COMMD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.30550800
2DNA deamination (GO:0045006)5.28617603
3establishment of protein localization to mitochondrial membrane (GO:0090151)5.18198170
4ribosomal small subunit biogenesis (GO:0042274)5.05879258
5proteasome assembly (GO:0043248)4.83450950
6viral transcription (GO:0019083)4.81439278
7translational termination (GO:0006415)4.63787562
8L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.45233402
9water-soluble vitamin biosynthetic process (GO:0042364)4.41224136
10termination of RNA polymerase III transcription (GO:0006386)4.37394150
11transcription elongation from RNA polymerase III promoter (GO:0006385)4.37394150
12maturation of SSU-rRNA (GO:0030490)4.36762764
13behavioral response to nicotine (GO:0035095)4.30963221
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.23488760
15negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.22450330
16ribosomal large subunit biogenesis (GO:0042273)4.22144662
17cotranslational protein targeting to membrane (GO:0006613)4.21851330
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.20039107
19protein targeting to ER (GO:0045047)4.13231933
20translational elongation (GO:0006414)4.02327033
21DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.97246581
22protein localization to endoplasmic reticulum (GO:0070972)3.96884201
23protein complex biogenesis (GO:0070271)3.95220597
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.95005842
25mitochondrial respiratory chain complex I assembly (GO:0032981)3.95005842
26NADH dehydrogenase complex assembly (GO:0010257)3.95005842
27cullin deneddylation (GO:0010388)3.91078693
28establishment of protein localization to endoplasmic reticulum (GO:0072599)3.90503231
29formation of translation preinitiation complex (GO:0001731)3.90432259
30energy coupled proton transport, down electrochemical gradient (GO:0015985)3.89994154
31ATP synthesis coupled proton transport (GO:0015986)3.89994154
32intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.89097976
33signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.89097976
34negative regulation of ligase activity (GO:0051352)3.88523307
35negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.88523307
36antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.86661742
37signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.86192783
38signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.86192783
39signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.86192783
40positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.82301750
41viral life cycle (GO:0019058)3.76941838
42regulation of cellular amino acid metabolic process (GO:0006521)3.76612250
43telomere maintenance via semi-conservative replication (GO:0032201)3.75950433
44respiratory chain complex IV assembly (GO:0008535)3.75432861
45signal transduction involved in DNA damage checkpoint (GO:0072422)3.71619828
46signal transduction involved in DNA integrity checkpoint (GO:0072401)3.71619828
47cellular protein complex disassembly (GO:0043624)3.71344243
48DNA replication checkpoint (GO:0000076)3.71311480
49deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.70819510
50protein neddylation (GO:0045116)3.69617837
51translational initiation (GO:0006413)3.69271707
52regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.68843146
53antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.68233533
54chaperone-mediated protein transport (GO:0072321)3.67850674
557-methylguanosine mRNA capping (GO:0006370)3.67718892
567-methylguanosine RNA capping (GO:0009452)3.67006020
57RNA capping (GO:0036260)3.67006020
58mitochondrial respiratory chain complex assembly (GO:0033108)3.66673483
59signal transduction involved in cell cycle checkpoint (GO:0072395)3.66542028
60translation (GO:0006412)3.66215224
61protein deneddylation (GO:0000338)3.64191761
62pseudouridine synthesis (GO:0001522)3.64168652
63pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.54710126
64RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.52895699
65tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.52895699
66DNA strand elongation involved in DNA replication (GO:0006271)3.52367056
67ribonucleoprotein complex biogenesis (GO:0022613)3.51686542
68peptidyl-histidine modification (GO:0018202)3.49975869
69anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.49794747
70mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.46053953
71UTP biosynthetic process (GO:0006228)3.45629501
72regulation of mitochondrial translation (GO:0070129)3.45183165
73nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.42588361
74cellular component biogenesis (GO:0044085)3.39591330
75DNA strand elongation (GO:0022616)3.37150863
76cytochrome complex assembly (GO:0017004)3.36060802
77L-methionine salvage (GO:0071267)3.36059566
78L-methionine biosynthetic process (GO:0071265)3.36059566
79amino acid salvage (GO:0043102)3.36059566
80protein targeting to mitochondrion (GO:0006626)3.36053527
81chromatin remodeling at centromere (GO:0031055)3.32820609
82metallo-sulfur cluster assembly (GO:0031163)3.32806511
83iron-sulfur cluster assembly (GO:0016226)3.32806511
84telomere maintenance via recombination (GO:0000722)3.28175815
85establishment of protein localization to mitochondrion (GO:0072655)3.25132137
86positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.21760072
87transcription-coupled nucleotide-excision repair (GO:0006283)3.21033892
88rRNA processing (GO:0006364)3.20950092
89respiratory electron transport chain (GO:0022904)3.17868225
90nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.16785779
91DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.16197097
92rRNA modification (GO:0000154)3.14645119
93pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.14307381
94positive regulation of ligase activity (GO:0051351)3.13633825
95viral mRNA export from host cell nucleus (GO:0046784)3.12784051
96CENP-A containing nucleosome assembly (GO:0034080)3.12458966
97replication fork processing (GO:0031297)3.11222633
98protein complex disassembly (GO:0043241)3.10271293
99electron transport chain (GO:0022900)3.09576912
100establishment of integrated proviral latency (GO:0075713)3.07928898
101transcription from RNA polymerase I promoter (GO:0006360)3.07172677
102exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.06509603
103termination of RNA polymerase I transcription (GO:0006363)3.05209452
104UTP metabolic process (GO:0046051)3.04642312
105rRNA metabolic process (GO:0016072)3.03848525
106macromolecular complex disassembly (GO:0032984)3.02955637
107transcription elongation from RNA polymerase I promoter (GO:0006362)3.02521482
108positive regulation of cell cycle arrest (GO:0071158)3.02272184
109protein localization to mitochondrion (GO:0070585)3.02143560
110protein-cofactor linkage (GO:0018065)3.02104177
111base-excision repair, AP site formation (GO:0006285)3.01851222
112pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.01336794
113oxidative phosphorylation (GO:0006119)3.01228675
114tRNA processing (GO:0008033)3.00446064
115GTP biosynthetic process (GO:0006183)2.98233977
116CTP biosynthetic process (GO:0006241)2.94696047
117CTP metabolic process (GO:0046036)2.94696047
118antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.93438313
119maturation of 5.8S rRNA (GO:0000460)2.92259203
120purine nucleoside triphosphate biosynthetic process (GO:0009145)2.91921965
121establishment of viral latency (GO:0019043)2.91408831
122purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.90992302
123nucleotide-excision repair, DNA gap filling (GO:0006297)2.90309410
124kynurenine metabolic process (GO:0070189)2.89620097
125guanosine-containing compound biosynthetic process (GO:1901070)2.87231395
126tRNA modification (GO:0006400)2.87125552
127intracellular protein transmembrane import (GO:0044743)2.84744583
128pyrimidine nucleotide catabolic process (GO:0006244)2.83601695
129pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.83276711
130mitochondrial RNA metabolic process (GO:0000959)2.83091769
131inner mitochondrial membrane organization (GO:0007007)2.82225631
132pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.74474102
133mannosylation (GO:0097502)2.73414964
134protein K6-linked ubiquitination (GO:0085020)2.73003868
135ribonucleoside triphosphate biosynthetic process (GO:0009201)2.72224292
136negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.71779453
137spliceosomal snRNP assembly (GO:0000387)2.70500630
138RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.68303497
139kinetochore assembly (GO:0051382)2.68209180
140ncRNA processing (GO:0034470)2.67350976
141ATP biosynthetic process (GO:0006754)2.66988936
142DNA damage response, detection of DNA damage (GO:0042769)2.66877317
143nuclear-transcribed mRNA catabolic process (GO:0000956)2.64572057

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.61348984
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.27363464
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.25268692
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.22371632
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.09982039
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.09164332
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.84347318
8E2F7_22180533_ChIP-Seq_HELA_Human3.65301941
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.59164677
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.37199794
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.28275758
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.24426102
13ELF1_17652178_ChIP-ChIP_JURKAT_Human3.20821598
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.07170295
15MYC_18358816_ChIP-ChIP_MESCs_Mouse3.00706195
16* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.99950031
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.96034841
18VDR_23849224_ChIP-Seq_CD4+_Human2.73268964
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.72113900
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.60877038
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.60149440
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.59035987
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.58251892
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.49346618
25DCP1A_22483619_ChIP-Seq_HELA_Human2.39237023
26YY1_21170310_ChIP-Seq_MESCs_Mouse2.37433917
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.35892387
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.30988617
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.27592014
