COLQ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the subunit of a collagen-like molecule associated with acetylcholinesterase in skeletal muscle. Each molecule is composed of three identical subunits. Each subunit contains a proline-rich attachment domain (PRAD) that binds an acetylcholinesterase tetramer to anchor the catalytic subunit of the enzyme to the basal lamina. Mutations in this gene are associated with endplate acetylcholinesterase deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous antigen (GO:0019883)6.98593363
2positive regulation of gamma-delta T cell activation (GO:0046645)6.77218325
3regulation of gamma-delta T cell differentiation (GO:0045586)6.58573801
4V(D)J recombination (GO:0033151)6.33860978
5regulation of gamma-delta T cell activation (GO:0046643)6.24161167
6positive T cell selection (GO:0043368)6.00048690
7NIK/NF-kappaB signaling (GO:0038061)5.87314940
8negative T cell selection (GO:0043383)5.77685778
9oxygen transport (GO:0015671)5.29501826
10bundle of His cell to Purkinje myocyte communication (GO:0086069)5.26848760
11positive thymic T cell selection (GO:0045059)5.24128069
12sarcoplasmic reticulum calcium ion transport (GO:0070296)5.23245262
13regulation of dendritic cell antigen processing and presentation (GO:0002604)5.19979179
14T cell selection (GO:0045058)5.07991190
15negative regulation of thymocyte apoptotic process (GO:0070244)4.96863173
16negative thymic T cell selection (GO:0045060)4.75987463
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.74952998
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.74952998
19positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.68347817
20mucosal-associated lymphoid tissue development (GO:0048537)4.65918509
21Peyers patch development (GO:0048541)4.65918509
22positive regulation of natural killer cell differentiation (GO:0032825)4.64882294
23regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.50157455
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.47450063
25negative regulation of cell killing (GO:0031342)4.47450063
26positive regulation of antigen processing and presentation (GO:0002579)4.45352483
27positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.44595053
28sarcomere organization (GO:0045214)4.35021023
29thymic T cell selection (GO:0045061)4.30794509
30actin-myosin filament sliding (GO:0033275)4.22921998
31muscle filament sliding (GO:0030049)4.22921998
32cardiac muscle hypertrophy (GO:0003300)4.22415362
33regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.15766162
34striated muscle hypertrophy (GO:0014897)4.02867378
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.01159147
36regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.90437367
37cellular extravasation (GO:0045123)3.84349403
38muscle hypertrophy (GO:0014896)3.79832293
39negative regulation of necroptotic process (GO:0060546)3.78052671
40positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.71787349
41regulation of antigen processing and presentation (GO:0002577)3.71681205
42regulation of natural killer cell differentiation (GO:0032823)3.65933238
43positive regulation of granulocyte chemotaxis (GO:0071624)3.59766675
44positive regulation of interleukin-2 production (GO:0032743)3.58704276
45positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.48137206
46myofibril assembly (GO:0030239)3.47179961
47adult heart development (GO:0007512)3.46519590
48cardiac myofibril assembly (GO:0055003)3.45280712
49T cell homeostasis (GO:0043029)3.42754910
50actin-mediated cell contraction (GO:0070252)3.40682150
51T cell receptor signaling pathway (GO:0050852)3.37593179
52myeloid dendritic cell differentiation (GO:0043011)3.34740391
53ventricular cardiac muscle cell action potential (GO:0086005)3.33190783
54regulation of B cell receptor signaling pathway (GO:0050855)3.32729736
55positive regulation of DNA-templated transcription, initiation (GO:2000144)3.31878212
56natural killer cell differentiation (GO:0001779)3.29182534
57skeletal muscle adaptation (GO:0043501)3.27844668
58regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.25921168
59striated muscle atrophy (GO:0014891)3.24016000
60regulation of T-helper 1 cell differentiation (GO:0045625)3.23427092
61regulation of thymocyte apoptotic process (GO:0070243)3.22820496
62histone H3-K4 trimethylation (GO:0080182)3.22345029
63T cell costimulation (GO:0031295)3.21657701
64cardiac muscle cell development (GO:0055013)3.19187493
65regulation of necroptotic process (GO:0060544)3.18412844
66lymphocyte costimulation (GO:0031294)3.16772573
67regulation of relaxation of muscle (GO:1901077)3.16658217
68myeloid dendritic cell activation (GO:0001773)3.14980646
69negative regulation of T cell apoptotic process (GO:0070233)3.14250293
70regulation of the force of heart contraction (GO:0002026)3.12675086
71response to caffeine (GO:0031000)3.11860032
72regulation of striated muscle contraction (GO:0006942)3.11856163
73response to interleukin-15 (GO:0070672)3.11480117
74T cell differentiation (GO:0030217)3.10652970
75negative regulation of necrotic cell death (GO:0060547)3.08572432
76cardiac muscle adaptation (GO:0014887)3.08105067
77cardiac muscle hypertrophy in response to stress (GO:0014898)3.08105067
78muscle hypertrophy in response to stress (GO:0003299)3.08105067
79negative regulation of leukocyte apoptotic process (GO:2000107)3.07784167
