COLCA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)8.09608298
2sperm motility (GO:0030317)7.84577140
3cilium or flagellum-dependent cell motility (GO:0001539)7.09613096
4acrosome reaction (GO:0007340)6.43587523
5fusion of sperm to egg plasma membrane (GO:0007342)6.40264418
6cilium movement (GO:0003341)6.02583662
7epithelial cilium movement (GO:0003351)5.97348088
8motile cilium assembly (GO:0044458)5.92544008
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.71033185
10sperm capacitation (GO:0048240)5.70165232
11protein polyglutamylation (GO:0018095)5.35475695
12phosphatidylethanolamine biosynthetic process (GO:0006646)5.16685821
13protein targeting to Golgi (GO:0000042)5.06145517
14regulation of cilium movement (GO:0003352)5.05593934
15cellular ketone body metabolic process (GO:0046950)5.01568111
16axoneme assembly (GO:0035082)4.94280630
17establishment of protein localization to Golgi (GO:0072600)4.84616439
18plasma membrane fusion (GO:0045026)4.74140102
19phosphatidylethanolamine metabolic process (GO:0046337)4.72203396
20retrograde transport, vesicle recycling within Golgi (GO:0000301)4.71029584
21spermatid development (GO:0007286)4.67111282
22response to pheromone (GO:0019236)4.61021492
23microtubule depolymerization (GO:0007019)4.52080660
24centriole assembly (GO:0098534)4.41390436
25ketone body metabolic process (GO:1902224)4.34858948
26chromosome condensation (GO:0030261)4.31123948
27DNA packaging (GO:0006323)4.27325120
28microtubule polymerization or depolymerization (GO:0031109)4.16624347
29single strand break repair (GO:0000012)4.16494497
30spermatogenesis (GO:0007283)4.00833838
31male gamete generation (GO:0048232)3.99738550
32multicellular organism reproduction (GO:0032504)3.99599154
33intestinal cholesterol absorption (GO:0030299)3.98300735
34sperm-egg recognition (GO:0035036)3.91946183
35protein localization to Golgi apparatus (GO:0034067)3.86774148
36sexual reproduction (GO:0019953)3.83121591
37reproduction (GO:0000003)3.80152707
38erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.79218984
39L-phenylalanine catabolic process (GO:0006559)3.79218984
40centriole replication (GO:0007099)3.77724923
41calcium ion-dependent exocytosis (GO:0017156)3.76641772
42microtubule severing (GO:0051013)3.68732677
43gamete generation (GO:0007276)3.68310505
44erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.66437059
45L-phenylalanine metabolic process (GO:0006558)3.66437059
46nephron tubule morphogenesis (GO:0072078)3.61236076
47nephron epithelium morphogenesis (GO:0072088)3.61236076
48phosphatidylcholine biosynthetic process (GO:0006656)3.56584091
49RNA destabilization (GO:0050779)3.53565178
50rRNA methylation (GO:0031167)3.49492403
51regulation of centriole replication (GO:0046599)3.47409405
52peptidyl-glutamic acid modification (GO:0018200)3.43937754
53binding of sperm to zona pellucida (GO:0007339)3.43877414
54glomerular epithelial cell development (GO:0072310)3.41349902
55regulation of cholesterol esterification (GO:0010872)3.40873452
56seminiferous tubule development (GO:0072520)3.36907028
57plasma lipoprotein particle assembly (GO:0034377)3.35810214
58embryonic retina morphogenesis in camera-type eye (GO:0060059)3.34427307
59epithelial cell fate commitment (GO:0072148)3.29205326
60reverse cholesterol transport (GO:0043691)3.26154614
61spermatid nucleus differentiation (GO:0007289)3.21671875
62single fertilization (GO:0007338)3.21657900
63cilium organization (GO:0044782)3.18601291
64low-density lipoprotein particle remodeling (GO:0034374)3.17502395
65cell-cell recognition (GO:0009988)3.17428689