30FOXP3_21729870_ChIP-Seq_TREG_Human2.27340997
31XRN2_22483619_ChIP-Seq_HELA_Human2.27108369
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.24387434
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.14347015
34ELK1_19687146_ChIP-ChIP_HELA_Human2.10061327
35* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.01027810
36E2F4_17652178_ChIP-ChIP_JURKAT_Human2.00969455
37GABP_19822575_ChIP-Seq_HepG2_Human2.00719005
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.98242755
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.96528719
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.93940154
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89736621
42TTF2_22483619_ChIP-Seq_HELA_Human1.87619705
43* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.86422243
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76852575
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.73262612
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.72596096
47ZNF274_21170338_ChIP-Seq_K562_Hela1.69357920
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.67218024
49IRF8_21731497_ChIP-ChIP_J774_Mouse1.65471729
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.61485753
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60066473
52* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.59533290
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56556565
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56261286
55* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.54998043
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.51710501
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.49353532
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48860782
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42214380
60IRF8_22096565_ChIP-ChIP_GC-B_Human1.37247763
61SPI1_23547873_ChIP-Seq_NB4_Human1.37225402
62* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.36569279
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36370309
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32164247
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.31320267
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.28305814
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.23204407
68FOXP1_21924763_ChIP-Seq_HESCs_Human1.20067306
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18900812
70CIITA_25753668_ChIP-Seq_RAJI_Human1.18553328
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17704653
72STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16110045
73* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14763237
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14228734
75IRF1_19129219_ChIP-ChIP_H3396_Human1.13569212
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12225735
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11876988
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.11373384
79GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10224315
80CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08491053
81ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07389775
82SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07340191
83KDM5A_27292631_Chip-Seq_BREAST_Human1.07024585
84ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05401450
85SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04370616
86TET1_21451524_ChIP-Seq_MESCs_Mouse1.03737661
87* TFEB_21752829_ChIP-Seq_HELA_Human1.03709330
88RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.02820748
89MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02345322
90RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02219014
91MYC_18940864_ChIP-ChIP_HL60_Human1.02190067
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99874616
93ERA_21632823_ChIP-Seq_H3396_Human0.99642408
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98840288
95CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98465025
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97474732
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97449961
98* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97212083
99PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96410050
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92269656
101VDR_22108803_ChIP-Seq_LS180_Human0.92182630
102SOX2_16153702_ChIP-ChIP_HESCs_Human0.91605885
103EWS_26573619_Chip-Seq_HEK293_Human0.91210419
104MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.89780070
105EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89377104
106CTCF_20526341_ChIP-Seq_ESCs_Human0.88334789
107PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87919018
108BCL6_27268052_Chip-Seq_Bcells_Human0.87644297
109PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.86844799
110* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85892127
111TP53_22573176_ChIP-Seq_HFKS_Human0.85386564
112TAF2_19829295_ChIP-Seq_ESCs_Human0.84087135
113CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83598658
114PHF8_20622854_ChIP-Seq_HELA_Human0.83324025
115ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.83117061
116* E2F1_20622854_ChIP-Seq_HELA_Human0.82922911
117BP1_19119308_ChIP-ChIP_Hs578T_Human0.82887661
118SOX17_20123909_ChIP-Seq_XEN_Mouse0.80670023
119PU.1_20513432_ChIP-Seq_Bcells_Mouse0.79330813
120LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.78051871
121E2F1_21310950_ChIP-Seq_MCF-7_Human0.77253862
122YY1_22570637_ChIP-Seq_MALME-3M_Human0.77021757
123NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.75731014
124* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.73007973
125SOX2_18555785_ChIP-Seq_MESCs_Mouse0.72609338
126POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.71456615
127* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.71066304
128HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.67327519
129CTCF_26484167_Chip-Seq_Bcells_Mouse0.67015672

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.01086340
2MP0009379_abnormal_foot_pigmentation2.98724287
3MP0008058_abnormal_DNA_repair2.87370990
4MP0005671_abnormal_response_to2.85010628
5MP0001835_abnormal_antigen_presentation2.84646441
6MP0002837_dystrophic_cardiac_calcinosis2.83087215
7MP0004957_abnormal_blastocyst_morpholog2.71573017
8MP0003646_muscle_fatigue2.60689391
9MP0010094_abnormal_chromosome_stability2.58954159
10MP0002148_abnormal_hypersensitivity_rea2.42758060
11MP0009785_altered_susceptibility_to2.41552227
12MP0010030_abnormal_orbit_morphology2.36877845
13MP0003077_abnormal_cell_cycle2.28010485
14MP0005646_abnormal_pituitary_gland2.18853108
15MP0008057_abnormal_DNA_replication2.11124490
16MP0003186_abnormal_redox_activity2.10464268
17MP0009333_abnormal_splenocyte_physiolog2.09102528
18MP0001986_abnormal_taste_sensitivity2.08546547
19MP0003806_abnormal_nucleotide_metabolis2.06874880
20MP0003111_abnormal_nucleus_morphology2.04111951
21MP0002160_abnormal_reproductive_system2.02407074
22MP0005075_abnormal_melanosome_morpholog2.01583982
23MP0006292_abnormal_olfactory_placode2.01532793
24MP0008007_abnormal_cellular_replicative1.99816452
25MP0001529_abnormal_vocalization1.96494039
26MP0003195_calcinosis1.94082836
27MP0000685_abnormal_immune_system1.93939283
28MP0003763_abnormal_thymus_physiology1.91378230
29MP0005025_abnormal_response_to1.88380198
30MP0001800_abnormal_humoral_immune1.85347346
31MP0000049_abnormal_middle_ear1.84563459
32MP0005000_abnormal_immune_tolerance1.84067765
33MP0003786_premature_aging1.83674081
34MP0008932_abnormal_embryonic_tissue1.79349744
35MP0002420_abnormal_adaptive_immunity1.79094976
36MP0002132_abnormal_respiratory_system1.78399173
37MP0002723_abnormal_immune_serum1.77748915
38MP0001819_abnormal_immune_cell1.77544590
39MP0003880_abnormal_central_pattern1.76240960
40MP0002452_abnormal_antigen_presenting1.73475789
41MP0002102_abnormal_ear_morphology1.71419690
42MP0001905_abnormal_dopamine_level1.71399779
43MP0006072_abnormal_retinal_apoptosis1.70112222
44MP0002396_abnormal_hematopoietic_system1.67752099
45MP0008789_abnormal_olfactory_epithelium1.67021331
46MP0002653_abnormal_ependyma_morphology1.65624976
47MP0002398_abnormal_bone_marrow1.65045296
48MP0001853_heart_inflammation1.62185606
49MP0005389_reproductive_system_phenotype1.59141022
50MP0001188_hyperpigmentation1.58464908
51MP0005551_abnormal_eye_electrophysiolog1.56327414
52MP0000631_abnormal_neuroendocrine_gland1.55637628
53MP0005387_immune_system_phenotype1.55359952
54MP0001790_abnormal_immune_system1.55359952
55MP0000716_abnormal_immune_system1.54484375
56MP0008260_abnormal_autophagy1.53602549
57MP0009053_abnormal_anal_canal1.51540731
58MP0006036_abnormal_mitochondrial_physio1.49604654
59MP0003718_maternal_effect1.48784863
60MP0000689_abnormal_spleen_morphology1.45329704
61MP0004142_abnormal_muscle_tone1.45108273
62MP0002419_abnormal_innate_immunity1.41972844
63MP0001348_abnormal_lacrimal_gland1.41414833
64MP0002429_abnormal_blood_cell1.40985135
65MP0008872_abnormal_physiological_respon1.40936945
66MP0005670_abnormal_white_adipose1.40311702
67MP0005379_endocrine/exocrine_gland_phen1.38540664
68MP0002722_abnormal_immune_system1.35235592
69MP0000490_abnormal_crypts_of1.32885137
70MP0001293_anophthalmia1.31275169
71MP0008875_abnormal_xenobiotic_pharmacok1.31266052
72MP0003724_increased_susceptibility_to1.30795028
73MP0004147_increased_porphyrin_level1.28465693
74MP0006082_CNS_inflammation1.28034792
75MP0002736_abnormal_nociception_after1.24274788
76MP0002405_respiratory_system_inflammati1.23969789
77MP0002638_abnormal_pupillary_reflex1.20224767
78MP0003937_abnormal_limbs/digits/tail_de1.19698252
79MP0000313_abnormal_cell_death1.18674593
80MP0001919_abnormal_reproductive_system1.17717783
81MP0005174_abnormal_tail_pigmentation1.15804404
82MP0005332_abnormal_amino_acid1.14376756
83MP0004381_abnormal_hair_follicle1.13503699
84MP0000372_irregular_coat_pigmentation1.11679236
85MP0000537_abnormal_urethra_morphology1.10678524
86MP0003283_abnormal_digestive_organ1.10240739
87MP0002210_abnormal_sex_determination1.09618482
88MP0000465_gastrointestinal_hemorrhage1.09473921
89MP0000920_abnormal_myelination1.08653913
90MP0005253_abnormal_eye_physiology1.07872708
91MP0008995_early_reproductive_senescence1.07813524
92MP0006035_abnormal_mitochondrial_morpho1.06042497
93MP0003011_delayed_dark_adaptation1.05402502
94MP0009046_muscle_twitch1.05076946
95MP0000703_abnormal_thymus_morphology1.03771473
96MP0000015_abnormal_ear_pigmentation1.03621162
97MP0003436_decreased_susceptibility_to1.03082872
98MP0009250_abnormal_appendicular_skeleto1.02962683
99MP0005084_abnormal_gallbladder_morpholo1.02889660