80neutrophil activation involved in immune response (GO:0002283)3.07725015
81JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.07022526
82striated muscle adaptation (GO:0014888)3.06639659
83cardiac cell development (GO:0055006)3.05230830
84activated T cell proliferation (GO:0050798)3.04507967
85cardiac muscle contraction (GO:0060048)3.03099852
86cardiac chamber formation (GO:0003207)3.02105594
87negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.01789390
88antigen receptor-mediated signaling pathway (GO:0050851)3.01755596
89substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.01284570
90substrate-independent telencephalic tangential migration (GO:0021826)3.01284570
91regulation of skeletal muscle contraction (GO:0014819)2.98036695
92positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.97774590
93regulation of RIG-I signaling pathway (GO:0039535)2.97597140
94lymphocyte homeostasis (GO:0002260)2.96711540
95striated muscle contraction (GO:0006941)2.96198510
96pericardium development (GO:0060039)2.95962691
97gas transport (GO:0015669)2.95907170
98negative regulation of lymphocyte apoptotic process (GO:0070229)2.93252355
99muscle atrophy (GO:0014889)2.93091871
100antigen processing and presentation via MHC class Ib (GO:0002475)2.92845299
101relaxation of cardiac muscle (GO:0055119)2.91768834
102skeletal muscle contraction (GO:0003009)2.91663527
103alpha-beta T cell differentiation (GO:0046632)2.90395989
104regulation of interleukin-2 biosynthetic process (GO:0045076)2.89858477
105cellular response to zinc ion (GO:0071294)2.89840187
106positive regulation of granulocyte differentiation (GO:0030854)2.88895091
107creatine metabolic process (GO:0006600)2.88317700
108cardiac ventricle formation (GO:0003211)2.88091196
109positive regulation of T cell differentiation (GO:0045582)2.88024623
110muscle contraction (GO:0006936)2.85815270
111positive regulation of T-helper cell differentiation (GO:0045624)2.85366800
112tachykinin receptor signaling pathway (GO:0007217)2.84970740
113actomyosin structure organization (GO:0031032)2.84491598
114regulation of T cell differentiation (GO:0045580)2.84023954
115positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.80345552
116alpha-beta T cell activation (GO:0046631)2.79455629
117response to inactivity (GO:0014854)2.79135903
118T cell proliferation (GO:0042098)2.79024758
119cellular hyperosmotic response (GO:0071474)2.77111767
120muscle tissue morphogenesis (GO:0060415)2.75478497
121response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.74910085
122membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.74859216
123actin filament-based movement (GO:0030048)2.74855369
124T cell differentiation in thymus (GO:0033077)2.74797137
125muscle system process (GO:0003012)2.74602722
126modulation by symbiont of host cellular process (GO:0044068)2.74060347
127regulation of skeletal muscle cell differentiation (GO:2001014)2.73706193
128negative regulation of potassium ion transmembrane transport (GO:1901380)2.73490946
129cellular response to epinephrine stimulus (GO:0071872)2.72350255
130T cell migration (GO:0072678)2.71924278
131regulation of interleukin-2 production (GO:0032663)2.71534407
132negative regulation of myotube differentiation (GO:0010832)2.71377874
133carnitine shuttle (GO:0006853)2.69745171
134somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.68895335
135somatic cell DNA recombination (GO:0016444)2.68895335
136regulation of actin filament-based movement (GO:1903115)2.68556435
137cardiac muscle tissue morphogenesis (GO:0055008)2.67952813
138negative regulation of lymphocyte mediated immunity (GO:0002707)2.67907918
139desmosome organization (GO:0002934)2.66301008
140regulation of germinal center formation (GO:0002634)2.65334087
141positive regulation of lymphocyte differentiation (GO:0045621)2.65177679
142dendritic cell differentiation (GO:0097028)2.64577069
143regulation of calcium ion transmembrane transporter activity (GO:1901019)2.64318202
144regulation of calcium ion transmembrane transport (GO:1903169)2.64318202
145germinal center formation (GO:0002467)2.62282394
146cellular response to interleukin-15 (GO:0071350)2.59136786
147positive regulation of myotube differentiation (GO:0010831)2.57734169
148regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.57229809
149leukocyte aggregation (GO:0070486)2.56940197
150muscle adaptation (GO:0043500)2.56446600
151response to epinephrine (GO:0071871)2.55077432
152relaxation of muscle (GO:0090075)2.53606308
153regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.51542136
154cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.49400197
155megakaryocyte development (GO:0035855)2.46980413
156negative regulation of erythrocyte differentiation (GO:0045647)2.46250651
157negative regulation of T cell mediated immunity (GO:0002710)2.41403233
158regulation of cardiac muscle contraction (GO:0055117)2.40203357
159positive regulation of myoblast differentiation (GO:0045663)2.38659291
160B cell receptor signaling pathway (GO:0050853)2.38266550
161positive regulation of cation channel activity (GO:2001259)2.36372871

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.74858285
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.07611533
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.79352492
4MYC_22102868_ChIP-Seq_BL_Human3.50587633
5RUNX_20019798_ChIP-Seq_JUKART_Human3.08305324
