COLEC12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor, a cell surface glycoprotein that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein by vascular endothelial cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)5.75380774
2protein heterotrimerization (GO:0070208)5.20522366
3chondrocyte proliferation (GO:0035988)4.96224699
4negative regulation of axon extension involved in axon guidance (GO:0048843)4.74659686
5neuron projection extension involved in neuron projection guidance (GO:1902284)4.71776427
6axon extension involved in axon guidance (GO:0048846)4.71776427
7positive regulation of gastrulation (GO:2000543)4.50291320
8collagen metabolic process (GO:0032963)4.37270418
9collagen catabolic process (GO:0030574)4.33879506
10negative regulation of axon guidance (GO:1902668)4.29438765
11endodermal cell differentiation (GO:0035987)4.19215163
12regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.13165151
13multicellular organismal macromolecule metabolic process (GO:0044259)4.12581423
14sequestering of extracellular ligand from receptor (GO:0035581)4.05444409
15multicellular organismal catabolic process (GO:0044243)3.99579204
16cell adhesion mediated by integrin (GO:0033627)3.96177686
17multicellular organismal metabolic process (GO:0044236)3.93349755
18bone trabecula formation (GO:0060346)3.89302100
19positive regulation of cardiac muscle cell differentiation (GO:2000727)3.82094397
20apoptotic cell clearance (GO:0043277)3.81965635
21protein carboxylation (GO:0018214)3.80510534
22peptidyl-glutamic acid carboxylation (GO:0017187)3.80510534
23regulation of mesoderm development (GO:2000380)3.79467913
24keratan sulfate catabolic process (GO:0042340)3.77035542
25regulation of axon extension involved in axon guidance (GO:0048841)3.75956581
26mesenchymal-epithelial cell signaling (GO:0060638)3.73418706
27tooth mineralization (GO:0034505)3.64330064
28extracellular negative regulation of signal transduction (GO:1900116)3.61852554
29extracellular regulation of signal transduction (GO:1900115)3.61852554
30regulation of axon guidance (GO:1902667)3.58308115
31positive regulation of fatty acid beta-oxidation (GO:0032000)3.57554166
32vascular endothelial growth factor signaling pathway (GO:0038084)3.55519051
33extracellular matrix disassembly (GO:0022617)3.51756744
34kidney mesenchyme development (GO:0072074)3.50286327
35retina vasculature morphogenesis in camera-type eye (GO:0061299)3.47575068
36adhesion of symbiont to host cell (GO:0044650)3.46032260
37virion attachment to host cell (GO:0019062)3.46032260
38regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.38430560
39skin morphogenesis (GO:0043589)3.36962203
40basement membrane organization (GO:0071711)3.36688396
41regulation of complement activation (GO:0030449)3.36616907
42regulation of protein activation cascade (GO:2000257)3.34862976
43positive regulation of extracellular matrix organization (GO:1903055)3.30770027
44endocardial cushion development (GO:0003197)3.30028860
45negative regulation of fibrinolysis (GO:0051918)3.26029200
46regulation of cardiac muscle cell differentiation (GO:2000725)3.22608210
47regulation of cardioblast differentiation (GO:0051890)3.21901636
48positive regulation of embryonic development (GO:0040019)3.21783212
49metanephric mesenchyme development (GO:0072075)3.21104907
50negative chemotaxis (GO:0050919)3.20439190
51epoxygenase P450 pathway (GO:0019373)3.19321728
52regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.11998507
53pericardium development (GO:0060039)3.10111967
54lateral sprouting from an epithelium (GO:0060601)3.09019610
55wound healing, spreading of epidermal cells (GO:0035313)3.06814745
56glomerular basement membrane development (GO:0032836)3.06302311
57midgut development (GO:0007494)3.04514738
58regulation of fibrinolysis (GO:0051917)3.04130949
59complement activation, alternative pathway (GO:0006957)3.01453535
60lymphangiogenesis (GO:0001946)3.01291289
61regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.98006229
62positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.97333059
63positive regulation of p38MAPK cascade (GO:1900745)2.97053860
64lung-associated mesenchyme development (GO:0060484)2.96554263
65organ induction (GO:0001759)2.96238031
66regulation of organ formation (GO:0003156)2.94270669
67positive regulation of fatty acid oxidation (GO:0046321)2.93053013
68endothelial cell morphogenesis (GO:0001886)2.91798333
69middle ear morphogenesis (GO:0042474)2.90577148
70cellular response to vitamin (GO:0071295)2.89879359
71regulation of gastrulation (GO:0010470)2.89158686
72negative regulation of chondrocyte differentiation (GO:0032331)2.88684797
73regulation of non-canonical Wnt signaling pathway (GO:2000050)2.88469183
74positive regulation of cardiac muscle tissue development (GO:0055025)2.87795392
75peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.86837341
76extracellular matrix assembly (GO:0085029)2.86461130
77axis elongation (GO:0003401)2.83041912
78dermatan sulfate biosynthetic process (GO:0030208)2.83020962
79regulation of extracellular matrix disassembly (GO:0010715)2.82167006
80fibrinolysis (GO:0042730)2.80731333
81negative regulation of BMP signaling pathway (GO:0030514)2.80250378
82substrate-dependent cell migration (GO:0006929)2.78685063
83craniofacial suture morphogenesis (GO:0097094)2.78496689
84regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.77775793
85regulation of fatty acid beta-oxidation (GO:0031998)2.76511588
86cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.75198259
87artery development (GO:0060840)2.74574944
88kidney morphogenesis (GO:0060993)2.74270257
89head development (GO:0060322)2.72835469
90insulin-like growth factor receptor signaling pathway (GO:0048009)2.72702136
