COLEC11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.44990535
2L-phenylalanine catabolic process (GO:0006559)7.44990535
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.15473750
4L-phenylalanine metabolic process (GO:0006558)7.15473750
5aromatic amino acid family catabolic process (GO:0009074)6.63875942
6exogenous drug catabolic process (GO:0042738)6.42122323
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.39303329
8indole-containing compound catabolic process (GO:0042436)5.94255485
9indolalkylamine catabolic process (GO:0046218)5.94255485
10tryptophan catabolic process (GO:0006569)5.94255485
11kynurenine metabolic process (GO:0070189)5.90530954
12glyoxylate metabolic process (GO:0046487)5.84167383
13bile acid biosynthetic process (GO:0006699)5.80881525
14tryptophan metabolic process (GO:0006568)5.60241901
15high-density lipoprotein particle remodeling (GO:0034375)5.57483031
16alpha-linolenic acid metabolic process (GO:0036109)5.54173184
17negative regulation of fibrinolysis (GO:0051918)5.54051197
18urea metabolic process (GO:0019627)5.48345840
19urea cycle (GO:0000050)5.48345840
20omega-hydroxylase P450 pathway (GO:0097267)5.43015516
21regulation of fibrinolysis (GO:0051917)5.34268315
22complement activation, alternative pathway (GO:0006957)5.32095984
23peptidyl-glutamic acid carboxylation (GO:0017187)5.31836886
24protein carboxylation (GO:0018214)5.31836886
25epoxygenase P450 pathway (GO:0019373)5.30972501
26regulation of protein activation cascade (GO:2000257)5.27660318
27sulfur amino acid catabolic process (GO:0000098)5.23520196
28cysteine metabolic process (GO:0006534)5.19157441
29nitrogen cycle metabolic process (GO:0071941)5.04146072
30serine family amino acid catabolic process (GO:0009071)5.03087152
31regulation of triglyceride catabolic process (GO:0010896)4.96755307
32bile acid metabolic process (GO:0008206)4.94495376
33regulation of complement activation (GO:0030449)4.92798111
34regulation of cholesterol esterification (GO:0010872)4.89824336
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.84768063
36reverse cholesterol transport (GO:0043691)4.84399294
37oxidative demethylation (GO:0070989)4.83576744
38aromatic amino acid family metabolic process (GO:0009072)4.82621907
39protein-lipid complex remodeling (GO:0034368)4.76981684
40macromolecular complex remodeling (GO:0034367)4.76981684
41plasma lipoprotein particle remodeling (GO:0034369)4.76981684
42lysine catabolic process (GO:0006554)4.72385225
43lysine metabolic process (GO:0006553)4.72385225
44tyrosine metabolic process (GO:0006570)4.72224115
45homocysteine metabolic process (GO:0050667)4.67298941
46cellular ketone body metabolic process (GO:0046950)4.63239705
47amino-acid betaine metabolic process (GO:0006577)4.61756104
48triglyceride homeostasis (GO:0070328)4.61656822
49acylglycerol homeostasis (GO:0055090)4.61656822
50alpha-amino acid catabolic process (GO:1901606)4.61580497
51phospholipid efflux (GO:0033700)4.55112351
52negative regulation of cholesterol transport (GO:0032375)4.49533829
53negative regulation of sterol transport (GO:0032372)4.49533829
54plasma lipoprotein particle clearance (GO:0034381)4.41681219
55coenzyme catabolic process (GO:0009109)4.33624552
56glycine metabolic process (GO:0006544)4.31272403
57bile acid and bile salt transport (GO:0015721)4.23935707
58cellular amino acid catabolic process (GO:0009063)4.23905425
59glutamate metabolic process (GO:0006536)4.22846435
60drug metabolic process (GO:0017144)4.22669608
61imidazole-containing compound metabolic process (GO:0052803)4.20338032
62indolalkylamine metabolic process (GO:0006586)4.19852006
63cholesterol efflux (GO:0033344)4.17285038
64cellular biogenic amine catabolic process (GO:0042402)4.14898725
65amine catabolic process (GO:0009310)4.14898725
66dicarboxylic acid biosynthetic process (GO:0043650)4.09281864
67ethanol oxidation (GO:0006069)4.08588676
68cellular glucuronidation (GO:0052695)4.08473657
69benzene-containing compound metabolic process (GO:0042537)4.05113002
70serine family amino acid metabolic process (GO:0009069)4.03990688
71ketone body metabolic process (GO:1902224)4.01508523
72arginine metabolic process (GO:0006525)4.01018380
73arginine catabolic process (GO:0006527)3.99614221
74plasma lipoprotein particle assembly (GO:0034377)3.98790359
75cellular modified amino acid catabolic process (GO:0042219)3.97753623
76fibrinolysis (GO:0042730)3.95413528
77aldehyde catabolic process (GO:0046185)3.95338415
78low-density lipoprotein particle remodeling (GO:0034374)3.91851855
79S-adenosylmethionine metabolic process (GO:0046500)3.88559765
80negative regulation of lipase activity (GO:0060192)3.85940062
81ethanol metabolic process (GO:0006067)3.85332824
82drug catabolic process (GO:0042737)3.84217612
83serine family amino acid biosynthetic process (GO:0009070)3.82376017
84blood coagulation, intrinsic pathway (GO:0007597)3.81945267
85piRNA metabolic process (GO:0034587)3.81150685
86acetyl-CoA metabolic process (GO:0006084)3.79504250
87positive regulation of lipid catabolic process (GO:0050996)3.79259788
88short-chain fatty acid metabolic process (GO:0046459)3.77773160
89organic acid catabolic process (GO:0016054)3.77733509
90carboxylic acid catabolic process (GO:0046395)3.77733509
91positive regulation of lipoprotein lipase activity (GO:0051006)3.77680287
92positive regulation of triglyceride lipase activity (GO:0061365)3.77680287
93phospholipid homeostasis (GO:0055091)3.76124372
94cofactor catabolic process (GO:0051187)3.75763147
95cholesterol homeostasis (GO:0042632)3.73106740
