COL9A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. Mutations in this gene are associated with multiple epiphyseal dysplasia type 3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cartilage development involved in endochondral bone morphogenesis (GO:0060351)8.29742678
2cell aggregation (GO:0098743)7.83703518
3cartilage condensation (GO:0001502)7.83703518
4chondrocyte development (GO:0002063)7.80762507
5thyroid gland development (GO:0030878)7.03334571
6limb bud formation (GO:0060174)6.49627159
7mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)6.27338122
8sulfate transmembrane transport (GO:1902358)6.03183674
9central nervous system myelination (GO:0022010)5.87492601
10axon ensheathment in central nervous system (GO:0032291)5.87492601
11keratan sulfate catabolic process (GO:0042340)5.71271065
12cellular response to gonadotropin stimulus (GO:0071371)5.15691374
13collagen fibril organization (GO:0030199)5.12586345
14sulfate transport (GO:0008272)4.99894489
15positive regulation of hormone metabolic process (GO:0032352)4.95422543
16myelination (GO:0042552)4.67386978
17ensheathment of neurons (GO:0007272)4.65045921
18axon ensheathment (GO:0008366)4.65045921
19regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.52598839
20negative regulation of microtubule polymerization (GO:0031115)4.37941690
21cartilage development (GO:0051216)4.22426328
22chondrocyte differentiation (GO:0002062)4.19870388
23notochord development (GO:0030903)4.16633647
24regulation of extracellular matrix disassembly (GO:0010715)4.15984882
25cholesterol biosynthetic process (GO:0006695)4.14133303
26eye photoreceptor cell differentiation (GO:0001754)4.09103761
27photoreceptor cell differentiation (GO:0046530)4.09103761
28positive regulation of neurological system process (GO:0031646)4.05490744
29mesenchymal to epithelial transition (GO:0060231)4.03592346
30oligodendrocyte differentiation (GO:0048709)4.00475885
31fatty acid elongation (GO:0030497)3.98674679
32chondroitin sulfate biosynthetic process (GO:0030206)3.95480181
33regulation of cholesterol biosynthetic process (GO:0045540)3.93750687
34transmission of nerve impulse (GO:0019226)3.89251390
35planar cell polarity pathway involved in neural tube closure (GO:0090179)3.84874791
36pattern specification involved in kidney development (GO:0061004)3.82504606
37endochondral ossification (GO:0001958)3.76148559
38replacement ossification (GO:0036075)3.76148559
39regulation of stem cell maintenance (GO:2000036)3.75375689
40bone trabecula formation (GO:0060346)3.75017082
41dermatan sulfate biosynthetic process (GO:0030208)3.74773624
42positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.74080003
43lateral sprouting from an epithelium (GO:0060601)3.73341008
44* collagen catabolic process (GO:0030574)3.70297766
45positive regulation of extracellular matrix organization (GO:1903055)3.70147703
46embryonic skeletal joint morphogenesis (GO:0060272)3.69087958
47lens fiber cell development (GO:0070307)3.68002177
48sterol biosynthetic process (GO:0016126)3.64860319
49proteoglycan metabolic process (GO:0006029)3.59324326
50* collagen metabolic process (GO:0032963)3.55943268
51L-amino acid import (GO:0043092)3.51359062
52positive regulation of chondrocyte differentiation (GO:0032332)3.50506289
53positive regulation of cellular amine metabolic process (GO:0033240)3.49894224
54detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.49395771
55endocardial cushion morphogenesis (GO:0003203)3.46415363
56myelination in peripheral nervous system (GO:0022011)3.46119220
57peripheral nervous system axon ensheathment (GO:0032292)3.46119220
58regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.45695499
59dermatan sulfate metabolic process (GO:0030205)3.41358559
60hydrogen peroxide catabolic process (GO:0042744)3.41322141
61positive regulation of cartilage development (GO:0061036)3.40580199
62negative regulation of catenin import into nucleus (GO:0035414)3.39992814
63negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.38979864
64response to gonadotropin (GO:0034698)3.37767247
65* multicellular organismal catabolic process (GO:0044243)3.37499488
66* multicellular organismal macromolecule metabolic process (GO:0044259)3.32581079
67positive regulation of mesonephros development (GO:0061213)3.32259705
68paraxial mesoderm development (GO:0048339)3.31644100
69import into cell (GO:0098657)3.29993158
70regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.28601658
71glycerophospholipid catabolic process (GO:0046475)3.27838120
72response to redox state (GO:0051775)3.27157407
73maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.27013328
74protein retention in ER lumen (GO:0006621)3.24733209
75regulation of collateral sprouting (GO:0048670)3.24359448
76iron ion import (GO:0097286)3.23557530
77regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.21835776
78basement membrane organization (GO:0071711)3.21669080
79negative regulation of metanephros development (GO:0072217)3.21450426
80sphingomyelin metabolic process (GO:0006684)3.21277044
81regulation of response to osmotic stress (GO:0047484)3.20984909
82isoprenoid biosynthetic process (GO:0008299)3.20921579
83G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.20420659
84substantia nigra development (GO:0021762)3.18242378
85negative regulation of neurotransmitter secretion (GO:0046929)3.14444523
86skeletal system development (GO:0001501)3.14274292
87negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.11724754
88* multicellular organismal metabolic process (GO:0044236)3.11190069
89regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.10906843
90hypotonic response (GO:0006971)3.09042213
91otic vesicle formation (GO:0030916)3.08588768
92chondroitin sulfate metabolic process (GO:0030204)3.07788873
93keratan sulfate biosynthetic process (GO:0018146)3.07756939
94convergent extension (GO:0060026)3.07481814
95locomotory exploration behavior (GO:0035641)3.06528266
96positive regulation of hormone biosynthetic process (GO:0046886)3.03972151
97regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.03648629
98amino acid import (GO:0043090)3.03215577
99semaphorin-plexin signaling pathway (GO:0071526)3.02996314
100long-chain fatty acid biosynthetic process (GO:0042759)2.98166391
101proline biosynthetic process (GO:0006561)2.96597018
102cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.96228818