91cell migration involved in sprouting angiogenesis (GO:0002042)2.72545082
92G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.72368305
93low-density lipoprotein particle clearance (GO:0034383)2.71644433
94adhesion of symbiont to host (GO:0044406)2.71380490
95negative regulation of embryonic development (GO:0045992)2.70913204
96negative regulation of fatty acid transport (GO:2000192)2.70454466
97blood vessel maturation (GO:0001955)2.70417546
98extracellular matrix organization (GO:0030198)2.69913776
99extracellular structure organization (GO:0043062)2.68765847
100hematopoietic stem cell proliferation (GO:0071425)2.66405524
101lung vasculature development (GO:0060426)2.66312467
102positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.65839937
103iron ion import (GO:0097286)2.65090717
104homocysteine metabolic process (GO:0050667)2.63909144
105plasma lipoprotein particle clearance (GO:0034381)2.62538896
106positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.62332295
107positive regulation of endothelial cell apoptotic process (GO:2000353)2.62239575
108chondrocyte development (GO:0002063)2.60657106
109regulation of chemokine-mediated signaling pathway (GO:0070099)2.59614803
110regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.59391420
111cornea development in camera-type eye (GO:0061303)2.59264441
112peptidyl-proline hydroxylation (GO:0019511)2.58883068
113endothelial cell proliferation (GO:0001935)2.58521236
114negative regulation of protein activation cascade (GO:2000258)2.58305107
115negative regulation of leukocyte chemotaxis (GO:0002689)2.57811358
116regulation of membrane protein ectodomain proteolysis (GO:0051043)2.57319197
117cell migration involved in heart development (GO:0060973)2.56874497
118cellular response to vitamin D (GO:0071305)2.56037901
119alpha-linolenic acid metabolic process (GO:0036109)2.55832495
120negative regulation of complement activation (GO:0045916)2.55105768
121dermatan sulfate metabolic process (GO:0030205)2.54573951
122negative regulation of activin receptor signaling pathway (GO:0032926)2.53264974
123triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.52903287
124outer ear morphogenesis (GO:0042473)2.52669887
125dorsal/ventral neural tube patterning (GO:0021904)2.51814955
126extracellular fibril organization (GO:0043206)2.51774850
127glomerular visceral epithelial cell development (GO:0072015)2.50872420
128cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.50208591
129response to fluid shear stress (GO:0034405)2.50065792
130regulation of mesenchymal cell proliferation (GO:0010464)2.48012149
131ganglion development (GO:0061548)2.47593585
132regulation of plasminogen activation (GO:0010755)2.47289359
133cell proliferation involved in metanephros development (GO:0072203)2.47211443
134planar cell polarity pathway involved in neural tube closure (GO:0090179)2.46716809
135negative regulation of chemotaxis (GO:0050922)2.46684961
136protein localization to cell surface (GO:0034394)2.46303834
137fibril organization (GO:0097435)2.45877436
138type B pancreatic cell proliferation (GO:0044342)2.45539516
139lipoprotein metabolic process (GO:0042157)2.45483538
140positive regulation of mesenchymal cell proliferation (GO:0002053)2.45477116
141glomerular filtration (GO:0003094)2.45209863
142cellular response to interferon-alpha (GO:0035457)2.44868585
143non-canonical Wnt signaling pathway (GO:0035567)2.44867213
144blood vessel endothelial cell migration (GO:0043534)2.44088638
145smooth muscle tissue development (GO:0048745)2.43620687
146Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.43414675
147regulation of cardiac muscle tissue development (GO:0055024)2.42970740
148wound healing, spreading of cells (GO:0044319)2.42934352
149protein hydroxylation (GO:0018126)2.42286534
150cell proliferation in forebrain (GO:0021846)2.41567349
151negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.40715104
152embryonic cranial skeleton morphogenesis (GO:0048701)2.40009062
153regulation of cholesterol storage (GO:0010885)2.39634104
154limb bud formation (GO:0060174)2.38446744
155embryonic forelimb morphogenesis (GO:0035115)2.37881808
156substrate adhesion-dependent cell spreading (GO:0034446)2.37088192
157positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.35602997
158cellular response to BMP stimulus (GO:0071773)2.33962227
159response to BMP (GO:0071772)2.33962227
160cell proliferation involved in kidney development (GO:0072111)2.33171539
161embryonic digestive tract morphogenesis (GO:0048557)2.32782455

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.40910241
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.59858652
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.23171861
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.69306867
5CLOCK_20551151_ChIP-Seq_293T_Human3.64189868
6EZH2_22144423_ChIP-Seq_EOC_Human3.60055728
7RXR_22158963_ChIP-Seq_LIVER_Mouse3.36448353
8* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse3.21654412
9TP63_17297297_ChIP-ChIP_HaCaT_Human3.04314369
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.97854991
11CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.93401641
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.78483550
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.70800327
14ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.69606247
15WT1_19549856_ChIP-ChIP_CCG9911_Human2.63623344
16EGR1_23403033_ChIP-Seq_LIVER_Mouse2.61323285
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.61143383
18GBX2_23144817_ChIP-Seq_PC3_Human2.60281006
19TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.59035572
20CJUN_26792858_Chip-Seq_BT549_Human2.50087587
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.49857542
