37078983
34Hypoplasia of the iris (HP:0007676)3.36096937
35Conical tooth (HP:0000698)3.28755258
36Dilatation of the ascending aorta (HP:0005111)3.28002266
37Aplasia of the musculature (HP:0100854)3.16031536
38Cerebral aneurysm (HP:0004944)3.14482656
39Bowel diverticulosis (HP:0005222)3.12406997
40Breech presentation (HP:0001623)3.04360974
41Decreased electroretinogram (ERG) amplitude (HP:0000654)3.00946988
42Aortic aneurysm (HP:0004942)2.97116022
43Mild short stature (HP:0003502)2.95953401
44Broad hallux (HP:0010055)2.92011824
45Decreased lacrimation (HP:0000633)2.88499206
46Congenital glaucoma (HP:0001087)2.86060038
47Morphological abnormality of the middle ear (HP:0008609)2.86048142
48Abnormal delivery (HP:0001787)2.85751880
49Hyperextensible skin (HP:0000974)2.82104758
50Spinal rigidity (HP:0003306)2.76921625
51Xerostomia (HP:0000217)2.74828221
52Femoral bowing (HP:0002980)2.71805777
53Nasolacrimal duct obstruction (HP:0000579)2.71239689
54Deviation of the hallux (HP:0010051)2.70872486
55Wide anterior fontanel (HP:0000260)2.69383819
56Nonprogressive disorder (HP:0003680)2.69323299
57Vertebral compression fractures (HP:0002953)2.67213913
58Infantile muscular hypotonia (HP:0008947)2.62770855
59Vascular tortuosity (HP:0004948)2.62430328
60Tibial bowing (HP:0002982)2.62319763
61Slender build (HP:0001533)2.61872379
62Abnormality of glycolipid metabolism (HP:0010969)2.61464076
63Abnormality of liposaccharide metabolism (HP:0010968)2.61464076
64Abnormality of glycosphingolipid metabolism (HP:0004343)2.61464076
65Hallux valgus (HP:0001822)2.60947870
66Spondylolisthesis (HP:0003302)2.59660031
67Broad toe (HP:0001837)2.54210542
68Concave nail (HP:0001598)2.53507723
69Hematuria (HP:0000790)2.53102297
70Broad ribs (HP:0000885)2.52110892
71Flat cornea (HP:0007720)2.51893586
72Abnormality of molar (HP:0011077)2.50536419
73Abnormality of molar morphology (HP:0011070)2.50536419
74Joint laxity (HP:0001388)2.50516704
75Osteoarthritis (HP:0002758)2.50245909
76Asymmetry of the thorax (HP:0001555)2.49279842
77Keratoconus (HP:0000563)2.49128067
78Increased corneal curvature (HP:0100692)2.49128067
79Exostoses (HP:0100777)2.48884569
80* Corneal dystrophy (HP:0001131)2.48003334
81Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.46076112
82Abnormality of the nasolacrimal system (HP:0000614)2.43613074
83Abnormality of the radial head (HP:0003995)2.40957249
84Bell-shaped thorax (HP:0001591)2.40520481
85Cervical subluxation (HP:0003308)2.37991868
86Stage 5 chronic kidney disease (HP:0003774)2.37294103
87Mesomelia (HP:0003027)2.35506009
88Arterial tortuosity (HP:0005116)2.31452641
89Abnormality of the dental root (HP:0006486)2.29798758
90Taurodontia (HP:0000679)2.29798758
91Abnormality of permanent molar morphology (HP:0011071)2.29798758
92Mitral regurgitation (HP:0001653)2.29756860
93Nonimmune hydrops fetalis (HP:0001790)2.27306012
94Ectopia lentis (HP:0001083)2.25215407
95Abnormality of the salivary glands (HP:0010286)2.23332417
96Ridged nail (HP:0001807)2.23162001
97Overgrowth (HP:0001548)2.21944213
98Osteolytic defects of the phalanges of the hand (HP:0009771)2.19548079
99Osteolytic defects of the hand bones (HP:0009699)2.19548079
100Abnormality of the dental pulp (HP:0006479)2.18871530
101Ulnar bowing (HP:0003031)2.17723667
102Increased variability in muscle fiber diameter (HP:0003557)2.17542594
103Wrist flexion contracture (HP:0001239)2.15459644
