COMMD9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1energy coupled proton transport, down electrochemical gradient (GO:0015985)6.43339370
2ATP synthesis coupled proton transport (GO:0015986)6.43339370
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.36504205
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.02955851
5fatty acid elongation (GO:0030497)5.88767555
6axon ensheathment in central nervous system (GO:0032291)5.78023627
7central nervous system myelination (GO:0022010)5.78023627
8protein neddylation (GO:0045116)5.21302006
9respiratory electron transport chain (GO:0022904)5.18812495
10electron transport chain (GO:0022900)5.05084606
11cholesterol biosynthetic process (GO:0006695)4.78053726
12chaperone-mediated protein transport (GO:0072321)4.76693971
13proteasome assembly (GO:0043248)4.53400379
14protein complex biogenesis (GO:0070271)4.28291282
15sterol biosynthetic process (GO:0016126)4.16231358
16nucleotide transmembrane transport (GO:1901679)4.04380944
17mitochondrial respiratory chain complex I assembly (GO:0032981)4.00380649
18NADH dehydrogenase complex assembly (GO:0010257)4.00380649
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.00380649
20cullin deneddylation (GO:0010388)3.99805435
21signal peptide processing (GO:0006465)3.91487710
22long-chain fatty acid biosynthetic process (GO:0042759)3.86969322
23water-soluble vitamin biosynthetic process (GO:0042364)3.84207900
24platelet dense granule organization (GO:0060155)3.83174182
25mitochondrial respiratory chain complex assembly (GO:0033108)3.81151837
26purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.76751995
27rRNA modification (GO:0000154)3.73378737
28substantia nigra development (GO:0021762)3.72134316
29DNA deamination (GO:0045006)3.69268508
30L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.67701389
31aldehyde catabolic process (GO:0046185)3.67585765
32ATP hydrolysis coupled proton transport (GO:0015991)3.67106702
33energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.67106702
34protein deneddylation (GO:0000338)3.57327791
35hydrogen ion transmembrane transport (GO:1902600)3.56474742
36isoprenoid biosynthetic process (GO:0008299)3.54359075
37transcription elongation from RNA polymerase III promoter (GO:0006385)3.54114463
38termination of RNA polymerase III transcription (GO:0006386)3.54114463
39response to redox state (GO:0051775)3.47540650
40regulation of cellular amino acid metabolic process (GO:0006521)3.41411570
41establishment of protein localization to mitochondrial membrane (GO:0090151)3.37911338
42negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.33505145
43ubiquinone biosynthetic process (GO:0006744)3.33066727
44proton transport (GO:0015992)3.30924559
45positive regulation of mitochondrial fission (GO:0090141)3.30487362
46ensheathment of neurons (GO:0007272)3.30210054
47axon ensheathment (GO:0008366)3.30210054
48amyloid precursor protein metabolic process (GO:0042982)3.28931270
49ATP biosynthetic process (GO:0006754)3.26233691
50myelination (GO:0042552)3.25903189
51mannosylation (GO:0097502)3.24836879
52hydrogen transport (GO:0006818)3.23021489
53cellular copper ion homeostasis (GO:0006878)3.22700745
54peptidyl-histidine modification (GO:0018202)3.22095587
55protein-cofactor linkage (GO:0018065)3.21071351
56deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.18236636
57purine deoxyribonucleotide metabolic process (GO:0009151)3.17728002
58pyrimidine-containing compound transmembrane transport (GO:0072531)3.17466138
59purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.16364281
60respiratory chain complex IV assembly (GO:0008535)3.16335622
61purine nucleoside triphosphate biosynthetic process (GO:0009145)3.16022158
62negative regulation of ligase activity (GO:0051352)3.13991482
63negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.13991482
64regulation of mitochondrial translation (GO:0070129)3.10786798
65GPI anchor biosynthetic process (GO:0006506)3.10190255
66antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.09458800
67protein targeting to mitochondrion (GO:0006626)3.09257260
68intracellular protein transmembrane import (GO:0044743)3.08872560
69amino acid salvage (GO:0043102)3.07273682
70L-methionine salvage (GO:0071267)3.07273682
71L-methionine biosynthetic process (GO:0071265)3.07273682
72DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.05604780
73tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.03900384
74RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.03900384
75long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.03804592
76purine nucleotide salvage (GO:0032261)3.03358841
77regulation of collateral sprouting (GO:0048670)3.02683298
78nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.99691678
79intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.97678708
80signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.97678708
81establishment of protein localization to mitochondrion (GO:0072655)2.96841268
82copper ion homeostasis (GO:0055070)2.94935552
837-methylguanosine mRNA capping (GO:0006370)2.94846181
84signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.94340819
85signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.94340819
86signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.94340819
87regulation of cellular amine metabolic process (GO:0033238)2.94023183
88rRNA methylation (GO:0031167)2.93857165
89ER overload response (GO:0006983)2.91723208
90ubiquinone metabolic process (GO:0006743)2.91065618
91positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.90742925
92purine deoxyribonucleotide catabolic process (GO:0009155)2.89591954
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.89511055
94RNA capping (GO:0036260)2.87864032
957-methylguanosine RNA capping (GO:0009452)2.87864032
96negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.87425801
97antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.86733384
98long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.86407420
99signal transduction involved in DNA damage checkpoint (GO:0072422)2.86166890
100signal transduction involved in DNA integrity checkpoint (GO:0072401)2.86166890
101deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.86057017
102C-terminal protein lipidation (GO:0006501)2.85789309
103GPI anchor metabolic process (GO:0006505)2.84419976
104iron-sulfur cluster assembly (GO:0016226)2.84349525
105metallo-sulfur cluster assembly (GO:0031163)2.84349525
106cytochrome complex assembly (GO:0017004)2.83222079
107transferrin transport (GO:0033572)2.83159308
108signal transduction involved in cell cycle checkpoint (GO:0072395)2.82382489
109branched-chain amino acid catabolic process (GO:0009083)2.82256330
110GTP biosynthetic process (GO:0006183)2.81821344
111glycerophospholipid catabolic process (GO:0046475)2.80825961
112preassembly of GPI anchor in ER membrane (GO:0016254)2.80599910
113establishment of mitochondrion localization (GO:0051654)2.80144352
114base-excision repair, AP site formation (GO:0006285)2.79607042
115anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.79028299
116amyloid precursor protein catabolic process (GO:0042987)2.76912864
117adenosine metabolic process (GO:0046085)2.76404441
118ribonucleoside triphosphate biosynthetic process (GO:0009201)2.76318221
119fatty-acyl-CoA metabolic process (GO:0035337)2.75394962
120positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.74083618
121nucleotide transport (GO:0006862)2.73958298
122deoxyribonucleotide catabolic process (GO:0009264)2.73845031
123purine-containing compound salvage (GO:0043101)2.71371440
124fatty-acyl-CoA biosynthetic process (GO:0046949)2.68896690
125inner mitochondrial membrane organization (GO:0007007)2.68097468
126peroxisome fission (GO:0016559)2.67683055
127mitochondrial transport (GO:0006839)2.67630989
128regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.67215523
129mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.66243280
130quinone metabolic process (GO:1901661)2.66144754
131protein localization to mitochondrion (GO:0070585)2.65380170
132deoxyribose phosphate catabolic process (GO:0046386)2.63245375
133sequestering of actin monomers (GO:0042989)2.63241172
134oxidative phosphorylation (GO:0006119)2.62653947
135pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.61627656
136positive regulation of ligase activity (GO:0051351)2.60209800
137C-terminal protein amino acid modification (GO:0018410)2.57160121
138quinone biosynthetic process (GO:1901663)2.54179776
1392-deoxyribonucleotide metabolic process (GO:0009394)2.52171748
140tRNA processing (GO:0008033)2.49990465
141phagosome maturation (GO:0090382)2.46796690
142behavioral response to nicotine (GO:0035095)2.46796503

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.59661794
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.47977498
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.39569305
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.33692016
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.94563484
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.78023696
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.63340159
8PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.60476311
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.51656255
10* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.13005130
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.99990681
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.99939272
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.94882582
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.82279786
15ZNF274_21170338_ChIP-Seq_K562_Hela2.78641179
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.50413839
17* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.36901721
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16139948
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07624303
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.98042574
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.96765821
22YY1_21170310_ChIP-Seq_MESCs_Mouse1.86682264
23IRF8_21731497_ChIP-ChIP_J774_Mouse1.84450688
24BP1_19119308_ChIP-ChIP_Hs578T_Human1.83904410
25MYC_18358816_ChIP-ChIP_MESCs_Mouse1.73605757
26DCP1A_22483619_ChIP-Seq_HELA_Human1.73375218
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71066327
28CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.68776848
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67590715
30VDR_23849224_ChIP-Seq_CD4+_Human1.67100871
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65331356
32TP53_22573176_ChIP-Seq_HFKS_Human1.64580076
33CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.63634490
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58863603
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56861817
36MYC_18940864_ChIP-ChIP_HL60_Human1.56075023
37GBX2_23144817_ChIP-Seq_PC3_Human1.53882206
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53427751
39VDR_22108803_ChIP-Seq_LS180_Human1.47833403
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.46913069
41ELK1_19687146_ChIP-ChIP_HELA_Human1.46218111
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45866595
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43775918
44* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42863801
45GABP_19822575_ChIP-Seq_HepG2_Human1.39486014
46TAF15_26573619_Chip-Seq_HEK293_Human1.37328340
47ELK1_22589737_ChIP-Seq_MCF10A_Human1.36424075
48CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.35193080
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34924529
50FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.33046350
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32914067
52FOXP3_21729870_ChIP-Seq_TREG_Human1.31736266
53* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31533892
54SOX17_20123909_ChIP-Seq_XEN_Mouse1.28538333
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28314314
56MYC_18555785_ChIP-Seq_MESCs_Mouse1.28241345
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.23537815
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21694091
59BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20596368
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.19465958
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18756592
62EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.18390913
63ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18355746
64EOMES_21245162_ChIP-Seq_HESCs_Human1.14337601
65PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12222945
66PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11766888
67XRN2_22483619_ChIP-Seq_HELA_Human1.11285757
68MYC_19030024_ChIP-ChIP_MESCs_Mouse1.11220047
69PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.09980427
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09767997
71* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09657477
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09187437
73P300_19829295_ChIP-Seq_ESCs_Human1.08805434
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08121874
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05334973
76ER_23166858_ChIP-Seq_MCF-7_Human1.05133295
77EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04975446
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04837600
79* SPI1_23547873_ChIP-Seq_NB4_Human1.03858393
80EWS_26573619_Chip-Seq_HEK293_Human1.03550976
81* AR_20517297_ChIP-Seq_VCAP_Human1.02789364
82* TFEB_21752829_ChIP-Seq_HELA_Human1.02131913
83SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00956044
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00502193
85FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00164473
86FOXA1_25329375_ChIP-Seq_VCAP_Human1.00164473
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98719862
88NCOR_22424771_ChIP-Seq_293T_Human0.96550056
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95747091
90REST_19997604_ChIP-ChIP_NEURONS_Mouse0.95019391
91TTF2_22483619_ChIP-Seq_HELA_Human0.93324186
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92681252
93CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92190570
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91362882
95* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90898458
96GATA3_26560356_Chip-Seq_TH2_Human0.90598020
97CTCF_18555785_ChIP-Seq_MESCs_Mouse0.90141953
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89927934
99NELFA_20434984_ChIP-Seq_ESCs_Mouse0.89194205
100CIITA_25753668_ChIP-Seq_RAJI_Human0.88040482
101KDM5A_27292631_Chip-Seq_BREAST_Human0.87911463
102SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87361461
103SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.87176029
104POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.86775851
105IRF1_19129219_ChIP-ChIP_H3396_Human0.85018143
106HTT_18923047_ChIP-ChIP_STHdh_Human0.84761144
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84723660
108CBX2_27304074_Chip-Seq_ESCs_Mouse0.84123903
109FOXA1_21572438_ChIP-Seq_LNCaP_Human0.83549312
110RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.83546399
111GATA3_21878914_ChIP-Seq_MCF-7_Human0.82913001
112YY1_22570637_ChIP-Seq_MALME-3M_Human0.82198218
113STAT1_20625510_ChIP-Seq_HELA_Human0.81084185
114FUS_26573619_Chip-Seq_HEK293_Human0.80896605
115PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79436607
116SOX2_19829295_ChIP-Seq_ESCs_Human0.78945614
117NANOG_19829295_ChIP-Seq_ESCs_Human0.78945614
118ERG_20887958_ChIP-Seq_HPC-7_Mouse0.78608084
119PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78170009
120* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77565174
121POU3F2_20337985_ChIP-ChIP_501MEL_Human0.76780658
122CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76647057
123HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.76445037
124ETV2_25802403_ChIP-Seq_MESCs_Mouse0.76422422
125CTBP1_25329375_ChIP-Seq_LNCAP_Human0.75144142
126IGF1R_20145208_ChIP-Seq_DFB_Human0.74324314
127EZH2_27304074_Chip-Seq_ESCs_Mouse0.73105537
128CTCF_20526341_ChIP-Seq_ESCs_Human0.73065185
129* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.72114152
130PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.71091934
131* NANOG_20526341_ChIP-Seq_ESCs_Human0.69609190
132PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.69496322
133KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.68974904
134PADI4_21655091_ChIP-ChIP_MCF-7_Human0.67306182
135TBX5_21415370_ChIP-Seq_HL-1_Mouse0.67223148
136CTBP2_25329375_ChIP-Seq_LNCAP_Human0.67030521
137REST_18959480_ChIP-ChIP_MESCs_Mouse0.66988280
138PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.66037877

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.79463128
2MP0001529_abnormal_vocalization3.66985178
3MP0000920_abnormal_myelination3.13561716
4MP0003880_abnormal_central_pattern3.04590298
5MP0001905_abnormal_dopamine_level2.99694768
6MP0003195_calcinosis2.38939330
7MP0004043_abnormal_pH_regulation2.36616895
8MP0003329_amyloid_beta_deposits2.31640862
9MP0005084_abnormal_gallbladder_morpholo2.20922829
10MP0000372_irregular_coat_pigmentation2.12250267
11MP0006276_abnormal_autonomic_nervous2.12144344
12MP0008058_abnormal_DNA_repair2.10316867
13MP0004142_abnormal_muscle_tone2.09366808
14MP0008877_abnormal_DNA_methylation1.99931476
15MP0006036_abnormal_mitochondrial_physio1.99899837
16MP0004270_analgesia1.99575846
17MP0005171_absent_coat_pigmentation1.95010103
18MP0004742_abnormal_vestibular_system1.90717399
19MP0005408_hypopigmentation1.89948086
20MP0000566_synostosis1.83133064
21MP0002148_abnormal_hypersensitivity_rea1.80008379
22MP0002163_abnormal_gland_morphology1.77520770
23MP0002272_abnormal_nervous_system1.76189797
24MP0002734_abnormal_mechanical_nocicepti1.76072724
25MP0005058_abnormal_lysosome_morphology1.75499372
26MP0003186_abnormal_redox_activity1.73125005
27MP0010386_abnormal_urinary_bladder1.71909449
28MP0002822_catalepsy1.71217590
29MP0005379_endocrine/exocrine_gland_phen1.70373862
30MP0002736_abnormal_nociception_after1.67552349
31MP0003136_yellow_coat_color1.66752763
32MP0009764_decreased_sensitivity_to1.65931134
33MP0003634_abnormal_glial_cell1.65156690
34MP0002064_seizures1.63895463
35MP0002735_abnormal_chemical_nociception1.63581426
36MP0004147_increased_porphyrin_level1.60528192
37MP0001727_abnormal_embryo_implantation1.58789632
38MP0006082_CNS_inflammation1.58534441
39MP0008260_abnormal_autophagy1.58411605
40MP0005085_abnormal_gallbladder_physiolo1.53990009
41MP0005075_abnormal_melanosome_morpholog1.52683528
42MP0006035_abnormal_mitochondrial_morpho1.50854292
43MP0002229_neurodegeneration1.50171667
44MP0001986_abnormal_taste_sensitivity1.49061898
45MP0009785_altered_susceptibility_to1.46331295
46MP0001835_abnormal_antigen_presentation1.44563226
47MP0009046_muscle_twitch1.44478915
48MP0001970_abnormal_pain_threshold1.43213218
49MP0002837_dystrophic_cardiac_calcinosis1.42792622
50MP0009379_abnormal_foot_pigmentation1.42168269
51MP0000015_abnormal_ear_pigmentation1.39580416
52MP0002733_abnormal_thermal_nociception1.38840107
53MP0002139_abnormal_hepatobiliary_system1.36925028
54MP0005671_abnormal_response_to1.36805402
55MP0002638_abnormal_pupillary_reflex1.36766681
56MP0005367_renal/urinary_system_phenotyp1.34187831
57MP0000516_abnormal_urinary_system1.34187831
58MP0000569_abnormal_digit_pigmentation1.34097650
59MP0002102_abnormal_ear_morphology1.32581134
60MP0003172_abnormal_lysosome_physiology1.32381203
61MP0003724_increased_susceptibility_to1.32192593
62MP0000778_abnormal_nervous_system1.31951181
63MP0005174_abnormal_tail_pigmentation1.31773123
64MP0002095_abnormal_skin_pigmentation1.30566158
65MP0001968_abnormal_touch/_nociception1.30194328
66MP0005645_abnormal_hypothalamus_physiol1.26817532
67MP0003950_abnormal_plasma_membrane1.26500506
68MP0005266_abnormal_metabolism1.26393851
69MP0001485_abnormal_pinna_reflex1.23843222
70MP0001440_abnormal_grooming_behavior1.23690115
71MP0005451_abnormal_body_composition1.23303034
72MP0003787_abnormal_imprinting1.21913624
73MP0009697_abnormal_copulation1.21551609
74MP0006072_abnormal_retinal_apoptosis1.20795848
75MP0002295_abnormal_pulmonary_circulatio1.16571436
76MP0003718_maternal_effect1.16537596
77MP0002876_abnormal_thyroid_physiology1.15615498
78MP0005332_abnormal_amino_acid1.15413700
79MP0002067_abnormal_sensory_capabilities1.12321642
80MP0002653_abnormal_ependyma_morphology1.12010189
81MP0000604_amyloidosis1.11593900
82MP0000749_muscle_degeneration1.10694571
83MP0004133_heterotaxia1.10357080
84MP0003632_abnormal_nervous_system1.10307597
85MP0001963_abnormal_hearing_physiology1.09699101
86MP0003690_abnormal_glial_cell1.09110015
87MP0002572_abnormal_emotion/affect_behav1.08758059
88MP0002751_abnormal_autonomic_nervous1.08468952
89MP0000462_abnormal_digestive_system1.08233873
90MP0003122_maternal_imprinting1.07815107
91MP0002693_abnormal_pancreas_physiology1.07480685
92MP0005636_abnormal_mineral_homeostasis1.06988813
93MP0002066_abnormal_motor_capabilities/c1.06951852
94MP0008872_abnormal_physiological_respon1.06494000
95MP0000955_abnormal_spinal_cord1.06414899
96MP0001542_abnormal_bone_strength1.05309018
97MP0004924_abnormal_behavior1.00989207
98MP0005386_behavior/neurological_phenoty1.00989207
99MP0003786_premature_aging1.00916279
100MP0002132_abnormal_respiratory_system1.00655725
101MP0002277_abnormal_respiratory_mucosa0.99180760
102MP0009745_abnormal_behavioral_response0.97987582
103MP0002938_white_spotting0.97517013
104MP0004381_abnormal_hair_follicle0.96995903
105MP0001486_abnormal_startle_reflex0.96309127
106MP0002882_abnormal_neuron_morphology0.95662107
107MP0002419_abnormal_innate_immunity0.95457313
108MP0004885_abnormal_endolymph0.94637536
109MP0005646_abnormal_pituitary_gland0.93694168
110MP0008469_abnormal_protein_level0.93261522
111MP0005409_darkened_coat_color0.92816969
112MP0005365_abnormal_bile_salt0.92493712
113MP0004134_abnormal_chest_morphology0.92030142
114MP0006292_abnormal_olfactory_placode0.91497108
115MP0001853_heart_inflammation0.91480859
116MP0005423_abnormal_somatic_nervous0.90043474
117MP0009840_abnormal_foam_cell0.89799465
118MP0005551_abnormal_eye_electrophysiolog0.89511275
119MP0005535_abnormal_body_temperature0.89466298
120MP0000358_abnormal_cell_content/0.89031647
121MP0001501_abnormal_sleep_pattern0.88991741
122MP0000026_abnormal_inner_ear0.87576229
123MP0002184_abnormal_innervation0.86893662
124MP0002752_abnormal_somatic_nervous0.86574352
125MP0008875_abnormal_xenobiotic_pharmacok0.86218744
126MP0005000_abnormal_immune_tolerance0.85669064
127MP0003635_abnormal_synaptic_transmissio0.85644313
128MP0002063_abnormal_learning/memory/cond0.85387434
129MP0005410_abnormal_fertilization0.84697878
130MP0005319_abnormal_enzyme/_coenzyme0.84669952
131MP0001790_abnormal_immune_system0.84287057
132MP0005387_immune_system_phenotype0.84287057
133MP0005310_abnormal_salivary_gland0.83246383
134MP0001664_abnormal_digestion0.82955054
135MP0005025_abnormal_response_to0.82655401
136MP0000685_abnormal_immune_system0.82116078
137MP0003011_delayed_dark_adaptation0.80473497
138MP0001756_abnormal_urination0.80192614
139MP0008789_abnormal_olfactory_epithelium0.79977622
140MP0003252_abnormal_bile_duct0.79868358
141MP0000538_abnormal_urinary_bladder0.79625197
142MP0002723_abnormal_immune_serum0.78201114
143MP0003075_altered_response_to0.77648488
144MP0000343_altered_response_to0.77061603
145MP0005376_homeostasis/metabolism_phenot0.76962809
146MP0010030_abnormal_orbit_morphology0.76516794
147MP0002090_abnormal_vision0.76300779
148MP0002452_abnormal_antigen_presenting0.75718441
149MP0002138_abnormal_hepatobiliary_system0.74608700
150MP0005253_abnormal_eye_physiology0.74504032
151MP0001764_abnormal_homeostasis0.73233369

Predicted human phenotypes

RankGene SetZ-score
1Increased serum pyruvate (HP:0003542)5.78573645
2Abnormality of glycolysis (HP:0004366)5.78573645
3Acute necrotizing encephalopathy (HP:0006965)5.54467309
4Abnormal mitochondria in muscle tissue (HP:0008316)4.99882041
5Mitochondrial inheritance (HP:0001427)4.89656887
6Acute encephalopathy (HP:0006846)4.71299895
7Progressive macrocephaly (HP:0004481)4.45648603
8Increased CSF lactate (HP:0002490)4.15601696
9Hepatocellular necrosis (HP:0001404)4.15147590
10Renal Fanconi syndrome (HP:0001994)4.05520757
11Increased hepatocellular lipid droplets (HP:0006565)3.87166176
12Hepatic necrosis (HP:0002605)3.84000607
13Cerebral edema (HP:0002181)3.57877543
14Leukodystrophy (HP:0002415)3.57660084
15Lipid accumulation in hepatocytes (HP:0006561)3.56852132
16Parakeratosis (HP:0001036)3.51816286
17Abnormality of the anterior horn cell (HP:0006802)3.39653521
18Degeneration of anterior horn cells (HP:0002398)3.39653521
19Cerebral hypomyelination (HP:0006808)3.32733895
20Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.30219068
21Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.22897777
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.17349111
23Increased intramyocellular lipid droplets (HP:0012240)3.05852194
24Pheochromocytoma (HP:0002666)3.05311329
25Respiratory failure (HP:0002878)3.04445778
263-Methylglutaconic aciduria (HP:0003535)3.02204090
27Abnormality of liposaccharide metabolism (HP:0010968)3.00388876
28Abnormality of glycosphingolipid metabolism (HP:0004343)3.00388876
29Abnormality of glycolipid metabolism (HP:0010969)3.00388876
30Lactic acidosis (HP:0003128)2.98785373
31Neuroendocrine neoplasm (HP:0100634)2.98258192
32Type I transferrin isoform profile (HP:0003642)2.93800273
33Exercise intolerance (HP:0003546)2.90630479
34Neurofibrillary tangles (HP:0002185)2.88478148
35Increased serum lactate (HP:0002151)2.87599723
36Glycosuria (HP:0003076)2.85327573
37Abnormality of urine glucose concentration (HP:0011016)2.85327573
38Degeneration of the lateral corticospinal tracts (HP:0002314)2.82452194
39Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.82452194
40Amyotrophic lateral sclerosis (HP:0007354)2.74620913
41Molar tooth sign on MRI (HP:0002419)2.74250820
42Abnormality of midbrain morphology (HP:0002418)2.74250820
43Abolished electroretinogram (ERG) (HP:0000550)2.70969374
44Congenital ichthyosiform erythroderma (HP:0007431)2.69757753
45Abnormality of renal resorption (HP:0011038)2.65967250
46Medial flaring of the eyebrow (HP:0010747)2.65512286
47Hyperphosphaturia (HP:0003109)2.63354382
48Optic disc pallor (HP:0000543)2.59110848
49Abnormal protein glycosylation (HP:0012346)2.59093549
50Abnormal glycosylation (HP:0012345)2.59093549
51Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.59093549
52Abnormal protein N-linked glycosylation (HP:0012347)2.59093549
53Increased muscle lipid content (HP:0009058)2.58666772
54Stomatitis (HP:0010280)2.54075985
55Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.52969180
56Decreased activity of mitochondrial respiratory chain (HP:0008972)2.52969180
57Pancreatic cysts (HP:0001737)2.52597782
58Decreased electroretinogram (ERG) amplitude (HP:0000654)2.44566530
59Aplastic anemia (HP:0001915)2.44493712
60Opisthotonus (HP:0002179)2.38037013
61Nephrogenic diabetes insipidus (HP:0009806)2.37991587
62Pancreatic fibrosis (HP:0100732)2.34930378
63Spastic paraparesis (HP:0002313)2.34624588
64Exertional dyspnea (HP:0002875)2.33667965
65Abnormality of alanine metabolism (HP:0010916)2.32254224
66Hyperalaninemia (HP:0003348)2.32254224
67Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32254224
68Respiratory difficulties (HP:0002880)2.31063139
69Abnormality of dicarboxylic acid metabolism (HP:0010995)2.28930107
70Gait imbalance (HP:0002141)2.28556586
71Atrophy/Degeneration involving motor neurons (HP:0007373)2.28053703
72Hypokalemic alkalosis (HP:0001949)2.26283416
73Hyperglycinemia (HP:0002154)2.25090050
74Microvesicular hepatic steatosis (HP:0001414)2.23142765
75CNS demyelination (HP:0007305)2.22919284
76True hermaphroditism (HP:0010459)2.19819262
77Abnormal urine phosphate concentration (HP:0012599)2.16488917
78Congenital primary aphakia (HP:0007707)2.15948952
79Conjugated hyperbilirubinemia (HP:0002908)2.10295327
80CNS hypomyelination (HP:0003429)2.07400519
81X-linked dominant inheritance (HP:0001423)2.07178978
82Autoamputation (HP:0001218)2.06909326
83Methylmalonic aciduria (HP:0012120)2.05823630
84Abnormality of aromatic amino acid family metabolism (HP:0004338)2.05393004
85Lethargy (HP:0001254)2.04808610
86Upper motor neuron abnormality (HP:0002127)2.04387649
87Vaginal atresia (HP:0000148)2.03904606
88Renal tubular dysfunction (HP:0000124)1.98962222
89Mutism (HP:0002300)1.98275621
90Progressive microcephaly (HP:0000253)1.97013384
91Methylmalonic acidemia (HP:0002912)1.96878601
92Abnormality of methionine metabolism (HP:0010901)1.96504399
93Abnormal pupillary function (HP:0007686)1.96418987
94Genital tract atresia (HP:0001827)1.93516759
95Elevated erythrocyte sedimentation rate (HP:0003565)1.92904080
96Hypothermia (HP:0002045)1.92749668
97Abnormality of the corticospinal tract (HP:0002492)1.92262270
98Abnormality of aspartate family amino acid metabolism (HP:0010899)1.92204467
99Cerebral hemorrhage (HP:0001342)1.89605953
100Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.89296476
101Abnormal rod and cone electroretinograms (HP:0008323)1.88899298
102Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87655522
103Pancytopenia (HP:0001876)1.86938436
104Vacuolated lymphocytes (HP:0001922)1.86624653
105Emotional lability (HP:0000712)1.85379281
106Aplasia/hypoplasia of the uterus (HP:0008684)1.85087925
107Supranuclear gaze palsy (HP:0000605)1.84623251
108Type 2 muscle fiber atrophy (HP:0003554)1.84216723
109Amniotic constriction ring (HP:0009775)1.83183877
110Abnormality of placental membranes (HP:0011409)1.83183877
111Prolonged neonatal jaundice (HP:0006579)1.83101718
112Reduced antithrombin III activity (HP:0001976)1.82605614
113Nephronophthisis (HP:0000090)1.81992598
114Hypoplastic pelvis (HP:0008839)1.81946297
115Split foot (HP:0001839)1.81945024
116Poor suck (HP:0002033)1.81329616
117Ketosis (HP:0001946)1.81268104
118Abnormality of serum amino acid levels (HP:0003112)1.80791037
119Adrenal hypoplasia (HP:0000835)1.80657495
120Cerebral palsy (HP:0100021)1.80395428
121Ketoacidosis (HP:0001993)1.76960274
122Aplasia/Hypoplasia of the sacrum (HP:0008517)1.76644662
123Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.76381951
124Renal salt wasting (HP:0000127)1.75493668
125Myokymia (HP:0002411)1.73968893
126Cerebral inclusion bodies (HP:0100314)1.73203633
127Blindness (HP:0000618)1.72365279
128Gliosis (HP:0002171)1.71671440
129Hypoplastic left heart (HP:0004383)1.71282005
130Sensory axonal neuropathy (HP:0003390)1.70402362
131Limb dystonia (HP:0002451)1.69641273
132Postnatal microcephaly (HP:0005484)1.69498065
133Abnormal umbilical cord blood vessels (HP:0011403)1.68775019
134Single umbilical artery (HP:0001195)1.68775019
135Abnormality of the fetal cardiovascular system (HP:0010948)1.68775019
136Hypoplasia of the uterus (HP:0000013)1.68135170
137Vomiting (HP:0002013)1.67877257
138Stenosis of the external auditory canal (HP:0000402)1.66364226
139Constricted visual fields (HP:0001133)1.66097359
140Congenital, generalized hypertrichosis (HP:0004540)1.66093996
141Sensorimotor neuropathy (HP:0007141)1.65466031
142Nausea (HP:0002018)1.65465743
143Oculomotor apraxia (HP:0000657)1.64934712
144Agitation (HP:0000713)1.63300932
145Generalized aminoaciduria (HP:0002909)1.63170169
146Akinesia (HP:0002304)1.62650814
147Anteriorly placed anus (HP:0001545)1.60951257
148Septate vagina (HP:0001153)1.58574800
149Hepatosplenomegaly (HP:0001433)1.58484656
150Delusions (HP:0000746)1.58458465
151Dicarboxylic aciduria (HP:0003215)1.57691304

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.79588139
2STK163.39208377
3OXSR13.29593230
4PBK2.96726862
5ARAF2.88931682
6BCR2.86934441
7VRK22.80502289
8FRK2.79352424
9BUB12.73390966
10NME12.67093899
11LIMK12.51920773
12WNK42.33548577
13MST42.21162165
14MAP4K22.18344700
15NUAK12.12499442
16TESK22.11752120
17DYRK22.07403345
18BRAF2.00606715
19CDK191.99412463
20MAPKAPK51.97042687
21CASK1.85384409
22EIF2AK31.82304498
23PDK21.77634987
24EIF2AK11.73890733
25MARK11.68218323
26CSNK1G31.66610002
27TAOK31.58613054
28UHMK11.54117338
29EPHB11.50746449
30BCKDK1.39395119
31MET1.39351143
32PIM21.38413484
33TRIM281.33162808
34BMPR1B1.31494788
35KDR1.30776982
36VRK11.29955280
37CAMK2B1.18213272
38PHKG11.16965806
39LMTK21.14405764
40MYLK1.13605502
41CSNK1A1L1.09655938
42CSNK1G21.06550010
43GRK11.05811759
44PKN11.05417635
45NME21.05084174
46IRAK21.04887084
47CSNK1G11.02033872
48CAMK2D1.00810595
49TXK0.98707434
50WNK30.98187978
51CAMKK20.95526340
52ABL20.94173572
53BLK0.93388795
54NEK60.93017124
55KIT0.92912608
56ADRBK20.92633430
57INSRR0.91767650
58ROCK20.90411058
59IKBKB0.87526641
60TESK10.87009474
61CAMK2G0.85839390
62PLK20.85285693
63OBSCN0.85081473
64GRK70.84540727
65PRKCE0.79278818
66SGK2230.78844494
67SGK4940.78844494
68FES0.78332160
69PRPF4B0.77753756
70TNIK0.77210455
71CDK140.76566214
72AURKA0.75405515
73PINK10.71592549
74MAP3K120.70848094
75TSSK60.70267744
76IRAK10.70073546
77MUSK0.67371250
78MAPK150.66978222
79DAPK10.65857338
80PAK30.65575398
81CDK180.65143661
82CCNB10.64964167
83MKNK10.64309980
84PIK3CG0.64214440
85GRK50.64196266
86MAPK130.63770059
87PAK10.61958815
88CAMK2A0.61316598
89TNK20.60552164
90FGFR20.60219031
91DAPK20.60005689
92CDK150.58838251
93SYK0.58774627
94MAP2K20.58661461
95MAP3K110.58337562
96ERBB30.58209371
97ILK0.56904227
98RPS6KA50.56098537
99MAPKAPK30.55729199
100LYN0.52786823
101CDK11A0.52260285
102PRKCQ0.51903267
103MINK10.51326422
104ADRBK10.50163841
105PLK40.49028092
106NEK10.48938233
107ERBB40.48677215
108SRPK10.48226987
109TLK10.47738630
110MAP3K40.47538393
111ACVR1B0.47488944
112MAP2K70.46183367
113NTRK10.45755985
114FGR0.45572818
115AKT30.45088324
116TEC0.44431871
117PNCK0.43819676
118PLK30.43592602
119MAP2K60.43115413
120IRAK30.42433377
121PRKCI0.41652948
122PRKCA0.41309577
123TBK10.41242373
124CSNK2A20.41194544
125BMPR20.40192747
126ZAK0.39160753
127DAPK30.38873566
128MATK0.38178885
129PLK10.37876416
130CSNK1A10.37200778
131CDK50.36881662
132PRKG10.36836000
133PRKACA0.34398411
134PRKCG0.32304332
135CSNK2A10.32210084
136PHKG20.30558772

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.81286983
2Protein export_Homo sapiens_hsa030604.20028180
3Parkinsons disease_Homo sapiens_hsa050123.95198445
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.70020263
5Proteasome_Homo sapiens_hsa030503.62205369
6Fatty acid elongation_Homo sapiens_hsa000622.98856299
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.96605866
8Steroid biosynthesis_Homo sapiens_hsa001002.84386125
9Alzheimers disease_Homo sapiens_hsa050102.83782674
10Huntingtons disease_Homo sapiens_hsa050162.58905937
11RNA polymerase_Homo sapiens_hsa030202.38384263
12Collecting duct acid secretion_Homo sapiens_hsa049662.34289376
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.31339585
14Sulfur metabolism_Homo sapiens_hsa009202.31098384
15Vibrio cholerae infection_Homo sapiens_hsa051102.16571096
16Ribosome_Homo sapiens_hsa030101.98299698
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78012386
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73742939
19Asthma_Homo sapiens_hsa053101.68817619
20Ether lipid metabolism_Homo sapiens_hsa005651.55601525
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.53704503
22Butanoate metabolism_Homo sapiens_hsa006501.44815675
23Cardiac muscle contraction_Homo sapiens_hsa042601.44173682
24Pyruvate metabolism_Homo sapiens_hsa006201.37327603
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.30257511
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.29105159
27Folate biosynthesis_Homo sapiens_hsa007901.28794456
28Type I diabetes mellitus_Homo sapiens_hsa049401.27905689
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26077264
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22663229
31Propanoate metabolism_Homo sapiens_hsa006401.19955086
32Linoleic acid metabolism_Homo sapiens_hsa005911.19250153
33Histidine metabolism_Homo sapiens_hsa003401.18972001
34Glutathione metabolism_Homo sapiens_hsa004801.16901146
35Regulation of autophagy_Homo sapiens_hsa041401.13672822
36Sphingolipid metabolism_Homo sapiens_hsa006001.13019444
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.12676960
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11455493
39Synaptic vesicle cycle_Homo sapiens_hsa047211.09613593
40Phototransduction_Homo sapiens_hsa047441.08672007
41Peroxisome_Homo sapiens_hsa041461.07719338
42Arginine and proline metabolism_Homo sapiens_hsa003301.06133337
43Allograft rejection_Homo sapiens_hsa053301.04770325
44Phagosome_Homo sapiens_hsa041451.02347046
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00087315
46Base excision repair_Homo sapiens_hsa034100.99478502
47Pyrimidine metabolism_Homo sapiens_hsa002400.98856131
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98610063
49Metabolic pathways_Homo sapiens_hsa011000.97999666
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97428562
51Autoimmune thyroid disease_Homo sapiens_hsa053200.90282869
52Rheumatoid arthritis_Homo sapiens_hsa053230.88136076
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.87264099
54Graft-versus-host disease_Homo sapiens_hsa053320.86031519
55Arachidonic acid metabolism_Homo sapiens_hsa005900.85954212
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84496227
57RNA degradation_Homo sapiens_hsa030180.82147707
58Vitamin B6 metabolism_Homo sapiens_hsa007500.79144225
59Nitrogen metabolism_Homo sapiens_hsa009100.78010441
60Tyrosine metabolism_Homo sapiens_hsa003500.76426751
61Lysosome_Homo sapiens_hsa041420.75638557
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75031465
63One carbon pool by folate_Homo sapiens_hsa006700.73708144
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70394790
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68241822
66Primary immunodeficiency_Homo sapiens_hsa053400.67040921
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65234337
68Purine metabolism_Homo sapiens_hsa002300.64643459
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63762124
70Chemical carcinogenesis_Homo sapiens_hsa052040.63594588
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.62627123
72Fatty acid metabolism_Homo sapiens_hsa012120.62203522
73Staphylococcus aureus infection_Homo sapiens_hsa051500.62136050
74Antigen processing and presentation_Homo sapiens_hsa046120.61755784
75Phenylalanine metabolism_Homo sapiens_hsa003600.61686724
76Non-homologous end-joining_Homo sapiens_hsa034500.61419202
77Basal transcription factors_Homo sapiens_hsa030220.60815437
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59255865
79Mismatch repair_Homo sapiens_hsa034300.59150337
80Fanconi anemia pathway_Homo sapiens_hsa034600.58576302
81Carbon metabolism_Homo sapiens_hsa012000.56913606
82Sulfur relay system_Homo sapiens_hsa041220.55418949
83Serotonergic synapse_Homo sapiens_hsa047260.53465746
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50120223
85beta-Alanine metabolism_Homo sapiens_hsa004100.48520348
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47275752
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.46911923
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.45702213
89DNA replication_Homo sapiens_hsa030300.45482181
90Caffeine metabolism_Homo sapiens_hsa002320.43682589
91Selenocompound metabolism_Homo sapiens_hsa004500.42399921
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41694187
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41210005
94Fatty acid degradation_Homo sapiens_hsa000710.40688941
95Nicotine addiction_Homo sapiens_hsa050330.39432093
96RNA transport_Homo sapiens_hsa030130.39166736
97Spliceosome_Homo sapiens_hsa030400.39139397
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39137436
99Tryptophan metabolism_Homo sapiens_hsa003800.38308726
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37886986
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35925469
102Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.34819321
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.33864600
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33811770
105Pentose phosphate pathway_Homo sapiens_hsa000300.32262755
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.31131203
107Biosynthesis of amino acids_Homo sapiens_hsa012300.28406903
108Other glycan degradation_Homo sapiens_hsa005110.27632963
109N-Glycan biosynthesis_Homo sapiens_hsa005100.27123566
110Cocaine addiction_Homo sapiens_hsa050300.26672704
111GABAergic synapse_Homo sapiens_hsa047270.25407194
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25147303
113Fat digestion and absorption_Homo sapiens_hsa049750.24149587
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19946502
115Homologous recombination_Homo sapiens_hsa034400.17924400
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.17601269
117Galactose metabolism_Homo sapiens_hsa000520.17250768
118Retinol metabolism_Homo sapiens_hsa008300.17137299
119Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.16928105
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.16896522
121Mineral absorption_Homo sapiens_hsa049780.16030200
122Fructose and mannose metabolism_Homo sapiens_hsa000510.15785016
123Nucleotide excision repair_Homo sapiens_hsa034200.14087058
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.13782881
125Axon guidance_Homo sapiens_hsa043600.11150221
126Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.10753307
127Vitamin digestion and absorption_Homo sapiens_hsa049770.10324788
128Taste transduction_Homo sapiens_hsa047420.08868527

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