66receptor recycling (GO:0001881)3.16905908
67high-density lipoprotein particle remodeling (GO:0034375)3.15514952
68protein carboxylation (GO:0018214)3.14179364
69peptidyl-glutamic acid carboxylation (GO:0017187)3.14179364
70negative regulation of sodium ion transport (GO:0010766)3.13868580
71ethanol oxidation (GO:0006069)3.13160216
72regulation of fibrinolysis (GO:0051917)3.11614446
73cilium assembly (GO:0042384)3.10983927
74ethanol metabolic process (GO:0006067)3.10575276
75regulation of microtubule-based movement (GO:0060632)3.06563086
76microtubule bundle formation (GO:0001578)3.04059058
77cellular zinc ion homeostasis (GO:0006882)3.01885523
78fertilization (GO:0009566)2.99571503
79regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.96218439
80multicellular organismal reproductive process (GO:0048609)2.95581722
81left/right axis specification (GO:0070986)2.93845805
82alanine transport (GO:0032328)2.90274184
83lung epithelium development (GO:0060428)2.86477319
84plasma lipoprotein particle remodeling (GO:0034369)2.84676970
85protein-lipid complex remodeling (GO:0034368)2.84676970
86macromolecular complex remodeling (GO:0034367)2.84676970
87germ cell development (GO:0007281)2.81250040
88positive regulation of Rab GTPase activity (GO:0032851)2.81211444
89regulation of Rab GTPase activity (GO:0032313)2.81211444
90organic cation transport (GO:0015695)2.80342377
91glycerol ether metabolic process (GO:0006662)2.80013010
92protein-lipid complex assembly (GO:0065005)2.76059247
93rRNA modification (GO:0000154)2.74811529
94negative regulation of inclusion body assembly (GO:0090084)2.72922709
95regulation of bile acid biosynthetic process (GO:0070857)2.72621758
96aromatic amino acid family catabolic process (GO:0009074)2.72436109
97inner ear receptor cell differentiation (GO:0060113)2.72138714
98regulation of transcription involved in cell fate commitment (GO:0060850)2.71012584
99cholesterol efflux (GO:0033344)2.70774020
100ether metabolic process (GO:0018904)2.68323467

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.23154716
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.78462354
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.51417076
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.45655196
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03332717
6FOXA2_19822575_ChIP-Seq_HepG2_Human2.00702800
7CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93417907
8FUS_26573619_Chip-Seq_HEK293_Human1.88127382
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.84754937
10TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79640862
11POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.79640862
12ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.79207344
13CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78485116
14ARNT_22903824_ChIP-Seq_MCF-7_Human1.76644998
15ER_23166858_ChIP-Seq_MCF-7_Human1.71610740
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.63711019
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.62435222
18CBP_20019798_ChIP-Seq_JUKART_Human1.61382451
19IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.61382451
20AR_25329375_ChIP-Seq_VCAP_Human1.60991458
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.59832129
22LXR_22158963_ChIP-Seq_LIVER_Mouse1.58287192
23SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.58067501
24RXR_22158963_ChIP-Seq_LIVER_Mouse1.57535647
25SMAD3_21741376_ChIP-Seq_EPCs_Human1.56020299
26FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.51728729
27EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.51643660
