COPE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)7.64980822
2* Golgi transport vesicle coating (GO:0048200)6.45896287
3* COPI coating of Golgi vesicle (GO:0048205)6.45896287
4GDP-mannose metabolic process (GO:0019673)5.41238822
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.41054382
6protein retention in ER lumen (GO:0006621)4.96705022
7protein maturation by protein folding (GO:0022417)4.69563176
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.50325736
9ATP synthesis coupled proton transport (GO:0015986)4.25043701
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.25043701
11Arp2/3 complex-mediated actin nucleation (GO:0034314)4.22147871
12respiratory chain complex IV assembly (GO:0008535)4.13776464
13COPII vesicle coating (GO:0048208)4.02840333
14protein complex biogenesis (GO:0070271)3.99870051
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.97105204
16cytidine deamination (GO:0009972)3.96332457
17cytidine metabolic process (GO:0046087)3.96332457
18cytidine catabolic process (GO:0006216)3.96332457
19negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.89641047
20cytochrome complex assembly (GO:0017004)3.87976263
21nucleotide transmembrane transport (GO:1901679)3.86172894
22regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.71861236
23L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.70380917
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.68845556
25respiratory electron transport chain (GO:0022904)3.67459041
26regulation of mitochondrial translation (GO:0070129)3.64443738
27electron transport chain (GO:0022900)3.62267840
28DNA deamination (GO:0045006)3.60749893
29SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.57979891
30mitochondrial respiratory chain complex assembly (GO:0033108)3.55204181
31cotranslational protein targeting to membrane (GO:0006613)3.54339874
32ER overload response (GO:0006983)3.54107380
33mannosylation (GO:0097502)3.53045623
34antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.52240114
35ribosomal small subunit assembly (GO:0000028)3.51868275
36protein targeting to ER (GO:0045047)3.50126901
37sequestering of metal ion (GO:0051238)3.50113515
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.48590540
39mitochondrial respiratory chain complex I assembly (GO:0032981)3.48590540
40NADH dehydrogenase complex assembly (GO:0010257)3.48590540
41peptidyl-histidine modification (GO:0018202)3.48511343
42dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.47379645
43protein localization to endoplasmic reticulum (GO:0070972)3.43767327
44NIK/NF-kappaB signaling (GO:0038061)3.43506584
45pyrimidine ribonucleoside catabolic process (GO:0046133)3.41800511
46antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.38566540
47exocrine pancreas development (GO:0031017)3.36645720
48* retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.35880802
49proteasome assembly (GO:0043248)3.34394060
50peptide hormone processing (GO:0016486)3.32410264
51cullin deneddylation (GO:0010388)3.31308047
52establishment of protein localization to endoplasmic reticulum (GO:0072599)3.30528735
53protein N-linked glycosylation via asparagine (GO:0018279)3.27513047
54endocrine pancreas development (GO:0031018)3.26246774
55negative regulation of myeloid cell apoptotic process (GO:0033033)3.25328691
56actin nucleation (GO:0045010)3.22001486
57purine deoxyribonucleotide catabolic process (GO:0009155)3.21793825
58protein deneddylation (GO:0000338)3.20789734
59peptidyl-asparagine modification (GO:0018196)3.20468609
60guanosine-containing compound biosynthetic process (GO:1901070)3.12181202
61regulation of oxidative phosphorylation (GO:0002082)3.10513612
62regulation of cellular amino acid metabolic process (GO:0006521)3.09205291
63protein N-linked glycosylation (GO:0006487)3.07007975
64viral protein processing (GO:0019082)3.06750193
65negative regulation of B cell apoptotic process (GO:0002903)3.03508456
66oxidative phosphorylation (GO:0006119)3.02950799
67amino acid salvage (GO:0043102)2.99587628
68L-methionine salvage (GO:0071267)2.99587628
69L-methionine biosynthetic process (GO:0071265)2.99587628
70chaperone mediated protein folding requiring cofactor (GO:0051085)2.96726088
71negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.95359656
72response to interferon-beta (GO:0035456)2.94114399
73iron-sulfur cluster assembly (GO:0016226)2.92078433
74metallo-sulfur cluster assembly (GO:0031163)2.92078433
75T cell apoptotic process (GO:0070231)2.92048986
76GMP metabolic process (GO:0046037)2.92016768
77immunoglobulin mediated immune response (GO:0016064)2.89634817
78glandular epithelial cell differentiation (GO:0002067)2.89116792
79ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.86023097
802-deoxyribonucleotide biosynthetic process (GO:0009265)2.85648287
81deoxyribose phosphate biosynthetic process (GO:0046385)2.85648287
82ER to Golgi vesicle-mediated transport (GO:0006888)2.84352638
83response to misfolded protein (GO:0051788)2.81948201
84viral mRNA export from host cell nucleus (GO:0046784)2.80387232
85positive regulation of lamellipodium organization (GO:1902745)2.79378863
86nuclear envelope reassembly (GO:0031468)2.79127389
87mitotic nuclear envelope reassembly (GO:0007084)2.79127389
88deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.78926976
89DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.78491665
90positive regulation of B cell differentiation (GO:0045579)2.78324008
91regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.77975413
92nucleotide-sugar biosynthetic process (GO:0009226)2.77051820
93positive regulation of gamma-delta T cell activation (GO:0046645)2.76771269
94peptidyl-arginine omega-N-methylation (GO:0035247)2.75502578
95negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.74945171
96antigen processing and presentation of endogenous antigen (GO:0019883)2.74269704
97regulation of superoxide anion generation (GO:0032928)2.73254166
98signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.73012192
99signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.73012192
100signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.73012192
101signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.72862936
102intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.72862936
