COMMD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.28775810
2ribosomal small subunit assembly (GO:0000028)4.62858606
3DNA deamination (GO:0045006)4.61908303
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.46038732
5negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.35335755
6maturation of SSU-rRNA (GO:0030490)4.14362938
7positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.14093552
8anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.13769612
9regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.12418781
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.08024524
11ribosomal small subunit biogenesis (GO:0042274)4.03327713
12ribosomal large subunit biogenesis (GO:0042273)4.01062133
13mitotic metaphase plate congression (GO:0007080)3.99625456
14DNA double-strand break processing (GO:0000729)3.98955166
15viral transcription (GO:0019083)3.96357885
16negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.96045207
17negative regulation of ligase activity (GO:0051352)3.96045207
18translational termination (GO:0006415)3.93351633
19ATP synthesis coupled proton transport (GO:0015986)3.85936759
20energy coupled proton transport, down electrochemical gradient (GO:0015985)3.85936759
21formation of translation preinitiation complex (GO:0001731)3.78322183
22DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.75811444
23transcription elongation from RNA polymerase III promoter (GO:0006385)3.74708413
24termination of RNA polymerase III transcription (GO:0006386)3.74708413
25protein deneddylation (GO:0000338)3.70142481
26intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.68380326
27signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.68380326
28DNA replication checkpoint (GO:0000076)3.68080882
29SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.67091812
30signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.66418311
31signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.66418311
32signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.66418311
337-methylguanosine mRNA capping (GO:0006370)3.66287786
34positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.64224318
35CENP-A containing nucleosome assembly (GO:0034080)3.64070802
36establishment of integrated proviral latency (GO:0075713)3.64028174
37regulation of cellular amino acid metabolic process (GO:0006521)3.62387654
38cotranslational protein targeting to membrane (GO:0006613)3.61731797
39antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.61362954
40telomere maintenance via semi-conservative replication (GO:0032201)3.59562913
417-methylguanosine RNA capping (GO:0009452)3.58075278
42RNA capping (GO:0036260)3.58075278
43protein targeting to ER (GO:0045047)3.56766415
44DNA strand elongation involved in DNA replication (GO:0006271)3.56411194
45signal transduction involved in DNA damage checkpoint (GO:0072422)3.56376205
46signal transduction involved in DNA integrity checkpoint (GO:0072401)3.56376205
47regulation of mitotic spindle checkpoint (GO:1903504)3.54989774
48regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.54989774
49signal transduction involved in cell cycle checkpoint (GO:0072395)3.52061964
50positive regulation of ligase activity (GO:0051351)3.51523136
51translational initiation (GO:0006413)3.51292085
52translational elongation (GO:0006414)3.50066832
53RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.49267460
54tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.49267460
55L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.48640164
56ribonucleoprotein complex biogenesis (GO:0022613)3.45817451
57chromatin remodeling at centromere (GO:0031055)3.45503179
58rRNA modification (GO:0000154)3.45356123
59telomere maintenance via recombination (GO:0000722)3.44504116
60maturation of 5.8S rRNA (GO:0000460)3.44336180
61DNA ligation (GO:0006266)3.44047986
62antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.43061294
63cullin deneddylation (GO:0010388)3.42578228
64protein localization to endoplasmic reticulum (GO:0070972)3.41505781
65purine nucleobase biosynthetic process (GO:0009113)3.40577346
66DNA strand elongation (GO:0022616)3.38831661
67histone exchange (GO:0043486)3.38288153
68metaphase plate congression (GO:0051310)3.36329849
69establishment of protein localization to endoplasmic reticulum (GO:0072599)3.35989427
70mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.35484760
71attachment of spindle microtubules to kinetochore (GO:0008608)3.34222909
72rRNA processing (GO:0006364)3.31075106
73translation (GO:0006412)3.30985982
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.27961628
75transcription-coupled nucleotide-excision repair (GO:0006283)3.25295382
76deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.23859233
77regulation of ubiquitin-protein transferase activity (GO:0051438)3.23663253
78nucleobase biosynthetic process (GO:0046112)3.23574928
79nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.23273654
80kinetochore organization (GO:0051383)3.22986706
81spliceosomal snRNP assembly (GO:0000387)3.22721129
82kinetochore assembly (GO:0051382)3.21864561
83DNA replication-independent nucleosome organization (GO:0034724)3.20195139
84DNA replication-independent nucleosome assembly (GO:0006336)3.20195139
85pseudouridine synthesis (GO:0001522)3.19826217
86rRNA metabolic process (GO:0016072)3.17956968
87protein complex biogenesis (GO:0070271)3.17513795
88viral life cycle (GO:0019058)3.17417029
89mitochondrial respiratory chain complex assembly (GO:0033108)3.15723881
90regulation of helicase activity (GO:0051095)3.15099992
