

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit assembly (GO:0000028) | 6.30550800 |
| 2 | DNA deamination (GO:0045006) | 5.28617603 |
| 3 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.18198170 |
| 4 | ribosomal small subunit biogenesis (GO:0042274) | 5.05879258 |
| 5 | proteasome assembly (GO:0043248) | 4.83450950 |
| 6 | viral transcription (GO:0019083) | 4.81439278 |
| 7 | translational termination (GO:0006415) | 4.63787562 |
| 8 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 4.45233402 |
| 9 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.41224136 |
| 10 | termination of RNA polymerase III transcription (GO:0006386) | 4.37394150 |
| 11 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.37394150 |
| 12 | maturation of SSU-rRNA (GO:0030490) | 4.36762764 |
| 13 | behavioral response to nicotine (GO:0035095) | 4.30963221 |
| 14 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.23488760 |
| 15 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.22450330 |
| 16 | ribosomal large subunit biogenesis (GO:0042273) | 4.22144662 |
| 17 | cotranslational protein targeting to membrane (GO:0006613) | 4.21851330 |
| 18 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.20039107 |
| 19 | protein targeting to ER (GO:0045047) | 4.13231933 |
| 20 | translational elongation (GO:0006414) | 4.02327033 |
| 21 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.97246581 |
| 22 | protein localization to endoplasmic reticulum (GO:0070972) | 3.96884201 |
| 23 | protein complex biogenesis (GO:0070271) | 3.95220597 |
| 24 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.95005842 |
| 25 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.95005842 |
| 26 | NADH dehydrogenase complex assembly (GO:0010257) | 3.95005842 |
| 27 | cullin deneddylation (GO:0010388) | 3.91078693 |
| 28 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.90503231 |
| 29 | formation of translation preinitiation complex (GO:0001731) | 3.90432259 |
| 30 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.89994154 |
| 31 | ATP synthesis coupled proton transport (GO:0015986) | 3.89994154 |
| 32 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.89097976 |
| 33 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.89097976 |
| 34 | negative regulation of ligase activity (GO:0051352) | 3.88523307 |
| 35 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.88523307 |
| 36 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.86661742 |
| 37 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.86192783 |
| 38 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.86192783 |
| 39 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.86192783 |
| 40 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.82301750 |
| 41 | viral life cycle (GO:0019058) | 3.76941838 |
| 42 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.76612250 |
| 43 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.75950433 |
| 44 | respiratory chain complex IV assembly (GO:0008535) | 3.75432861 |
| 45 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.71619828 |
| 46 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.71619828 |
| 47 | cellular protein complex disassembly (GO:0043624) | 3.71344243 |
| 48 | DNA replication checkpoint (GO:0000076) | 3.71311480 |
| 49 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.70819510 |
| 50 | protein neddylation (GO:0045116) | 3.69617837 |
| 51 | translational initiation (GO:0006413) | 3.69271707 |
| 52 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.68843146 |
| 53 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.68233533 |
| 54 | chaperone-mediated protein transport (GO:0072321) | 3.67850674 |
| 55 | 7-methylguanosine mRNA capping (GO:0006370) | 3.67718892 |
| 56 | 7-methylguanosine RNA capping (GO:0009452) | 3.67006020 |
| 57 | RNA capping (GO:0036260) | 3.67006020 |
| 58 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.66673483 |
| 59 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.66542028 |
| 60 | translation (GO:0006412) | 3.66215224 |
| 61 | protein deneddylation (GO:0000338) | 3.64191761 |
| 62 | pseudouridine synthesis (GO:0001522) | 3.64168652 |
| 63 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.54710126 |
| 64 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.52895699 |
| 65 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.52895699 |
| 66 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.52367056 |
| 67 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.51686542 |
| 68 | peptidyl-histidine modification (GO:0018202) | 3.49975869 |
| 69 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.49794747 |
| 70 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.46053953 |
| 71 | UTP biosynthetic process (GO:0006228) | 3.45629501 |
| 72 | regulation of mitochondrial translation (GO:0070129) | 3.45183165 |
| 73 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.42588361 |
| 74 | cellular component biogenesis (GO:0044085) | 3.39591330 |
| 75 | DNA strand elongation (GO:0022616) | 3.37150863 |
| 76 | cytochrome complex assembly (GO:0017004) | 3.36060802 |
| 77 | L-methionine salvage (GO:0071267) | 3.36059566 |
| 78 | L-methionine biosynthetic process (GO:0071265) | 3.36059566 |
| 79 | amino acid salvage (GO:0043102) | 3.36059566 |
| 80 | protein targeting to mitochondrion (GO:0006626) | 3.36053527 |
| 81 | chromatin remodeling at centromere (GO:0031055) | 3.32820609 |
| 82 | metallo-sulfur cluster assembly (GO:0031163) | 3.32806511 |
| 83 | iron-sulfur cluster assembly (GO:0016226) | 3.32806511 |
| 84 | telomere maintenance via recombination (GO:0000722) | 3.28175815 |
| 85 | establishment of protein localization to mitochondrion (GO:0072655) | 3.25132137 |
| 86 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.21760072 |
| 87 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.21033892 |
| 88 | rRNA processing (GO:0006364) | 3.20950092 |
| 89 | respiratory electron transport chain (GO:0022904) | 3.17868225 |
| 90 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.16785779 |
| 91 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.16197097 |
| 92 | rRNA modification (GO:0000154) | 3.14645119 |
| 93 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.14307381 |
