COLGALT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of two enzymes that transfers galactose moieties to hydroxylysine residues of collagen and mannose binding lectin. This gene is constitutively expressed and encodes a soluble protein that localizes to the endoplasmic reticulum. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to endosome (GO:0036010)4.39459543
2barbed-end actin filament capping (GO:0051016)4.19896503
3protein maturation by protein folding (GO:0022417)4.10046590
4membrane raft organization (GO:0031579)3.86123236
5apoptotic cell clearance (GO:0043277)3.73876709
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.56056752
7positive regulation by symbiont of host defense response (GO:0052509)3.46418034
8modulation by symbiont of host defense response (GO:0052031)3.46418034
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.46418034
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.46418034
11positive regulation by organism of defense response of other organism involved in symbiotic interact3.46418034
12modulation by symbiont of host immune response (GO:0052553)3.46418034
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.36571396
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.36571396
15regulation of early endosome to late endosome transport (GO:2000641)3.29968941
16basement membrane organization (GO:0071711)3.26010614
17negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.22039099
18neutrophil activation involved in immune response (GO:0002283)3.18995030
19low-density lipoprotein particle clearance (GO:0034383)3.12950540
20antigen processing and presentation of endogenous antigen (GO:0019883)3.12849908
21cell adhesion mediated by integrin (GO:0033627)3.08725242
22regulation of interferon-beta biosynthetic process (GO:0045357)3.07183320
23regulation of metalloenzyme activity (GO:0048552)3.04144368
24endodermal cell differentiation (GO:0035987)3.03059242
25macrophage activation involved in immune response (GO:0002281)3.01292170
26regulation of cholesterol storage (GO:0010885)3.00169339
27glycosphingolipid catabolic process (GO:0046479)2.99070803
28retina vasculature morphogenesis in camera-type eye (GO:0061299)2.97138768
29COPI coating of Golgi vesicle (GO:0048205)2.96108322
30Golgi transport vesicle coating (GO:0048200)2.96108322
31wound healing, spreading of epidermal cells (GO:0035313)2.93510109
32keratan sulfate catabolic process (GO:0042340)2.89772072
33skin morphogenesis (GO:0043589)2.83971109
34pentose-phosphate shunt (GO:0006098)2.83265359
35protein hydroxylation (GO:0018126)2.82357495
36response to laminar fluid shear stress (GO:0034616)2.82084074
37positive regulation of interferon-alpha production (GO:0032727)2.80941296
38dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.80733403
39regulation of superoxide anion generation (GO:0032928)2.80396721
40immunoglobulin mediated immune response (GO:0016064)2.78240885
41pinocytosis (GO:0006907)2.76541287
42Arp2/3 complex-mediated actin nucleation (GO:0034314)2.73085479
43positive regulation of extracellular matrix organization (GO:1903055)2.72320403
44stress fiber assembly (GO:0043149)2.68888059
45regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.68078986
46cortical actin cytoskeleton organization (GO:0030866)2.66432030
47collagen fibril organization (GO:0030199)2.61882337
48negative regulation of nitric-oxide synthase activity (GO:0051001)2.61828811
49positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.61795016
50regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.61692667
51T cell apoptotic process (GO:0070231)2.61096446
52glycolipid catabolic process (GO:0019377)2.60744368
53regulation of integrin-mediated signaling pathway (GO:2001044)2.60732843
54response to thyroid hormone (GO:0097066)2.60305260
55regulation of interferon-alpha production (GO:0032647)2.59617984
56positive regulation of receptor recycling (GO:0001921)2.59246653
57maternal placenta development (GO:0001893)2.56778973
58regulation of SMAD protein import into nucleus (GO:0060390)2.54195059
59type B pancreatic cell proliferation (GO:0044342)2.54074343
60hemidesmosome assembly (GO:0031581)2.53757116
61NADPH regeneration (GO:0006740)2.53709069
62membrane protein ectodomain proteolysis (GO:0006509)2.53575452
63maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.50923184
64chondrocyte proliferation (GO:0035988)2.50840707
65glucose catabolic process (GO:0006007)2.49251688
66germ cell migration (GO:0008354)2.49123237
67cellular copper ion homeostasis (GO:0006878)2.49006701
68vascular endothelial growth factor signaling pathway (GO:0038084)2.46555111
69glucose 6-phosphate metabolic process (GO:0051156)2.46296328
70response to interferon-alpha (GO:0035455)2.45021025
71positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.45019434
72positive regulation of blood vessel endothelial cell migration (GO:0043536)2.44505486
73positive regulation of SMAD protein import into nucleus (GO:0060391)2.43968219
74negative regulation of nitric oxide biosynthetic process (GO:0045019)2.43526618
75hyaluronan catabolic process (GO:0030214)2.43222539
76regulation of translational termination (GO:0006449)2.42815036
77negative regulation of fatty acid transport (GO:2000192)2.41683243
78response to peptidoglycan (GO:0032494)2.41272544
79regulation of nuclease activity (GO:0032069)2.41261913
80regulation of protein heterodimerization activity (GO:0043497)2.41239688