91regulation of ligase activity (GO:0051340)3.14792488
92protein K6-linked ubiquitination (GO:0085020)3.13387998
93establishment of chromosome localization (GO:0051303)3.13379880
94mitotic recombination (GO:0006312)3.12588031
95nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.12004581
96DNA replication initiation (GO:0006270)3.11967962
97DNA damage response, detection of DNA damage (GO:0042769)3.11061266
98RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.10896248
99termination of RNA polymerase I transcription (GO:0006363)3.10388594
100cellular protein complex disassembly (GO:0043624)3.09279020
101negative regulation of DNA-dependent DNA replication (GO:2000104)3.08694149
102ribosome biogenesis (GO:0042254)3.08493303
103sequestering of actin monomers (GO:0042989)3.08022738
104mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.07357047
105mitochondrial respiratory chain complex I assembly (GO:0032981)3.07357047
106NADH dehydrogenase complex assembly (GO:0010257)3.07357047
107DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.06887998
108transcription elongation from RNA polymerase I promoter (GO:0006362)3.05875904
109G1/S transition of mitotic cell cycle (GO:0000082)3.05320958
110cell cycle G1/S phase transition (GO:0044843)3.05320958
111protein neddylation (GO:0045116)3.05211803
112DNA catabolic process, exonucleolytic (GO:0000738)3.05150774
113organelle disassembly (GO:1903008)3.04896526
114telomere maintenance via telomere lengthening (GO:0010833)3.03439223
115resolution of meiotic recombination intermediates (GO:0000712)3.03311907
116protein localization to kinetochore (GO:0034501)3.02793494
117regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.01462100
118spliceosomal complex assembly (GO:0000245)3.01440889
119spindle checkpoint (GO:0031577)2.99898272
120histone mRNA metabolic process (GO:0008334)2.98217325
121chaperone-mediated protein transport (GO:0072321)2.97803567
122ribosome assembly (GO:0042255)2.97563435
123transcription from RNA polymerase I promoter (GO:0006360)2.97293704
124positive regulation of cell cycle arrest (GO:0071158)2.96932337
125cellular component biogenesis (GO:0044085)2.96714898
126L-methionine salvage (GO:0071267)2.96025184
127L-methionine biosynthetic process (GO:0071265)2.96025184
128amino acid salvage (GO:0043102)2.96025184
129replication fork processing (GO:0031297)2.95008761
130pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.94872760
131pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.94050719
132mitotic spindle checkpoint (GO:0071174)2.93994748
133negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.93241778
134negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.93241778
135negative regulation of mitotic sister chromatid segregation (GO:0033048)2.93241778
136negative regulation of mitotic sister chromatid separation (GO:2000816)2.93241778
137negative regulation of sister chromatid segregation (GO:0033046)2.93241778
138response to pheromone (GO:0019236)2.90615357
139DNA replication-dependent nucleosome assembly (GO:0006335)2.89853125
140DNA replication-dependent nucleosome organization (GO:0034723)2.89853125
141respiratory electron transport chain (GO:0022904)2.85897864
142transcription elongation from RNA polymerase II promoter (GO:0006368)2.82590060
143negative regulation of chromosome segregation (GO:0051985)2.82098640
144respiratory chain complex IV assembly (GO:0008535)2.81876146
145electron transport chain (GO:0022900)2.80886878
146protein K11-linked ubiquitination (GO:0070979)2.78288015
147water-soluble vitamin biosynthetic process (GO:0042364)2.75918478
148establishment of viral latency (GO:0019043)2.74884930
149protein-cofactor linkage (GO:0018065)2.74212658
150mitotic spindle assembly checkpoint (GO:0007094)2.73913277
151spindle assembly checkpoint (GO:0071173)2.73314572
152platelet dense granule organization (GO:0060155)2.69928847
153intraciliary transport (GO:0042073)2.69889308
154double-strand break repair via nonhomologous end joining (GO:0006303)2.68780033
155non-recombinational repair (GO:0000726)2.68780033

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.05449033
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.43794274
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.05556306
4* GABP_17652178_ChIP-ChIP_JURKAT_Human4.01988098
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.78152386
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.69951682
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.63519815
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.47269421
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.36252936
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.21497238
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.96282317
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.92025381
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.88770207
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.74088504
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.72730962
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.72059521
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.71675720
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.67996198
19VDR_23849224_ChIP-Seq_CD4+_Human2.65503016
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.56412389
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.56367674
22* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.51615899
23ZNF274_21170338_ChIP-Seq_K562_Hela2.45077090
24DCP1A_22483619_ChIP-Seq_HELA_Human2.39647720
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34759543
