COPB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein subunit of the coatomer complex associated with non-clathrin coated vesicles. The coatomer complex, also known as the coat protein complex 1, forms in the cytoplasm and is recruited to the Golgi by activated guanosine triphosphatases. Once at the Golgi membrane, the coatomer complex may assist in the movement of protein and lipid components back to the endoplasmic reticulum. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* Golgi transport vesicle coating (GO:0048200)9.36420723
2* COPI coating of Golgi vesicle (GO:0048205)9.36420723
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.78494994
4COPII vesicle coating (GO:0048208)6.36638594
5protein retention in ER lumen (GO:0006621)5.88814969
6signal peptide processing (GO:0006465)5.35041882
7* retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.90553435
8nuclear pore complex assembly (GO:0051292)4.83297818
9activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.52597641
10positive regulation of nuclease activity (GO:0032075)4.34247630
11nuclear pore organization (GO:0006999)4.33573524
12endoplasmic reticulum unfolded protein response (GO:0030968)4.13775591
13* vesicle coating (GO:0006901)4.11264561
14cellular response to unfolded protein (GO:0034620)4.04588296
15regulation of nuclease activity (GO:0032069)4.03381004
16exocrine pancreas development (GO:0031017)4.01619172
17sequestering of metal ion (GO:0051238)4.00459536
18ribosome assembly (GO:0042255)3.99623956
19regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.95077423
20ER overload response (GO:0006983)3.89255969
21ER-nucleus signaling pathway (GO:0006984)3.88989760
22mitotic sister chromatid cohesion (GO:0007064)3.87851809
23cell adhesion mediated by integrin (GO:0033627)3.83445464
24cellular response to topologically incorrect protein (GO:0035967)3.83026044
25endocrine pancreas development (GO:0031018)3.69904332
26cellular response to vitamin D (GO:0071305)3.60826670
27peptide catabolic process (GO:0043171)3.60256485
28protein maturation by protein folding (GO:0022417)3.57263557
294-hydroxyproline metabolic process (GO:0019471)3.41464507
30non-recombinational repair (GO:0000726)3.41056711
31double-strand break repair via nonhomologous end joining (GO:0006303)3.41056711
32pore complex assembly (GO:0046931)3.40881070
33mitotic metaphase plate congression (GO:0007080)3.40177585
34mitotic sister chromatid segregation (GO:0000070)3.37926023
35metaphase plate congression (GO:0051310)3.37548432
36sister chromatid segregation (GO:0000819)3.37215539
37response to endoplasmic reticulum stress (GO:0034976)3.34008470
38keratan sulfate catabolic process (GO:0042340)3.31439077
39proteasome assembly (GO:0043248)3.30799108
40ER to Golgi vesicle-mediated transport (GO:0006888)3.30074187
41regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.23548101
42establishment of chromosome localization (GO:0051303)3.21498607
43type B pancreatic cell development (GO:0003323)3.20173949
44UDP-N-acetylglucosamine metabolic process (GO:0006047)3.19535341
45peptide hormone processing (GO:0016486)3.18863023
46peptidyl-glutamic acid carboxylation (GO:0017187)3.17087586
47protein carboxylation (GO:0018214)3.17087586
48tRNA aminoacylation for protein translation (GO:0006418)3.12547154
49protein N-linked glycosylation via asparagine (GO:0018279)3.11616405
50intestinal cholesterol absorption (GO:0030299)3.09489582
51peptidyl-asparagine modification (GO:0018196)3.08440309
52ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.07989771
53response to unfolded protein (GO:0006986)3.07627788
54tRNA aminoacylation (GO:0043039)3.06758662
55amino acid activation (GO:0043038)3.06758662
56retina vasculature morphogenesis in camera-type eye (GO:0061299)2.99709843
57folic acid-containing compound biosynthetic process (GO:0009396)2.97620207
58regulation of mitotic spindle organization (GO:0060236)2.97598279
59intestinal absorption (GO:0050892)2.97197983
60response to topologically incorrect protein (GO:0035966)2.96486219
61regulation of centriole replication (GO:0046599)2.94515556
62positive regulation of protein autophosphorylation (GO:0031954)2.93491619
63collagen fibril organization (GO:0030199)2.90098737
64cellular response to vitamin (GO:0071295)2.89666859
65regulation of hexokinase activity (GO:1903299)2.85523782
66regulation of glucokinase activity (GO:0033131)2.85523782
67valine metabolic process (GO:0006573)2.83591427
68protein localization to kinetochore (GO:0034501)2.83418473
69protein N-linked glycosylation (GO:0006487)2.82241476
70spindle checkpoint (GO:0031577)2.81744405
71ventricular cardiac muscle cell development (GO:0055015)2.80859115
72hormone catabolic process (GO:0042447)2.78057605
73response to X-ray (GO:0010165)2.77950569
74regulation of DNA endoreduplication (GO:0032875)2.76386666
75L-phenylalanine catabolic process (GO:0006559)2.72675555
76erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.72675555
77mitotic nuclear envelope disassembly (GO:0007077)2.72367867
78regulation of transforming growth factor beta2 production (GO:0032909)2.71803609
79glandular epithelial cell development (GO:0002068)2.70606370
80cullin deneddylation (GO:0010388)2.70444801
81sequestering of extracellular ligand from receptor (GO:0035581)2.69585564
82regulation of sister chromatid cohesion (GO:0007063)2.68329856
83attachment of spindle microtubules to kinetochore (GO:0008608)2.66417137
84regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.65141323
85mitotic spindle checkpoint (GO:0071174)2.63891880
86zinc ion transport (GO:0006829)2.62998022
87protein localization to chromosome, centromeric region (GO:0071459)2.62476456
88keratinocyte development (GO:0003334)2.59954558
89positive regulation of glycolytic process (GO:0045821)2.59745973
90establishment of integrated proviral latency (GO:0075713)2.58905642
91membrane disassembly (GO:0030397)2.58714467
92nuclear envelope disassembly (GO:0051081)2.58714467
93protein heterotetramerization (GO:0051290)2.57921288
94glandular epithelial cell differentiation (GO:0002067)2.57822618
95regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.57489375
96positive regulation of hormone biosynthetic process (GO:0046886)2.55808766
97regulation of type B pancreatic cell apoptotic process (GO:2000674)2.55278612
98Golgi organization (GO:0007030)2.54106895
99DNA ligation (GO:0006266)2.53645101
100lactate metabolic process (GO:0006089)2.50652824
101regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.50608745
102spindle assembly involved in mitosis (GO:0090307)2.49642182
103regulation of chromosome segregation (GO:0051983)2.49612791
104female gonad development (GO:0008585)2.49051149
105meiotic chromosome segregation (GO:0045132)2.48871730
106growth hormone receptor signaling pathway (GO:0060396)2.48430617
107membrane budding (GO:0006900)2.47718484
108regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.47559445
109regulation of metalloenzyme activity (GO:0048552)2.45972550
110protein autoprocessing (GO:0016540)2.45613390
111positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.45310320
112DNA double-strand break processing (GO:0000729)2.44705054
113mitotic spindle organization (GO:0007052)2.44313882
114cellular zinc ion homeostasis (GO:0006882)2.43837825
115CENP-A containing nucleosome assembly (GO:0034080)2.43116368
116tricarboxylic acid cycle (GO:0006099)2.43050714
117nucleotide transmembrane transport (GO:1901679)2.42762819
118nucleotide-sugar biosynthetic process (GO:0009226)2.42462819
119regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.41637882
120regulation of mitotic metaphase/anaphase transition (GO:0030071)2.41637882
121anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.39785247
122kinetochore organization (GO:0051383)2.39447040
123protein deneddylation (GO:0000338)2.38827923
124embryonic foregut morphogenesis (GO:0048617)2.38248151
125regulation of spindle organization (GO:0090224)2.38199908
126regulation of cofactor metabolic process (GO:0051193)2.38061707
127regulation of coenzyme metabolic process (GO:0051196)2.38061707
128positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.37243334
129positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.37243334
130positive regulation of mitotic sister chromatid separation (GO:1901970)2.37243334
131wound healing, spreading of epidermal cells (GO:0035313)2.37057743
132negative regulation of glycoprotein biosynthetic process (GO:0010561)2.36765873
133sister chromatid cohesion (GO:0007062)2.36085299
134antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.35013521
135antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.35013521
136regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.34483196
137positive regulation of glycoprotein metabolic process (GO:1903020)2.34115949
138lipoprotein metabolic process (GO:0042157)2.32940722
139negative regulation of chondrocyte differentiation (GO:0032331)2.32929917
140spindle assembly checkpoint (GO:0071173)2.32576440
141regulation of sulfur metabolic process (GO:0042762)2.32183256
142negative regulation of keratinocyte proliferation (GO:0010839)2.31342314
143anterior/posterior axis specification, embryo (GO:0008595)2.31279591
144branched-chain amino acid catabolic process (GO:0009083)2.30275685
145microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.30137589
146chondrocyte development (GO:0002063)2.29952079
147mitotic spindle assembly checkpoint (GO:0007094)2.29656700
148columnar/cuboidal epithelial cell development (GO:0002066)2.29241136
149resolution of meiotic recombination intermediates (GO:0000712)2.29197442
150lipid particle organization (GO:0034389)2.29094113
151alpha-linolenic acid metabolic process (GO:0036109)2.29067395
152lung vasculature development (GO:0060426)2.28972721
153erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.27485378
154L-phenylalanine metabolic process (GO:0006558)2.27485378
155transcytosis (GO:0045056)2.27285328
156apoptotic cell clearance (GO:0043277)2.26872629
157regulation of translation in response to stress (GO:0043555)2.25903766
158regulation of mitotic sister chromatid segregation (GO:0033047)2.25424448
159zinc ion homeostasis (GO:0055069)2.24834179
160positive regulation of receptor biosynthetic process (GO:0010870)2.24574797
161negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.24243459
162tetrahydrofolate metabolic process (GO:0046653)2.22725404
163response to hepatocyte growth factor (GO:0035728)2.21710594
164cellular response to hepatocyte growth factor stimulus (GO:0035729)2.21710594
165regulation of cholesterol homeostasis (GO:2000188)2.21674692
166reverse cholesterol transport (GO:0043691)2.19635161
167homocysteine metabolic process (GO:0050667)2.18933648
168skin morphogenesis (GO:0043589)2.17587033
169sulfur amino acid catabolic process (GO:0000098)2.16368483
170negative regulation of fatty acid transport (GO:2000192)2.16085099
171negative regulation of fibrinolysis (GO:0051918)2.15560054
172tricarboxylic acid metabolic process (GO:0072350)2.15228352
173cellular response to growth hormone stimulus (GO:0071378)2.14557453
174cellular response to nutrient (GO:0031670)2.13320337
175purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.11636346
1763-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.11636346
177aromatic amino acid family catabolic process (GO:0009074)2.10278645
178regulation of extracellular matrix disassembly (GO:0010715)2.10228370
179regulation of receptor biosynthetic process (GO:0010869)2.10179415
180gland morphogenesis (GO:0022612)2.10082626
181negative regulation of glycogen biosynthetic process (GO:0045719)2.09735114
182high-density lipoprotein particle remodeling (GO:0034375)2.09671697
183maintenance of protein localization in organelle (GO:0072595)2.09339269
184tyrosine metabolic process (GO:0006570)2.07672187

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human4.25316913
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.86085215
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.79679552
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.45566412
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.34544866