28SMAD4_21741376_ChIP-Seq_EPCs_Human1.51162101
29DROSHA_22980978_ChIP-Seq_HELA_Human1.50766551
30ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50479550
31GATA4_25053715_ChIP-Seq_YYC3_Human1.46387150
32ERA_21632823_ChIP-Seq_H3396_Human1.43539001
33MYC_19829295_ChIP-Seq_ESCs_Human1.41039761
34HNF4A_19822575_ChIP-Seq_HepG2_Human1.40076898
35FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.39583263
36DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.38330213
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37595829
38CEBPB_22108803_ChIP-Seq_LS180_Human1.37201076
39OCT4_20526341_ChIP-Seq_ESCs_Human1.36092549
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35457586
41ZNF274_21170338_ChIP-Seq_K562_Hela1.34961842
42ETV2_25802403_ChIP-Seq_MESCs_Mouse1.33637321
43AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.33331298
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33253124
45PPARA_22158963_ChIP-Seq_LIVER_Mouse1.32627486
46P300_19829295_ChIP-Seq_ESCs_Human1.32047601
47EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31295889
48KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30163210
49SMAD4_21741376_ChIP-Seq_HESCs_Human1.27865769
50EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27698587
51AHR_22903824_ChIP-Seq_MCF-7_Human1.26210151
52SMAD4_21799915_ChIP-Seq_A2780_Human1.26173490
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25687175
54STAT3_23295773_ChIP-Seq_U87_Human1.24966321
55RAC3_21632823_ChIP-Seq_H3396_Human1.22530937
56CDX2_22108803_ChIP-Seq_LS180_Human1.22364149
57TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21747629
58TDRD3_21172665_ChIP-Seq_MCF-7_Human1.21204304
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20440280
60NANOG_20526341_ChIP-Seq_ESCs_Human1.19958373
61GBX2_23144817_ChIP-Seq_PC3_Human1.19932610
62RUNX2_22187159_ChIP-Seq_PCA_Human1.17695152
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17092138
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.17092138
65TAF2_19829295_ChIP-Seq_ESCs_Human1.16953857
66NANOG_19829295_ChIP-Seq_ESCs_Human1.15965660
67SOX2_19829295_ChIP-Seq_ESCs_Human1.15965660
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.15741841
69HOXB7_26014856_ChIP-Seq_BT474_Human1.15127662
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12562305
71FOXA1_25552417_ChIP-Seq_VCAP_Human1.12176995
72VDR_22108803_ChIP-Seq_LS180_Human1.12138616
73CTCF_27219007_Chip-Seq_Bcells_Human1.10924199
74CBX2_22325352_ChIP-Seq_293T-Rex_Human1.10379890
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09822599
76SMC4_20622854_ChIP-Seq_HELA_Human1.09347646
77ERG_20517297_ChIP-Seq_VCAP_Human1.09340665
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.09254504
79TAF15_26573619_Chip-Seq_HEK293_Human1.08564586
80ETV1_20927104_ChIP-Seq_GIST48_Human1.08424260
81TCF4_22108803_ChIP-Seq_LS180_Human1.08123778
82WDR5_24793694_ChIP-Seq_LNCAP_Human1.08091469
83YY1_22570637_ChIP-Seq_MALME-3M_Human1.07947118
84RBPJ_21746931_ChIP-Seq_IB4_Human1.07377050
85HNFA_21074721_ChIP-Seq_CACO-2_Human1.06852653
86TP63_22573176_ChIP-Seq_HFKS_Human1.06249643
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05901807
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05881374
89SMAD3_21741376_ChIP-Seq_ESCs_Human1.05766340
90FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05765770
91PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.05244312
92PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04562664
93GATA6_25053715_ChIP-Seq_YYC3_Human1.03734580
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03466044
95VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02560307
96P300_27268052_Chip-Seq_Bcells_Human1.02257936
97BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02188566
98TCF4_18268006_ChIP-ChIP_LS174T_Human1.02003216
99SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01974209
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01253591

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.83358963
2MP0002139_abnormal_hepatobiliary_system4.74928872
3MP0003878_abnormal_ear_physiology3.08094534
4MP0005377_hearing/vestibular/ear_phenot3.08094534
5MP0005379_endocrine/exocrine_gland_phen2.96051569
6MP0010329_abnormal_lipoprotein_level2.93697816
7MP0003122_maternal_imprinting2.92269929
8MP0005365_abnormal_bile_salt2.89804642
9MP0005670_abnormal_white_adipose2.86128953
10MP0010234_abnormal_vibrissa_follicle2.65647275
11MP0008875_abnormal_xenobiotic_pharmacok2.63878223
12MP0009780_abnormal_chondrocyte_physiolo2.55915948
13MP0001666_abnormal_nutrient_absorption2.44760097
14MP0003698_abnormal_male_reproductive2.41173283
15MP0003195_calcinosis2.32847441
16MP0001929_abnormal_gametogenesis2.10730011
17MP0002132_abnormal_respiratory_system2.06077267
18MP0002909_abnormal_adrenal_gland2.02183707
19MP0004019_abnormal_vitamin_homeostasis2.00562360
20MP0002138_abnormal_hepatobiliary_system1.96816070
21MP0002254_reproductive_system_inflammat1.88611193
22MP0003172_abnormal_lysosome_physiology1.82032274
23MP0005645_abnormal_hypothalamus_physiol1.78700548
24MP0000566_synostosis1.78284213
25MP0003011_delayed_dark_adaptation1.78232099
26MP0001984_abnormal_olfaction1.72658366
27MP0005085_abnormal_gallbladder_physiolo1.68906712
28MP0001944_abnormal_pancreas_morphology1.65221769
29MP0003718_maternal_effect1.64280549
30MP0005332_abnormal_amino_acid1.62095858
31MP0001765_abnormal_ion_homeostasis1.61588075
32MP0005636_abnormal_mineral_homeostasis1.60936169
33MP0003879_abnormal_hair_cell1.53219115
34MP0002876_abnormal_thyroid_physiology1.52175868
35MP0004133_heterotaxia1.46045794
36MP0005310_abnormal_salivary_gland1.45066812
37MP0005220_abnormal_exocrine_pancreas1.42987999
38MP0004043_abnormal_pH_regulation1.42803560
39MP0002693_abnormal_pancreas_physiology1.40703304
40MP0005551_abnormal_eye_electrophysiolog1.40046442
41MP0005084_abnormal_gallbladder_morpholo1.37435738
42MP0001485_abnormal_pinna_reflex1.35612264
43MP0003123_paternal_imprinting1.35348536
44MP0002161_abnormal_fertility/fecundity1.34217823
45MP0001756_abnormal_urination1.27290501
46MP0001348_abnormal_lacrimal_gland1.26905723
47MP0005360_urolithiasis1.25968425
48MP0002118_abnormal_lipid_homeostasis1.24960125
49MP0005408_hypopigmentation1.22884117
50MP0003252_abnormal_bile_duct1.21875988
51MP0002163_abnormal_gland_morphology1.20548605
52MP0000678_abnormal_parathyroid_gland1.18820144
53MP0002078_abnormal_glucose_homeostasis1.18683014
54MP0002837_dystrophic_cardiac_calcinosis1.16199409
55MP0003868_abnormal_feces_composition1.13314310
56MP0005395_other_phenotype1.10937252
57MP0005646_abnormal_pituitary_gland1.10604066
58MP0003646_muscle_fatigue1.06165095
59MP0003953_abnormal_hormone_level1.00104185
60MP0003787_abnormal_imprinting0.97923666
61MP0009643_abnormal_urine_homeostasis0.97298500
62MP0000639_abnormal_adrenal_gland0.96510903
63MP0003121_genomic_imprinting0.95430198
64MP0009046_muscle_twitch0.95328984
65MP0002229_neurodegeneration0.93419298
66MP0002210_abnormal_sex_determination0.91458808
67MP0004270_analgesia0.91056556
68MP0000653_abnormal_sex_gland0.89372185
69MP0009115_abnormal_fat_cell0.88102725
