COMP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* cartilage development involved in endochondral bone morphogenesis (GO:0060351)9.54747134
2collagen fibril organization (GO:0030199)9.17527635
3positive regulation of extracellular matrix organization (GO:1903055)7.15857645
4notochord development (GO:0030903)6.77110786
5endochondral ossification (GO:0001958)6.44205067
6replacement ossification (GO:0036075)6.44205067
7limb bud formation (GO:0060174)6.28854190
8collagen catabolic process (GO:0030574)6.11010599
9virion attachment to host cell (GO:0019062)6.00206799
10adhesion of symbiont to host cell (GO:0044650)6.00206799
11negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)5.92538770
12chondroitin sulfate biosynthetic process (GO:0030206)5.91554501
13peptidyl-proline hydroxylation (GO:0019511)5.90835986
14collagen metabolic process (GO:0032963)5.89052002
15multicellular organismal catabolic process (GO:0044243)5.63684139
16proteoglycan metabolic process (GO:0006029)5.60214787
17keratan sulfate biosynthetic process (GO:0018146)5.59413585
18sphingomyelin metabolic process (GO:0006684)5.57060185
19multicellular organismal macromolecule metabolic process (GO:0044259)5.54278324
20positive regulation of chondrocyte differentiation (GO:0032332)5.52518942
21sequestering of extracellular ligand from receptor (GO:0035581)5.46310286
22nucleotide-sugar biosynthetic process (GO:0009226)5.34796997
23iron ion import (GO:0097286)5.29569576
24endothelial cell morphogenesis (GO:0001886)5.28630057
25* cartilage development (GO:0051216)5.24945208
26multicellular organismal metabolic process (GO:0044236)5.24833986
27regulation of extracellular matrix disassembly (GO:0010715)5.24213664
28protein heterotrimerization (GO:0070208)5.04640870
29positive regulation of cartilage development (GO:0061036)4.98525180
30chondrocyte differentiation (GO:0002062)4.93492630
31peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.91629723
32embryonic skeletal joint morphogenesis (GO:0060272)4.86689262
33cell migration involved in heart development (GO:0060973)4.84469500
34protein retention in ER lumen (GO:0006621)4.84356196
35adhesion of symbiont to host (GO:0044406)4.83100374
36protein hydroxylation (GO:0018126)4.81781936
37extracellular matrix disassembly (GO:0022617)4.81410825
38hypotonic response (GO:0006971)4.73759015
39response to gravity (GO:0009629)4.64773394
40keratan sulfate metabolic process (GO:0042339)4.64088203
41chondrocyte proliferation (GO:0035988)4.58263050
42maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.55229665
43regulation of plasminogen activation (GO:0010755)4.53442761
44* skeletal system development (GO:0001501)4.52546492
45bone trabecula formation (GO:0060346)4.43334595
46skin morphogenesis (GO:0043589)4.26510117
47regulation of extracellular matrix organization (GO:1903053)4.23976203
48metanephric mesenchyme development (GO:0072075)4.22017872
49lipopolysaccharide biosynthetic process (GO:0009103)4.18897075
50cellular glucuronidation (GO:0052695)4.18677357
51kidney mesenchyme development (GO:0072074)4.12947006
52regulation of response to osmotic stress (GO:0047484)4.03819968
53fibril organization (GO:0097435)4.00845346
54glycosaminoglycan biosynthetic process (GO:0006024)4.00345824
55aminoglycan biosynthetic process (GO:0006023)3.96052907
56endodermal cell differentiation (GO:0035987)3.95610385
57sulfur compound catabolic process (GO:0044273)3.91731548
58ossification (GO:0001503)3.90261667
59response to BMP (GO:0071772)3.86253766
60cellular response to BMP stimulus (GO:0071773)3.86253766
61* extracellular matrix organization (GO:0030198)3.84301251
62* extracellular structure organization (GO:0043062)3.83446431
63glycosaminoglycan catabolic process (GO:0006027)3.82157922
64regulation of chondrocyte differentiation (GO:0032330)3.80114531
65glucuronate metabolic process (GO:0019585)3.78017808
66uronic acid metabolic process (GO:0006063)3.78017808
67short-term memory (GO:0007614)3.76762185
68UDP-N-acetylglucosamine metabolic process (GO:0006047)3.74480155
69regulation of cartilage development (GO:0061035)3.72594089
70aminoglycan catabolic process (GO:0006026)3.58073297
71glycoprotein metabolic process (GO:0009100)3.55418313
72myelin assembly (GO:0032288)3.55377071
73lipopolysaccharide metabolic process (GO:0008653)3.53392580
74behavioral response to nicotine (GO:0035095)3.52736906
75extracellular regulation of signal transduction (GO:1900115)3.49324625
76extracellular negative regulation of signal transduction (GO:1900116)3.49324625
77positive regulation of fatty acid beta-oxidation (GO:0032000)3.48863792
78axon extension involved in axon guidance (GO:0048846)3.47860957
79neuron projection extension involved in neuron projection guidance (GO:1902284)3.47860957
80dermatan sulfate biosynthetic process (GO:0030208)3.46800072
814-hydroxyproline metabolic process (GO:0019471)3.46709506
82chondroitin sulfate metabolic process (GO:0030204)3.43956063
83bone development (GO:0060348)3.39958433
84positive regulation of fatty acid oxidation (GO:0046321)3.39850652
85negative regulation of leukocyte chemotaxis (GO:0002689)3.38850936
86positive regulation of osteoblast proliferation (GO:0033690)3.37952923
87proteoglycan biosynthetic process (GO:0030166)3.34838131
88tooth mineralization (GO:0034505)3.32708911
89blood vessel maturation (GO:0001955)3.32526726
90positive regulation of hormone biosynthetic process (GO:0046886)3.30999079
91fusion of sperm to egg plasma membrane (GO:0007342)3.30932991
92type B pancreatic cell proliferation (GO:0044342)3.30501538
93COPII vesicle coating (GO:0048208)3.29057054
94COPI coating of Golgi vesicle (GO:0048205)3.26476117
95Golgi transport vesicle coating (GO:0048200)3.26476117
