COMTD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.18122288
2viral transcription (GO:0019083)6.79876607
3DNA deamination (GO:0045006)6.62420331
4translational termination (GO:0006415)6.57434388
5ribosomal small subunit biogenesis (GO:0042274)6.21142649
6GDP-mannose metabolic process (GO:0019673)6.15172319
7translational elongation (GO:0006414)5.76286982
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.72895602
9cotranslational protein targeting to membrane (GO:0006613)5.60894657
10protein targeting to ER (GO:0045047)5.58325846
11maturation of SSU-rRNA (GO:0030490)5.50745852
12negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)5.42432578
13establishment of protein localization to endoplasmic reticulum (GO:0072599)5.30534223
14protein localization to endoplasmic reticulum (GO:0070972)5.30227738
15viral life cycle (GO:0019058)5.18361820
16cellular protein complex disassembly (GO:0043624)5.10699889
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.03682931
18translational initiation (GO:0006413)5.03303720
19ribosomal large subunit biogenesis (GO:0042273)4.71366093
20protein complex disassembly (GO:0043241)4.41886564
21proline biosynthetic process (GO:0006561)4.41102852
22macromolecular complex disassembly (GO:0032984)4.21902118
23peptidyl-arginine omega-N-methylation (GO:0035247)4.16013474
24ribonucleoprotein complex biogenesis (GO:0022613)4.15674171
25translation (GO:0006412)4.14691031
26NADH metabolic process (GO:0006734)4.12437329
27protein maturation by protein folding (GO:0022417)4.07602395
28regulation of mammary gland epithelial cell proliferation (GO:0033599)4.07027993
29proteasome assembly (GO:0043248)4.06011566
30amyloid precursor protein catabolic process (GO:0042987)4.00742206
31telomere maintenance via semi-conservative replication (GO:0032201)3.97848333
32DNA strand elongation involved in DNA replication (GO:0006271)3.86688792
33formation of translation preinitiation complex (GO:0001731)3.85227612
34deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.75364780
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.71250864
36guanosine-containing compound biosynthetic process (GO:1901070)3.70785352
37nuclear-transcribed mRNA catabolic process (GO:0000956)3.68664400
38DNA strand elongation (GO:0022616)3.67708798
39UTP biosynthetic process (GO:0006228)3.64995060
40protein targeting to membrane (GO:0006612)3.64861522
41pentose metabolic process (GO:0019321)3.62511548
42histone arginine methylation (GO:0034969)3.55729331
43rRNA processing (GO:0006364)3.51115890
44mRNA catabolic process (GO:0006402)3.50623620
45GTP biosynthetic process (GO:0006183)3.45801957
46pseudouridine synthesis (GO:0001522)3.45156504
47cellular component biogenesis (GO:0044085)3.42135109
48protein retention in ER lumen (GO:0006621)3.37981930
49DNA replication initiation (GO:0006270)3.37947713
50amyloid precursor protein metabolic process (GO:0042982)3.36507322
51rRNA metabolic process (GO:0016072)3.35775661
52energy coupled proton transport, down electrochemical gradient (GO:0015985)3.34471481
53ATP synthesis coupled proton transport (GO:0015986)3.34471481
54telomere maintenance via recombination (GO:0000722)3.34426359
55RNA catabolic process (GO:0006401)3.33766273
56mitochondrial fusion (GO:0008053)3.31753226
57UTP metabolic process (GO:0046051)3.31048969
58pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.30528332
59apoptotic process involved in morphogenesis (GO:0060561)3.30480440
60peptidyl-arginine N-methylation (GO:0035246)3.29027033
61peptidyl-arginine methylation (GO:0018216)3.29027033
62regulation of apoptotic process involved in morphogenesis (GO:1902337)3.22241082
63response to interferon-beta (GO:0035456)3.22215270
64sulfur amino acid catabolic process (GO:0000098)3.20693063
65ribosome biogenesis (GO:0042254)3.19235811
66spliceosomal snRNP assembly (GO:0000387)3.17632170
67CTP metabolic process (GO:0046036)3.14952804
68CTP biosynthetic process (GO:0006241)3.14952804
69IMP biosynthetic process (GO:0006188)3.13930865
70proline metabolic process (GO:0006560)3.12099987
71DNA replication checkpoint (GO:0000076)3.11014468
72pyrimidine nucleotide catabolic process (GO:0006244)3.07448991
73pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.07329461
74pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.06401708
75positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.06291912
76nuclear envelope reassembly (GO:0031468)3.05549209
77mitotic nuclear envelope reassembly (GO:0007084)3.05549209
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.05503387
79nucleobase-containing small molecule interconversion (GO:0015949)3.04039411
80regulation of translational fidelity (GO:0006450)3.01881079
81antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.00925904
82folic acid metabolic process (GO:0046655)3.00490292
83termination of RNA polymerase III transcription (GO:0006386)2.98514366
84transcription elongation from RNA polymerase III promoter (GO:0006385)2.98514366
85protein insertion into membrane (GO:0051205)2.98473709
86purine-containing compound salvage (GO:0043101)2.98422476
87folic acid-containing compound biosynthetic process (GO:0009396)2.96785227
88negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.96168874
89nucleobase biosynthetic process (GO:0046112)2.95033516
90regulation of protein heterodimerization activity (GO:0043497)2.94231262
91respiratory electron transport chain (GO:0022904)2.94223807
92establishment of protein localization to mitochondrial membrane (GO:0090151)2.93709306
93maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.93611199
94establishment of integrated proviral latency (GO:0075713)2.93033102
95regulation of mitochondrial translation (GO:0070129)2.91845113
96regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.91679616
97telomere maintenance via telomere lengthening (GO:0010833)2.91230869
98nucleotide salvage (GO:0043173)2.90488630