81regulation of apoptotic process involved in morphogenesis (GO:1902337)2.41239138
82phagocytosis, recognition (GO:0006910)2.40518437
83COPII vesicle coating (GO:0048208)2.40348878
84pyrimidine nucleoside salvage (GO:0043097)2.40289168
85pyrimidine-containing compound salvage (GO:0008655)2.40289168
86positive regulation of endothelial cell apoptotic process (GO:2000353)2.40283751
87respiratory burst (GO:0045730)2.39979558
88negative regulation of phagocytosis (GO:0050765)2.39783369
89folic acid-containing compound biosynthetic process (GO:0009396)2.39116736
90positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.38285976
91positive regulation of Cdc42 GTPase activity (GO:0043089)2.38258520
92regulation of interleukin-12 biosynthetic process (GO:0045075)2.38116796
93protein retention in ER lumen (GO:0006621)2.38007032
94protein heterotrimerization (GO:0070208)2.37836523
95UDP-N-acetylglucosamine metabolic process (GO:0006047)2.37750106
96amino sugar catabolic process (GO:0046348)2.37625268
97cellular response to thyroid hormone stimulus (GO:0097067)2.37497333
98B cell mediated immunity (GO:0019724)2.36807089
99extracellular fibril organization (GO:0043206)2.36731207
100positive regulation of B cell differentiation (GO:0045579)2.36717814
101nucleobase-containing small molecule interconversion (GO:0015949)2.36270262
102production of molecular mediator involved in inflammatory response (GO:0002532)2.36263414
103protein carboxylation (GO:0018214)2.36034855
104peptidyl-glutamic acid carboxylation (GO:0017187)2.36034855
105decidualization (GO:0046697)2.35931546
106collagen metabolic process (GO:0032963)2.35747883
107regulation of cytokine secretion involved in immune response (GO:0002739)2.34797315
108regulation of integrin activation (GO:0033623)2.34379619
109membrane lipid catabolic process (GO:0046466)2.33806896
110ceramide catabolic process (GO:0046514)2.33756761
111positive regulation of protein import into nucleus, translocation (GO:0033160)2.33728448
112regulation of membrane protein ectodomain proteolysis (GO:0051043)2.33411073
113fibril organization (GO:0097435)2.33117505
114cell migration involved in heart development (GO:0060973)2.32953468
115cellular response to unfolded protein (GO:0034620)2.32132658
116collagen catabolic process (GO:0030574)2.31755002
117cortical cytoskeleton organization (GO:0030865)2.31582559
118positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.31507109
119regulation of macrophage cytokine production (GO:0010935)2.31278132
120sphingolipid catabolic process (GO:0030149)2.31210695
121positive regulation of gamma-delta T cell activation (GO:0046645)2.30891206
122negative regulation of interleukin-12 production (GO:0032695)2.30074934
123angiogenesis involved in wound healing (GO:0060055)2.29956311
124protein N-linked glycosylation via asparagine (GO:0018279)2.29482954
125ER-nucleus signaling pathway (GO:0006984)2.28503854
126vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.28494532
127endothelial cell morphogenesis (GO:0001886)2.28440577
128natural killer cell differentiation (GO:0001779)2.28300601
129response to muramyl dipeptide (GO:0032495)2.28295886
130antigen processing and presentation via MHC class Ib (GO:0002475)2.27905262
131vesicle coating (GO:0006901)2.27616733
132peptidyl-asparagine modification (GO:0018196)2.26645270
133extracellular matrix disassembly (GO:0022617)2.26426422
134cell-substrate junction assembly (GO:0007044)2.26376730
135retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.25268032
136positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.24800227
137detection of molecule of bacterial origin (GO:0032490)2.24616162
138negative regulation of protein autophosphorylation (GO:0031953)2.24405693
139activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.23965154
140myeloid cell homeostasis (GO:0002262)2.23484292
141peptidyl-proline hydroxylation (GO:0019511)2.23290428
142positive regulation of nuclease activity (GO:0032075)2.23286252
143DNA unwinding involved in DNA replication (GO:0006268)2.22825885
144regulation of translational fidelity (GO:0006450)2.22545585
145vagina development (GO:0060068)2.22079021
146wound healing, spreading of cells (GO:0044319)2.22000966
147platelet aggregation (GO:0070527)2.21156026
148macrophage differentiation (GO:0030225)2.21029617
149UV protection (GO:0009650)2.20644341
150positive regulation of blood coagulation (GO:0030194)2.20599851
151positive regulation of hemostasis (GO:1900048)2.20599851
152substrate adhesion-dependent cell spreading (GO:0034446)2.20278657
153mannose metabolic process (GO:0006013)2.19871081
154positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.19790682
155regulation of extracellular matrix disassembly (GO:0010715)2.19449527
156oligosaccharide catabolic process (GO:0009313)2.19447996
157regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.19066633
158positive regulation of histone deacetylation (GO:0031065)2.19022691
159positive regulation of natural killer cell differentiation (GO:0032825)2.17806433
160substrate-dependent cell migration (GO:0006929)2.17778969
1614-hydroxyproline metabolic process (GO:0019471)2.17588847
162heterochromatin organization (GO:0070828)2.17221079
163lymphocyte apoptotic process (GO:0070227)2.16239931
164multicellular organismal macromolecule metabolic process (GO:0044259)2.15713392
165regulation of B cell differentiation (GO:0045577)2.15540308
166regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.14628030
167apoptotic process involved in morphogenesis (GO:0060561)2.14579742
168response to fluid shear stress (GO:0034405)2.14041877
169endoplasmic reticulum unfolded protein response (GO:0030968)2.12095350

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.26990940
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.74446891
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.21300756
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.07513972
5MYC_22102868_ChIP-Seq_BL_Human2.59232895
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.52673912
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.44517511
8MYB_21317192_ChIP-Seq_ERMYB_Mouse2.32955035
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.31107910
10VDR_21846776_ChIP-Seq_THP-1_Human2.26996134
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.26694640
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.21457475
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.12601298
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10915685
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.06316288
16CLOCK_20551151_ChIP-Seq_293T_Human2.05865427
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.05050734
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.00009290
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99874071
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.97852796
21IRF8_27001747_Chip-Seq_BMDM_Mouse1.97530359
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.96516131
23BRD4_27068464_Chip-Seq_AML-cells_Mouse1.96444314
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.94973843
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.93844497
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.90266789
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.80408446
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.79889047
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.78769753
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.72287834
31DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.68194760
32TCF7_22412390_ChIP-Seq_EML_Mouse1.67690578
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.64823843
34RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.64028352
35VDR_24763502_ChIP-Seq_THP-1_Human1.62129878
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.61189216
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.58013254
38MAF_26560356_Chip-Seq_TH1_Human1.57278113
39PPARA_22158963_ChIP-Seq_LIVER_Mouse1.56204254
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.54308258
41TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54155957
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.50443598
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49732168
44GATA1_22025678_ChIP-Seq_K562_Human1.49098761
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.48338436
46RXR_22158963_ChIP-Seq_LIVER_Mouse1.47233115
47STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.46763286
48SCL_19346495_ChIP-Seq_HPC-7_Human1.45459793
49CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.45312337
50SPI1_23547873_ChIP-Seq_NB4_Human1.45205334
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42624854
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41884653
53KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41811531
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.41694986
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.41239541
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40629271
57MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40077456
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39746585
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39516607
60RUNX1_22412390_ChIP-Seq_EML_Mouse1.39155123
61RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36626166
62JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.36170493
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35531627
64FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.35007228
65FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.34958361
66TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34662269
67KDM2B_26808549_Chip-Seq_DND41_Human1.33191452
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31627084
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31048204
70HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30379595
71UTX_26944678_Chip-Seq_JUKART_Human1.30190484
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30080806
73ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30034515
74MYC_19030024_ChIP-ChIP_MESCs_Mouse1.29581168
75ATF3_27146783_Chip-Seq_COLON_Human1.26917489
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26898472
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26141148
78TFEB_21752829_ChIP-Seq_HELA_Human1.25273711
79KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25079875
80UBF1/2_26484160_Chip-Seq_HMECs_Human1.23805013
81BRD4_25478319_ChIP-Seq_HGPS_Human1.23772615
82LXR_22292898_ChIP-Seq_THP-1_Human1.23416067
83MYB_26560356_Chip-Seq_TH2_Human1.22924475
84E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22901412
85SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21343076
86NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.21096405
87TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20981361
88MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20186641
89IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18402392
90RACK7_27058665_Chip-Seq_MCF-7_Human1.17944164
91MYB_26560356_Chip-Seq_TH1_Human1.17155303
92DCP1A_22483619_ChIP-Seq_HELA_Human1.16887414
93STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15349726
94PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13204272
95UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10027990
96SPI1_23127762_ChIP-Seq_K562_Human1.09851144
97LXR_22158963_ChIP-Seq_LIVER_Mouse1.09817548
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08849096
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08708308
100NCOR1_26117541_ChIP-Seq_K562_Human1.07127095
101ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06682353
102PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06585731
103PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06003985
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05205439
105THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04554123
106P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04437320
107ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03792888
108MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03364238
109GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02971703
110KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02967280
111STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.02435089
112NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02227277
113SMAD_19615063_ChIP-ChIP_OVARY_Human1.01330264
114ESR1_21235772_ChIP-Seq_MCF-7_Human1.00893136
115CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00232328
116AR_21909140_ChIP-Seq_LNCAP_Human1.00032550
117TP53_22127205_ChIP-Seq_IMR90_Human0.99802957
118JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99387786
119NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99315174
120CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99250649
121CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98959333
122ZNF263_19887448_ChIP-Seq_K562_Human0.98815507
123TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98685045
124FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98289033
125TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98001467
126TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97727594
127GABP_19822575_ChIP-Seq_HepG2_Human0.97390432
128ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97261252
129E2F4_17652178_ChIP-ChIP_JURKAT_Human0.97136536
130SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97129005
131SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97129005
132FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97039819
133CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96457179
134E2F1_21310950_ChIP-Seq_MCF-7_Human0.96277433
135PU_27001747_Chip-Seq_BMDM_Mouse0.94634647
136FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.94338831

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.36953467
2MP0003705_abnormal_hypodermis_morpholog3.51959087
3MP0003950_abnormal_plasma_membrane2.82720740
4MP0006054_spinal_hemorrhage2.66521839
5MP0003303_peritoneal_inflammation2.32573990
6MP0003566_abnormal_cell_adhesion2.31975236
7MP0003436_decreased_susceptibility_to2.29492511
8MP0010352_gastrointestinal_tract_polyps2.28904877
9MP0005275_abnormal_skin_tensile2.23550818
10MP0001835_abnormal_antigen_presentation2.08712761
11MP0003279_aneurysm1.98039866
12MP0008260_abnormal_autophagy1.93452578
13MP0005503_abnormal_tendon_morphology1.90727534
14MP0004272_abnormal_basement_membrane1.85608310
15MP0005058_abnormal_lysosome_morphology1.82864369
16MP0003300_gastrointestinal_ulcer1.82292569
17MP0005451_abnormal_body_composition1.75517013
18MP0005076_abnormal_cell_differentiation1.75112040
19MP0001958_emphysema1.73644148
20MP0003191_abnormal_cellular_cholesterol1.71120583
21MP0009840_abnormal_foam_cell1.65542034
22MP0005023_abnormal_wound_healing1.64118227
23MP0002419_abnormal_innate_immunity1.63838661
24MP0000685_abnormal_immune_system1.63417331
25MP0009278_abnormal_bone_marrow1.59274462
26MP0001533_abnormal_skeleton_physiology1.55842937
27MP0010307_abnormal_tumor_latency1.54559030
28MP0003806_abnormal_nucleotide_metabolis1.54461449
29MP0002452_abnormal_antigen_presenting1.44432691
30MP0005464_abnormal_platelet_physiology1.43051609
31MP0009785_altered_susceptibility_to1.42159220
32MP0006082_CNS_inflammation1.37502165
33MP0002396_abnormal_hematopoietic_system1.36894193
34MP0003448_altered_tumor_morphology1.35184589
35MP0005000_abnormal_immune_tolerance1.34931213
36MP0005025_abnormal_response_to1.33714931
37MP0001545_abnormal_hematopoietic_system1.33545342
38MP0005397_hematopoietic_system_phenotyp1.33545342
39MP0002877_abnormal_melanocyte_morpholog1.32941897
40MP0005257_abnormal_intraocular_pressure1.32436594
41MP0000015_abnormal_ear_pigmentation1.31548242
42MP0002933_joint_inflammation1.31380104
43MP0005165_increased_susceptibility_to1.31231649
44MP0000858_altered_metastatic_potential1.30659925
45MP0003172_abnormal_lysosome_physiology1.30439219
46MP0004808_abnormal_hematopoietic_stem1.29646670
47MP0005408_hypopigmentation1.29410066
48MP0000343_altered_response_to1.28033520
49MP0003091_abnormal_cell_migration1.27774627
50MP0005171_absent_coat_pigmentation1.25775070
51MP0001800_abnormal_humoral_immune1.25646879
52MP0005387_immune_system_phenotype1.22733917
53MP0001790_abnormal_immune_system1.22733917