22NRF2_20460467_ChIP-Seq_MEFs_Mouse2.40323370
23NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.40323370
24RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.33949881
25EZH2_27304074_Chip-Seq_ESCs_Mouse2.31581766
26* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28335756
27* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.25473122
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.23672287
29* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.22998212
30* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.20428467
31* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.20428467
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.20158877
33NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.19474231
34* BRD4_25478319_ChIP-Seq_HGPS_Human2.16003341
35JARID2_20064375_ChIP-Seq_MESCs_Mouse2.14559959
36ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08598564
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06217118
38JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04658339
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.03510988
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.91945626
41* RNF2_27304074_Chip-Seq_ESCs_Mouse1.89494549
42* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.88153500
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87969187
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.87920809
45SALL4_18804426_ChIP-ChIP_XEN_Mouse1.86152526
46EP300_21415370_ChIP-Seq_HL-1_Mouse1.85005616
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83913887
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.79567145
49PPAR_26484153_Chip-Seq_NCI-H1993_Human1.77207082
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76754381
51FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.68927857
52* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.67211526
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61942917
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61270404
55* EZH2_27294783_Chip-Seq_ESCs_Mouse1.61207420
56TP53_18474530_ChIP-ChIP_U2OS_Human1.61085684
57VDR_22108803_ChIP-Seq_LS180_Human1.55350553
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54614739
59* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.54549430
60P300_19829295_ChIP-Seq_ESCs_Human1.53097943
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51752720
62* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.51501424
63CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.51153891
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.50553880
65* GATA2_21666600_ChIP-Seq_HMVEC_Human1.48047972
66HIF1A_21447827_ChIP-Seq_MCF-7_Human1.46641173
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46091890
68SMAD3_21741376_ChIP-Seq_HESCs_Human1.45582688
69SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.43918159
70SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.43918159
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43841336
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42842469
73SOX2_20726797_ChIP-Seq_SW620_Human1.38988383
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38331459
75RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37833395
76TP53_16413492_ChIP-PET_HCT116_Human1.36089656
77FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.35191638
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35031144
79RING1B_27294783_Chip-Seq_ESCs_Mouse1.33507847
80SMAD4_21799915_ChIP-Seq_A2780_Human1.32145857
81ZNF274_21170338_ChIP-Seq_K562_Hela1.32082829
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31903524
83ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30871619
84PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.29214412
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.28536019
86SMAD4_21741376_ChIP-Seq_HESCs_Human1.28017661
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27583115
88EGR1_19374776_ChIP-ChIP_THP-1_Human1.26316459
89DROSHA_22980978_ChIP-Seq_HELA_Human1.25891370
90JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24783288
91SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.23748563
92JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23638744
93FOXO3_23340844_ChIP-Seq_DLD1_Human1.23457331
94FUS_26573619_Chip-Seq_HEK293_Human1.23382441
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21361989
96WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19282400
97* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17329174
98POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17040427
99* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16772778
100CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15668335
101EWS_26573619_Chip-Seq_HEK293_Human1.15286596
102WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13693315
103CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13558696
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12863665
105OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12654823
106IRF8_22096565_ChIP-ChIP_GC-B_Human1.11948767
107SALL1_21062744_ChIP-ChIP_HESCs_Human1.11791325
108EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11772510
109HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11557711
110RNF2_27304074_Chip-Seq_NSC_Mouse1.11310745
111PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11302934
112PIAS1_25552417_ChIP-Seq_VCAP_Human1.11108436
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10673146
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09576498
115* AR_25329375_ChIP-Seq_VCAP_Human1.09451801
116SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08952224
117FLI1_27457419_Chip-Seq_LIVER_Mouse1.08898403
118UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08416902
119* EED_16625203_ChIP-ChIP_MESCs_Mouse1.07668143
120PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07663323
121FOXA2_19822575_ChIP-Seq_HepG2_Human1.07364448
122* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06949573
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06689027
124TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06689027
125NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.06428529
126MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05301231
127ESR2_21235772_ChIP-Seq_MCF-7_Human1.05176860
128P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04051799
129TBX20_22080862_ChIP-Seq_HEART_Mouse1.03201274
130TBX20_22328084_ChIP-Seq_HEART_Mouse1.03201274
131* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02873104
132AR_21572438_ChIP-Seq_LNCaP_Human1.02683918
133STAT3_23295773_ChIP-Seq_U87_Human1.02569126
134UBF1/2_26484160_Chip-Seq_HMECs_Human1.02393708
135NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02377251
136SMAD_19615063_ChIP-ChIP_OVARY_Human1.01930775
137POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01903863
138* KDM2B_26808549_Chip-Seq_REH_Human1.01824229
139SMAD4_21741376_ChIP-Seq_EPCs_Human1.01820050
140AHR_22903824_ChIP-Seq_MCF-7_Human1.01569565
141TAF15_26573619_Chip-Seq_HEK293_Human1.01366923
142KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01202485
143TP53_20018659_ChIP-ChIP_R1E_Mouse0.99975927
144KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99845725
145KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99845725
146KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99845725
147TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.99192948
148NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97243100
149IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97147769
150IRF8_27001747_Chip-Seq_BMDM_Mouse0.94579539
151ELK3_25401928_ChIP-Seq_HUVEC_Human0.94554172
152SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94362752
153SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93743717
154NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93623695
155THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92638855
156TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90770275
157* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.90618852
158PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90545828
159RXR_22108803_ChIP-Seq_LS180_Human0.89427999
160TCF4_18268006_ChIP-ChIP_LS174T_Human0.88689932
161VDR_24787735_ChIP-Seq_THP-1_Human0.88309079
162AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86388655
163TP63_23658742_ChIP-Seq_EP156T_Human0.86281205
164KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85877830
165HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.85619036
166STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85033399
167NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84809071
168AR_21909140_ChIP-Seq_LNCAP_Human0.84306756
169FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84076053
170ISL1_27105846_Chip-Seq_CPCs_Mouse0.84045127
171ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.82430648
172BCAT_22108803_ChIP-Seq_LS180_Human0.81718459

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.61299139
2MP0005275_abnormal_skin_tensile4.97105859
3MP0005503_abnormal_tendon_morphology4.89380875
4MP0003705_abnormal_hypodermis_morpholog4.21319133
5MP0003279_aneurysm3.29236228
6MP0001958_emphysema2.96102031
7MP0004272_abnormal_basement_membrane2.67683148
8MP0009384_cardiac_valve_regurgitation2.45193706
9MP0002060_abnormal_skin_morphology1.98432569
10MP0005508_abnormal_skeleton_morphology1.98172886
11MP0005623_abnormal_meninges_morphology1.92296375
12MP0006054_spinal_hemorrhage1.91114710
13MP0002139_abnormal_hepatobiliary_system1.89992489
14MP0005023_abnormal_wound_healing1.83042651
15MP0000049_abnormal_middle_ear1.82196986
16MP0005257_abnormal_intraocular_pressure1.78298127
17MP0010368_abnormal_lymphatic_system1.76809877
18MP0003566_abnormal_cell_adhesion1.74144156
19MP0005360_urolithiasis1.73609866
20MP0003195_calcinosis1.72351482
21MP0002295_abnormal_pulmonary_circulatio1.68719731
22MP0004133_heterotaxia1.63928330
23MP0003252_abnormal_bile_duct1.63218302
24MP0002896_abnormal_bone_mineralization1.59256717
25MP0001542_abnormal_bone_strength1.55793902
26MP0002282_abnormal_trachea_morphology1.50825080
27MP0000767_abnormal_smooth_muscle1.46578385
28MP0003091_abnormal_cell_migration1.44319761
29MP0002108_abnormal_muscle_morphology1.41066834
30MP0010030_abnormal_orbit_morphology1.40415696
31MP0009250_abnormal_appendicular_skeleto1.36973657
32MP0003385_abnormal_body_wall1.36306908
33MP0002102_abnormal_ear_morphology1.33935765
34MP0005390_skeleton_phenotype1.30702213
35MP0001879_abnormal_lymphatic_vessel1.29789882
36MP0005365_abnormal_bile_salt1.29414080
37MP0002115_abnormal_skeleton_extremities1.28969228
38MP0002933_joint_inflammation1.28597024
39MP0002998_abnormal_bone_remodeling1.25960638
40MP0001243_abnormal_dermal_layer1.24856150
41MP0002168_other_aberrant_phenotype1.24695417
42MP0000163_abnormal_cartilage_morphology1.21581719
43MP0002938_white_spotting1.17992716
44MP0009053_abnormal_anal_canal1.14473118
45MP0000462_abnormal_digestive_system1.12677887
46MP0003890_abnormal_embryonic-extraembry1.11215934
47MP0010386_abnormal_urinary_bladder1.10080065
48MP0001533_abnormal_skeleton_physiology1.09570736
49MP0004885_abnormal_endolymph1.08704842
50MP0000566_synostosis1.08347360
51MP0001299_abnormal_eye_distance/1.07435030
52MP0004858_abnormal_nervous_system1.07240188
53MP0005171_absent_coat_pigmentation1.06448180
54MP0002233_abnormal_nose_morphology1.06004230
55MP0010352_gastrointestinal_tract_polyps1.04810749
56MP0005085_abnormal_gallbladder_physiolo1.04081268
57MP0005058_abnormal_lysosome_morphology1.02138639