104Abnormality of the acetabulum (HP:0003170)2.13935870
105Abnormality of the lacrimal duct (HP:0011481)2.13427435
106Abnormality of the parietal bone (HP:0002696)2.13417861
107Broad long bones (HP:0005622)2.12822542
108Elbow flexion contracture (HP:0002987)2.11568089
109Long toe (HP:0010511)2.10909881
110Duplication of thumb phalanx (HP:0009942)2.10423752
111Mildly elevated creatine phosphokinase (HP:0008180)2.10179365
112Pulmonary artery stenosis (HP:0004415)2.08048988
113Coronal craniosynostosis (HP:0004440)2.08018217
114Aortic regurgitation (HP:0001659)2.07777596
115Absent frontal sinuses (HP:0002688)2.07068210
116Decreased skull ossification (HP:0004331)2.06864733
117Heterochromia iridis (HP:0001100)2.02786270
118Increased connective tissue (HP:0009025)2.02598821
119Narrow nasal bridge (HP:0000446)2.00595053
120Hypopigmentation of the fundus (HP:0007894)2.00359486
121Abnormality of the peritoneum (HP:0002585)1.99468715
122Anterior segment dysgenesis (HP:0007700)1.99207733
123Subacute progressive viral hepatitis (HP:0006572)1.97596078
124Systemic lupus erythematosus (HP:0002725)1.96843897
125Renal duplication (HP:0000075)1.96256285
126Abnormality of the musculature of the hand (HP:0001421)1.95977987
127Absent phalangeal crease (HP:0006109)1.95658547
128Inguinal hernia (HP:0000023)1.93191311
129Thin bony cortex (HP:0002753)1.91408860
130Round ear (HP:0100830)1.90701891
131Polar cataract (HP:0010696)1.90684284
132Venous insufficiency (HP:0005293)1.89235247
133Renovascular hypertension (HP:0100817)1.87442017
134Camptodactyly of toe (HP:0001836)1.87270380
135Abnormality of skeletal muscle fiber size (HP:0012084)1.86964229
136Pterygium (HP:0001059)1.86900295
137Cubitus valgus (HP:0002967)1.86394523
138Venous abnormality (HP:0002624)1.85950285
139Abnormality of primary teeth (HP:0006481)1.84443846
140Short hallux (HP:0010109)1.84058605
141Platyspondyly (HP:0000926)1.82756370
142Knee flexion contracture (HP:0006380)1.82729601
143Disproportionate tall stature (HP:0001519)1.82207765
144Abnormality of skull ossification (HP:0002703)1.81180328
145Abnormality of the anterior chamber (HP:0000593)1.81112991
146Attenuation of retinal blood vessels (HP:0007843)1.79430702
147Hyperkalemia (HP:0002153)1.79326738
148Hypophosphatemia (HP:0002148)1.78930617
149Protruding ear (HP:0000411)1.78650079
150Hip contracture (HP:0003273)1.77798972
151Preaxial foot polydactyly (HP:0001841)1.77645238
152Dysostosis multiplex (HP:0000943)1.77450785
153Short 4th metacarpal (HP:0010044)1.76801661
154Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.76801661
155Buphthalmos (HP:0000557)1.74090553
156Aplasia/Hypoplasia of the lens (HP:0008063)1.73774340
157Synostosis involving the elbow (HP:0003938)1.73296006
158Humeroradial synostosis (HP:0003041)1.73296006
159Osteopenia (HP:0000938)1.72636733
160Hypoplastic ischia (HP:0003175)1.71379292
161Limited hip movement (HP:0008800)1.70627996
162Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.70511387
163Microglossia (HP:0000171)1.70176643

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR26.60646056
2LATS14.45638463
3MOS3.99279791
4TRIB33.87163628
5PDGFRA3.65257888
6TTN3.42466781
7GRK73.33561170
8LATS23.15694202
9SIK12.85042652
10EPHB22.78623163
11PKN22.69687910
12EPHA32.53246041
13TGFBR22.29676569
14EPHB12.08533492
15MAPK152.03336863
16GRK51.98315756
17PTK61.92127845
18FGFR21.84551661
19RIPK41.84393065
20PAK21.83939591
21MAP3K61.79433776
22ARAF1.68074259