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.94801424
7FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.74415426
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.68491154
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.62309082
10VDR_21846776_ChIP-Seq_THP-1_Human2.57394298
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.57194029
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.56715486
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.50589284
14* MYB_26560356_Chip-Seq_TH2_Human2.43988648
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.43252156
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.25778953
17TCF7_22412390_ChIP-Seq_EML_Mouse2.18365140
18* TBX20_22328084_ChIP-Seq_HEART_Mouse2.07329528
19* TBX20_22080862_ChIP-Seq_HEART_Mouse2.07329528
20UTX_26944678_Chip-Seq_JUKART_Human2.04563128
21KDM2B_26808549_Chip-Seq_SUP-B15_Human2.03815746
22MAF_26560356_Chip-Seq_TH1_Human1.99608910
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.85665781
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.81362165
25VDR_24763502_ChIP-Seq_THP-1_Human1.80653550
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.80429573
27KDM2B_26808549_Chip-Seq_DND41_Human1.75390086
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.72347724
29MYB_26560356_Chip-Seq_TH1_Human1.70351409
30GATA3_27048872_Chip-Seq_THYMUS_Human1.69016230
31CIITA_25753668_ChIP-Seq_RAJI_Human1.68941357
32STAT4_19710469_ChIP-ChIP_TH1__Mouse1.67313444
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.65031143
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.64706169
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.60732249
36EP300_21415370_ChIP-Seq_HL-1_Mouse1.55343674
37KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54787480
38* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.51151276
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50005807
40* SPI1_23127762_ChIP-Seq_K562_Human1.47112598
41* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44688342
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42840423
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.38149439
44DROSHA_22980978_ChIP-Seq_HELA_Human1.37581435
45SCL_19346495_ChIP-Seq_HPC-7_Human1.35316087
46VDR_24787735_ChIP-Seq_THP-1_Human1.35158151
47IRF8_27001747_Chip-Seq_BMDM_Mouse1.34510026
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29211316
49RUNX1_27514584_Chip-Seq_MCF-7_Human1.29045515
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.27143964
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.26450614
52* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24826737
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24547360
54E2F7_22180533_ChIP-Seq_HELA_Human1.21818821
55TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.18963832
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17443475
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.16149600
58AR_21572438_ChIP-Seq_LNCaP_Human1.15252627
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14536790
60* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13482367
61GATA2_19941826_ChIP-Seq_K562_Human1.13348924
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11407866
63SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10937129
64TCF4_18268006_ChIP-ChIP_LS174T_Human1.09828427
65ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09507256
66CLOCK_20551151_ChIP-Seq_293T_Human1.09192660
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09000015
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08214940
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08107247
70GATA1_22025678_ChIP-Seq_K562_Human1.07486256
71NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06925397
72NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04847960
73TRIM28_21343339_ChIP-Seq_HEK293_Human1.00816943
74EZH2_27294783_Chip-Seq_ESCs_Mouse1.00604897
75PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99953106
76LXR_22292898_ChIP-Seq_THP-1_Human0.99700328
77* GATA1_19941827_ChIP-Seq_MEL_Mouse0.99458076
78PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.98439788
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98393533
80BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97988988
81TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97298073
82RUNX1_22412390_ChIP-Seq_EML_Mouse0.96862703
83BCAT_22108803_ChIP-Seq_LS180_Human0.96714387
84KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.95599829
85SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95418877
86CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94927980
87GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94812776
88WDR5_24793694_ChIP-Seq_LNCAP_Human0.94245221
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91527612
90FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.90838133
91GATA1_19941827_ChIP-Seq_MEL86_Mouse0.90754036
92OCT4_19829295_ChIP-Seq_ESCs_Human0.90625068
93IRF8_21731497_ChIP-ChIP_J774_Mouse0.90229752
94* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89506714
95RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89368767
96BCL6_27268052_Chip-Seq_Bcells_Human0.88704670
97EZH2_22144423_ChIP-Seq_EOC_Human0.88325180
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87766717
99* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.87542922
100* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86596476