103lung epithelium development (GO:0060428)2.96000025
104regulation of steroid hormone biosynthetic process (GO:0090030)2.95867894
105activated T cell proliferation (GO:0050798)2.95798757
106mesenchyme morphogenesis (GO:0072132)2.95159984
107cell-cell junction maintenance (GO:0045217)2.93866377
108* extracellular matrix disassembly (GO:0022617)2.92057640
109metanephric nephron tubule development (GO:0072234)2.88225693
110metanephric tubule development (GO:0072170)2.88225693
111myelin assembly (GO:0032288)2.87276417
112regulation of chondrocyte differentiation (GO:0032330)2.87237772
113negative regulation of axon extension (GO:0030517)2.86892171
114regulation of apoptotic cell clearance (GO:2000425)2.84741673
115regulation of myelination (GO:0031641)2.84004996
116regulation of apoptotic process involved in morphogenesis (GO:1902337)2.83951629
117neuronal ion channel clustering (GO:0045161)2.82918678
118endothelial cell morphogenesis (GO:0001886)2.82548894
119regulation of somitogenesis (GO:0014807)2.81914252
120connective tissue development (GO:0061448)2.81739553
121mesonephros development (GO:0001823)2.79129699
122proline metabolic process (GO:0006560)2.78226247
123negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.78104534
124regulation of catenin import into nucleus (GO:0035412)2.78019654
125regulation of mesonephros development (GO:0061217)2.76971344
126heterochromatin organization (GO:0070828)2.76955368
127phenol-containing compound metabolic process (GO:0018958)2.75441292
128peripheral nervous system development (GO:0007422)2.75274129
129sodium ion export (GO:0071436)2.75000527
130glycoprotein metabolic process (GO:0009100)2.72857950
131metanephric epithelium development (GO:0072207)2.72651821
132regulation of glucose import in response to insulin stimulus (GO:2001273)2.71058074
133regulation of extracellular matrix organization (GO:1903053)2.71008485
134metanephric nephron epithelium development (GO:0072243)2.70698433
135Rap protein signal transduction (GO:0032486)2.70542819
136positive regulation of dendritic spine morphogenesis (GO:0061003)2.69587889
137specification of organ identity (GO:0010092)2.69109757
138negative regulation of chondrocyte differentiation (GO:0032331)2.67410253
139Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.66486070
140neuron cell-cell adhesion (GO:0007158)2.64027372
141glycosaminoglycan biosynthetic process (GO:0006024)2.63920819
142ectodermal placode formation (GO:0060788)2.63682028
143detection of mechanical stimulus involved in sensory perception (GO:0050974)2.63469000
144positive regulation of catenin import into nucleus (GO:0035413)2.62930681
145urogenital system development (GO:0001655)2.62418571
146plasma lipoprotein particle assembly (GO:0034377)2.61176402
147aminoglycan biosynthetic process (GO:0006023)2.60226243
148positive regulation of actin filament depolymerization (GO:0030836)2.60178453
149layer formation in cerebral cortex (GO:0021819)2.59434437
150regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.58900515
151adhesion of symbiont to host cell (GO:0044650)2.58873028
152virion attachment to host cell (GO:0019062)2.58873028
153ossification (GO:0001503)2.58789075
154regulation of hormone metabolic process (GO:0032350)2.57978915
155regulation of cartilage development (GO:0061035)2.57542949
156nephron tubule formation (GO:0072079)2.57259526
157very-low-density lipoprotein particle assembly (GO:0034379)2.57016813
158regulation of bile acid biosynthetic process (GO:0070857)2.55396618
159regulation of cholesterol homeostasis (GO:2000188)2.55066517
160cellular response to prostaglandin stimulus (GO:0071379)2.54650119
161regulation of cholesterol metabolic process (GO:0090181)2.54326530
162cerebral cortex radially oriented cell migration (GO:0021799)2.54120945
163regulation of gene silencing by RNA (GO:0060966)2.53468207
164regulation of posttranscriptional gene silencing (GO:0060147)2.53468207
165regulation of gene silencing by miRNA (GO:0060964)2.53468207
166epithelial cell morphogenesis (GO:0003382)2.53465689
167response to follicle-stimulating hormone (GO:0032354)2.51359487
168* extracellular matrix organization (GO:0030198)2.51306035
169regulation of cell maturation (GO:1903429)2.51294911
170regulation of alkaline phosphatase activity (GO:0010692)2.50727935
171establishment of apical/basal cell polarity (GO:0035089)2.50288615
172embryonic retina morphogenesis in camera-type eye (GO:0060059)2.50200048
173regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.49330406
174peptidyl-glutamic acid carboxylation (GO:0017187)2.48032833
175protein carboxylation (GO:0018214)2.48032833
176regulation of establishment of planar polarity (GO:0090175)2.47785142
177neuron projection regeneration (GO:0031102)2.46711468
178positive regulation of synapse maturation (GO:0090129)2.46459107
179hormone biosynthetic process (GO:0042446)2.46198697
180regulation of mammary gland epithelial cell proliferation (GO:0033599)2.43084671
181lung-associated mesenchyme development (GO:0060484)2.39810365
182positive regulation of smoothened signaling pathway (GO:0045880)2.39024540
183protein-lipid complex assembly (GO:0065005)2.37567396
184non-canonical Wnt signaling pathway (GO:0035567)2.36163604
185negative regulation of sodium ion transport (GO:0010766)2.35415986
186branching involved in salivary gland morphogenesis (GO:0060445)2.33456378
187protein complex localization (GO:0031503)2.33121040
188L-alpha-amino acid transmembrane transport (GO:1902475)2.32706067
189anterior/posterior axis specification, embryo (GO:0008595)2.32122220
190COPI coating of Golgi vesicle (GO:0048205)2.29860409
191Golgi transport vesicle coating (GO:0048200)2.29860409
192thyroid hormone generation (GO:0006590)18.4415337
193thyroid hormone metabolic process (GO:0042403)14.6215196

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.39896909
2AR_21572438_ChIP-Seq_LNCaP_Human3.39501777
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.89497657
4ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.74656395
5* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.72872877
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.64543034
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.63849712
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.56646172
9ZFP281_18757296_ChIP-ChIP_E14_Mouse2.51031270
10* LXR_22292898_ChIP-Seq_THP-1_Human2.47303686