| 94 | positive regulation of ligase activity (GO:0051351) | 3.13633825 |
| 95 | viral mRNA export from host cell nucleus (GO:0046784) | 3.12784051 |
| 96 | CENP-A containing nucleosome assembly (GO:0034080) | 3.12458966 |
| 97 | replication fork processing (GO:0031297) | 3.11222633 |
| 98 | protein complex disassembly (GO:0043241) | 3.10271293 |
| 99 | electron transport chain (GO:0022900) | 3.09576912 |
| 100 | establishment of integrated proviral latency (GO:0075713) | 3.07928898 |
| 101 | transcription from RNA polymerase I promoter (GO:0006360) | 3.07172677 |
| 102 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.06509603 |
| 103 | termination of RNA polymerase I transcription (GO:0006363) | 3.05209452 |
| 104 | UTP metabolic process (GO:0046051) | 3.04642312 |
| 105 | rRNA metabolic process (GO:0016072) | 3.03848525 |
| 106 | macromolecular complex disassembly (GO:0032984) | 3.02955637 |
| 107 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.02521482 |
| 108 | positive regulation of cell cycle arrest (GO:0071158) | 3.02272184 |
| 109 | protein localization to mitochondrion (GO:0070585) | 3.02143560 |
| 110 | protein-cofactor linkage (GO:0018065) | 3.02104177 |
| 111 | base-excision repair, AP site formation (GO:0006285) | 3.01851222 |
| 112 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.01336794 |
| 113 | oxidative phosphorylation (GO:0006119) | 3.01228675 |
| 114 | tRNA processing (GO:0008033) | 3.00446064 |
| 115 | GTP biosynthetic process (GO:0006183) | 2.98233977 |
| 116 | CTP biosynthetic process (GO:0006241) | 2.94696047 |
| 117 | CTP metabolic process (GO:0046036) | 2.94696047 |
| 118 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.93438313 |
| 119 | maturation of 5.8S rRNA (GO:0000460) | 2.92259203 |
| 120 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.91921965 |
| 121 | establishment of viral latency (GO:0019043) | 2.91408831 |
| 122 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.90992302 |
| 123 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 2.90309410 |
| 124 | kynurenine metabolic process (GO:0070189) | 2.89620097 |
| 125 | guanosine-containing compound biosynthetic process (GO:1901070) | 2.87231395 |
| 126 | tRNA modification (GO:0006400) | 2.87125552 |
| 127 | intracellular protein transmembrane import (GO:0044743) | 2.84744583 |
| 128 | pyrimidine nucleotide catabolic process (GO:0006244) | 2.83601695 |
| 129 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 2.83276711 |
| 130 | mitochondrial RNA metabolic process (GO:0000959) | 2.83091769 |
| 131 | inner mitochondrial membrane organization (GO:0007007) | 2.82225631 |
| 132 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 2.74474102 |
| 133 | mannosylation (GO:0097502) | 2.73414964 |
| 134 | protein K6-linked ubiquitination (GO:0085020) | 2.73003868 |
| 135 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 2.72224292 |
| 136 | negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244) | 2.71779453 |
| 137 | spliceosomal snRNP assembly (GO:0000387) | 2.70500630 |
| 138 | RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502) | 2.68303497 |
| 139 | kinetochore assembly (GO:0051382) | 2.68209180 |
| 140 | ncRNA processing (GO:0034470) | 2.67350976 |
| 141 | ATP biosynthetic process (GO:0006754) | 2.66988936 |
| 142 | DNA damage response, detection of DNA damage (GO:0042769) | 2.66877317 |
| 143 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 2.64572057 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.61348984 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.27363464 |
| 3 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 4.25268692 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.22371632 |
| 5 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.09982039 |
| 6 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 4.09164332 |
| 7 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.84347318 |
| 8 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.65301941 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.59164677 |
| 10 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.37199794 |
| 11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.28275758 |
| 12 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.24426102 |
| 13 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.20821598 |
| 14 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 3.07170295 |
| 15 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.00706195 |
| 16 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.99950031 |
| 17 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.96034841 |
| 18 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.73268964 |
| 19 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.72113900 |
| 20 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.60877038 |
| 21 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.60149440 |
| 22 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.59035987 |
| 23 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.58251892 |
| 24 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.49346618 |
| 25 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.39237023 |
| 26 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.37433917 |
| 27 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.35892387 |
| 28 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.30988617 |
| 29 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.27592014 |
| 30 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.27340997 |
| 31 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.27108369 |
| 32 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.24387434 |
| 33 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 2.14347015 |
| 34 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.10061327 |
| 35 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 2.01027810 |
| 36 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.00969455 |
| 37 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.00719005 |
| 38 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.98242755 |
| 39 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.96528719 |
| 40 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.93940154 |