96glomerular basement membrane development (GO:0032836)3.25316375
97positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.24389545
98regulation of bone mineralization (GO:0030500)3.22791412
99negative regulation of BMP signaling pathway (GO:0030514)3.22484226
100smooth muscle tissue development (GO:0048745)3.18226679
101dermatan sulfate metabolic process (GO:0030205)3.13812868
102nucleotide-sugar metabolic process (GO:0009225)3.09563870
103regulation of biomineral tissue development (GO:0070167)3.07476827
104negative regulation of cartilage development (GO:0061037)3.07391750
105middle ear morphogenesis (GO:0042474)3.07354639
106embryonic viscerocranium morphogenesis (GO:0048703)3.04927778
107mesenchymal-epithelial cell signaling (GO:0060638)3.04750106
108lymphangiogenesis (GO:0001946)3.03918911
109behavioral response to pain (GO:0048266)3.03307203
110endocardial cushion morphogenesis (GO:0003203)3.03275678
111mucopolysaccharide metabolic process (GO:1903510)3.02750825
112vascular endothelial growth factor signaling pathway (GO:0038084)3.02655785
113negative regulation of gluconeogenesis (GO:0045721)3.01792148
114extracellular matrix assembly (GO:0085029)3.00664060
115hyperosmotic salinity response (GO:0042538)2.96786132
116outer ear morphogenesis (GO:0042473)2.96230943
117endocrine hormone secretion (GO:0060986)2.94080851
118chondroitin sulfate catabolic process (GO:0030207)2.93046528
119somite development (GO:0061053)2.92483205
120bone mineralization (GO:0030282)2.90551849
121biomineral tissue development (GO:0031214)2.88373962
122response to magnesium ion (GO:0032026)2.86731199
123extracellular fibril organization (GO:0043206)2.84676061
124negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.82847491
125regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.82480901
126parturition (GO:0007567)2.81351287
127regulation of phospholipase A2 activity (GO:0032429)2.80648198
128* connective tissue development (GO:0061448)2.80319916
129type B pancreatic cell development (GO:0003323)2.80283700
130cell proliferation involved in metanephros development (GO:0072203)2.77076657
131regulation of steroid hormone biosynthetic process (GO:0090030)2.76074949
132response to misfolded protein (GO:0051788)2.75858286
133regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.72224185
134cellular response to vitamin (GO:0071295)2.67670848
135protein trimerization (GO:0070206)2.67596198
136regulation of integrin-mediated signaling pathway (GO:2001044)2.61755883
137negative chemotaxis (GO:0050919)2.56439806
138muscle cell migration (GO:0014812)2.55192067
139aorta morphogenesis (GO:0035909)2.51892785
140camera-type eye morphogenesis (GO:0048593)2.51396425
141regulation of BMP signaling pathway (GO:0030510)2.49020169
142negative regulation of nitric-oxide synthase activity (GO:0051001)2.43167982
143negative regulation of axon extension involved in axon guidance (GO:0048843)2.42548068
144regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.41985900
145negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.39244349
146negative regulation of platelet activation (GO:0010544)2.38293490
147myelination in peripheral nervous system (GO:0022011)2.37700412
148peripheral nervous system axon ensheathment (GO:0032292)2.37700412
149positive regulation of metanephros development (GO:0072216)2.35940220
150endocardial cushion development (GO:0003197)2.32129854
151negative regulation of protein localization to cell surface (GO:2000009)2.31973542
152embryonic cranial skeleton morphogenesis (GO:0048701)2.30835291
153myoblast migration (GO:0051451)2.27463167
154artery development (GO:0060840)2.27460487
155glomerular filtration (GO:0003094)2.26625081
156substrate-dependent cell migration (GO:0006929)2.24319536
157negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.24153713
158positive regulation of collagen biosynthetic process (GO:0032967)2.23657719
159regulation of interleukin-8 secretion (GO:2000482)2.23178900
160keratan sulfate catabolic process (GO:0042340)12.1170082
161chondrocyte development (GO:0002063)10.7412318
162cartilage condensation (GO:0001502)10.3779205
163cell aggregation (GO:0098743)10.3779205

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human8.28735377
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.13562056
3EZH2_22144423_ChIP-Seq_EOC_Human4.04574593
4AR_21572438_ChIP-Seq_LNCaP_Human3.67487749
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.27982579
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.18762625
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.18177478
8SMAD_19615063_ChIP-ChIP_OVARY_Human3.11733897
9GATA1_22025678_ChIP-Seq_K562_Human2.58843728
10CJUN_26792858_Chip-Seq_BT549_Human2.50441020
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.48182534
12TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.46456802
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.36964622
14* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.22940563
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.11586539
16CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.11468950
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.08763046
18WT1_19549856_ChIP-ChIP_CCG9911_Human1.98349517
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.93080434
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91373871
21EZH2_27294783_Chip-Seq_ESCs_Mouse1.86603679
22GBX2_23144817_ChIP-Seq_PC3_Human1.82040103
23ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.81530210
24JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.79297209
25CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.75122567
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71081528
27* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69960910
28DROSHA_22980978_ChIP-Seq_HELA_Human1.63566721
29* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61406740
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55203881
31* EZH2_27304074_Chip-Seq_ESCs_Mouse1.54236260
32SMC3_22415368_ChIP-Seq_MEFs_Mouse1.53108227
33* EED_16625203_ChIP-ChIP_MESCs_Mouse1.50852805
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.48312034
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44075951
36PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.42505777
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41265339
38TBX20_22328084_ChIP-Seq_HEART_Mouse1.40779168
39TBX20_22080862_ChIP-Seq_HEART_Mouse1.40779168
40SA1_22415368_ChIP-Seq_MEFs_Mouse1.39666983
41TP53_16413492_ChIP-PET_HCT116_Human1.38988941
42SMC1_22415368_ChIP-Seq_MEFs_Mouse1.37872381
43JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37147964
44HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.36932311
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36173918
46NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35124642
47NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35124642
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34998940
49CLOCK_20551151_ChIP-Seq_293T_Human1.34956782
50* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32306790
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32106494
52FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31672147
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.31015232
54BRD4_25478319_ChIP-Seq_HGPS_Human1.27893835
55* RING1B_27294783_Chip-Seq_ESCs_Mouse1.26487085
56BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26332853
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25537484
58VDR_24787735_ChIP-Seq_THP-1_Human1.25450236
59TP53_18474530_ChIP-ChIP_U2OS_Human1.25301440
60EGR1_19032775_ChIP-ChIP_M12_Human1.25067100
61NFIB_24661679_ChIP-Seq_LUNG_Mouse1.24786205
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23818859
63EP300_21415370_ChIP-Seq_HL-1_Mouse1.20134010
64* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.18404854
65TP53_23651856_ChIP-Seq_MEFs_Mouse1.17929905
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17570204
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.16378222
68EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13881630
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.12662115
70ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.12442709
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.11201773
72ZNF274_21170338_ChIP-Seq_K562_Hela1.10771203
73* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09740603
74* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09740603
75* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09671793
76* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.08686174
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07241148
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07125949
79CSB_26484114_Chip-Seq_FIBROBLAST_Human1.06426665
80* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05953018
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05806076
82SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01023400
83SOX2_20726797_ChIP-Seq_SW620_Human1.00190387
84CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97060290
85GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96324926
86* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.96307743
87CTCF_27219007_Chip-Seq_Bcells_Human0.95658802
88CRX_20693478_ChIP-Seq_RETINA_Mouse0.94879172
89CTCF_21964334_Chip-Seq_Bcells_Human0.94816381
90CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94664252
91* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.93376838
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93026966
93RXR_22108803_ChIP-Seq_LS180_Human0.93018660
94FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.91826912
95SMAD3_21741376_ChIP-Seq_EPCs_Human0.91524909
96* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91040605
97NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90403097
98SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.89615087
99* RNF2_27304074_Chip-Seq_ESCs_Mouse0.89478561
100WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88980977
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88006597
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88006597
103SMAD4_21741376_ChIP-Seq_EPCs_Human0.87859976
104TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87496397
105TP53_20018659_ChIP-ChIP_R1E_Mouse0.87118055
106ELK4_26923725_Chip-Seq_MESODERM_Mouse0.86740299
107BCAT_22108803_ChIP-Seq_LS180_Human0.86407632
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84531281
109MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84230787
110PIAS1_25552417_ChIP-Seq_VCAP_Human0.83227474
111GF1_26923725_Chip-Seq_HPCs_Mouse0.83106728
112FOXM1_26456572_ChIP-Seq_MCF-7_Human0.82894351
113P63_26484246_Chip-Seq_KERATINOCYTES_Human0.82844377
114TP53_22127205_ChIP-Seq_IMR90_Human0.82630099
115TP63_23658742_ChIP-Seq_EP156T_Human0.82227367
116TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82224000
117SOX9_24532713_ChIP-Seq_HFSC_Mouse0.81792573
118JARID2_20064375_ChIP-Seq_MESCs_Mouse0.81596285
119KDM2B_26808549_Chip-Seq_REH_Human0.81309620
120NR3C1_23031785_ChIP-Seq_PC12_Mouse0.80780354
121LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.80481285
122SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.80373540
123SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.79904261
124SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.79904261
125RING1B_27294783_Chip-Seq_NPCs_Mouse0.79749570
126FOXO3_23340844_ChIP-Seq_DLD1_Human0.79346681
127DNAJC2_21179169_ChIP-ChIP_NT2_Human0.78488292
128* FOXH1_21741376_ChIP-Seq_ESCs_Human0.78383785
129CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.77917200
130GATA3_24758297_ChIP-Seq_MCF-7_Human0.77812780
131EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.77462373
132GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77068833
133EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.77057557
134ELK1_22589737_ChIP-Seq_MCF10A_Human0.76926002
135GF1B_26923725_Chip-Seq_HPCs_Mouse0.76701804
136NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.76659030
137RAD21_21589869_ChIP-Seq_MESCs_Mouse0.76639519
138TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.76612147
139SMAD4_21799915_ChIP-Seq_A2780_Human0.76463335
140TOP2B_26459242_ChIP-Seq_MCF-7_Human0.76368511
141AHR_22903824_ChIP-Seq_MCF-7_Human0.76209312
142VDR_22108803_ChIP-Seq_LS180_Human0.74629166
143CTCF_20526341_ChIP-Seq_ESCs_Human0.74212317
144CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.72568959
145THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.71407474
146MYC_19829295_ChIP-Seq_ESCs_Human0.70809657

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.82749572
2MP0004134_abnormal_chest_morphology5.73764191
3* MP0005503_abnormal_tendon_morphology5.46641537
4* MP0002933_joint_inflammation4.62191285
5MP0005275_abnormal_skin_tensile4.53882670
6MP0002282_abnormal_trachea_morphology4.50340915
7* MP0000163_abnormal_cartilage_morphology3.63315988
8* MP0009250_abnormal_appendicular_skeleto3.15305585
9* MP0002115_abnormal_skeleton_extremities3.14128801
10MP0003283_abnormal_digestive_organ3.09038773
11MP0001542_abnormal_bone_strength2.95999348
12MP0009384_cardiac_valve_regurgitation2.86724599
13MP0003279_aneurysm2.86315273
14MP0002896_abnormal_bone_mineralization2.78246588
15MP0009780_abnormal_chondrocyte_physiolo2.73060352
16* MP0002113_abnormal_skeleton_development2.54790219
17* MP0005508_abnormal_skeleton_morphology2.46467703
18MP0001533_abnormal_skeleton_physiology2.41431928
19MP0003705_abnormal_hypodermis_morpholog2.34140799
20* MP0005390_skeleton_phenotype2.28703179
21MP0002089_abnormal_postnatal_growth/wei2.19439820
22MP0001299_abnormal_eye_distance/2.17252718
23MP0001958_emphysema2.11219714
24MP0000762_abnormal_tongue_morphology2.05030072
25* MP0002109_abnormal_limb_morphology2.01791553
26MP0002909_abnormal_adrenal_gland1.97051880
27MP0001270_distended_abdomen1.94479002
28* MP0002108_abnormal_muscle_morphology1.91778556
29MP0003795_abnormal_bone_structure1.90169711
30MP0005410_abnormal_fertilization1.81056581
31MP0004272_abnormal_basement_membrane1.80207811
32MP0010368_abnormal_lymphatic_system1.59716215
33MP0002998_abnormal_bone_remodeling1.58313808
34MP0002116_abnormal_craniofacial_bone1.52611592
35MP0005023_abnormal_wound_healing1.48876753
36MP0005171_absent_coat_pigmentation1.40547826
37MP0003123_paternal_imprinting1.32011532
38MP0003755_abnormal_palate_morphology1.30211613
39MP0005257_abnormal_intraocular_pressure1.30195700
40MP0003566_abnormal_cell_adhesion1.29904220
41MP0000432_abnormal_head_morphology1.28620605
42MP0004130_abnormal_muscle_cell1.28254585
43MP0010386_abnormal_urinary_bladder1.25104205
44MP0000049_abnormal_middle_ear1.24455593
45MP0002060_abnormal_skin_morphology1.20575490
46MP0000343_altered_response_to1.19156152
47MP0002295_abnormal_pulmonary_circulatio1.14018992
48MP0002254_reproductive_system_inflammat1.13232831
49MP0002111_abnormal_tail_morphology1.12546367
50MP0004084_abnormal_cardiac_muscle1.12020510
51MP0003656_abnormal_erythrocyte_physiolo1.10520907
52MP0002233_abnormal_nose_morphology1.10201648
53MP0001243_abnormal_dermal_layer1.05913005
54MP0002114_abnormal_axial_skeleton1.05317881
55MP0002876_abnormal_thyroid_physiology1.04064881
56MP0003436_decreased_susceptibility_to1.02506625
57MP0004885_abnormal_endolymph0.98107576
58MP0005623_abnormal_meninges_morphology0.94495102
59MP0008004_abnormal_stomach_pH0.93456973
60MP0000230_abnormal_systemic_arterial0.92102422
61MP0000462_abnormal_digestive_system0.91927231
62MP0004858_abnormal_nervous_system0.91443212
63MP0003937_abnormal_limbs/digits/tail_de0.89357385
64MP0003385_abnormal_body_wall0.88078126
65MP0003935_abnormal_craniofacial_develop0.86862114
66MP0001879_abnormal_lymphatic_vessel0.86592316
67MP0004484_altered_response_of0.85201746
68MP0009379_abnormal_foot_pigmentation0.84497150
69MP0006054_spinal_hemorrhage0.84279886
70MP0003091_abnormal_cell_migration0.84065100
71MP0001348_abnormal_lacrimal_gland0.82058482
72MP0005164_abnormal_response_to0.80606069
73MP0004145_abnormal_muscle_electrophysio0.79385863
74MP0004036_abnormal_muscle_relaxation0.79144480
75MP0002249_abnormal_larynx_morphology0.78099921
76MP0005381_digestive/alimentary_phenotyp0.77029690
77MP0004197_abnormal_fetal_growth/weight/0.75170768
78MP0000749_muscle_degeneration0.73171755
79MP0000538_abnormal_urinary_bladder0.72020892
80MP0010030_abnormal_orbit_morphology0.70944661
81MP0005670_abnormal_white_adipose0.70788882
82MP0004133_heterotaxia0.69741508
83MP0002163_abnormal_gland_morphology0.68937839
84* MP0000751_myopathy0.67255115
85MP0003011_delayed_dark_adaptation0.66912467
86MP0000026_abnormal_inner_ear0.65229767
87* MP0002932_abnormal_joint_morphology0.64833079
88MP0001663_abnormal_digestive_system0.63268822
89MP0003195_calcinosis0.62597880
90MP0003942_abnormal_urinary_system0.61585613
91MP0002168_other_aberrant_phenotype0.60271669
92MP0004883_abnormal_blood_vessel0.59298042
93MP0005388_respiratory_system_phenotype0.59218318
94MP0002133_abnormal_respiratory_system0.59218318
95MP0002160_abnormal_reproductive_system0.58846914
96MP0001661_extended_life_span0.58832365
97* MP0005369_muscle_phenotype0.58401345
98MP0001756_abnormal_urination0.56495118
99MP0005076_abnormal_cell_differentiation0.55975523
100MP0000428_abnormal_craniofacial_morphol0.55570357
101MP0000767_abnormal_smooth_muscle0.55142341
102MP0005551_abnormal_eye_electrophysiolog0.52073394
103MP0001963_abnormal_hearing_physiology0.52058072
104MP0000681_abnormal_thyroid_gland0.51248271
105MP0002234_abnormal_pharynx_morphology0.50399704
106MP0001943_abnormal_respiration0.50307420
107MP0003724_increased_susceptibility_to0.49908395
108MP0000604_amyloidosis0.49766841
109MP0003122_maternal_imprinting0.49494035
110MP0005389_reproductive_system_phenotype0.49330686
111MP0000467_abnormal_esophagus_morphology0.49141140
112MP0003448_altered_tumor_morphology0.48890573
113MP0008775_abnormal_heart_ventricle0.47256945
114MP0000013_abnormal_adipose_tissue0.47158201
115MP0010771_integument_phenotype0.46722623
116MP0002128_abnormal_blood_circulation0.46597868
117MP0003879_abnormal_hair_cell0.46472223
118MP0000465_gastrointestinal_hemorrhage0.46259741
119MP0005620_abnormal_muscle_contractility0.44923769
120MP0000747_muscle_weakness0.44653566
121MP0001502_abnormal_circadian_rhythm0.44155562
122MP0002638_abnormal_pupillary_reflex0.44080628
123MP0002837_dystrophic_cardiac_calcinosis0.44002091
124MP0002653_abnormal_ependyma_morphology0.43421504
125* MP0003646_muscle_fatigue0.42614621
126MP0003329_amyloid_beta_deposits0.42109383
127MP0003787_abnormal_imprinting0.41081579
128MP0001905_abnormal_dopamine_level0.40511127
129MP0009697_abnormal_copulation0.40319084
130MP0001968_abnormal_touch/_nociception0.39870766
131MP0000733_abnormal_muscle_development0.39328828
132MP0001175_abnormal_lung_morphology0.39196108
133MP0004185_abnormal_adipocyte_glucose0.38163949
134MP0005595_abnormal_vascular_smooth0.36849504
135MP0005193_abnormal_anterior_eye0.35799295
136MP0002735_abnormal_chemical_nociception0.35590052
137MP0000750_abnormal_muscle_regeneration0.35423689
138MP0005166_decreased_susceptibility_to0.34793183
139MP0000534_abnormal_ureter_morphology0.34687254
140MP0003121_genomic_imprinting0.33142672
141* MP0000759_abnormal_skeletal_muscle0.31828955

Predicted human phenotypes

RankGene SetZ-score
1* Epiphyseal dysplasia (HP:0002656)8.64653848
2* Irregular epiphyses (HP:0010582)7.68108447
3Vitreoretinal degeneration (HP:0000655)6.91364854
4Hypoplastic ischia (HP:0003175)6.33452709
5Cupped ribs (HP:0000887)6.08705304
6Abnormal tarsal ossification (HP:0008369)6.04962235
7Metaphyseal cupping (HP:0003021)5.92661599
8Flat capital femoral epiphysis (HP:0003370)5.75967107
9Abnormality of the ischium (HP:0003174)5.59973863
10Aplasia/Hypoplasia of the pubic bone (HP:0009104)5.46950434
11* Small epiphyses (HP:0010585)5.10391999
12Flat acetabular roof (HP:0003180)5.03274649
13* Genu varum (HP:0002970)5.01225829
14Soft skin (HP:0000977)5.00253029
15Aortic aneurysm (HP:0004942)4.97625365
16Aortic dissection (HP:0002647)4.80733817
17Bladder diverticulum (HP:0000015)4.70940963
18Neonatal short-limb short stature (HP:0008921)4.59491748
19Flattened epiphyses (HP:0003071)4.56605918
20Abnormal foot bone ossification (HP:0010675)4.43529427
21Metaphyseal dysplasia (HP:0100255)4.34441543
22Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)4.29696912
23Absent epiphyses (HP:0010577)4.29696912
24* Abnormality involving the epiphyses of the lower limbs (HP:0006500)4.26648661
25* Abnormality of femoral epiphyses (HP:0006499)4.26648661
26Broad metatarsal (HP:0001783)4.25824056
27* Delayed epiphyseal ossification (HP:0002663)4.21584966
28Peritonitis (HP:0002586)4.07862280
29Ankle contracture (HP:0006466)3.95091342
30* Osteoarthritis (HP:0002758)3.93853329
31Coxa vara (HP:0002812)3.92051240
32* Abnormality of the epiphysis of the femoral head (HP:0010574)3.89252085
33Wrist flexion contracture (HP:0001239)3.82198598
34* Abnormality of the vertebral endplates (HP:0005106)3.81315539
35Arthropathy (HP:0003040)3.79584429
36Vascular tortuosity (HP:0004948)3.66492290
37Aortic valve stenosis (HP:0001650)3.58929079
38* Abnormality of the femoral head (HP:0003368)3.57885125
39Enlarged epiphyses (HP:0010580)3.56997700
40Bowel diverticulosis (HP:0005222)3.53737031
41Shallow orbits (HP:0000586)3.52778783
42Overgrowth (HP:0001548)3.51631747
43* Mild short stature (HP:0003502)3.45972046
44* Joint stiffness (HP:0001387)3.44390612
45Abnormality of carpal bone ossification (HP:0006257)3.37576326
46Atrophic scars (HP:0001075)3.34583478
47Type 1 muscle fiber predominance (HP:0003803)3.33611134
48Abnormal vertebral ossification (HP:0100569)3.33271479
49* Platyspondyly (HP:0000926)3.30727251
50Abnormality of the proximal phalanges of the hand (HP:0009834)3.29420077
51* Short femoral neck (HP:0100864)3.25870836
52* Irregular vertebral endplates (HP:0003301)3.22444753
53Fragile skin (HP:0001030)3.21625826
54Cervical subluxation (HP:0003308)3.20855517
55* Genu recurvatum (HP:0002816)3.20579906
56Abnormality of the phalanges of the 2nd finger (HP:0009541)3.17440824
57Protuberant abdomen (HP:0001538)3.14675952
58Abnormality of dentin (HP:0010299)3.14473176
59Slender build (HP:0001533)3.13607810
60Pulmonary artery stenosis (HP:0004415)3.13332858
61Mesomelia (HP:0003027)3.12819602
62Dilatation of the ascending aorta (HP:0005111)3.12650146
63Barrel-shaped chest (HP:0001552)3.11887286
64Abnormality of the pubic bones (HP:0003172)3.11142974
65Increased corneal curvature (HP:0100692)3.05979577
66Keratoconus (HP:0000563)3.05979577
67Protrusio acetabuli (HP:0003179)3.03993700
68Aortic regurgitation (HP:0001659)3.01533080
69* Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.99746595
70Thoracolumbar scoliosis (HP:0002944)2.94663348
71* Waddling gait (HP:0002515)2.94551709
72Hip contracture (HP:0003273)2.92376160
73Vertebral clefting (HP:0008428)2.91664389
74Round ear (HP:0100830)2.79026311