70MP0002557_abnormal_social/conspecific_i0.88065274
71MP0000609_abnormal_liver_physiology0.87394619
72MP0001486_abnormal_startle_reflex0.86606954
73MP0005253_abnormal_eye_physiology0.86075616
74MP0005451_abnormal_body_composition0.85464658
75MP0001145_abnormal_male_reproductive0.85402280
76MP0005083_abnormal_biliary_tract0.84227147
77MP0004264_abnormal_extraembryonic_tissu0.84157230
78MP0005448_abnormal_energy_balance0.83261698
79MP0008877_abnormal_DNA_methylation0.82116655
80MP0002168_other_aberrant_phenotype0.76951199
81MP0000003_abnormal_adipose_tissue0.76528284
82MP0001764_abnormal_homeostasis0.74551730
83MP0001501_abnormal_sleep_pattern0.74250891
84MP0001529_abnormal_vocalization0.74219624
85MP0001270_distended_abdomen0.73554828
86MP0002938_white_spotting0.71295014
87MP0003283_abnormal_digestive_organ0.70986689
88MP0000631_abnormal_neuroendocrine_gland0.67835956
89MP0001963_abnormal_hearing_physiology0.66711671
90MP0002653_abnormal_ependyma_morphology0.66383609
91MP0005248_abnormal_Harderian_gland0.66133952
92MP0004085_abnormal_heartbeat0.66110712
93MP0006072_abnormal_retinal_apoptosis0.66022911
94MP0002928_abnormal_bile_duct0.65794588
95MP0000516_abnormal_urinary_system0.64666659
96MP0005367_renal/urinary_system_phenotyp0.64666659
97MP0002734_abnormal_mechanical_nocicepti0.62715802
98MP0000026_abnormal_inner_ear0.62348136
99MP0009642_abnormal_blood_homeostasis0.61727194
100MP0002160_abnormal_reproductive_system0.61095429

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.42159161
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.37842608
3Absent/shortened dynein arms (HP:0200106)6.37842608
4Abnormal respiratory epithelium morphology (HP:0012253)5.87680280
5Abnormal respiratory motile cilium morphology (HP:0005938)5.87680280
6Abnormal respiratory motile cilium physiology (HP:0012261)5.85274964
7Abnormal ciliary motility (HP:0012262)5.84569273
8Rhinitis (HP:0012384)5.05095939
9Severe visual impairment (HP:0001141)4.36299988
10Chronic bronchitis (HP:0004469)3.97587123
11Nasal polyposis (HP:0100582)3.86461799
12Chronic hepatic failure (HP:0100626)3.76882230
13Tubulointerstitial nephritis (HP:0001970)3.70279946
14Bronchiectasis (HP:0002110)3.65211787
15Facial shape deformation (HP:0011334)3.33707930
16Potter facies (HP:0002009)3.33707930
17Abnormality of aromatic amino acid family metabolism (HP:0004338)3.32201386
18Pancreatic fibrosis (HP:0100732)3.21586918
19Hyperkalemia (HP:0002153)3.08872590
20Prolonged partial thromboplastin time (HP:0003645)3.04945060
21Infertility (HP:0000789)2.93643280
22Vascular calcification (HP:0004934)2.92337316
23Abnormality of the nasal mucosa (HP:0000433)2.91047128
24True hermaphroditism (HP:0010459)2.90573948
25Bony spicule pigmentary retinopathy (HP:0007737)2.89828432
26Nephronophthisis (HP:0000090)2.78357399
27Cystic liver disease (HP:0006706)2.77120972
28Deep venous thrombosis (HP:0002625)2.75564094
29Pancreatic cysts (HP:0001737)2.71610909
30Male infertility (HP:0003251)2.69808786
31Congenital malformation of the right heart (HP:0011723)2.67626587
32Double outlet right ventricle (HP:0001719)2.67626587
33Hypobetalipoproteinemia (HP:0003563)2.66990625
34Hypolipoproteinemia (HP:0010981)2.66806142
35Hypoalphalipoproteinemia (HP:0003233)2.59119929
36Occipital encephalocele (HP:0002085)2.55475897
37Cone-rod dystrophy (HP:0000548)2.42463143
38Abnormality of renal excretion (HP:0011036)2.42236915
39Abnormality of the renal medulla (HP:0100957)2.40974983
40Cardiovascular calcification (HP:0011915)2.38006262
41Menstrual irregularities (HP:0000858)2.32071674