100MP0009840_abnormal_foam_cell1.01549188
101MP0002234_abnormal_pharynx_morphology1.01406663
102MP0005360_urolithiasis1.00826402
103MP0002277_abnormal_respiratory_mucosa1.00749261
104MP0008877_abnormal_DNA_methylation0.99494697
105MP0002019_abnormal_tumor_incidence0.98800548
106MP0004133_heterotaxia0.98403577
107MP0002095_abnormal_skin_pigmentation0.98108361
108MP0000026_abnormal_inner_ear0.97488330
109MP0003938_abnormal_ear_development0.97012243
110MP0005171_absent_coat_pigmentation0.96047698
111MP0005195_abnormal_posterior_eye0.95847594
112MP0001145_abnormal_male_reproductive0.94650925
113MP0004145_abnormal_muscle_electrophysio0.94208513
114MP0003119_abnormal_digestive_system0.93039179
115MP0000538_abnormal_urinary_bladder0.91909685
116MP0005397_hematopoietic_system_phenotyp0.91479438
117MP0001545_abnormal_hematopoietic_system0.91479438
118MP0002249_abnormal_larynx_morphology0.90364726
119MP0008004_abnormal_stomach_pH0.88840468
120MP0003136_yellow_coat_color0.88436200
121MP0005377_hearing/vestibular/ear_phenot0.87715572
122MP0003878_abnormal_ear_physiology0.87715572
123MP0001845_abnormal_inflammatory_respons0.87045928
124MP0001968_abnormal_touch/_nociception0.86519007
125MP0001324_abnormal_eye_pigmentation0.86254859
126MP0005408_hypopigmentation0.85280440
127MP0000681_abnormal_thyroid_gland0.85031046
128MP0000653_abnormal_sex_gland0.84947572
129MP0003315_abnormal_perineum_morphology0.84947309
130MP0002876_abnormal_thyroid_physiology0.84133636
131MP0005499_abnormal_olfactory_system0.83990605
132MP0005394_taste/olfaction_phenotype0.83990605
133MP0003567_abnormal_fetal_cardiomyocyte0.83391786
134MP0003942_abnormal_urinary_system0.83313900
135MP0001764_abnormal_homeostasis0.82615607
136MP0002751_abnormal_autonomic_nervous0.82562674
137MP0003866_abnormal_defecation0.82546975
138MP0002163_abnormal_gland_morphology0.81549462
139MP0005310_abnormal_salivary_gland0.81248539
140MP0002735_abnormal_chemical_nociception0.80786609
141MP0008469_abnormal_protein_level0.79286599
142MP0001963_abnormal_hearing_physiology0.78720155
143MP0001485_abnormal_pinna_reflex0.78081814
144MP0004742_abnormal_vestibular_system0.76688012
145MP0000858_altered_metastatic_potential0.76318650
146MP0010155_abnormal_intestine_physiology0.75543666
147MP0001929_abnormal_gametogenesis0.75481242
148MP0005410_abnormal_fertilization0.74527726
149MP0005409_darkened_coat_color0.74338989
150MP0003950_abnormal_plasma_membrane0.74035706
151MP0000358_abnormal_cell_content/0.72350098
152MP0002938_white_spotting0.72330151
153MP0002272_abnormal_nervous_system0.71734417
154MP0005391_vision/eye_phenotype0.70902072
155MP0009697_abnormal_copulation0.70068814
156MP0009745_abnormal_behavioral_response0.69889752
157MP0001119_abnormal_female_reproductive0.68971583
158MP0002752_abnormal_somatic_nervous0.68848034
159MP0002557_abnormal_social/conspecific_i0.64880857

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.61302523
2Mitochondrial inheritance (HP:0001427)4.60486099
3Hepatocellular necrosis (HP:0001404)4.53554008
4Abnormal mitochondria in muscle tissue (HP:0008316)4.27270584
53-Methylglutaconic aciduria (HP:0003535)4.20558990
6Abnormality of cells of the erythroid lineage (HP:0012130)4.19493007
7Abnormal number of erythroid precursors (HP:0012131)4.05374115
8Increased CSF lactate (HP:0002490)4.01762640
9Reticulocytopenia (HP:0001896)3.95030462
10Hepatic necrosis (HP:0002605)3.91638096
11Increased hepatocellular lipid droplets (HP:0006565)3.90266135
12Acute encephalopathy (HP:0006846)3.68312732
13Cerebral hypomyelination (HP:0006808)3.60487417
14Progressive macrocephaly (HP:0004481)3.59221891
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.57712235
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.55897075
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.55897075
18Type I transferrin isoform profile (HP:0003642)3.50295244
19Renal Fanconi syndrome (HP:0001994)3.46090428
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.37667108
21Aplasia/Hypoplasia of the sacrum (HP:0008517)3.36424524
22Increased serum lactate (HP:0002151)3.33130690
23Lipid accumulation in hepatocytes (HP:0006561)3.32242037
24Increased serum pyruvate (HP:0003542)3.25594998
25Abnormality of glycolysis (HP:0004366)3.25594998
26Exertional dyspnea (HP:0002875)3.18539850
27Macrocytic anemia (HP:0001972)3.12193484
28Methylmalonic aciduria (HP:0012120)3.08551297
29Pendular nystagmus (HP:0012043)3.05959282
30Birth length less than 3rd percentile (HP:0003561)2.97862175
31Absent thumb (HP:0009777)2.93993076
32Pancreatic fibrosis (HP:0100732)2.91881034
33Increased intramyocellular lipid droplets (HP:0012240)2.91705952
34Pallor (HP:0000980)2.81989780
35Lactic acidosis (HP:0003128)2.73352867
36Microvesicular hepatic steatosis (HP:0001414)2.72961154
37Aplastic anemia (HP:0001915)2.72784451
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.71543049
39Respiratory failure (HP:0002878)2.70044693
40Congenital, generalized hypertrichosis (HP:0004540)2.65428048
41Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.63282328
42Abnormal protein N-linked glycosylation (HP:0012347)2.63282328
43Abnormal protein glycosylation (HP:0012346)2.63282328
44Abnormal glycosylation (HP:0012345)2.63282328
45Methylmalonic acidemia (HP:0002912)2.62202596