26EWS_26573619_Chip-Seq_HEK293_Human2.33190676
27XRN2_22483619_ChIP-Seq_HELA_Human2.32433902
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.31661049
29FOXP3_21729870_ChIP-Seq_TREG_Human2.18262295
30FUS_26573619_Chip-Seq_HEK293_Human2.15913577
31SALL1_21062744_ChIP-ChIP_HESCs_Human2.15395836
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.13054289
33* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.12791009
34* GABP_19822575_ChIP-Seq_HepG2_Human2.10837408
35* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09948317
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.07190337
37SRF_21415370_ChIP-Seq_HL-1_Mouse2.06034357
38ELK1_19687146_ChIP-ChIP_HELA_Human2.05055867
39* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.96220967
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.95342364
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.93427739
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.92169041
43TTF2_22483619_ChIP-Seq_HELA_Human1.91984107
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.90005271
45VDR_22108803_ChIP-Seq_LS180_Human1.86810052
46IGF1R_20145208_ChIP-Seq_DFB_Human1.85315644
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81307376
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76569516
49TAF15_26573619_Chip-Seq_HEK293_Human1.75796547
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74715665
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.69666642
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68923855
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.68145328
54P300_19829295_ChIP-Seq_ESCs_Human1.66223095
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61029434
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59591110
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.58238818
58AR_21909140_ChIP-Seq_LNCAP_Human1.57305501
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.54483571
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54029953
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52890199
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52200453
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50029845
64* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49651155
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.46761225
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44958675
67GBX2_23144817_ChIP-Seq_PC3_Human1.43565540
68IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.42813125
69YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42150229
70NANOG_16153702_ChIP-ChIP_HESCs_Human1.41097880
71ELK1_22589737_ChIP-Seq_MCF10A_Human1.40078139
72* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39825075
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.39227536
74SOX2_16153702_ChIP-ChIP_HESCs_Human1.37021152
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33035762
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32775270
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32496364
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32133354
79KDM5A_27292631_Chip-Seq_BREAST_Human1.30659923
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.28228737
81MYC_18940864_ChIP-ChIP_HL60_Human1.25533158
82CIITA_25753668_ChIP-Seq_RAJI_Human1.24518267
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23238965
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23123379
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23122939
86SPI1_23547873_ChIP-Seq_NB4_Human1.22865135
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21049511
88IRF8_22096565_ChIP-ChIP_GC-B_Human1.19832661
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16110260
90IRF8_21731497_ChIP-ChIP_J774_Mouse1.14619532
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13126879
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12979362
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12507309
94HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11780254
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11696271
96* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11661527
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10998719
98TFEB_21752829_ChIP-Seq_HELA_Human1.08863658
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08302724
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.04735475
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02261699
102CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99870589
103* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99790117
104* NANOG_19829295_ChIP-Seq_ESCs_Human0.96263865
105* SOX2_19829295_ChIP-Seq_ESCs_Human0.96263865
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95516067
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94875217
108EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94810525
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94808707
110CBP_20019798_ChIP-Seq_JUKART_Human0.94475154
111IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94475154
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94049626
113TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93835924
114* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93643359
115CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92716656
116STAT4_19710469_ChIP-ChIP_TH1__Mouse0.91972405
117CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91079551
118SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91000366
119NFE2_27457419_Chip-Seq_LIVER_Mouse0.90842750
120RNF2_27304074_Chip-Seq_NSC_Mouse0.90534423
121FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90406639