96very-low-density lipoprotein particle assembly (GO:0034379)3.69232881
97complement activation (GO:0006956)3.67618869
98uronic acid metabolic process (GO:0006063)3.66780014
99glucuronate metabolic process (GO:0019585)3.66780014
100regulation of bile acid biosynthetic process (GO:0070857)3.66534985
101sterol homeostasis (GO:0055092)3.66508209
102protein activation cascade (GO:0072376)3.66272718
103complement activation, classical pathway (GO:0006958)3.66192478
104aspartate family amino acid catabolic process (GO:0009068)3.62537047
1052-oxoglutarate metabolic process (GO:0006103)3.61837826
106plasma lipoprotein particle organization (GO:0071827)3.61140890
107monocarboxylic acid catabolic process (GO:0072329)3.58019063
108protein-lipid complex assembly (GO:0065005)3.56560271
109positive regulation of fatty acid beta-oxidation (GO:0032000)3.54622176
110regulation of meiosis I (GO:0060631)3.18554906
111negative regulation of protein activation cascade (GO:2000258)3.18008671
112phenylpropanoid metabolic process (GO:0009698)3.13123881
113regulation of glucokinase activity (GO:0033131)3.11444810
114regulation of hexokinase activity (GO:1903299)3.11444810
115alkaloid metabolic process (GO:0009820)3.09575893
116regulation of plasminogen activation (GO:0010755)3.08641644
117opsonization (GO:0008228)3.04882285
118behavioral response to nicotine (GO:0035095)3.04778144
119negative regulation of hemostasis (GO:1900047)3.03608429
120negative regulation of blood coagulation (GO:0030195)3.03608429
121amino acid salvage (GO:0043102)2.97914666
122L-methionine salvage (GO:0071267)2.97914666
123L-methionine biosynthetic process (GO:0071265)2.97914666
124water-soluble vitamin biosynthetic process (GO:0042364)2.89152277
125DNA methylation involved in gamete generation (GO:0043046)2.86214406
126regulation of humoral immune response (GO:0002920)2.81021421
127negative regulation of coagulation (GO:0050819)2.80708548
128dopamine transport (GO:0015872)2.80486880
129atrial cardiac muscle cell action potential (GO:0086014)2.77818999
130cytolysis (GO:0019835)2.73977550
131DNA deamination (GO:0045006)2.70576659
132peptidyl-glutamic acid modification (GO:0018200)2.68156053
133heme transport (GO:0015886)2.67889043
134negative regulation of complement activation (GO:0045916)2.67531683
135negative regulation of astrocyte differentiation (GO:0048712)2.67067687
136kidney morphogenesis (GO:0060993)2.66797801

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.24207673
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.07498156
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.77070056
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.41264955
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.29153566
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.24300975
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.94541508
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.98025673
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.78324225
10VDR_22108803_ChIP-Seq_LS180_Human3.13493843
11ZNF274_21170338_ChIP-Seq_K562_Hela3.06197383
12GBX2_23144817_ChIP-Seq_PC3_Human2.73145462
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.55120626
14EZH2_22144423_ChIP-Seq_EOC_Human2.32688271
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28854843
16IGF1R_20145208_ChIP-Seq_DFB_Human2.28432033
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.25841014
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.24576600
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.11873987
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.04009528
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7991822
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.97113289
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87688539
24P300_19829295_ChIP-Seq_ESCs_Human1.82973458
25FUS_26573619_Chip-Seq_HEK293_Human1.80877141
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79563562
27CLOCK_20551151_ChIP-Seq_293T_Human1.75798828
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68643040
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67656560
30GATA1_22025678_ChIP-Seq_K562_Human1.66810428
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66236132
32TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63241429
33POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.63241429
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62221850
35ER_23166858_ChIP-Seq_MCF-7_Human1.62007553
36* FOXA2_19822575_ChIP-Seq_HepG2_Human1.61081021
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.56232582
38HTT_18923047_ChIP-ChIP_STHdh_Human1.55434536
39* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55097697
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51720621
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.51017104
42SMAD4_21799915_ChIP-Seq_A2780_Human1.47352041
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47057685
44EWS_26573619_Chip-Seq_HEK293_Human1.46058263
45* TCF4_23295773_ChIP-Seq_U87_Human1.45535861
46* AR_25329375_ChIP-Seq_VCAP_Human1.44892642
47KLF5_20875108_ChIP-Seq_MESCs_Mouse1.44095545
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43976787
49STAT3_23295773_ChIP-Seq_U87_Human1.41815276
50* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41692780
51* CBP_20019798_ChIP-Seq_JUKART_Human1.41692780
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39504301
53* HNF4A_19822575_ChIP-Seq_HepG2_Human1.36133819
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33297192
55TCF4_22108803_ChIP-Seq_LS180_Human1.31232903