58MP0000733_abnormal_muscle_development1.00267845
59MP0003119_abnormal_digestive_system0.99630156
60MP0001348_abnormal_lacrimal_gland0.99296376
61MP0002113_abnormal_skeleton_development0.97811078
62MP0003300_gastrointestinal_ulcer0.97674639
63MP0003115_abnormal_respiratory_system0.97402950
64MP0003950_abnormal_plasma_membrane0.97338833
65MP0004145_abnormal_muscle_electrophysio0.96878586
66MP0000428_abnormal_craniofacial_morphol0.96002603
67MP0002116_abnormal_craniofacial_bone0.94651734
68MP0003942_abnormal_urinary_system0.94616759
69MP0005164_abnormal_response_to0.94605888
70MP0000534_abnormal_ureter_morphology0.92979032
71MP0000569_abnormal_digit_pigmentation0.92952597
72MP0005076_abnormal_cell_differentiation0.92929260
73MP0000343_altered_response_to0.92151564
74MP0004134_abnormal_chest_morphology0.90999775
75MP0010329_abnormal_lipoprotein_level0.90726021
76MP0002128_abnormal_blood_circulation0.90096834
77MP0002837_dystrophic_cardiac_calcinosis0.88233543
78MP0003795_abnormal_bone_structure0.87844584
79MP0004883_abnormal_blood_vessel0.86424522
80MP0002932_abnormal_joint_morphology0.84785705
81MP0009278_abnormal_bone_marrow0.84256683
82MP0008875_abnormal_xenobiotic_pharmacok0.84078724
83MP0002249_abnormal_larynx_morphology0.83405820
84MP0005197_abnormal_uvea_morphology0.83097319
85MP0001915_intracranial_hemorrhage0.82092747
86MP0009840_abnormal_foam_cell0.81351818
87MP0005595_abnormal_vascular_smooth0.81307525
88MP0000538_abnormal_urinary_bladder0.80757020
89MP0008004_abnormal_stomach_pH0.80678623
90MP0000026_abnormal_inner_ear0.79997243
91MP0002109_abnormal_limb_morphology0.79766801
92MP0003136_yellow_coat_color0.79280304
93MP0003938_abnormal_ear_development0.77520326
94MP0001614_abnormal_blood_vessel0.75503383
95MP0000778_abnormal_nervous_system0.74682344
96MP0001175_abnormal_lung_morphology0.74265386
97MP0000013_abnormal_adipose_tissue0.72408235
98MP0003937_abnormal_limbs/digits/tail_de0.70992970
99MP0000516_abnormal_urinary_system0.70473135
100MP0005367_renal/urinary_system_phenotyp0.70473135
101MP0009780_abnormal_chondrocyte_physiolo0.70004192
102MP0010307_abnormal_tumor_latency0.68471091
103MP0003191_abnormal_cellular_cholesterol0.68398966
104MP0003283_abnormal_digestive_organ0.67763074
105MP0005551_abnormal_eye_electrophysiolog0.67701287
106MP0002111_abnormal_tail_morphology0.67196891
107MP0002254_reproductive_system_inflammat0.66674114
108MP0003935_abnormal_craniofacial_develop0.66501670
109MP0000432_abnormal_head_morphology0.65871736
110MP0005646_abnormal_pituitary_gland0.65827149
111MP0003878_abnormal_ear_physiology0.65464645
112MP0005377_hearing/vestibular/ear_phenot0.65464645
113MP0005187_abnormal_penis_morphology0.64964248
114MP0002133_abnormal_respiratory_system0.64594700
115MP0005388_respiratory_system_phenotype0.64594700
116MP0002114_abnormal_axial_skeleton0.63839220
117MP0000230_abnormal_systemic_arterial0.63417576
118MP0002127_abnormal_cardiovascular_syste0.63067281
119MP0001756_abnormal_urination0.62599712
120MP0006072_abnormal_retinal_apoptosis0.62008718
121MP0002089_abnormal_postnatal_growth/wei0.61839441
122MP0002925_abnormal_cardiovascular_devel0.61301250
123MP0005620_abnormal_muscle_contractility0.60301444
124MP0003045_fibrosis0.60151454
125MP0003448_altered_tumor_morphology0.60075919
126MP0000537_abnormal_urethra_morphology0.60029563
127MP0003755_abnormal_palate_morphology0.59603100
128MP0005395_other_phenotype0.58669915
129MP0001177_atelectasis0.58096362
130MP0000249_abnormal_blood_vessel0.57616429
131MP0002135_abnormal_kidney_morphology0.57162357
132MP0005369_muscle_phenotype0.56261451
133MP0003806_abnormal_nucleotide_metabolis0.56180445
134MP0009697_abnormal_copulation0.55805913
135MP0008775_abnormal_heart_ventricle0.55636382
136MP0002697_abnormal_eye_size0.55516963
137MP0003941_abnormal_skin_development0.54537312
138MP0000003_abnormal_adipose_tissue0.53118585
139MP0000751_myopathy0.52157881

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.43617081
2Premature rupture of membranes (HP:0001788)6.76548453
3Ankle contracture (HP:0006466)4.96091487
4Aortic dissection (HP:0002647)4.59745627
5Cervical subluxation (HP:0003308)4.51923601
6Broad metatarsal (HP:0001783)4.28444259
7Soft skin (HP:0000977)4.17474870
8Shallow orbits (HP:0000586)4.12680652
9Aortic aneurysm (HP:0004942)3.94396513
10Peritonitis (HP:0002586)3.81231154
11Follicular hyperkeratosis (HP:0007502)3.72419339
12Vertebral compression fractures (HP:0002953)3.46508135
13Cerebral aneurysm (HP:0004944)3.45145998
14Atrophic scars (HP:0001075)3.36900072
15Bladder diverticulum (HP:0000015)3.34904458
16Keratoconus (HP:0000563)3.33956063
17Increased corneal curvature (HP:0100692)3.33956063
18Blue sclerae (HP:0000592)3.33182201
19Mitral valve prolapse (HP:0001634)3.27805697
20Abnormality of dentin (HP:0010299)3.25269808
21Neonatal short-limb short stature (HP:0008921)3.21239227
22Dilatation of the ascending aorta (HP:0005111)3.16017304
23Wormian bones (HP:0002645)3.12727104
24Type 1 muscle fiber predominance (HP:0003803)3.10529189
25Biconcave vertebral bodies (HP:0004586)3.07963387
26Fragile skin (HP:0001030)3.01968937
27Wrist flexion contracture (HP:0001239)3.01518073
28Osteolytic defects of the phalanges of the hand (HP:0009771)2.94144742
29Osteolytic defects of the hand bones (HP:0009699)2.94144742
30Genu recurvatum (HP:0002816)2.82186596
31Spondylolisthesis (HP:0003302)2.81590710
32Cupped ribs (HP:0000887)2.81511850
33Deep venous thrombosis (HP:0002625)2.80904677
34Bell-shaped thorax (HP:0001591)2.77681219
35Spinal rigidity (HP:0003306)2.77196492
36Myocardial infarction (HP:0001658)2.71882171
37Slender build (HP:0001533)2.71304128
38Morphological abnormality of the middle ear (HP:0008609)2.69245032
39Vascular tortuosity (HP:0004948)2.65035076