42Abnormal rod and cone electroretinograms (HP:0008323)2.30958677
43Attenuation of retinal blood vessels (HP:0007843)2.30529084
44Abnormality of macular pigmentation (HP:0008002)2.28617404
45Hypophosphatemic rickets (HP:0004912)2.24109929
46Late onset (HP:0003584)2.19153106
47Tubular atrophy (HP:0000092)2.18985864
48Abnormality of the renal cortex (HP:0011035)2.18665641
49Stage 5 chronic kidney disease (HP:0003774)2.16960917
50Amelogenesis imperfecta (HP:0000705)2.16802107
51Asymmetric septal hypertrophy (HP:0001670)2.16663645
52Molar tooth sign on MRI (HP:0002419)2.16205721
53Abnormality of midbrain morphology (HP:0002418)2.16205721
54Abnormal urine output (HP:0012590)2.15904710
55Fat malabsorption (HP:0002630)2.15312260
56Abnormality of urine glucose concentration (HP:0011016)2.13681559
57Glycosuria (HP:0003076)2.13681559
58Tubulointerstitial abnormality (HP:0001969)2.13573990
59Ketoacidosis (HP:0001993)2.10863586
60Joint hemorrhage (HP:0005261)2.03243228
61Abnormality of vitamin B metabolism (HP:0004340)2.02411643
62Abnormality of chloride homeostasis (HP:0011422)2.01425041
63Abnormality of vitamin metabolism (HP:0100508)2.00503314
64Polydipsia (HP:0001959)1.99037906
65Abnormal drinking behavior (HP:0030082)1.99037906
66Azoospermia (HP:0000027)1.98847450
67Unilateral renal agenesis (HP:0000122)1.98219299
68Insulin-resistant diabetes mellitus (HP:0000831)1.97993563
69Male pseudohermaphroditism (HP:0000037)1.97803134
70Abnormality of dental color (HP:0011073)1.97555217
71Osteomalacia (HP:0002749)1.96555685
72Progressive sensorineural hearing impairment (HP:0000408)1.96135056
73Hypoglycemic coma (HP:0001325)1.95288879
74Hyperactive renin-angiotensin system (HP:0000841)1.93037264
75Pancreatic islet-cell hyperplasia (HP:0004510)1.91591902
76Intestinal atresia (HP:0011100)1.90780222
77Hyperthyroidism (HP:0000836)1.85631414
78Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.82109080
79Pigmentary retinal degeneration (HP:0001146)1.82026406
80Abnormal biliary tract physiology (HP:0012439)1.81303038
81Bile duct proliferation (HP:0001408)1.81303038
82Recurrent sinusitis (HP:0011108)1.81151214
83Epiphyseal dysplasia (HP:0002656)1.80467459
84Hyperphosphatemia (HP:0002905)1.78446547
85Steatorrhea (HP:0002570)1.74140415
86Recurrent otitis media (HP:0000403)1.73954058
87Widely patent fontanelles and sutures (HP:0004492)1.73048867
88Hyperuricemia (HP:0002149)1.72947554
89Increased purine levels (HP:0004368)1.72947554
90Postaxial foot polydactyly (HP:0001830)1.72048029
91Subcapsular cataract (HP:0000523)1.71681642
92Abnormality of potassium homeostasis (HP:0011042)1.70251141
93Hyponatremia (HP:0002902)1.70197453
94Progressive hearing impairment (HP:0001730)1.70132426
95Large for gestational age (HP:0001520)1.69325397
96Chronic sinusitis (HP:0011109)1.68832235
97Abnormal sex determination (HP:0012244)1.68073516
98Sex reversal (HP:0012245)1.68073516
99Ketosis (HP:0001946)1.67771865
100Bronchitis (HP:0012387)1.66920683

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK45.65281759
2FRK4.02686627
3MAP4K23.36654557
4INSRR3.34350462
5PNCK3.01672287
6MAPK152.88686880
7WNK42.72283797
8TESK12.69126437
9PLK22.62905437
10AKT32.32582762
11FGFR32.31310321
12CAMK1G2.21151406
13MST42.18465573
14FGFR22.12977316
15MST1R2.10990676
16PRKD32.09589421
17DDR21.93136104
18STK241.87772564
19FGFR41.86423488
20STK381.82136032
21BRD41.81116714
22STK391.73175499
23STK38L1.72657163
24EPHA21.61594453
25GRK11.47859358
26PDPK11.33183456
27MAP3K41.30501437
28PTK2B1.29617475
29WNK11.25942440
30PRKAA21.21787055
31PDK11.21539163
32LMTK21.08977063
33BRSK21.07195618