46Exercise intolerance (HP:0003546)2.61171718
47True hermaphroditism (HP:0010459)2.59953869
48Congenital stationary night blindness (HP:0007642)2.58740091
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.53801719
50Leukodystrophy (HP:0002415)2.51580854
51Abnormality of midbrain morphology (HP:0002418)2.51214506
52Molar tooth sign on MRI (HP:0002419)2.51214506
53Chromsome breakage (HP:0040012)2.45883343
54Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.43378908
55Respiratory difficulties (HP:0002880)2.42275637
56Reduced antithrombin III activity (HP:0001976)2.42005153
57IgG deficiency (HP:0004315)2.34638583
58Hyperglycinemia (HP:0002154)2.33395003
59B lymphocytopenia (HP:0010976)2.32383290
60Abnormality of B cell number (HP:0010975)2.32383290
61Aplasia/Hypoplasia of the patella (HP:0006498)2.31466777
62IgM deficiency (HP:0002850)2.31012683
63Sclerocornea (HP:0000647)2.30925341
64Increased muscle lipid content (HP:0009058)2.29528383
65Abnormality of renal resorption (HP:0011038)2.29374836
66Breast hypoplasia (HP:0003187)2.27284738
67Elevated erythrocyte sedimentation rate (HP:0003565)2.26894430
68Optic disc pallor (HP:0000543)2.26591304
69Parakeratosis (HP:0001036)2.24229593
70Concave nail (HP:0001598)2.21111385
71Hepatosplenomegaly (HP:0001433)2.20908651
72Poor head control (HP:0002421)2.20013281
73Nephronophthisis (HP:0000090)2.19049298
74Cleft eyelid (HP:0000625)2.17034639
75Patellar aplasia (HP:0006443)2.16521638
76Absent rod-and cone-mediated responses on ERG (HP:0007688)2.15244845
77Recurrent abscess formation (HP:0002722)2.15189331
78Abnormal hair whorl (HP:0010721)2.14256746
79Triphalangeal thumb (HP:0001199)2.13724599
80Cerebral edema (HP:0002181)2.13065228
81Decreased electroretinogram (ERG) amplitude (HP:0000654)2.12178555
82Abnormal number of incisors (HP:0011064)2.11441286
83Abnormality of DNA repair (HP:0003254)2.11322468
84Premature graying of hair (HP:0002216)2.10952001
85Pancytopenia (HP:0001876)2.10777364
86Type 2 muscle fiber atrophy (HP:0003554)2.08733514
87Agnosia (HP:0010524)2.08536701
88Rough bone trabeculation (HP:0100670)2.08392507
89Emotional lability (HP:0000712)2.08386563
90Abnormality of alanine metabolism (HP:0010916)2.07522505
91Hyperalaninemia (HP:0003348)2.07522505
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07522505
93CNS demyelination (HP:0007305)2.06861291
94Muscle fiber atrophy (HP:0100295)2.04568395
95Lethargy (HP:0001254)2.04098827
96Dicarboxylic aciduria (HP:0003215)2.03402375
97Abnormality of dicarboxylic acid metabolism (HP:0010995)2.03402375
98Asplenia (HP:0001746)2.01663183
99Hypoplasia of the pons (HP:0012110)2.01141914
100Cutaneous melanoma (HP:0012056)2.00780706
101Type II lissencephaly (HP:0007260)1.99463587
102Opisthotonus (HP:0002179)1.98419353
103Ectopic kidney (HP:0000086)1.97666002
104Severe combined immunodeficiency (HP:0004430)1.97438804
105Oral leukoplakia (HP:0002745)1.95677702
106Short thumb (HP:0009778)1.95489394
107Abolished electroretinogram (ERG) (HP:0000550)1.94730273
108Anencephaly (HP:0002323)1.94100850
109Duplicated collecting system (HP:0000081)1.93580595
110Abnormal rod and cone electroretinograms (HP:0008323)1.91917668
111Vacuolated lymphocytes (HP:0001922)1.91299263
112Lymphoma (HP:0002665)1.89054984
113Petechiae (HP:0000967)1.88285773
114Congenital ichthyosiform erythroderma (HP:0007431)1.88148021
115Bone marrow hypocellularity (HP:0005528)1.87772934
116Abnormal trabecular bone morphology (HP:0100671)1.87762616
117Horseshoe kidney (HP:0000085)1.86829163
118Abnormality of macrophages (HP:0004311)1.85835027
119Abnormality of cochlea (HP:0000375)1.85823640
120Abnormality of the pons (HP:0007361)1.85767261
121Increased IgM level (HP:0003496)1.85400549
122Colon cancer (HP:0003003)1.83833038
123Granulocytopenia (HP:0001913)1.82659035
124Cystic liver disease (HP:0006706)1.82394718
125Neutropenia (HP:0001875)1.82050780
126Septo-optic dysplasia (HP:0100842)1.81656951
127Abnormality of the preputium (HP:0100587)1.81492512
128Abnormality of serum amino acid levels (HP:0003112)1.80574767
129CNS hypomyelination (HP:0003429)1.80059553
130Thrombocytosis (HP:0001894)1.78529277
131Abnormality of the heme biosynthetic pathway (HP:0010472)1.78274797
132Aplasia/Hypoplasia of the spleen (HP:0010451)1.77368370
133Abnormality of the carotid arteries (HP:0005344)1.73997060
134Postnatal microcephaly (HP:0005484)1.72908158
135Hypoplasia of the radius (HP:0002984)1.72851606
136Abnormality of the renal collecting system (HP:0004742)1.71844349
137Aplasia/hypoplasia of the uterus (HP:0008684)1.71445157
138Severe visual impairment (HP:0001141)1.70504472
139Abnormality of chromosome stability (HP:0003220)1.69045433
140Abnormality of the ileum (HP:0001549)1.68940048
141Pancreatic cysts (HP:0001737)1.68741798
142Combined immunodeficiency (HP:0005387)1.67669470
143Medial flaring of the eyebrow (HP:0010747)1.66740048
144Microretrognathia (HP:0000308)1.65583837
145Meckel diverticulum (HP:0002245)1.65160259
146Pulmonary fibrosis (HP:0002206)1.63088646

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.67501949
2STK163.92227269
3FRK3.50162494
4NME23.36148793
5BUB13.24616985
6EIF2AK13.09568260
7MAP3K122.59081953
8PIM22.48919845
9VRK12.39974244
10TESK22.20018272
11MST42.19641892
12WEE12.12658667
13ARAF1.93495574