23CAMK2B1.66269078
24BMX1.61619418
25FER1.57504905
26STK31.51964423
27RIPK11.50145834
28MAP3K131.48057014
29FGFR11.44324776
30MAP3K31.42174610
31TYK21.41778608
32PIK3CA1.36811313
33LRRK21.35961697
34KIT1.30062644
35PAK41.23687450
36ROCK11.20458525
37PDGFRB1.19270255
38PAK31.17778966
39DMPK1.17381882
40TBK11.17124645
41BLK1.14437453
42NEK91.11562415
43MST1R1.08976856
44RPS6KA61.08381012
45NTRK11.06929577
46ERBB31.06604986
47FGFR40.99284052
48ROCK20.99199497
49STK100.98414801
50ERN10.95216237
51PRKCH0.93806029
52MYLK0.93378233
53FRK0.93321074
54PTK20.92295977
55MET0.91911081
56MAP3K140.91631994
57KSR20.87695594
58EEF2K0.87136848
59NLK0.84526630
60ICK0.84313150
61TESK10.83362548
62OBSCN0.82231285
63ABL20.80879772
64PDK10.76590458
65PLK20.75916827
66PIM20.75626509
67TRPM70.75566388
68PDPK10.74369572
69ILK0.72905044
70GSK3A0.71665032
71CAMKK10.71173913
72TAOK20.70016910
73MTOR0.69327843
74MARK20.68095567
75JAK10.67770025
76MAP3K10.67194252
77MAP2K30.67191189
78SMG10.67110544
79LMTK20.66845231
80JAK30.65432639
81FLT30.65333402
82ADRBK10.64770222
83IRAK30.63741638
84CDC42BPA0.63311371
85CDK60.62728257
86CSNK1G10.61794748
87MAPK40.61737849
88NUAK10.61315128
89PRKD10.60924128
90PRKCE0.60658029
91STK38L0.59907786
92IKBKE0.58068234
93JAK20.55997978
94INSR0.55832454
95CAMK1G0.55315353
96MAP2K20.54877112
97FGFR30.54082588
98MAPKAPK50.53630561
99PRPF4B0.53160231
100IRAK20.52812261
101PRKD20.51849937
102MAP3K100.51791652
103SYK0.50610456
104PTK2B0.49604187
105SRC0.47702985
106IRAK10.47078533
107MAP3K20.47020384
108ZAP700.46845525
109MAPK70.44760186
110CAMK1D0.43915333
111RET0.40365666
112RPS6KA20.39915017
113ERBB20.39648278
114PHKG20.39620738
115PHKG10.39620738
116RPS6KA40.39544905
117NTRK20.38955284
118PRKCD0.38694039
119PNCK0.36484196
120ITK0.36089519
121MAP2K10.35620085
122MAPK120.34970337
123CSNK1A1L0.34787440
124IGF1R0.34201930
125EIF2AK20.33964504
126MAPK30.33523381
127NEK60.33478203
128CSK0.31957980
129STK380.31284889
130MKNK10.30422601
131NME20.30284488
132PRKD30.29917431
133KSR10.29386280
134PIK3CG0.28730730
135MAP3K70.28564510
136RPS6KC10.28299967
137RPS6KL10.28299967
138TYRO30.27777149
139WNK10.27757515
140FYN0.27112503
141PAK60.26342305
142PDK20.26261059
143CSF1R0.24592968
144HIPK20.24031391
145AKT20.23426042
146PLK30.23249878
147MAPK10.21626812
148MAPK90.21471603
149PRKCG0.21426657

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.79435239
2Protein digestion and absorption_Homo sapiens_hsa049743.71904892
3Focal adhesion_Homo sapiens_hsa045102.98333606
4Nitrogen metabolism_Homo sapiens_hsa009102.89444301
5Other glycan degradation_Homo sapiens_hsa005112.61972801
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.57448456
7Basal cell carcinoma_Homo sapiens_hsa052172.39892713
8Lysosome_Homo sapiens_hsa041422.17981291
9Amoebiasis_Homo sapiens_hsa051462.17959058
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.15353340
11TGF-beta signaling pathway_Homo sapiens_hsa043502.12268308
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.08690718
13Malaria_Homo sapiens_hsa051442.02949162
14Proteoglycans in cancer_Homo sapiens_hsa052052.02483022
15Dilated cardiomyopathy_Homo sapiens_hsa054141.97767393
16Hippo signaling pathway_Homo sapiens_hsa043901.94808980
17Hedgehog signaling pathway_Homo sapiens_hsa043401.89782008
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.87985178
19Melanogenesis_Homo sapiens_hsa049161.78728753
20Adherens junction_Homo sapiens_hsa045201.68723689