| 41 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.89736621 |
| 42 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.87619705 |
| 43 | * ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.86422243 |
| 44 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.76852575 |
| 45 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.73262612 |
| 46 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.72596096 |
| 47 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.69357920 |
| 48 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.67218024 |
| 49 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.65471729 |
| 50 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.61485753 |
| 51 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.60066473 |
| 52 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.59533290 |
| 53 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.56556565 |
| 54 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.56261286 |
| 55 | * CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.54998043 |
| 56 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.51710501 |
| 57 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.49353532 |
| 58 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.48860782 |
| 59 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.42214380 |
| 60 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.37247763 |
| 61 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.37225402 |
| 62 | * CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.36569279 |
| 63 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.36370309 |
| 64 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.32164247 |
| 65 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.31320267 |
| 66 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.28305814 |
| 67 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.23204407 |
| 68 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.20067306 |
| 69 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.18900812 |
| 70 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.18553328 |
| 71 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.17704653 |
| 72 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.16110045 |
| 73 | * SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.14763237 |
| 74 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.14228734 |
| 75 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.13569212 |
| 76 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.12225735 |
| 77 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.11876988 |
| 78 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.11373384 |
| 79 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.10224315 |
| 80 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.08491053 |
| 81 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.07389775 |
| 82 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.07340191 |
| 83 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.07024585 |
| 84 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.05401450 |
| 85 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.04370616 |
| 86 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.03737661 |
| 87 | * TFEB_21752829_ChIP-Seq_HELA_Human | 1.03709330 |
| 88 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.02820748 |
| 89 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.02345322 |
| 90 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.02219014 |
| 91 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.02190067 |
| 92 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.99874616 |
| 93 | ERA_21632823_ChIP-Seq_H3396_Human | 0.99642408 |
| 94 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.98840288 |
| 95 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.98465025 |
| 96 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.97474732 |
| 97 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.97449961 |
| 98 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.97212083 |
| 99 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.96410050 |
| 100 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.92269656 |
| 101 | VDR_22108803_ChIP-Seq_LS180_Human | 0.92182630 |
| 102 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.91605885 |
| 103 | EWS_26573619_Chip-Seq_HEK293_Human | 0.91210419 |
| 104 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 0.89780070 |
| 105 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.89377104 |
| 106 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.88334789 |
| 107 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.87919018 |
| 108 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.87644297 |
| 109 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.86844799 |
| 110 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.85892127 |
| 111 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.85386564 |
| 112 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.84087135 |
| 113 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.83598658 |
| 114 | PHF8_20622854_ChIP-Seq_HELA_Human | 0.83324025 |
| 115 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.83117061 |
| 116 | * E2F1_20622854_ChIP-Seq_HELA_Human | 0.82922911 |
| 117 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 0.82887661 |
| 118 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.80670023 |
| 119 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.79330813 |
| 120 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.78051871 |
| 121 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.77253862 |
| 122 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.77021757 |
| 123 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.75731014 |
| 124 | * OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.73007973 |
| 125 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.72609338 |
| 126 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.71456615 |
| 127 | * SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.71066304 |
| 128 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.67327519 |
| 129 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.67015672 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 3.01086340 |