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30356826
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.29794815
58TP53_16413492_ChIP-PET_HCT116_Human1.27614843
59* SMAD4_21741376_ChIP-Seq_EPCs_Human1.27289466
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.26704664
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25188014
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.22863204
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22588017
64IRF1_19129219_ChIP-ChIP_H3396_Human1.21605813
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21555736
66RNF2_27304074_Chip-Seq_NSC_Mouse1.20979629
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20380066
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20318839
69RUNX2_22187159_ChIP-Seq_PCA_Human1.20201145
70GATA3_21878914_ChIP-Seq_MCF-7_Human1.20153396
71SOX2_19829295_ChIP-Seq_ESCs_Human1.20144382
72NANOG_19829295_ChIP-Seq_ESCs_Human1.20144382
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.20119530
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18198583
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17362276
76STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17243644
77STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14983622
78RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14864399
79CRX_20693478_ChIP-Seq_RETINA_Mouse1.14168499
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13544809
81FLI1_27457419_Chip-Seq_LIVER_Mouse1.13120008
82* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13057751
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12406553
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12369523
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.12308930
86FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12267942
87TP53_22573176_ChIP-Seq_HFKS_Human1.11841926
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11679576
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11185619
90BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10806365
91MYC_19829295_ChIP-Seq_ESCs_Human1.07243443
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06448509
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06418574
94FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05803332
95FOXA1_25329375_ChIP-Seq_VCAP_Human1.05803332
96HOXB7_26014856_ChIP-Seq_BT474_Human1.03495083
97RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03288799
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03018299
99CDX2_22108803_ChIP-Seq_LS180_Human1.02916767
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01821498
101CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99037618
102PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98927348
103NANOG_18555785_Chip-Seq_ESCs_Mouse0.98236576
104ZNF263_19887448_ChIP-Seq_K562_Human0.97047406
105ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96559632
106TBL1_22424771_ChIP-Seq_293T_Human0.96402755
107EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.96152893
108SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96058378
109* NCOR_22424771_ChIP-Seq_293T_Human0.95649744
110ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95105718
111IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94445087
112ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92738046
113SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92194572
114AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90885320
115TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90056297
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83275590
117SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79915736
118SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77084185
119GATA4_25053715_ChIP-Seq_YYC3_Human0.76709538
120CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73116181
121ESR2_21235772_ChIP-Seq_MCF-7_Human0.72832796
122KAP1_22055183_ChIP-Seq_ESCs_Mouse0.70684107
123SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.68452059
124RARA_24833708_ChIP-Seq_LIVER_Mouse0.68421743
125NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.67012675
126AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66582599
127NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.65776857
128NRF2_20460467_ChIP-Seq_MEFs_Mouse0.65776857
129Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.63015691
130RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62460715
131IRF8_22096565_ChIP-ChIP_GC-B_Human0.61786296
132NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.60135952
133RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.59762166
134RARB_24833708_ChIP-Seq_LIVER_Mouse0.59164536
135GATA1_19941826_ChIP-Seq_K562_Human0.57823650
136STAT3_1855785_ChIP-Seq_MESCs_Mouse0.57154731
137CEBPB_22108803_ChIP-Seq_LS180_Human0.56744339
138FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.56516972
139PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.56225300
140PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.55998006
141* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.55762644
142LXR_22292898_ChIP-Seq_THP-1_Human0.54874777
143EGR1_19032775_ChIP-ChIP_M12_Human0.54755070
144ESR1_20079471_ChIP-ChIP_T-47D_Human0.54609589
145NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.53203306
146FOXA1_25552417_ChIP-Seq_VCAP_Human0.52876285
147GATA1_19941827_ChIP-Seq_MEL_Mouse0.51021442
148TBX20_22080862_ChIP-Seq_HEART_Mouse0.50777061
149TBX20_22328084_ChIP-Seq_HEART_Mouse0.50777061
150AR_20517297_ChIP-Seq_VCAP_Human0.50761167
151* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.50122451