99mitotic recombination (GO:0006312)2.90178904
100pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.89965190
101electron transport chain (GO:0022900)2.88318264
102rRNA transcription (GO:0009303)2.87652952
103desmosome organization (GO:0002934)2.87279538
104oxidative phosphorylation (GO:0006119)2.87151036
105IMP metabolic process (GO:0046040)2.86429418
106nucleoside diphosphate biosynthetic process (GO:0009133)2.85795847
107COPI coating of Golgi vesicle (GO:0048205)2.85582969
108Golgi transport vesicle coating (GO:0048200)2.85582969
109DNA unwinding involved in DNA replication (GO:0006268)2.85343555
110pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.84599845
111exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.82426273
112mannose metabolic process (GO:0006013)2.82282228
113monosaccharide biosynthetic process (GO:0046364)2.82233989
114viral mRNA export from host cell nucleus (GO:0046784)2.81600259
115rRNA modification (GO:0000154)2.81046936
116glucose catabolic process (GO:0006007)2.78585974
117DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.77634393
118glucose 6-phosphate metabolic process (GO:0051156)2.77168408
119negative regulation of cell size (GO:0045792)2.76837935
120gluconeogenesis (GO:0006094)2.76501367
121hexose biosynthetic process (GO:0019319)2.74745247
122ribonucleoside triphosphate biosynthetic process (GO:0009201)2.74598244
123heme biosynthetic process (GO:0006783)2.74009569
124signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.72894376
125intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.72894376
126oxaloacetate metabolic process (GO:0006107)2.72174279
127purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.71552304
128nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.71315490
129establishment of protein localization to mitochondrion (GO:0072655)2.71125945
130positive regulation of Cdc42 GTPase activity (GO:0043089)2.70857919
131endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.70674323
132protein targeting to mitochondrion (GO:0006626)2.70302748
133metallo-sulfur cluster assembly (GO:0031163)2.70208014
134iron-sulfur cluster assembly (GO:0016226)2.70208014
135pteridine-containing compound biosynthetic process (GO:0042559)2.69953332
136urea cycle (GO:0000050)2.69710041
137purine nucleoside triphosphate biosynthetic process (GO:0009145)2.69481935
138L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.69338806
139negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.69245768
140negative regulation of ligase activity (GO:0051352)2.69245768
141signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.68401680
142signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.68401680
143signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.68401680
144purine nucleotide salvage (GO:0032261)2.67469974
1452-deoxyribonucleotide biosynthetic process (GO:0009265)2.67133519
146deoxyribose phosphate biosynthetic process (GO:0046385)2.67133519
147transcription from mitochondrial promoter (GO:0006390)2.67127328
148deoxyribonucleotide catabolic process (GO:0009264)2.67092231
149positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.66948730
150regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.66626236
151regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.64532275
152pentose-phosphate shunt (GO:0006098)2.63999976
153spliceosomal complex assembly (GO:0000245)2.63336416
154nucleotide-excision repair, DNA gap filling (GO:0006297)2.62671176
155respiratory chain complex IV assembly (GO:0008535)2.62471885
156L-phenylalanine metabolic process (GO:0006558)2.61654901
157erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.61654901
158ncRNA processing (GO:0034470)2.60730357
159signal transduction involved in DNA damage checkpoint (GO:0072422)2.60440035
160signal transduction involved in DNA integrity checkpoint (GO:0072401)2.60440035
161protein localization to mitochondrion (GO:0070585)2.59762253
162anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.59641065
163prostaglandin biosynthetic process (GO:0001516)2.59636301
164prostanoid biosynthetic process (GO:0046457)2.59636301
165establishment of protein localization to membrane (GO:0090150)2.59303374
166pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.58824746
167negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.58740459
168ncRNA 3-end processing (GO:0043628)2.57479736
169peptidyl-histidine modification (GO:0018202)2.54228955

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.56579860
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.43219935
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.32179745
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.05818672
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.03159061
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00040756
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.94952247
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.93051195
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.89539447
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.85848863
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.76577421
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.66188188
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.60435658
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.60168492
15LXR_22292898_ChIP-Seq_THP-1_Human2.57565686
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.55215489
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.48990090
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45947092
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.33285448
20XRN2_22483619_ChIP-Seq_HELA_Human2.30830178
21* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.30821514
22* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.29697227
23ZNF263_19887448_ChIP-Seq_K562_Human2.23999587
24TP63_17297297_ChIP-ChIP_HaCaT_Human2.23229319