101RARB_27405468_Chip-Seq_BRAIN_Mouse0.86018919
102NOTCH1_21737748_ChIP-Seq_TLL_Human0.85353569
103SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85248493
104SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85140726
105GATA1_19941826_ChIP-Seq_K562_Human0.84969231
106ESR2_21235772_ChIP-Seq_MCF-7_Human0.84921980
107* SMRT_27268052_Chip-Seq_Bcells_Human0.84806817
108MAF_26560356_Chip-Seq_TH2_Human0.83415885
109BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.83087966
110PU_27001747_Chip-Seq_BMDM_Mouse0.82962534
111FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82840134
112ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82828494
113VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.82529636
114CTCF_27219007_Chip-Seq_Bcells_Human0.82441431
115EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.82320225
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81426466
117SUZ12_27294783_Chip-Seq_ESCs_Mouse0.80964325
118ELK4_26923725_Chip-Seq_MESODERM_Mouse0.80341470
119SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.79446246
120OCT4_20526341_ChIP-Seq_ESCs_Human0.79256331
121EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.79150159
122KDM2B_26808549_Chip-Seq_JURKAT_Human0.79138884
123RACK7_27058665_Chip-Seq_MCF-7_Human0.78807508
124PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78477124
125* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.78335444
126DNAJC2_21179169_ChIP-ChIP_NT2_Human0.78283303
127SPI1_23547873_ChIP-Seq_NB4_Human0.78037618
128AHR_22903824_ChIP-Seq_MCF-7_Human0.77585837
129P68_20966046_ChIP-Seq_HELA_Human0.77282625
130MYB_21317192_ChIP-Seq_ERMYB_Mouse0.77241364
131P63_26484246_Chip-Seq_KERATINOCYTES_Human0.77204314
132SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.76941279
133* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.76203236
134CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76137664
135SMC4_20622854_ChIP-Seq_HELA_Human0.75838921
136MYC_27129775_Chip-Seq_CORNEA_Mouse0.75227270
137SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.74962275
138NFIB_24661679_ChIP-Seq_LUNG_Mouse0.74816116
139SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73779902
140SPI1_20517297_ChIP-Seq_HL60_Human0.73648931

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat7.64170483
2MP0000685_abnormal_immune_system4.76141288
3MP0004510_myositis3.90744942
4MP0002876_abnormal_thyroid_physiology3.68648218
5MP0003763_abnormal_thymus_physiology3.44249594
6MP0001348_abnormal_lacrimal_gland3.34619708
7MP0001346_abnormal_lacrimal_gland3.14678869
8MP0001873_stomach_inflammation3.13604508
9MP0001835_abnormal_antigen_presentation3.04444044
10MP0005310_abnormal_salivary_gland2.83829722
11MP0005645_abnormal_hypothalamus_physiol2.65401553
12MP0005671_abnormal_response_to2.55334701
13MP0003879_abnormal_hair_cell2.48949757
14MP0003436_decreased_susceptibility_to2.41038632
15MP0002837_dystrophic_cardiac_calcinosis2.34132281
16MP0005387_immune_system_phenotype2.23063348
17MP0001790_abnormal_immune_system2.23063348
18MP0006082_CNS_inflammation2.13596276
19MP0000751_myopathy2.07851946
20MP0000703_abnormal_thymus_morphology2.05746286
21MP0003303_peritoneal_inflammation2.03192772
22MP0003646_muscle_fatigue2.01685812
23MP0004084_abnormal_cardiac_muscle1.97167790
24MP0000013_abnormal_adipose_tissue1.91366758
25MP0002332_abnormal_exercise_endurance1.86872604
26MP0002166_altered_tumor_susceptibility1.79404992
27MP0004036_abnormal_muscle_relaxation1.74021202
28MP0001800_abnormal_humoral_immune1.71461616
29MP0005330_cardiomyopathy1.67836974
30MP0003828_pulmonary_edema1.63508725
31MP0000749_muscle_degeneration1.62557281
32MP0002106_abnormal_muscle_physiology1.54970673
33MP0003656_abnormal_erythrocyte_physiolo1.49285944
34MP0003172_abnormal_lysosome_physiology1.48075506
35MP0002398_abnormal_bone_marrow1.46044360
36MP0004087_abnormal_muscle_fiber1.45567767
37MP0004215_abnormal_myocardial_fiber1.45559068
38MP0005464_abnormal_platelet_physiology1.44343472
39MP0003787_abnormal_imprinting1.42709686
40MP0009785_altered_susceptibility_to1.42471586
41MP0002405_respiratory_system_inflammati1.39878991
42MP0010155_abnormal_intestine_physiology1.37892925
43MP0005451_abnormal_body_composition1.36774149
44MP0002972_abnormal_cardiac_muscle1.33540720
45MP0000716_abnormal_immune_system1.33057016
46MP0001986_abnormal_taste_sensitivity1.32431626
47MP0002006_tumorigenesis1.30195110
48MP0001545_abnormal_hematopoietic_system1.29518698
49MP0005000_abnormal_immune_tolerance1.27544281
50MP0001849_ear_inflammation1.25850941
51MP0009278_abnormal_bone_marrow1.24916551
52MP0002722_abnormal_immune_system1.24341875
53MP0002420_abnormal_adaptive_immunity1.23534726
54MP0001853_heart_inflammation1.23210243
55MP0002138_abnormal_hepatobiliary_system1.22680170
56MP0001819_abnormal_immune_cell1.22465352
57MP0002877_abnormal_melanocyte_morpholog1.22451887
58MP0004947_skin_inflammation1.20988622
59MP0004484_altered_response_of1.20515130
60MP0005369_muscle_phenotype1.20418409
61MP0005620_abnormal_muscle_contractility1.19332792
62MP0008004_abnormal_stomach_pH1.18571940
63MP0002452_abnormal_antigen_presenting1.17937848
64MP0001544_abnormal_cardiovascular_syste1.16809972
65MP0005385_cardiovascular_system_phenoty1.16809972
66MP0004233_abnormal_muscle_weight1.15605597
67MP0002723_abnormal_immune_serum1.15314960
68MP0009333_abnormal_splenocyte_physiolog1.12817500
69MP0002132_abnormal_respiratory_system1.12623481