152GATA2_19941826_ChIP-Seq_K562_Human0.50018518
153FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49601432
154MYC_19915707_ChIP-ChIP_AK7_Human0.48733761
155PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.48452822
156CBP_21632823_ChIP-Seq_H3396_Human0.48347643
157P53_21459846_ChIP-Seq_SAOS-2_Human0.48263326
158ESET_19884257_ChIP-Seq_ESCs_Mouse0.47742977
159ESR1_21235772_ChIP-Seq_MCF-7_Human0.46932154
160FOXO3_23340844_ChIP-Seq_DLD1_Human0.46785193
161PPAR_26484153_Chip-Seq_NCI-H1993_Human0.45601316
162BCAT_22108803_ChIP-Seq_LS180_Human0.45220815
163STAT1_17558387_ChIP-Seq_HELA_Human0.44269941
164ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.42751436
165PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42735059
166SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42515562
167TAF2_19829295_ChIP-Seq_ESCs_Human0.42474453
168CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.42170408
169MYC_27129775_Chip-Seq_CORNEA_Mouse0.41155494
170TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.40689751
171FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.40111316
172STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38818443
173E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.38722113
174CDX2_20551321_ChIP-Seq_CACO-2_Human0.38259411
175TAF15_26573619_Chip-Seq_HEK293_Human0.37354210
176ERG_21242973_ChIP-ChIP_JURKAT_Human0.36545995
177SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.36450975
178GATA6_25053715_ChIP-Seq_YYC3_Human0.36428490
179P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.35251969
180GATA3_24758297_ChIP-Seq_MCF-7_Human0.35137460
181OCT4_20526341_ChIP-Seq_ESCs_Human0.35029255

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.17737265
2MP0005360_urolithiasis7.38324030
3MP0005085_abnormal_gallbladder_physiolo6.39587422
4MP0005365_abnormal_bile_salt6.05524276
5MP0008875_abnormal_xenobiotic_pharmacok5.06065790
6MP0003806_abnormal_nucleotide_metabolis4.22698704
7MP0003252_abnormal_bile_duct3.85997157
8MP0010329_abnormal_lipoprotein_level3.57096013
9MP0009840_abnormal_foam_cell3.32018992
10MP0005083_abnormal_biliary_tract3.03211957
11MP0003195_calcinosis2.84398054
12MP0005332_abnormal_amino_acid2.74555023
13MP0001666_abnormal_nutrient_absorption2.48243582
14MP0008877_abnormal_DNA_methylation2.41131593
15MP0003191_abnormal_cellular_cholesterol2.27500595
16MP0000609_abnormal_liver_physiology2.14617028
17MP0002118_abnormal_lipid_homeostasis2.11490267
18MP0005551_abnormal_eye_electrophysiolog2.09831480
19MP0004019_abnormal_vitamin_homeostasis2.01337685
20MP0002138_abnormal_hepatobiliary_system1.91850603
21MP0003868_abnormal_feces_composition1.90556070
22MP0005319_abnormal_enzyme/_coenzyme1.86652927
23MP0006292_abnormal_olfactory_placode1.86550539
24MP0005451_abnormal_body_composition1.61030463
25MP0001764_abnormal_homeostasis1.60226573
26MP0009697_abnormal_copulation1.56969669
27MP0005584_abnormal_enzyme/coenzyme_acti1.56262978
28MP0003283_abnormal_digestive_organ1.53876043
29MP0002102_abnormal_ear_morphology1.52348313
30MP0005646_abnormal_pituitary_gland1.44871129
31MP0003656_abnormal_erythrocyte_physiolo1.41400330
32MP0000372_irregular_coat_pigmentation1.39564682
33MP0005379_endocrine/exocrine_gland_phen1.33871486
34MP0002735_abnormal_chemical_nociception1.33698213
35MP0002638_abnormal_pupillary_reflex1.33537196
36MP0008775_abnormal_heart_ventricle1.29256800
37MP0003186_abnormal_redox_activity1.28798082
38MP0004043_abnormal_pH_regulation1.27945457
39MP0003011_delayed_dark_adaptation1.27423806
40MP0003787_abnormal_imprinting1.26856190
41MP0009643_abnormal_urine_homeostasis1.24355887
42MP0004215_abnormal_myocardial_fiber1.22884394
43MP0003705_abnormal_hypodermis_morpholog1.22697491
44MP0002909_abnormal_adrenal_gland1.21713482
45MP0010368_abnormal_lymphatic_system1.18759159
46MP0000598_abnormal_liver_morphology1.17487924
47MP0002282_abnormal_trachea_morphology1.15513712
48MP0002837_dystrophic_cardiac_calcinosis1.14797267
49MP0004084_abnormal_cardiac_muscle1.13990983
50MP0005647_abnormal_sex_gland1.09790440
51MP0002751_abnormal_autonomic_nervous1.09479596
52MP0003136_yellow_coat_color1.08727105
53MP0005670_abnormal_white_adipose1.08704973
54MP0002938_white_spotting1.08387504
55MP0009745_abnormal_behavioral_response1.07064289
56MP0002160_abnormal_reproductive_system1.06836402
57MP0001968_abnormal_touch/_nociception1.05228061
58MP0004133_heterotaxia1.03305025
59MP0006036_abnormal_mitochondrial_physio1.03245387
60MP0009763_increased_sensitivity_to1.01817783
61MP0000604_amyloidosis1.01370502
62MP0003122_maternal_imprinting1.00976719
63MP0009764_decreased_sensitivity_to1.00940269
64MP0004130_abnormal_muscle_cell0.99897667
65MP0006276_abnormal_autonomic_nervous0.99791271
66MP0005253_abnormal_eye_physiology0.97817269
67MP0002163_abnormal_gland_morphology0.95868978
68MP0004085_abnormal_heartbeat0.95382249
69MP0003137_abnormal_impulse_conducting0.93806590
70MP0001485_abnormal_pinna_reflex0.93401210
71MP0005410_abnormal_fertilization0.91541747
72MP0001502_abnormal_circadian_rhythm0.91305130
73MP0005636_abnormal_mineral_homeostasis0.90201095
74MP0003950_abnormal_plasma_membrane0.87965732
75MP0009642_abnormal_blood_homeostasis0.86786444
76MP0002736_abnormal_nociception_after0.85800676
77MP0008469_abnormal_protein_level0.85467295
78MP0000631_abnormal_neuroendocrine_gland0.84423129
79MP0002254_reproductive_system_inflammat0.81749425
80MP0005645_abnormal_hypothalamus_physiol0.81618783
81MP0002078_abnormal_glucose_homeostasis0.80851318
82MP0002272_abnormal_nervous_system0.80339473