122TP53_22573176_ChIP-Seq_HFKS_Human0.89758024
123IRF1_19129219_ChIP-ChIP_H3396_Human0.89693630
124MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89382626
125PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89314114
126ER_23166858_ChIP-Seq_MCF-7_Human0.89070574
127KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88224161
128HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87859194
129CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87494537
130DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86472753
131* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85780030
132SOX17_20123909_ChIP-Seq_XEN_Mouse0.84493251
133KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.82854837
134SOX2_18555785_ChIP-Seq_MESCs_Mouse0.77551534
135POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.77494847
136STAT3_1855785_ChIP-Seq_MESCs_Mouse0.75244764
137HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.74565200
138TBX5_21415370_ChIP-Seq_HL-1_Mouse0.70214525
139MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.68952913
140DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.68213233
141TP63_19390658_ChIP-ChIP_HaCaT_Human0.68129250
142RBPJ_22232070_ChIP-Seq_NCS_Mouse0.67716625

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.53740308
2MP0004957_abnormal_blastocyst_morpholog3.93466319
3MP0010094_abnormal_chromosome_stability3.54938409
4MP0003111_abnormal_nucleus_morphology3.44452781
5MP0003077_abnormal_cell_cycle3.44002322
6MP0008058_abnormal_DNA_repair2.97133901
7MP0003718_maternal_effect2.82219486
8MP0008007_abnormal_cellular_replicative2.70192941
9MP0008057_abnormal_DNA_replication2.63946847
10MP0008932_abnormal_embryonic_tissue2.60950938
11MP0003890_abnormal_embryonic-extraembry2.40805767
12MP0008789_abnormal_olfactory_epithelium2.39693804
13MP0003186_abnormal_redox_activity2.31885124
14MP0003786_premature_aging2.20423737
15MP0002938_white_spotting2.18510371
16MP0001293_anophthalmia2.08147335
17MP0009333_abnormal_splenocyte_physiolog2.06378689
18MP0003763_abnormal_thymus_physiology2.06246003
19MP0005084_abnormal_gallbladder_morpholo2.02757278
20MP0009379_abnormal_foot_pigmentation1.96550238
21MP0009785_altered_susceptibility_to1.88227146
22MP0006072_abnormal_retinal_apoptosis1.88082287
23MP0005671_abnormal_response_to1.87959956
24MP0005394_taste/olfaction_phenotype1.82355735
25MP0005499_abnormal_olfactory_system1.82355735
26MP0003880_abnormal_central_pattern1.80261621
27MP0001835_abnormal_antigen_presentation1.71262900
28MP0003315_abnormal_perineum_morphology1.70793223
29MP0003941_abnormal_skin_development1.66771113
30MP0003806_abnormal_nucleotide_metabolis1.66295885
31MP0000490_abnormal_crypts_of1.65076325
32MP0002396_abnormal_hematopoietic_system1.64926186
33MP0003937_abnormal_limbs/digits/tail_de1.63951926
34MP0001984_abnormal_olfaction1.62358454
35MP0002751_abnormal_autonomic_nervous1.61867085
36MP0002132_abnormal_respiratory_system1.60416901
37MP0008260_abnormal_autophagy1.56654825
38MP0002234_abnormal_pharynx_morphology1.56285635
39MP0003119_abnormal_digestive_system1.55685275
40MP0000049_abnormal_middle_ear1.55563216
41MP0006276_abnormal_autonomic_nervous1.52744327
42MP0003567_abnormal_fetal_cardiomyocyte1.52221379
43MP0002638_abnormal_pupillary_reflex1.51823801
44MP0001730_embryonic_growth_arrest1.51650432
45MP0004133_heterotaxia1.48294240
46MP0000350_abnormal_cell_proliferation1.47761335
47MP0002736_abnormal_nociception_after1.47638295
48MP0001286_abnormal_eye_development1.47549552
49MP0005253_abnormal_eye_physiology1.47336338
50MP0002233_abnormal_nose_morphology1.47048833
51MP0005451_abnormal_body_composition1.45950480
52MP0002019_abnormal_tumor_incidence1.42379098
53MP0008877_abnormal_DNA_methylation1.42108458
54MP0002148_abnormal_hypersensitivity_rea1.40639754
55MP0000566_synostosis1.37609801
56MP0001188_hyperpigmentation1.35558297
57MP0002398_abnormal_bone_marrow1.35440527
58MP0003724_increased_susceptibility_to1.35102303
59MP0003121_genomic_imprinting1.35076023
60MP0008995_early_reproductive_senescence1.34697902
61MP0009697_abnormal_copulation1.34290190
62MP0000647_abnormal_sebaceous_gland1.31103673
63MP0001853_heart_inflammation1.30437445
64MP0003123_paternal_imprinting1.28326470
65MP0005408_hypopigmentation1.26445627
66MP0005000_abnormal_immune_tolerance1.25723559
67MP0000858_altered_metastatic_potential1.25379247
68MP0006292_abnormal_olfactory_placode1.24696333
69MP0000372_irregular_coat_pigmentation1.24621232
70MP0002102_abnormal_ear_morphology1.24619037
71MP0000778_abnormal_nervous_system1.24434017
72MP0002420_abnormal_adaptive_immunity1.24395177
73MP0001819_abnormal_immune_cell1.23959758
74MP0000689_abnormal_spleen_morphology1.23269131
75MP0002163_abnormal_gland_morphology1.23155693
76MP0000313_abnormal_cell_death1.22719605
77MP0000631_abnormal_neuroendocrine_gland1.22524406
78MP0002653_abnormal_ependyma_morphology1.21737635
79MP0002452_abnormal_antigen_presenting1.21183116
80MP0002722_abnormal_immune_system1.21176064
81MP0005025_abnormal_response_to1.20235543
82MP0001800_abnormal_humoral_immune1.20033122
83MP0003755_abnormal_palate_morphology1.19446052
84MP0004782_abnormal_surfactant_physiolog1.18767078
85MP0002723_abnormal_immune_serum1.18154230
86MP0001119_abnormal_female_reproductive1.17866257
87MP0000716_abnormal_immune_system1.15539638
88MP0002429_abnormal_blood_cell1.14493881
89MP0001697_abnormal_embryo_size1.11582168
90MP0005391_vision/eye_phenotype1.11083909
91MP0002282_abnormal_trachea_morphology1.10566762
92MP0002697_abnormal_eye_size1.07632133