6CLOCK_20551151_ChIP-Seq_293T_Human3.32326661
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.05203403
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.01730864
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.99136398
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.87847590
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.77819317
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.72273427
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.63935223
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.45358054
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.30682064
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.28797581
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.18205086
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.14693206
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14535314
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12143639
21PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.10279938
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.08962510
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.07749066
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.06203157
25WT1_19549856_ChIP-ChIP_CCG9911_Human1.98152167
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.96947083
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.93657629
28CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.87764184
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.86989888
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.82681090
31SALL4_18804426_ChIP-ChIP_XEN_Mouse1.82272336
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81060168
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.78262489
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76504861
35DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.76134647
36DCP1A_22483619_ChIP-Seq_HELA_Human1.71980603
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67660005
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.67537444
39SOX2_27498859_Chip-Seq_STOMACH_Mouse1.66334622
40ELK1_19687146_ChIP-ChIP_HELA_Human1.64692394
41SOX2_20726797_ChIP-Seq_SW620_Human1.63884709
42CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.63389184
43HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.58126217
44CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.57661695
45* FUS_26573619_Chip-Seq_HEK293_Human1.57122074
46SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.56816602
47BRD4_25478319_ChIP-Seq_HGPS_Human1.55822039
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.55403238
49EWS_26573619_Chip-Seq_HEK293_Human1.54621515
50* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51185066
51* VDR_23849224_ChIP-Seq_CD4+_Human1.48042121
52GATA4_25053715_ChIP-Seq_YYC3_Human1.47849456
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.47267475
54TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46714894
55CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.44841388
56AR_21909140_ChIP-Seq_LNCAP_Human1.44534416
57NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.43347007
58FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.43227226
59TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.42849579
60RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.40918844
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.39774390
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.38499072
63FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38140248
64NRF2_20460467_ChIP-Seq_MEFs_Mouse1.37981690
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.37981690
66TFEB_21752829_ChIP-Seq_HELA_Human1.36580368
67CJUN_26792858_Chip-Seq_BT549_Human1.34433382
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.33868450
69SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.33559632
70SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.33559632
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33530948
72HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33211699
73STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.29966316
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28260080
75RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28099945
76PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26935030
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26213899
78NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25063758
79ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24973731
80FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.24818282
81MYC_18555785_ChIP-Seq_MESCs_Mouse1.24335008
82HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24238932
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21413998
84E2F1_21310950_ChIP-Seq_MCF-7_Human1.20351591
85GABP_17652178_ChIP-ChIP_JURKAT_Human1.20126124
86NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.19660314
87SALL1_21062744_ChIP-ChIP_HESCs_Human1.18803196
88ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18625766
89GATA3_24758297_ChIP-Seq_MCF-7_Human1.17723856
90MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17414997
91IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17232464
92CHD1_26751641_Chip-Seq_LNCaP_Human1.17192311
93FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16539459
94FOXO3_23340844_ChIP-Seq_DLD1_Human1.15317352
95E2F1_18555785_ChIP-Seq_MESCs_Mouse1.14987644
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14911864
97NELFA_20434984_ChIP-Seq_ESCs_Mouse1.13328517
98JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11704811
99Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11295257
100* FOXP3_21729870_ChIP-Seq_TREG_Human1.10799626
101ETS1_20019798_ChIP-Seq_JURKAT_Human1.10446728
102GATA6_25053715_ChIP-Seq_YYC3_Human1.09747709
103ZNF274_21170338_ChIP-Seq_K562_Hela1.08948940
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08761431
105BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08519886
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08039330
107* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07396343
108GABP_19822575_ChIP-Seq_HepG2_Human1.06980226
109FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06946059
110P300_19829295_ChIP-Seq_ESCs_Human1.06858972
111EZH2_27294783_Chip-Seq_NPCs_Mouse1.06487151
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04714165
113GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04575557
114SRF_21415370_ChIP-Seq_HL-1_Mouse1.02462248
115FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.02013514
116SOX17_20123909_ChIP-Seq_XEN_Mouse1.01004870
117TAF15_26573619_Chip-Seq_HEK293_Human1.00827980
118AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00647451
119NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00555944
120ELF5_23300383_ChIP-Seq_T47D_Human1.00321971
121PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00102062
122MYB_21317192_ChIP-Seq_ERMYB_Mouse0.99942204
123* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98916919
124FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.98645934
125CDX2_22108803_ChIP-Seq_LS180_Human0.98202784
126UBF1/2_26484160_Chip-Seq_HMECs_Human0.98123655
127KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.97305950
128* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96305520
129SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95840508
130RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95067560
131ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95059874
132HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94922753
133EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94789757
134E2F7_22180533_ChIP-Seq_HELA_Human0.94714899
135ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93226298
136NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93158078
137CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92971014
138NANOG_16153702_ChIP-ChIP_HESCs_Human0.92760039
139SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92187754
140EOMES_21245162_ChIP-Seq_HESCs_Human0.91937395
141IRF8_21731497_ChIP-ChIP_J774_Mouse0.91808762
142TP53_18474530_ChIP-ChIP_U2OS_Human0.91725358
143ELK1_22589737_ChIP-Seq_MCF10A_Human0.91407796
144ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91345439
145ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90953906
146TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90790354
147HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.90284590
148PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90069650
149FOXA2_19822575_ChIP-Seq_HepG2_Human0.89426889
150TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89104232
151NANOG_18555785_Chip-Seq_ESCs_Mouse0.88610720
152ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87703415
153FOXA1_25552417_ChIP-Seq_VCAP_Human0.87637616
154ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87551710
155JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87324794
156ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85648665

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.66575621
2MP0002877_abnormal_melanocyte_morpholog3.46007662
3MP0002139_abnormal_hepatobiliary_system2.92203455
4MP0003950_abnormal_plasma_membrane2.92123759
5MP0006054_spinal_hemorrhage2.78745481
6MP0003705_abnormal_hypodermis_morpholog2.56879184
7MP0003941_abnormal_skin_development2.48381181
8MP0004957_abnormal_blastocyst_morpholog2.39124069
9MP0005365_abnormal_bile_salt2.39004104
10MP0010094_abnormal_chromosome_stability2.29968493
11MP0005503_abnormal_tendon_morphology2.25057656
12MP0003195_calcinosis2.22176748
13MP0005275_abnormal_skin_tensile2.11811505
14MP0008057_abnormal_DNA_replication2.09397142
15MP0005360_urolithiasis2.05180048
16MP0005220_abnormal_exocrine_pancreas2.03559557
17MP0003252_abnormal_bile_duct1.97913365
18MP0009780_abnormal_chondrocyte_physiolo1.96045540
19MP0004264_abnormal_extraembryonic_tissu1.86844928
20MP0003300_gastrointestinal_ulcer1.85864610
21MP0005085_abnormal_gallbladder_physiolo1.84183672
22MP0003806_abnormal_nucleotide_metabolis1.73737167
23MP0003693_abnormal_embryo_hatching1.73602013
24MP0003283_abnormal_digestive_organ1.73196930
25MP0004272_abnormal_basement_membrane1.72813666
26MP0010352_gastrointestinal_tract_polyps1.70251746
27MP0002138_abnormal_hepatobiliary_system1.69138839
28MP0002693_abnormal_pancreas_physiology1.67210051
29MP0008058_abnormal_DNA_repair1.65489563
30MP0001944_abnormal_pancreas_morphology1.65363529
31MP0002896_abnormal_bone_mineralization1.62259743
32MP0003077_abnormal_cell_cycle1.60306550
33MP0002102_abnormal_ear_morphology1.55922056
34MP0010234_abnormal_vibrissa_follicle1.55159341
35MP0003890_abnormal_embryonic-extraembry1.54639702
36MP0008932_abnormal_embryonic_tissue1.54489500
37MP0000013_abnormal_adipose_tissue1.52689922
38MP0005408_hypopigmentation1.51719184
39MP0000372_irregular_coat_pigmentation1.50843229
40MP0003566_abnormal_cell_adhesion1.49336645
41MP0009384_cardiac_valve_regurgitation1.48547636
42MP0001666_abnormal_nutrient_absorption1.47725746
43MP0003111_abnormal_nucleus_morphology1.46139659
44MP0003183_abnormal_peptide_metabolism1.39750434
45MP0010386_abnormal_urinary_bladder1.37373259
46MP0003718_maternal_effect1.34716788
47MP0009053_abnormal_anal_canal1.34595828
48MP0002060_abnormal_skin_morphology1.33185701
49MP0000678_abnormal_parathyroid_gland1.30951799
50MP0002084_abnormal_developmental_patter1.30563119
51MP0000647_abnormal_sebaceous_gland1.29899067
52MP0001697_abnormal_embryo_size1.27963885
53MP0005023_abnormal_wound_healing1.26547916
54MP0003385_abnormal_body_wall1.26079339
55MP0010678_abnormal_skin_adnexa1.25621290
56MP0000516_abnormal_urinary_system1.25425494
57MP0005367_renal/urinary_system_phenotyp1.25425494
58MP0001672_abnormal_embryogenesis/_devel1.24937888
59MP0005380_embryogenesis_phenotype1.24937888
60MP0005076_abnormal_cell_differentiation1.24705490
61MP0010030_abnormal_orbit_morphology1.23390523
62MP0003984_embryonic_growth_retardation1.22266703
63MP0002088_abnormal_embryonic_growth/wei1.19460416
64MP0009643_abnormal_urine_homeostasis1.18628340
65MP0001915_intracranial_hemorrhage1.18234474
66MP0001243_abnormal_dermal_layer1.14352299
67MP0005623_abnormal_meninges_morphology1.13055803
68MP0003786_premature_aging1.13053827
69MP0001730_embryonic_growth_arrest1.11282809
70MP0000163_abnormal_cartilage_morphology1.10329337
71MP0000569_abnormal_digit_pigmentation1.09033310
72MP0002090_abnormal_vision1.08727510
73MP0005508_abnormal_skeleton_morphology1.08599224
74MP0002295_abnormal_pulmonary_circulatio1.08063363
75MP0002933_joint_inflammation1.07906009
76MP0002086_abnormal_extraembryonic_tissu1.07373381
77MP0003279_aneurysm1.07162873
78MP0003795_abnormal_bone_structure1.05829517
79MP0005395_other_phenotype1.03462076
80MP0008877_abnormal_DNA_methylation1.03265724
81MP0003123_paternal_imprinting1.02934345
82MP0008875_abnormal_xenobiotic_pharmacok1.01490541
83MP0005187_abnormal_penis_morphology1.01394318
84MP0004043_abnormal_pH_regulation1.00760892
85MP0002115_abnormal_skeleton_extremities1.00251551
86MP0000427_abnormal_hair_cycle0.98653833
87MP0002928_abnormal_bile_duct0.98062904
88MP0003937_abnormal_limbs/digits/tail_de0.98031994
89MP0004782_abnormal_surfactant_physiolog0.97588180
90MP0001533_abnormal_skeleton_physiology0.97387050
91MP0001542_abnormal_bone_strength0.97068271
92MP0009697_abnormal_copulation0.96293376
93MP0010329_abnormal_lipoprotein_level0.96020249
94MP0000358_abnormal_cell_content/0.95493661
95MP0000609_abnormal_liver_physiology0.95364240
96MP0002006_tumorigenesis0.94234742
97MP0003755_abnormal_palate_morphology0.93796106
98MP0010368_abnormal_lymphatic_system0.93754038
99MP0002233_abnormal_nose_morphology0.93579262
100MP0000350_abnormal_cell_proliferation0.93412961
101MP0003221_abnormal_cardiomyocyte_apopto0.92625252
102MP0003186_abnormal_redox_activity0.91016829
103MP0005257_abnormal_intraocular_pressure0.90989219
104MP0005379_endocrine/exocrine_gland_phen0.90869680
105MP0003868_abnormal_feces_composition0.90658833
106MP0002080_prenatal_lethality0.90652338
107MP0005390_skeleton_phenotype0.89787751
108MP0002085_abnormal_embryonic_tissue0.89438105
109MP0002166_altered_tumor_susceptibility0.89401091
110MP0002078_abnormal_glucose_homeostasis0.88586257
111MP0005171_absent_coat_pigmentation0.88220712
112MP0000003_abnormal_adipose_tissue0.86874686
113MP0001756_abnormal_urination0.86321435
114MP0002938_white_spotting0.85575563
115MP0005058_abnormal_lysosome_morphology0.85328728
116MP0005248_abnormal_Harderian_gland0.85276495
117MP0003315_abnormal_perineum_morphology0.85216926
118MP0009840_abnormal_foam_cell0.84729368
119MP0005083_abnormal_biliary_tract0.83982829
120MP0002168_other_aberrant_phenotype0.83632235
121MP0005197_abnormal_uvea_morphology0.83272664
122MP0003091_abnormal_cell_migration0.82714337
123MP0002254_reproductive_system_inflammat0.82566398
124MP0000598_abnormal_liver_morphology0.82425287
125MP0010307_abnormal_tumor_latency0.82331015
126MP0000613_abnormal_salivary_gland0.82296999
127MP0006072_abnormal_retinal_apoptosis0.82018101
128MP0002113_abnormal_skeleton_development0.81391092
129MP0009703_decreased_birth_body0.78928990
130MP0002998_abnormal_bone_remodeling0.78843102
131MP0005084_abnormal_gallbladder_morpholo0.77563944
132MP0002177_abnormal_outer_ear0.77193351
133MP0001216_abnormal_epidermal_layer0.75215145
134MP0005384_cellular_phenotype0.74642684
135MP0008007_abnormal_cellular_replicative0.74455820
136MP0004134_abnormal_chest_morphology0.74116996
137MP0005621_abnormal_cell_physiology0.73970882
138MP0004197_abnormal_fetal_growth/weight/0.73888622
139MP0003935_abnormal_craniofacial_develop0.73516023
140MP0002009_preneoplasia0.73445436
141MP0001879_abnormal_lymphatic_vessel0.72703451
142MP0005332_abnormal_amino_acid0.72693106
143MP0004233_abnormal_muscle_weight0.72100077
144MP0003191_abnormal_cellular_cholesterol0.72078078
145MP0003436_decreased_susceptibility_to0.71271951
146MP0000371_diluted_coat_color0.70000253
147MP0001191_abnormal_skin_condition0.69767649
148MP0000538_abnormal_urinary_bladder0.69612067
149MP0005319_abnormal_enzyme/_coenzyme0.69486376
150MP0000537_abnormal_urethra_morphology0.69007290
151MP0002909_abnormal_adrenal_gland0.68605214
152MP0000767_abnormal_smooth_muscle0.68509902
153MP0001849_ear_inflammation0.68250569
154MP0001881_abnormal_mammary_gland0.68200578
155MP0001299_abnormal_eye_distance/0.66607360
156MP0003942_abnormal_urinary_system0.65565206
157MP0003959_abnormal_lean_body0.65063830
158MP0003943_abnormal_hepatobiliary_system0.64906409
159MP0002118_abnormal_lipid_homeostasis0.63759599
160MP0004019_abnormal_vitamin_homeostasis0.62933116

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.42607005
2Hypoglycemic seizures (HP:0002173)4.16527446
3Cervical subluxation (HP:0003308)3.84691664
4Hyperinsulinemic hypoglycemia (HP:0000825)3.73897391
5Symptomatic seizures (HP:0011145)3.68671337
6Abnormality of the intrinsic pathway (HP:0010989)3.46175932
7Hyperglycemia (HP:0003074)3.25073597
8Pancreatic islet-cell hyperplasia (HP:0004510)3.24086598
9Abnormal foot bone ossification (HP:0010675)3.07841857
10Abnormality of the common coagulation pathway (HP:0010990)3.07327918
11Abnormality of endocrine pancreas physiology (HP:0012093)3.07287633
12Abnormality of the pancreatic islet cells (HP:0006476)3.07287633
13Epiphyseal dysplasia (HP:0002656)3.06088872
14Abnormality of glycolysis (HP:0004366)3.02871653
15Protrusio acetabuli (HP:0003179)2.99515895
16Increased serum pyruvate (HP:0003542)2.98909224
17Abnormal pancreas size (HP:0012094)2.82729419
18Metaphyseal cupping (HP:0003021)2.78072316
19Premature rupture of membranes (HP:0001788)2.77467814
20Follicular hyperkeratosis (HP:0007502)2.64551509
21Intrahepatic cholestasis (HP:0001406)2.60202529
22Volvulus (HP:0002580)2.55798169
23Arterial tortuosity (HP:0005116)2.54023467
24Vascular tortuosity (HP:0004948)2.53872781
25Abnormal tarsal ossification (HP:0008369)2.53348139
26Overlapping toe (HP:0001845)2.53208166
27Hypolipoproteinemia (HP:0010981)2.50892971
28Generalized aminoaciduria (HP:0002909)2.48498147
29Insulin-resistant diabetes mellitus (HP:0000831)2.45884348
30Mucopolysacchariduria (HP:0008155)2.44367552
31Urinary glycosaminoglycan excretion (HP:0003541)2.44367552
32Thoracolumbar scoliosis (HP:0002944)2.43454303
33Protuberant abdomen (HP:0001538)2.42516620
34Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.42216112
35Thyroid carcinoma (HP:0002890)2.38915716
36Ketoacidosis (HP:0001993)2.38433666
37Shoulder girdle muscle weakness (HP:0003547)2.37382378
38Abnormal umbilical cord blood vessels (HP:0011403)2.35205293
39Single umbilical artery (HP:0001195)2.35205293
40Abnormality of the fetal cardiovascular system (HP:0010948)2.35205293
41Abnormality of monocarboxylic acid metabolism (HP:0010996)2.32012117
42Microglossia (HP:0000171)2.30721899
43Abnormality of aromatic amino acid family metabolism (HP:0004338)2.30705490
44Abnormality of chromosome stability (HP:0003220)2.30110119
45Abnormality of methionine metabolism (HP:0010901)2.28226001
46Beaking of vertebral bodies (HP:0004568)2.25514321
47Tetraparesis (HP:0002273)2.25309410
48Platyspondyly (HP:0000926)2.23565960
49Delayed epiphyseal ossification (HP:0002663)2.23004561
50Cupped ribs (HP:0000887)2.21098379
51Abnormality of the musculature of the pelvis (HP:0001469)2.21081645
52Abnormality of the hip-girdle musculature (HP:0001445)2.21081645
53Aortic dissection (HP:0002647)2.19611255
54Hepatoblastoma (HP:0002884)2.18170693
55Aortic aneurysm (HP:0004942)2.18069396
56Chromsome breakage (HP:0040012)2.17102093
57Conjugated hyperbilirubinemia (HP:0002908)2.14455315
58Vitreoretinal degeneration (HP:0000655)2.13624992
59Deep philtrum (HP:0002002)2.13008648
60Abdominal distention (HP:0003270)2.07513656
61Deep venous thrombosis (HP:0002625)2.07226533
62Abnormality of polysaccharide metabolism (HP:0011012)2.07000711
63Abnormality of glycosaminoglycan metabolism (HP:0004371)2.07000711
64Abnormality of mucopolysaccharide metabolism (HP:0011020)2.07000711
65Fat malabsorption (HP:0002630)2.05612735
66Subacute progressive viral hepatitis (HP:0006572)2.04787013
67Hypoplastic ischia (HP:0003175)2.04584089
68Irregular vertebral endplates (HP:0003301)2.03400025
69Entropion (HP:0000621)2.03262364
70Breast carcinoma (HP:0003002)2.02827287
71Cutaneous melanoma (HP:0012056)2.02177930
72Nonimmune hydrops fetalis (HP:0001790)2.01740514
73Vertebral compression fractures (HP:0002953)2.01583272
74Chromosomal breakage induced by crosslinking agents (HP:0003221)2.01274559
75Osteolytic defects of the hand bones (HP:0009699)2.00996230
76Osteolytic defects of the phalanges of the hand (HP:0009771)2.00996230
77Abnormality of the distal phalanges of the toes (HP:0010182)2.00886829
78Steatorrhea (HP:0002570)2.00353030
79Hypobetalipoproteinemia (HP:0003563)2.00346797
80Abnormality of the umbilical cord (HP:0010881)2.00044090
81Flat capital femoral epiphysis (HP:0003370)1.98457270
82Upper limb muscle weakness (HP:0003484)1.98281950
83Thin bony cortex (HP:0002753)1.97409368
84Hepatocellular carcinoma (HP:0001402)1.97065625
85Small epiphyses (HP:0010585)1.95482397
86Hydroxyprolinuria (HP:0003080)1.95438381
87Abnormality of proline metabolism (HP:0010907)1.95438381
88Embryonal renal neoplasm (HP:0011794)1.93741553
89Abnormality of the ischium (HP:0003174)1.93625029
90Blue sclerae (HP:0000592)1.93570752
91Ependymoma (HP:0002888)1.93424769
92Nephroblastoma (Wilms tumor) (HP:0002667)1.92785777
93Pelvic girdle muscle weakness (HP:0003749)1.92355346
94Osteoarthritis (HP:0002758)1.92021972
95Biconcave vertebral bodies (HP:0004586)1.91383653
96Neoplasm of the adrenal gland (HP:0100631)1.90526624
97Curly hair (HP:0002212)1.90355535
98Abnormalities of placenta or umbilical cord (HP:0001194)1.90108694
99Spondylolisthesis (HP:0003302)1.89542910
100Soft skin (HP:0000977)1.89336813
101Exostoses (HP:0100777)1.88858022
102Abnormal delivery (HP:0001787)1.88628833
103Xanthomatosis (HP:0000991)1.88420265
104Prominent metopic ridge (HP:0005487)1.87803720
105Orthostatic hypotension (HP:0001278)1.87765881
106Bifid tongue (HP:0010297)1.87448585
107Skin nodule (HP:0200036)1.87426278
108Abnormality of dentin (HP:0010299)1.87061840
109Enlarged kidneys (HP:0000105)1.86719201
110Elevated alkaline phosphatase (HP:0003155)1.85727081
111Dysostosis multiplex (HP:0000943)1.85492186
112Atrophic scars (HP:0001075)1.85153894
113Ankle contracture (HP:0006466)1.85104731
114Neonatal short-limb short stature (HP:0008921)1.85092338
115Duodenal stenosis (HP:0100867)1.84501627
116Small intestinal stenosis (HP:0012848)1.84501627
117Disproportionate short-trunk short stature (HP:0003521)1.84326620
118Missing ribs (HP:0000921)1.83999525
119Asymmetry of the thorax (HP:0001555)1.83164951
120Intestinal atresia (HP:0011100)1.82493092
121Wormian bones (HP:0002645)1.82377814
12211 pairs of ribs (HP:0000878)1.81968112
123Abnormal enzyme/coenzyme activity (HP:0012379)1.81096314
124Aneurysm (HP:0002617)1.80777335
125Meckel diverticulum (HP:0002245)1.80283504
126Abnormality of alkaline phosphatase activity (HP:0004379)1.80162950
127Cardiovascular calcification (HP:0011915)1.79794082
128Papillary thyroid carcinoma (HP:0002895)1.79743585
129Peritonitis (HP:0002586)1.79702068
130Insulin resistance (HP:0000855)1.79545740
131Mesomelia (HP:0003027)1.79233487
132Gonadotropin excess (HP:0000837)1.78580404
133Late onset (HP:0003584)1.78520827
134Abnormal biliary tract morphology (HP:0012440)1.77670866
135Flat acetabular roof (HP:0003180)1.77619712
136Secondary amenorrhea (HP:0000869)1.77585449
137Delayed gross motor development (HP:0002194)1.76550176
138Irregular epiphyses (HP:0010582)1.76142822
139Ketosis (HP:0001946)1.75063345
140Abnormality of the vertebral endplates (HP:0005106)1.73993486
141Blepharitis (HP:0000498)1.73294264
142Abnormal lung lobation (HP:0002101)1.72380295
143Abnormality of the duodenum (HP:0002246)1.72292547
144Abnormality of the metopic suture (HP:0005556)1.72249936
145Abnormal cartilage morphology (HP:0002763)1.71963742
146Abnormality of the acetabulum (HP:0003170)1.71827659
147Osteomalacia (HP:0002749)1.71456591
148Hypoalphalipoproteinemia (HP:0003233)1.71373840
149Cortical dysplasia (HP:0002539)1.71202477
150Abnormality of the ileum (HP:0001549)1.70726444
151Metaphyseal irregularity (HP:0003025)1.70497704
152Severe short stature (HP:0003510)1.70218360
153Abnormality of glutamine family amino acid metabolism (HP:0010902)1.69641227
154Relative macrocephaly (HP:0004482)1.69434326
155Ovoid vertebral bodies (HP:0003300)1.68984580
156Femoral bowing (HP:0002980)1.68720878
157Hypoplasia of the odontoid process (HP:0003311)1.68586088
158Vacuolated lymphocytes (HP:0001922)1.67705378
159Abnormality of the anterior horn cell (HP:0006802)1.67573492
160Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.67229631
161Abnormality of the preputium (HP:0100587)1.67020969
162Abnormal protein glycosylation (HP:0012346)1.66537198
163Abnormal glycosylation (HP:0012345)1.66537198
164Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.66537198
165Abnormal protein N-linked glycosylation (HP:0012347)1.66537198
166Increased nuchal translucency (HP:0010880)1.66495250
167Short nail (HP:0001799)1.66442450
168Abnormal auditory evoked potentials (HP:0006958)1.65416125
169Aplasia/Hypoplasia of the uvula (HP:0010293)1.64416032
170Proximal tubulopathy (HP:0000114)1.62517950
171Rhabdomyosarcoma (HP:0002859)1.61568853
172Abnormality of carpal bone ossification (HP:0006257)1.60661934
173Ovarian neoplasm (HP:0100615)1.60250172
174Pulmonic stenosis (HP:0001642)1.60068856
175Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.58207587
176Degeneration of anterior horn cells (HP:0002398)1.57816777

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.77228584
2PASK3.37331669
3INSRR3.22614236
4TRIM283.09197052
5TSSK62.93944350
6NEK12.83321282
7TAOK32.70249709
8ERN12.67356515
9FLT32.49760718
10LATS12.45922197
11WEE12.25763468
12BUB12.21578991
13MAP3K122.19535722
14PDK22.07156159
15TTK2.06732839
16ERBB32.03811356
17EPHA31.98894807
18MAP3K31.98758264
19PDGFRA1.98427492
20TRIB31.87997120
21MAP3K21.87274673
22NEK91.87153193
23PTK61.82937063
24SIK11.80859975
25SRPK11.79578142
26PLK21.66459482
27JAK31.63818338
28NUAK11.63239759
29PKN21.60580936
30BRSK21.59014348
31FGFR41.58659340
32MET1.58065669
33SIK31.47913132
34MAP3K141.46203132
35PNCK1.45628954
36SCYL21.40474076
37PLK41.36443776
38STK31.33100250
39TAF11.32148691
40TGFBR11.26124064
41STK38L1.26087413
42TRPM71.25378201
43TESK11.24851918
44DDR21.22997533
45EPHA21.22166320
46MKNK21.20486690
47PTK21.19119437
48MKNK11.17128113
49AKT31.15684180
50EIF2AK31.14333028
51JAK11.13060651
52FGFR31.12869355
53RPS6KA41.12818902
54PIK3CG1.11506483
55MYLK1.10610182
56EIF2AK21.06003793
57CHUK1.05089831
58STK101.01756217
59MAP4K20.95985385
60KSR10.94091901
61BRD40.92707181
62MAPK150.92250547
63STK390.91956926
64TYK20.89369107
65FER0.88646812
66HIPK20.88326010
67BCKDK0.87819657
68PLK10.87466544
69PDGFRB0.85901515
70RIPK10.84294768
71MST40.81957112
72BMPR20.78381731
73ZAP700.78108481
74LRRK20.72867000
75ACVR1B0.71222550
76PIM20.70469456
77TGFBR20.69512394
78CDK60.69499233
79CDK120.69431350
80EPHB10.68949579
81RPS6KB10.67764731
82IRAK30.66805360
83PRKD30.66789204
84ERBB40.66686342
85TNIK0.66584939
86MST1R0.65221928
87PIK3CA0.65058416
88STK240.64753056
89YES10.64461478
90MELK0.64240719
91TBK10.64143416
92CCNB10.62206161
93NLK0.60300562
94IRAK40.58770125
95JAK20.58549531
96IGF1R0.58536882
97PLK30.57998508
98PRKCE0.57785292
99ITK0.57055918
100ATM0.56558873
101FGFR10.56400304
102CDC42BPA0.55809501
103CSNK1G10.54455698
104AURKB0.54414403
105PAK20.53257995
106BCR0.53101046
107MTOR0.52916782
108WNK30.52832327
109CHEK10.51267284
110PRKCH0.50889594
111BRSK10.50266143
112IRAK10.49973351
113TTN0.49025872
114PAK30.48846463
115CLK10.48338926
116WNK40.47672879
117PAK40.46501203
118LMTK20.46416643
119TIE10.45612024
120NEK20.45397275
121DYRK1B0.44359138
122NEK60.44262709
123PBK0.44221475
124PRKG20.42157627
125MAP3K40.41645416
126RPS6KB20.41609993
127PRKCI0.41554763
128ATR0.40882130
129FGFR20.40520112
130GSK3A0.39766164
131BRAF0.38666963
132BMPR1B0.38307453
133ZAK0.37782475
134LIMK10.37709672
135EIF2AK10.37186302
136CSNK1A1L0.36907214
137CDC70.36307707
138CDK90.35433572
139INSR0.35074129
140IKBKB0.34700948
141CDK70.34539243
142CHEK20.34480713
143CAMK1D0.32594202
144CDK80.32501614
145EPHB20.30139917
146STK40.28678934
147CSNK1G30.28270257
148MAP3K80.25576243
149LATS20.25366520
150RAF10.24648330
151ROCK10.24529936
152EGFR0.23971195

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.33541985
2Protein export_Homo sapiens_hsa030604.65400008
3Sulfur metabolism_Homo sapiens_hsa009203.56536204
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.15963941
5Proteasome_Homo sapiens_hsa030502.77039504
6Selenocompound metabolism_Homo sapiens_hsa004502.17234613
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.12235571
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.10961087
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.07644561
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.90690799
11Tryptophan metabolism_Homo sapiens_hsa003801.81551355
12Basal transcription factors_Homo sapiens_hsa030221.80247273
13RNA transport_Homo sapiens_hsa030131.72758670
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.66550332
15Fatty acid elongation_Homo sapiens_hsa000621.64821194
16Vitamin B6 metabolism_Homo sapiens_hsa007501.61166122
17N-Glycan biosynthesis_Homo sapiens_hsa005101.56691516
18Mismatch repair_Homo sapiens_hsa034301.55650446
19Nucleotide excision repair_Homo sapiens_hsa034201.51890844
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.51230863
21Cell cycle_Homo sapiens_hsa041101.50835235
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50610833
23Caffeine metabolism_Homo sapiens_hsa002321.49099065
24Pyruvate metabolism_Homo sapiens_hsa006201.47452127
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.46327339
26One carbon pool by folate_Homo sapiens_hsa006701.45285200
27Fatty acid degradation_Homo sapiens_hsa000711.44062496
28Complement and coagulation cascades_Homo sapiens_hsa046101.42957015
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42047272
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.40388080
31Starch and sucrose metabolism_Homo sapiens_hsa005001.37912609
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37783584
33Homologous recombination_Homo sapiens_hsa034401.37302744
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.34305753
35Protein digestion and absorption_Homo sapiens_hsa049741.34181160