| 2 | MP0009379_abnormal_foot_pigmentation | 2.98724287 |
| 3 | MP0008058_abnormal_DNA_repair | 2.87370990 |
| 4 | MP0005671_abnormal_response_to | 2.85010628 |
| 5 | MP0001835_abnormal_antigen_presentation | 2.84646441 |
| 6 | MP0002837_dystrophic_cardiac_calcinosis | 2.83087215 |
| 7 | MP0004957_abnormal_blastocyst_morpholog | 2.71573017 |
| 8 | MP0003646_muscle_fatigue | 2.60689391 |
| 9 | MP0010094_abnormal_chromosome_stability | 2.58954159 |
| 10 | MP0002148_abnormal_hypersensitivity_rea | 2.42758060 |
| 11 | MP0009785_altered_susceptibility_to | 2.41552227 |
| 12 | MP0010030_abnormal_orbit_morphology | 2.36877845 |
| 13 | MP0003077_abnormal_cell_cycle | 2.28010485 |
| 14 | MP0005646_abnormal_pituitary_gland | 2.18853108 |
| 15 | MP0008057_abnormal_DNA_replication | 2.11124490 |
| 16 | MP0003186_abnormal_redox_activity | 2.10464268 |
| 17 | MP0009333_abnormal_splenocyte_physiolog | 2.09102528 |
| 18 | MP0001986_abnormal_taste_sensitivity | 2.08546547 |
| 19 | MP0003806_abnormal_nucleotide_metabolis | 2.06874880 |
| 20 | MP0003111_abnormal_nucleus_morphology | 2.04111951 |
| 21 | MP0002160_abnormal_reproductive_system | 2.02407074 |
| 22 | MP0005075_abnormal_melanosome_morpholog | 2.01583982 |
| 23 | MP0006292_abnormal_olfactory_placode | 2.01532793 |
| 24 | MP0008007_abnormal_cellular_replicative | 1.99816452 |
| 25 | MP0001529_abnormal_vocalization | 1.96494039 |
| 26 | MP0003195_calcinosis | 1.94082836 |
| 27 | MP0000685_abnormal_immune_system | 1.93939283 |
| 28 | MP0003763_abnormal_thymus_physiology | 1.91378230 |
| 29 | MP0005025_abnormal_response_to | 1.88380198 |
| 30 | MP0001800_abnormal_humoral_immune | 1.85347346 |
| 31 | MP0000049_abnormal_middle_ear | 1.84563459 |
| 32 | MP0005000_abnormal_immune_tolerance | 1.84067765 |
| 33 | MP0003786_premature_aging | 1.83674081 |
| 34 | MP0008932_abnormal_embryonic_tissue | 1.79349744 |
| 35 | MP0002420_abnormal_adaptive_immunity | 1.79094976 |
| 36 | MP0002132_abnormal_respiratory_system | 1.78399173 |
| 37 | MP0002723_abnormal_immune_serum | 1.77748915 |
| 38 | MP0001819_abnormal_immune_cell | 1.77544590 |
| 39 | MP0003880_abnormal_central_pattern | 1.76240960 |
| 40 | MP0002452_abnormal_antigen_presenting | 1.73475789 |
| 41 | MP0002102_abnormal_ear_morphology | 1.71419690 |
| 42 | MP0001905_abnormal_dopamine_level | 1.71399779 |
| 43 | MP0006072_abnormal_retinal_apoptosis | 1.70112222 |
| 44 | MP0002396_abnormal_hematopoietic_system | 1.67752099 |
| 45 | MP0008789_abnormal_olfactory_epithelium | 1.67021331 |
| 46 | MP0002653_abnormal_ependyma_morphology | 1.65624976 |
| 47 | MP0002398_abnormal_bone_marrow | 1.65045296 |
| 48 | MP0001853_heart_inflammation | 1.62185606 |
| 49 | MP0005389_reproductive_system_phenotype | 1.59141022 |
| 50 | MP0001188_hyperpigmentation | 1.58464908 |
| 51 | MP0005551_abnormal_eye_electrophysiolog | 1.56327414 |
| 52 | MP0000631_abnormal_neuroendocrine_gland | 1.55637628 |
| 53 | MP0005387_immune_system_phenotype | 1.55359952 |
| 54 | MP0001790_abnormal_immune_system | 1.55359952 |
| 55 | MP0000716_abnormal_immune_system | 1.54484375 |
| 56 | MP0008260_abnormal_autophagy | 1.53602549 |
| 57 | MP0009053_abnormal_anal_canal | 1.51540731 |
| 58 | MP0006036_abnormal_mitochondrial_physio | 1.49604654 |
| 59 | MP0003718_maternal_effect | 1.48784863 |
| 60 | MP0000689_abnormal_spleen_morphology | 1.45329704 |
| 61 | MP0004142_abnormal_muscle_tone | 1.45108273 |
| 62 | MP0002419_abnormal_innate_immunity | 1.41972844 |
| 63 | MP0001348_abnormal_lacrimal_gland | 1.41414833 |
| 64 | MP0002429_abnormal_blood_cell | 1.40985135 |
| 65 | MP0008872_abnormal_physiological_respon | 1.40936945 |
| 66 | MP0005670_abnormal_white_adipose | 1.40311702 |
| 67 | MP0005379_endocrine/exocrine_gland_phen | 1.38540664 |
| 68 | MP0002722_abnormal_immune_system | 1.35235592 |
| 69 | MP0000490_abnormal_crypts_of | 1.32885137 |
| 70 | MP0001293_anophthalmia | 1.31275169 |
| 71 | MP0008875_abnormal_xenobiotic_pharmacok | 1.31266052 |
| 72 | MP0003724_increased_susceptibility_to | 1.30795028 |
| 73 | MP0004147_increased_porphyrin_level | 1.28465693 |
| 74 | MP0006082_CNS_inflammation | 1.28034792 |
| 75 | MP0002736_abnormal_nociception_after | 1.24274788 |
| 76 | MP0002405_respiratory_system_inflammati | 1.23969789 |
| 77 | MP0002638_abnormal_pupillary_reflex | 1.20224767 |
| 78 | MP0003937_abnormal_limbs/digits/tail_de | 1.19698252 |
| 79 | MP0000313_abnormal_cell_death | 1.18674593 |
| 80 | MP0001919_abnormal_reproductive_system | 1.17717783 |
| 81 | MP0005174_abnormal_tail_pigmentation | 1.15804404 |
| 82 | MP0005332_abnormal_amino_acid | 1.14376756 |
| 83 | MP0004381_abnormal_hair_follicle | 1.13503699 |
| 84 | MP0000372_irregular_coat_pigmentation | 1.11679236 |
| 85 | MP0000537_abnormal_urethra_morphology | 1.10678524 |
| 86 | MP0003283_abnormal_digestive_organ | 1.10240739 |
| 87 | MP0002210_abnormal_sex_determination | 1.09618482 |
| 88 | MP0000465_gastrointestinal_hemorrhage | 1.09473921 |
| 89 | MP0000920_abnormal_myelination | 1.08653913 |
| 90 | MP0005253_abnormal_eye_physiology | 1.07872708 |
| 91 | MP0008995_early_reproductive_senescence | 1.07813524 |
| 92 | MP0006035_abnormal_mitochondrial_morpho | 1.06042497 |
| 93 | MP0003011_delayed_dark_adaptation | 1.05402502 |
| 94 | MP0009046_muscle_twitch | 1.05076946 |
| 95 | MP0000703_abnormal_thymus_morphology | 1.03771473 |
| 96 | MP0000015_abnormal_ear_pigmentation | 1.03621162 |
| 97 | MP0003436_decreased_susceptibility_to | 1.03082872 |
| 98 | MP0009250_abnormal_appendicular_skeleto | 1.02962683 |
| 99 | MP0005084_abnormal_gallbladder_morpholo | 1.02889660 |
| 100 | MP0009840_abnormal_foam_cell | 1.01549188 |
| 101 | MP0002234_abnormal_pharynx_morphology | 1.01406663 |
| 102 | MP0005360_urolithiasis | 1.00826402 |
| 103 | MP0002277_abnormal_respiratory_mucosa | 1.00749261 |
| 104 | MP0008877_abnormal_DNA_methylation | 0.99494697 |
| 105 | MP0002019_abnormal_tumor_incidence | 0.98800548 |
| 106 | MP0004133_heterotaxia | 0.98403577 |
| 107 | MP0002095_abnormal_skin_pigmentation | 0.98108361 |
| 108 | MP0000026_abnormal_inner_ear | 0.97488330 |
| 109 | MP0003938_abnormal_ear_development | 0.97012243 |
| 110 | MP0005171_absent_coat_pigmentation | 0.96047698 |
| 111 | MP0005195_abnormal_posterior_eye | 0.95847594 |