54MP0002148_abnormal_hypersensitivity_rea1.20234996
55MP0004947_skin_inflammation1.19876808
56MP0001915_intracranial_hemorrhage1.18409519
57MP0002060_abnormal_skin_morphology1.18333925
58MP0001853_heart_inflammation1.17997721
59MP0002254_reproductive_system_inflammat1.17429327
60MP0004233_abnormal_muscle_weight1.17140805
61MP0001542_abnormal_bone_strength1.14055705
62MP0002998_abnormal_bone_remodeling1.13969864
63MP0010030_abnormal_orbit_morphology1.12508361
64MP0000767_abnormal_smooth_muscle1.11876221
65MP0005390_skeleton_phenotype1.11769241
66MP0001819_abnormal_immune_cell1.09753937
67MP0002420_abnormal_adaptive_immunity1.09591859
68MP0002723_abnormal_immune_serum1.08902573
69MP0002405_respiratory_system_inflammati1.07029247
70MP0010368_abnormal_lymphatic_system1.05971753
71MP0003111_abnormal_nucleus_morphology1.04875039
72MP0000733_abnormal_muscle_development1.04518805
73MP0001845_abnormal_inflammatory_respons1.03321584
74MP0010155_abnormal_intestine_physiology1.02954006
75MP0002166_altered_tumor_susceptibility1.02175249
76MP0005197_abnormal_uvea_morphology0.98582091
77MP0009333_abnormal_splenocyte_physiolog0.97539848
78MP0000371_diluted_coat_color0.96976531
79MP0002896_abnormal_bone_mineralization0.96477749
80MP0000490_abnormal_crypts_of0.95219308
81MP0000749_muscle_degeneration0.94359547
82MP0000689_abnormal_spleen_morphology0.93636230
83MP0002398_abnormal_bone_marrow0.93616494
84MP0004510_myositis0.93594300
85MP0005360_urolithiasis0.91556779
86MP0003186_abnormal_redox_activity0.90929801
87MP0000465_gastrointestinal_hemorrhage0.90125098
88MP0003795_abnormal_bone_structure0.88997178
89MP0005623_abnormal_meninges_morphology0.88917310
90MP0005621_abnormal_cell_physiology0.88883111
91MP0000716_abnormal_immune_system0.88690567
92MP0001243_abnormal_dermal_layer0.88499693
93MP0008469_abnormal_protein_level0.88461843
94MP0005508_abnormal_skeleton_morphology0.88314935
95MP0000372_irregular_coat_pigmentation0.88232842
96MP0003724_increased_susceptibility_to0.88210025
97MP0005409_darkened_coat_color0.87338525
98MP0000604_amyloidosis0.86739161
99MP0000358_abnormal_cell_content/0.86490927
100MP0002429_abnormal_blood_cell0.85470437
101MP0002722_abnormal_immune_system0.85398041
102MP0003828_pulmonary_edema0.85234627
103MP0002006_tumorigenesis0.84952089
104MP0009384_cardiac_valve_regurgitation0.84906996
105MP0004858_abnormal_nervous_system0.84300515
106MP0005330_cardiomyopathy0.84295686
107MP0010234_abnormal_vibrissa_follicle0.82732370
108MP0001661_extended_life_span0.82560194
109MP0003075_altered_response_to0.82431868
110MP0004883_abnormal_blood_vessel0.81971744
111MP0000598_abnormal_liver_morphology0.81630770
112MP0000249_abnormal_blood_vessel0.81192842
113MP0003453_abnormal_keratinocyte_physiol0.81143284
114MP0004185_abnormal_adipocyte_glucose0.81019368
115MP0001879_abnormal_lymphatic_vessel0.80875983
116MP0001849_ear_inflammation0.80391565
117MP0008007_abnormal_cellular_replicative0.79296269
118MP0004197_abnormal_fetal_growth/weight/0.76170815
119MP0001730_embryonic_growth_arrest0.76130273
120MP0000609_abnormal_liver_physiology0.75734376
121MP0005595_abnormal_vascular_smooth0.74791229
122MP0002019_abnormal_tumor_incidence0.73345544
123MP0003252_abnormal_bile_duct0.72918104
124MP0002128_abnormal_blood_circulation0.72720085
125MP0002295_abnormal_pulmonary_circulatio0.72444532
126MP0001614_abnormal_blood_vessel0.72377870
127MP0000003_abnormal_adipose_tissue0.72039036
128MP0005384_cellular_phenotype0.71820704
129MP0005166_decreased_susceptibility_to0.70874553
130MP0005193_abnormal_anterior_eye0.70712694
131MP0002086_abnormal_extraembryonic_tissu0.70580529
132MP0005164_abnormal_response_to0.70260237
133MP0009053_abnormal_anal_canal0.69803238
134MP0004957_abnormal_blastocyst_morpholog0.69617448
135MP0010094_abnormal_chromosome_stability0.67299295
136MP0003077_abnormal_cell_cycle0.66967317
137MP0000747_muscle_weakness0.66887519
138MP0001216_abnormal_epidermal_layer0.66253297
139MP0002075_abnormal_coat/hair_pigmentati0.65702287

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.92656972
2Premature rupture of membranes (HP:0001788)4.13577233
3Cerebral aneurysm (HP:0004944)3.58359378
4Ankle contracture (HP:0006466)3.48697818
5Cervical subluxation (HP:0003308)3.42901181
6Peritonitis (HP:0002586)3.16439908
7Eczematoid dermatitis (HP:0000976)3.03634589
8Recurrent gram-negative bacterial infections (HP:0005420)2.96871489
9Recurrent abscess formation (HP:0002722)2.96571812
10Vertebral compression fractures (HP:0002953)2.88622245
11Recurrent bacterial skin infections (HP:0005406)2.75499057
12Vascular tortuosity (HP:0004948)2.74911765
13Aortic dissection (HP:0002647)2.74687563
14Increased cerebral lipofuscin (HP:0011813)2.73457320
15Cholecystitis (HP:0001082)2.72536307
16Abnormal gallbladder physiology (HP:0012438)2.72536307
17Follicular hyperkeratosis (HP:0007502)2.71843237
18Arterial tortuosity (HP:0005116)2.67096861
19Hematochezia (HP:0002573)2.66025818
20Fragile skin (HP:0001030)2.60685958
21Aortic aneurysm (HP:0004942)2.58842427
22Shallow orbits (HP:0000586)2.54139321
23Myocardial infarction (HP:0001658)2.52683570
24Loss of speech (HP:0002371)2.50719461
25Osteolytic defects of the phalanges of the hand (HP:0009771)2.50624186
26Osteolytic defects of the hand bones (HP:0009699)2.50624186
27Nuclear cataract (HP:0100018)2.43179270
28Reduced subcutaneous adipose tissue (HP:0003758)2.41355614
29Metaphyseal cupping (HP:0003021)2.40890201