14CCNB11.93199840
15PBK1.88625499
16EIF2AK31.88018351
17MAP4K11.86759306
18SRPK11.83563157
19CDK191.78226489
20MAP4K21.71347085
21TLK11.68967775
22TXK1.66849767
23NUAK11.57465028
24TNIK1.56399331
25NME11.52411785
26NEK11.46910335
27TSSK61.44535835
28ADRBK21.42356429
29BRAF1.37425444
30CHEK21.36479076
31IRAK41.35024513
32WNK31.30927537
33CASK1.30471914
34MAP3K111.25712306
35KDR1.24335714
36PLK41.21130281
37WNK41.21116855
38SIK31.20715718
39INSRR1.19973729
40MKNK11.18156005
41BLK1.17414672
42BCR1.15838088
43PDK21.13404088
44MAP2K71.12177255
45NEK21.10289929
46TEC1.08900698
47OXSR11.06836110
48STK391.06457867
49PRPF4B1.05148957
50TAF11.04248852
51MAPKAPK31.04153004
52MUSK1.03089892
53BMPR1B1.01537834
54EIF2AK21.01075760
55MAP3K140.99317380
56AKT30.99108035
57GRK70.98761219
58KIT0.98617786
59TTK0.97199600
60YES10.96794912
61IKBKB0.96084898
62BRSK20.96069150
63SYK0.95578656
64CSNK1G30.92214732
65CDC70.91597154
66ACVR1B0.91366788
67TYK20.89277781
68DAPK10.89102402
69PRKCI0.87266574
70DYRK20.85716134
71CLK10.82467048
72EPHB20.76682053
73LYN0.76462578
74PLK10.75995874
75AURKA0.75993655
76CDK80.75464100
77ADRBK10.75226870
78CSNK1G20.73972164
79LIMK10.72525056
80TBK10.71228697
81TGFBR10.71038688
82BTK0.69475910
83BMPR20.69263970
84PINK10.68472138
85PRKCG0.65369439
86TAOK20.64738522
87ATR0.63139360
88MYLK0.62625867
89CSNK1G10.61613449
90DAPK30.60893378
91MKNK20.60302489
92ABL20.59912076
93MAPK150.59800487
94SCYL20.58893221
95RIPK40.58570474
96LCK0.57730352
97CSNK2A10.56951465
98IRAK30.56224824
99ZAP700.55549910
100MAP2K60.55350892
101MAPK130.54143331
102MAP2K20.54084191
103AURKB0.53871254
104CSNK2A20.52871298
105IKBKE0.50912927
106STK40.50840678
107CDK70.50323351
108ILK0.50228460
109RPS6KB20.49553692
110PASK0.49442235
111TESK10.49411402
112CSNK1A10.49055031
113BRSK10.48918651
114RPS6KA50.48768503
115PRKCD0.45486713
116CHEK10.45049675
117CSNK1A1L0.44580367
118GRK10.43477806
119PRKD20.41784214
120DYRK30.41476915
121PAK10.40996269
122PLK30.38989078
123PIM10.38962491
124GRK60.38021700
125CSF1R0.37986535
126MAPKAPK50.37562742
127TIE10.37064295
128ATM0.36836474
129MATK0.36115660
130ZAK0.35629459
131BCKDK0.34543447
132CDK11A0.34174029
133RPS6KA60.34127386
134FLT30.31155599
135CDK40.27001659
136PKN10.26765833
137CDK10.26561551
138CDK20.26163754
139PRKACA0.25443562

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.82659918
2Proteasome_Homo sapiens_hsa030504.75106275
3RNA polymerase_Homo sapiens_hsa030203.84213313
4DNA replication_Homo sapiens_hsa030303.67423669
5Oxidative phosphorylation_Homo sapiens_hsa001903.26153254
6Mismatch repair_Homo sapiens_hsa034302.96531554
7Parkinsons disease_Homo sapiens_hsa050122.76162583
8Homologous recombination_Homo sapiens_hsa034402.51702791
9Pyrimidine metabolism_Homo sapiens_hsa002402.43284160
10Base excision repair_Homo sapiens_hsa034102.37655923
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.36960102
12Spliceosome_Homo sapiens_hsa030402.33940022
13Protein export_Homo sapiens_hsa030602.28929635
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.18285643
15Nucleotide excision repair_Homo sapiens_hsa034202.11196621
16Huntingtons disease_Homo sapiens_hsa050162.00330239
17Alzheimers disease_Homo sapiens_hsa050101.95962543
18Non-homologous end-joining_Homo sapiens_hsa034501.83138450
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62079779
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60626581
21Primary immunodeficiency_Homo sapiens_hsa053401.60197159
22Sulfur metabolism_Homo sapiens_hsa009201.48508334
23Basal transcription factors_Homo sapiens_hsa030221.45680221
24Fanconi anemia pathway_Homo sapiens_hsa034601.45502452
25Purine metabolism_Homo sapiens_hsa002301.44780923
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44473218
27Selenocompound metabolism_Homo sapiens_hsa004501.44124543
28RNA transport_Homo sapiens_hsa030131.42270690
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37801319
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.29083358
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23339185
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.19543078
33Tryptophan metabolism_Homo sapiens_hsa003801.17562156
34RNA degradation_Homo sapiens_hsa030181.16510134
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13650150
36Allograft rejection_Homo sapiens_hsa053301.12231777
37Folate biosynthesis_Homo sapiens_hsa007901.06195598
38Collecting duct acid secretion_Homo sapiens_hsa049661.03252796
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02991014
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99464318
41Epstein-Barr virus infection_Homo sapiens_hsa051690.96292121
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94448567
43Cell cycle_Homo sapiens_hsa041100.93974628
44Maturity onset diabetes of the young_Homo sapiens_hsa049500.90970541
45Graft-versus-host disease_Homo sapiens_hsa053320.90274998
46Arachidonic acid metabolism_Homo sapiens_hsa005900.89712447
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89524595
48Intestinal immune network for IgA production_Homo sapiens_hsa046720.88402788
49One carbon pool by folate_Homo sapiens_hsa006700.85917201
50Fatty acid elongation_Homo sapiens_hsa000620.84623716
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83758012
52Butanoate metabolism_Homo sapiens_hsa006500.83736839
53Peroxisome_Homo sapiens_hsa041460.80618135
54Chemical carcinogenesis_Homo sapiens_hsa052040.80445384
55Rheumatoid arthritis_Homo sapiens_hsa053230.79895707
56Pyruvate metabolism_Homo sapiens_hsa006200.75446611
57Autoimmune thyroid disease_Homo sapiens_hsa053200.75131342
58Glutathione metabolism_Homo sapiens_hsa004800.74418570
59Nitrogen metabolism_Homo sapiens_hsa009100.73466938
60Caffeine metabolism_Homo sapiens_hsa002320.71604469
61Vibrio cholerae infection_Homo sapiens_hsa051100.70757008
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70301281
63Hematopoietic cell lineage_Homo sapiens_hsa046400.67574108
64Asthma_Homo sapiens_hsa053100.66301862
65Vitamin digestion and absorption_Homo sapiens_hsa049770.66269325
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65093888
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65038150
68Shigellosis_Homo sapiens_hsa051310.64363896
69Other glycan degradation_Homo sapiens_hsa005110.62075053
70p53 signaling pathway_Homo sapiens_hsa041150.61676500
71Retinol metabolism_Homo sapiens_hsa008300.61106819
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60231814
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60099954
74Antigen processing and presentation_Homo sapiens_hsa046120.58924658
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.58838470
76Metabolic pathways_Homo sapiens_hsa011000.58540329
77Steroid biosynthesis_Homo sapiens_hsa001000.58286823
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56955936
79Regulation of autophagy_Homo sapiens_hsa041400.56196383
80Pentose phosphate pathway_Homo sapiens_hsa000300.56057585
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55548176
82Sulfur relay system_Homo sapiens_hsa041220.54985719
83Legionellosis_Homo sapiens_hsa051340.53554334
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.53501738
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.53018773
86Ether lipid metabolism_Homo sapiens_hsa005650.52202462
87Cardiac muscle contraction_Homo sapiens_hsa042600.51580844
88Basal cell carcinoma_Homo sapiens_hsa052170.51136993
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50773701
90Fat digestion and absorption_Homo sapiens_hsa049750.50582452
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50227736
92Propanoate metabolism_Homo sapiens_hsa006400.50073285
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49942406
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.49581194
95beta-Alanine metabolism_Homo sapiens_hsa004100.49449055
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.48605568
97Herpes simplex infection_Homo sapiens_hsa051680.48474898
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47413758
99Glycerolipid metabolism_Homo sapiens_hsa005610.47083277
100Phagosome_Homo sapiens_hsa041450.45978580
101Measles_Homo sapiens_hsa051620.44730097
102Type I diabetes mellitus_Homo sapiens_hsa049400.44445256
103Galactose metabolism_Homo sapiens_hsa000520.44333180
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.43591651
105Vitamin B6 metabolism_Homo sapiens_hsa007500.43558959
106Tyrosine metabolism_Homo sapiens_hsa003500.43308981
107Sphingolipid metabolism_Homo sapiens_hsa006000.43298910
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43195309
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42424823
110N-Glycan biosynthesis_Homo sapiens_hsa005100.41070709
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40753230
112Biosynthesis of amino acids_Homo sapiens_hsa012300.40576576
113Pertussis_Homo sapiens_hsa051330.40221935
114Linoleic acid metabolism_Homo sapiens_hsa005910.39337682
115Fructose and mannose metabolism_Homo sapiens_hsa000510.38207117
116Fatty acid degradation_Homo sapiens_hsa000710.35595000
117mRNA surveillance pathway_Homo sapiens_hsa030150.34770126
118Hedgehog signaling pathway_Homo sapiens_hsa043400.30863722
119Apoptosis_Homo sapiens_hsa042100.30552833
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30094346
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.30012069
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27753249
123Leishmaniasis_Homo sapiens_hsa051400.27467650
124Lysosome_Homo sapiens_hsa041420.25922831
125Nicotine addiction_Homo sapiens_hsa050330.25498532
126Systemic lupus erythematosus_Homo sapiens_hsa053220.24545892
127Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22825452
128Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.22632372
129Alcoholism_Homo sapiens_hsa050340.21967068
130Salmonella infection_Homo sapiens_hsa051320.21963322
131B cell receptor signaling pathway_Homo sapiens_hsa046620.20466635
132Phototransduction_Homo sapiens_hsa047440.20431748
133Fatty acid metabolism_Homo sapiens_hsa012120.19466785
1342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.18770841
135Malaria_Homo sapiens_hsa051440.17148672
136Tuberculosis_Homo sapiens_hsa051520.16099825
137T cell receptor signaling pathway_Homo sapiens_hsa046600.16079454
138alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15789842
139Arginine and proline metabolism_Homo sapiens_hsa003300.12877985
140Influenza A_Homo sapiens_hsa051640.11230205
141Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.11165390

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