70MP0000383_abnormal_hair_follicle1.10479044
71MP0010630_abnormal_cardiac_muscle1.09953020
72MP0001533_abnormal_skeleton_physiology1.09599474
73MP0002396_abnormal_hematopoietic_system1.08146033
74MP0003045_fibrosis1.06137206
75MP0006138_congestive_heart_failure1.01778874
76MP0002429_abnormal_blood_cell1.01260957
77MP0005025_abnormal_response_to1.00356692
78MP0001851_eye_inflammation0.99424322
79MP0004859_abnormal_synaptic_plasticity0.94274765
80MP0000750_abnormal_muscle_regeneration0.93991446
81MP0002148_abnormal_hypersensitivity_rea0.93855829
82MP0003137_abnormal_impulse_conducting0.92479553
83MP0000759_abnormal_skeletal_muscle0.91469386
84MP0002269_muscular_atrophy0.89417104
85MP0006035_abnormal_mitochondrial_morpho0.88326577
86MP0006036_abnormal_mitochondrial_physio0.87841796
87MP0002822_catalepsy0.87387156
88MP0004130_abnormal_muscle_cell0.87113132
89MP0008775_abnormal_heart_ventricle0.86551822
90MP0003300_gastrointestinal_ulcer0.86286056
91MP0001845_abnormal_inflammatory_respons0.85615504
92* MP0008569_lethality_at_weaning0.85509997
93MP0000733_abnormal_muscle_development0.85484124
94MP0000689_abnormal_spleen_morphology0.85264479
95MP0008260_abnormal_autophagy0.84599100
96MP0003279_aneurysm0.82358322
97MP0003221_abnormal_cardiomyocyte_apopto0.81761121
98MP0001879_abnormal_lymphatic_vessel0.77852153
99MP0004808_abnormal_hematopoietic_stem0.77833754
100MP0004145_abnormal_muscle_electrophysio0.77180722
101MP0010678_abnormal_skin_adnexa0.76447557
102MP0005647_abnormal_sex_gland0.76271664
103MP0008874_decreased_physiological_sensi0.74689272
104MP0005266_abnormal_metabolism0.74597517
105MP0004142_abnormal_muscle_tone0.74441921
106MP0000747_muscle_weakness0.74282731
107MP0002108_abnormal_muscle_morphology0.74031943
108MP0002998_abnormal_bone_remodeling0.73728409
109MP0005375_adipose_tissue_phenotype0.73402381
110MP0003690_abnormal_glial_cell0.73073593
111MP0000470_abnormal_stomach_morphology0.72667683
112MP0000230_abnormal_systemic_arterial0.71990049
113MP0000266_abnormal_heart_morphology0.68746535
114MP0005670_abnormal_white_adipose0.66683603
115MP0009764_decreased_sensitivity_to0.64450082
116MP0002933_joint_inflammation0.64261696
117MP0002128_abnormal_blood_circulation0.63520874
118MP0002127_abnormal_cardiovascular_syste0.62826205
119MP0002277_abnormal_respiratory_mucosa0.59523640
120MP0010094_abnormal_chromosome_stability0.58996776
121MP0001485_abnormal_pinna_reflex0.58038982
122MP0005367_renal/urinary_system_phenotyp0.57682344
123MP0000516_abnormal_urinary_system0.57682344
124MP0000767_abnormal_smooth_muscle0.57680179
125MP0001663_abnormal_digestive_system0.56680819
126MP0002419_abnormal_innate_immunity0.55588384
127MP0002970_abnormal_white_adipose0.55278968
128MP0004085_abnormal_heartbeat0.52153196
129MP0000613_abnormal_salivary_gland0.51384088
130MP0000003_abnormal_adipose_tissue0.51226752
131MP0003724_increased_susceptibility_to0.50864542
132MP0002693_abnormal_pancreas_physiology0.50582795
133MP0005076_abnormal_cell_differentiation0.49882981
134MP0005397_hematopoietic_system_phenotyp0.49178432

Predicted human phenotypes

RankGene SetZ-score
1Panhypogammaglobulinemia (HP:0003139)5.74778218
2Chronic mucocutaneous candidiasis (HP:0002728)5.63389887
3Recurrent cutaneous fungal infections (HP:0011370)5.63389887
4Bundle branch block (HP:0011710)5.60757296
5Abnormality of T cell number (HP:0011839)5.44585122
6T lymphocytopenia (HP:0005403)5.35674460
7Abnormality of B cell number (HP:0010975)5.27648936
8B lymphocytopenia (HP:0010976)5.27648936
9Right ventricular cardiomyopathy (HP:0011663)4.92470451
10Recurrent fungal infections (HP:0002841)4.88249251
11Eosinophilia (HP:0001880)4.73494327
12Severe combined immunodeficiency (HP:0004430)4.65871078
13Keratoconjunctivitis (HP:0001096)4.61782225
14Thyroiditis (HP:0100646)4.58579779
15Ventricular tachycardia (HP:0004756)4.49409265
16Recurrent viral infections (HP:0004429)4.08747703
17Asymmetric septal hypertrophy (HP:0001670)3.96074426
18Combined immunodeficiency (HP:0005387)3.92508025
19Granulocytopenia (HP:0001913)3.86206643
20Hypoplasia of the thymus (HP:0000778)3.85027549
21Sudden death (HP:0001699)3.84210753
22Myopathic facies (HP:0002058)3.78351429
23Hypoproteinemia (HP:0003075)3.76492930
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.73558433
25Heart block (HP:0012722)3.65933871
26Centrally nucleated skeletal muscle fibers (HP:0003687)3.60663006
27Exercise-induced muscle cramps (HP:0003710)3.58290048
28Abnormality of eosinophils (HP:0001879)3.54721472
29Aplasia/Hypoplasia of the spleen (HP:0010451)3.47719445
30Neck muscle weakness (HP:0000467)3.41411924
31Rimmed vacuoles (HP:0003805)3.39402479
32Exercise-induced myalgia (HP:0003738)3.38147887
33Muscle hypertrophy of the lower extremities (HP:0008968)3.36615479
34Type 1 muscle fiber predominance (HP:0003803)3.34349268
35Abnormal atrioventricular conduction (HP:0005150)3.30216185
36Calf muscle hypertrophy (HP:0008981)3.29730331
37Agammaglobulinemia (HP:0004432)3.26508731
38EMG: neuropathic changes (HP:0003445)3.23186048
39Abnormality of skeletal muscle fiber size (HP:0012084)3.22749497
40Abnormality of T cells (HP:0002843)3.21384084
41Asplenia (HP:0001746)3.20380193
42Muscle fiber inclusion bodies (HP:0100299)3.19673328
43Type I diabetes mellitus (HP:0100651)3.19473452
44Abnormality of the gastric mucosa (HP:0004295)3.18848998
45Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.14071197