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.47131138
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44509541
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44509541
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.36274416
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.36245234
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.31038670
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27733602
18* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.21497836
19KDM2B_26808549_Chip-Seq_K562_Human2.17612624
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.15435801
21ZNF263_19887448_ChIP-Seq_K562_Human2.14379854
22SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.13069537
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.12862588
24JARID2_20075857_ChIP-Seq_MESCs_Mouse2.10553288
25PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.07568210
26WT1_19549856_ChIP-ChIP_CCG9911_Human2.01949350
27GBX2_23144817_ChIP-Seq_PC3_Human1.98526072
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.97012158
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.95262045
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.93742284
31EZH2_22144423_ChIP-Seq_EOC_Human1.91850710
32KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.90916774
33KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.90916774
34KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.90916774
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.89272851
36* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85846981
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.84078333
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.79602145
39CLOCK_20551151_ChIP-Seq_293T_Human1.78323450
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.77941799
41* RACK7_27058665_Chip-Seq_MCF-7_Human1.77733950
42* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.77482352
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.74544492
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72597516
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69350263
46ZFP281_27345836_Chip-Seq_ESCs_Mouse1.68984538
47SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.68370633
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67450765
49MYC_22102868_ChIP-Seq_BL_Human1.66537720
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65915309
51EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.65573302
52ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.65015235
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.62944706
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62194671
55POU5F1_16518401_ChIP-PET_MESCs_Mouse1.58244844
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57466726
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.56998278
58CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.56360126
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.55637225
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55315307
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.55212786
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55061793
63EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.52153102
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51942542
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51886005
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51886005
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47337195
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47173189
69* TCF7_22412390_ChIP-Seq_EML_Mouse1.46106283
70DROSHA_22980978_ChIP-Seq_HELA_Human1.45449677
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44679388
72* SMC4_20622854_ChIP-Seq_HELA_Human1.43033123
73EP300_21415370_ChIP-Seq_HL-1_Mouse1.42730262
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39456847
75* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38939494
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38553967
77SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31624354
78SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.31380686
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.31081639
80* P68_20966046_ChIP-Seq_HELA_Human1.29830242
81* FOXA2_19822575_ChIP-Seq_HepG2_Human1.27947980
82ESR1_21235772_ChIP-Seq_MCF-7_Human1.27315233
83CREB1_26743006_Chip-Seq_LNCaP_Human1.27185020
84ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26858349
85TP63_17297297_ChIP-ChIP_HaCaT_Human1.26688036
86DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26620248
87ER_23166858_ChIP-Seq_MCF-7_Human1.26219986
88ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25836183
89NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.25776532
90RING1B_27294783_Chip-Seq_ESCs_Mouse1.25764630
91TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24780443
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24571407
93* KDM2B_26808549_Chip-Seq_DND41_Human1.24306138
94TAF15_26573619_Chip-Seq_HEK293_Human1.24115200
95DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22571629
96TET1_21451524_ChIP-Seq_MESCs_Mouse1.22526564
97NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.22359446
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21774036
99SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.21761204
100TP53_18474530_ChIP-ChIP_U2OS_Human1.21399670
101PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21182714
102ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20976785
103FOXM1_23109430_ChIP-Seq_U2OS_Human1.20867325
104SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20786957
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20778751
106BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20598852
107SOX2_21211035_ChIP-Seq_LN229_Gbm1.18986606
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18019603
109CTCF_27219007_Chip-Seq_Bcells_Human1.17962740
110RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17920915
111VDR_24787735_ChIP-Seq_THP-1_Human1.17809815
112NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17792482
113HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16846325
114EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.16808047
115CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16537578
116WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16446155
117NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16339184
118STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16139946
119ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15740512
120RING1B_27294783_Chip-Seq_NPCs_Mouse1.15340400
121TP53_22127205_ChIP-Seq_IMR90_Human1.15320316
122NANOG_21062744_ChIP-ChIP_HESCs_Human1.14898839
123KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14740784
124FUS_26573619_Chip-Seq_HEK293_Human1.14642486
125TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14629185
126RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14258201
127KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13750428
128SA1_27219007_Chip-Seq_ERYTHROID_Human1.12239520
129NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11663409
130NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11663409
131TCF3_18692474_ChIP-Seq_MEFs_Mouse1.11649082
132SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.11542834
133SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11221431
134SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.10838934
135RXR_22158963_ChIP-Seq_LIVER_Mouse1.10243668
136P300_19829295_ChIP-Seq_ESCs_Human1.10179995
137SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.09941386
138SALL1_21062744_ChIP-ChIP_HESCs_Human1.09573251
139MYC_18555785_ChIP-Seq_MESCs_Mouse1.09331678
140P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09274348
141KAP1_27257070_Chip-Seq_ESCs_Mouse1.09241614
142ISL1_27105846_Chip-Seq_CPCs_Mouse1.09002927
143ESR1_20079471_ChIP-ChIP_T-47D_Human1.07848498
144MYC_19079543_ChIP-ChIP_MESCs_Mouse1.07193802
145* RARB_27405468_Chip-Seq_BRAIN_Mouse1.06759652
146OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06183957
147CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06112186
148DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05610203
149RARA_24833708_ChIP-Seq_LIVER_Mouse1.05148739
150NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04781708
151* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04532964
152NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03938435
153STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.03286771
154RXR_22108803_ChIP-Seq_LS180_Human1.01754788
155FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01686877
156TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01339809
157ERG_21242973_ChIP-ChIP_JURKAT_Human1.00131004
158CJUN_26792858_Chip-Seq_BT549_Human0.99782001
159NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99644663
160POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99377723
161AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99279103
162TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97754701
163CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.97641409
164ARNT_22903824_ChIP-Seq_MCF-7_Human0.97093079
165TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96592255
166STAT3_23295773_ChIP-Seq_U87_Human0.96097487
167NANOG_18555785_Chip-Seq_ESCs_Mouse0.96017594
168SMAD_19615063_ChIP-ChIP_OVARY_Human0.95304057
169AHR_22903824_ChIP-Seq_MCF-7_Human0.94996068
170MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93778397
171* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93765217
172TP53_20018659_ChIP-ChIP_R1E_Mouse0.93757035
173TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93218592
174SMAD4_21799915_ChIP-Seq_A2780_Human0.92976100
175MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92302585
176UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90610023
177* RUNX2_22187159_ChIP-Seq_PCA_Human0.89180143
178YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87759173

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000681_abnormal_thyroid_gland6.91692938
2MP0004134_abnormal_chest_morphology5.72966145
3MP0002876_abnormal_thyroid_physiology4.25504924
4MP0002282_abnormal_trachea_morphology3.68646169
5MP0002933_joint_inflammation3.40684333
6MP0005503_abnormal_tendon_morphology3.39822501
7MP0009250_abnormal_appendicular_skeleto3.33584071
8MP0004858_abnormal_nervous_system3.07417813
9MP0000163_abnormal_cartilage_morphology2.94341108
10MP0001299_abnormal_eye_distance/2.87933658
11MP0000762_abnormal_tongue_morphology2.77165417
12MP0000566_synostosis2.74264220
13MP0009780_abnormal_chondrocyte_physiolo2.69631041
14MP0001485_abnormal_pinna_reflex2.68088111
15MP0002115_abnormal_skeleton_extremities2.50668840
16MP0001963_abnormal_hearing_physiology2.44536128
17MP0000462_abnormal_digestive_system2.34168037
18MP0004885_abnormal_endolymph2.26825657
19MP0002089_abnormal_postnatal_growth/wei2.23215712
20MP0000920_abnormal_myelination2.17025294
21MP0000026_abnormal_inner_ear2.16003773
22MP0004272_abnormal_basement_membrane2.10323603
23MP0005508_abnormal_skeleton_morphology2.06286613
24MP0009384_cardiac_valve_regurgitation2.01276301
25MP0008569_lethality_at_weaning1.99994554
26MP0002113_abnormal_skeleton_development1.93962769
27MP0002896_abnormal_bone_mineralization1.80495142
28MP0003937_abnormal_limbs/digits/tail_de1.79890278
29MP0003122_maternal_imprinting1.79493284
30MP0003879_abnormal_hair_cell1.78381481
31MP0003878_abnormal_ear_physiology1.77628531
32MP0005377_hearing/vestibular/ear_phenot1.77628531
33MP0003705_abnormal_hypodermis_morpholog1.76350236
34MP0002116_abnormal_craniofacial_bone1.75750610
35MP0002109_abnormal_limb_morphology1.73836759
36MP0003755_abnormal_palate_morphology1.71032393
37MP0001270_distended_abdomen1.70457259
38MP0000049_abnormal_middle_ear1.68160623
39MP0008438_abnormal_cutaneous_collagen1.66581338
40MP0003690_abnormal_glial_cell1.63557922
41MP0004742_abnormal_vestibular_system1.63187201
42MP0002249_abnormal_larynx_morphology1.62400096
43MP0005076_abnormal_cell_differentiation1.62111274
44MP0002233_abnormal_nose_morphology1.62057938
45MP0003283_abnormal_digestive_organ1.57723605
46MP0005623_abnormal_meninges_morphology1.55472231
47MP0010030_abnormal_orbit_morphology1.51044371
48MP0005409_darkened_coat_color1.50874173
49MP0002108_abnormal_muscle_morphology1.49567718
50MP0000778_abnormal_nervous_system1.48920268
51MP0002932_abnormal_joint_morphology1.44937737
52MP0003890_abnormal_embryonic-extraembry1.44422181
53MP0005390_skeleton_phenotype1.42017799
54MP0003385_abnormal_body_wall1.40684717
55MP0000432_abnormal_head_morphology1.38708305
56MP0003938_abnormal_ear_development1.38438102
57MP0009672_abnormal_birth_weight1.36833915
58MP0005171_absent_coat_pigmentation1.35732213
59MP0000428_abnormal_craniofacial_morphol1.32849647
60MP0005248_abnormal_Harderian_gland1.32146605