83MP0005376_homeostasis/metabolism_phenot0.80215260
84MP0005408_hypopigmentation0.77853643
85MP0001984_abnormal_olfaction0.77751304
86MP0004924_abnormal_behavior0.77727543
87MP0005386_behavior/neurological_phenoty0.77727543
88MP0005195_abnormal_posterior_eye0.77485852
89MP0003943_abnormal_hepatobiliary_system0.77395086
90MP0001929_abnormal_gametogenesis0.76468037
91MP0002234_abnormal_pharynx_morphology0.75201117
92MP0003698_abnormal_male_reproductive0.74934623
93MP0002971_abnormal_brown_adipose0.74409364
94MP0008995_early_reproductive_senescence0.73667777
95MP0005266_abnormal_metabolism0.72963162
96MP0005084_abnormal_gallbladder_morpholo0.72615948
97MP0002210_abnormal_sex_determination0.72166238
98MP0000653_abnormal_sex_gland0.71668440
99MP0003119_abnormal_digestive_system0.71502334
100MP0009765_abnormal_xenobiotic_induced0.71082471
101MP0003567_abnormal_fetal_cardiomyocyte0.70196815
102MP0004142_abnormal_muscle_tone0.69355053
103MP0005334_abnormal_fat_pad0.68881998
104MP0005187_abnormal_penis_morphology0.68742773
105MP0005535_abnormal_body_temperature0.68516405
106MP0005389_reproductive_system_phenotype0.68349916
107MP0005220_abnormal_exocrine_pancreas0.67001957
108MP0003690_abnormal_glial_cell0.66693912
109MP0003880_abnormal_central_pattern0.66346342
110MP0006035_abnormal_mitochondrial_morpho0.64674247
111MP0009046_muscle_twitch0.64441414
112MP0001661_extended_life_span0.64391121
113MP0002876_abnormal_thyroid_physiology0.61074093
114MP0009053_abnormal_anal_canal0.61013307
115MP0000639_abnormal_adrenal_gland0.60473815
116MP0003329_amyloid_beta_deposits0.59805671
117MP0001756_abnormal_urination0.59023688
118MP0005330_cardiomyopathy0.57225497
119MP0005666_abnormal_adipose_tissue0.55819597
120MP0002822_catalepsy0.54895145
121MP0005448_abnormal_energy_balance0.54482559
122MP0008874_decreased_physiological_sensi0.47291662
123MP0000230_abnormal_systemic_arterial0.45220362
124MP0005464_abnormal_platelet_physiology0.44558137
125MP0005395_other_phenotype0.43966778
126MP0003638_abnormal_response/metabolism_0.42867605
127MP0002136_abnormal_kidney_physiology0.42501359
128MP0003724_increased_susceptibility_to0.42313834
129MP0009384_cardiac_valve_regurgitation0.42263089
130MP0008873_increased_physiological_sensi0.41391810
131MP0003718_maternal_effect0.40691809
132MP0003953_abnormal_hormone_level0.40158171
133MP0002269_muscular_atrophy0.38662402
134MP0000249_abnormal_blood_vessel0.37878832
135MP0002928_abnormal_bile_duct0.36969516
136MP0003075_altered_response_to0.36240464
137MP0009672_abnormal_birth_weight0.35687112
138MP0005167_abnormal_blood-brain_barrier0.35352206
139MP0009115_abnormal_fat_cell0.33466604
140MP0008872_abnormal_physiological_respon0.33085788
141MP0005166_decreased_susceptibility_to0.32734595
142MP0005248_abnormal_Harderian_gland0.32711325
143MP0004036_abnormal_muscle_relaxation0.32283281
144MP0004782_abnormal_surfactant_physiolog0.31884413
145MP0003646_muscle_fatigue0.31541419
146MP0002970_abnormal_white_adipose0.31479497
147MP0005385_cardiovascular_system_phenoty0.31198461
148MP0001544_abnormal_cardiovascular_syste0.31198461
149MP0006138_congestive_heart_failure0.31164485
150MP0001243_abnormal_dermal_layer0.29399827
151MP0004883_abnormal_blood_vessel0.28817282
152MP0000579_abnormal_nail_morphology0.28004733
153MP0003436_decreased_susceptibility_to0.27298564
154MP0002168_other_aberrant_phenotype0.26731432
155MP0004147_increased_porphyrin_level0.25823972
156MP0005595_abnormal_vascular_smooth0.24723054

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.29068166
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.17196989
3Intrahepatic cholestasis (HP:0001406)7.05963360
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.36721472
5Prolonged partial thromboplastin time (HP:0003645)6.35547320
6Hypobetalipoproteinemia (HP:0003563)6.26028618
7Xanthomatosis (HP:0000991)6.21548324
8Hyperlipoproteinemia (HP:0010980)5.61880195
9Complement deficiency (HP:0004431)5.19179359
10Hypolipoproteinemia (HP:0010981)4.79465756
11Joint hemorrhage (HP:0005261)4.64903353
12Hyperammonemia (HP:0001987)4.63645455
13Epidermoid cyst (HP:0200040)4.42523198
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.39582981
15Ketosis (HP:0001946)4.37662253
16Hypoalphalipoproteinemia (HP:0003233)4.31246403
17Abnormality of the common coagulation pathway (HP:0010990)4.30762430
18Hyperglycinemia (HP:0002154)4.28413414
19Abnormality of methionine metabolism (HP:0010901)4.23894028
20Type II lissencephaly (HP:0007260)4.09913688
21Abnormality of sulfur amino acid metabolism (HP:0004339)4.08727699
22Hypoglycemic coma (HP:0001325)4.07309894
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.05610350
24Hyperglycinuria (HP:0003108)3.95535319
25Birth length less than 3rd percentile (HP:0003561)3.93031209
26Abnormality of glutamine family amino acid metabolism (HP:0010902)3.92069882
27Abnormality of glycine metabolism (HP:0010895)3.89723979
28Abnormality of serine family amino acid metabolism (HP:0010894)3.89723979
29Fat malabsorption (HP:0002630)3.85901543
30Abnormality of complement system (HP:0005339)3.76484500
31Abnormality of the intrinsic pathway (HP:0010989)3.68492330
32Abnormality of pyrimidine metabolism (HP:0004353)3.60987541
33Abnormality of fatty-acid metabolism (HP:0004359)3.56113823
34Hypercholesterolemia (HP:0003124)3.51175351
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.49529301
36Hyperventilation (HP:0002883)3.41946254
37Conjugated hyperbilirubinemia (HP:0002908)3.38153732
38Hyperbilirubinemia (HP:0002904)3.36332451