| 112 | MP0001145_abnormal_male_reproductive | 0.94650925 |
| 113 | MP0004145_abnormal_muscle_electrophysio | 0.94208513 |
| 114 | MP0003119_abnormal_digestive_system | 0.93039179 |
| 115 | MP0000538_abnormal_urinary_bladder | 0.91909685 |
| 116 | MP0005397_hematopoietic_system_phenotyp | 0.91479438 |
| 117 | MP0001545_abnormal_hematopoietic_system | 0.91479438 |
| 118 | MP0002249_abnormal_larynx_morphology | 0.90364726 |
| 119 | MP0008004_abnormal_stomach_pH | 0.88840468 |
| 120 | MP0003136_yellow_coat_color | 0.88436200 |
| 121 | MP0005377_hearing/vestibular/ear_phenot | 0.87715572 |
| 122 | MP0003878_abnormal_ear_physiology | 0.87715572 |
| 123 | MP0001845_abnormal_inflammatory_respons | 0.87045928 |
| 124 | MP0001968_abnormal_touch/_nociception | 0.86519007 |
| 125 | MP0001324_abnormal_eye_pigmentation | 0.86254859 |
| 126 | MP0005408_hypopigmentation | 0.85280440 |
| 127 | MP0000681_abnormal_thyroid_gland | 0.85031046 |
| 128 | MP0000653_abnormal_sex_gland | 0.84947572 |
| 129 | MP0003315_abnormal_perineum_morphology | 0.84947309 |
| 130 | MP0002876_abnormal_thyroid_physiology | 0.84133636 |
| 131 | MP0005499_abnormal_olfactory_system | 0.83990605 |
| 132 | MP0005394_taste/olfaction_phenotype | 0.83990605 |
| 133 | MP0003567_abnormal_fetal_cardiomyocyte | 0.83391786 |
| 134 | MP0003942_abnormal_urinary_system | 0.83313900 |
| 135 | MP0001764_abnormal_homeostasis | 0.82615607 |
| 136 | MP0002751_abnormal_autonomic_nervous | 0.82562674 |
| 137 | MP0003866_abnormal_defecation | 0.82546975 |
| 138 | MP0002163_abnormal_gland_morphology | 0.81549462 |
| 139 | MP0005310_abnormal_salivary_gland | 0.81248539 |
| 140 | MP0002735_abnormal_chemical_nociception | 0.80786609 |
| 141 | MP0008469_abnormal_protein_level | 0.79286599 |
| 142 | MP0001963_abnormal_hearing_physiology | 0.78720155 |
| 143 | MP0001485_abnormal_pinna_reflex | 0.78081814 |
| 144 | MP0004742_abnormal_vestibular_system | 0.76688012 |
| 145 | MP0000858_altered_metastatic_potential | 0.76318650 |
| 146 | MP0010155_abnormal_intestine_physiology | 0.75543666 |
| 147 | MP0001929_abnormal_gametogenesis | 0.75481242 |
| 148 | MP0005410_abnormal_fertilization | 0.74527726 |
| 149 | MP0005409_darkened_coat_color | 0.74338989 |
| 150 | MP0003950_abnormal_plasma_membrane | 0.74035706 |
| 151 | MP0000358_abnormal_cell_content/ | 0.72350098 |
| 152 | MP0002938_white_spotting | 0.72330151 |
| 153 | MP0002272_abnormal_nervous_system | 0.71734417 |
| 154 | MP0005391_vision/eye_phenotype | 0.70902072 |
| 155 | MP0009697_abnormal_copulation | 0.70068814 |
| 156 | MP0009745_abnormal_behavioral_response | 0.69889752 |
| 157 | MP0001119_abnormal_female_reproductive | 0.68971583 |
| 158 | MP0002752_abnormal_somatic_nervous | 0.68848034 |
| 159 | MP0002557_abnormal_social/conspecific_i | 0.64880857 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.61302523 |
| 2 | Mitochondrial inheritance (HP:0001427) | 4.60486099 |
| 3 | Hepatocellular necrosis (HP:0001404) | 4.53554008 |
| 4 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.27270584 |
| 5 | 3-Methylglutaconic aciduria (HP:0003535) | 4.20558990 |
| 6 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.19493007 |
| 7 | Abnormal number of erythroid precursors (HP:0012131) | 4.05374115 |
| 8 | Increased CSF lactate (HP:0002490) | 4.01762640 |
| 9 | Reticulocytopenia (HP:0001896) | 3.95030462 |
| 10 | Hepatic necrosis (HP:0002605) | 3.91638096 |
| 11 | Increased hepatocellular lipid droplets (HP:0006565) | 3.90266135 |
| 12 | Acute encephalopathy (HP:0006846) | 3.68312732 |
| 13 | Cerebral hypomyelination (HP:0006808) | 3.60487417 |
| 14 | Progressive macrocephaly (HP:0004481) | 3.59221891 |
| 15 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.57712235 |
| 16 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.55897075 |
| 17 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.55897075 |
| 18 | Type I transferrin isoform profile (HP:0003642) | 3.50295244 |
| 19 | Renal Fanconi syndrome (HP:0001994) | 3.46090428 |
| 20 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.37667108 |
| 21 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 3.36424524 |
| 22 | Increased serum lactate (HP:0002151) | 3.33130690 |
| 23 | Lipid accumulation in hepatocytes (HP:0006561) | 3.32242037 |
| 24 | Increased serum pyruvate (HP:0003542) | 3.25594998 |
| 25 | Abnormality of glycolysis (HP:0004366) | 3.25594998 |
| 26 | Exertional dyspnea (HP:0002875) | 3.18539850 |
| 27 | Macrocytic anemia (HP:0001972) | 3.12193484 |
| 28 | Methylmalonic aciduria (HP:0012120) | 3.08551297 |
| 29 | Pendular nystagmus (HP:0012043) | 3.05959282 |
| 30 | Birth length less than 3rd percentile (HP:0003561) | 2.97862175 |
| 31 | Absent thumb (HP:0009777) | 2.93993076 |
| 32 | Pancreatic fibrosis (HP:0100732) | 2.91881034 |
| 33 | Increased intramyocellular lipid droplets (HP:0012240) | 2.91705952 |
| 34 | Pallor (HP:0000980) | 2.81989780 |
| 35 | Lactic acidosis (HP:0003128) | 2.73352867 |
| 36 | Microvesicular hepatic steatosis (HP:0001414) | 2.72961154 |
| 37 | Aplastic anemia (HP:0001915) | 2.72784451 |
| 38 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.71543049 |
| 39 | Respiratory failure (HP:0002878) | 2.70044693 |
| 40 | Congenital, generalized hypertrichosis (HP:0004540) | 2.65428048 |
| 41 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.63282328 |
| 42 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.63282328 |
| 43 | Abnormal protein glycosylation (HP:0012346) | 2.63282328 |
| 44 | Abnormal glycosylation (HP:0012345) | 2.63282328 |
| 45 | Methylmalonic acidemia (HP:0002912) | 2.62202596 |
| 46 | Exercise intolerance (HP:0003546) | 2.61171718 |
| 47 | True hermaphroditism (HP:0010459) | 2.59953869 |
| 48 | Congenital stationary night blindness (HP:0007642) | 2.58740091 |
| 49 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.53801719 |
| 50 | Leukodystrophy (HP:0002415) | 2.51580854 |
| 51 | Abnormality of midbrain morphology (HP:0002418) | 2.51214506 |
| 52 | Molar tooth sign on MRI (HP:0002419) | 2.51214506 |
| 53 | Chromsome breakage (HP:0040012) | 2.45883343 |
| 54 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.43378908 |
| 55 | Respiratory difficulties (HP:0002880) | 2.42275637 |