40Short hallux (HP:0010109)2.60916262
41Abnormality of the phalanges of the 2nd finger (HP:0009541)2.60339132
42Abnormal delivery (HP:0001787)2.59255165
43Ulnar bowing (HP:0003031)2.57794937
44Increased connective tissue (HP:0009025)2.56475529
45Ectopia lentis (HP:0001083)2.53009138
46Arterial tortuosity (HP:0005116)2.52772169
47Mitral stenosis (HP:0001718)2.50340815
48Abnormality of the acetabulum (HP:0003170)2.48152304
49Mesomelia (HP:0003027)2.45863624
50Hyperextensible skin (HP:0000974)2.42952308
51Aplasia/Hypoplasia of the hallux (HP:0008362)2.42010280
52Mild short stature (HP:0003502)2.38634090
53Abnormality of the middle phalanges of the toes (HP:0010183)2.38282347
54Osteoarthritis (HP:0002758)2.38273745
55Camptodactyly of toe (HP:0001836)2.36280076
56Aneurysm (HP:0002617)2.33063589
57Wide anterior fontanel (HP:0000260)2.30255232
58Complement deficiency (HP:0004431)2.28878834
59Narrow nasal bridge (HP:0000446)2.28477705
60Limited hip movement (HP:0008800)2.27294682
61Elbow flexion contracture (HP:0002987)2.26374037
62Nonimmune hydrops fetalis (HP:0001790)2.26199945
63Hip contracture (HP:0003273)2.22867720
64Absent frontal sinuses (HP:0002688)2.22637496
65Syringomyelia (HP:0003396)2.22328291
66Spinal cord lesions (HP:0100561)2.22328291
67Cardiovascular calcification (HP:0011915)2.21527083
68Femoral bowing (HP:0002980)2.18574169
69Joint laxity (HP:0001388)2.17005366
70Short 4th metacarpal (HP:0010044)2.16065374
71Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.16065374
72Overgrowth (HP:0001548)2.15502289
73Broad ribs (HP:0000885)2.12651008
74Preaxial foot polydactyly (HP:0001841)2.12491009
75Broad toe (HP:0001837)2.09514707
76Bulbous nose (HP:0000414)2.09407265
77Tibial bowing (HP:0002982)2.08882303
78Aplasia involving bones of the upper limbs (HP:0009823)2.08704423
79Aplasia of the phalanges of the hand (HP:0009802)2.08704423
80Aplasia involving bones of the extremities (HP:0009825)2.08704423
81Platyspondyly (HP:0000926)2.06000653
82Delayed closure of the anterior fontanelle (HP:0001476)2.05899064
83Coronal craniosynostosis (HP:0004440)2.05576191
84Cutaneous finger syndactyly (HP:0010554)2.05041306
85Abnormal cartilage morphology (HP:0002763)2.04066090
86Flat cornea (HP:0007720)2.03003895
87Bowel diverticulosis (HP:0005222)2.02482449
88Skin nodule (HP:0200036)2.00108015
89Hypoventilation (HP:0002791)1.98432052
90Abnormality of complement system (HP:0005339)1.97804826
91Beaking of vertebral bodies (HP:0004568)1.96504557
92Thin bony cortex (HP:0002753)1.96161671
93Aortic valve stenosis (HP:0001650)1.94908648
94Systemic lupus erythematosus (HP:0002725)1.94745876
95Xanthomatosis (HP:0000991)1.94646386
96Tarsal synostosis (HP:0008368)1.94194782
97Abnormality of the lumbar spine (HP:0100712)1.93930908
98Knee flexion contracture (HP:0006380)1.92987378
99Alopecia of scalp (HP:0002293)1.92862090
100Disproportionate tall stature (HP:0001519)1.92753803
101Increased variability in muscle fiber diameter (HP:0003557)1.92679837
102Persistence of primary teeth (HP:0006335)1.92375306
103Hypoplastic ischia (HP:0003175)1.92232155
104Striae distensae (HP:0001065)1.91798778
105Broad hallux (HP:0010055)1.91706357
106Coxa vara (HP:0002812)1.91625331
107Lymphangioma (HP:0100764)1.90676680
108Abnormality of the intrinsic pathway (HP:0010989)1.90245750
109Infantile muscular hypotonia (HP:0008947)1.89614797
110Broad long bones (HP:0005622)1.89187556
111Vitreoretinal degeneration (HP:0000655)1.88995450
112Mildly elevated creatine phosphokinase (HP:0008180)1.88024507
113Hematochezia (HP:0002573)1.87986658
114Pulmonary artery stenosis (HP:0004415)1.87933645
115Radial bowing (HP:0002986)1.87623329
116Hallux valgus (HP:0001822)1.87459031
117Deviation of the hallux (HP:0010051)1.87223693
118Synostosis of carpal bones (HP:0005048)1.86490453
119Asymmetry of the thorax (HP:0001555)1.86284646
120Abnormality of the 2nd finger (HP:0004100)1.85921159
121Cutaneous syndactyly (HP:0012725)1.84343602
122Synostosis involving bones of the lower limbs (HP:0009138)1.83877080
123Synostosis involving bones of the feet (HP:0009140)1.83877080
124Generalized amyotrophy (HP:0003700)1.82911691
125Hypoplasia of the iris (HP:0007676)1.82151581
126Turricephaly (HP:0000262)1.82046224
127Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.80821713
128Abnormality of the ischium (HP:0003174)1.80820409
129Inguinal hernia (HP:0000023)1.80715522
130Aortic regurgitation (HP:0001659)1.80338403
131Bowing of the arm (HP:0006488)1.77238515
132Bowed forearm bones (HP:0003956)1.77238515
133Partial duplication of the phalanx of hand (HP:0009999)1.76581240
134Ovoid vertebral bodies (HP:0003300)1.76522619
135Abnormality of the common coagulation pathway (HP:0010990)1.76440702
136Abnormality of the peritoneum (HP:0002585)1.75872216
137Gingival overgrowth (HP:0000212)1.72266422
138Joint stiffness (HP:0001387)1.72036078
139Abnormality of the phalanges of the 5th finger (HP:0004213)1.67713670
140Broad phalanx (HP:0006009)1.66916545
141Conical tooth (HP:0000698)1.65821445
142Premature skin wrinkling (HP:0100678)1.63463427
143Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.63015911
144Renal duplication (HP:0000075)1.62880163
145Hypoplasia of the odontoid process (HP:0003311)1.60662775
146Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.60291789

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.73324761
2PDGFRA3.63638078
3TTN3.60827018
4SIK13.32523785
5ADRBK22.91206001
6LATS12.90769079
7TRIB32.80055777
8AKT32.66387386
9TGFBR22.49462246
10PKN22.47760766
11FRK2.45614810
12ERN12.32568501
13RIPK12.30586159
14ACVR1B2.25213687
15GRK12.23306330
16EPHA32.03789495
17CAMK1D1.89534122
18EPHB21.82626341
19TRPM71.81718209
20NEK91.79558794
21LATS21.75294179
22PINK11.74978672
23BMPR1B1.70625926
24TIE11.64045655