39Ketoacidosis (HP:0001993)3.26097768
40Abnormality of midbrain morphology (HP:0002418)3.21892862
41Molar tooth sign on MRI (HP:0002419)3.21892862
42Pancreatic cysts (HP:0001737)3.21278938
43Congenital stationary night blindness (HP:0007642)3.17255390
44Nephronophthisis (HP:0000090)3.13864938
45Delayed CNS myelination (HP:0002188)3.08720254
46Abnormality of serum amino acid levels (HP:0003112)3.07491357
47Hepatocellular carcinoma (HP:0001402)2.99728665
48Fair hair (HP:0002286)2.98403357
49Spontaneous abortion (HP:0005268)2.96727692
50Pancreatic fibrosis (HP:0100732)2.95357029
51Retinal atrophy (HP:0001105)2.92692380
52Skin nodule (HP:0200036)2.92325702
53Abnormality of nucleobase metabolism (HP:0010932)2.92258430
54True hermaphroditism (HP:0010459)2.91955450
55Cerebellar dysplasia (HP:0007033)2.90540096
56Steatorrhea (HP:0002570)2.89733324
57Metabolic acidosis (HP:0001942)2.88951582
58Myocardial infarction (HP:0001658)2.86370958
59Dicarboxylic aciduria (HP:0003215)2.83094108
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.83094108
61Hypochromic microcytic anemia (HP:0004840)2.77806327
62Abnormality of the renal medulla (HP:0100957)2.75486778
63Breast hypoplasia (HP:0003187)2.73977120
64Abnormality of the renal cortex (HP:0011035)2.73779874
65Cerebral edema (HP:0002181)2.73345009
66Lethargy (HP:0001254)2.71312277
67Abnormal gallbladder morphology (HP:0012437)2.60110473
68Systemic lupus erythematosus (HP:0002725)2.59581554
69Abnormality of purine metabolism (HP:0004352)2.57893874
70Cholelithiasis (HP:0001081)2.55892179
71Chronic hepatic failure (HP:0100626)2.52704009
72Acanthocytosis (HP:0001927)2.50968302
73Glomerulonephritis (HP:0000099)2.49037826
74Mitral stenosis (HP:0001718)2.48783287
75Vascular calcification (HP:0004934)2.48254551
76Hypoglycemic seizures (HP:0002173)2.46732654
77Cholecystitis (HP:0001082)2.40953749
78Abnormal gallbladder physiology (HP:0012438)2.40953749
79Gout (HP:0001997)2.40295261
80Abolished electroretinogram (ERG) (HP:0000550)2.40129401
81Retinal dysplasia (HP:0007973)2.35956227
82Spastic diplegia (HP:0001264)2.33751881
83Abnormal rod and cone electroretinograms (HP:0008323)2.29116682
84Neonatal onset (HP:0003623)2.28230487
85Cystic liver disease (HP:0006706)2.27607873
86Amyloidosis (HP:0011034)2.26400627
87Abnormality of the pons (HP:0007361)2.25466566
88Abnormality of the vitreous humor (HP:0004327)2.24137527
89Cardiovascular calcification (HP:0011915)2.23829967
90Irritability (HP:0000737)2.23632913
91Esophageal varix (HP:0002040)2.22453062
92Attenuation of retinal blood vessels (HP:0007843)2.19680815
93Hypothermia (HP:0002045)2.18154676
94Vomiting (HP:0002013)2.18097502
95Hyperinsulinemic hypoglycemia (HP:0000825)2.17982526
96Male pseudohermaphroditism (HP:0000037)2.17971360
97Hypoplasia of the pons (HP:0012110)2.17659719
98Generalized aminoaciduria (HP:0002909)2.17512781
99Decreased electroretinogram (ERG) amplitude (HP:0000654)2.16430758
100Late onset (HP:0003584)2.15244243
101Malnutrition (HP:0004395)2.14831364
102Gingival bleeding (HP:0000225)2.10817703
103Thrombophlebitis (HP:0004418)2.08874068
104Pancreatitis (HP:0001733)2.08664744
105Poikilocytosis (HP:0004447)2.08557716
106Congenital sensorineural hearing impairment (HP:0008527)2.08530642
107Tubular atrophy (HP:0000092)2.07841175
108Recurrent gram-negative bacterial infections (HP:0005420)2.07775469
109Abnormal biliary tract physiology (HP:0012439)2.07467058
110Bile duct proliferation (HP:0001408)2.07467058
111Brushfield spots (HP:0001088)2.06299593
112Medial flaring of the eyebrow (HP:0010747)2.05532309
113Sensorimotor neuropathy (HP:0007141)2.04668857
114Enlarged kidneys (HP:0000105)2.03495834
115Abnormality of the gallbladder (HP:0005264)2.03427457
116Sclerocornea (HP:0000647)2.02690998
117Hemorrhage of the eye (HP:0011885)2.00887243
118Keratoconus (HP:0000563)2.00477329
119Increased corneal curvature (HP:0100692)2.00477329
120Menorrhagia (HP:0000132)2.00359254
121Abnormal cartilage morphology (HP:0002763)1.99281067
122Intestinal atresia (HP:0011100)1.98273525
123Scotoma (HP:0000575)1.97812646
124Pendular nystagmus (HP:0012043)1.96974604
125Lissencephaly (HP:0001339)1.95909585
126Microretrognathia (HP:0000308)1.91964074
127Abnormality of iron homeostasis (HP:0011031)1.91661024
128Generalized hypopigmentation of hair (HP:0011358)1.91195589
129Renal cortical cysts (HP:0000803)1.90766352
130Abnormality of urine glucose concentration (HP:0011016)1.90690424
131Glycosuria (HP:0003076)1.90690424
132Opisthotonus (HP:0002179)1.89061949
133Abnormal urine output (HP:0012590)1.88833292
134Hyperglycemia (HP:0003074)1.88571379
135Polyuria (HP:0000103)1.86617117
136Decreased central vision (HP:0007663)1.86550151
137Abnormality of transition element cation homeostasis (HP:0011030)1.85234346
138Disproportionate short-trunk short stature (HP:0003521)1.83173227
139Rickets (HP:0002748)1.81672291
140Acute encephalopathy (HP:0006846)1.81510848
141Reticulocytosis (HP:0001923)1.81300126
142Polydipsia (HP:0001959)1.80565730
143Abnormal drinking behavior (HP:0030082)1.80565730
144Elevated hepatic transaminases (HP:0002910)1.79294756
145Proximal tubulopathy (HP:0000114)1.77602839
146Hypophosphatemic rickets (HP:0004912)1.77555440
147Abnormality of proline metabolism (HP:0010907)1.77277660
148Hydroxyprolinuria (HP:0003080)1.77277660
149Nephritis (HP:0000123)1.77103547
150Acute hepatic failure (HP:0006554)1.76978097
151Chorioretinal atrophy (HP:0000533)1.75630947
152Aplasia/Hypoplasia of the tongue (HP:0010295)1.75529222
153Myoglobinuria (HP:0002913)1.74100342