| 56 | Reduced antithrombin III activity (HP:0001976) | 2.42005153 |
| 57 | IgG deficiency (HP:0004315) | 2.34638583 |
| 58 | Hyperglycinemia (HP:0002154) | 2.33395003 |
| 59 | B lymphocytopenia (HP:0010976) | 2.32383290 |
| 60 | Abnormality of B cell number (HP:0010975) | 2.32383290 |
| 61 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.31466777 |
| 62 | IgM deficiency (HP:0002850) | 2.31012683 |
| 63 | Sclerocornea (HP:0000647) | 2.30925341 |
| 64 | Increased muscle lipid content (HP:0009058) | 2.29528383 |
| 65 | Abnormality of renal resorption (HP:0011038) | 2.29374836 |
| 66 | Breast hypoplasia (HP:0003187) | 2.27284738 |
| 67 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.26894430 |
| 68 | Optic disc pallor (HP:0000543) | 2.26591304 |
| 69 | Parakeratosis (HP:0001036) | 2.24229593 |
| 70 | Concave nail (HP:0001598) | 2.21111385 |
| 71 | Hepatosplenomegaly (HP:0001433) | 2.20908651 |
| 72 | Poor head control (HP:0002421) | 2.20013281 |
| 73 | Nephronophthisis (HP:0000090) | 2.19049298 |
| 74 | Cleft eyelid (HP:0000625) | 2.17034639 |
| 75 | Patellar aplasia (HP:0006443) | 2.16521638 |
| 76 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.15244845 |
| 77 | Recurrent abscess formation (HP:0002722) | 2.15189331 |
| 78 | Abnormal hair whorl (HP:0010721) | 2.14256746 |
| 79 | Triphalangeal thumb (HP:0001199) | 2.13724599 |
| 80 | Cerebral edema (HP:0002181) | 2.13065228 |
| 81 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.12178555 |
| 82 | Abnormal number of incisors (HP:0011064) | 2.11441286 |
| 83 | Abnormality of DNA repair (HP:0003254) | 2.11322468 |
| 84 | Premature graying of hair (HP:0002216) | 2.10952001 |
| 85 | Pancytopenia (HP:0001876) | 2.10777364 |
| 86 | Type 2 muscle fiber atrophy (HP:0003554) | 2.08733514 |
| 87 | Agnosia (HP:0010524) | 2.08536701 |
| 88 | Rough bone trabeculation (HP:0100670) | 2.08392507 |
| 89 | Emotional lability (HP:0000712) | 2.08386563 |
| 90 | Abnormality of alanine metabolism (HP:0010916) | 2.07522505 |
| 91 | Hyperalaninemia (HP:0003348) | 2.07522505 |
| 92 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.07522505 |
| 93 | CNS demyelination (HP:0007305) | 2.06861291 |
| 94 | Muscle fiber atrophy (HP:0100295) | 2.04568395 |
| 95 | Lethargy (HP:0001254) | 2.04098827 |
| 96 | Dicarboxylic aciduria (HP:0003215) | 2.03402375 |
| 97 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.03402375 |
| 98 | Asplenia (HP:0001746) | 2.01663183 |
| 99 | Hypoplasia of the pons (HP:0012110) | 2.01141914 |
| 100 | Cutaneous melanoma (HP:0012056) | 2.00780706 |
| 101 | Type II lissencephaly (HP:0007260) | 1.99463587 |
| 102 | Opisthotonus (HP:0002179) | 1.98419353 |
| 103 | Ectopic kidney (HP:0000086) | 1.97666002 |
| 104 | Severe combined immunodeficiency (HP:0004430) | 1.97438804 |
| 105 | Oral leukoplakia (HP:0002745) | 1.95677702 |
| 106 | Short thumb (HP:0009778) | 1.95489394 |
| 107 | Abolished electroretinogram (ERG) (HP:0000550) | 1.94730273 |
| 108 | Anencephaly (HP:0002323) | 1.94100850 |
| 109 | Duplicated collecting system (HP:0000081) | 1.93580595 |
| 110 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.91917668 |
| 111 | Vacuolated lymphocytes (HP:0001922) | 1.91299263 |
| 112 | Lymphoma (HP:0002665) | 1.89054984 |
| 113 | Petechiae (HP:0000967) | 1.88285773 |
| 114 | Congenital ichthyosiform erythroderma (HP:0007431) | 1.88148021 |
| 115 | Bone marrow hypocellularity (HP:0005528) | 1.87772934 |
| 116 | Abnormal trabecular bone morphology (HP:0100671) | 1.87762616 |
| 117 | Horseshoe kidney (HP:0000085) | 1.86829163 |
| 118 | Abnormality of macrophages (HP:0004311) | 1.85835027 |
| 119 | Abnormality of cochlea (HP:0000375) | 1.85823640 |
| 120 | Abnormality of the pons (HP:0007361) | 1.85767261 |
| 121 | Increased IgM level (HP:0003496) | 1.85400549 |
| 122 | Colon cancer (HP:0003003) | 1.83833038 |
| 123 | Granulocytopenia (HP:0001913) | 1.82659035 |
| 124 | Cystic liver disease (HP:0006706) | 1.82394718 |
| 125 | Neutropenia (HP:0001875) | 1.82050780 |
| 126 | Septo-optic dysplasia (HP:0100842) | 1.81656951 |
| 127 | Abnormality of the preputium (HP:0100587) | 1.81492512 |
| 128 | Abnormality of serum amino acid levels (HP:0003112) | 1.80574767 |
| 129 | CNS hypomyelination (HP:0003429) | 1.80059553 |
| 130 | Thrombocytosis (HP:0001894) | 1.78529277 |
| 131 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 1.78274797 |
| 132 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 1.77368370 |
| 133 | Abnormality of the carotid arteries (HP:0005344) | 1.73997060 |
| 134 | Postnatal microcephaly (HP:0005484) | 1.72908158 |
| 135 | Hypoplasia of the radius (HP:0002984) | 1.72851606 |
| 136 | Abnormality of the renal collecting system (HP:0004742) | 1.71844349 |
| 137 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.71445157 |
| 138 | Severe visual impairment (HP:0001141) | 1.70504472 |
| 139 | Abnormality of chromosome stability (HP:0003220) | 1.69045433 |
| 140 | Abnormality of the ileum (HP:0001549) | 1.68940048 |
| 141 | Pancreatic cysts (HP:0001737) | 1.68741798 |
| 142 | Combined immunodeficiency (HP:0005387) | 1.67669470 |
| 143 | Medial flaring of the eyebrow (HP:0010747) | 1.66740048 |
| 144 | Microretrognathia (HP:0000308) | 1.65583837 |
| 145 | Meckel diverticulum (HP:0002245) | 1.65160259 |
| 146 | Pulmonary fibrosis (HP:0002206) | 1.63088646 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 4.67501949 |
| 2 | STK16 | 3.92227269 |
| 3 | FRK | 3.50162494 |
| 4 | NME2 | 3.36148793 |
| 5 | BUB1 | 3.24616985 |
| 6 | EIF2AK1 | 3.09568260 |
| 7 | MAP3K12 | 2.59081953 |
| 8 | PIM2 | 2.48919845 |
| 9 | VRK1 | 2.39974244 |
| 10 | TESK2 | 2.20018272 |
| 11 | MST4 | 2.19641892 |
| 12 | WEE1 | 2.12658667 |
| 13 | ARAF | 1.93495574 |
| 14 | CCNB1 | 1.93199840 |
| 15 | PBK | 1.88625499 |
| 16 | EIF2AK3 | 1.88018351 |
| 17 | MAP4K1 | 1.86759306 |
| 18 | SRPK1 | 1.83563157 |
| 19 | CDK19 | 1.78226489 |
| 20 | MAP4K2 | 1.71347085 |
| 21 | TLK1 | 1.68967775 |
| 22 | TXK | 1.66849767 |
| 23 | NUAK1 | 1.57465028 |
| 24 | TNIK | 1.56399331 |
| 25 | NME1 | 1.52411785 |
| 26 | NEK1 | 1.46910335 |
| 27 | TSSK6 | 1.44535835 |
| 28 | ADRBK2 | 1.42356429 |
| 29 | BRAF | 1.37425444 |
| 30 | CHEK2 | 1.36479076 |
| 31 | IRAK4 | 1.35024513 |
| 32 | WNK3 | 1.30927537 |
| 33 | CASK | 1.30471914 |