25* VDR_23849224_ChIP-Seq_CD4+_Human2.21754106
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.14075229
27DCP1A_22483619_ChIP-Seq_HELA_Human2.09421338
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06664331
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06325612
30* RACK7_27058665_Chip-Seq_MCF-7_Human2.05904919
31TET1_21451524_ChIP-Seq_MESCs_Mouse2.01535080
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00291817
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99909646
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.90238424
35GABP_19822575_ChIP-Seq_HepG2_Human1.85267102
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.84455706
37FOXP3_21729870_ChIP-Seq_TREG_Human1.83047548
38TTF2_22483619_ChIP-Seq_HELA_Human1.82222357
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.81522132
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.79988002
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79683555
42VDR_21846776_ChIP-Seq_THP-1_Human1.77723266
43P68_20966046_ChIP-Seq_HELA_Human1.77411757
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.77378917
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.75474447
46* SRF_21415370_ChIP-Seq_HL-1_Mouse1.73901908
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.71996386
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.66843869
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.66743349
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64372925
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.64029960
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63836404
53MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.60503767
54ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.60411674
55SPI1_23547873_ChIP-Seq_NB4_Human1.57982474
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57897535
57* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57887057
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.57607051
59CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.55068925
60CIITA_25753668_ChIP-Seq_RAJI_Human1.54600895
61ELK1_19687146_ChIP-ChIP_HELA_Human1.52745190
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52660187
63* SA1_27219007_Chip-Seq_ERYTHROID_Human1.52407749
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50615721
65MYC_22102868_ChIP-Seq_BL_Human1.47413614
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.46795233
67* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45507405
68BCL6_27268052_Chip-Seq_Bcells_Human1.45506091
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45498776
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43714461
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43133628
72NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43125848
73MYB_21317192_ChIP-Seq_ERMYB_Mouse1.42548507
74BCOR_27268052_Chip-Seq_Bcells_Human1.42106257
75SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.40775741
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.40219643
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39727647
78FOXM1_23109430_ChIP-Seq_U2OS_Human1.38521641
79MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38350610
80CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37842706
81* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36488026
82* CTCF_26484167_Chip-Seq_Bcells_Mouse1.34274557
83SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.33279848
84ERG_21242973_ChIP-ChIP_JURKAT_Human1.30409469
85* TFEB_21752829_ChIP-Seq_HELA_Human1.30026136
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.29781520
87* E2F1_21310950_ChIP-Seq_MCF-7_Human1.29648086
88SCL_19346495_ChIP-Seq_HPC-7_Human1.29540129
89NOTCH1_21737748_ChIP-Seq_TLL_Human1.29477529
90* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.29116067
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29115632
92ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.26415781
93SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26248672
94* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26096328
95CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25254970
96PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24634890
97KDM2B_26808549_Chip-Seq_DND41_Human1.24058814
98E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23794923
99* FOXP1_21924763_ChIP-Seq_HESCs_Human1.23780805
100MAF_26560356_Chip-Seq_TH2_Human1.23256801
101SMC4_20622854_ChIP-Seq_HELA_Human1.23060697
102SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.22074547
103* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.21511011
104PHF8_20622854_ChIP-Seq_HELA_Human1.20568728
105ATF3_27146783_Chip-Seq_COLON_Human1.18383341
106GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18280740
107CREB1_26743006_Chip-Seq_LNCaP_Human1.18243180
108CTCF_21964334_Chip-Seq_Bcells_Human1.16703516
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16635507
110TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15933499
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15910290
112CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15144963
113TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14862253
114ELK1_22589737_ChIP-Seq_MCF10A_Human1.14539373
115SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13649732
116MYC_18940864_ChIP-ChIP_HL60_Human1.13569108
117E2F1_20622854_ChIP-Seq_HELA_Human1.12724998
118* SA1_27219007_Chip-Seq_Bcells_Human1.12581075
119RARA_24833708_ChIP-Seq_LIVER_Mouse1.10925668
120ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09866049
121MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09792436
122* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09578789
123* CTCF_27219007_Chip-Seq_Bcells_Human1.09489492
124* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08910083
125BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08209631
126* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.08032778
127* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.07382903
128* RUNX1_22412390_ChIP-Seq_EML_Mouse1.06406128
129SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05920195
130EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05864741
131MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05428861
132PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05373952
133EGR1_19374776_ChIP-ChIP_THP-1_Human1.04242720
134CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04117822
135* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04083178
136ETS1_21867929_ChIP-Seq_TH2_Mouse1.03900191
137CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03875628
138PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03471931
139VDR_24763502_ChIP-Seq_THP-1_Human1.02762296
140* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01825449
141KDM5A_27292631_Chip-Seq_BREAST_Human1.01366823
142PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00582253
143HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00100501
144KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00053433
145CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98402301
146* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97690080
147BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96639132
148POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95070964
149KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94416660
150* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93817331
151POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93408305
152GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92550839
153* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92125159

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.34199486
2MP0003693_abnormal_embryo_hatching3.89902224
3MP0010234_abnormal_vibrissa_follicle3.85766592
4MP0009379_abnormal_foot_pigmentation3.37515530
5MP0000678_abnormal_parathyroid_gland3.26524151
6MP0001835_abnormal_antigen_presentation3.03694985
7MP0004957_abnormal_blastocyst_morpholog3.00596376
8MP0002796_impaired_skin_barrier2.87562363
9MP0002396_abnormal_hematopoietic_system2.81498032
10MP0005174_abnormal_tail_pigmentation2.64060239
11MP0010094_abnormal_chromosome_stability2.63203077
12MP0002163_abnormal_gland_morphology2.59332567
13MP0004858_abnormal_nervous_system2.55830061
14MP0009785_altered_susceptibility_to2.51496486
15MP0003436_decreased_susceptibility_to2.51311470
16MP0003111_abnormal_nucleus_morphology2.49498835
17MP0008057_abnormal_DNA_replication2.48004929
18MP0005501_abnormal_skin_physiology2.44797141
19MP0004185_abnormal_adipocyte_glucose2.44600936
20MP0003077_abnormal_cell_cycle2.42731456
21MP0000490_abnormal_crypts_of2.38946348
22MP0009333_abnormal_splenocyte_physiolog2.38357932
23MP0005397_hematopoietic_system_phenotyp2.37608871
24MP0001545_abnormal_hematopoietic_system2.37608871
25MP0002148_abnormal_hypersensitivity_rea2.24856520
26MP0008058_abnormal_DNA_repair2.21949276
27MP0003186_abnormal_redox_activity2.18011008
28MP0005025_abnormal_response_to2.16019376
29MP0002249_abnormal_larynx_morphology2.12886373
30MP0000685_abnormal_immune_system2.10110971
31MP0001853_heart_inflammation2.09398157
32MP0005000_abnormal_immune_tolerance1.98127572
33MP0008007_abnormal_cellular_replicative1.97735406
34MP0005671_abnormal_response_to1.91872996
35MP0003656_abnormal_erythrocyte_physiolo1.90510126
36MP0005075_abnormal_melanosome_morpholog1.89026845
37MP0001661_extended_life_span1.88493589
38MP0003724_increased_susceptibility_to1.85871578
39MP0003453_abnormal_keratinocyte_physiol1.84859118
40MP0002419_abnormal_innate_immunity1.82509772
41MP0002398_abnormal_bone_marrow1.82316277
42MP0002139_abnormal_hepatobiliary_system1.81527030
43MP0005670_abnormal_white_adipose1.78399929
44MP0000858_altered_metastatic_potential1.77595931
45MP0005360_urolithiasis1.77511233
46MP0002452_abnormal_antigen_presenting1.75915188
47MP0002877_abnormal_melanocyte_morpholog1.73324402
48MP0000689_abnormal_spleen_morphology1.71438762
49MP0006036_abnormal_mitochondrial_physio1.70484297
50MP0002822_catalepsy1.69474002
51MP0005464_abnormal_platelet_physiology1.69436181
52MP0002420_abnormal_adaptive_immunity1.68945775
53MP0002723_abnormal_immune_serum1.68062861
54MP0001819_abnormal_immune_cell1.67825644
55MP0001800_abnormal_humoral_immune1.67811125
56MP0003763_abnormal_thymus_physiology1.65789645
57MP0008260_abnormal_autophagy1.65711769
58MP0010352_gastrointestinal_tract_polyps1.63664287
59MP0005666_abnormal_adipose_tissue1.61670412
60MP0003123_paternal_imprinting1.61593919
61MP0003806_abnormal_nucleotide_metabolis1.61363292
62MP0002722_abnormal_immune_system1.59884525
63MP0001346_abnormal_lacrimal_gland1.57583285
64MP0003303_peritoneal_inflammation1.57310893
65MP0005083_abnormal_biliary_tract1.55426250
66MP0000003_abnormal_adipose_tissue1.53149321
67MP0002429_abnormal_blood_cell1.52683444
68MP0004808_abnormal_hematopoietic_stem1.51754423
69MP0000343_altered_response_to1.51612287
70MP0000716_abnormal_immune_system1.50409483
71MP0004264_abnormal_extraembryonic_tissu1.48580576
72MP0002405_respiratory_system_inflammati1.44148290
73MP0000681_abnormal_thyroid_gland1.42440480
74MP0005375_adipose_tissue_phenotype1.42357041
75MP0002234_abnormal_pharynx_morphology1.41431432
76MP0002019_abnormal_tumor_incidence1.38596716
77MP0002132_abnormal_respiratory_system1.34318952
78MP0000372_irregular_coat_pigmentation1.33016361
79MP0003705_abnormal_hypodermis_morpholog1.32961412
80MP0000313_abnormal_cell_death1.29748955
81MP0004147_increased_porphyrin_level1.28535623
82MP0006054_spinal_hemorrhage1.27900696
83MP0005623_abnormal_meninges_morphology1.27492116
84MP0008932_abnormal_embryonic_tissue1.27449552
85MP0001845_abnormal_inflammatory_respons1.27048353
86MP0006082_CNS_inflammation1.26869516
87MP0000015_abnormal_ear_pigmentation1.26736227
88MP0001188_hyperpigmentation1.25706234