154Prominent supraorbital ridges (HP:0000336)1.73839240
155Congenital hepatic fibrosis (HP:0002612)1.72460735
156Severe visual impairment (HP:0001141)1.69956795
157Aplasia/Hypoplasia of the spleen (HP:0010451)1.64338408
158Dandy-Walker malformation (HP:0001305)1.64315451
159Acute necrotizing encephalopathy (HP:0006965)1.63039448
160Mesangial abnormality (HP:0001966)1.62221200
161Aplasia/Hypoplasia of the tibia (HP:0005772)1.61755043

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.15177953
2ACVR1B4.51247343
3FGFR44.24047268
4SIK14.22367168
5ERN13.96126813
6BMPR1B3.76602481
7CASK3.68582729
8PKN23.06394661
9INSRR2.67838962
10ERBB42.58177147
11TAOK32.46079289
12TLK12.43680469
13TRIB32.26927241
14ZAK2.25010572
15MAP4K22.20771145
16MAP2K42.12832244
17FLT32.10030547
18PNCK2.08592431
19ADRBK22.02510156
20WNK31.99158638
21NUAK11.92285707
22MST1R1.80646582
23MKNK21.78219435
24MAPK111.77245609
25TGFBR11.72618765
26NEK91.67217269
27KDR1.62836869
28PINK11.61507734
29STK391.56940988
30MAPK131.52665791
31TYK21.51876356
32DAPK21.49818781
33TIE11.49437805
34PIK3CG1.48530865
35LATS11.46723247
36WNK41.40305772
37PTK61.39663783
38MAP3K41.39604126
39MAP3K71.35133511
40ABL21.35090159
41MARK31.33999939
42OXSR11.29566367
43MUSK1.27417284
44BRSK21.22867482
45NTRK31.21386215
46PRKAA21.20266726
47JAK21.15837768
48TNIK1.10668222
49PLK41.10394214
50MAP2K31.09373664
51RIPK11.04909989
52ADRBK11.03186453
53WEE11.01766940
54TBK11.01721856
55PRKCE1.00608827
56STK38L0.99933108
57MYLK0.99686839
58MAPK40.99006428
59FGFR20.97771900
60MARK10.97327200
61MAP3K110.96632674
62MAPK150.96504165
63MAPK120.93439217
64CAMK1G0.92806439
65PDK40.90918870
66PDK30.90918870
67JAK10.90575095
68IRAK10.90504645
69NTRK20.90283668
70OBSCN0.89286438
71ERBB20.87964898
72NME10.87078219
73MAP3K30.86831606
74MET0.86153171
75PRKCZ0.84671098
76PLK20.81425481
77EPHB10.80749765
78PRKACG0.80442821
79STK110.79269148
80GRK60.79258470
81CAMK2G0.78737186
82MAP3K100.77709957
83PRKAA10.76606495
84TTN0.76184898
85PIK3CA0.75696659
86VRK10.74604614
87FRK0.72601327
88CAMK1D0.72168390
89TGFBR20.71798401
90KIT0.70220742
91PHKG20.69741186
92PHKG10.69741186
93FER0.68750993
94PRKG10.68555418
95CAMK40.68420997
96PRKCI0.68332561
97CAMK10.68086637
98CAMKK10.65530826
99GSK3A0.65044216
100CDK60.65003567
101MAP3K50.64986827
102MAPK70.64582380
103STK30.63203696
104EPHA30.63045332
105SGK30.62354055
106AKT30.61475849
107PRKACA0.61247781
108CSK0.61226310
109CAMK2A0.58053040
110MAP2K70.54802120
111PDPK10.54247760
112MAP3K140.53978376
113PTK20.53173904
114MST40.52530269
115PKN10.52494591
116PRKCQ0.50946220
117MAP2K60.49803307
118PAK30.49387778
119EPHB20.49059668
120NLK0.48532143
121RET0.48309593
122MKNK10.48133289
123EIF2AK30.48048566
124CSNK1A10.47988283
125MAP2K20.47812210
126MAP3K60.47390030
127CDK30.46956084
128PDGFRA0.46722775
129FGFR30.46720799
130TRIM280.45925193
131CAMKK20.45039626
132DYRK1B0.45004204
133MAP2K10.44835207
134IRAK30.42575877
135SGK20.42428366
136CDK40.42189750
137PLK30.41237951
138ICK0.40323187
139IKBKE0.39420282
140TNK20.38796430
141PRKD10.38538186
142TEC0.37426504
143PIM10.36981584
144ROCK10.36638682
145MTOR0.36401012
146IGF1R0.36386417
147DYRK20.36379221
148CSNK1D0.36089273
149CSF1R0.36031415
150CSNK1G10.36012314
151TXK0.35465178
152PRKG20.35159553
153PTK2B0.34658725
154PDK20.33920361
155EPHA40.31651845
156NEK10.31567795
157PDK10.30969307
158SGK4940.30319348
159SGK2230.30319348
160EGFR0.29247177
161GRK10.28742072
162MAP3K10.28188220
163LATS20.27937022
164PRKCG0.27582038
165PRKACB0.26874389

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.39596154
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.51555127
3Nitrogen metabolism_Homo sapiens_hsa009103.45656647
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.24362355
5Arginine biosynthesis_Homo sapiens_hsa002203.05824329
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.72327329
7Complement and coagulation cascades_Homo sapiens_hsa046102.71843532
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.67957872
9Tryptophan metabolism_Homo sapiens_hsa003802.66887849
10Fatty acid degradation_Homo sapiens_hsa000712.63534782
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50226674
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.49104240
13Butanoate metabolism_Homo sapiens_hsa006502.18252178
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.17042924
15Propanoate metabolism_Homo sapiens_hsa006402.10306015
16Peroxisome_Homo sapiens_hsa041462.08472031
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.07116257
18PPAR signaling pathway_Homo sapiens_hsa033201.92698368
19Fatty acid metabolism_Homo sapiens_hsa012121.92615484
20Chemical carcinogenesis_Homo sapiens_hsa052041.88526114
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85591880
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.83310729
23Histidine metabolism_Homo sapiens_hsa003401.83176942
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.73626326
25Staphylococcus aureus infection_Homo sapiens_hsa051501.72070252
26beta-Alanine metabolism_Homo sapiens_hsa004101.71278374
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.70440556
28Caffeine metabolism_Homo sapiens_hsa002321.68146387
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66994042
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.65805231
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64246728
32Retinol metabolism_Homo sapiens_hsa008301.61781774
33Phenylalanine metabolism_Homo sapiens_hsa003601.58419432
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53137278
35Selenocompound metabolism_Homo sapiens_hsa004501.49686385