46Increased IgE level (HP:0003212)3.13490518
47Eczematoid dermatitis (HP:0000976)3.12249496
48Areflexia of lower limbs (HP:0002522)3.11520710
49Abnormality of the fingertips (HP:0001211)3.10816091
50Increased variability in muscle fiber diameter (HP:0003557)3.09822622
51Stomatitis (HP:0010280)3.09097390
52Hypercortisolism (HP:0001578)3.05067651
53Frequent falls (HP:0002359)3.05033861
54Abnormality of the left ventricular outflow tract (HP:0011103)3.05020026
55Subaortic stenosis (HP:0001682)3.05020026
56Rhabdomyolysis (HP:0003201)3.04120138
57Distal lower limb muscle weakness (HP:0009053)3.01339867
58Nemaline bodies (HP:0003798)2.91565537
59Palpitations (HP:0001962)2.88670861
60Hyporeflexia of lower limbs (HP:0002600)2.83405589
61Abnormal EKG (HP:0003115)2.78517759
62Muscle fiber splitting (HP:0003555)2.76855362
63Lip pit (HP:0100267)2.72422275
64Abnormality of calcium-phosphate metabolism (HP:0100530)2.68533077
65Atrial fibrillation (HP:0005110)2.67373131
66Lipoatrophy (HP:0100578)2.62693739
67Verrucae (HP:0200043)2.59447674
68Papilloma (HP:0012740)2.59447674
69Recurrent skin infections (HP:0001581)2.57790620
70IgG deficiency (HP:0004315)2.57785952
71Primary atrial arrhythmia (HP:0001692)2.54617622
72EMG: myopathic abnormalities (HP:0003458)2.50081411
73Meningitis (HP:0001287)2.47949860
74Supraventricular tachycardia (HP:0004755)2.47253695
75Abnormality of the nasal mucosa (HP:0000433)2.47029125
76Abnormality of the calf musculature (HP:0001430)2.44257048
77Chest pain (HP:0100749)2.43362439
78Supraventricular arrhythmia (HP:0005115)2.40723055
79Onycholysis (HP:0001806)2.38634615
80Abnormality of proline metabolism (HP:0010907)2.36837103
81Hydroxyprolinuria (HP:0003080)2.36837103
82Chronic otitis media (HP:0000389)2.35459234
83Myotonia (HP:0002486)2.31980658
84* Generalized muscle weakness (HP:0003324)2.30128026
85Ventricular arrhythmia (HP:0004308)2.28745034
86Dilated cardiomyopathy (HP:0001644)2.28705328
87Calcaneovalgus deformity (HP:0001848)2.27567238
88Nasal polyposis (HP:0100582)2.27152535
89Leukocytosis (HP:0001974)2.26270534
90Double outlet right ventricle (HP:0001719)2.25957606
91Congenital malformation of the right heart (HP:0011723)2.25957606
92Gastrointestinal infarctions (HP:0005244)2.25314537
93Inflammation of the large intestine (HP:0002037)2.25207106
94Keratitis (HP:0000491)2.21347071
95Colitis (HP:0002583)2.19874532
96Round ear (HP:0100830)2.17465966
97Difficulty running (HP:0009046)2.17260340
98Fetal akinesia sequence (HP:0001989)2.16195334
99Recurrent bronchitis (HP:0002837)2.15294086
100Chronic sinusitis (HP:0011109)2.13065429
101Interstitial pulmonary disease (HP:0006530)2.12302833
102Myositis (HP:0100614)2.11949995
103Gastrointestinal inflammation (HP:0004386)2.10347897
104Hip contracture (HP:0003273)2.10201513
105Prolonged QT interval (HP:0001657)2.09855183
106Bulbar palsy (HP:0001283)2.09700968
107Malignant hyperthermia (HP:0002047)2.09447903
108Milia (HP:0001056)2.09311746
109Abnormality of the endocardium (HP:0004306)2.08127192
110Toxemia of pregnancy (HP:0100603)2.07393811
111Ankle clonus (HP:0011448)2.07302645
112Muscle stiffness (HP:0003552)2.06627778
113Retrobulbar optic neuritis (HP:0100654)2.03778782
114Optic neuritis (HP:0100653)2.03778782
115Gastrointestinal stroma tumor (HP:0100723)2.01931264
116Pustule (HP:0200039)2.01869597
117Absent phalangeal crease (HP:0006109)2.01045917
118Elevated erythrocyte sedimentation rate (HP:0003565)2.00800456
119Prolonged bleeding time (HP:0003010)1.99900893
120Distal arthrogryposis (HP:0005684)1.98298753
121Distal lower limb amyotrophy (HP:0008944)1.97342747
122Spontaneous hematomas (HP:0007420)1.96195586
123Hypoparathyroidism (HP:0000829)1.95817686
124Gowers sign (HP:0003391)1.94202404
125Orchitis (HP:0100796)1.93786400
126Erythroderma (HP:0001019)1.93765114
127Cellulitis (HP:0100658)1.93456008
128Abnormality of binocular vision (HP:0011514)1.92168530
129Diplopia (HP:0000651)1.92168530
130Muscular dystrophy (HP:0003560)1.91843349
131Syncope (HP:0001279)1.91308548
132Ragged-red muscle fibers (HP:0003200)1.91295524
133Myoglobinuria (HP:0002913)1.91091327
134Truncus arteriosus (HP:0001660)1.90355501
135Mildly elevated creatine phosphokinase (HP:0008180)1.90318362
136Abnormality of the foot musculature (HP:0001436)1.87921639
137Deformed tarsal bones (HP:0008119)1.87208497
138Left ventricular hypertrophy (HP:0001712)1.86748290
139Waddling gait (HP:0002515)1.86201063
140Papilledema (HP:0001085)1.85972608
141Ventricular fibrillation (HP:0001663)1.83868463
142Ulnar deviation of the wrist (HP:0003049)1.83699767
143Plantar hyperkeratosis (HP:0007556)1.83414636
144Increased connective tissue (HP:0009025)1.83065671
145Chronic obstructive pulmonary disease (HP:0006510)1.82644974
146Obstructive lung disease (HP:0006536)1.82644974
147Hypochromic microcytic anemia (HP:0004840)1.81361265
148Difficulty climbing stairs (HP:0003551)1.81172251
149Unilateral renal agenesis (HP:0000122)1.81164420
150Atrioventricular block (HP:0001678)1.79709454
151Aplasia cutis congenita (HP:0001057)1.78445978
152Arterial thrombosis (HP:0004420)1.78113714
153Muscle fibrillation (HP:0010546)1.78076014
154Recurrent abscess formation (HP:0002722)1.77682881
155Recurrent gram-negative bacterial infections (HP:0005420)1.77589579
156Hyperkalemia (HP:0002153)1.75280570
157Vertigo (HP:0002321)1.74792522
158Steppage gait (HP:0003376)1.74728227