30Mitral valve prolapse (HP:0001634)2.40840469
31Cellulitis (HP:0100658)2.36545983
32Blue sclerae (HP:0000592)2.35418043
33Genu recurvatum (HP:0002816)2.35264575
34Dilatation of the ascending aorta (HP:0005111)2.32223929
35Ulnar bowing (HP:0003031)2.31893238
36Soft skin (HP:0000977)2.30492234
37Bladder diverticulum (HP:0000015)2.29086882
38Systemic lupus erythematosus (HP:0002725)2.28418778
39Interstitial pulmonary disease (HP:0006530)2.25782145
40Subacute progressive viral hepatitis (HP:0006572)2.25679751
41Radial bowing (HP:0002986)2.25101682
42Upper motor neuron abnormality (HP:0002127)2.23342803
43Increased neuronal autofluorescent lipopigment (HP:0002074)2.23228468
44Generalized amyotrophy (HP:0003700)2.22748661
45Hand muscle atrophy (HP:0009130)2.21056486
46Spinal rigidity (HP:0003306)2.20185861
47Amyloidosis (HP:0011034)2.18492677
48Elbow flexion contracture (HP:0002987)2.17966261
49Abnormality of the acetabulum (HP:0003170)2.16793275
50Vacuolated lymphocytes (HP:0001922)2.16073123
51Thrombocytosis (HP:0001894)2.15652268
52Beaking of vertebral bodies (HP:0004568)2.11390028
53Short nail (HP:0001799)2.10132069
54Broad metatarsal (HP:0001783)2.08976197
55Natal tooth (HP:0000695)2.08068336
56Abnormality of the umbilical cord (HP:0010881)2.08059883
57Spondylolisthesis (HP:0003302)2.07523615
58Abnormality of dentin (HP:0010299)2.06260956
59Mucopolysacchariduria (HP:0008155)2.05889502
60Urinary glycosaminoglycan excretion (HP:0003541)2.05889502
61Abnormality of the lumbar spine (HP:0100712)2.05131156
62Wormian bones (HP:0002645)2.04595030
63Aneurysm (HP:0002617)2.03594264
64Abnormality of the distal phalanges of the toes (HP:0010182)2.03583736
65Upper limb amyotrophy (HP:0009129)2.03130681
66Distal upper limb amyotrophy (HP:0007149)2.03130681
67Atrophic scars (HP:0001075)2.02292559
68Thoracic kyphosis (HP:0002942)2.01833351
69Biconcave vertebral bodies (HP:0004586)2.00683949
70Dysostosis multiplex (HP:0000943)2.00589984
71Rough bone trabeculation (HP:0100670)1.99785075
72Coxa vara (HP:0002812)1.98703289
73Abnormality of the peritoneum (HP:0002585)1.98500486
74Abnormality of macrophages (HP:0004311)1.98255697
75Entropion (HP:0000621)1.98011050
76Glomerulonephritis (HP:0000099)1.97028878
77Increased density of long bones (HP:0006392)1.96675056
78Autoimmune thrombocytopenia (HP:0001973)1.96134695
79Mediastinal lymphadenopathy (HP:0100721)1.95742312
80Flat acetabular roof (HP:0003180)1.95062502
81Distal lower limb muscle weakness (HP:0009053)1.94902431
82Bowed forearm bones (HP:0003956)1.93650041
83Bowing of the arm (HP:0006488)1.93650041
84Abnormality of the thoracic spine (HP:0100711)1.92132559
85Cupped ribs (HP:0000887)1.91659453
86Elevated erythrocyte sedimentation rate (HP:0003565)1.91221234
87Increased connective tissue (HP:0009025)1.91034576
88Trismus (HP:0000211)1.90610230
89Hepatosplenomegaly (HP:0001433)1.89553806
90Spontaneous hematomas (HP:0007420)1.88906593
91Abnormal delivery (HP:0001787)1.88381214
92Platyspondyly (HP:0000926)1.87772078
93Abnormality of glycosaminoglycan metabolism (HP:0004371)1.85975768
94Abnormality of mucopolysaccharide metabolism (HP:0011020)1.85975768
95Abnormality of polysaccharide metabolism (HP:0011012)1.85975768
96Joint stiffness (HP:0001387)1.84915123
97Bilateral sensorineural hearing impairment (HP:0008619)1.84262304
98Lymphangioma (HP:0100764)1.83933392
99Abnormality of the calcaneus (HP:0008364)1.83905696
100Achilles tendon contracture (HP:0001771)1.83674977
101Ectopia lentis (HP:0001083)1.82600335
102Disinhibition (HP:0000734)1.82238404
103Delayed cranial suture closure (HP:0000270)1.81019292
104Thin bony cortex (HP:0002753)1.80250475
105Myositis (HP:0100614)1.79697703
106Abnormal platelet volume (HP:0011876)1.79296728
107Epiphyseal dysplasia (HP:0002656)1.78920535
108Increased mean platelet volume (HP:0011877)1.77842051
109Gingivitis (HP:0000230)1.77827697
110Nephritis (HP:0000123)1.77306707
111Slender build (HP:0001533)1.76803964
112Absent frontal sinuses (HP:0002688)1.76330198
113Mitral stenosis (HP:0001718)1.75999761
114Nonimmune hydrops fetalis (HP:0001790)1.75901308
115Periodontitis (HP:0000704)1.75856461
116Ovoid vertebral bodies (HP:0003300)1.75489692
117Osteomyelitis (HP:0002754)1.75455970
118Hyperacusis (HP:0010780)1.73536982
119Tetraparesis (HP:0002273)1.72566662
120Abnormality of carpal bone ossification (HP:0006257)1.71965783
121Cutaneous melanoma (HP:0012056)1.71833420
122Abnormality of complement system (HP:0005339)1.71745767
123Hypokinesia (HP:0002375)1.71388800
124Wrist flexion contracture (HP:0001239)1.71216894
125Deep venous thrombosis (HP:0002625)1.70884216
126Albinism (HP:0001022)1.69776557
127Abnormal trabecular bone morphology (HP:0100671)1.69751542
128Joint laxity (HP:0001388)1.68624524
129Disproportionate tall stature (HP:0001519)1.68284014
130Pustule (HP:0200039)1.68147552
131Syringomyelia (HP:0003396)1.68121778
132Spinal cord lesions (HP:0100561)1.68121778
133Abnormalities of placenta or umbilical cord (HP:0001194)1.67867331
134Exostoses (HP:0100777)1.67522303
135Esophageal varix (HP:0002040)1.67481402
136Abnormality of glycolipid metabolism (HP:0010969)1.67362816
137Abnormality of liposaccharide metabolism (HP:0010968)1.67362816
138Abnormality of glycosphingolipid metabolism (HP:0004343)1.67362816
139Axonal loss (HP:0003447)1.66501344
140Delayed closure of the anterior fontanelle (HP:0001476)1.64618933
141Thick nail (HP:0001805)1.64512805
142Alopecia of scalp (HP:0002293)1.64304508