61MP0003115_abnormal_respiratory_system1.31999484
62MP0000383_abnormal_hair_follicle1.28795942
63MP0002111_abnormal_tail_morphology1.25039324
64MP0001501_abnormal_sleep_pattern1.23927790
65MP0001849_ear_inflammation1.21897334
66MP0003566_abnormal_cell_adhesion1.20191495
67MP0003119_abnormal_digestive_system1.18358948
68MP0000678_abnormal_parathyroid_gland1.17863717
69MP0001486_abnormal_startle_reflex1.17322349
70MP0001915_intracranial_hemorrhage1.14292543
71MP0002938_white_spotting1.12021453
72MP0003880_abnormal_central_pattern1.11849264
73MP0004133_heterotaxia1.11117460
74MP0002114_abnormal_axial_skeleton1.10678974
75MP0010678_abnormal_skin_adnexa1.09446934
76MP0002254_reproductive_system_inflammat1.07535913
77MP0003942_abnormal_urinary_system1.07352323
78MP0001533_abnormal_skeleton_physiology1.07011209
79MP0000534_abnormal_ureter_morphology1.06849820
80MP0005058_abnormal_lysosome_morphology1.04933742
81MP0000537_abnormal_urethra_morphology1.03570925
82MP0003935_abnormal_craniofacial_develop1.03164704
83MP0002272_abnormal_nervous_system1.02197650
84MP0002697_abnormal_eye_size1.00034279
85MP0003795_abnormal_bone_structure0.99532257
86MP0003646_muscle_fatigue0.98451354
87MP0003172_abnormal_lysosome_physiology0.97866191
88MP0004043_abnormal_pH_regulation0.96888334
89MP0001346_abnormal_lacrimal_gland0.96644740
90MP0003567_abnormal_fetal_cardiomyocyte0.95330294
91MP0008004_abnormal_stomach_pH0.94865362
92MP0003941_abnormal_skin_development0.94686702
93MP0003861_abnormal_nervous_system0.93861767
94MP0003634_abnormal_glial_cell0.91471603
95MP0003868_abnormal_feces_composition0.90307660
96MP0003136_yellow_coat_color0.87788795
97MP0002085_abnormal_embryonic_tissue0.86282707
98MP0000751_myopathy0.85591164
99MP0002092_abnormal_eye_morphology0.85588534
100MP0001340_abnormal_eyelid_morphology0.85519314
101MP0005365_abnormal_bile_salt0.85312641
102MP0004264_abnormal_extraembryonic_tissu0.85047607
103MP0002752_abnormal_somatic_nervous0.84756963
104MP0001286_abnormal_eye_development0.84489641
105MP0001348_abnormal_lacrimal_gland0.84166996
106MP0004185_abnormal_adipocyte_glucose0.84010493
107MP0005408_hypopigmentation0.82272913
108MP0000639_abnormal_adrenal_gland0.80681172
109MP0005257_abnormal_intraocular_pressure0.79791918
110MP0001177_atelectasis0.79503763
111MP0001730_embryonic_growth_arrest0.79165785
112MP0000955_abnormal_spinal_cord0.78568029
113MP0004270_analgesia0.78544170
114MP0001542_abnormal_bone_strength0.78538220
115MP0002184_abnormal_innervation0.78461658
116MP0008260_abnormal_autophagy0.77357499
117MP0000631_abnormal_neuroendocrine_gland0.77163322
118MP0000647_abnormal_sebaceous_gland0.76856501
119MP0005275_abnormal_skin_tensile0.76795474
120MP0002064_seizures0.75532781
121MP0001293_anophthalmia0.75218375
122MP0005381_digestive/alimentary_phenotyp0.75180285
123MP0002822_catalepsy0.74996348
124MP0004381_abnormal_hair_follicle0.74586907
125MP0003123_paternal_imprinting0.73709105
126MP0001943_abnormal_respiration0.73675988
127MP0005380_embryogenesis_phenotype0.73397324
128MP0001672_abnormal_embryogenesis/_devel0.73397324
129MP0002084_abnormal_developmental_patter0.72099576
130MP0006292_abnormal_olfactory_placode0.69499134
131MP0002882_abnormal_neuron_morphology0.69060642
132MP0001905_abnormal_dopamine_level0.68464282
133MP0004233_abnormal_muscle_weight0.68113133
134MP0004197_abnormal_fetal_growth/weight/0.67924705
135MP0004859_abnormal_synaptic_plasticity0.67132842
136MP0003111_abnormal_nucleus_morphology0.67067435
137MP0009703_decreased_birth_body0.66589160
138MP0002152_abnormal_brain_morphology0.66076888
139MP0002998_abnormal_bone_remodeling0.66059370
140MP0003698_abnormal_male_reproductive0.65519615
141MP0003121_genomic_imprinting0.65366493
142MP0003984_embryonic_growth_retardation0.65151939
143MP0003329_amyloid_beta_deposits0.65054612
144MP0000579_abnormal_nail_morphology0.63959339
145MP0000372_irregular_coat_pigmentation0.62661298
146MP0000733_abnormal_muscle_development0.61294068
147MP0003632_abnormal_nervous_system0.59787396
148MP0009053_abnormal_anal_canal0.59428895
149MP0002295_abnormal_pulmonary_circulatio0.59098217
150MP0005195_abnormal_posterior_eye0.58173280

Predicted human phenotypes

RankGene SetZ-score
1Goiter (HP:0000853)9.55518536
2Thyroid-stimulating hormone excess (HP:0002925)8.06796406
3* Irregular epiphyses (HP:0010582)7.58126007
4Hypoplastic ischia (HP:0003175)7.45451601
5Vitreoretinal degeneration (HP:0000655)7.35737952
6Abnormality of cochlea (HP:0000375)6.99936887
7Abnormality of the ischium (HP:0003174)6.54037180
8Morphological abnormality of the inner ear (HP:0011390)6.50225916
9Aplasia/Hypoplasia of the pubic bone (HP:0009104)6.47722327
10Pili torti (HP:0003777)6.06738394
11Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)6.01764313
12Hyperthyroidism (HP:0000836)5.06650184
13Flat capital femoral epiphysis (HP:0003370)5.06427986
14Congenital sensorineural hearing impairment (HP:0008527)4.84131662
15Cupped ribs (HP:0000887)4.62301118
16Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)4.58280398
17Absent epiphyses (HP:0010577)4.58280398
18* Small epiphyses (HP:0010585)4.52095472
19* Genu varum (HP:0002970)4.40152732
20Abnormal tarsal ossification (HP:0008369)4.37993342
21Flattened epiphyses (HP:0003071)4.19813681
22Flat acetabular roof (HP:0003180)4.19362184
23Abnormality involving the epiphyses of the lower limbs (HP:0006500)4.05629645
24Abnormality of femoral epiphyses (HP:0006499)4.05629645
25Bronchomalacia (HP:0002780)3.87983254
26Thyroid carcinoma (HP:0002890)3.84534651
27Neonatal short-limb short stature (HP:0008921)3.80736595
28Abnormality of the pubic bones (HP:0003172)3.78638900
29Abnormality of the epiphysis of the femoral head (HP:0010574)3.74172890
30Abnormality of the vertebral endplates (HP:0005106)3.72463403
31* Osteoarthritis (HP:0002758)3.69329658
32Mixed hearing impairment (HP:0000410)3.63372312
33Enlarged epiphyses (HP:0010580)3.60274861
34Barrel-shaped chest (HP:0001552)3.59364383
35Vertebral clefting (HP:0008428)3.53809521
36Abnormal hair laboratory examination (HP:0003328)3.53308030
37* Delayed epiphyseal ossification (HP:0002663)3.51798200
38Abnormality of the femoral head (HP:0003368)3.48827363
39Short femoral neck (HP:0100864)3.39835769
40Protuberant abdomen (HP:0001538)3.35283401
41Hypothyroidism (HP:0000821)3.34294066
42* Mild short stature (HP:0003502)3.30495604
43Abnormal vertebral ossification (HP:0100569)3.30380222