21PI3K-Akt signaling pathway_Homo sapiens_hsa041511.60058138
22Wnt signaling pathway_Homo sapiens_hsa043101.59819885
23Retinol metabolism_Homo sapiens_hsa008301.54367171
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.50168929
25Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.40017345
26Circadian rhythm_Homo sapiens_hsa047101.36245991
27Melanoma_Homo sapiens_hsa052181.33607417
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.33106660
29Axon guidance_Homo sapiens_hsa043601.29428117
30MicroRNAs in cancer_Homo sapiens_hsa052061.24723264
31Staphylococcus aureus infection_Homo sapiens_hsa051501.22262137
32Small cell lung cancer_Homo sapiens_hsa052221.18954120
33Platelet activation_Homo sapiens_hsa046111.15711013
34Prostate cancer_Homo sapiens_hsa052151.13990819
35Glioma_Homo sapiens_hsa052141.11971095
36Regulation of actin cytoskeleton_Homo sapiens_hsa048101.11434685
37Pathways in cancer_Homo sapiens_hsa052001.10475389
38Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.09338688
39Chronic myeloid leukemia_Homo sapiens_hsa052201.08294436
40Estrogen signaling pathway_Homo sapiens_hsa049151.07720182
41Tight junction_Homo sapiens_hsa045301.07591886
42Rap1 signaling pathway_Homo sapiens_hsa040151.07554059
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03793774
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03279837
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02255029
46Galactose metabolism_Homo sapiens_hsa000520.99442695
47Bladder cancer_Homo sapiens_hsa052190.98574648
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97890737
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97475127
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94535313
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.94213146
52Inositol phosphate metabolism_Homo sapiens_hsa005620.94049572
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93159465
54Gastric acid secretion_Homo sapiens_hsa049710.91629862
55Pentose phosphate pathway_Homo sapiens_hsa000300.91577223
56Rheumatoid arthritis_Homo sapiens_hsa053230.90898914
57Renal cell carcinoma_Homo sapiens_hsa052110.88893251
58Colorectal cancer_Homo sapiens_hsa052100.88440541
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87896760
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86505005
61Leishmaniasis_Homo sapiens_hsa051400.84658955
62GnRH signaling pathway_Homo sapiens_hsa049120.81162041
63Pancreatic cancer_Homo sapiens_hsa052120.80942539
64Gap junction_Homo sapiens_hsa045400.79939699
65Thyroid hormone synthesis_Homo sapiens_hsa049180.79890438
66Ovarian steroidogenesis_Homo sapiens_hsa049130.78890152
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78296133
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.78020371
69Ras signaling pathway_Homo sapiens_hsa040140.77037541
70HTLV-I infection_Homo sapiens_hsa051660.76721331
71Fructose and mannose metabolism_Homo sapiens_hsa000510.73821758
72Choline metabolism in cancer_Homo sapiens_hsa052310.73618825
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73384732
74Vibrio cholerae infection_Homo sapiens_hsa051100.71821854
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71088809
76Pertussis_Homo sapiens_hsa051330.70793510
77Viral myocarditis_Homo sapiens_hsa054160.69663452
78Tuberculosis_Homo sapiens_hsa051520.69483514
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.68927179
80Phototransduction_Homo sapiens_hsa047440.68669300