34PHKG20.97466273
35PHKG10.97466273
36BRAF0.94502498
37NTRK30.92246962
38ADRBK20.91800541
39MET0.87238764
40ICK0.84693920
41ACVR1B0.84681905
42FER0.84613775
43EEF2K0.82764267
44BRSK10.80688725
45CDK120.79923136
46EIF2AK10.79253921
47DYRK1B0.78424982
48NME10.78339675
49SGK4940.77308454
50SGK2230.77308454
51PRKG20.72802373
52BMPR1B0.72446944
53PRKCE0.70972166
54FGFR10.70358757
55WNK30.68697027
56NLK0.68261814
57CDK70.66771661
58SGK10.66377595
59CAMK1D0.66178906
60NEK60.65336019
61PRKCI0.65302948
62MAP3K20.64743772
63ARAF0.63056888
64OXSR10.61549289
65DAPK20.61427268
66MAPK110.61358977
67PRKG10.60271383
68SGK20.58165832
69MAP2K60.56559132
70TRPM70.53873352
71MAP3K90.52393151
72PRKCG0.52043007
73MAPKAPK30.50323692
74PRKAA10.49837962
75TAF10.49372008
76TYRO30.47825585
77SGK30.45454538
78CASK0.44069766
79MAP2K20.39084396
80ERBB20.38219573
81CAMK2D0.37950028
82MAP3K100.37163457
83CSNK1E0.35300430
84TNK20.34300938
85CSNK1A10.32046966
86PRKCZ0.29099396
87GSK3B0.28455958
88PIM20.27885631
89IRAK20.27712840
90PKN20.27615925
91MTOR0.27080453
92STK30.26200784
93PRKACA0.25620377
94PAK30.25541915
95UHMK10.24531143
96MKNK20.23966914
97CAMK10.22847892
98ROCK10.22259642
99SIK20.21506370
100CDK10.20957930

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.35981955
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.14058693
3Fatty acid biosynthesis_Homo sapiens_hsa000613.37170904
4Vitamin B6 metabolism_Homo sapiens_hsa007502.45211302
5Butanoate metabolism_Homo sapiens_hsa006502.41757595
6Fat digestion and absorption_Homo sapiens_hsa049752.38015506
7Fatty acid degradation_Homo sapiens_hsa000712.24723688
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.24279099
9Phenylalanine metabolism_Homo sapiens_hsa003602.24049234
10Complement and coagulation cascades_Homo sapiens_hsa046102.05612620
11Arginine biosynthesis_Homo sapiens_hsa002202.02299744
12Histidine metabolism_Homo sapiens_hsa003402.01430503
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.81803427
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.76310990
15Fatty acid metabolism_Homo sapiens_hsa012121.74521694
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.74180944
17ABC transporters_Homo sapiens_hsa020101.72748665
18Chemical carcinogenesis_Homo sapiens_hsa052041.70584328
19Arginine and proline metabolism_Homo sapiens_hsa003301.68608181
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68476653
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.60289436
22Tyrosine metabolism_Homo sapiens_hsa003501.59526598
23Vitamin digestion and absorption_Homo sapiens_hsa049771.59242526
24Retinol metabolism_Homo sapiens_hsa008301.49134858
25beta-Alanine metabolism_Homo sapiens_hsa004101.48672700
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.48576049
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.48443318
28PPAR signaling pathway_Homo sapiens_hsa033201.45339740
29Propanoate metabolism_Homo sapiens_hsa006401.44460428
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.35867690
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34646778
32Steroid biosynthesis_Homo sapiens_hsa001001.34295064
33Sphingolipid metabolism_Homo sapiens_hsa006001.26095449
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.26071781
35Peroxisome_Homo sapiens_hsa041461.24726740
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.23521205
37Tryptophan metabolism_Homo sapiens_hsa003801.21817549
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18345972
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.16782797
40Starch and sucrose metabolism_Homo sapiens_hsa005001.15742273