93MP0005187_abnormal_penis_morphology1.06830700
94MP0000685_abnormal_immune_system1.06815639
95MP0001485_abnormal_pinna_reflex1.05918982
96MP0003938_abnormal_ear_development1.05589295
97MP0006036_abnormal_mitochondrial_physio1.05366470
98MP0000703_abnormal_thymus_morphology1.05330453
99MP0003787_abnormal_imprinting1.04770164
100MP0005551_abnormal_eye_electrophysiolog1.04691100
101MP0005171_absent_coat_pigmentation1.03860575
102MP0006082_CNS_inflammation1.03679716
103MP0001542_abnormal_bone_strength1.03278889
104MP0001324_abnormal_eye_pigmentation1.02121761
105MP0002210_abnormal_sex_determination1.01003364
106MP0002084_abnormal_developmental_patter0.99125903
107MP0002405_respiratory_system_inflammati0.98850880
108MP0002090_abnormal_vision0.95932832
109MP0005397_hematopoietic_system_phenotyp0.95871854
110MP0001545_abnormal_hematopoietic_system0.95871854
111MP0002080_prenatal_lethality0.95587288
112MP0001986_abnormal_taste_sensitivity0.94333992
113MP0003122_maternal_imprinting0.93980331
114MP0001177_atelectasis0.93433312
115MP0001672_abnormal_embryogenesis/_devel0.93159546
116MP0005380_embryogenesis_phenotype0.93159546
117MP0005389_reproductive_system_phenotype0.92321093
118MP0002752_abnormal_somatic_nervous0.92156358
119MP0002419_abnormal_innate_immunity0.91516707
120MP0004142_abnormal_muscle_tone0.91374556
121MP0003436_decreased_susceptibility_to0.90704958
122MP0005195_abnormal_posterior_eye0.90398933
123MP0000358_abnormal_cell_content/0.89561846
124MP0001919_abnormal_reproductive_system0.89340971
125MP0005395_other_phenotype0.88753857
126MP0003283_abnormal_digestive_organ0.85965150
127MP0004147_increased_porphyrin_level0.85681623
128MP0002111_abnormal_tail_morphology0.85362747
129MP0000653_abnormal_sex_gland0.85168243
130MP0001145_abnormal_male_reproductive0.84063852
131MP0002160_abnormal_reproductive_system0.82977208
132MP0001764_abnormal_homeostasis0.82889990
133MP0001529_abnormal_vocalization0.82216047
134MP0001486_abnormal_startle_reflex0.81858292
135MP0002277_abnormal_respiratory_mucosa0.81668487
136MP0006054_spinal_hemorrhage0.80296779
137MP0003136_yellow_coat_color0.79861155
138MP0005367_renal/urinary_system_phenotyp0.79790464
139MP0000516_abnormal_urinary_system0.79790464
140MP0003984_embryonic_growth_retardation0.79070280
141MP0001845_abnormal_inflammatory_respons0.78654836
142MP0010155_abnormal_intestine_physiology0.77851191
143MP0003861_abnormal_nervous_system0.77804075
144MP0001968_abnormal_touch/_nociception0.77541276
145MP0001299_abnormal_eye_distance/0.76040354
146MP0002095_abnormal_skin_pigmentation0.75359154
147MP0002088_abnormal_embryonic_growth/wei0.74889531
148MP0010307_abnormal_tumor_latency0.74688145
149MP0002933_joint_inflammation0.74249964
150MP0001929_abnormal_gametogenesis0.74210252
151MP0003011_delayed_dark_adaptation0.74193197
152MP0006035_abnormal_mitochondrial_morpho0.73283532
153MP0002085_abnormal_embryonic_tissue0.73025671
154MP0004808_abnormal_hematopoietic_stem0.72954121
155MP0002928_abnormal_bile_duct0.72552943
156MP0000427_abnormal_hair_cycle0.72380820
157MP0000465_gastrointestinal_hemorrhage0.72251710
158MP0002006_tumorigenesis0.71805816
159MP0002184_abnormal_innervation0.71471240
160MP0010352_gastrointestinal_tract_polyps0.71116375
161MP0001790_abnormal_immune_system0.71114019
162MP0005387_immune_system_phenotype0.71114019
163MP0010030_abnormal_orbit_morphology0.68753761

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)3.96826998
2Abnormality of cells of the erythroid lineage (HP:0012130)3.94811729
3Abnormal number of erythroid precursors (HP:0012131)3.79603151
4Reticulocytopenia (HP:0001896)3.58351065
5Increased hepatocellular lipid droplets (HP:0006565)3.53000770
6Aplastic anemia (HP:0001915)3.38585209
7Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.36031131
8Cerebral hypomyelination (HP:0006808)3.35769993
9Oral leukoplakia (HP:0002745)3.35644595
10Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.31141465
11Decreased activity of mitochondrial respiratory chain (HP:0008972)3.31141465
12Exertional dyspnea (HP:0002875)3.25070202
13Breast hypoplasia (HP:0003187)3.20176287
14Abnormality of the labia minora (HP:0012880)3.18495133
15Mitochondrial inheritance (HP:0001427)3.18279026
16Hepatocellular necrosis (HP:0001404)3.18074056
17Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.16919185
18Rough bone trabeculation (HP:0100670)3.15703083
19Pancreatic cysts (HP:0001737)3.13632659
20True hermaphroditism (HP:0010459)3.10096361
21Pancreatic fibrosis (HP:0100732)3.07468756
22Renal Fanconi syndrome (HP:0001994)3.05053917
23Lipid accumulation in hepatocytes (HP:0006561)3.05010609
24Acute necrotizing encephalopathy (HP:0006965)3.02088336
253-Methylglutaconic aciduria (HP:0003535)3.01099823
26Increased CSF lactate (HP:0002490)2.98435465
27Type I transferrin isoform profile (HP:0003642)2.88472375
28Hepatic necrosis (HP:0002605)2.87486267
29Abnormal mitochondria in muscle tissue (HP:0008316)2.86590000
30Increased serum lactate (HP:0002151)2.85218539
31Macrocytic anemia (HP:0001972)2.85038526
32Microretrognathia (HP:0000308)2.83763772
33Medial flaring of the eyebrow (HP:0010747)2.77203953
34Increased intramyocellular lipid droplets (HP:0012240)2.71342005
35Secondary amenorrhea (HP:0000869)2.70128745
36Aplasia/Hypoplasia of the sacrum (HP:0008517)2.65944002
37Carpal bone hypoplasia (HP:0001498)2.65776485
38Respiratory difficulties (HP:0002880)2.65180518
39Degeneration of anterior horn cells (HP:0002398)2.63993451
40Abnormality of the anterior horn cell (HP:0006802)2.63993451
41Molar tooth sign on MRI (HP:0002419)2.62864868