44Arthropathy (HP:0003040)3.27347421
45Metaphyseal cupping (HP:0003021)3.26545374
46Exostoses (HP:0100777)3.21063317
47Bell-shaped thorax (HP:0001591)3.20331317
48Deep venous thrombosis (HP:0002625)3.16273790
49Abnormality of the phalanges of the 2nd finger (HP:0009541)3.15358488
50Vaginal fistula (HP:0004320)3.12687840
51Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.11045399
52Choanal stenosis (HP:0000452)3.10389749
53Irregular vertebral endplates (HP:0003301)3.09099806
54Abnormal foot bone ossification (HP:0010675)3.07425353
55Tracheal stenosis (HP:0002777)3.05439052
56Aplasia/Hypoplasia involving the pelvis (HP:0009103)3.03016897
57Abnormality of carpal bone ossification (HP:0006257)2.92469823
58Hyperparathyroidism (HP:0000843)2.89083378
59Metaphyseal irregularity (HP:0003025)2.88228995
60Hypoplastic pelvis (HP:0008839)2.87576988
61Relative macrocephaly (HP:0004482)2.86375577
62Metaphyseal dysplasia (HP:0100255)2.85823222
63Shallow orbits (HP:0000586)2.83021143
64* Platyspondyly (HP:0000926)2.81646965
65Limited hip movement (HP:0008800)2.80117757
66Turricephaly (HP:0000262)2.79885314
67Glossoptosis (HP:0000162)2.73449623
68Severe Myopia (HP:0011003)2.73015094
69Abnormality of incisor morphology (HP:0011063)2.65258086
70Peripheral hypomyelination (HP:0007182)2.60091098
71Abnormality of the proximal phalanges of the hand (HP:0009834)2.57908199
72* Abnormality of the vitreous humor (HP:0004327)2.55570336
73Aplasia/hypoplasia of the femur (HP:0005613)2.54488351
74Rhizomelia (HP:0008905)2.52115608
75Abnormal hand bone ossification (HP:0010660)2.50763544
76Mesomelia (HP:0003027)2.49573537
77Abnormality of the middle phalanges of the toes (HP:0010183)2.49499202
78Limited elbow extension (HP:0001377)2.44842598
79Coxa vara (HP:0002812)2.43973457
80Waddling gait (HP:0002515)2.43933677
81Hip contracture (HP:0003273)2.43535514
82Lumbar hyperlordosis (HP:0002938)2.42828451
83Arnold-Chiari malformation (HP:0002308)2.42717363
84Coarse facial features (HP:0000280)2.42583588
85Renal duplication (HP:0000075)2.40232899
86Alacrima (HP:0000522)2.39705606
87Hypoplasia of the capital femoral epiphysis (HP:0003090)2.39411602
88Hypoplasia of the odontoid process (HP:0003311)2.36205695
89Abnormal ossification of hand bones (HP:0005921)2.35639372
90Cerebral aneurysm (HP:0004944)2.34098078
91Aplasia involving bones of the upper limbs (HP:0009823)2.31119410
92Aplasia of the phalanges of the hand (HP:0009802)2.31119410
93Aplasia involving bones of the extremities (HP:0009825)2.31119410
94Abnormality of the 2nd finger (HP:0004100)2.29332724
95Short middle phalanx of finger (HP:0005819)2.28231894
96Hyperacusis (HP:0010780)2.25609625
97* Micromelia (HP:0002983)2.19786839
98Constipation (HP:0002019)2.19707092
99Cervical subluxation (HP:0003308)2.18199204
100Hyperpituitarism (HP:0010514)2.17325839
101Carpal bone hypoplasia (HP:0001498)2.15733507
102Hand muscle atrophy (HP:0009130)2.13556543
103Partial duplication of thumb phalanx (HP:0009944)2.13523435
104Insomnia (HP:0100785)2.11712154
105Disproportionate short-trunk short stature (HP:0003521)2.09387602
106Hypoplastic ilia (HP:0000946)2.09216490
107Thoracolumbar scoliosis (HP:0002944)2.06812913
108Flared metaphyses (HP:0003015)2.05401399
109Fibular hypoplasia (HP:0003038)2.04735889
110Spinal cord compression (HP:0002176)2.04160455
111Ovoid vertebral bodies (HP:0003300)2.03447114
112Ulnar bowing (HP:0003031)2.01684644
113Synostosis involving the elbow (HP:0003938)2.00624706
114Humeroradial synostosis (HP:0003041)2.00624706
115Short ribs (HP:0000773)2.00449360
116Obstructive sleep apnea (HP:0002870)2.00399140
117Thin ribs (HP:0000883)2.00043123
118* Epiphyseal dysplasia (HP:0002656)10.1428007
119Synostosis of carpal bones (HP:0005048)1.99432488
120Hepatoblastoma (HP:0002884)1.98905628
121Neoplasm of the thyroid gland (HP:0100031)1.98128273
122Beaking of vertebral bodies (HP:0004568)1.97442972
123Upper limb amyotrophy (HP:0009129)1.97410126
124Distal upper limb amyotrophy (HP:0007149)1.97410126
125Prenatal maternal abnormality (HP:0002686)1.96317981
126Broad phalanx (HP:0006009)1.96150718
127Overriding aorta (HP:0002623)1.94563183
128Abnormality of the odontoid process (HP:0003310)1.89334753
129Stillbirth (HP:0003826)1.88913977
130Sprengel anomaly (HP:0000912)1.88786537
131Broad long bones (HP:0005622)1.87847263
132Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.87710681
133Long clavicles (HP:0000890)1.87158342
134Broad thumb (HP:0011304)1.86435150
135Partial duplication of the phalanx of hand (HP:0009999)1.86219908
136Renovascular hypertension (HP:0100817)1.85449647
137Abnormality of the lumbar spine (HP:0100712)1.85172488
138Abnormality of the middle phalanges of the hand (HP:0009833)1.84378773
139Broad palm (HP:0001169)1.82415484
140Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.82369835
141Protrusio acetabuli (HP:0003179)1.81844129
142Abnormality of permanent molar morphology (HP:0011071)1.81076137
143Abnormality of the dental root (HP:0006486)1.81076137
144Taurodontia (HP:0000679)1.81076137
145Absent frontal sinuses (HP:0002688)1.79591334
146Abnormality of the humeroradial joint (HP:0100744)1.77446447
147Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.77040727
148Vertebral hypoplasia (HP:0008417)1.77040727
149Biconcave vertebral bodies (HP:0004586)1.75279049
150Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.74913368
151Stridor (HP:0010307)1.74744898
152Umbilical hernia (HP:0001537)1.71858434
153Adrenal hypoplasia (HP:0000835)1.69189820
154Anal stenosis (HP:0002025)1.69103812
155Flat face (HP:0012368)1.68948843
156Increased nuchal translucency (HP:0010880)1.66548334
157Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.66432249
158Abnormality of the dental pulp (HP:0006479)1.66184413
159Hypercholesterolemia (HP:0003124)1.65457660
160Midface retrusion (HP:0011800)1.65231581
161Transposition of the great arteries (HP:0001669)1.65103983
162Abnormal connection of the cardiac segments (HP:0011545)1.65103983
163Abnormal ventriculo-arterial connection (HP:0011563)1.65103983
164Trigonocephaly (HP:0000243)1.64634064
165Bowed forearm bones (HP:0003956)1.63954130
166Bowing of the arm (HP:0006488)1.63954130
167Coronal craniosynostosis (HP:0004440)1.63405719
168Neurofibrillary tangles (HP:0002185)1.63153108
169Macroglossia (HP:0000158)1.62876177
170Asymmetry of the thorax (HP:0001555)1.60684136
171Abnormality of molar (HP:0011077)1.60607101