159Abnormality of macrophages (HP:0004311)1.71557902
160Facial diplegia (HP:0001349)1.70424586
161Neoplasm of the heart (HP:0100544)1.69823532

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.49590135
2MAP3K102.67647474
3OBSCN2.56414719
4MAP4K22.55117190
5TTN2.50908594
6TAOK32.50689789
7MAP3K72.48431309
8FGFR42.42927957
9MAP4K12.40914625
10TXK2.33903288
11TNK22.33722582
12NME12.31112047
13EPHA32.29801153
14RIPK42.23434358
15EPHB12.19240941
16NLK2.14105769
17TRIB32.09307325
18SYK1.96054125
19EEF2K1.95782640
20JAK31.93377464
21FGFR31.83648957
22TYK21.81575990
23DYRK1B1.80131159
24TIE11.77077559
25ITK1.68381334
26FES1.66383809
27PTK61.65092344
28TESK21.64604630
29BTK1.64083062
30GRK61.62887692
31PKN21.62783742
32PINK11.58594345
33SIK31.53939497
34GRK71.52141618
35BLK1.49023616
36DMPK1.48806141
37STK101.48686926
38LMTK21.46680863
39ZAP701.41435479
40CHUK1.39307414
41TGFBR11.36659638
42PRPF4B1.35960903
43CDK121.34861929
44MST41.34619377
45CDK81.33549116
46CAMKK21.30755218
47CLK11.28903620
48CDC42BPA1.23298161
49IKBKE1.23280186
50JAK11.18526646
51LRRK21.13955724
52CAMKK11.13236270
53TBK11.12959700
54DYRK31.10770208
55MAP3K131.08451055
56PIK3CG1.07358358
57PHKG11.06928635
58PHKG21.06928635
59PDGFRB1.06526193
60MAPK121.03816612
61MAP2K41.01936607
62IRAK41.00594424
63CSK0.98663061
64PRKCQ0.97303459
65CAMK40.97298583
66HCK0.95225355
67MUSK0.94812075
68RPS6KB20.94457214
69MARK10.93552033
70ERBB30.93431590
71STK240.93392801
72STK110.91964085
73MAPK130.91365539
74JAK20.89915985
75MYLK0.86176096
76MAPKAPK30.86124856
77BMPR20.85328144
78LCK0.84425290
79TEC0.84242819
80NTRK30.80007125
81YES10.79347872
82PRKCH0.77548258
83PKN10.75794916
84PDK10.73337997
85MARK20.70677200
86LYN0.70334888
87MARK30.68961412
88KIT0.68568194
89CSF1R0.68344463
90BCKDK0.68052101
91IKBKB0.67963251
92FRK0.67733058
93HIPK20.67071181
94MAP3K110.67012783
95PDK40.65842243
96PDK30.65842243
97MAP2K60.65332977
98CDK90.63106120
99RIPK10.63024040
100RPS6KC10.62477646
101RPS6KL10.62477646
102PTK2B0.62465529
103PRKAA10.62226321
104MAPK40.60990072
105MAPK70.60771661
106ILK0.59010977
107TGFBR20.57996416
108FGR0.57287122
109TSSK60.56989791
110SIK20.55533165
111MAPKAPK20.55166027
112BRD40.55147244
113RPS6KA60.55142110
114SGK20.53084078
115MAPK110.52327106
116MAP3K60.50557477
117PRKAA20.50168657
118TRPM70.49527525
119PRKD10.48931405
120NTRK20.48179951
121STK380.47826465
122BMPR1B0.44948760
123PRKD20.43374022
124MAP2K30.41966504
125CAMK10.41697228
126ROCK20.40840428
127STK40.40803187
128KSR20.39270172
129FYN0.39154938
130TAOK10.39088139
131CCNB10.38535507
132RPS6KA10.37715293
133SGK30.37526618
134FGFR20.36593016
135DAPK20.35856021
136CDK30.35569133
137PIK3CA0.34887366
138ROCK10.34809155
139PDPK10.34316251
140MAPK30.33690241
141ERN10.32739499
142SGK4940.32351224
143SGK2230.32351224
144MAPKAPK50.31432227
145PRKDC0.31018418
146INSR0.29545928
147RET0.29418795
148NUAK10.28662722

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.50939638
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.26489545
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.76782727
4Antigen processing and presentation_Homo sapiens_hsa046122.58893438
5Non-homologous end-joining_Homo sapiens_hsa034502.48321238
6T cell receptor signaling pathway_Homo sapiens_hsa046602.40651090
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.39197286
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.20214253
9Dilated cardiomyopathy_Homo sapiens_hsa054141.88588773
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.88523276
11Viral myocarditis_Homo sapiens_hsa054161.83553961
12Graft-versus-host disease_Homo sapiens_hsa053321.83199138
13B cell receptor signaling pathway_Homo sapiens_hsa046621.75309414
14Staphylococcus aureus infection_Homo sapiens_hsa051501.68795458
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.55740694
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.55224436
17Osteoclast differentiation_Homo sapiens_hsa043801.54553212
18Toxoplasmosis_Homo sapiens_hsa051451.51027891
19Measles_Homo sapiens_hsa051621.49483241
20Leishmaniasis_Homo sapiens_hsa051401.46310064
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.45220679
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.40807564
23Hematopoietic cell lineage_Homo sapiens_hsa046401.34438934
24Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34245124
25Acute myeloid leukemia_Homo sapiens_hsa052211.33166724
26GnRH signaling pathway_Homo sapiens_hsa049121.20401840
27Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18954134
28Regulation of autophagy_Homo sapiens_hsa041401.18239898
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.17701456
30Phospholipase D signaling pathway_Homo sapiens_hsa040721.14157548
31Small cell lung cancer_Homo sapiens_hsa052221.13744887
32Malaria_Homo sapiens_hsa051441.12279842
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11592404
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11460017
35Cardiac muscle contraction_Homo sapiens_hsa042601.10819107
36Chemokine signaling pathway_Homo sapiens_hsa040621.10601192
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.06352129
38HTLV-I infection_Homo sapiens_hsa051661.05558239
39Chronic myeloid leukemia_Homo sapiens_hsa052201.04700117
40Adherens junction_Homo sapiens_hsa045201.04395036
41Asthma_Homo sapiens_hsa053101.03323265
42NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96944537