42Abnormality of midbrain morphology (HP:0002418)2.62864868
43Congenital primary aphakia (HP:0007707)2.56986523
44Nephrogenic diabetes insipidus (HP:0009806)2.52584750
45Gait imbalance (HP:0002141)2.52232178
46Pallor (HP:0000980)2.50383308
47Patellar aplasia (HP:0006443)2.48526949
48Cortical dysplasia (HP:0002539)2.44636298
49Premature graying of hair (HP:0002216)2.44376494
50Aplasia/Hypoplasia of the patella (HP:0006498)2.43055083
51Acute encephalopathy (HP:0006846)2.42808478
52Abnormality of glycolysis (HP:0004366)2.42608217
53Increased serum pyruvate (HP:0003542)2.42608217
54IgM deficiency (HP:0002850)2.42412846
55Abnormal trabecular bone morphology (HP:0100671)2.42231041
56Septo-optic dysplasia (HP:0100842)2.36370421
57Nephronophthisis (HP:0000090)2.36059612
58Methylmalonic acidemia (HP:0002912)2.35915856
59Abnormality of the preputium (HP:0100587)2.35753853
60Genital tract atresia (HP:0001827)2.32634621
61Progressive macrocephaly (HP:0004481)2.31006763
62Meckel diverticulum (HP:0002245)2.30638081
63Methylmalonic aciduria (HP:0012120)2.30201645
64Vaginal atresia (HP:0000148)2.28908574
65Premature ovarian failure (HP:0008209)2.28037523
66Cerebral edema (HP:0002181)2.27557072
67Abnormal lung lobation (HP:0002101)2.24421371
68Cleft eyelid (HP:0000625)2.24366769
69Agnosia (HP:0010524)2.22520052
70Increased muscle lipid content (HP:0009058)2.19206568
71Supernumerary spleens (HP:0009799)2.18706719
72Abnormality of the ileum (HP:0001549)2.18158597
73Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.17833681
74Exercise intolerance (HP:0003546)2.17386290
75Stenosis of the external auditory canal (HP:0000402)2.16143478
76Abnormality of chromosome stability (HP:0003220)2.15640640
77Abnormality of serum amino acid levels (HP:0003112)2.15518633
78Recurrent abscess formation (HP:0002722)2.15323456
79Trismus (HP:0000211)2.14794700
80Bifid tongue (HP:0010297)2.14624382
81Elevated erythrocyte sedimentation rate (HP:0003565)2.13849016
82Muscle fiber atrophy (HP:0100295)2.13661302
83Bone marrow hypocellularity (HP:0005528)2.13166532
84Type 2 muscle fiber atrophy (HP:0003554)2.12401201
85Abolished electroretinogram (ERG) (HP:0000550)2.11503868
86Poor head control (HP:0002421)2.10460453
87Sclerocornea (HP:0000647)2.09846633
88Microvesicular hepatic steatosis (HP:0001414)2.09115975
89Hyperglycinemia (HP:0002154)2.07692329
90Absent thumb (HP:0009777)2.07050315
91Thrombocytosis (HP:0001894)2.06925909
92Neoplasm of the adrenal gland (HP:0100631)2.06463778
93Lactic acidosis (HP:0003128)2.06231129
94Bilateral microphthalmos (HP:0007633)2.05707441
95Chromsome breakage (HP:0040012)2.04922713
96Optic nerve hypoplasia (HP:0000609)2.04764117
97Multiple enchondromatosis (HP:0005701)2.04307593
98Respiratory failure (HP:0002878)2.03483881
99Prolonged neonatal jaundice (HP:0006579)2.02709846
100Anencephaly (HP:0002323)2.01786301
101Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00936990
102Abnormal protein N-linked glycosylation (HP:0012347)2.00936990
103Abnormal protein glycosylation (HP:0012346)2.00936990
104Abnormal glycosylation (HP:0012345)2.00936990
105Aplasia/Hypoplasia of the tongue (HP:0010295)2.00817850
106IgG deficiency (HP:0004315)1.99053884
107Myelodysplasia (HP:0002863)1.97632586
108Abnormality of the renal medulla (HP:0100957)1.97080589
109Reduced antithrombin III activity (HP:0001976)1.96692216
110Progressive inability to walk (HP:0002505)1.96489374
111CNS hypomyelination (HP:0003429)1.95700267
112Triphalangeal thumb (HP:0001199)1.95462268
113Sparse eyelashes (HP:0000653)1.95458566
114Abnormality of methionine metabolism (HP:0010901)1.94570254
115Colon cancer (HP:0003003)1.93874855
116Optic disc pallor (HP:0000543)1.93553117
11711 pairs of ribs (HP:0000878)1.93501297
118Selective tooth agenesis (HP:0001592)1.92448471
119Abnormality of aspartate family amino acid metabolism (HP:0010899)1.92423216
120Neoplasm of the adrenal cortex (HP:0100641)1.91720456
121Preaxial hand polydactyly (HP:0001177)1.91497373
122Inability to walk (HP:0002540)1.90922047
123Pancytopenia (HP:0001876)1.90752588
124Abnormality of alanine metabolism (HP:0010916)1.90660382
125Hyperalaninemia (HP:0003348)1.90660382
126Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90660382
127Leukodystrophy (HP:0002415)1.90032625
128Absent septum pellucidum (HP:0001331)1.89767324
129Pulmonary fibrosis (HP:0002206)1.89596643
130Irregular epiphyses (HP:0010582)1.88985914
131Recurrent bacterial skin infections (HP:0005406)1.87346576
132Dandy-Walker malformation (HP:0001305)1.87037881
133Poor coordination (HP:0002370)1.86385282
134Small intestinal stenosis (HP:0012848)1.85989306
135Duodenal stenosis (HP:0100867)1.85989306
136Cellular immunodeficiency (HP:0005374)1.85240550
137Abnormality of the septum pellucidum (HP:0007375)1.84764945
138Abnormality of the umbilical cord (HP:0010881)1.84030079
139CNS demyelination (HP:0007305)1.83857183
140Esophageal atresia (HP:0002032)1.82643535
141Gastrointestinal atresia (HP:0002589)1.82559620
142Glossoptosis (HP:0000162)1.82554886
143Abnormal hemoglobin (HP:0011902)1.82048860
144Postaxial foot polydactyly (HP:0001830)1.79980424
145Sloping forehead (HP:0000340)1.79063065
146Aplasia/Hypoplasia of the uvula (HP:0010293)1.78370182
147Intestinal atresia (HP:0011100)1.78060176
148Abnormality of renal resorption (HP:0011038)1.77890946
149Renal cortical cysts (HP:0000803)1.74717409
150Abnormality of glycine metabolism (HP:0010895)1.74623616
151Abnormality of serine family amino acid metabolism (HP:0010894)1.74623616
152Anophthalmia (HP:0000528)1.73988219
153Abnormality of the duodenum (HP:0002246)1.73319454