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.14291308
42Glutathione metabolism_Homo sapiens_hsa004801.10437953
43Bile secretion_Homo sapiens_hsa049761.09231205
44Folate biosynthesis_Homo sapiens_hsa007901.08972781
45Glycerolipid metabolism_Homo sapiens_hsa005611.07925366
46Insulin secretion_Homo sapiens_hsa049111.07919070
47Sulfur metabolism_Homo sapiens_hsa009201.05002498
48Nitrogen metabolism_Homo sapiens_hsa009100.99154651
49Mineral absorption_Homo sapiens_hsa049780.98781879
50Linoleic acid metabolism_Homo sapiens_hsa005910.97285206
51Thyroid hormone synthesis_Homo sapiens_hsa049180.94449219
52N-Glycan biosynthesis_Homo sapiens_hsa005100.92293453
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90809020
54Ether lipid metabolism_Homo sapiens_hsa005650.86544859
55Circadian rhythm_Homo sapiens_hsa047100.86213379
56Renin-angiotensin system_Homo sapiens_hsa046140.85548203
57Pancreatic secretion_Homo sapiens_hsa049720.81147863
58Olfactory transduction_Homo sapiens_hsa047400.80744577
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80409615
60Selenocompound metabolism_Homo sapiens_hsa004500.77835203
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76968073
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74964689
63Other glycan degradation_Homo sapiens_hsa005110.74740623
64Glucagon signaling pathway_Homo sapiens_hsa049220.72099841
65Metabolic pathways_Homo sapiens_hsa011000.70992874
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68630648
67Caffeine metabolism_Homo sapiens_hsa002320.68122037
68Protein digestion and absorption_Homo sapiens_hsa049740.65310701
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64023649
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60255914
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60107519
72Taste transduction_Homo sapiens_hsa047420.59536449
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56597737
74Salivary secretion_Homo sapiens_hsa049700.53446635
75Type I diabetes mellitus_Homo sapiens_hsa049400.51813767
76Tight junction_Homo sapiens_hsa045300.51586967
77Arachidonic acid metabolism_Homo sapiens_hsa005900.49957309
78Type II diabetes mellitus_Homo sapiens_hsa049300.48939786
79Phototransduction_Homo sapiens_hsa047440.47856975
80Renin secretion_Homo sapiens_hsa049240.47817652
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47179247
82Fructose and mannose metabolism_Homo sapiens_hsa000510.44743744
83Serotonergic synapse_Homo sapiens_hsa047260.44600535
84Protein export_Homo sapiens_hsa030600.43299020
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.43050195
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41615149
87Huntingtons disease_Homo sapiens_hsa050160.40255471
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39256260
89Lysine degradation_Homo sapiens_hsa003100.39085031
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.38354000
91Insulin resistance_Homo sapiens_hsa049310.37603935
92Inositol phosphate metabolism_Homo sapiens_hsa005620.33702669
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31827476
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.31827363
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30786128
96Pyruvate metabolism_Homo sapiens_hsa006200.27716778
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25357971
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24556919
99Cardiac muscle contraction_Homo sapiens_hsa042600.22458811
100Collecting duct acid secretion_Homo sapiens_hsa049660.20647582

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »