COMMD8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene binds coiled-coil domain-containing protein 22 (CCDC22), and this complex can regulate the turnover of I-kappa-B and the activation of NF-kappa-B. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)4.58634255
2respiratory electron transport chain (GO:0022904)4.31743109
3DNA deamination (GO:0045006)4.28788761
4electron transport chain (GO:0022900)4.24969119
5neutrophil activation involved in immune response (GO:0002283)4.12664282
6ribosomal small subunit assembly (GO:0000028)3.91464941
7respiratory chain complex IV assembly (GO:0008535)3.76803613
8protein neddylation (GO:0045116)3.67880001
9proteasome assembly (GO:0043248)3.63588061
10deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.62474648
11ribosomal small subunit biogenesis (GO:0042274)3.54616436
12cytochrome complex assembly (GO:0017004)3.46326423
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.42518350
14antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.41777104
15exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.38293031
16cytidine metabolic process (GO:0046087)3.28533916
17cytidine catabolic process (GO:0006216)3.28533916
18cytidine deamination (GO:0009972)3.28533916
19viral transcription (GO:0019083)3.25616953
20termination of RNA polymerase III transcription (GO:0006386)3.23910701
21transcription elongation from RNA polymerase III promoter (GO:0006385)3.23910701
22deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.23718611
23purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.21487143
242-deoxyribonucleotide biosynthetic process (GO:0009265)3.20359576
25deoxyribose phosphate biosynthetic process (GO:0046385)3.20359576
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.20057125
27sequestering of actin monomers (GO:0042989)3.18945999
28regulation of cellular amine metabolic process (GO:0033238)3.15985047
29protein targeting to mitochondrion (GO:0006626)3.14377654
30cotranslational protein targeting to membrane (GO:0006613)3.13745661
31deoxyribose phosphate catabolic process (GO:0046386)3.10700501
32oxidative phosphorylation (GO:0006119)3.09852167
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.08934408
34translational termination (GO:0006415)3.08343367
35energy coupled proton transport, down electrochemical gradient (GO:0015985)3.05838278
36ATP synthesis coupled proton transport (GO:0015986)3.05838278
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.05684759
38regulation of ubiquitin-protein transferase activity (GO:0051438)3.05280582
39mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.04480649
40protein targeting to ER (GO:0045047)3.03812446
41protein localization to mitochondrion (GO:0070585)3.01872231
42regulation of mitochondrial translation (GO:0070129)3.01776633
43DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.01181824
447-methylguanosine mRNA capping (GO:0006370)3.00906400
45positive regulation of cell cycle arrest (GO:0071158)3.00610361
46regulation of ligase activity (GO:0051340)3.00215374
477-methylguanosine RNA capping (GO:0009452)2.99787204
48RNA capping (GO:0036260)2.99787204
49deoxyribonucleotide catabolic process (GO:0009264)2.98639148
50purine nucleotide salvage (GO:0032261)2.97651708
51intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.95755150
52signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.95755150
53signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.95123166
54signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.95123166
55signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.95123166
56purine-containing compound salvage (GO:0043101)2.94038757
57negative regulation of ligase activity (GO:0051352)2.92273846
58negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.92273846
59establishment of protein localization to mitochondrion (GO:0072655)2.92047342
60rRNA modification (GO:0000154)2.91247609
61protein maturation by protein folding (GO:0022417)2.91131778
62maturation of SSU-rRNA (GO:0030490)2.90550972
63protein localization to endoplasmic reticulum (GO:0070972)2.90370599
64positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.90334857
65establishment of protein localization to endoplasmic reticulum (GO:0072599)2.89633957
66deoxyribonucleotide biosynthetic process (GO:0009263)2.89598772
67purine nucleoside triphosphate biosynthetic process (GO:0009145)2.89162446
68positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.87911438
69hydrogen ion transmembrane transport (GO:1902600)2.87861701
70deoxyribose phosphate metabolic process (GO:0019692)2.87177367
71negative regulation of protein ubiquitination (GO:0031397)2.87044974
72microglial cell activation (GO:0001774)2.86655295
73ATP biosynthetic process (GO:0006754)2.86169688
74inner mitochondrial membrane organization (GO:0007007)2.85525090
75CENP-A containing nucleosome assembly (GO:0034080)2.85287309
76pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.84521046
77regulation of B cell receptor signaling pathway (GO:0050855)2.84131256
78regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.83530738
79chaperone-mediated protein transport (GO:0072321)2.83192439
80positive regulation of protein homodimerization activity (GO:0090073)2.82688198
81signal peptide processing (GO:0006465)2.80506948
82signal transduction involved in cell cycle checkpoint (GO:0072395)2.80304420
83purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.78696798
84purine deoxyribonucleotide catabolic process (GO:0009155)2.78549742
85response to pheromone (GO:0019236)2.78382499
86histone mRNA metabolic process (GO:0008334)2.77847999
87antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.77130245
88signal transduction involved in DNA integrity checkpoint (GO:0072401)2.76935730
89signal transduction involved in DNA damage checkpoint (GO:0072422)2.76935730
90regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.76628748
91ribosomal large subunit biogenesis (GO:0042273)2.76370661
92pyrimidine ribonucleoside catabolic process (GO:0046133)2.74844082
93mitochondrial respiratory chain complex I assembly (GO:0032981)2.74723415
94NADH dehydrogenase complex assembly (GO:0010257)2.74723415
95mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.74723415
96regulation of cellular amino acid metabolic process (GO:0006521)2.72950750
97neutrophil activation (GO:0042119)2.70127078
98positive regulation of chemokine secretion (GO:0090197)2.69812369
99leukocyte aggregation (GO:0070486)2.69278556
100deoxyribonucleotide metabolic process (GO:0009262)2.69137560
101pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.68593741
102respiratory burst (GO:0045730)2.67739230
103protein K11-linked ubiquitination (GO:0070979)2.67730564
104positive regulation of antigen processing and presentation (GO:0002579)2.66518046
105proton transport (GO:0015992)2.66230300
106peptidyl-histidine modification (GO:0018202)2.66106787
107chromatin remodeling at centromere (GO:0031055)2.65848646
108negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.65007368
109negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.64978198
110negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.64177098
1112-deoxyribonucleotide metabolic process (GO:0009394)2.63961603
112cellular response to interferon-beta (GO:0035458)2.60291909
113mast cell activation (GO:0045576)2.58768570
114viral life cycle (GO:0019058)2.58584612
115protein complex biogenesis (GO:0070271)2.58482490
116establishment of viral latency (GO:0019043)2.56128228
117translational elongation (GO:0006414)2.55307361
118interferon-gamma production (GO:0032609)2.54102506
119mannosylation (GO:0097502)2.53512103
120platelet dense granule organization (GO:0060155)2.52762021
121DNA damage response, detection of DNA damage (GO:0042769)2.52740956
122positive regulation of monocyte chemotaxis (GO:0090026)2.52478722
123G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.49978029
124anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.49038963
125mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.45958155
126regulation of T cell migration (GO:2000404)2.44214874
127GPI anchor biosynthetic process (GO:0006506)2.42740240
128cellular protein complex disassembly (GO:0043624)2.42722391
129tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.42551619
130RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.42551619
131positive regulation of T cell migration (GO:2000406)2.41832624
132positive regulation of T-helper 1 type immune response (GO:0002827)2.41795541
133regulation of antigen processing and presentation (GO:0002577)2.40751823
134transcription elongation from RNA polymerase I promoter (GO:0006362)2.40693437
135positive regulation of gamma-delta T cell activation (GO:0046645)2.39949156
136granulocyte activation (GO:0036230)2.39055043
137nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.37443643
138positive regulation of interleukin-10 production (GO:0032733)2.37374737
139organelle disassembly (GO:1903008)2.37072167
140protein deneddylation (GO:0000338)2.36742916
141translation (GO:0006412)2.36114497
142cullin deneddylation (GO:0010388)2.35377769
143positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.35073490
144transcription-coupled nucleotide-excision repair (GO:0006283)2.34904712
145long-chain fatty acid biosynthetic process (GO:0042759)2.34776700
146GTP biosynthetic process (GO:0006183)2.32185136
147histamine secretion (GO:0001821)2.31605721
148DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.31603176
149positive regulation of ligase activity (GO:0051351)2.31263844
150mitochondrial respiratory chain complex assembly (GO:0033108)2.30026664
151lymphoid progenitor cell differentiation (GO:0002320)2.29496581
152oligosaccharide catabolic process (GO:0009313)2.29188671
153positive regulation of alpha-beta T cell proliferation (GO:0046641)2.28328454

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.40844292
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.03165645
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.81515958
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.73812038
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.39311882
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.37050565
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.22197470
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.16075319
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.15266622
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.13136080
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.89590850
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.77683001
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.77509053
14ELK1_19687146_ChIP-ChIP_HELA_Human2.63129818
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.59176094
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.56075135
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.52424733
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.52154212
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.46012648
20VDR_23849224_ChIP-Seq_CD4+_Human2.34889123
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.31577552
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.27316641
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.26027351
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14131853
25* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.14055744
26SRF_21415370_ChIP-Seq_HL-1_Mouse2.05788892
27HOXB4_20404135_ChIP-ChIP_EML_Mouse2.03082065
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.96794569
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.96367479
30MYC_18555785_ChIP-Seq_MESCs_Mouse1.91747209
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.86883987
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.77106051
33FOXP3_21729870_ChIP-Seq_TREG_Human1.72138726
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.71700105
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68211527
36* IRF8_27001747_Chip-Seq_BMDM_Mouse1.65479489
37SPI1_23547873_ChIP-Seq_NB4_Human1.65388754
38DCP1A_22483619_ChIP-Seq_HELA_Human1.60623376
39IRF1_19129219_ChIP-ChIP_H3396_Human1.60105214
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.59720690
41TAF15_26573619_Chip-Seq_HEK293_Human1.51386312
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.48499547
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.46413740
44ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46017155
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.42576697
46MYC_18358816_ChIP-ChIP_MESCs_Mouse1.42490110
47MYC_19030024_ChIP-ChIP_MESCs_Mouse1.41312827
48EWS_26573619_Chip-Seq_HEK293_Human1.41257018
49VDR_22108803_ChIP-Seq_LS180_Human1.41031481
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.38072171
51TTF2_22483619_ChIP-Seq_HELA_Human1.37992484
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36783069
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36433805
54* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34264454
55SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33256018
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31268034
57HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30251277
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30176563
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29883940
60ELK1_22589737_ChIP-Seq_MCF10A_Human1.29718199
61EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.26842780
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26732554
63FUS_26573619_Chip-Seq_HEK293_Human1.24941901
64NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24176185
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23150551
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21946421
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19209485
68ZNF274_21170338_ChIP-Seq_K562_Hela1.19039035
69CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.17253144
70POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16073637
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14918124
72XRN2_22483619_ChIP-Seq_HELA_Human1.11380208
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.10366170
74ER_23166858_ChIP-Seq_MCF-7_Human1.10299502
75* TFEB_21752829_ChIP-Seq_HELA_Human1.09830309
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08393289
77GBX2_23144817_ChIP-Seq_PC3_Human1.08223570
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07440946
79GATA3_26560356_Chip-Seq_TH2_Human1.05322497
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05260645
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05178674
82MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03726431
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02788374
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02575981
85TP53_22573176_ChIP-Seq_HFKS_Human1.02554827
86* GABP_19822575_ChIP-Seq_HepG2_Human1.01704024
87PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.00920278
88EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00602201
89* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99337651
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98995200
91FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98474096
92FOXA1_25329375_ChIP-Seq_VCAP_Human0.98474096
93MYC_18940864_ChIP-ChIP_HL60_Human0.98438333
94PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98416758
95STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.97179691
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96520352
97RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96313008
98P300_19829295_ChIP-Seq_ESCs_Human0.95937070
99CRX_20693478_ChIP-Seq_RETINA_Mouse0.94985085
100AR_20517297_ChIP-Seq_VCAP_Human0.94168289
101* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93802933
102MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93721975
103IGF1R_20145208_ChIP-Seq_DFB_Human0.93367263
104MYB_26560356_Chip-Seq_TH2_Human0.91986769
105* SOX2_19829295_ChIP-Seq_ESCs_Human0.91560428
106* NANOG_19829295_ChIP-Seq_ESCs_Human0.91560428
107MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91161687