89MP0005379_endocrine/exocrine_gland_phen1.25285022
90MP0010155_abnormal_intestine_physiology1.24904903
91MP0006035_abnormal_mitochondrial_morpho1.24617098
92MP0000537_abnormal_urethra_morphology1.21464660
93MP0000358_abnormal_cell_content/1.21382208
94MP0009643_abnormal_urine_homeostasis1.20746713
95MP0005058_abnormal_lysosome_morphology1.20713255
96MP0005332_abnormal_amino_acid1.19972496
97MP0003172_abnormal_lysosome_physiology1.19316271
98MP0002095_abnormal_skin_pigmentation1.19191678
99MP0008469_abnormal_protein_level1.17922991
100MP0001216_abnormal_epidermal_layer1.16322973
101MP0005330_cardiomyopathy1.15965830
102MP0004019_abnormal_vitamin_homeostasis1.15144244
103MP0000350_abnormal_cell_proliferation1.14332468
104MP0002098_abnormal_vibrissa_morphology1.13691996
105MP0003191_abnormal_cellular_cholesterol1.12061717
106MP0005365_abnormal_bile_salt1.11730854
107MP0001666_abnormal_nutrient_absorption1.10648957
108MP0000703_abnormal_thymus_morphology1.09960772
109MP0003866_abnormal_defecation1.09137095
110MP0001663_abnormal_digestive_system1.08199851
111MP0004510_myositis1.04537869
112MP0010030_abnormal_orbit_morphology1.03578307
113MP0001873_stomach_inflammation1.01774934
114MP0002006_tumorigenesis1.00515199
115MP0003786_premature_aging1.00475373
116MP0004233_abnormal_muscle_weight0.99802618
117MP0001348_abnormal_lacrimal_gland0.99629452
118MP0001790_abnormal_immune_system0.99338278
119MP0005387_immune_system_phenotype0.99338278
120MP0009840_abnormal_foam_cell0.98259458
121MP0001849_ear_inflammation0.97824068
122MP0003315_abnormal_perineum_morphology0.97448267
123MP0002166_altered_tumor_susceptibility0.97446850
124MP0003448_altered_tumor_morphology0.97195297
125MP0005076_abnormal_cell_differentiation0.95463884
126MP0001727_abnormal_embryo_implantation0.94880758
127MP0005584_abnormal_enzyme/coenzyme_acti0.94465210
128MP0005266_abnormal_metabolism0.92881767
129MP0001986_abnormal_taste_sensitivity0.91072884
130MP0000477_abnormal_intestine_morphology0.90631464
131MP0010307_abnormal_tumor_latency0.90470246
132MP0003879_abnormal_hair_cell0.89799431
133MP0006292_abnormal_olfactory_placode0.89638958
134MP0000538_abnormal_urinary_bladder0.89602214
135MP0000467_abnormal_esophagus_morphology0.89390122
136MP0001533_abnormal_skeleton_physiology0.88866772
137MP0004782_abnormal_surfactant_physiolog0.88791968
138MP0004947_skin_inflammation0.88092927
139MP0001730_embryonic_growth_arrest0.86405697
140MP0009053_abnormal_anal_canal0.85348598
141MP0005319_abnormal_enzyme/_coenzyme0.84965974
142MP0005636_abnormal_mineral_homeostasis0.84583284
143MP0001664_abnormal_digestion0.83613511
144MP0009931_abnormal_skin_appearance0.83358722
145MP0000371_diluted_coat_color0.80836293
146MP0001881_abnormal_mammary_gland0.80364216
147MP0001919_abnormal_reproductive_system0.80262786
148MP0002089_abnormal_postnatal_growth/wei0.79596824
149MP0000750_abnormal_muscle_regeneration0.78353952
150MP0000747_muscle_weakness0.78209281
151MP0008873_increased_physiological_sensi0.77815121
152MP0010771_integument_phenotype0.77472406
153MP0003828_pulmonary_edema0.76626547
154MP0002332_abnormal_exercise_endurance0.76494991
155MP0000013_abnormal_adipose_tissue0.75984493
156MP0002080_prenatal_lethality0.74991585
157MP0009764_decreased_sensitivity_to0.71709107
158MP0002075_abnormal_coat/hair_pigmentati0.71167189
159MP0005376_homeostasis/metabolism_phenot0.70998843
160MP0001764_abnormal_homeostasis0.70102458
161MP0000609_abnormal_liver_physiology0.70090408
162MP0000462_abnormal_digestive_system0.69755339
163MP0005023_abnormal_wound_healing0.69623788
164MP0003718_maternal_effect0.67287742
165MP0002138_abnormal_hepatobiliary_system0.64870957
166MP0003183_abnormal_peptide_metabolism0.64624142
167MP0000367_abnormal_coat/_hair0.64309308
168MP0000465_gastrointestinal_hemorrhage0.64220229
169MP0005166_decreased_susceptibility_to0.63729921

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.85641003
2Abnormal number of erythroid precursors (HP:0012131)6.69866306
3Reticulocytopenia (HP:0001896)6.12742026
4Pallor (HP:0000980)4.59079337
5Macrocytic anemia (HP:0001972)4.24809019
6Decreased activity of mitochondrial respiratory chain (HP:0008972)4.05519671
7Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.05519671
8Aplastic anemia (HP:0001915)3.93914354
9Hepatocellular necrosis (HP:0001404)3.72523586
10Ragged-red muscle fibers (HP:0003200)3.68927592
11Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.54600734
12Mitochondrial inheritance (HP:0001427)3.53560576
13Congenital malformation of the right heart (HP:0011723)3.51388863
14Double outlet right ventricle (HP:0001719)3.51388863
15Abnormality of the heme biosynthetic pathway (HP:0010472)3.48670324
16Recurrent abscess formation (HP:0002722)3.41589424
17Acute necrotizing encephalopathy (HP:0006965)3.38275722
18Truncus arteriosus (HP:0001660)3.36825456
19Increased hepatocellular lipid droplets (HP:0006565)3.31813254
20Hepatic necrosis (HP:0002605)3.31560495
21Abnormal mitochondria in muscle tissue (HP:0008316)3.26788867
22Increased CSF lactate (HP:0002490)3.26007758
23Aplasia/Hypoplasia of the sacrum (HP:0008517)3.16279220
24Thrombocytosis (HP:0001894)3.14987591
25Elevated erythrocyte sedimentation rate (HP:0003565)3.14593491
26Lipid accumulation in hepatocytes (HP:0006561)3.11985571
27Hyperthyroidism (HP:0000836)3.10684711
28Increased intramyocellular lipid droplets (HP:0012240)3.10316522
29Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.08217563
30Reduced antithrombin III activity (HP:0001976)3.00068665
31Increased serum lactate (HP:0002151)2.99933045
32Exertional dyspnea (HP:0002875)2.97812102
33Multiple enchondromatosis (HP:0005701)2.96577701
34Type I transferrin isoform profile (HP:0003642)2.95503036
35Stridor (HP:0010307)2.95129559
36Petechiae (HP:0000967)2.94195963
37Increased muscle lipid content (HP:0009058)2.86832935
38Abnormality of reticulocytes (HP:0004312)2.86668517