172Abnormality of molar morphology (HP:0011070)1.60607101
173Hypothermia (HP:0002045)1.60565556
174Hemorrhage of the eye (HP:0011885)1.60517019
175Bifid scrotum (HP:0000048)1.60441054
176Abnormality of the salivary glands (HP:0010286)1.60404408
177Vertebral arch anomaly (HP:0008438)1.60100761
178Premature rupture of membranes (HP:0001788)1.58176074
179Back pain (HP:0003418)1.57378216
180Elfin facies (HP:0004428)1.56478648
181Decreased lacrimation (HP:0000633)1.53073649
182Premature skin wrinkling (HP:0100678)1.52878903
183Germ cell neoplasia (HP:0100728)1.50247072
184Intestinal fistula (HP:0100819)1.50010719
185Breast aplasia (HP:0100783)1.48924804

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR29.68115482
2TRIB35.89538559
3STK394.76040271
4TNIK4.20507260
5FGFR43.42283698
6CDK123.25631425
7AKT33.12699744
8LMTK23.12440248
9EPHB13.01256519
10SMG12.94082676
11OXSR12.63837874
12EEF2K2.62953844
13WNK42.45031284
14LATS22.30639874
15RIPK12.14480742
16SIK12.13464901
17ICK2.11778082
18TYRO32.06783651
19NME21.94619169
20MAP3K101.88669565
21MST41.79434268
22MAP3K31.78025681
23NEK61.75389253
24BCR1.75167941
25PDGFRA1.74060289
26LATS11.60592355
27FGFR21.54719736
28PBK1.50897109
29MET1.49005301
30ERN11.44777584
31WNK11.39070447
32CSNK1A1L1.37720170
33FGFR31.37443965
34UHMK11.34651556
35ROCK21.26579739
36PAK41.25517133
37EPHA21.19255125
38SIK21.17813547
39EPHA41.14736757
40NTRK11.13190780
41MAP3K91.12501606
42PKN11.11441242
43IRAK21.08758089
44PKN21.07996292
45NME11.07002215
46EPHB21.05249602
47PDPK11.04149529
48MTOR1.02396067
49CDK190.99414683
50ROCK10.99328816
51FES0.98119076
52MAPK130.97061495
53CSNK1G10.96473295
54CSNK1G30.95877852
55NTRK30.90186924
56FGFR10.89514286
57STK38L0.89357741
58PAK60.89291248
59TTK0.86687846
60PRKG20.86321729
61PTK60.84202284
62NUAK10.84041217
63PAK30.82593665
64STK240.81823696
65TRPM70.79867236
66DYRK1B0.78573117
67MKNK10.77221317
68CDK70.76627258
69PDGFRB0.76160031
70PLK20.76053397
71FGR0.75242768
72MKNK20.75141197
73IRAK10.73445542
74MAP2K20.70235717
75CSNK1G20.68765004
76LIMK10.68617528
77DYRK1A0.67517946
78STK30.67389827
79ERBB30.66135976
80MAPK70.63029518
81KSR20.62382087
82ARAF0.62167692
83PDK10.59768211
84PRKCQ0.59638612
85CDK40.58267472
86PNCK0.57098748
87ILK0.56015986
88ALK0.55701773
89CAMK1D0.55374988
90PRPF4B0.54872266
91BRSK10.53963685
92GSK3A0.53529481
93CDK11A0.52463768
94CDK150.51339841
95BMX0.51041741
96CDK50.50754130
97NEK20.50385630
98FYN0.49872743
99PRKCE0.49819675
100RPS6KA20.47473212
101PTK20.46865854
102CDK20.46198448
103BRAF0.45748103
104CDC42BPA0.43389083
105CDK180.43177244
106MARK10.42885271
107PIK3CA0.42733991
108NLK0.42515680
109GSK3B0.41629002
110CDK10.41363125
111CSK0.41243036
112DYRK20.39679867
113CSNK1E0.39604986
114MARK20.39250044
115CDK140.38861949
116CASK0.38411270
117CAMK2D0.36772447
118INSR0.36668539
119RPS6KA10.35810743
120MAPK110.35051235
121CLK10.34149739
122TESK10.34109527
123SGK30.33685671
124CSF1R0.32306542
125PHKG20.32001675
126PHKG10.32001675
127PRKCH0.31913781
128ERBB40.31896880
129NTRK20.31034680
130EPHA30.30889924
131PRKCG0.30813591
132PRKCZ0.29910868
133PRKG10.29887765
134PRKDC0.29815143
135MAPK80.28374662
136CAMK2A0.28169063
137RPS6KB10.27980189
138MAPK140.27977817
139ERBB20.27930944
140CAMK2B0.27897489
141CHEK10.27677125
142CAMK1G0.27311072
143PRKD30.26993772
144RPS6KL10.26916542
145RPS6KC10.26916542
146MAPK150.26331715
147AKT20.25961752
148SGK10.25946779
149MAPK100.25564015
150SRC0.24840529
151ABL10.24803602
152RET0.24553452
153SGK2230.24024985
154SGK4940.24024985
155PRKD20.23766872
156BRD40.23196099
157ADRBK10.22250399
158CSNK1A10.22105195
159IRAK40.21600804

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.81632925
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.40933805
3Steroid biosynthesis_Homo sapiens_hsa001004.31578934
4* ECM-receptor interaction_Homo sapiens_hsa045124.06072285
5* Protein digestion and absorption_Homo sapiens_hsa049743.81951798
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.58701167
7Autoimmune thyroid disease_Homo sapiens_hsa053202.54642674
8Axon guidance_Homo sapiens_hsa043602.42044780
9Thyroid cancer_Homo sapiens_hsa052162.26841898
10Ether lipid metabolism_Homo sapiens_hsa005652.22559370
11Tyrosine metabolism_Homo sapiens_hsa003502.17820820
12Basal cell carcinoma_Homo sapiens_hsa052172.07223956
13Sphingolipid metabolism_Homo sapiens_hsa006002.01415695
14Fatty acid elongation_Homo sapiens_hsa000622.00432100
15Sulfur metabolism_Homo sapiens_hsa009201.91790134
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.78212080
17Hedgehog signaling pathway_Homo sapiens_hsa043401.77129137
18* Focal adhesion_Homo sapiens_hsa045101.71682206
19Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.61366659
20Biosynthesis of amino acids_Homo sapiens_hsa012301.59813634
21Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.58250625
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.57373373
23Hippo signaling pathway_Homo sapiens_hsa043901.51695712
24TGF-beta signaling pathway_Homo sapiens_hsa043501.46118304
25Thyroid hormone signaling pathway_Homo sapiens_hsa049191.36551988
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.34339565
27Long-term depression_Homo sapiens_hsa047301.32794731
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.32410560
29Arginine biosynthesis_Homo sapiens_hsa002201.30818989
30Histidine metabolism_Homo sapiens_hsa003401.27465005
31Endometrial cancer_Homo sapiens_hsa052131.27463735
32* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.27047954
33Central carbon metabolism in cancer_Homo sapiens_hsa052301.25268190
34Renal cell carcinoma_Homo sapiens_hsa052111.19340127
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18864329
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17766934
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.15572698
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15213036
39Wnt signaling pathway_Homo sapiens_hsa043101.11748293
40Vitamin B6 metabolism_Homo sapiens_hsa007501.10990921
41Ovarian steroidogenesis_Homo sapiens_hsa049131.09202071
42N-Glycan biosynthesis_Homo sapiens_hsa005101.09041355
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07712941
44Glutamatergic synapse_Homo sapiens_hsa047241.07224966
45Protein export_Homo sapiens_hsa030601.06639957
46Malaria_Homo sapiens_hsa051441.06387719
47Proteoglycans in cancer_Homo sapiens_hsa052051.06387351