36Fanconi anemia pathway_Homo sapiens_hsa034601.30590058
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.28587755
38ECM-receptor interaction_Homo sapiens_hsa045121.26811443
39Carbon metabolism_Homo sapiens_hsa012001.24177658
40Legionellosis_Homo sapiens_hsa051341.20333380
41RNA degradation_Homo sapiens_hsa030181.20090355
42Galactose metabolism_Homo sapiens_hsa000521.15733841
43Antigen processing and presentation_Homo sapiens_hsa046121.15320715
44Lysosome_Homo sapiens_hsa041421.13647377
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.13259553
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11177677
47Folate biosynthesis_Homo sapiens_hsa007901.07161959
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.02892033
49Other glycan degradation_Homo sapiens_hsa005110.99700536
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99651638
51Type I diabetes mellitus_Homo sapiens_hsa049400.98990672
52Histidine metabolism_Homo sapiens_hsa003400.98708834
53Fat digestion and absorption_Homo sapiens_hsa049750.98546448
54Focal adhesion_Homo sapiens_hsa045100.96799282
55Adherens junction_Homo sapiens_hsa045200.96634442
56Peroxisome_Homo sapiens_hsa041460.94372082
57Insulin resistance_Homo sapiens_hsa049310.94355528
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92962247
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.91502373
60Biosynthesis of amino acids_Homo sapiens_hsa012300.89541575
61Lysine degradation_Homo sapiens_hsa003100.89287164
62Vibrio cholerae infection_Homo sapiens_hsa051100.84049313
63Phenylalanine metabolism_Homo sapiens_hsa003600.83928976
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80913925
65DNA replication_Homo sapiens_hsa030300.80376277
66Staphylococcus aureus infection_Homo sapiens_hsa051500.80361128
67Prostate cancer_Homo sapiens_hsa052150.79759427
68TGF-beta signaling pathway_Homo sapiens_hsa043500.79569767
69Hippo signaling pathway_Homo sapiens_hsa043900.76785310
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74296663
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73472933
72Fatty acid metabolism_Homo sapiens_hsa012120.72243712
73Steroid biosynthesis_Homo sapiens_hsa001000.71506224
74Spliceosome_Homo sapiens_hsa030400.69974851
75Tyrosine metabolism_Homo sapiens_hsa003500.68273964
76Oocyte meiosis_Homo sapiens_hsa041140.68172023
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67977182
78ABC transporters_Homo sapiens_hsa020100.67907902
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.66970754
80Pentose phosphate pathway_Homo sapiens_hsa000300.65814411
81Chemical carcinogenesis_Homo sapiens_hsa052040.65344147
82Thyroid hormone synthesis_Homo sapiens_hsa049180.64511392
83Thyroid cancer_Homo sapiens_hsa052160.63831569
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62592239
85Bladder cancer_Homo sapiens_hsa052190.62198767
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61546050
87Proteoglycans in cancer_Homo sapiens_hsa052050.61009438
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60148800
89Renin-angiotensin system_Homo sapiens_hsa046140.59910188
90PPAR signaling pathway_Homo sapiens_hsa033200.59615633
91Butanoate metabolism_Homo sapiens_hsa006500.59215956
92Propanoate metabolism_Homo sapiens_hsa006400.58513350
93Toxoplasmosis_Homo sapiens_hsa051450.57375212
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.57030683
95Small cell lung cancer_Homo sapiens_hsa052220.56700109
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56582432
97Prolactin signaling pathway_Homo sapiens_hsa049170.55614920
98Amoebiasis_Homo sapiens_hsa051460.55213240
99mRNA surveillance pathway_Homo sapiens_hsa030150.54206390
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53786002
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53564958
102Circadian rhythm_Homo sapiens_hsa047100.53394997
103Tight junction_Homo sapiens_hsa045300.53119486
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.50954574
105PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50816932
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50193436
107Viral carcinogenesis_Homo sapiens_hsa052030.49369932
108Prion diseases_Homo sapiens_hsa050200.49346969
109Vitamin digestion and absorption_Homo sapiens_hsa049770.49082810
110Pyrimidine metabolism_Homo sapiens_hsa002400.48570085
111Non-homologous end-joining_Homo sapiens_hsa034500.48308637
112Chronic myeloid leukemia_Homo sapiens_hsa052200.48037314
113Type II diabetes mellitus_Homo sapiens_hsa049300.47218425
114Shigellosis_Homo sapiens_hsa051310.46982860
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46683551
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.46501240
117Metabolic pathways_Homo sapiens_hsa011000.45539746
118Leishmaniasis_Homo sapiens_hsa051400.45356412
119Phagosome_Homo sapiens_hsa041450.45187484
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44089615
121Measles_Homo sapiens_hsa051620.42038563
122Hepatitis C_Homo sapiens_hsa051600.41688351
123beta-Alanine metabolism_Homo sapiens_hsa004100.41432455
124MicroRNAs in cancer_Homo sapiens_hsa052060.41373758
125Purine metabolism_Homo sapiens_hsa002300.40620631
126Base excision repair_Homo sapiens_hsa034100.40055609
127RNA polymerase_Homo sapiens_hsa030200.39828481
128p53 signaling pathway_Homo sapiens_hsa041150.39512939
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39224736
130Pancreatic cancer_Homo sapiens_hsa052120.39100207
131SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38230040
132TNF signaling pathway_Homo sapiens_hsa046680.38229010
133Apoptosis_Homo sapiens_hsa042100.36414343
134Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36084093
135Malaria_Homo sapiens_hsa051440.34996870
136Glutathione metabolism_Homo sapiens_hsa004800.32896527
137Influenza A_Homo sapiens_hsa051640.32657600
138Retinol metabolism_Homo sapiens_hsa008300.32228286
139Hepatitis B_Homo sapiens_hsa051610.31397402
140Sphingolipid metabolism_Homo sapiens_hsa006000.31196525
141Arginine biosynthesis_Homo sapiens_hsa002200.30102038

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