| 34 | MAP3K11 | 1.25712306 |
| 35 | KDR | 1.24335714 |
| 36 | PLK4 | 1.21130281 |
| 37 | WNK4 | 1.21116855 |
| 38 | SIK3 | 1.20715718 |
| 39 | INSRR | 1.19973729 |
| 40 | MKNK1 | 1.18156005 |
| 41 | BLK | 1.17414672 |
| 42 | BCR | 1.15838088 |
| 43 | PDK2 | 1.13404088 |
| 44 | MAP2K7 | 1.12177255 |
| 45 | NEK2 | 1.10289929 |
| 46 | TEC | 1.08900698 |
| 47 | OXSR1 | 1.06836110 |
| 48 | STK39 | 1.06457867 |
| 49 | PRPF4B | 1.05148957 |
| 50 | TAF1 | 1.04248852 |
| 51 | MAPKAPK3 | 1.04153004 |
| 52 | MUSK | 1.03089892 |
| 53 | BMPR1B | 1.01537834 |
| 54 | EIF2AK2 | 1.01075760 |
| 55 | MAP3K14 | 0.99317380 |
| 56 | AKT3 | 0.99108035 |
| 57 | GRK7 | 0.98761219 |
| 58 | KIT | 0.98617786 |
| 59 | TTK | 0.97199600 |
| 60 | YES1 | 0.96794912 |
| 61 | IKBKB | 0.96084898 |
| 62 | BRSK2 | 0.96069150 |
| 63 | SYK | 0.95578656 |
| 64 | CSNK1G3 | 0.92214732 |
| 65 | CDC7 | 0.91597154 |
| 66 | ACVR1B | 0.91366788 |
| 67 | TYK2 | 0.89277781 |
| 68 | DAPK1 | 0.89102402 |
| 69 | PRKCI | 0.87266574 |
| 70 | DYRK2 | 0.85716134 |
| 71 | CLK1 | 0.82467048 |
| 72 | EPHB2 | 0.76682053 |
| 73 | LYN | 0.76462578 |
| 74 | PLK1 | 0.75995874 |
| 75 | AURKA | 0.75993655 |
| 76 | CDK8 | 0.75464100 |
| 77 | ADRBK1 | 0.75226870 |
| 78 | CSNK1G2 | 0.73972164 |
| 79 | LIMK1 | 0.72525056 |
| 80 | TBK1 | 0.71228697 |
| 81 | TGFBR1 | 0.71038688 |
| 82 | BTK | 0.69475910 |
| 83 | BMPR2 | 0.69263970 |
| 84 | PINK1 | 0.68472138 |
| 85 | PRKCG | 0.65369439 |
| 86 | TAOK2 | 0.64738522 |
| 87 | ATR | 0.63139360 |
| 88 | MYLK | 0.62625867 |
| 89 | CSNK1G1 | 0.61613449 |
| 90 | DAPK3 | 0.60893378 |
| 91 | MKNK2 | 0.60302489 |
| 92 | ABL2 | 0.59912076 |
| 93 | MAPK15 | 0.59800487 |
| 94 | SCYL2 | 0.58893221 |
| 95 | RIPK4 | 0.58570474 |
| 96 | LCK | 0.57730352 |
| 97 | CSNK2A1 | 0.56951465 |
| 98 | IRAK3 | 0.56224824 |
| 99 | ZAP70 | 0.55549910 |
| 100 | MAP2K6 | 0.55350892 |
| 101 | MAPK13 | 0.54143331 |
| 102 | MAP2K2 | 0.54084191 |
| 103 | AURKB | 0.53871254 |
| 104 | CSNK2A2 | 0.52871298 |
| 105 | IKBKE | 0.50912927 |
| 106 | STK4 | 0.50840678 |
| 107 | CDK7 | 0.50323351 |
| 108 | ILK | 0.50228460 |
| 109 | RPS6KB2 | 0.49553692 |
| 110 | PASK | 0.49442235 |
| 111 | TESK1 | 0.49411402 |
| 112 | CSNK1A1 | 0.49055031 |
| 113 | BRSK1 | 0.48918651 |
| 114 | RPS6KA5 | 0.48768503 |
| 115 | PRKCD | 0.45486713 |
| 116 | CHEK1 | 0.45049675 |
| 117 | CSNK1A1L | 0.44580367 |
| 118 | GRK1 | 0.43477806 |
| 119 | PRKD2 | 0.41784214 |
| 120 | DYRK3 | 0.41476915 |
| 121 | PAK1 | 0.40996269 |
| 122 | PLK3 | 0.38989078 |
| 123 | PIM1 | 0.38962491 |
| 124 | GRK6 | 0.38021700 |
| 125 | CSF1R | 0.37986535 |
| 126 | MAPKAPK5 | 0.37562742 |
| 127 | TIE1 | 0.37064295 |
| 128 | ATM | 0.36836474 |
| 129 | MATK | 0.36115660 |
| 130 | ZAK | 0.35629459 |
| 131 | BCKDK | 0.34543447 |
| 132 | CDK11A | 0.34174029 |
| 133 | RPS6KA6 | 0.34127386 |
| 134 | FLT3 | 0.31155599 |
| 135 | CDK4 | 0.27001659 |
| 136 | PKN1 | 0.26765833 |
| 137 | CDK1 | 0.26561551 |
| 138 | CDK2 | 0.26163754 |
| 139 | PRKACA | 0.25443562 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 4.82659918 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 4.75106275 |
| 3 | RNA polymerase_Homo sapiens_hsa03020 | 3.84213313 |
| 4 | DNA replication_Homo sapiens_hsa03030 | 3.67423669 |
| 5 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.26153254 |
| 6 | Mismatch repair_Homo sapiens_hsa03430 | 2.96531554 |
| 7 | Parkinsons disease_Homo sapiens_hsa05012 | 2.76162583 |
| 8 | Homologous recombination_Homo sapiens_hsa03440 | 2.51702791 |
| 9 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.43284160 |
| 10 | Base excision repair_Homo sapiens_hsa03410 | 2.37655923 |
| 11 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.36960102 |
| 12 | Spliceosome_Homo sapiens_hsa03040 | 2.33940022 |
| 13 | Protein export_Homo sapiens_hsa03060 | 2.28929635 |
| 14 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.18285643 |
| 15 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.11196621 |
| 16 | Huntingtons disease_Homo sapiens_hsa05016 | 2.00330239 |
| 17 | Alzheimers disease_Homo sapiens_hsa05010 | 1.95962543 |
| 18 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.83138450 |
| 19 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.62079779 |
| 20 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.60626581 |
| 21 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.60197159 |
| 22 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.48508334 |
| 23 | Basal transcription factors_Homo sapiens_hsa03022 | 1.45680221 |
| 24 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.45502452 |
| 25 | Purine metabolism_Homo sapiens_hsa00230 | 1.44780923 |
| 26 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.44473218 |
| 27 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.44124543 |
| 28 | RNA transport_Homo sapiens_hsa03013 | 1.42270690 |
| 29 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.37801319 |
| 30 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.29083358 |
| 31 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.23339185 |
| 32 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.19543078 |
| 33 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.17562156 |
| 34 | RNA degradation_Homo sapiens_hsa03018 | 1.16510134 |
| 35 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.13650150 |
| 36 | Allograft rejection_Homo sapiens_hsa05330 | 1.12231777 |
| 37 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.06195598 |
| 38 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.03252796 |
| 39 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.02991014 |
| 40 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.99464318 |
| 41 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.96292121 |
| 42 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.94448567 |
| 43 | Cell cycle_Homo sapiens_hsa04110 | 0.93974628 |
| 44 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.90970541 |
| 45 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.90274998 |
| 46 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.89712447 |
| 47 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.89524595 |
| 48 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.88402788 |
| 49 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.85917201 |