36Pyruvate metabolism_Homo sapiens_hsa006201.46122218
37Bile secretion_Homo sapiens_hsa049761.45210406
38Fatty acid elongation_Homo sapiens_hsa000621.44188016
39Tyrosine metabolism_Homo sapiens_hsa003501.43359753
40Sulfur metabolism_Homo sapiens_hsa009201.31147524
41Starch and sucrose metabolism_Homo sapiens_hsa005001.31063619
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.30560428
43Carbon metabolism_Homo sapiens_hsa012001.27223298
44Biosynthesis of amino acids_Homo sapiens_hsa012301.23681363
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.20231248
46ABC transporters_Homo sapiens_hsa020101.14784058
47Fat digestion and absorption_Homo sapiens_hsa049751.14713934
48Folate biosynthesis_Homo sapiens_hsa007901.14412035
49Steroid biosynthesis_Homo sapiens_hsa001001.08795547
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03341754
51Arginine and proline metabolism_Homo sapiens_hsa003301.03303496
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02277808
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.00593557
54Phototransduction_Homo sapiens_hsa047440.94533891
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.91611724
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88328162
57Sulfur relay system_Homo sapiens_hsa041220.87833569
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86695738
59Vitamin B6 metabolism_Homo sapiens_hsa007500.86556754
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86407256
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85742376
62Lysine degradation_Homo sapiens_hsa003100.82572179
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81806998
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80963499
65Protein export_Homo sapiens_hsa030600.79847329
66Vitamin digestion and absorption_Homo sapiens_hsa049770.78609699
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77489132
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67345094
69One carbon pool by folate_Homo sapiens_hsa006700.66068534
70Glycerolipid metabolism_Homo sapiens_hsa005610.65041834
71Glutathione metabolism_Homo sapiens_hsa004800.64188744
72Mineral absorption_Homo sapiens_hsa049780.63505690
73Pentose phosphate pathway_Homo sapiens_hsa000300.57927403
74Fanconi anemia pathway_Homo sapiens_hsa034600.56592933
75Fatty acid biosynthesis_Homo sapiens_hsa000610.53061592
76Homologous recombination_Homo sapiens_hsa034400.47480790
77Metabolic pathways_Homo sapiens_hsa011000.47464398
78Serotonergic synapse_Homo sapiens_hsa047260.47449152
79Ether lipid metabolism_Homo sapiens_hsa005650.46217506
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44980261
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40165039
82Basal transcription factors_Homo sapiens_hsa030220.35304128
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33517382
84Cardiac muscle contraction_Homo sapiens_hsa042600.33363302
85Prion diseases_Homo sapiens_hsa050200.33094834
86Huntingtons disease_Homo sapiens_hsa050160.30729788
87Nicotine addiction_Homo sapiens_hsa050330.30544424
88RNA polymerase_Homo sapiens_hsa030200.30517241
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30477731
90Galactose metabolism_Homo sapiens_hsa000520.30357139
91Insulin resistance_Homo sapiens_hsa049310.28622791
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27619392
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.26432654
94Fructose and mannose metabolism_Homo sapiens_hsa000510.24182985
95Insulin secretion_Homo sapiens_hsa049110.24045203
96Linoleic acid metabolism_Homo sapiens_hsa005910.23910043
97Olfactory transduction_Homo sapiens_hsa047400.23126291
98Morphine addiction_Homo sapiens_hsa050320.22978391
99Collecting duct acid secretion_Homo sapiens_hsa049660.22100715
100Dorso-ventral axis formation_Homo sapiens_hsa043200.19958847
101Calcium signaling pathway_Homo sapiens_hsa040200.19249671
102GABAergic synapse_Homo sapiens_hsa047270.18573286
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.18213121
104Glucagon signaling pathway_Homo sapiens_hsa049220.16118337
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15820806
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.15231808
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.12393008
108AMPK signaling pathway_Homo sapiens_hsa041520.04908630
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2263480
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2252790
111Hepatitis C_Homo sapiens_hsa05160-0.2230651
112Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2201265
113Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2155067
114Amoebiasis_Homo sapiens_hsa05146-0.2103687
115Alzheimers disease_Homo sapiens_hsa05010-0.2023352
116Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1920834
117African trypanosomiasis_Homo sapiens_hsa05143-0.1897755
118Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1748955
119Parkinsons disease_Homo sapiens_hsa05012-0.1683700
120Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1672475
121Oxidative phosphorylation_Homo sapiens_hsa00190-0.1563173
122Regulation of autophagy_Homo sapiens_hsa04140-0.1535005
123Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1361538
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1125717
125Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1041251
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0829526
127Insulin signaling pathway_Homo sapiens_hsa04910-0.0507457
128Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0353231

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