43Circadian entrainment_Homo sapiens_hsa047130.96672991
44Long-term potentiation_Homo sapiens_hsa047200.93958643
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93294257
46TNF signaling pathway_Homo sapiens_hsa046680.91384628
47Pancreatic cancer_Homo sapiens_hsa052120.89338206
48FoxO signaling pathway_Homo sapiens_hsa040680.89080455
49Type II diabetes mellitus_Homo sapiens_hsa049300.88544889
50Glycerophospholipid metabolism_Homo sapiens_hsa005640.88300530
51Type I diabetes mellitus_Homo sapiens_hsa049400.88034656
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87781071
53Prolactin signaling pathway_Homo sapiens_hsa049170.87718888
54Cholinergic synapse_Homo sapiens_hsa047250.87301978
55Allograft rejection_Homo sapiens_hsa053300.87300058
56mTOR signaling pathway_Homo sapiens_hsa041500.85246183
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84470744
58Apoptosis_Homo sapiens_hsa042100.81254259
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81146624
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80790176
61Focal adhesion_Homo sapiens_hsa045100.80637134
62Insulin resistance_Homo sapiens_hsa049310.79420616
63Other glycan degradation_Homo sapiens_hsa005110.79092327
64Autoimmune thyroid disease_Homo sapiens_hsa053200.79072164
65cAMP signaling pathway_Homo sapiens_hsa040240.78943998
66Herpes simplex infection_Homo sapiens_hsa051680.77825378
67Influenza A_Homo sapiens_hsa051640.77578209
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77470699
69Hepatitis B_Homo sapiens_hsa051610.77285202
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74938105
71Ovarian steroidogenesis_Homo sapiens_hsa049130.72446017
72MAPK signaling pathway_Homo sapiens_hsa040100.70055802
73Endometrial cancer_Homo sapiens_hsa052130.69765066
74Salivary secretion_Homo sapiens_hsa049700.69608912
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69183418
76Pathways in cancer_Homo sapiens_hsa052000.69103920
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69001455
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68873172
79VEGF signaling pathway_Homo sapiens_hsa043700.66377411
80Long-term depression_Homo sapiens_hsa047300.65980649
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65469685
82Inositol phosphate metabolism_Homo sapiens_hsa005620.64992412
83Amoebiasis_Homo sapiens_hsa051460.64921539
84Glioma_Homo sapiens_hsa052140.64803455
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62907193
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.62674293
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62365554
88Colorectal cancer_Homo sapiens_hsa052100.62212559
89Calcium signaling pathway_Homo sapiens_hsa040200.62131598
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61625971
91ABC transporters_Homo sapiens_hsa020100.61415813
92Morphine addiction_Homo sapiens_hsa050320.61023340
93Dorso-ventral axis formation_Homo sapiens_hsa043200.60807283
94Notch signaling pathway_Homo sapiens_hsa043300.59558713
95African trypanosomiasis_Homo sapiens_hsa051430.57068036
96Renal cell carcinoma_Homo sapiens_hsa052110.56671456
97ErbB signaling pathway_Homo sapiens_hsa040120.56000077
98Thyroid cancer_Homo sapiens_hsa052160.55904033
99Estrogen signaling pathway_Homo sapiens_hsa049150.54989324
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54968955
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54712809
102Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53449079
103Tuberculosis_Homo sapiens_hsa051520.52639144
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.52424416
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51651202
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51577413
107Platelet activation_Homo sapiens_hsa046110.51549258
108Oxytocin signaling pathway_Homo sapiens_hsa049210.51428500
109Non-small cell lung cancer_Homo sapiens_hsa052230.50201800
110MicroRNAs in cancer_Homo sapiens_hsa052060.49774837
111HIF-1 signaling pathway_Homo sapiens_hsa040660.47509759
112Choline metabolism in cancer_Homo sapiens_hsa052310.46686144
113Insulin signaling pathway_Homo sapiens_hsa049100.45512130
114Rap1 signaling pathway_Homo sapiens_hsa040150.45124287
115Epstein-Barr virus infection_Homo sapiens_hsa051690.44406802
116Viral carcinogenesis_Homo sapiens_hsa052030.44157038
117Phenylalanine metabolism_Homo sapiens_hsa003600.43710605
118Legionellosis_Homo sapiens_hsa051340.43480473
119Ras signaling pathway_Homo sapiens_hsa040140.43250311
120Prostate cancer_Homo sapiens_hsa052150.43122315
121Proteoglycans in cancer_Homo sapiens_hsa052050.42308947
122Melanoma_Homo sapiens_hsa052180.41653047
123p53 signaling pathway_Homo sapiens_hsa041150.40986499
124Glucagon signaling pathway_Homo sapiens_hsa049220.40871311
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.40537519
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.39803160
127Gastric acid secretion_Homo sapiens_hsa049710.38108510
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37864212
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37851394
130Olfactory transduction_Homo sapiens_hsa047400.36975785
131Linoleic acid metabolism_Homo sapiens_hsa005910.36028492
132Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35304428
133Basal cell carcinoma_Homo sapiens_hsa052170.33458886
134Renin secretion_Homo sapiens_hsa049240.32790028
135Circadian rhythm_Homo sapiens_hsa047100.32723108

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