154Adrenal hypoplasia (HP:0000835)1.72709034
155Postaxial hand polydactyly (HP:0001162)1.71618908
156Broad foot (HP:0001769)1.70161510

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.12359576
2NME23.42604028
3STK163.42316319
4EIF2AK13.27426015
5WEE13.05009632
6PLK42.84596172
7VRK22.68520992
8TRIM282.59528031
9PBK2.41977653
10TESK22.40902360
11ACVR1B2.31837153
12WNK32.31297691
13EIF2AK32.20521249
14CDC72.17926779
15SRPK12.13167810
16VRK12.11331978
17CASK2.00243872
18CCNB11.90542840
19PIM21.70747778
20MAP3K41.67801404
21TLK11.64571725
22BRSK21.60242870
23DYRK31.57238260
24ERBB31.57088944
25TTK1.53848383
26PLK11.53618090
27RPS6KA41.53455882
28TSSK61.44196991
29BRAF1.39808537
30CSNK1G11.34980062
31NEK21.34617813
32IRAK31.34174773
33MST41.33931223
34MAP2K71.33917670
35AURKB1.32725196
36CDK81.32191742
37CSNK1G21.30783825
38MKNK11.29713790
39ARAF1.28314943
40MAP4K21.25088464
41IRAK41.24353182
42AURKA1.23083831
43LIMK11.21986152
44TESK11.20340435
45FRK1.19846227
46TNIK1.16769032
47PLK31.16698601
48PLK21.16648980
49ZAK1.11467148
50TXK1.10222230
51CSNK1A1L1.07797727
52BMPR1B1.07226363
53TGFBR11.04949803
54DYRK21.04727998
55CDK191.04434787
56KDR1.02543817
57NME11.01986159
58CDK71.00630313
59MAP4K10.98420334
60ZAP700.97058676
61CHEK20.95583489
62MAP3K120.94931366
63STK38L0.90912653
64MKNK20.90547318
65MOS0.90285456
66EIF2AK20.90002720
67GRK10.86704977
68MAPK130.86653602
69ADRBK20.86418977
70MAP3K80.85893770
71PDK20.85684913
72TAF10.84839600
73NUAK10.84146474
74TBK10.83916592
75MAP3K110.83807752
76ATR0.80333809
77OXSR10.78826230
78TEC0.77511052
79STK100.77233470
80RPS6KB20.76340548
81ILK0.75495991
82NLK0.75261612
83BRSK10.74440144
84STK30.73928528
85MARK10.72494323
86NEK90.72026758
87STK390.71718201
88EPHA20.71617006
89ABL20.69937942
90ERBB40.69701658
91IKBKE0.69589883
92BLK0.68106190
93JAK30.66870150
94PAK10.66657653
95CSNK2A10.66564291
96MINK10.66457968
97PAK40.65875771
98TYK20.65311402
99RPS6KA50.64754878
100PASK0.64317547
101BMPR20.63682527
102PIM10.63272359
103MELK0.63021789
104PINK10.62849001
105BRD40.61384627
106IRAK10.58997361
107STK40.58943181
108TIE10.57502733
109PNCK0.57362308
110ATM0.57004700
111PRKCI0.56192535
112KIT0.55938175
113PRKCG0.55527576
114IKBKB0.54606440
115INSRR0.53464786
116BCR0.53370903
117CLK10.52966873
118PRKCE0.51901467
119CSNK2A20.49498690
120MAP3K140.48046552
121STK240.47149918
122NEK10.46133183
123BTK0.44511263
124CDK30.44021903
125MAP3K30.42865463
126CDK40.42860820
127LRRK20.41136359
128MAP2K30.38171530
129CSNK1G30.37308833
130CHEK10.37294274
131MYLK0.36970301
132LYN0.36176333
133MUSK0.36008314
134BCKDK0.34968044
135FGFR10.34647361
136PAK30.34176978
137IRAK20.33697627
138DYRK1A0.33533473
139CSNK1E0.32583323
140CSNK1A10.32580060
141EPHA40.31078382
142MAP2K60.30536730
143LATS10.27568457
144WNK40.27523209
145FGFR20.27358174
146SIK30.26582598
147CAMK2A0.26485572

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.63988440
2Ribosome_Homo sapiens_hsa030104.14524699
3RNA polymerase_Homo sapiens_hsa030203.90044132
4DNA replication_Homo sapiens_hsa030303.69007220
5Mismatch repair_Homo sapiens_hsa034303.09659534
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.00977671
7Spliceosome_Homo sapiens_hsa030402.66180836
8Base excision repair_Homo sapiens_hsa034102.65526670
9Pyrimidine metabolism_Homo sapiens_hsa002402.61060892
10Nucleotide excision repair_Homo sapiens_hsa034202.56552335
11Homologous recombination_Homo sapiens_hsa034402.55025180
12Protein export_Homo sapiens_hsa030602.41642797
13RNA transport_Homo sapiens_hsa030132.36922852
14Propanoate metabolism_Homo sapiens_hsa006402.11749780
15Basal transcription factors_Homo sapiens_hsa030222.11725335
16Cell cycle_Homo sapiens_hsa041102.10879577
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.99069998
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.98016168
19RNA degradation_Homo sapiens_hsa030181.91497830
20Steroid biosynthesis_Homo sapiens_hsa001001.82339366
21Fanconi anemia pathway_Homo sapiens_hsa034601.77944189
22Oxidative phosphorylation_Homo sapiens_hsa001901.64407130
23Parkinsons disease_Homo sapiens_hsa050121.57497424
24One carbon pool by folate_Homo sapiens_hsa006701.48460076
25Non-homologous end-joining_Homo sapiens_hsa034501.47490925
26p53 signaling pathway_Homo sapiens_hsa041151.40601040
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40195069
28Purine metabolism_Homo sapiens_hsa002301.39465250
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37726095
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35532760
31Huntingtons disease_Homo sapiens_hsa050161.32325630
32Folate biosynthesis_Homo sapiens_hsa007901.29006493
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25992312
34Fatty acid elongation_Homo sapiens_hsa000621.25178265
35Epstein-Barr virus infection_Homo sapiens_hsa051691.19467043
36Pyruvate metabolism_Homo sapiens_hsa006201.17631856
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.16994221
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11919956
39Vitamin B6 metabolism_Homo sapiens_hsa007501.08298335
40Sulfur relay system_Homo sapiens_hsa041221.02792831
41Graft-versus-host disease_Homo sapiens_hsa053321.00879148
42Cardiac muscle contraction_Homo sapiens_hsa042601.00523741
43Peroxisome_Homo sapiens_hsa041460.98273284
44Butanoate metabolism_Homo sapiens_hsa006500.97431960
45Primary immunodeficiency_Homo sapiens_hsa053400.95730948
46Antigen processing and presentation_Homo sapiens_hsa046120.92050138
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91670776
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91479824