25STK31.60148186
26FGFR21.55119754
27FLT31.53674151
28MET1.51044228
29PDGFRB1.46117158
30CASK1.46019933
31PTK61.42549341
32BMX1.41179014
33FGFR41.40224867
34JAK11.37199865
35MAPK151.32847821
36PAK21.31315846
37MARK11.25222511
38FER1.22246540
39ZAK1.21738204
40DAPK21.20682618
41PNCK1.20470841
42PRKD21.19874331
43RPS6KA41.14854124
44WNK41.12938535
45MYLK1.12740318
46CSF1R1.11329693
47PTK21.08817565
48TYRO31.08068724
49LIMK11.08056931
50FGFR11.07952641
51WNK31.03974326
52KIT1.03609551
53EIF2AK21.03379820
54ROCK11.02037736
55STK38L1.01597924
56NTRK31.00153785
57PIK3CA0.99556040
58PAK40.99550367
59CDC42BPA0.98640372
60ERBB40.98126409
61FGFR30.94064283
62NUAK10.93911102
63PTK2B0.92441790
64ERBB30.91353607
65MAP3K30.91145433
66GRK70.90512983
67CAMK1G0.89210146
68TYK20.88480864
69STK380.87600840
70RPS6KA20.85196070
71PIK3CG0.84819878
72NTRK20.81850269
73TGFBR10.81205689
74LRRK20.80226388
75PLK20.79997798
76OBSCN0.79580185
77PRKCG0.79417094
78MAPK130.79123825
79JAK30.77932795
80MKNK20.76650301
81SCYL20.75536019
82CDK60.75381625
83MAPKAPK30.75302913
84TNIK0.75263718
85RPS6KA60.75116016
86MTOR0.73404142
87MAP2K30.72005877
88PAK60.71222385
89DMPK0.69305386
90ABL20.68219917
91MOS0.66510041
92CAMK10.66068554
93CAMKK20.65515644
94INSRR0.64479657
95INSR0.63945519
96NLK0.63514816
97KDR0.63128614
98IGF1R0.62475230
99MAP3K100.62102905
100MST1R0.56458756
101PRKD30.56393756
102STK390.55860933
103GRK50.55841239
104SGK2230.55771888
105SGK4940.55771888
106PAK30.55599640
107GSK3A0.54669868
108TLK10.53283486
109PRKCH0.52628815
110CAMK2A0.51077532
111OXSR10.50184975
112RPS6KC10.49613042
113RPS6KL10.49613042
114SGK20.49531334
115DYRK1B0.49050660
116TBK10.47633853
117EPHA40.45124425
118MAP4K20.44593645
119PRKG20.42793816
120MAP2K10.40570726
121CHUK0.39797489
122SRC0.39516668
123RET0.38911909
124PKN10.38373173
125MAPK70.37923363
126ABL10.37849880
127MARK20.36743320
128BCKDK0.36418393
129CSK0.35805655
130PRKD10.35479951
131PRKG10.34093396
132PRKCE0.34086805
133MAP3K40.33136599
134CAMKK10.32033205
135ROCK20.31609326
136PRKAA20.30619091
137EGFR0.30584555
138MAPK10.29455883
139ILK0.28780292
140ADRBK10.28401092
141MAP3K140.27965343
142JAK20.27702307
143NTRK10.27084709
144IKBKB0.27010536
145PBK0.26510549
146FGR0.25346148
147CAMK40.23742405
148STK100.23609669
149EPHB10.23322460

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.41849527
2Hedgehog signaling pathway_Homo sapiens_hsa043403.11704159
3Complement and coagulation cascades_Homo sapiens_hsa046103.05743288
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.05371225
5Staphylococcus aureus infection_Homo sapiens_hsa051502.34272543
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.29809997
7Caffeine metabolism_Homo sapiens_hsa002322.26678293
8Focal adhesion_Homo sapiens_hsa045102.15974116
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.13250917
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.07643138
11Nitrogen metabolism_Homo sapiens_hsa009102.05650995
12Malaria_Homo sapiens_hsa051441.96215316
13Protein digestion and absorption_Homo sapiens_hsa049741.90548218
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.84197765
15Fatty acid degradation_Homo sapiens_hsa000711.76583823
16Tryptophan metabolism_Homo sapiens_hsa003801.74903019
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.72241274
18PPAR signaling pathway_Homo sapiens_hsa033201.70490739
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.66612813
20Melanogenesis_Homo sapiens_hsa049161.58027715
21Arginine biosynthesis_Homo sapiens_hsa002201.52891095
22Amoebiasis_Homo sapiens_hsa051461.51657192
23Phototransduction_Homo sapiens_hsa047441.49011936
24Proteoglycans in cancer_Homo sapiens_hsa052051.47088012
25Wnt signaling pathway_Homo sapiens_hsa043101.37069034
26Chemical carcinogenesis_Homo sapiens_hsa052041.36947963
27Axon guidance_Homo sapiens_hsa043601.36407139
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.35054151
29Starch and sucrose metabolism_Homo sapiens_hsa005001.33989044
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33752957
31Fatty acid metabolism_Homo sapiens_hsa012121.30583497
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.28569012
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26070809
34Vascular smooth muscle contraction_Homo sapiens_hsa042701.25872630
35Adherens junction_Homo sapiens_hsa045201.24971883
36Retinol metabolism_Homo sapiens_hsa008301.24944941
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.24941104
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24738017
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.24430194
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.24005847
41Small cell lung cancer_Homo sapiens_hsa052221.21910580
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21698848
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20614133
44Lysosome_Homo sapiens_hsa041421.20489592
45Circadian entrainment_Homo sapiens_hsa047131.19336137
46Selenocompound metabolism_Homo sapiens_hsa004501.18198054
47Dorso-ventral axis formation_Homo sapiens_hsa043201.16091131
48TGF-beta signaling pathway_Homo sapiens_hsa043501.14805969
49Morphine addiction_Homo sapiens_hsa050321.14192455
50PI3K-Akt signaling pathway_Homo sapiens_hsa041511.12132135
51Peroxisome_Homo sapiens_hsa041461.08731934
52Lysine degradation_Homo sapiens_hsa003101.05303828
53Insulin secretion_Homo sapiens_hsa049111.04284212
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03889193
55Calcium signaling pathway_Homo sapiens_hsa040201.03100188
56Mineral absorption_Homo sapiens_hsa049781.01330725
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00568548
58Ether lipid metabolism_Homo sapiens_hsa005650.97703151
59Glutamatergic synapse_Homo sapiens_hsa047240.97493885
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.95723410