143Abnormal umbilical cord blood vessels (HP:0011403)1.63825752
144Single umbilical artery (HP:0001195)1.63825752
145Abnormality of the fetal cardiovascular system (HP:0010948)1.63825752
146Broad face (HP:0000283)1.62343819
147Fatigue (HP:0012378)1.62233810
148Abnormality of the Achilles tendon (HP:0005109)1.61556407
149Prolonged neonatal jaundice (HP:0006579)1.60700688
150White forelock (HP:0002211)1.60319220
151Abnormality of glycolysis (HP:0004366)1.60164043
152J-shaped sella turcica (HP:0002680)1.59835206
153Orthostatic hypotension (HP:0001278)1.59465630

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.23695155
2ERN13.54331432
3PKN23.48138088
4MAP3K102.94802736
5MST1R2.63543912
6SMG12.43893355
7TTN2.42651533
8EEF2K2.35179502
9SIK32.30985518
10MAP4K12.08907813
11EIF2AK12.04716379
12RIPK12.02706545
13TGFBR21.98215943
14FLT31.97554911
15PAK41.88161476
16LIMK11.87963927
17LRRK21.86549139
18PIM21.84307004
19PDK21.79981654
20PBK1.79640426
21CDK121.75526698
22KIT1.73840614
23TBK11.72790001
24PTK61.71097049
25SCYL21.71039581
26BUB11.70699971
27STK101.69929548
28TYK21.64003596
29DDR21.50497035
30SIK11.49767113
31BLK1.48717696
32MAP2K31.48377896
33ICK1.46683982
34RPS6KA41.45254418
35MET1.42153735
36BMX1.41708843
37NME21.39868648
38TGFBR11.38929228
39CSF1R1.35192763
40EPHA21.34064985
41PDGFRA1.30189985
42NEK91.27640814
43JAK31.27390037
44NEK11.24087985
45MOS1.22035533
46CDK61.19866554
47MAP3K141.19133833
48ERBB41.15305610
49MAP3K31.14820971
50EIF2AK31.14110361
51VRK21.13174173
52PIM11.12090632
53EPHB21.11845080
54ZAP701.05429900
55CSK1.04289908
56PRPF4B1.03741377
57TRIM281.03602276
58CAMK1D1.01153404
59BTK1.00092949
60BRSK10.99715107
61CDK40.99486914
62FER0.98839662
63NEK20.95300422
64PAK20.94937296
65ARAF0.94629899
66MYLK0.94001470
67RPS6KB20.93023582
68MAP3K80.91481733
69RIPK40.91144035
70MATK0.90936580
71FGFR40.87626199
72STK30.87158850
73MAP3K110.85119532
74CDC42BPA0.84695581
75MARK30.83263555
76IKBKB0.82975182
77JAK10.82737362
78CLK10.82447798
79LMTK20.79459807
80EPHB10.76554760
81TRPM70.76147318
82MTOR0.75536867
83CHUK0.74523193
84HCK0.73983035
85TIE10.72529871
86KDR0.71908747
87LATS10.70744552
88LATS20.70022780
89TESK10.68854408
90MAP3K130.68354860
91PTK20.66827704
92GSK3A0.65651446
93IRAK40.65315375
94NTRK10.62286890
95MELK0.61752653
96ILK0.61564415
97MAP3K120.60891148
98CDK70.60041857
99STK40.60035052
100GRK60.59203740
101PAK10.57971926
102ABL20.57137739
103JAK20.54218573
104FGR0.53837365
105PRKCI0.53026331
106TAOK20.51463474
107PRKD20.51023836
108DYRK1B0.49967520
109SYK0.48922906
110EGFR0.48875242
111TEC0.48434884
112RPS6KA60.48310394
113PDGFRB0.47775947
114ROCK20.47687350
115IRAK30.47669293
116LYN0.47204793
117DAPK10.46824254
118MAP2K20.45293165
119ABL10.45277372
120MAPKAPK30.45111490
121WEE10.44859694
122PRKD30.44793445
123BRAF0.43755523
124ALK0.43290108
125RPS6KC10.43078610
126RPS6KL10.43078610
127FGFR30.42589434
128CDK80.42555648
129KSR10.42109732
130TSSK60.40300148
131PDPK10.40054023
132PRKG20.40013669
133MAPK110.39979703
134LCK0.39854745
135PASK0.39722723
136IKBKE0.39560105
137MAPKAPK20.38729265
138DAPK30.38715961
139TAOK30.38699527
140ROCK10.38374923
141ACVR1B0.38066545
142MAP2K10.37818507
143BRSK20.37523443
144ERBB30.37359081
145RAF10.36112932
146TESK20.34194290
147RPS6KA20.33896426

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.33588441
2Proteasome_Homo sapiens_hsa030502.10393698
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.10264668
4Staphylococcus aureus infection_Homo sapiens_hsa051502.07438320
5ECM-receptor interaction_Homo sapiens_hsa045121.87453215
6Legionellosis_Homo sapiens_hsa051341.84495315
7Glycosaminoglycan degradation_Homo sapiens_hsa005311.79854169
8Osteoclast differentiation_Homo sapiens_hsa043801.79031589
9Lysosome_Homo sapiens_hsa041421.71988358
10Complement and coagulation cascades_Homo sapiens_hsa046101.71485567
11Malaria_Homo sapiens_hsa051441.70326838
12Small cell lung cancer_Homo sapiens_hsa052221.70265861
13Antigen processing and presentation_Homo sapiens_hsa046121.63844159
14B cell receptor signaling pathway_Homo sapiens_hsa046621.58597388
15Toxoplasmosis_Homo sapiens_hsa051451.58016747
16Chronic myeloid leukemia_Homo sapiens_hsa052201.57288834
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.56880182
18Fructose and mannose metabolism_Homo sapiens_hsa000511.53980824
19Amoebiasis_Homo sapiens_hsa051461.52690543
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.49370949
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.48336221
22Tuberculosis_Homo sapiens_hsa051521.47216570
23Other glycan degradation_Homo sapiens_hsa005111.46554964
24Focal adhesion_Homo sapiens_hsa045101.45852887
25Pertussis_Homo sapiens_hsa051331.43094214
26Apoptosis_Homo sapiens_hsa042101.41273026
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.40487848
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.35339132
29One carbon pool by folate_Homo sapiens_hsa006701.33231669
30Vibrio cholerae infection_Homo sapiens_hsa051101.31181124
31DNA replication_Homo sapiens_hsa030301.29375979
32Shigellosis_Homo sapiens_hsa051311.28330564
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.27777134
34Proteoglycans in cancer_Homo sapiens_hsa052051.27651487
35TNF signaling pathway_Homo sapiens_hsa046681.22591412
36Bladder cancer_Homo sapiens_hsa052191.21106847
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17238830
38Acute myeloid leukemia_Homo sapiens_hsa052211.15857117