39Myopathic facies (HP:0002058)2.83962340
40Recurrent bacterial skin infections (HP:0005406)2.82064104
41Abnormality of macrophages (HP:0004311)2.81771541
42IgM deficiency (HP:0002850)2.78689625
43Acute encephalopathy (HP:0006846)2.72551501
44Increased serum ferritin (HP:0003281)2.72014035
45Broad distal phalanx of finger (HP:0009836)2.70618600
46Progressive macrocephaly (HP:0004481)2.61789287
47Testicular atrophy (HP:0000029)2.60854915
48Hypertensive crisis (HP:0100735)2.60326389
49Septate vagina (HP:0001153)2.58572219
50Agnosia (HP:0010524)2.58414240
51Poor head control (HP:0002421)2.54760973
52Seborrheic dermatitis (HP:0001051)2.54289683
53Pancytopenia (HP:0001876)2.53464344
54Oral leukoplakia (HP:0002745)2.52932657
55Lactic acidosis (HP:0003128)2.52796263
56Vacuolated lymphocytes (HP:0001922)2.52257834
57Hypokinesia (HP:0002375)2.50730919
58Achilles tendon contracture (HP:0001771)2.49099464
59Exercise intolerance (HP:0003546)2.48957893
60Stomatitis (HP:0010280)2.47994742
61Eczematoid dermatitis (HP:0000976)2.47064116
62Abnormality of the distal phalanges of the toes (HP:0010182)2.45647809
63Unilateral renal agenesis (HP:0000122)2.45438318
64Mediastinal lymphadenopathy (HP:0100721)2.40640890
65Renal Fanconi syndrome (HP:0001994)2.40050457
66Abnormal protein glycosylation (HP:0012346)2.36938527
67Abnormal glycosylation (HP:0012345)2.36938527
68Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.36938527
69Abnormal protein N-linked glycosylation (HP:0012347)2.36938527
70Respiratory difficulties (HP:0002880)2.36718172
713-Methylglutaconic aciduria (HP:0003535)2.34281229
72Prolonged bleeding time (HP:0003010)2.34051012
73Microretrognathia (HP:0000308)2.33771354
74Birth length less than 3rd percentile (HP:0003561)2.33378705
75Abnormal gallbladder physiology (HP:0012438)2.32416290
76Cholecystitis (HP:0001082)2.32416290
77Microvesicular hepatic steatosis (HP:0001414)2.30095572
78Prolonged neonatal jaundice (HP:0006579)2.28634995
79Abnormality of the Achilles tendon (HP:0005109)2.27928586
80Severe visual impairment (HP:0001141)2.25027506
81Respiratory failure (HP:0002878)2.24536400
82Bulbar palsy (HP:0001283)2.24430657
83Gout (HP:0001997)2.21664010
84Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.19688062
85Increased cerebral lipofuscin (HP:0011813)2.18020287
86Nausea (HP:0002018)2.16417373
87Hyperparathyroidism (HP:0000843)2.15882179
88Transposition of the great arteries (HP:0001669)2.14696901
89Abnormal connection of the cardiac segments (HP:0011545)2.14696901
90Abnormal ventriculo-arterial connection (HP:0011563)2.14696901
91Abnormality of aromatic amino acid family metabolism (HP:0004338)2.13661735
92Absent thumb (HP:0009777)2.11204421
93Dicarboxylic aciduria (HP:0003215)2.10030976
94Abnormality of dicarboxylic acid metabolism (HP:0010995)2.10030976
95Abnormality of the anterior horn cell (HP:0006802)2.09945088
96Degeneration of anterior horn cells (HP:0002398)2.09945088
97Breast hypoplasia (HP:0003187)2.08532632
98Pulmonary fibrosis (HP:0002206)2.06427597
99Muscle fiber atrophy (HP:0100295)2.05842026
100Abnormality of the umbilical cord (HP:0010881)2.04642520
101Abnormality of iron homeostasis (HP:0011031)2.04059118
102Abnormality of the gallbladder (HP:0005264)2.03389465
103Abnormality of small intestinal villus morphology (HP:0011472)2.02802740
104Villous atrophy (HP:0011473)2.02802740
105Malnutrition (HP:0004395)2.01500503
106Abnormal hemoglobin (HP:0011902)2.00936791
107Squamous cell carcinoma (HP:0002860)2.00500739
108Trismus (HP:0000211)1.99998634
109Rough bone trabeculation (HP:0100670)1.98584887
110Distal lower limb muscle weakness (HP:0009053)1.97901138
111Increased neuronal autofluorescent lipopigment (HP:0002074)1.97655761
112Progressive muscle weakness (HP:0003323)1.96800415
113Chronic otitis media (HP:0000389)1.96750609
114Abnormality of glutamine family amino acid metabolism (HP:0010902)1.96553538
115Obstructive lung disease (HP:0006536)1.96526377
116Chronic obstructive pulmonary disease (HP:0006510)1.96526377
117Abnormal umbilical cord blood vessels (HP:0011403)1.93593698
118Single umbilical artery (HP:0001195)1.93593698
119Abnormality of the fetal cardiovascular system (HP:0010948)1.93593698
120Cholelithiasis (HP:0001081)1.92464606
121Axonal loss (HP:0003447)1.91447340
122Emotional lability (HP:0000712)1.90453512
123Abnormality of the aortic arch (HP:0012303)1.89548888
124Myelodysplasia (HP:0002863)1.89519141
125Hypoplastic left heart (HP:0004383)1.88217029
126Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.87680131
127Opisthotonus (HP:0002179)1.86621770
128Abnormal trabecular bone morphology (HP:0100671)1.86327677
129Ulnar bowing (HP:0003031)1.86286229
13011 pairs of ribs (HP:0000878)1.84645521
131Abnormality of transition element cation homeostasis (HP:0011030)1.84231129
132Cleft eyelid (HP:0000625)1.84157593
133Abnormality of T cell physiology (HP:0011840)1.83320012
134Lymphoma (HP:0002665)1.82711673
135Recurrent gram-negative bacterial infections (HP:0005420)1.81379764
136Basal ganglia calcification (HP:0002135)1.81033883
137Abnormality of glycolysis (HP:0004366)1.80417600
138Abnormality of glycolipid metabolism (HP:0010969)1.79912565
139Abnormality of liposaccharide metabolism (HP:0010968)1.79912565
140Abnormality of glycosphingolipid metabolism (HP:0004343)1.79912565
141Congenital ichthyosiform erythroderma (HP:0007431)1.79860811
142Thin bony cortex (HP:0002753)1.79807825
143Vertebral compression fractures (HP:0002953)1.78572106
144Cutaneous photosensitivity (HP:0000992)1.78541996
145Selective tooth agenesis (HP:0001592)1.78069169
146Epistaxis (HP:0000421)1.78048746
147Personality changes (HP:0000751)1.76941783
148Abnormality of the tricuspid valve (HP:0001702)1.76891787
149Cerebral edema (HP:0002181)1.76173123
150Myositis (HP:0100614)1.76153237
151Premature ovarian failure (HP:0008209)1.76128009
152Growth hormone excess (HP:0000845)1.75304477
153Abdominal distention (HP:0003270)1.75290677
154Vaginal fistula (HP:0004320)1.75274471
155Abnormality of pyrimidine metabolism (HP:0004353)1.75263246
156Hypergonadotropic hypogonadism (HP:0000815)1.75104159
157Recurrent viral infections (HP:0004429)1.75051498
158Premature graying of hair (HP:0002216)1.74742404
159Abnormal platelet function (HP:0011869)1.74338925
160Impaired platelet aggregation (HP:0003540)1.74338925
161CNS demyelination (HP:0007305)1.73781481
162Type 2 muscle fiber atrophy (HP:0003554)1.73431985
163Rectal prolapse (HP:0002035)1.71365728
164Hypoparathyroidism (HP:0000829)1.71264749
165Nonimmune hydrops fetalis (HP:0001790)1.70960604

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.87533689
2TLK14.52320953
3TRIB34.29051256
4SMG13.38667789
5STK163.28190079
6PIM23.17311658
7WEE12.97793013
8BUB12.66899652
9VRK22.48487493
10EIF2AK32.23442828
11VRK12.19178402
12MAP3K112.15944967
13EIF2AK12.05516582
14SIK11.99287349
15SCYL21.95469504
16ACVR1B1.89821531
17KIT1.87236862
18MAP4K11.81152736
19MST1R1.79708378
20ICK1.66459911
21BLK1.66198071
22SRPK11.63577245
23CDC71.61761209
24TESK21.60974266
25MAP3K121.53781583
26PRPF4B1.53295841
27FLT31.51234165
28TAOK21.45799348
29RPS6KB21.45048609
30KDR1.42561644
31CDK71.42123708
32LRRK21.31993126
33TBK11.31802136
34MATK1.30446419
35TAOK11.26800754
36CDK191.26700976
37DYRK31.23073956
38BTK1.23072839
39TEC1.21923886
40BCKDK1.21127249
41ABL21.18041061
42PIM11.15697261
43PRKG21.14943800
44TYK21.13784410
45IRAK41.11107873
46ZAP701.07998385
47IRAK31.05982408
48IRAK21.03850786
49BRSK21.03849806
50MAPK111.03475944
51PRKD31.03315009
52JAK31.03128457
53MAP3K81.00505984
54IKBKB0.99376599
55ERN10.99033185
56MAP3K10.98949145
57PRKCI0.98711184
58RPS6KA40.97781612
59TGFBR10.97414310
60TSSK60.97219514
61NME10.95855984
62SYK0.95329408
63MAPKAPK30.95270559
64DAPK30.94820285
65LMTK20.94754819
66CSNK1G30.93250238
67MAP2K20.92551830
68PLK10.91395959
69MAP3K30.90095106
70MAP2K60.87925005
71ATR0.87502324
72PKN20.85497035
73CSF1R0.84778690
74EIF2AK20.82838654
75PDPK10.82484268
76ARAF0.82367146
77PBK0.80724307
78ILK0.79119346
79PAK40.78559905
80AURKA0.78245203
81LYN0.77483498
82CDK80.76170840
83TESK10.75735933
84ADRBK20.75205932
85FES0.73019920
86PTK60.72425960
87RPS6KA20.71388892
88MKNK10.71289568
89STK100.70153273
90AURKB0.69125250
91GRK60.68770851
92RIPK40.68151316
93MAP3K100.66809933
94MUSK0.66445766
95PLK40.65001524
96LIMK10.64186215
97CSNK1A1L0.64006216
98NEK20.62880580
99PRKD20.62375670
100MKNK20.61498551
101CDK40.60972259
102PAK10.60792636
103TAF10.60242994
104CDK120.59225860
105RPS6KL10.58701661
106RPS6KC10.58701661
107AKT20.58644638
108LCK0.58052691
109TXK0.57826981
110CSNK2A10.57415542
111MAP2K70.57409945
112TTN0.56961810
113RAF10.56947822
114CSNK2A20.56739824
115DAPK10.56303832
116MAPK120.55963762
117MAP2K30.55829953
118STK40.55152426
119PDK20.54720239
120BRSK10.54342349
121EPHA20.54244180
122BRAF0.54036038
123CAMK2G0.53830132
124BMX0.50772890
125HIPK20.48721940
126IKBKE0.46750393
127YES10.45220846
128MAPK40.45135423
129RPS6KA60.42603678
130CHEK20.41992881
131MTOR0.41003739
132CSNK1G10.40757560
133TGFBR20.39861239
134PRKCD0.39315744
135FGFR40.38828625
136TNK20.38190471
137PTK20.36898488
138PHKG10.36621181
139PHKG20.36621181
140CSNK1G20.34801510
141RPS6KA50.34161452
142MOS0.33935758
143MAP3K60.33608196
144GRK70.33231816
145CDK90.31702355
146TNIK0.31208300
147EEF2K0.31119938
148PDK10.30390576
149CDC42BPA0.30168428
150TAOK30.29645858
151RIPK10.29600549
152MAPKAPK20.28356093

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.04368936
2DNA replication_Homo sapiens_hsa030304.31658673
3Proteasome_Homo sapiens_hsa030503.35100292
4Mismatch repair_Homo sapiens_hsa034303.25119399
5Sulfur metabolism_Homo sapiens_hsa009203.03634575
6RNA polymerase_Homo sapiens_hsa030202.90924759
7Oxidative phosphorylation_Homo sapiens_hsa001902.67219822
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.63272122
9Pyrimidine metabolism_Homo sapiens_hsa002402.58921229
10Parkinsons disease_Homo sapiens_hsa050122.52656085
11Base excision repair_Homo sapiens_hsa034102.48710292
12Spliceosome_Homo sapiens_hsa030402.44063847
13Homologous recombination_Homo sapiens_hsa034402.34695335
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.09383172
15Nucleotide excision repair_Homo sapiens_hsa034202.06675367
16One carbon pool by folate_Homo sapiens_hsa006701.87241320
17Huntingtons disease_Homo sapiens_hsa050161.84071614
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81553747
19RNA transport_Homo sapiens_hsa030131.68868623
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.59166307
21Phenylalanine metabolism_Homo sapiens_hsa003601.53641973
22Alzheimers disease_Homo sapiens_hsa050101.52964110
23Fat digestion and absorption_Homo sapiens_hsa049751.51158026
24Sulfur relay system_Homo sapiens_hsa041221.50760771
25Protein export_Homo sapiens_hsa030601.46118704
26Arginine biosynthesis_Homo sapiens_hsa002201.45341858
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.41668674
28Vitamin B6 metabolism_Homo sapiens_hsa007501.40056496
29Arginine and proline metabolism_Homo sapiens_hsa003301.37562501
30Folate biosynthesis_Homo sapiens_hsa007901.31406680
31Vibrio cholerae infection_Homo sapiens_hsa051101.29018297
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.28509638
33Bladder cancer_Homo sapiens_hsa052191.27001807
34Fanconi anemia pathway_Homo sapiens_hsa034601.22063030
35Cell cycle_Homo sapiens_hsa041101.15184302
36Purine metabolism_Homo sapiens_hsa002301.14908877
37RNA degradation_Homo sapiens_hsa030181.13139076
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10808849
39Vitamin digestion and absorption_Homo sapiens_hsa049771.09750601
40Legionellosis_Homo sapiens_hsa051341.08372808
41Non-homologous end-joining_Homo sapiens_hsa034501.08059777
42Other glycan degradation_Homo sapiens_hsa005111.07836556
43Pentose phosphate pathway_Homo sapiens_hsa000301.07178191