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95500076
62Histidine metabolism_Homo sapiens_hsa003400.95212881
63* Phagosome_Homo sapiens_hsa041450.93965919
64Nicotine addiction_Homo sapiens_hsa050330.91974238
65MicroRNAs in cancer_Homo sapiens_hsa052060.91297479
66Gastric acid secretion_Homo sapiens_hsa049710.90821632
67Oxytocin signaling pathway_Homo sapiens_hsa049210.88867948
68Renin secretion_Homo sapiens_hsa049240.88512285
69Bladder cancer_Homo sapiens_hsa052190.87334363
70Bile secretion_Homo sapiens_hsa049760.86821314
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86601655
72beta-Alanine metabolism_Homo sapiens_hsa004100.86367112
73Linoleic acid metabolism_Homo sapiens_hsa005910.86240318
74Renin-angiotensin system_Homo sapiens_hsa046140.85998273
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85536046
76Salivary secretion_Homo sapiens_hsa049700.85484449
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85345854
78Propanoate metabolism_Homo sapiens_hsa006400.84766928
79Steroid biosynthesis_Homo sapiens_hsa001000.83256342
80Other glycan degradation_Homo sapiens_hsa005110.82260598
81Ras signaling pathway_Homo sapiens_hsa040140.81760146
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81129798
83Melanoma_Homo sapiens_hsa052180.80241202
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80165139
85One carbon pool by folate_Homo sapiens_hsa006700.80161861
86Rap1 signaling pathway_Homo sapiens_hsa040150.79607809
87Taste transduction_Homo sapiens_hsa047420.79558694
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79426614
89Basal cell carcinoma_Homo sapiens_hsa052170.78691884
90cAMP signaling pathway_Homo sapiens_hsa040240.78430682
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76367590
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76016438
93GABAergic synapse_Homo sapiens_hsa047270.75821400
94Phenylalanine metabolism_Homo sapiens_hsa003600.75762200
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74343414
96Dilated cardiomyopathy_Homo sapiens_hsa054140.73881400
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73054732
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71367156
99Serotonergic synapse_Homo sapiens_hsa047260.70746517
100Olfactory transduction_Homo sapiens_hsa047400.70578368
101Arginine and proline metabolism_Homo sapiens_hsa003300.68052322
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67441920
103Tight junction_Homo sapiens_hsa045300.66303301
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.65660585
105Hippo signaling pathway_Homo sapiens_hsa043900.65099982
106Prostate cancer_Homo sapiens_hsa052150.65098056
107Cocaine addiction_Homo sapiens_hsa050300.65042877
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64756901
109Prion diseases_Homo sapiens_hsa050200.64199483
110Sulfur metabolism_Homo sapiens_hsa009200.63725456
111Cholinergic synapse_Homo sapiens_hsa047250.62997531
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62551630
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62497313
114Systemic lupus erythematosus_Homo sapiens_hsa053220.62156419
115Insulin resistance_Homo sapiens_hsa049310.61414917
116MAPK signaling pathway_Homo sapiens_hsa040100.60412018
117Tyrosine metabolism_Homo sapiens_hsa003500.59479383
118Chronic myeloid leukemia_Homo sapiens_hsa052200.56661371
119ABC transporters_Homo sapiens_hsa020100.56124833
120Gap junction_Homo sapiens_hsa045400.55772424
121Vitamin digestion and absorption_Homo sapiens_hsa049770.55334072
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55070761
123Pancreatic cancer_Homo sapiens_hsa052120.54816571
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54785337
125TNF signaling pathway_Homo sapiens_hsa046680.53892547
126Sphingolipid metabolism_Homo sapiens_hsa006000.53413459
127Butanoate metabolism_Homo sapiens_hsa006500.52900577
128Toxoplasmosis_Homo sapiens_hsa051450.50835861
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.50785896
130Long-term depression_Homo sapiens_hsa047300.50742889
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.49700223
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49682383
133Dopaminergic synapse_Homo sapiens_hsa047280.49499545
134Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49046528
135Rheumatoid arthritis_Homo sapiens_hsa053230.48950840
136Platelet activation_Homo sapiens_hsa046110.47106448
137Fatty acid biosynthesis_Homo sapiens_hsa000610.47039342
1382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46764653
139Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46693337
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46578753
141Thyroid hormone synthesis_Homo sapiens_hsa049180.46511902
142Pertussis_Homo sapiens_hsa051330.46017008
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.45705637
144Leishmaniasis_Homo sapiens_hsa051400.45661394
145Osteoclast differentiation_Homo sapiens_hsa043800.43723055
146Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43331890
147Pathways in cancer_Homo sapiens_hsa052000.43224898
148Ovarian steroidogenesis_Homo sapiens_hsa049130.42858291
149p53 signaling pathway_Homo sapiens_hsa041150.42573234
150Legionellosis_Homo sapiens_hsa051340.42504926
151Apoptosis_Homo sapiens_hsa042100.41511312
152Arachidonic acid metabolism_Homo sapiens_hsa005900.39925486
153Estrogen signaling pathway_Homo sapiens_hsa049150.38120986
154Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37965771
155Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37897034
156Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37708995
157GnRH signaling pathway_Homo sapiens_hsa049120.36280995
158Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.32346054

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