| 50 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.84623716 |
| 51 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.83758012 |
| 52 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.83736839 |
| 53 | Peroxisome_Homo sapiens_hsa04146 | 0.80618135 |
| 54 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.80445384 |
| 55 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.79895707 |
| 56 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.75446611 |
| 57 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.75131342 |
| 58 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.74418570 |
| 59 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.73466938 |
| 60 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.71604469 |
| 61 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.70757008 |
| 62 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.70301281 |
| 63 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.67574108 |
| 64 | Asthma_Homo sapiens_hsa05310 | 0.66301862 |
| 65 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.66269325 |
| 66 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.65093888 |
| 67 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.65038150 |
| 68 | Shigellosis_Homo sapiens_hsa05131 | 0.64363896 |
| 69 | Other glycan degradation_Homo sapiens_hsa00511 | 0.62075053 |
| 70 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.61676500 |
| 71 | Retinol metabolism_Homo sapiens_hsa00830 | 0.61106819 |
| 72 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.60231814 |
| 73 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.60099954 |
| 74 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.58924658 |
| 75 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.58838470 |
| 76 | Metabolic pathways_Homo sapiens_hsa01100 | 0.58540329 |
| 77 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.58286823 |
| 78 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.56955936 |
| 79 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.56196383 |
| 80 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.56057585 |
| 81 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.55548176 |
| 82 | Sulfur relay system_Homo sapiens_hsa04122 | 0.54985719 |
| 83 | Legionellosis_Homo sapiens_hsa05134 | 0.53554334 |
| 84 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.53501738 |
| 85 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.53018773 |
| 86 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.52202462 |
| 87 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.51580844 |
| 88 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.51136993 |
| 89 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.50773701 |
| 90 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.50582452 |
| 91 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.50227736 |
| 92 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.50073285 |
| 93 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.49942406 |
| 94 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.49581194 |
| 95 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.49449055 |
| 96 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.48605568 |
| 97 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.48474898 |
| 98 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.47413758 |
| 99 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.47083277 |
| 100 | Phagosome_Homo sapiens_hsa04145 | 0.45978580 |
| 101 | Measles_Homo sapiens_hsa05162 | 0.44730097 |
| 102 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.44445256 |
| 103 | Galactose metabolism_Homo sapiens_hsa00052 | 0.44333180 |
| 104 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.43591651 |
| 105 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.43558959 |
| 106 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.43308981 |
| 107 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.43298910 |
| 108 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.43195309 |
| 109 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.42424823 |
| 110 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.41070709 |
| 111 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.40753230 |
| 112 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.40576576 |
| 113 | Pertussis_Homo sapiens_hsa05133 | 0.40221935 |
| 114 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.39337682 |
| 115 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.38207117 |
| 116 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.35595000 |
| 117 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.34770126 |
| 118 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.30863722 |
| 119 | Apoptosis_Homo sapiens_hsa04210 | 0.30552833 |
| 120 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.30094346 |
| 121 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.30012069 |
| 122 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.27753249 |
| 123 | Leishmaniasis_Homo sapiens_hsa05140 | 0.27467650 |
| 124 | Lysosome_Homo sapiens_hsa04142 | 0.25922831 |
| 125 | Nicotine addiction_Homo sapiens_hsa05033 | 0.25498532 |
| 126 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.24545892 |
| 127 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.22825452 |
| 128 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.22632372 |
| 129 | Alcoholism_Homo sapiens_hsa05034 | 0.21967068 |
| 130 | Salmonella infection_Homo sapiens_hsa05132 | 0.21963322 |
| 131 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.20466635 |
| 132 | Phototransduction_Homo sapiens_hsa04744 | 0.20431748 |
| 133 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.19466785 |
| 134 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.18770841 |
| 135 | Malaria_Homo sapiens_hsa05144 | 0.17148672 |
| 136 | Tuberculosis_Homo sapiens_hsa05152 | 0.16099825 |
| 137 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.16079454 |
| 138 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.15789842 |
| 139 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.12877985 |
| 140 | Influenza A_Homo sapiens_hsa05164 | 0.11230205 |
| 141 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.11165390 |