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90654879
109FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90571104
110HTT_18923047_ChIP-ChIP_STHdh_Human0.90532041
111WT1_19549856_ChIP-ChIP_CCG9911_Human0.89377741
112GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87971146
113MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87280441
114MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.87198684
115RUNX_20019798_ChIP-Seq_JUKART_Human0.86952695
116FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.86744151
117BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86459856
118STAT3_18555785_Chip-Seq_ESCs_Mouse0.86414208
119FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.85989705
120E2F7_22180533_ChIP-Seq_HELA_Human0.85890117
121SUZ12_18555785_Chip-Seq_ESCs_Mouse0.85811003
122P53_22387025_ChIP-Seq_ESCs_Mouse0.85019008
123LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84925743
124EZH2_27294783_Chip-Seq_NPCs_Mouse0.84637864
125ELF5_23300383_ChIP-Seq_T47D_Human0.83983497
126IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.83227280
127NFE2_27457419_Chip-Seq_LIVER_Mouse0.82828652
128SALL4_22934838_ChIP-ChIP_CD34+_Human0.82413966
129ERG_20517297_ChIP-Seq_VCAP_Human0.80144739

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.39031917
2MP0001835_abnormal_antigen_presentation3.96100586
3MP0005671_abnormal_response_to3.23118392
4MP0002148_abnormal_hypersensitivity_rea2.87501915
5MP0009379_abnormal_foot_pigmentation2.75840944
6MP0003136_yellow_coat_color2.75636941
7MP0006082_CNS_inflammation2.72534328
8MP0009785_altered_susceptibility_to2.72375537
9MP0006036_abnormal_mitochondrial_physio2.66935097
10MP0005084_abnormal_gallbladder_morpholo2.61961746
11MP0001529_abnormal_vocalization2.59168739
12MP0005409_darkened_coat_color2.54435869
13MP0003880_abnormal_central_pattern2.46391746
14MP0005000_abnormal_immune_tolerance2.40553317
15MP0003763_abnormal_thymus_physiology2.38288656
16MP0004381_abnormal_hair_follicle2.36269384
17MP0000015_abnormal_ear_pigmentation2.14111097
18MP0003724_increased_susceptibility_to2.13099921
19MP0005025_abnormal_response_to2.11040167
20MP0002723_abnormal_immune_serum2.07235267
21MP0002419_abnormal_innate_immunity2.06907623
22MP0002452_abnormal_antigen_presenting2.06872740
23MP0002420_abnormal_adaptive_immunity2.06021660
24MP0001819_abnormal_immune_cell2.05594664
25MP0001800_abnormal_humoral_immune2.04711286
26MP0005387_immune_system_phenotype2.04072902
27MP0001790_abnormal_immune_system2.04072902
28MP0000372_irregular_coat_pigmentation1.99907739
29MP0001188_hyperpigmentation1.96849697
30MP0006072_abnormal_retinal_apoptosis1.92840286
31MP0003718_maternal_effect1.91641961
32MP0006035_abnormal_mitochondrial_morpho1.91269325
33MP0003950_abnormal_plasma_membrane1.90411399
34MP0009333_abnormal_splenocyte_physiolog1.89252035
35MP0002837_dystrophic_cardiac_calcinosis1.81979432
36MP0000685_abnormal_immune_system1.72552075
37MP0002277_abnormal_respiratory_mucosa1.71483398
38MP0002163_abnormal_gland_morphology1.66912627
39MP0010386_abnormal_urinary_bladder1.65934820
40MP0000920_abnormal_myelination1.65227642
41MP0005171_absent_coat_pigmentation1.63276506
42MP0001905_abnormal_dopamine_level1.62653633
43MP0003436_decreased_susceptibility_to1.62201094
44MP0002398_abnormal_bone_marrow1.56349547
45MP0002132_abnormal_respiratory_system1.53996698
46MP0005174_abnormal_tail_pigmentation1.53364263
47MP0008877_abnormal_DNA_methylation1.53063842
48MP0000716_abnormal_immune_system1.52631197
49MP0001764_abnormal_homeostasis1.51086688
50MP0003195_calcinosis1.49042961
51MP0000358_abnormal_cell_content/1.46590127
52MP0000569_abnormal_digit_pigmentation1.45197523
53MP0001853_heart_inflammation1.44689322
54MP0005075_abnormal_melanosome_morpholog1.41925501
55MP0005645_abnormal_hypothalamus_physiol1.40365699
56MP0002405_respiratory_system_inflammati1.38591905
57MP0004957_abnormal_blastocyst_morpholog1.36820690
58MP0002095_abnormal_skin_pigmentation1.33693667
59MP0002090_abnormal_vision1.30479328
60MP0002009_preneoplasia1.30389434
61MP0002006_tumorigenesis1.30360664
62MP0000689_abnormal_spleen_morphology1.30283123
63MP0005058_abnormal_lysosome_morphology1.27515374
64MP0006054_spinal_hemorrhage1.26428137
65MP0005253_abnormal_eye_physiology1.22710841
66MP0008058_abnormal_DNA_repair1.21200649
67MP0002429_abnormal_blood_cell1.20832315
68MP0002722_abnormal_immune_system1.20787866
69MP0002638_abnormal_pupillary_reflex1.19560978
70MP0008007_abnormal_cellular_replicative1.19487656
71MP0002166_altered_tumor_susceptibility1.18617660
72MP0005332_abnormal_amino_acid1.17955272
73MP0002396_abnormal_hematopoietic_system1.12495784
74MP0008875_abnormal_xenobiotic_pharmacok1.09869037
75MP0008057_abnormal_DNA_replication1.08715187
76MP0003693_abnormal_embryo_hatching1.08336818
77MP0001851_eye_inflammation1.08218225
78MP0006292_abnormal_olfactory_placode1.06039406
79MP0002876_abnormal_thyroid_physiology1.05329011
80MP0005379_endocrine/exocrine_gland_phen1.05277780
81MP0001845_abnormal_inflammatory_respons1.04555807
82MP0004147_increased_porphyrin_level1.04367730
83MP0003011_delayed_dark_adaptation1.00516509
84MP0003252_abnormal_bile_duct0.99580613
85MP0004142_abnormal_muscle_tone0.99409552
86MP0000703_abnormal_thymus_morphology0.97754581
87MP0005464_abnormal_platelet_physiology0.97585240
88MP0005310_abnormal_salivary_gland0.97504378
89MP0000465_gastrointestinal_hemorrhage0.96440358
90MP0002933_joint_inflammation0.95001052
91MP0003448_altered_tumor_morphology0.94710417
92MP0001542_abnormal_bone_strength0.94432501
93MP0004782_abnormal_surfactant_physiolog0.93623089
94MP0002938_white_spotting0.93374074
95MP0005389_reproductive_system_phenotype0.91451071
96MP0000343_altered_response_to0.89629855
97MP0009697_abnormal_copulation0.89616832
98MP0002160_abnormal_reproductive_system0.89175260
99MP0003186_abnormal_redox_activity0.87751681
100MP0003866_abnormal_defecation0.87345013
101MP0005408_hypopigmentation0.87289235
102MP0003786_premature_aging0.87015078
103MP0008260_abnormal_autophagy0.86105306
104MP0008872_abnormal_physiological_respon0.86097794
105MP0000681_abnormal_thyroid_gland0.85102594
106MP0009764_decreased_sensitivity_to0.84968856
107MP0002736_abnormal_nociception_after0.84380221
108MP0000371_diluted_coat_color0.80821489
109MP0000516_abnormal_urinary_system0.80343084
110MP0005367_renal/urinary_system_phenotyp0.80343084
111MP0003787_abnormal_imprinting0.79769830
112MP0002102_abnormal_ear_morphology0.79723982
113MP0004510_myositis0.78982274
114MP0009046_muscle_twitch0.78321346
115MP0008873_increased_physiological_sensi0.77929371
116MP0002693_abnormal_pancreas_physiology0.77704357
117MP0005636_abnormal_mineral_homeostasis0.76918123
118MP0001756_abnormal_urination0.76856034
119MP0003122_maternal_imprinting0.76674026
120MP0005410_abnormal_fertilization0.75941175
121MP0008469_abnormal_protein_level0.75837639
122MP0001984_abnormal_olfaction0.75092913
123MP0001986_abnormal_taste_sensitivity0.74694418
124MP0006276_abnormal_autonomic_nervous0.74610962
125MP0003828_pulmonary_edema0.74417127
126MP0003077_abnormal_cell_cycle0.73692050
127MP0001533_abnormal_skeleton_physiology0.73539891
128MP0003121_genomic_imprinting0.72037093
129MP0010094_abnormal_chromosome_stability0.71893253
130MP0004215_abnormal_myocardial_fiber0.70103017
131MP0002019_abnormal_tumor_incidence0.70066381
132MP0001119_abnormal_female_reproductive0.69967280
133MP0000858_altered_metastatic_potential0.69952726
134MP0005395_other_phenotype0.69595234
135MP0001929_abnormal_gametogenesis0.68944740
136MP0009763_increased_sensitivity_to0.68486071
137MP0003690_abnormal_glial_cell0.67625041
138MP0010155_abnormal_intestine_physiology0.66639293
139MP0001186_pigmentation_phenotype0.66212613
140MP0000778_abnormal_nervous_system0.65700365
141MP0004742_abnormal_vestibular_system0.65278525
142MP0008932_abnormal_embryonic_tissue0.65158518
143MP0001968_abnormal_touch/_nociception0.65138408
144MP0003183_abnormal_peptide_metabolism0.61829229
145MP0002751_abnormal_autonomic_nervous0.61232408

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)3.96380774
23-Methylglutaconic aciduria (HP:0003535)3.79890260
3Acute necrotizing encephalopathy (HP:0006965)3.62966260
4Cerebral edema (HP:0002181)3.50350060
5Aplastic anemia (HP:0001915)3.42998535
6Abnormality of cells of the erythroid lineage (HP:0012130)3.28599443
7Mitochondrial inheritance (HP:0001427)3.27289122
8Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.16924247
9Progressive macrocephaly (HP:0004481)3.15714044
10Abnormal number of erythroid precursors (HP:0012131)3.13661512
11Recurrent bacterial skin infections (HP:0005406)3.11717861
12Lactic acidosis (HP:0003128)3.11053331
13Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.03204460
14Abnormality of alanine metabolism (HP:0010916)3.03204460
15Hyperalaninemia (HP:0003348)3.03204460
16Increased hepatocellular lipid droplets (HP:0006565)3.01826067
17Abnormal mitochondria in muscle tissue (HP:0008316)2.99643480
18Optic neuritis (HP:0100653)2.99404997
19Retrobulbar optic neuritis (HP:0100654)2.99404997
20Elevated erythrocyte sedimentation rate (HP:0003565)2.99343604
21Parakeratosis (HP:0001036)2.98214811
22Renal Fanconi syndrome (HP:0001994)2.95408279
23Increased intramyocellular lipid droplets (HP:0012240)2.94211806
24Stomatitis (HP:0010280)2.91922629
25Increased CSF lactate (HP:0002490)2.76272677
26Hepatocellular necrosis (HP:0001404)2.75999584
27Increased IgM level (HP:0003496)2.75882605
28Myositis (HP:0100614)2.74108385
29Reticulocytopenia (HP:0001896)2.68094653
30Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.67553409
31Obstructive lung disease (HP:0006536)2.67163684
32Chronic obstructive pulmonary disease (HP:0006510)2.67163684
33Thyroiditis (HP:0100646)2.64736485
34Microvesicular hepatic steatosis (HP:0001414)2.60865124
35Exertional dyspnea (HP:0002875)2.59472011
36Birth length less than 3rd percentile (HP:0003561)2.59305176
37Abnormality of glycolysis (HP:0004366)2.58068638
38Increased serum pyruvate (HP:0003542)2.58068638
39Renal cortical cysts (HP:0000803)2.55858370
40Abnormality of macrophages (HP:0004311)2.55073564
41Methylmalonic acidemia (HP:0002912)2.54778445
42Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.52359524
43Decreased activity of mitochondrial respiratory chain (HP:0008972)2.52359524
44Patchy hypopigmentation of hair (HP:0011365)2.51273905
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.49234795
46IgG deficiency (HP:0004315)2.47464245
47Acute encephalopathy (HP:0006846)2.46136557
48Eczematoid dermatitis (HP:0000976)2.44747706
49Generalized aminoaciduria (HP:0002909)2.44466764
50Abnormal hair whorl (HP:0010721)2.42726869
51Autoimmune hemolytic anemia (HP:0001890)2.41282874
52Orchitis (HP:0100796)2.40099459
53Degeneration of anterior horn cells (HP:0002398)2.39589183
54Abnormality of the anterior horn cell (HP:0006802)2.39589183
55Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.38639214
56Abnormal protein glycosylation (HP:0012346)2.38639214
57Mediastinal lymphadenopathy (HP:0100721)2.38636336
58Increased muscle lipid content (HP:0009058)2.36775376
59Agnosia (HP:0010524)2.36630319
60Chronic mucocutaneous candidiasis (HP:0002728)2.36356626
61Recurrent cutaneous fungal infections (HP:0011370)2.36356626
62Vacuolated lymphocytes (HP:0001922)2.35295317
63Abnormality of methionine metabolism (HP:0010901)2.32992522
64Abnormality of T cell number (HP:0011839)2.31745808
65Severe combined immunodeficiency (HP:0004430)2.31706248
66IgM deficiency (HP:0002850)2.31527626
67Lipid accumulation in hepatocytes (HP:0006561)2.31325551
68Recurrent skin infections (HP:0001581)2.31271149
69Hypothermia (HP:0002045)2.28753817
70Type I transferrin isoform profile (HP:0003642)2.28584429
71Lethargy (HP:0001254)2.27187368
72Agammaglobulinemia (HP:0004432)2.27128081
73Hypoproteinemia (HP:0003075)2.23811244
74Glycosuria (HP:0003076)2.23599119
75Abnormality of urine glucose concentration (HP:0011016)2.23599119
76Abnormality of aspartate family amino acid metabolism (HP:0010899)2.23220076
77Increased neuronal autofluorescent lipopigment (HP:0002074)2.22979397
78Abnormality of eosinophils (HP:0001879)2.22052630
79Increased serum lactate (HP:0002151)2.21089640
80T lymphocytopenia (HP:0005403)2.18665199
81Macrocytic anemia (HP:0001972)2.18057160
82Abnormality of T cell physiology (HP:0011840)2.15333785
83Abnormality of midbrain morphology (HP:0002418)2.14250756
84Molar tooth sign on MRI (HP:0002419)2.14250756
85CNS demyelination (HP:0007305)2.13393732
86Abnormality of the prostate (HP:0008775)2.13303027
87Recurrent pneumonia (HP:0006532)2.12794787
88Hepatosplenomegaly (HP:0001433)2.11495289
89Abnormality of the axillary hair (HP:0100134)2.11398238
90Abnormality of secondary sexual hair (HP:0009888)2.11398238
91Methylmalonic aciduria (HP:0012120)2.06931903
92Hepatic necrosis (HP:0002605)2.05735482
93White forelock (HP:0002211)2.05454764
94Aplasia/Hypoplasia of the sacrum (HP:0008517)2.03545460
95Palpitations (HP:0001962)2.00114383
96Chronic diarrhea (HP:0002028)1.97421813
97Pallor (HP:0000980)1.97097274
98Meningitis (HP:0001287)1.96676651
99Prostate neoplasm (HP:0100787)1.96135904
100Medial flaring of the eyebrow (HP:0010747)1.95860054
101Encephalitis (HP:0002383)1.94568695
102Constricted visual fields (HP:0001133)1.93904191
103Poor head control (HP:0002421)1.93762921
104Respiratory failure (HP:0002878)1.93599934
105Pancreatic cysts (HP:0001737)1.93145198
106Chronic otitis media (HP:0000389)1.92232854
107Abnormality of serum amino acid levels (HP:0003112)1.91818901
108Leukodystrophy (HP:0002415)1.91774987
109Respiratory difficulties (HP:0002880)1.91573048
110Pancytopenia (HP:0001876)1.91171219
111Optic disc pallor (HP:0000543)1.91104825
112Abnormality of renal resorption (HP:0011038)1.90779706
113Aplasia/hypoplasia of the uterus (HP:0008684)1.90412929
114Exercise intolerance (HP:0003546)1.90393354
115Anhidrosis (HP:0000970)1.90141632
116Congenital ichthyosiform erythroderma (HP:0007431)1.90102246
117B lymphocytopenia (HP:0010976)1.89987636
118Basal ganglia calcification (HP:0002135)1.89825658
119Type 2 muscle fiber atrophy (HP:0003554)1.87898891
120Abnormality of vitamin B metabolism (HP:0004340)1.87326195
121Recurrent bronchitis (HP:0002837)1.86014506
122Keratoconjunctivitis sicca (HP:0001097)1.85225153
123Eosinophilia (HP:0001880)1.85062577
124Heterochromia iridis (HP:0001100)1.84240432
125X-linked dominant inheritance (HP:0001423)1.84101340
126Abnormality of T cells (HP:0002843)1.83512828
127Vasculitis (HP:0002633)1.83194051
128Abnormality of the renal cortex (HP:0011035)1.83078124
129Median cleft lip (HP:0000161)1.82167769
130Leukocytosis (HP:0001974)1.81838459
131Abnormality of B cell number (HP:0010975)1.81788068
132Abnormal delayed hypersensitivity skin test (HP:0002963)1.81590912
133Abnormality of placental membranes (HP:0011409)1.80662615
134Amniotic constriction ring (HP:0009775)1.80662615
135Panhypogammaglobulinemia (HP:0003139)1.80184262
136Neutropenia (HP:0001875)1.79920344
137Nausea (HP:0002018)1.79849050
138Oral leukoplakia (HP:0002745)1.79137252
139Combined immunodeficiency (HP:0005387)1.78901803
140Nephrogenic diabetes insipidus (HP:0009806)1.76726849
141Dicarboxylic aciduria (HP:0003215)1.75279379
142Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75279379
143Recurrent fungal infections (HP:0002841)1.75125376
144Pancreatic fibrosis (HP:0100732)1.74387968
145Abnormality of the vitamin B12 metabolism (HP:0004341)1.74360518
146Keratoconjunctivitis (HP:0001096)1.74079197
147Microretrognathia (HP:0000308)1.74005655
148Atrophy/Degeneration involving motor neurons (HP:0007373)1.73188696
149Posterior subcapsular cataract (HP:0007787)1.72826440
150Prolonged neonatal jaundice (HP:0006579)1.72350060
151Congenital, generalized hypertrichosis (HP:0004540)1.71942499
152Testicular atrophy (HP:0000029)1.70970340
153Autoimmune thrombocytopenia (HP:0001973)1.70487661
154Reduced antithrombin III activity (HP:0001976)1.68063897
155Sparse eyelashes (HP:0000653)1.67651108
156Hypoplasia of the uterus (HP:0000013)1.67635626
157Hypoplasia of the fovea (HP:0007750)1.66818677
158Aplasia/Hypoplasia of the fovea (HP:0008060)1.66818677
159Abnormal protein N-linked glycosylation (HP:0012347)1.66566265
160Abnormal glycosylation (HP:0012345)1.66566265
161Decreased electroretinogram (ERG) amplitude (HP:0000654)1.66093359
162Dyschromatopsia (HP:0007641)1.64591273

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK2.96183964
2VRK12.81375232
3TXK2.80606959
4IRAK42.56193617
5TRIM282.54057645
6MAP3K122.41196585
7MST42.38510636
8STK162.31223685
9NEK12.25161706
10EIF2AK32.23457077
11VRK22.16424339
12BCR2.11060827
13PBK2.09118405
14EIF2AK12.03830663
15ADRBK21.95473848
16BLK1.95054853
17BMPR1B1.94168123
18NME21.88650062
19SCYL21.87388077
20MAP3K141.85905999
21MAP4K21.81290962
22BUB11.78119732
23TNIK1.67836120
24SIK31.62377253
25ACVR1B1.53972051
26TEC1.49280616
27GRK71.46305809
28KIT1.44490281
29TLK11.44168576
30BCKDK1.39584861
31IKBKE1.37113501
32BMPR21.33331449
33MAP4K11.31332111
34ZAK1.30743329
35SRPK11.29692581
36IRAK31.24428214
37GRK11.23669046
38CLK11.23137481
39YES11.16826833
40NUAK11.14538592
41NEK91.13744902
42TAOK31.12902763
43BRSK21.12845524
44IKBKB1.11799463
45MKNK11.10477762
46ITK1.08359576
47LYN1.08155170
48SYK1.07732364
49ERBB31.05586186
50ZAP701.04895511
51PDK21.04622793
52EIF2AK21.04428696
53TYK21.03802658
54OXSR11.03129373
55LCK1.01454876
56PLK30.99210006
57TGFBR20.97990362
58TESK20.97001254
59PLK20.96350421
60RIPK40.94776168
61DYRK20.90917129
62BTK0.89005789
63TBK10.88687517
64TESK10.86079640
65DAPK10.85181798
66MAPKAPK50.84459667
67CSNK1G30.83282451
68WNK30.82559771
69PKN10.80929045
70IRAK20.80812261
71MAP2K70.79733535
72FLT30.79652798
73TGFBR10.79286739
74RPS6KA40.78784844
75NME10.78380671
76KDR0.77967289
77LIMK10.75818665
78FGR0.75507266
79STK240.75458626
80PAK40.74830693
81PIM20.74794120
82CDK190.74163413
83TSSK60.74046627
84CDK30.73051410
85PLK10.71671626
86RPS6KA50.71404401
87FES0.70158083
88STK30.69924967
89ILK0.69616773
90MAPK130.69504745
91CSF1R0.69178547
92STK390.68043175
93EPHA30.65080334
94NEK60.63865028
95STK100.63692716
96PRPF4B0.63590081
97TRPM70.62018205
98CDK80.60189462
99MYLK0.57852467
100WEE10.56659031
101AURKB0.56471579
102CSNK1G10.55697482
103FGFR20.55463909
104JAK30.54923886
105CSNK1A1L0.54354045
106ABL20.54134978
107PNCK0.52622936
108PRKCQ0.52447309
109EPHA40.52249282
110TTK0.51935174
111PIK3CG0.50757457
112PLK40.50354418
113STK38L0.49787578
114STK40.49217654
115HCK0.48952028
116CSNK2A20.48762584
117ARAF0.48708052
118ADRBK10.47874392
119PRKCD0.46078613
120DAPK30.45999299
121CCNB10.45613034
122PINK10.44475556
123PAK30.44179618
124MAP3K50.43764742
125MUSK0.43577917
126CAMKK20.43577022
127PASK0.41588868
128CSNK2A10.41054533
129CSNK1G20.40985376
130ERBB40.40756887
131INSRR0.39573055
132UHMK10.39045304
133CSK0.38950025
134FRK0.38586416
135GRK50.38073084
136ABL10.37322534
137PRKCE0.37290502

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.83940834
2Ribosome_Homo sapiens_hsa030103.43926919
3Protein export_Homo sapiens_hsa030602.81909027
4RNA polymerase_Homo sapiens_hsa030202.73593352
5Oxidative phosphorylation_Homo sapiens_hsa001902.68301847
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.34412698
7Parkinsons disease_Homo sapiens_hsa050122.23858062
8Primary immunodeficiency_Homo sapiens_hsa053402.07643838
9Graft-versus-host disease_Homo sapiens_hsa053322.01671577
10Allograft rejection_Homo sapiens_hsa053301.88717837
11Nucleotide excision repair_Homo sapiens_hsa034201.73301264
12Mismatch repair_Homo sapiens_hsa034301.68621866
13Spliceosome_Homo sapiens_hsa030401.68351311
14Alzheimers disease_Homo sapiens_hsa050101.66487787
15DNA replication_Homo sapiens_hsa030301.62916720
16Sulfur metabolism_Homo sapiens_hsa009201.62828964
17Huntingtons disease_Homo sapiens_hsa050161.57058365
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.55962233
19Basal transcription factors_Homo sapiens_hsa030221.54635799
20Rheumatoid arthritis_Homo sapiens_hsa053231.51914283
21Autoimmune thyroid disease_Homo sapiens_hsa053201.51382722
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.50060156
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.45376391
24Antigen processing and presentation_Homo sapiens_hsa046121.39771822
25Homologous recombination_Homo sapiens_hsa034401.39544966
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37744685
27Pyrimidine metabolism_Homo sapiens_hsa002401.37515146
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.36073373
29Propanoate metabolism_Homo sapiens_hsa006401.32317305
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32014358
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.31152315
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.30413346
33Measles_Homo sapiens_hsa051621.27744402
34Hematopoietic cell lineage_Homo sapiens_hsa046401.27499214
35Asthma_Homo sapiens_hsa053101.25657679
36Collecting duct acid secretion_Homo sapiens_hsa049661.21633211
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.19037936
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.18215019
39Leishmaniasis_Homo sapiens_hsa051401.17946443
40Non-homologous end-joining_Homo sapiens_hsa034501.16946327
41Other glycan degradation_Homo sapiens_hsa005111.16102144
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15167009
43Pertussis_Homo sapiens_hsa051331.12251967
44Folate biosynthesis_Homo sapiens_hsa007901.10224926
45Phagosome_Homo sapiens_hsa041451.09462021
46Base excision repair_Homo sapiens_hsa034101.07506830
47Epstein-Barr virus infection_Homo sapiens_hsa051691.06287840
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.05783564
49Legionellosis_Homo sapiens_hsa051341.05744525
50RNA degradation_Homo sapiens_hsa030181.00160469
51Shigellosis_Homo sapiens_hsa051310.98978230
52Malaria_Homo sapiens_hsa051440.97240887
53Sphingolipid metabolism_Homo sapiens_hsa006000.93656026
54Glutathione metabolism_Homo sapiens_hsa004800.92195236
55T cell receptor signaling pathway_Homo sapiens_hsa046600.91067713
56Type I diabetes mellitus_Homo sapiens_hsa049400.90818106
57Herpes simplex infection_Homo sapiens_hsa051680.90603012
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.89942988
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89844514
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89547590
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88439536
62Vibrio cholerae infection_Homo sapiens_hsa051100.88285451
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87947944
64Tuberculosis_Homo sapiens_hsa051520.84791503
65Lysosome_Homo sapiens_hsa041420.84392373
66Fanconi anemia pathway_Homo sapiens_hsa034600.84284577
67Ether lipid metabolism_Homo sapiens_hsa005650.82697755
68One carbon pool by folate_Homo sapiens_hsa006700.82617890
69Salmonella infection_Homo sapiens_hsa051320.78959234
70Osteoclast differentiation_Homo sapiens_hsa043800.78562914
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77221996
72Pyruvate metabolism_Homo sapiens_hsa006200.77117323
73Fatty acid elongation_Homo sapiens_hsa000620.75833788
74Purine metabolism_Homo sapiens_hsa002300.74721407
75Nitrogen metabolism_Homo sapiens_hsa009100.72935504
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71639158
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70772902
78RNA transport_Homo sapiens_hsa030130.70632459
79B cell receptor signaling pathway_Homo sapiens_hsa046620.70230989
80Peroxisome_Homo sapiens_hsa041460.70111538
81Arachidonic acid metabolism_Homo sapiens_hsa005900.69391448
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69082325
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68943974
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.67664439
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67329269
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65735188
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65019842
88Chemokine signaling pathway_Homo sapiens_hsa040620.64216013
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.63708877
90Metabolic pathways_Homo sapiens_hsa011000.63619275
91Viral myocarditis_Homo sapiens_hsa054160.62689119
92Steroid biosynthesis_Homo sapiens_hsa001000.62510239
93Serotonergic synapse_Homo sapiens_hsa047260.59483150
94Systemic lupus erythematosus_Homo sapiens_hsa053220.59434150
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59104201
96Regulation of autophagy_Homo sapiens_hsa041400.58412394
97p53 signaling pathway_Homo sapiens_hsa041150.58061649
98Cell cycle_Homo sapiens_hsa041100.57968654
99Influenza A_Homo sapiens_hsa051640.57822911
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.55024962
101Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54884826
102Apoptosis_Homo sapiens_hsa042100.53749521
103Phototransduction_Homo sapiens_hsa047440.51974326
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51865873
105African trypanosomiasis_Homo sapiens_hsa051430.49760524
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48125855
107N-Glycan biosynthesis_Homo sapiens_hsa005100.46820905
108Jak-STAT signaling pathway_Homo sapiens_hsa046300.43129281
109Hepatitis B_Homo sapiens_hsa051610.41735725
110Selenocompound metabolism_Homo sapiens_hsa004500.41701214
111Alcoholism_Homo sapiens_hsa050340.39712158
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.38333120
113Carbon metabolism_Homo sapiens_hsa012000.37296877
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36511275
115Staphylococcus aureus infection_Homo sapiens_hsa051500.36056783
116Glycosaminoglycan degradation_Homo sapiens_hsa005310.35650606
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35499819
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35259241
119TNF signaling pathway_Homo sapiens_hsa046680.35102124
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34879410
121Viral carcinogenesis_Homo sapiens_hsa052030.34643574
122Toxoplasmosis_Homo sapiens_hsa051450.34292911
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33014133
124Chemical carcinogenesis_Homo sapiens_hsa052040.32630129
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31941223
126Cardiac muscle contraction_Homo sapiens_hsa042600.30632585
127Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30271078
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.29843218
129Butanoate metabolism_Homo sapiens_hsa006500.29090755
130HTLV-I infection_Homo sapiens_hsa051660.28213500
131Caffeine metabolism_Homo sapiens_hsa002320.26181342
132Tryptophan metabolism_Homo sapiens_hsa003800.24965900
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24190882
134Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23583481
135Oocyte meiosis_Homo sapiens_hsa041140.23318454
136Pentose phosphate pathway_Homo sapiens_hsa000300.22644368
137Primary bile acid biosynthesis_Homo sapiens_hsa001200.22011501

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