49Glutathione metabolism_Homo sapiens_hsa004800.90627256
50Herpes simplex infection_Homo sapiens_hsa051680.90382517
51Allograft rejection_Homo sapiens_hsa053300.90113185
52mRNA surveillance pathway_Homo sapiens_hsa030150.88657083
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85230924
54Legionellosis_Homo sapiens_hsa051340.83603662
55Sulfur metabolism_Homo sapiens_hsa009200.80044663
56Pentose phosphate pathway_Homo sapiens_hsa000300.79493871
57Alzheimers disease_Homo sapiens_hsa050100.78233853
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.76480406
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75965686
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74809868
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.74533954
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71340704
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.69387515
64Systemic lupus erythematosus_Homo sapiens_hsa053220.67259452
65Arachidonic acid metabolism_Homo sapiens_hsa005900.66029739
66Measles_Homo sapiens_hsa051620.64842052
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64757126
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.61875133
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61504883
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.60618457
71Nicotine addiction_Homo sapiens_hsa050330.60360617
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59590390
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59428036
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58019425
75Shigellosis_Homo sapiens_hsa051310.57581499
76beta-Alanine metabolism_Homo sapiens_hsa004100.57063231
77Collecting duct acid secretion_Homo sapiens_hsa049660.56668308
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56006263
79Caffeine metabolism_Homo sapiens_hsa002320.54636862
80Basal cell carcinoma_Homo sapiens_hsa052170.53321231
81Regulation of autophagy_Homo sapiens_hsa041400.52660286
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51980256
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51871011
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51275498
85Oocyte meiosis_Homo sapiens_hsa041140.50802897
86Retinol metabolism_Homo sapiens_hsa008300.50164129
87Hematopoietic cell lineage_Homo sapiens_hsa046400.49894570
88Asthma_Homo sapiens_hsa053100.48855845
89Tryptophan metabolism_Homo sapiens_hsa003800.48752371
90Hedgehog signaling pathway_Homo sapiens_hsa043400.48446694
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48239770
92Viral carcinogenesis_Homo sapiens_hsa052030.48080939
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46721214
94Autoimmune thyroid disease_Homo sapiens_hsa053200.46245745
95Hippo signaling pathway_Homo sapiens_hsa043900.45584075
96HTLV-I infection_Homo sapiens_hsa051660.45409453
97Metabolic pathways_Homo sapiens_hsa011000.44849391
98Nitrogen metabolism_Homo sapiens_hsa009100.44545490
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44165368
100Leishmaniasis_Homo sapiens_hsa051400.43486649
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43370459
102Apoptosis_Homo sapiens_hsa042100.43170719
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39690039
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39612716
105Olfactory transduction_Homo sapiens_hsa047400.39429337
106Vitamin digestion and absorption_Homo sapiens_hsa049770.39145362
107Biosynthesis of amino acids_Homo sapiens_hsa012300.39142093
108Wnt signaling pathway_Homo sapiens_hsa043100.36427728
109Chemical carcinogenesis_Homo sapiens_hsa052040.35703223
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35283539
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34533121
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.33846775
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.33630195
114Influenza A_Homo sapiens_hsa051640.33279710
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31291333
116Linoleic acid metabolism_Homo sapiens_hsa005910.30734656
117Other glycan degradation_Homo sapiens_hsa005110.30657178
118Selenocompound metabolism_Homo sapiens_hsa004500.30396695
119Rheumatoid arthritis_Homo sapiens_hsa053230.29821519
120Malaria_Homo sapiens_hsa051440.29466460
121Hepatitis B_Homo sapiens_hsa051610.29359709
122Thyroid cancer_Homo sapiens_hsa052160.27884929
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27168735
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25730096
125Fructose and mannose metabolism_Homo sapiens_hsa000510.24984597
126Circadian rhythm_Homo sapiens_hsa047100.24851125
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23712369
128Fatty acid metabolism_Homo sapiens_hsa012120.22801829
129N-Glycan biosynthesis_Homo sapiens_hsa005100.22337576
130Phototransduction_Homo sapiens_hsa047440.22191828
131Taste transduction_Homo sapiens_hsa047420.21099793
132Ether lipid metabolism_Homo sapiens_hsa005650.20164589
133Pertussis_Homo sapiens_hsa051330.19894053
134Alcoholism_Homo sapiens_hsa050340.19175791
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.18904664
136Phagosome_Homo sapiens_hsa041450.18232386
137Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.17656682
138Carbon metabolism_Homo sapiens_hsa012000.17553000
139Type I diabetes mellitus_Homo sapiens_hsa049400.16159104
140Arginine and proline metabolism_Homo sapiens_hsa003300.16149074
141TGF-beta signaling pathway_Homo sapiens_hsa043500.14823268
142Sphingolipid metabolism_Homo sapiens_hsa006000.13482768
143Viral myocarditis_Homo sapiens_hsa054160.13046221
144Jak-STAT signaling pathway_Homo sapiens_hsa046300.12644565

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