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13395146
40Sphingolipid metabolism_Homo sapiens_hsa006001.11585916
41Hepatitis B_Homo sapiens_hsa051611.10661072
42Measles_Homo sapiens_hsa051621.09096007
43Viral myocarditis_Homo sapiens_hsa054161.08003194
44Viral carcinogenesis_Homo sapiens_hsa052031.07798896
45Vitamin B6 metabolism_Homo sapiens_hsa007501.07756833
46Phagosome_Homo sapiens_hsa041451.06758921
47Pancreatic cancer_Homo sapiens_hsa052121.03919733
48Hematopoietic cell lineage_Homo sapiens_hsa046401.03269028
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03013541
50Non-homologous end-joining_Homo sapiens_hsa034501.02329397
51Herpes simplex infection_Homo sapiens_hsa051680.99646034
52Glutathione metabolism_Homo sapiens_hsa004800.99366859
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98688195
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98069523
55Influenza A_Homo sapiens_hsa051640.97393435
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96513904
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.94921707
58Adherens junction_Homo sapiens_hsa045200.93973642
59Fatty acid elongation_Homo sapiens_hsa000620.93957884
60Sulfur metabolism_Homo sapiens_hsa009200.93576511
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93556626
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90863116
63Prion diseases_Homo sapiens_hsa050200.90647424
64Salmonella infection_Homo sapiens_hsa051320.89766356
65Platelet activation_Homo sapiens_hsa046110.89463478
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88432261
67Carbon metabolism_Homo sapiens_hsa012000.88152573
68Pyrimidine metabolism_Homo sapiens_hsa002400.87613505
69MicroRNAs in cancer_Homo sapiens_hsa052060.86887542
70Pentose phosphate pathway_Homo sapiens_hsa000300.86214772
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85715606
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.85418118
73p53 signaling pathway_Homo sapiens_hsa041150.84960787
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83246208
75Caffeine metabolism_Homo sapiens_hsa002320.83182553
76HIF-1 signaling pathway_Homo sapiens_hsa040660.82267297
77HTLV-I infection_Homo sapiens_hsa051660.81698875
78N-Glycan biosynthesis_Homo sapiens_hsa005100.81375575
79* Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78978408
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.78807002
81Base excision repair_Homo sapiens_hsa034100.78467723
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78068529
83Nitrogen metabolism_Homo sapiens_hsa009100.77356976
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77267389
85Insulin resistance_Homo sapiens_hsa049310.76288887
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.74908177
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74700027
88Selenocompound metabolism_Homo sapiens_hsa004500.73937168
89Thyroid cancer_Homo sapiens_hsa052160.70840872
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70584239
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.69769556
92Notch signaling pathway_Homo sapiens_hsa043300.67742924
93TGF-beta signaling pathway_Homo sapiens_hsa043500.67310241
94Galactose metabolism_Homo sapiens_hsa000520.66512599
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66033705
96Rheumatoid arthritis_Homo sapiens_hsa053230.65463369
97mTOR signaling pathway_Homo sapiens_hsa041500.64783745
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.64773093
99Non-small cell lung cancer_Homo sapiens_hsa052230.63980977
100Sulfur relay system_Homo sapiens_hsa041220.62924163
101Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62677782
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62215943
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62145875
104Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61688355
105Colorectal cancer_Homo sapiens_hsa052100.60876960
106Endocytosis_Homo sapiens_hsa041440.60331786
1072-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60284560
108Protein digestion and absorption_Homo sapiens_hsa049740.58501967
109Nucleotide excision repair_Homo sapiens_hsa034200.58489178
110Epstein-Barr virus infection_Homo sapiens_hsa051690.58250266
111Systemic lupus erythematosus_Homo sapiens_hsa053220.57957797
112Biosynthesis of amino acids_Homo sapiens_hsa012300.57409796
113Cell cycle_Homo sapiens_hsa041100.56256256
114* Lysine degradation_Homo sapiens_hsa003100.56001064
115PPAR signaling pathway_Homo sapiens_hsa033200.55702150
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55492771
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55323979
118Renin-angiotensin system_Homo sapiens_hsa046140.52990741
119Steroid biosynthesis_Homo sapiens_hsa001000.52986759
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52691796
121Arginine biosynthesis_Homo sapiens_hsa002200.51699406
122Prostate cancer_Homo sapiens_hsa052150.48242164
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47445290
124Mismatch repair_Homo sapiens_hsa034300.46675283
125RNA transport_Homo sapiens_hsa030130.42958157
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40967897
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.40147326
128Melanoma_Homo sapiens_hsa052180.39489476
129VEGF signaling pathway_Homo sapiens_hsa043700.38288988
130Hepatitis C_Homo sapiens_hsa051600.37943771
131Cyanoamino acid metabolism_Homo sapiens_hsa004600.36796953

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