44Caffeine metabolism_Homo sapiens_hsa002321.06888605
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05644859
46Fatty acid elongation_Homo sapiens_hsa000621.00000720
47Herpes simplex infection_Homo sapiens_hsa051680.99338109
48Leishmaniasis_Homo sapiens_hsa051400.96514797
49p53 signaling pathway_Homo sapiens_hsa041150.91929834
50Antigen processing and presentation_Homo sapiens_hsa046120.91212379
51Basal transcription factors_Homo sapiens_hsa030220.89139678
52Epstein-Barr virus infection_Homo sapiens_hsa051690.88157695
53Notch signaling pathway_Homo sapiens_hsa043300.85858011
54Systemic lupus erythematosus_Homo sapiens_hsa053220.85840397
55N-Glycan biosynthesis_Homo sapiens_hsa005100.82673917
56Collecting duct acid secretion_Homo sapiens_hsa049660.82200712
57Galactose metabolism_Homo sapiens_hsa000520.81278012
58Primary immunodeficiency_Homo sapiens_hsa053400.80319814
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78627490
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.78307833
61Hematopoietic cell lineage_Homo sapiens_hsa046400.73786174
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73724974
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72996366
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.72134089
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71763471
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70326474
67Apoptosis_Homo sapiens_hsa042100.68827018
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.68430340
69Pyruvate metabolism_Homo sapiens_hsa006200.67819374
70Glutathione metabolism_Homo sapiens_hsa004800.66865587
71Measles_Homo sapiens_hsa051620.66720902
72Alcoholism_Homo sapiens_hsa050340.66083051
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65503212
74Biosynthesis of amino acids_Homo sapiens_hsa012300.63693462
75Malaria_Homo sapiens_hsa051440.62803705
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.62473478
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62454470
78Tyrosine metabolism_Homo sapiens_hsa003500.61442286
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61256851
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61093174
81Asthma_Homo sapiens_hsa053100.60280264
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.60079795
83Thyroid cancer_Homo sapiens_hsa052160.59976938
84Shigellosis_Homo sapiens_hsa051310.59291266
85Renin-angiotensin system_Homo sapiens_hsa046140.57892217
86Acute myeloid leukemia_Homo sapiens_hsa052210.55597019
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55223360
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.54269206
89Tuberculosis_Homo sapiens_hsa051520.53322831
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.52335676
91Cardiac muscle contraction_Homo sapiens_hsa042600.52123875
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51824311
93Influenza A_Homo sapiens_hsa051640.50751947
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50417177
95VEGF signaling pathway_Homo sapiens_hsa043700.50331423
96Fructose and mannose metabolism_Homo sapiens_hsa000510.49628535
97Carbon metabolism_Homo sapiens_hsa012000.49388947
98Sphingolipid metabolism_Homo sapiens_hsa006000.49263302
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47375972
100Metabolic pathways_Homo sapiens_hsa011000.46940944
101Prion diseases_Homo sapiens_hsa050200.45802515
102Pertussis_Homo sapiens_hsa051330.45530913
103Non-small cell lung cancer_Homo sapiens_hsa052230.45289667
104Insulin signaling pathway_Homo sapiens_hsa049100.45262699
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44884073
106Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44577932
107Lysosome_Homo sapiens_hsa041420.44257175
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43876122
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43123362
110Salmonella infection_Homo sapiens_hsa051320.42967243
111mRNA surveillance pathway_Homo sapiens_hsa030150.41881026
112Phagosome_Homo sapiens_hsa041450.41628526
113Viral carcinogenesis_Homo sapiens_hsa052030.41342511
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41245946
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40212247
116B cell receptor signaling pathway_Homo sapiens_hsa046620.38874409
117Hepatitis C_Homo sapiens_hsa051600.38413018
118Rheumatoid arthritis_Homo sapiens_hsa053230.37564074
119Glycosaminoglycan degradation_Homo sapiens_hsa005310.37441197
120Allograft rejection_Homo sapiens_hsa053300.36730649
121Hepatitis B_Homo sapiens_hsa051610.36004480
122Osteoclast differentiation_Homo sapiens_hsa043800.35085067
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34381175
124Selenocompound metabolism_Homo sapiens_hsa004500.34147935
125Chronic myeloid leukemia_Homo sapiens_hsa052200.33054318
126Graft-versus-host disease_Homo sapiens_hsa053320.32510454
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32001798
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30998501
129Fatty acid metabolism_Homo sapiens_hsa012120.30377725
130AMPK signaling pathway_Homo sapiens_hsa041520.30188582
131Jak-STAT signaling pathway_Homo sapiens_hsa046300.30065574
132Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.29897736
133Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29793615
134Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29671544
135Fatty acid degradation_Homo sapiens_hsa000710.29653891
136Starch and sucrose metabolism_Homo sapiens_hsa005000.28715452
137Arachidonic acid metabolism_Homo sapiens_hsa005900.27466408
138Synaptic vesicle cycle_Homo sapiens_hsa047210.27142280
139Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24918082
140Pancreatic cancer_Homo sapiens_hsa052120.23139493
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.22447455
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.20574675
143HTLV-I infection_Homo sapiens_hsa051660.19171029

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