81Renin secretion_Homo sapiens_hsa049240.64665208
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63369538
83Endometrial cancer_Homo sapiens_hsa052130.63150221
84Oxytocin signaling pathway_Homo sapiens_hsa049210.62521267
85Notch signaling pathway_Homo sapiens_hsa043300.62316737
86Toxoplasmosis_Homo sapiens_hsa051450.62183572
87Sphingolipid metabolism_Homo sapiens_hsa006000.61638109
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61350173
89cAMP signaling pathway_Homo sapiens_hsa040240.59498146
90Salivary secretion_Homo sapiens_hsa049700.58942160
91Bile secretion_Homo sapiens_hsa049760.58561959
92TNF signaling pathway_Homo sapiens_hsa046680.58326510
93Endocytosis_Homo sapiens_hsa041440.57407683
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.57195452
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56383478
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56297547
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55347345
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.54203838
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52310463
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.50710733
101Circadian entrainment_Homo sapiens_hsa047130.50600392
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50539778
103Cocaine addiction_Homo sapiens_hsa050300.50114198
104Olfactory transduction_Homo sapiens_hsa047400.49829039
105Phagosome_Homo sapiens_hsa041450.49646653
106Insulin resistance_Homo sapiens_hsa049310.48913261
107Osteoclast differentiation_Homo sapiens_hsa043800.47848821
108Prion diseases_Homo sapiens_hsa050200.47295864
109Tyrosine metabolism_Homo sapiens_hsa003500.46645301
110Amphetamine addiction_Homo sapiens_hsa050310.46560314
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.46139456
112MAPK signaling pathway_Homo sapiens_hsa040100.46001818
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45022304
114FoxO signaling pathway_Homo sapiens_hsa040680.44929003
115Arachidonic acid metabolism_Homo sapiens_hsa005900.44730826
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44156008
117Calcium signaling pathway_Homo sapiens_hsa040200.44073810
118Legionellosis_Homo sapiens_hsa051340.42805133
119mTOR signaling pathway_Homo sapiens_hsa041500.42364587
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40693621
121Lysine degradation_Homo sapiens_hsa003100.40358130
122Salmonella infection_Homo sapiens_hsa051320.39702712
123Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39422603
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38503577
125Hepatitis B_Homo sapiens_hsa051610.37019020
126B cell receptor signaling pathway_Homo sapiens_hsa046620.36852164
127Collecting duct acid secretion_Homo sapiens_hsa049660.35392407
128Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34791339
129Complement and coagulation cascades_Homo sapiens_hsa046100.34624019
130PPAR signaling pathway_Homo sapiens_hsa033200.34234711
131Cholinergic synapse_Homo sapiens_hsa047250.33863559
132Vitamin digestion and absorption_Homo sapiens_hsa049770.33779867
133VEGF signaling pathway_Homo sapiens_hsa043700.32510143
134Chemokine signaling pathway_Homo sapiens_hsa040620.31990368
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.31776504
136HIF-1 signaling pathway_Homo sapiens_hsa040660.30493287
137Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.30078260

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