75Exostoses (HP:0100777)2.75373589
76Stillbirth (HP:0003826)2.73476707
77Abnormal hand bone ossification (HP:0010660)2.72442072
78Premature rupture of membranes (HP:0001788)2.70931366
79Abnormal ossification of hand bones (HP:0005921)2.66581253
80Infantile muscular hypotonia (HP:0008947)2.65062041
81* Metaphyseal irregularity (HP:0003025)2.62609464
82Spinal rigidity (HP:0003306)2.62438217
83Spondylolisthesis (HP:0003302)2.62382370
84Redundant skin (HP:0001582)2.61526615
85Morphological abnormality of the middle ear (HP:0008609)2.60025979
86Blue sclerae (HP:0000592)2.59357498
87Abnormality of the acetabulum (HP:0003170)2.58108797
88* Broad ribs (HP:0000885)2.54320236
89Tibial bowing (HP:0002982)2.52952226
90* Lumbar hyperlordosis (HP:0002938)2.51465114
91Hyperextensible skin (HP:0000974)2.49260497
92Femoral bowing (HP:0002980)2.48781131
93Absent frontal sinuses (HP:0002688)2.44726974
94Abnormality of the 2nd finger (HP:0004100)2.44620486
95Short middle phalanx of finger (HP:0005819)2.43183918
96Relative macrocephaly (HP:0004482)2.41017550
97* Aplasia/hypoplasia of the femur (HP:0005613)2.38399158
98* Limited hip movement (HP:0008800)2.37065659
99* Joint laxity (HP:0001388)2.36833227
100Thin ribs (HP:0000883)2.35605832
101* Limited elbow extension (HP:0001377)2.35455558
102Fibular hypoplasia (HP:0003038)2.34585093
103Wide anterior fontanel (HP:0000260)2.33438428
104Vertebral compression fractures (HP:0002953)2.33183519
105* Ovoid vertebral bodies (HP:0003300)2.30401071
106Flared metaphyses (HP:0003015)2.29992813
107Striae distensae (HP:0001065)2.28598204
108Mitral valve prolapse (HP:0001634)2.28550079
109Rhizomelia (HP:0008905)2.28276834
110Radial bowing (HP:0002986)2.27890370
111Abnormality of the middle phalanges of the toes (HP:0010183)2.27463128
112Abnormality of the lumbar spine (HP:0100712)2.26564637
113Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.24656208
114Broad phalanx (HP:0006009)2.24484023
115Mitral stenosis (HP:0001718)2.24427238
116Flat cornea (HP:0007720)2.24104626
117Broad long bones (HP:0005622)2.22969020
118Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.22748136
119Mitral regurgitation (HP:0001653)2.20880099
120* Micromelia (HP:0002983)2.20791101
121Arterial tortuosity (HP:0005116)2.20489184
122Patent foramen ovale (HP:0001655)2.19909842
123Disproportionate short-trunk short stature (HP:0003521)2.19234358
124Abnormality of the anterior chamber (HP:0000593)2.18639268
125Glossoptosis (HP:0000162)2.18506257
126* Beaking of vertebral bodies (HP:0004568)2.16180155
127Follicular hyperkeratosis (HP:0007502)2.14152811
128Hypoventilation (HP:0002791)2.14073638
129Abnormality of the vitreous humor (HP:0004327)2.12359500
130* Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.12003196
131Short ribs (HP:0000773)2.06270690
132Abnormal delivery (HP:0001787)2.05075366
133Abnormality of incisor morphology (HP:0011063)2.05044105
134Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.04327663
135Cerebral aneurysm (HP:0004944)2.03269453
136Mesangial abnormality (HP:0001966)2.02068129
137Emphysema (HP:0002097)2.01881206
138Thin bony cortex (HP:0002753)2.00243227
139Short hallux (HP:0010109)1.99579373
140Ulnar bowing (HP:0003031)1.98599713
141Bowed forearm bones (HP:0003956)1.97424159
142Bowing of the arm (HP:0006488)1.97424159
143Hypoplastic ilia (HP:0000946)1.97032172
144Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.96902652
145Long clavicles (HP:0000890)1.96288017
146Bulbous nose (HP:0000414)1.95997005
147Abnormality of the phalanges of the 5th finger (HP:0004213)1.94357684
148Cardiovascular calcification (HP:0011915)1.93102613
149Hypoplastic pelvis (HP:0008839)1.92499847
150Narrow nasal bridge (HP:0000446)1.91867180
151Biconcave vertebral bodies (HP:0004586)1.90829526
152Mildly elevated creatine phosphokinase (HP:0008180)1.90204510
153Papilledema (HP:0001085)1.89886787
154Aplasia/Hypoplasia of the hallux (HP:0008362)1.89554034
155Tubular atrophy (HP:0000092)1.88711664
156Megalocornea (HP:0000485)1.88542894
157Nephronophthisis (HP:0000090)1.88402547
158Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.87761655
159Congenital, generalized hypertrichosis (HP:0004540)1.87274782
160Wormian bones (HP:0002645)1.86888453
161Broad phalanges of the hand (HP:0009768)1.86076684
162Abnormality of the middle phalanges of the hand (HP:0009833)1.85039133
163Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.84866356
164Vertebral hypoplasia (HP:0008417)1.84866356
165Deviation of the hallux (HP:0010051)1.84834498
166Mixed hearing impairment (HP:0000410)1.84644135
167Ectopia lentis (HP:0001083)1.84585789
168Hallux valgus (HP:0001822)1.84447290
169Persistence of primary teeth (HP:0006335)1.81715893
170Flared iliac wings (HP:0002869)1.81699553
171Elbow flexion contracture (HP:0002987)1.81508157
172Coronal craniosynostosis (HP:0004440)1.80161649
173Renovascular hypertension (HP:0100817)1.79749534
174Gingival overgrowth (HP:0000212)1.77513772
175Systemic lupus erythematosus (HP:0002725)1.73615901
176Venous insufficiency (HP:0005293)1.70785779
177Premature skin wrinkling (HP:0100678)1.69968981

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR28.83314256
2STK38L5.71647445
3STK245.30563381
4MAP3K35.25624428
5PRKG23.44282775
6MYLK3.40602705
7NME13.11641554
8FRK3.10930769
9KIT2.73002056
10PDK22.46849239
11ADRBK22.38530083
12MAPKAPK32.27209596
13PRKD22.23590776
14TLK12.20159227
15STK32.14774489
16GRK12.05694950
17TIE11.99344449
18LATS11.77114209
19MAP3K61.68530490
20LATS21.60848207
21MAPK151.59366535
22ERBB31.59258866
23PDK31.57451581
24PDK41.57451581
25PIM21.55946838
26LIMK11.54978583
27SIK11.54756131
28INSRR1.53738829
29TRIB31.52007394
30PRKD31.51578143
31ABL21.48385440
32PLK21.45653458
33TAOK11.41946122
34TESK11.34280579
35RIPK11.32590289
36CDC42BPA1.28502384
37MUSK1.25570091
38WNK41.23337611
39MARK11.10579532
40PIK3CA1.09288204
41MST41.07494767
42EPHA31.07087936
43NUAK11.05639500
44NME21.02738028
45PTK2B1.01335044
46DYRK20.99034073
47RPS6KA20.97305866
48TRPM70.92282014
49CASK0.91809301
50TTN0.91510673
51MAPK70.90689792
52STK390.89642296
53PRKCE0.89306689
54DAPK30.89069428
55MAPK120.86174325
56PKN10.86055126
57ROCK10.84358935
58CAMKK20.82786490
59PRKD10.81906382
60EPHB10.81900112
61RPS6KA60.81014580
62DAPK20.80034577
63PRKCG0.79957380
64CAMK10.78366544
65NEK60.78143352
66DYRK1A0.76238858
67MAPK130.75108341
68MET0.74260781
69PKN20.73118588
70TAOK30.72591759
71MAP3K70.71810886
72WNK30.71265495
73FGFR30.71005655
74MARK20.69194466
75FLT30.69079883
76MAP4K20.67623316
77ERBB20.65813069
78HIPK20.65299887
79MAP2K60.63368188
80EPHA20.63196455
81ERN10.62281594
82GSK3A0.61122495
83MAP2K30.60782743
84SGK2230.60610644
85SGK4940.60610644
86ILK0.60178119
87EIF2AK30.59648964
88MAP2K20.57680987
89NLK0.57281402
90PBK0.57238707
91BCKDK0.54500473
92ICK0.54155730
93RPS6KL10.53776989
94RPS6KC10.53776989
95MAPKAPK50.51079714
96FGFR10.49770491
97TGFBR20.49612347
98ACVR1B0.48951180
99TXK0.48803353
100IKBKB0.48596001
101CHUK0.46962717
102MAPK40.46895083
103NTRK10.46605722
104FER0.43937806
105PRKCA0.43761906
106PRKAA20.43509794
107PRKG10.43442290
108EPHB20.42676160
109PDGFRA0.40325206
110RPS6KA50.40264969
111ABL10.40140659
112PRKCZ0.39730389
113CAMKK10.39532785
114OBSCN0.39412249
115CSNK1A10.38628768
116TGFBR10.38468719
117PDGFRB0.38337102
118PAK30.37567228
119SGK20.37019138
120JAK10.34219434
121BMPR1B0.32728277
122PHKG10.31787690
123PHKG20.31787690
124PDK10.30697867
125CSF1R0.29197837
126ADRBK10.27964867
127MST1R0.27961998
128MELK0.27916196
129PAK20.27263107
130PRKACG0.24661525
131TAOK20.21939456
132PIM10.21379559
133PINK10.20689586
134KSR10.20450017
135PRKCD0.20122627
136PTK20.19646929
137DYRK1B0.19218012
138WNK10.19154390
139IGF1R0.18796221
140MTOR0.18065246
141STK380.17445481
142NEK90.17394708
143MAPK10.17328215
144MAP2K10.16201733
145INSR0.14856549
146BMX0.14394713
147MAPK100.14258464
148MAPK30.13928833
149PAK40.13205788
150MAP3K110.12495482
151GRK50.11958877
152PLK30.11370552
153RET0.11188362
154MKNK20.10101217
155SGK10.10037274
156PRKCH0.09982576
157PTK60.09788848
158PRKACA0.08998145

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005327.72213959
2* ECM-receptor interaction_Homo sapiens_hsa045126.46991257
3Protein digestion and absorption_Homo sapiens_hsa049746.11078660
4* Focal adhesion_Homo sapiens_hsa045102.68917623
5Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.41658602
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.12417729
7Sphingolipid metabolism_Homo sapiens_hsa006002.09194985
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.88329779
9TGF-beta signaling pathway_Homo sapiens_hsa043501.87813652
10Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.86356168
11* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.81781181
12Starch and sucrose metabolism_Homo sapiens_hsa005001.78539044
13Sulfur metabolism_Homo sapiens_hsa009201.76746867
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.75866946
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.75539133
16Linoleic acid metabolism_Homo sapiens_hsa005911.67368269
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.56986280
18Phototransduction_Homo sapiens_hsa047441.56606897
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53729842
20Olfactory transduction_Homo sapiens_hsa047401.43482327
21Steroid biosynthesis_Homo sapiens_hsa001001.43412806
22Hedgehog signaling pathway_Homo sapiens_hsa043401.43023776
23Vascular smooth muscle contraction_Homo sapiens_hsa042701.36479001
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36473935
25* Malaria_Homo sapiens_hsa051441.36269125
26Protein export_Homo sapiens_hsa030601.34408718
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.33843374
28Sulfur relay system_Homo sapiens_hsa041221.33664517
29Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.19150192
30Proteoglycans in cancer_Homo sapiens_hsa052051.19095625
31Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.18282739
32Oxidative phosphorylation_Homo sapiens_hsa001901.15478112
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13678848
34Arginine and proline metabolism_Homo sapiens_hsa003301.12675192
35Melanoma_Homo sapiens_hsa052181.12655971
36Selenocompound metabolism_Homo sapiens_hsa004501.11110775
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10002507
38ABC transporters_Homo sapiens_hsa020101.06431727
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06309746
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05978607
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05354465
42Hippo signaling pathway_Homo sapiens_hsa043901.03995690
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03861711
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03301129
45Basal cell carcinoma_Homo sapiens_hsa052171.03258612
46Galactose metabolism_Homo sapiens_hsa000521.02669528
47Axon guidance_Homo sapiens_hsa043601.02237402
48Staphylococcus aureus infection_Homo sapiens_hsa051501.01609519
49Dilated cardiomyopathy_Homo sapiens_hsa054141.00147673
50Other glycan degradation_Homo sapiens_hsa005110.99347776
51Ovarian steroidogenesis_Homo sapiens_hsa049130.96438010
52Folate biosynthesis_Homo sapiens_hsa007900.95546424
53Nitrogen metabolism_Homo sapiens_hsa009100.93456012
54Cardiac muscle contraction_Homo sapiens_hsa042600.90708613
55Chemical carcinogenesis_Homo sapiens_hsa052040.90563497
56N-Glycan biosynthesis_Homo sapiens_hsa005100.86506129
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.86056904
58Tryptophan metabolism_Homo sapiens_hsa003800.83697401
59Morphine addiction_Homo sapiens_hsa050320.83232079
60Ribosome_Homo sapiens_hsa030100.82617039
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82389176
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.82345800
63Calcium signaling pathway_Homo sapiens_hsa040200.82167434
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.81781335
65Nicotine addiction_Homo sapiens_hsa050330.80660120
66HIF-1 signaling pathway_Homo sapiens_hsa040660.79077666
67Renin-angiotensin system_Homo sapiens_hsa046140.78960736
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78423560
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78366791
70Alzheimers disease_Homo sapiens_hsa050100.76421839
71Glycerolipid metabolism_Homo sapiens_hsa005610.75971274
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72559004
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70874603
74Ether lipid metabolism_Homo sapiens_hsa005650.70691551
75Glucagon signaling pathway_Homo sapiens_hsa049220.68777353
76Thyroid hormone synthesis_Homo sapiens_hsa049180.68664391
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68175048
78Taste transduction_Homo sapiens_hsa047420.66025408
79Ras signaling pathway_Homo sapiens_hsa040140.65444975
80Arachidonic acid metabolism_Homo sapiens_hsa005900.65315974
81Wnt signaling pathway_Homo sapiens_hsa043100.63992539
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.63498841
83Lysosome_Homo sapiens_hsa041420.63297293
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62998234
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.62460120
86Amoebiasis_Homo sapiens_hsa051460.62454575
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61500781
88Parkinsons disease_Homo sapiens_hsa050120.60012088
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60002087
90Glutamatergic synapse_Homo sapiens_hsa047240.58445694
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57903732
92Serotonergic synapse_Homo sapiens_hsa047260.57587782
93Vibrio cholerae infection_Homo sapiens_hsa051100.55700611
94* Phagosome_Homo sapiens_hsa041450.55538956
95Insulin resistance_Homo sapiens_hsa049310.55189085
96Retinol metabolism_Homo sapiens_hsa008300.53884475
97Bladder cancer_Homo sapiens_hsa052190.53690092
98Lysine degradation_Homo sapiens_hsa003100.53169757
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.51213690
100GABAergic synapse_Homo sapiens_hsa047270.51116072
101Caffeine metabolism_Homo sapiens_hsa002320.49263110
102Adherens junction_Homo sapiens_hsa045200.49221336
103Rheumatoid arthritis_Homo sapiens_hsa053230.47720922
104Pertussis_Homo sapiens_hsa051330.47135143
105Tyrosine metabolism_Homo sapiens_hsa003500.46175731
106Salivary secretion_Homo sapiens_hsa049700.46064452
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45812739
108Legionellosis_Homo sapiens_hsa051340.45280380
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44906639
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44650581
111Rap1 signaling pathway_Homo sapiens_hsa040150.44116012
112Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43999728
113MAPK signaling pathway_Homo sapiens_hsa040100.43936527
114Melanogenesis_Homo sapiens_hsa049160.42639235
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.41906830
116Long-term depression_Homo sapiens_hsa047300.41701694
117Fat digestion and absorption_Homo sapiens_hsa049750.41568335
118Platelet activation_Homo sapiens_hsa046110.40950603
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40019449
120Complement and coagulation cascades_Homo sapiens_hsa046100.39712747
121Oxytocin signaling pathway_Homo sapiens_hsa049210.38173643
122Gap junction_Homo sapiens_hsa045400.37469923
123Mineral absorption_Homo sapiens_hsa049780.36118688
124Osteoclast differentiation_Homo sapiens_hsa043800.34770487
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34430255
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34289501
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32929744
128Prostate cancer_Homo sapiens_hsa052150.30962940
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30038670
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29730244
131HTLV-I infection_Homo sapiens_hsa051660.28775716
132Fructose and mannose metabolism_Homo sapiens_hsa000510.28404307
133Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28115786
134Hepatitis B_Homo sapiens_hsa051610.27510296
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27053641
136Circadian entrainment_Homo sapiens_hsa047130.26796235
137Aldosterone synthesis and secretion_Homo sapiens_hsa049250.26594760
138AMPK signaling pathway_Homo sapiens_hsa041520.26368524
139Estrogen signaling pathway_Homo sapiens_hsa049150.26176096
140Amphetamine addiction_Homo sapiens_hsa050310.25623577
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25350616
142Renin secretion_Homo sapiens_hsa049240.24144195
143TNF signaling pathway_Homo sapiens_hsa046680.24139932
144Cocaine addiction_Homo sapiens_hsa050300.21542295
145MicroRNAs in cancer_Homo sapiens_hsa052060.21294934
146SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20849594
147PPAR signaling pathway_Homo sapiens_hsa033200.18842981
148Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.18532641
149cAMP signaling pathway_Homo sapiens_hsa040240.18354995
150Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.17482547
151Pyruvate metabolism_Homo sapiens_hsa006200.16727048
152Small cell lung cancer_Homo sapiens_hsa052220.14939979
153Pathways in cancer_Homo sapiens_hsa052000.14060275
154Vitamin digestion and absorption_Homo sapiens_hsa049770.13705498
155Insulin secretion_Homo sapiens_hsa049110.13665376

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