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04733237
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98705752
50Long-term potentiation_Homo sapiens_hsa047200.98660379
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94904377
52Serotonergic synapse_Homo sapiens_hsa047260.94398895
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93922496
54Non-small cell lung cancer_Homo sapiens_hsa052230.92395605
55Cholinergic synapse_Homo sapiens_hsa047250.89461275
56Vibrio cholerae infection_Homo sapiens_hsa051100.89315540
57Prion diseases_Homo sapiens_hsa050200.88180197
58Tight junction_Homo sapiens_hsa045300.86929293
59Melanogenesis_Homo sapiens_hsa049160.86830395
60Inositol phosphate metabolism_Homo sapiens_hsa005620.86526389
61Fructose and mannose metabolism_Homo sapiens_hsa000510.86316774
62Carbon metabolism_Homo sapiens_hsa012000.84884572
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83259470
64Fatty acid biosynthesis_Homo sapiens_hsa000610.82824328
65Complement and coagulation cascades_Homo sapiens_hsa046100.82353034
66Chronic myeloid leukemia_Homo sapiens_hsa052200.81214973
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80548393
68Glucagon signaling pathway_Homo sapiens_hsa049220.80180386
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78058197
70Salivary secretion_Homo sapiens_hsa049700.77549830
71Insulin signaling pathway_Homo sapiens_hsa049100.77499526
72Prostate cancer_Homo sapiens_hsa052150.77147576
73mRNA surveillance pathway_Homo sapiens_hsa030150.77014839
74Other glycan degradation_Homo sapiens_hsa005110.76905319
75Colorectal cancer_Homo sapiens_hsa052100.76875012
76Sulfur relay system_Homo sapiens_hsa041220.76369738
77Choline metabolism in cancer_Homo sapiens_hsa052310.75926413
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.74138189
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73582674
80VEGF signaling pathway_Homo sapiens_hsa043700.73261558
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72900979
82ErbB signaling pathway_Homo sapiens_hsa040120.71994256
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.71957593
84Arginine and proline metabolism_Homo sapiens_hsa003300.71139878
85mTOR signaling pathway_Homo sapiens_hsa041500.71085131
86Phenylalanine metabolism_Homo sapiens_hsa003600.70189214
87AMPK signaling pathway_Homo sapiens_hsa041520.70100368
88Galactose metabolism_Homo sapiens_hsa000520.69103100
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68859127
90Dorso-ventral axis formation_Homo sapiens_hsa043200.67382761
91Ras signaling pathway_Homo sapiens_hsa040140.66618719
92Linoleic acid metabolism_Homo sapiens_hsa005910.66268829
93Bile secretion_Homo sapiens_hsa049760.66130522
94Bladder cancer_Homo sapiens_hsa052190.65583645
95Gap junction_Homo sapiens_hsa045400.65014288
96Vitamin digestion and absorption_Homo sapiens_hsa049770.64907250
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64085407
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63108220
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62464795
100Fat digestion and absorption_Homo sapiens_hsa049750.62362532
101Olfactory transduction_Homo sapiens_hsa047400.62138967
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57760287
103Thyroid hormone synthesis_Homo sapiens_hsa049180.56382488
104Butanoate metabolism_Homo sapiens_hsa006500.56192574
105GABAergic synapse_Homo sapiens_hsa047270.55161591
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54898041
107Fatty acid metabolism_Homo sapiens_hsa012120.54307088
108Cocaine addiction_Homo sapiens_hsa050300.54015130
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.53597704
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53535796
111MicroRNAs in cancer_Homo sapiens_hsa052060.53525244
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53444679
113Oxytocin signaling pathway_Homo sapiens_hsa049210.53241522
114Circadian entrainment_Homo sapiens_hsa047130.52834096
115Dopaminergic synapse_Homo sapiens_hsa047280.52552383
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52221568
117Arachidonic acid metabolism_Homo sapiens_hsa005900.51205672
118Small cell lung cancer_Homo sapiens_hsa052220.51086285
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.50789636
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49901047
121Pyruvate metabolism_Homo sapiens_hsa006200.49652846
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49526211
123Dilated cardiomyopathy_Homo sapiens_hsa054140.49389399
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49211742
125Pentose phosphate pathway_Homo sapiens_hsa000300.49174867
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48361728
127PPAR signaling pathway_Homo sapiens_hsa033200.48041974
128Insulin resistance_Homo sapiens_hsa049310.46100344
129GnRH signaling pathway_Homo sapiens_hsa049120.46081705
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45755823
131Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45639165
132Lysine degradation_Homo sapiens_hsa003100.45101811
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.43228061
134Adherens junction_Homo sapiens_hsa045200.42504902
135HIF-1 signaling pathway_Homo sapiens_hsa040660.42117873
136Phagosome_Homo sapiens_hsa041450.41509117
137Endocytosis_Homo sapiens_hsa041440.39946835
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39943026
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38772720
140Notch signaling pathway_Homo sapiens_hsa043300.38709768
141Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38325383
142cAMP signaling pathway_Homo sapiens_hsa040240.37188692
143Gastric acid secretion_Homo sapiens_hsa049710.37106546
144Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36776982
145Amphetamine addiction_Homo sapiens_hsa050310.36680147
146Estrogen signaling pathway_Homo sapiens_hsa049150.34792289
147Oxidative phosphorylation_Homo sapiens_hsa001900.34627732
148Melanoma_Homo sapiens_hsa052180.32075773
149Rheumatoid arthritis_Homo sapiens_hsa053230.31423279
150MAPK signaling pathway_Homo sapiens_hsa040100.30991444
151Renin secretion_Homo sapiens_hsa049240.30775810
152Platelet activation_Homo sapiens_hsa046110.30513311
153Pancreatic secretion_Homo sapiens_hsa049720.30139296
154Pathways in cancer_Homo sapiens_hsa052000.28480215
155Glioma_Homo sapiens_hsa052140.27620462
156Rap1 signaling pathway_Homo sapiens_hsa040150.27393040

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »