COMMD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.60748253
2DNA deamination (GO:0045006)7.71317801
3transcription from mitochondrial promoter (GO:0006390)7.63619945
4replication fork processing (GO:0031297)6.66205044
5proline metabolic process (GO:0006560)6.62277225
6maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.62296011
7establishment of protein localization to mitochondrial membrane (GO:0090151)5.55754655
8formation of translation preinitiation complex (GO:0001731)5.46985196
9embryonic process involved in female pregnancy (GO:0060136)5.29923239
10viral mRNA export from host cell nucleus (GO:0046784)5.07361868
11positive regulation of protein homooligomerization (GO:0032464)4.94268535
12mitochondrial DNA metabolic process (GO:0032042)4.88314241
13chaperone-mediated protein transport (GO:0072321)4.64142819
14somatic diversification of immune receptors via somatic mutation (GO:0002566)4.57637534
15somatic hypermutation of immunoglobulin genes (GO:0016446)4.57637534
16DNA strand renaturation (GO:0000733)4.51438524
17establishment of apical/basal cell polarity (GO:0035089)4.45783139
18mitotic G1 DNA damage checkpoint (GO:0031571)4.39181468
19GDP-mannose metabolic process (GO:0019673)4.25350881
20cullin deneddylation (GO:0010388)4.23951733
21DNA integration (GO:0015074)4.21182533
22oxidative demethylation (GO:0070989)4.20438551
23regulation of protein homooligomerization (GO:0032462)4.17716172
24telomere maintenance via semi-conservative replication (GO:0032201)4.16849317
25protein maturation by protein folding (GO:0022417)4.16093485
26regulation of integrin activation (GO:0033623)4.14918789
27proteasome assembly (GO:0043248)4.13286726
28maturation of 5.8S rRNA (GO:0000460)4.04811088
29protein deneddylation (GO:0000338)4.01581470
30G1 DNA damage checkpoint (GO:0044783)3.89323632
31mRNA cleavage (GO:0006379)3.87011798
32mitotic G1/S transition checkpoint (GO:0044819)3.86246024
33negative regulation of JAK-STAT cascade (GO:0046426)3.85984802
34mitochondrial RNA metabolic process (GO:0000959)3.85151923
35regulation of mitochondrial translation (GO:0070129)3.84644174
36poly(A)+ mRNA export from nucleus (GO:0016973)3.84310905
37establishment of monopolar cell polarity (GO:0061162)3.81911425
38establishment or maintenance of monopolar cell polarity (GO:0061339)3.81911425
39protein neddylation (GO:0045116)3.78995877
40non-recombinational repair (GO:0000726)3.77009921
41double-strand break repair via nonhomologous end joining (GO:0006303)3.77009921
42rRNA modification (GO:0000154)3.74181578
43negative regulation of ligase activity (GO:0051352)3.72615804
44negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.72615804
45base-excision repair (GO:0006284)3.70247315
46deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.67977298
47DNA strand elongation involved in DNA replication (GO:0006271)3.67734884
48nucleotide-excision repair, DNA gap filling (GO:0006297)3.67721196
49regulation of cellular amino acid metabolic process (GO:0006521)3.67692557
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.64243621
51regulation of double-strand break repair via homologous recombination (GO:0010569)3.61679119
52antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.57705059
53DNA double-strand break processing (GO:0000729)3.56241270
54ribosome biogenesis (GO:0042254)3.56159788
55mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.55388357
56regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.53827995
57telomere maintenance via recombination (GO:0000722)3.48984044
58DNA strand elongation (GO:0022616)3.47458447
59pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.45993325
60pseudouridine synthesis (GO:0001522)3.43840464
61DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.42237519
62base-excision repair, AP site formation (GO:0006285)3.38179645
63negative regulation of cell cycle arrest (GO:0071157)3.36911716
64negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.31333136
65intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.31167308
66signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.31167308
67termination of RNA polymerase II transcription (GO:0006369)3.29268566
68DNA ligation (GO:0006266)3.28624144
69signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.27626027
70signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.27626027
71signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.27626027
72glutamine family amino acid biosynthetic process (GO:0009084)3.27068915
73termination of RNA polymerase III transcription (GO:0006386)3.26437085
74transcription elongation from RNA polymerase III promoter (GO:0006385)3.26437085
75protein complex biogenesis (GO:0070271)3.26339238
76single strand break repair (GO:0000012)3.23954250
77regulation of translational fidelity (GO:0006450)3.22631864
78rRNA processing (GO:0006364)3.20967336
79spliceosomal snRNP assembly (GO:0000387)3.20882511
80positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.19157430
81pyrimidine-containing compound salvage (GO:0008655)3.19058689
82pyrimidine nucleoside salvage (GO:0043097)3.19058689
83cytochrome complex assembly (GO:0017004)3.18201146
84signal transduction involved in DNA damage checkpoint (GO:0072422)3.17891667
85signal transduction involved in DNA integrity checkpoint (GO:0072401)3.17891667
86mitotic nuclear envelope reassembly (GO:0007084)3.17739201
87nuclear envelope reassembly (GO:0031468)3.17739201
88kinetochore assembly (GO:0051382)3.17672660
89spliceosomal tri-snRNP complex assembly (GO:0000244)3.17448660
90mitochondrial respiratory chain complex assembly (GO:0033108)3.14547677
91protein localization to mitochondrion (GO:0070585)3.13969965
92signal transduction involved in cell cycle checkpoint (GO:0072395)3.10524310
93NIK/NF-kappaB signaling (GO:0038061)3.08850340
94rRNA methylation (GO:0031167)3.08849525
95positive regulation of developmental pigmentation (GO:0048087)3.08690708
96ATP synthesis coupled proton transport (GO:0015986)3.08500068
97energy coupled proton transport, down electrochemical gradient (GO:0015985)3.08500068
98mitochondrial DNA replication (GO:0006264)3.07948355
99negative regulation of fatty acid biosynthetic process (GO:0045717)3.07680334
100rRNA metabolic process (GO:0016072)3.06900914
101positive regulation of ligase activity (GO:0051351)3.06087664
102labyrinthine layer development (GO:0060711)3.05189439
103nucleobase biosynthetic process (GO:0046112)3.04491982
104nucleoside salvage (GO:0043174)3.03666656
105translational initiation (GO:0006413)3.02198472
106purine nucleobase biosynthetic process (GO:0009113)3.01715175
107negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.00626447
108negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.98857307
109telomere maintenance via telomere lengthening (GO:0010833)2.96878852
110ribonucleoprotein complex biogenesis (GO:0022613)2.94726559
111cellular response to ATP (GO:0071318)2.94717192
112positive regulation of chromosome segregation (GO:0051984)2.91611576
113respiratory chain complex IV assembly (GO:0008535)2.91068290
114positive regulation of DNA repair (GO:0045739)2.90828271
115positive regulation of mitotic sister chromatid separation (GO:1901970)2.89514076
116positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.89514076
117positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.89514076
118meiotic chromosome segregation (GO:0045132)2.89480808
119mitotic recombination (GO:0006312)2.89212672
120metallo-sulfur cluster assembly (GO:0031163)2.88896758
121iron-sulfur cluster assembly (GO:0016226)2.88896758
122mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.88646966
123mitochondrial respiratory chain complex I assembly (GO:0032981)2.88646966
124NADH dehydrogenase complex assembly (GO:0010257)2.88646966
125embryonic placenta development (GO:0001892)2.88581879
126regulation of ubiquitin-protein transferase activity (GO:0051438)2.87169416
127L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.87139556
128respiratory electron transport chain (GO:0022904)2.86609893
129trophectodermal cell differentiation (GO:0001829)2.85641947
130resolution of meiotic recombination intermediates (GO:0000712)2.84991625
131transcription-coupled nucleotide-excision repair (GO:0006283)2.83885459
132negative regulation of Ras GTPase activity (GO:0034261)2.83884355
133antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.81908269
134positive regulation by host of viral transcription (GO:0043923)2.81754923
135negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.80554423
136negative regulation of protein ubiquitination (GO:0031397)2.80146515
137response to peptidoglycan (GO:0032494)2.79887692
138nucleobase-containing small molecule interconversion (GO:0015949)2.78974708
139establishment of protein localization to mitochondrion (GO:0072655)2.78900784
140protein targeting to mitochondrion (GO:0006626)2.78730931
141electron transport chain (GO:0022900)2.78088855
142positive regulation of prostaglandin secretion (GO:0032308)2.78030223
143GTP biosynthetic process (GO:0006183)2.77891859
144regulation of ligase activity (GO:0051340)2.77548775
145pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.75619869
146regulation of cellular amine metabolic process (GO:0033238)2.72023531
147positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.71936546
148anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.71236612
149nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.70219001
150regulation of RNA export from nucleus (GO:0046831)2.69772055
151mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.69388222
152guanosine-containing compound biosynthetic process (GO:1901070)2.69248116
153regulation of double-strand break repair (GO:2000779)2.68214672
154L-methionine salvage (GO:0071267)2.67834850
155L-methionine biosynthetic process (GO:0071265)2.67834850
156amino acid salvage (GO:0043102)2.67834850
157oxidative phosphorylation (GO:0006119)2.67258969
158negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.66982590
159deoxyribose phosphate biosynthetic process (GO:0046385)2.66816875
1602-deoxyribonucleotide biosynthetic process (GO:0009265)2.66816875
161negative regulation of myeloid cell apoptotic process (GO:0033033)2.64786776
162pentose metabolic process (GO:0019321)2.64119006
163establishment of viral latency (GO:0019043)2.61795450
1647-methylguanosine mRNA capping (GO:0006370)2.60969264
165peptidyl-histidine modification (GO:0018202)2.60613588
166regulation of superoxide anion generation (GO:0032928)2.59956165
167amino sugar catabolic process (GO:0046348)2.59788361
168positive regulation of cell cycle arrest (GO:0071158)2.59338517
169activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.58594085
170nucleotide salvage (GO:0043173)2.57144715
171ATP hydrolysis coupled proton transport (GO:0015991)2.56346622
172energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.56346622
173deoxyribonucleotide catabolic process (GO:0009264)2.56192102
174negative regulation of mitochondrion organization (GO:0010823)2.54996631
175negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.54757779
176phagosome maturation (GO:0090382)2.53591522
177UTP biosynthetic process (GO:0006228)2.52484793
178viral protein processing (GO:0019082)2.52331711
179RNA capping (GO:0036260)2.50666797
1807-methylguanosine RNA capping (GO:0009452)2.50666797
181deoxyribose phosphate catabolic process (GO:0046386)2.49749306
182DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.49547224
183inner mitochondrial membrane organization (GO:0007007)2.49255756

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse3.87583873
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.27386570
3* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.23341101
4MYC_18358816_ChIP-ChIP_MESCs_Mouse3.02194739
5MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93271408
6ETS1_20019798_ChIP-Seq_JURKAT_Human2.84182979
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.82052076
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.66985470
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61149075
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.60551765
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.55406862
12E2F7_22180533_ChIP-Seq_HELA_Human2.49548137
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.45697081
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.45680888
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.39363695
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.39363695
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.39363695
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.34252603
19E2F1_18555785_ChIP-Seq_MESCs_Mouse2.16595691
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.15275923
21YY1_21170310_ChIP-Seq_MESCs_Mouse2.13648281
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.10691729
23* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.10394221
24NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.03239147
25NANOG_18555785_ChIP-Seq_MESCs_Mouse2.02859195
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.02320348
27CREB1_15753290_ChIP-ChIP_HEK293T_Human2.01916432
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.01405688
29POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.00140337
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.98894375
31KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.98468074
32* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.96421590
33DCP1A_22483619_ChIP-Seq_HELA_Human1.91721115
34* GABP_19822575_ChIP-Seq_HepG2_Human1.89752159
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89637012
36* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.88262153
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.86180529
38XRN2_22483619_ChIP-Seq_HELA_Human1.81673304
39SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.80612036
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.79044174
41* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78882765
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.76340364
43VDR_23849224_ChIP-Seq_CD4+_Human1.72757245
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72238360
45FOXM1_23109430_ChIP-Seq_U2OS_Human1.69780874
46* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69277666
47* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.68361035
48* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67486884
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67388671
50NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.66659219
51TTF2_22483619_ChIP-Seq_HELA_Human1.63863193
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.61243751
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60335041
54* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59107218
55* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57214968
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56459869
57TCF3_18692474_ChIP-Seq_MEFs_Mouse1.56175882
58VDR_21846776_ChIP-Seq_THP-1_Human1.55948445
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.55251850
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55214747
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.52175697
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.51895424
63TCF3_18692474_ChIP-Seq_MESCs_Mouse1.51456629
64BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.50867104
65IRF8_21731497_ChIP-ChIP_J774_Mouse1.50847503
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50227953
67NANOG_21062744_ChIP-ChIP_HESCs_Human1.50027195
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48086602
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.47831718
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.47408284
71* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46310270
72NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.45289037
73* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.44039212
74POU5F1_16518401_ChIP-PET_MESCs_Mouse1.43864497
75* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40085213
76KDM5A_27292631_Chip-Seq_BREAST_Human1.39094347
77SPI1_23547873_ChIP-Seq_NB4_Human1.37274796
78STAT4_19710469_ChIP-ChIP_TH1__Mouse1.36574006
79BP1_19119308_ChIP-ChIP_Hs578T_Human1.36530747
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32161125
81MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.30785124
82SOX2_18692474_ChIP-Seq_MEFs_Mouse1.30713986
83IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30347093
84* TET1_21451524_ChIP-Seq_MESCs_Mouse1.30073620
85HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.29213423
86* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.27810949
87SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26338161
88FOXP3_21729870_ChIP-Seq_TREG_Human1.25177698
89CIITA_25753668_ChIP-Seq_RAJI_Human1.24915149
90RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22068980
91* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.20930111
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.20209620
93ZNF263_19887448_ChIP-Seq_K562_Human1.19569871
94SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19295610
95IRF8_22096565_ChIP-ChIP_GC-B_Human1.17962757
96SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17249152
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16924780
98CTCF_18555785_ChIP-Seq_MESCs_Mouse1.16843315
99ELK3_25401928_ChIP-Seq_HUVEC_Human1.14756448
100SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13772877
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13498906
102CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13377633
103KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13359492
104ELF1_20517297_ChIP-Seq_JURKAT_Human1.13031405
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12173546
106ERG_21242973_ChIP-ChIP_JURKAT_Human1.11924234
107SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11085503
108CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10299897
109PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09718430
110SOX2_18692474_ChIP-Seq_MESCs_Mouse1.09508510
111ELK1_19687146_ChIP-ChIP_HELA_Human1.09073624
112YY1_22570637_ChIP-Seq_MALME-3M_Human1.09018239
113NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.08104750
114MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07596974
115BCL6_27268052_Chip-Seq_Bcells_Human1.07571192
116ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.07116205
117TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06908300
118CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.06672267
119MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06516376
120TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06172345
121MYC_22102868_ChIP-Seq_BL_Human1.06165812
122* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05825441
123ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05533533
124NANOG_18692474_ChIP-Seq_MEFs_Mouse1.05120789
125LXR_22292898_ChIP-Seq_THP-1_Human1.04227012
126NANOG_18692474_ChIP-Seq_MESCs_Mouse1.03026119
127TFEB_21752829_ChIP-Seq_HELA_Human1.02903483
128TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.02683590
129RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02045737
130SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01653576
131CTCF_26484167_Chip-Seq_Bcells_Mouse1.00956816
132ELK1_22589737_ChIP-Seq_MCF10A_Human1.00840959
133CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00547940
134YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00258076
135ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99979325
136* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99840076
137E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99488264
138CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99472312
139MAF_26560356_Chip-Seq_TH2_Human0.99061185
140RXRA_24833708_ChIP-Seq_LIVER_Mouse0.99051338
141FOXP1_21924763_ChIP-Seq_HESCs_Human0.98799793
142EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.98626141
143* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98594440
144MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96926576

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.10259441
2MP0005171_absent_coat_pigmentation3.98844254
3MP0003693_abnormal_embryo_hatching3.62496770
4MP0010030_abnormal_orbit_morphology3.49363017
5MP0004957_abnormal_blastocyst_morpholog3.40328485
6MP0009278_abnormal_bone_marrow3.20144015
7MP0010094_abnormal_chromosome_stability3.13870635
8MP0004233_abnormal_muscle_weight3.08176218
9MP0002148_abnormal_hypersensitivity_rea2.93732714
10MP0003436_decreased_susceptibility_to2.91975385
11MP0003191_abnormal_cellular_cholesterol2.86095022
12MP0003111_abnormal_nucleus_morphology2.79202141
13MP0003786_premature_aging2.72547858
14MP0009785_altered_susceptibility_to2.67296423
15MP0003718_maternal_effect2.53125224
16MP0008058_abnormal_DNA_repair2.46684134
17MP0001853_heart_inflammation2.42503631
18MP0006082_CNS_inflammation2.37992916
19MP0008932_abnormal_embryonic_tissue2.37674709
20MP0000343_altered_response_to2.36903372
21MP0008995_early_reproductive_senescence2.32097355
22MP0003724_increased_susceptibility_to2.30796128
23MP0002653_abnormal_ependyma_morphology2.26996679
24MP0003077_abnormal_cell_cycle2.24381261
25MP0003303_peritoneal_inflammation2.12083554
26MP0005451_abnormal_body_composition2.11224082
27MP0001835_abnormal_antigen_presentation2.09988197
28MP0005000_abnormal_immune_tolerance2.08215663
29MP0002009_preneoplasia2.07399036
30MP0004133_heterotaxia2.05786051
31MP0002419_abnormal_innate_immunity2.04955962
32MP0005671_abnormal_response_to2.03527948
33MP0005025_abnormal_response_to1.95486336
34MP0003890_abnormal_embryonic-extraembry1.94699480
35MP0001545_abnormal_hematopoietic_system1.90613788
36MP0005397_hematopoietic_system_phenotyp1.90613788
37MP0008877_abnormal_DNA_methylation1.90161105
38MP0000685_abnormal_immune_system1.87046330
39MP0006072_abnormal_retinal_apoptosis1.84555556
40MP0003075_altered_response_to1.78691617
41MP0002452_abnormal_antigen_presenting1.78406676
42MP0003119_abnormal_digestive_system1.76747821
43MP0002723_abnormal_immune_serum1.74134346
44MP0001697_abnormal_embryo_size1.72253797
45MP0003806_abnormal_nucleotide_metabolis1.72224510
46MP0004510_myositis1.71983546
47MP0001790_abnormal_immune_system1.69959852
48MP0005387_immune_system_phenotype1.69959852
49MP0005058_abnormal_lysosome_morphology1.68060280
50MP0001293_anophthalmia1.67648009
51MP0005075_abnormal_melanosome_morpholog1.65814770
52MP0006035_abnormal_mitochondrial_morpho1.63690573
53MP0001730_embryonic_growth_arrest1.60436417
54MP0009764_decreased_sensitivity_to1.60148025
55MP0001533_abnormal_skeleton_physiology1.58301755
56MP0001845_abnormal_inflammatory_respons1.51978304
57MP0001819_abnormal_immune_cell1.51476458
58MP0002420_abnormal_adaptive_immunity1.50425774
59MP0005174_abnormal_tail_pigmentation1.49960955
60MP0008469_abnormal_protein_level1.48983634
61MP0002086_abnormal_extraembryonic_tissu1.47207235
62MP0002084_abnormal_developmental_patter1.44816599
63MP0001800_abnormal_humoral_immune1.44710879
64MP0002085_abnormal_embryonic_tissue1.43743714
65MP0005380_embryogenesis_phenotype1.42232222
66MP0001672_abnormal_embryogenesis/_devel1.42232222
67MP0002277_abnormal_respiratory_mucosa1.41700882
68MP0002254_reproductive_system_inflammat1.41425970
69MP0005464_abnormal_platelet_physiology1.40943003
70MP0002837_dystrophic_cardiac_calcinosis1.40535485
71MP0003567_abnormal_fetal_cardiomyocyte1.39242403
72MP0000858_altered_metastatic_potential1.37902248
73MP0002405_respiratory_system_inflammati1.36916625
74MP0009840_abnormal_foam_cell1.36382057
75MP0003283_abnormal_digestive_organ1.36095286
76MP0000350_abnormal_cell_proliferation1.36012295
77MP0000490_abnormal_crypts_of1.35193037
78MP0003136_yellow_coat_color1.34968365
79MP0002877_abnormal_melanocyte_morpholog1.28646730
80MP0003453_abnormal_keratinocyte_physiol1.27710052
81MP0002080_prenatal_lethality1.26793852
82MP0005310_abnormal_salivary_gland1.25233263
83MP0000604_amyloidosis1.23136070
84MP0000015_abnormal_ear_pigmentation1.22611806
85MP0002269_muscular_atrophy1.21315703
86MP0004197_abnormal_fetal_growth/weight/1.18933652
87MP0005165_increased_susceptibility_to1.16425139
88MP0003656_abnormal_erythrocyte_physiolo1.15049344
89MP0000716_abnormal_immune_system1.14994314
90MP0002796_impaired_skin_barrier1.14837300
91MP0005266_abnormal_metabolism1.13358855
92MP0002282_abnormal_trachea_morphology1.13231934
93MP0009333_abnormal_splenocyte_physiolog1.12630380
94MP0000750_abnormal_muscle_regeneration1.12316703
95MP0002249_abnormal_larynx_morphology1.10806875
96MP0001542_abnormal_bone_strength1.10137364
97MP0000371_diluted_coat_color1.10086230
98MP0002429_abnormal_blood_cell1.09904502
99MP0000689_abnormal_spleen_morphology1.08356205
100MP0001727_abnormal_embryo_implantation1.06970935
101MP0003984_embryonic_growth_retardation1.06932164
102MP0004947_skin_inflammation1.04919041
103MP0000462_abnormal_digestive_system1.04782518
104MP0002111_abnormal_tail_morphology1.04720549
105MP0002019_abnormal_tumor_incidence1.03879775
106MP0002722_abnormal_immune_system1.03458235
107MP0000579_abnormal_nail_morphology1.03412212
108MP0002088_abnormal_embryonic_growth/wei1.03003537
109MP0002398_abnormal_bone_marrow1.00733217
110MP0003448_altered_tumor_morphology1.00599583
111MP0005395_other_phenotype1.00174237
112MP0010352_gastrointestinal_tract_polyps0.99764419
113MP0000313_abnormal_cell_death0.98999329
114MP0003123_paternal_imprinting0.98166743
115MP0000470_abnormal_stomach_morphology0.97452714
116MP0005085_abnormal_gallbladder_physiolo0.96826660
117MP0006036_abnormal_mitochondrial_physio0.94081454
118MP0010155_abnormal_intestine_physiology0.93733478
119MP0004019_abnormal_vitamin_homeostasis0.93662984
120MP0005584_abnormal_enzyme/coenzyme_acti0.92968160
121MP0000639_abnormal_adrenal_gland0.92458464
122MP0005319_abnormal_enzyme/_coenzyme0.92275950
123MP0004142_abnormal_muscle_tone0.92180127
124MP0001145_abnormal_male_reproductive0.91622292
125MP0009763_increased_sensitivity_to0.91585535
126MP0005166_decreased_susceptibility_to0.90423978
127MP0001340_abnormal_eyelid_morphology0.87487803
128MP0005076_abnormal_cell_differentiation0.87067571
129MP0005365_abnormal_bile_salt0.85936194
130MP0001905_abnormal_dopamine_level0.84565333
131MP0005332_abnormal_amino_acid0.84164447
132MP0003221_abnormal_cardiomyocyte_apopto0.84080348
133MP0003828_pulmonary_edema0.82455473
134MP0000762_abnormal_tongue_morphology0.81238667
135MP0003941_abnormal_skin_development0.80854890
136MP0001764_abnormal_homeostasis0.79669113
137MP0002332_abnormal_exercise_endurance0.78844677
138MP0002938_white_spotting0.78661873
139MP0005501_abnormal_skin_physiology0.77028372
140MP0000358_abnormal_cell_content/0.76720659
141MP0000372_irregular_coat_pigmentation0.76393287
142MP0009765_abnormal_xenobiotic_induced0.76126333
143MP0003186_abnormal_redox_activity0.75928082
144MP0001186_pigmentation_phenotype0.75181069
145MP0002075_abnormal_coat/hair_pigmentati0.73673632
146MP0003646_muscle_fatigue0.73560668
147MP0002132_abnormal_respiratory_system0.73520157
148MP0002998_abnormal_bone_remodeling0.72569986
149MP0002210_abnormal_sex_determination0.72291413
150MP0003329_amyloid_beta_deposits0.72157516
151MP0003172_abnormal_lysosome_physiology0.70389124
152MP0000609_abnormal_liver_physiology0.69704034
153MP0008007_abnormal_cellular_replicative0.69606397
154MP0000703_abnormal_thymus_morphology0.69572577
155MP0005084_abnormal_gallbladder_morpholo0.69479253
156MP0005408_hypopigmentation0.69360953
157MP0003763_abnormal_thymus_physiology0.68618031
158MP0005390_skeleton_phenotype0.68600546
159MP0008260_abnormal_autophagy0.67485138
160MP0005376_homeostasis/metabolism_phenot0.67272669
161MP0001929_abnormal_gametogenesis0.66099602
162MP0000653_abnormal_sex_gland0.65945211
163MP0005330_cardiomyopathy0.65595838
164MP0004264_abnormal_extraembryonic_tissu0.65190529
165MP0005367_renal/urinary_system_phenotyp0.62680753
166MP0000516_abnormal_urinary_system0.62680753
167MP0002163_abnormal_gland_morphology0.62611964
168MP0002114_abnormal_axial_skeleton0.62041209

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)5.13075235
2Pustule (HP:0200039)4.69869329
3Rib fusion (HP:0000902)4.49287850
4Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.49217912
5Abnormality of liposaccharide metabolism (HP:0010968)4.48992274
6Abnormality of glycosphingolipid metabolism (HP:0004343)4.48992274
7Abnormality of glycolipid metabolism (HP:0010969)4.48992274
8Rectal fistula (HP:0100590)4.39127903
9Rectovaginal fistula (HP:0000143)4.39127903
10Facial hemangioma (HP:0000329)4.38927318
11Acute necrotizing encephalopathy (HP:0006965)4.38257448
12Abnormal mitochondria in muscle tissue (HP:0008316)4.21004045
13Vacuolated lymphocytes (HP:0001922)4.11027154
14Increased IgM level (HP:0003496)4.05994843
15Mitochondrial inheritance (HP:0001427)4.02108074
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.01827828
17Decreased activity of mitochondrial respiratory chain (HP:0008972)4.01827828
18Acute encephalopathy (HP:0006846)3.92117968
19Absent radius (HP:0003974)3.89353623
20Vaginal fistula (HP:0004320)3.85527200
21Tongue fasciculations (HP:0001308)3.80242043
22Alopecia of scalp (HP:0002293)3.74629894
23Annular pancreas (HP:0001734)3.72605786
24Intestinal fistula (HP:0100819)3.71129479
25Increased CSF lactate (HP:0002490)3.69865812
26Hepatocellular necrosis (HP:0001404)3.69644284
27Dysautonomia (HP:0002459)3.68635929
28Absent forearm bone (HP:0003953)3.64211624
29Aplasia involving forearm bones (HP:0009822)3.64211624
30Poikiloderma (HP:0001029)3.58286365
31Aplasia/hypoplasia of the humerus (HP:0006507)3.49770390
32Cerebral hypomyelination (HP:0006808)3.49531502
33Progressive macrocephaly (HP:0004481)3.45174464
34Muscle fibrillation (HP:0010546)3.45064811
35Squamous cell carcinoma (HP:0002860)3.33786709
36Absent thumb (HP:0009777)3.33529333
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.32444616
38Renal Fanconi syndrome (HP:0001994)3.31085815
39Turricephaly (HP:0000262)3.30297152
40Abnormal hemoglobin (HP:0011902)3.28347410
41Loss of speech (HP:0002371)3.26446951
42Hepatic necrosis (HP:0002605)3.22353825
43Patellar aplasia (HP:0006443)3.21554317
44Breast hypoplasia (HP:0003187)3.20587901
45Short humerus (HP:0005792)3.20060175
46Increased cerebral lipofuscin (HP:0011813)3.19132533
47Increased hepatocellular lipid droplets (HP:0006565)3.17342870
48Increased intramyocellular lipid droplets (HP:0012240)3.17342435
49Lipid accumulation in hepatocytes (HP:0006561)3.12782207
50Hepatosplenomegaly (HP:0001433)3.12514012
51Coronal craniosynostosis (HP:0004440)3.07617093
52Orthostatic hypotension (HP:0001278)3.07252691
53Abnormality of macrophages (HP:0004311)3.06984089
54Type I transferrin isoform profile (HP:0003642)3.05023772
55Aplasia/Hypoplasia of the patella (HP:0006498)3.00925612
56Ulnar bowing (HP:0003031)3.00481129
57Male infertility (HP:0003251)3.00308295
58Increased muscle lipid content (HP:0009058)2.99143230
59Premature graying of hair (HP:0002216)2.96446340
60Intestinal atresia (HP:0011100)2.95596187
61Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.94179199
62Increased serum lactate (HP:0002151)2.88983858
63Hypochromic microcytic anemia (HP:0004840)2.88166221
64Increased neuronal autofluorescent lipopigment (HP:0002074)2.87415677
65Petechiae (HP:0000967)2.86578776
66Lactic acidosis (HP:0003128)2.84338722
67Abnormality of the aortic arch (HP:0012303)2.79733625
68Alacrima (HP:0000522)2.79518635
69Cerebral edema (HP:0002181)2.79235623
70Abnormality of male internal genitalia (HP:0000022)2.78572922
71Aplasia of the musculature (HP:0100854)2.78275123
72Short chin (HP:0000331)2.76523812
73Selective tooth agenesis (HP:0001592)2.74248083
74Abnormal trabecular bone morphology (HP:0100671)2.72301568
75Abnormal protein glycosylation (HP:0012346)2.71805008
76Abnormal glycosylation (HP:0012345)2.71805008
77Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.71805008
78Abnormal protein N-linked glycosylation (HP:0012347)2.71805008
79Respiratory failure (HP:0002878)2.69705002
80Anteriorly placed anus (HP:0001545)2.68358948
81Aplasia/Hypoplasia involving the musculature (HP:0001460)2.66098213
82Abnormality of the labia minora (HP:0012880)2.65995842
83Diaphragmatic weakness (HP:0009113)2.65725646
84Hypoplasia of the radius (HP:0002984)2.64097203
85Exertional dyspnea (HP:0002875)2.62991225
86Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.62375119
87Vertebral hypoplasia (HP:0008417)2.62375119
88Large for gestational age (HP:0001520)2.62327091
89Broad alveolar ridges (HP:0000187)2.57521004
90Ragged-red muscle fibers (HP:0003200)2.56937790
91Progressive neurologic deterioration (HP:0002344)2.56025673
92Congenital hip dislocation (HP:0001374)2.54279436
93Exercise intolerance (HP:0003546)2.52585894
94Albinism (HP:0001022)2.51109535
95Hypokinesia (HP:0002375)2.48601113
96Premature skin wrinkling (HP:0100678)2.47891766
97Recurrent abscess formation (HP:0002722)2.46853871
98Prolonged neonatal jaundice (HP:0006579)2.44792353
99Muscle fiber atrophy (HP:0100295)2.42912964
100Capillary hemangiomas (HP:0005306)2.39986392
101Abnormality of cells of the erythroid lineage (HP:0012130)2.38444232
102Increased serum ferritin (HP:0003281)2.36553411
103Birth length less than 3rd percentile (HP:0003561)2.35963465
104Reduced antithrombin III activity (HP:0001976)2.35123311
105Choanal stenosis (HP:0000452)2.34172829
106Cutaneous melanoma (HP:0012056)2.32340114
107Bifid uvula (HP:0000193)2.31196735
108Respiratory difficulties (HP:0002880)2.30994858
109Hypotrichosis (HP:0001006)2.30746114
110Microvesicular hepatic steatosis (HP:0001414)2.29283098
111Type 2 muscle fiber atrophy (HP:0003554)2.29278774
112Abnormality of placental membranes (HP:0011409)2.28811566
113Amniotic constriction ring (HP:0009775)2.28811566
114Mediastinal lymphadenopathy (HP:0100721)2.28004144
115Aplasia/Hypoplasia of the sacrum (HP:0008517)2.26774149
116Abnormal number of erythroid precursors (HP:0012131)2.26180695
117Basal cell carcinoma (HP:0002671)2.25836247
118Abnormality of aromatic amino acid family metabolism (HP:0004338)2.25756272
119Pancreatic islet-cell hyperplasia (HP:0004510)2.24585030
120Systemic lupus erythematosus (HP:0002725)2.22573501
121Vertebral compression fractures (HP:0002953)2.21163576
122Abnormality of polysaccharide metabolism (HP:0011012)2.19449466
123Abnormality of glycosaminoglycan metabolism (HP:0004371)2.19449466
124Abnormality of mucopolysaccharide metabolism (HP:0011020)2.19449466
125Axonal loss (HP:0003447)2.19256145
1263-Methylglutaconic aciduria (HP:0003535)2.19247313
127Cholecystitis (HP:0001082)2.18403448
128Abnormal gallbladder physiology (HP:0012438)2.18403448
129Recurrent bacterial skin infections (HP:0005406)2.17125031
130Abnormality of the ileum (HP:0001549)2.16877874
131Hypertensive crisis (HP:0100735)2.16842729
132Abnormal autonomic nervous system physiology (HP:0012332)2.16605825
133Rough bone trabeculation (HP:0100670)2.16134187
134Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.15684602
135Stomatitis (HP:0010280)2.14171614
136Degeneration of anterior horn cells (HP:0002398)2.12990595
137Abnormality of the anterior horn cell (HP:0006802)2.12990595
138Amelogenesis imperfecta (HP:0000705)2.12908550
139Premature ovarian failure (HP:0008209)2.12609308
140Methylmalonic aciduria (HP:0012120)2.12543652
141Upper motor neuron abnormality (HP:0002127)2.11574910
142Opisthotonus (HP:0002179)2.10065193
143Dysostosis multiplex (HP:0000943)2.09487803
144Nuclear cataract (HP:0100018)2.08795486
145Polycythemia (HP:0001901)2.07240663
146Urinary glycosaminoglycan excretion (HP:0003541)2.05767113
147Mucopolysacchariduria (HP:0008155)2.05767113
148Redundant skin (HP:0001582)2.05244942
149Joint stiffness (HP:0001387)2.04918628
150Mutism (HP:0002300)2.03831019
151Multiple enchondromatosis (HP:0005701)2.02879029
152Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.02576541
153Growth hormone excess (HP:0000845)2.01580898
154Aplastic anemia (HP:0001915)2.00055672
155Microretrognathia (HP:0000308)1.99553594
156Decreased lacrimation (HP:0000633)1.98795383
157Abnormality of the umbilical cord (HP:0010881)1.98636739
158Hypoplasia of the ulna (HP:0003022)1.97629233
159Clumsiness (HP:0002312)1.96698439
160Carpal bone hypoplasia (HP:0001498)1.92282160
161Lethargy (HP:0001254)1.92036524
162Oral leukoplakia (HP:0002745)1.91872287
163Aplasia/Hypoplasia of the ulna (HP:0006495)1.91359889
164Nausea (HP:0002018)1.90969840
165Gastrointestinal atresia (HP:0002589)1.90871853
166IgA deficiency (HP:0002720)1.90666710
167Pancytopenia (HP:0001876)1.89022577
168Emotional lability (HP:0000712)1.88458055
169Fasciculations (HP:0002380)1.87422636
170Median cleft lip (HP:0000161)1.87240459
171Progressive muscle weakness (HP:0003323)1.87235068
172Death in infancy (HP:0001522)1.86544141
173Hypochromic anemia (HP:0001931)1.86450201
174Premature loss of primary teeth (HP:0006323)1.85755654
175Popliteal pterygium (HP:0009756)1.85122030
176CNS demyelination (HP:0007305)1.84521069
177Optic disc pallor (HP:0000543)1.83295408
178Testicular atrophy (HP:0000029)1.81516767
179Hypotelorism (HP:0000601)1.80043232
180Obstructive lung disease (HP:0006536)1.80006862
181Chronic obstructive pulmonary disease (HP:0006510)1.80006862
182Abnormal number of incisors (HP:0011064)1.78302475
183Increased serum pyruvate (HP:0003542)1.77523951
184Impulsivity (HP:0100710)1.77422339
185Hamartoma (HP:0010566)1.76821153
186Reticulocytopenia (HP:0001896)1.76529269
187Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75842613
188Dicarboxylic aciduria (HP:0003215)1.75842613

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.80908678
2MAPK154.63414855
3DDR24.16434223
4MAP3K63.77953695
5MAP3K113.58806390
6IRAK33.55241344
7BUB13.41553495
8PINK13.20065271
9TESK13.11148189
10PIM22.92454972
11VRK22.87179374
12MATK2.62366020
13AKT32.57375675
14FGR2.57316231
15WEE12.50004123
16TYRO32.18152419
17DAPK12.14843425
18YES11.99681830
19MST41.95866775
20UHMK11.92880046
21SIK31.91600221
22LIMK11.87904037
23CDK71.86014580
24ABL21.74488826
25PRKD21.70829223
26TRIM281.68005641
27DYRK31.67698966
28DYRK1B1.67690699
29ERN11.61679876
30EPHA21.58370110
31LATS21.57226112
32PAK41.54161669
33TBK11.51187177
34NME21.50888086
35BMX1.49297998
36CSK1.48408004
37PBK1.46292781
38PLK11.45516652
39MAP3K31.35464171
40PIM11.31872237
41KDR1.29229418
42IKBKB1.27921802
43BRSK21.27363197
44MAP3K121.26822713
45CHEK21.22268942
46ZAK1.17913876
47MAP3K141.09178309
48PDGFRA1.06071787
49RPS6KC11.02151579
50RPS6KL11.02151579
51STK161.00874061
52BCKDK1.00352460
53MAP2K30.99774665
54IRAK40.97796468
55AURKA0.97407596
56TESK20.95657030
57TAOK10.91232824
58PLK40.90472970
59TAOK20.90383246
60GSK3A0.90093506
61MAP4K10.89243876
62TYK20.88577097
63NEK20.88102178
64ILK0.87358084
65RPS6KA60.86843620
66DYRK20.86715397
67RAF10.84715800
68CDC42BPA0.83017442
69GRK70.82451482
70SMG10.81306841
71CDK60.78725556
72MAPKAPK30.76316121
73TRPM70.76013793
74TXK0.75325769
75TTK0.75103729
76CSNK2A10.73991723
77PHKG10.73442214
78PHKG20.73442214
79EIF2AK10.70117332
80RPS6KB20.69902097
81IKBKE0.69584802
82ATR0.68825126
83STK100.68173751
84SIK10.67263405
85MAPK110.66577172
86DAPK30.66431508
87MAP2K70.66015595
88BRSK10.65463663
89TGFBR20.65087306
90AURKB0.64326336
91NEK10.61741555
92RPS6KA50.61010149
93CSNK1A1L0.59624489
94MUSK0.59184480
95TLK10.58675748
96MAP2K20.58327415
97GRK60.58319669
98ARAF0.58266053
99CSNK1G10.57331372
100CSNK2A20.57324954
101PAK10.56963400
102ACVR1B0.56589801
103CAMK2B0.55541651
104CAMK2G0.53822757
105MOS0.51571809
106CDK20.51357888
107SRPK10.49754305
108RPS6KA10.48416099
109VRK10.47957343
110MAP3K50.46909466
111PRKAA10.46907599
112CSNK1G20.46608188
113EIF2AK30.45974879
114CDC70.45061124
115PRPF4B0.44230776
116PDK40.43400296
117PDK30.43400296
118SCYL20.43306027
119RPS6KA40.42860093
120CHEK10.42804888
121MTOR0.39881347
122LYN0.38841427
123LRRK20.37285319
124RIPK40.37173515
125TSSK60.37112552
126MAP3K80.36320926
127MARK30.36229943
128EIF2AK20.35867231
129BRAF0.35469421
130PRKCI0.35262008
131CSF1R0.34775467
132MAPK40.34432080
133STK38L0.33749438
134HIPK20.32350241
135STK30.32174710
136CDK190.31977097
137NME10.31924334
138STK40.31790139
139CAMK2D0.30219766
140CCNB10.30170454
141MAPKAPK20.29866681
142CDK80.28617207
143CDK10.27977453
144CHUK0.27832091
145CSNK1G30.26945637
146BLK0.26136732
147MAP3K90.26051733
148CDK11A0.25600399
149PLK30.25538747
150PRKG20.24839106
151MAPK30.24657831
152ATM0.23049755
153PDK20.22687309
154EGFR0.22243094
155CDK150.22169211

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.46706022
2Base excision repair_Homo sapiens_hsa034104.13657201
3DNA replication_Homo sapiens_hsa030303.89427860
4Proteasome_Homo sapiens_hsa030503.44779497
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.32350771
6Ribosome_Homo sapiens_hsa030103.20777192
7Fatty acid biosynthesis_Homo sapiens_hsa000613.09258168
8RNA polymerase_Homo sapiens_hsa030202.93803506
9Spliceosome_Homo sapiens_hsa030402.72100221
10RNA transport_Homo sapiens_hsa030132.58298648
11Nucleotide excision repair_Homo sapiens_hsa034202.55763872
12Homologous recombination_Homo sapiens_hsa034402.29935396
13Folate biosynthesis_Homo sapiens_hsa007902.17918256
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.05402274
15Sulfur relay system_Homo sapiens_hsa041222.04583562
16Other glycan degradation_Homo sapiens_hsa005111.84200904
17Fanconi anemia pathway_Homo sapiens_hsa034601.83780351
18Collecting duct acid secretion_Homo sapiens_hsa049661.80954000
19Pyrimidine metabolism_Homo sapiens_hsa002401.80221098
20Vitamin B6 metabolism_Homo sapiens_hsa007501.77407924
21Arginine and proline metabolism_Homo sapiens_hsa003301.73849315
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.73468514
23Rheumatoid arthritis_Homo sapiens_hsa053231.70158222
24Sulfur metabolism_Homo sapiens_hsa009201.66655003
25Cell cycle_Homo sapiens_hsa041101.61811347
26Biosynthesis of amino acids_Homo sapiens_hsa012301.59619411
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.56533584
28mRNA surveillance pathway_Homo sapiens_hsa030151.48125741
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47217063
30p53 signaling pathway_Homo sapiens_hsa041151.46423122
31Vibrio cholerae infection_Homo sapiens_hsa051101.44217492
32Oxidative phosphorylation_Homo sapiens_hsa001901.38630376
33Fructose and mannose metabolism_Homo sapiens_hsa000511.24775187
34Circadian rhythm_Homo sapiens_hsa047101.24591449
35Parkinsons disease_Homo sapiens_hsa050121.23784904
36Basal transcription factors_Homo sapiens_hsa030221.23248636
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.22947781
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19093772
39Huntingtons disease_Homo sapiens_hsa050161.12841269
40Glutathione metabolism_Homo sapiens_hsa004801.12819509
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12353616
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.11213145
43Hedgehog signaling pathway_Homo sapiens_hsa043401.10220678
44Allograft rejection_Homo sapiens_hsa053301.09078293
45One carbon pool by folate_Homo sapiens_hsa006701.07888132
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07410929
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06238224
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.00199719
49Hippo signaling pathway_Homo sapiens_hsa043900.99689096
50Asthma_Homo sapiens_hsa053100.99279456
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97759557
52Antigen processing and presentation_Homo sapiens_hsa046120.97043420
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95476697
54Steroid biosynthesis_Homo sapiens_hsa001000.93114083
55Graft-versus-host disease_Homo sapiens_hsa053320.92597048
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92162503
57Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91167940
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90998191
59Osteoclast differentiation_Homo sapiens_hsa043800.89729034
60Salmonella infection_Homo sapiens_hsa051320.89714612
61Phagosome_Homo sapiens_hsa041450.89395194
62mTOR signaling pathway_Homo sapiens_hsa041500.88496855
63Oocyte meiosis_Homo sapiens_hsa041140.87037751
64Fatty acid metabolism_Homo sapiens_hsa012120.85552275
65RNA degradation_Homo sapiens_hsa030180.85060300
66Autoimmune thyroid disease_Homo sapiens_hsa053200.83645374
67Fatty acid elongation_Homo sapiens_hsa000620.82615402
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.81870335
69Tuberculosis_Homo sapiens_hsa051520.81407778
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80997575
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79247739
72Leishmaniasis_Homo sapiens_hsa051400.79105074
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78008940
74Herpes simplex infection_Homo sapiens_hsa051680.77909974
75Notch signaling pathway_Homo sapiens_hsa043300.77733795
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77577847
77Systemic lupus erythematosus_Homo sapiens_hsa053220.75867028
78N-Glycan biosynthesis_Homo sapiens_hsa005100.75665316
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.74202776
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.73802007
81Purine metabolism_Homo sapiens_hsa002300.73631214
82Epstein-Barr virus infection_Homo sapiens_hsa051690.72572111
83Type I diabetes mellitus_Homo sapiens_hsa049400.72255282
84Staphylococcus aureus infection_Homo sapiens_hsa051500.69613202
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69022404
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.67742821
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66522365
88Viral myocarditis_Homo sapiens_hsa054160.66069822
89Pentose phosphate pathway_Homo sapiens_hsa000300.62793066
90Regulation of autophagy_Homo sapiens_hsa041400.62700278
91Bladder cancer_Homo sapiens_hsa052190.61757149
92Sphingolipid metabolism_Homo sapiens_hsa006000.60823495
93Apoptosis_Homo sapiens_hsa042100.60686575
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58909392
95Hematopoietic cell lineage_Homo sapiens_hsa046400.58601833
96Galactose metabolism_Homo sapiens_hsa000520.58566943
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58425289
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58301511
99Metabolic pathways_Homo sapiens_hsa011000.57860240
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57142399
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56932151
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56639538
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54769280
104Shigellosis_Homo sapiens_hsa051310.54097201
105Peroxisome_Homo sapiens_hsa041460.53564808
106TNF signaling pathway_Homo sapiens_hsa046680.53174368
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53006198
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52979961
109Pertussis_Homo sapiens_hsa051330.52363385
110TGF-beta signaling pathway_Homo sapiens_hsa043500.51316369
111Alzheimers disease_Homo sapiens_hsa050100.51235291
112Primary bile acid biosynthesis_Homo sapiens_hsa001200.50431509
113Carbon metabolism_Homo sapiens_hsa012000.44560141
114Arachidonic acid metabolism_Homo sapiens_hsa005900.44008898
115Synaptic vesicle cycle_Homo sapiens_hsa047210.43565468
116Protein export_Homo sapiens_hsa030600.43274082
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42357499
118Wnt signaling pathway_Homo sapiens_hsa043100.41610793
119Influenza A_Homo sapiens_hsa051640.40452426
120Basal cell carcinoma_Homo sapiens_hsa052170.40307673
121Linoleic acid metabolism_Homo sapiens_hsa005910.38142036
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37805554
123Non-homologous end-joining_Homo sapiens_hsa034500.37741486
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34688131
125Adherens junction_Homo sapiens_hsa045200.34398974
126Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33613029
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.31889530
128Legionellosis_Homo sapiens_hsa051340.29906728
129Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27444784
130Primary immunodeficiency_Homo sapiens_hsa053400.27303882
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25477577
132Selenocompound metabolism_Homo sapiens_hsa004500.25276478
133Vitamin digestion and absorption_Homo sapiens_hsa049770.24826318
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23463640
135Arginine biosynthesis_Homo sapiens_hsa002200.23326394
136Tight junction_Homo sapiens_hsa045300.23292420
137Viral carcinogenesis_Homo sapiens_hsa052030.22421716
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21657744
139Pyruvate metabolism_Homo sapiens_hsa006200.20505469
140Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20010658
141alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19412261
142Glycosaminoglycan degradation_Homo sapiens_hsa005310.19031640
143Lysosome_Homo sapiens_hsa041420.17697558
144Cardiac muscle contraction_Homo sapiens_hsa042600.17218761
145Thyroid cancer_Homo sapiens_hsa052160.14258034
146VEGF signaling pathway_Homo sapiens_hsa043700.13969937
147Fat digestion and absorption_Homo sapiens_hsa049750.13751187

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