103chaperone-mediated protein transport (GO:0072321)2.72525529
104negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.71843373
105negative regulation of ligase activity (GO:0051352)2.71843373
106pyrimidine-containing compound salvage (GO:0008655)2.71833504
107pyrimidine nucleoside salvage (GO:0043097)2.71833504
108proline biosynthetic process (GO:0006561)2.71481018
109translation (GO:0006412)2.67554427
110nucleotide-sugar metabolic process (GO:0009225)2.66970328
111tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.66804878
112RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.66804878
113antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.66719633
114regulation of type B pancreatic cell apoptotic process (GO:2000674)2.66585684
115pentose-phosphate shunt (GO:0006098)2.66523210
116mature B cell differentiation involved in immune response (GO:0002313)2.65989519
117activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.65548342
118deoxyribonucleotide catabolic process (GO:0009264)2.65143295
119regulation of defense response to virus by virus (GO:0050690)2.65050608
120cell redox homeostasis (GO:0045454)2.64424978
121heme biosynthetic process (GO:0006783)2.64377001
122peptide metabolic process (GO:0006518)2.63445884
123GPI anchor biosynthetic process (GO:0006506)2.63184069
124antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.62194826
125positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.61854016
126virion assembly (GO:0019068)2.61740176
127GTP biosynthetic process (GO:0006183)2.60438733
128purine nucleotide salvage (GO:0032261)2.59660386
129barbed-end actin filament capping (GO:0051016)2.59522739
130positive regulation of monocyte chemotaxis (GO:0090026)2.58721239
131nucleoside diphosphate catabolic process (GO:0009134)2.57082946
132signal transduction involved in DNA integrity checkpoint (GO:0072401)2.56988844
133signal transduction involved in DNA damage checkpoint (GO:0072422)2.56988844
134positive regulation of nuclease activity (GO:0032075)2.56906935
135negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.54940934
136amyloid precursor protein catabolic process (GO:0042987)2.53580453
137deoxyribose phosphate catabolic process (GO:0046386)2.53515570
138positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.53172930
139misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.53130522
140pentose metabolic process (GO:0019321)2.51840218
141UV protection (GO:0009650)2.51594285
142negative regulation of stress fiber assembly (GO:0051497)2.50128365
143lipopolysaccharide-mediated signaling pathway (GO:0031663)2.49574429
144nucleotide salvage (GO:0043173)2.49571738
145antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.48968566
146pinocytosis (GO:0006907)2.48677635
147cellular response to interferon-beta (GO:0035458)2.48392528
148signal transduction involved in cell cycle checkpoint (GO:0072395)2.42505780
149NADH metabolic process (GO:0006734)2.42284316
150regulation of metalloenzyme activity (GO:0048552)2.41591986
151pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.41388595
152lymphocyte apoptotic process (GO:0070227)2.41031883
153deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.40523852
154establishment of viral latency (GO:0019043)2.39195654
155regulation of mitochondrial membrane potential (GO:0051881)2.38577944
156negative regulation of cell size (GO:0045792)2.38189262
157positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.36885259
158regulation of release of cytochrome c from mitochondria (GO:0090199)2.36593453
159purine deoxyribonucleotide metabolic process (GO:0009151)2.36543715
160positive thymic T cell selection (GO:0045059)2.36451065
161glucose catabolic process (GO:0006007)2.35698678
162cellular response to type I interferon (GO:0071357)2.35007577
163type I interferon signaling pathway (GO:0060337)2.35007577
164amino sugar catabolic process (GO:0046348)2.33049829
165negative regulation of viral genome replication (GO:0045071)2.32802016
166leukocyte apoptotic process (GO:0071887)2.30655726
1672-deoxyribonucleotide metabolic process (GO:0009394)2.30519280
168extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)2.27871105
169response to type I interferon (GO:0034340)2.27676555

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human5.33813916
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.67042491
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.49710721
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.09739592
5PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.89987665
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.73062071
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.19415620
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.13859946
9* ELF1_17652178_ChIP-ChIP_JURKAT_Human3.09024847
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.05578502
11SRF_21415370_ChIP-Seq_HL-1_Mouse2.87164555
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.79253467
13* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.77276179
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.76364451
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.71017499
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.69747546
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.64506709
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.54443927
19VDR_21846776_ChIP-Seq_THP-1_Human2.43834183
20DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.40740834
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.29755890
22VDR_23849224_ChIP-Seq_CD4+_Human2.29690407
23* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25555808
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.24722760
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.23626221
26* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.20368553
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.17848258
28LXR_22292898_ChIP-Seq_THP-1_Human2.16639508
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14059361
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13803746
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.12896181
32DCP1A_22483619_ChIP-Seq_HELA_Human2.11666208
33YY1_21170310_ChIP-Seq_MESCs_Mouse2.09818521
34E2F1_18555785_ChIP-Seq_MESCs_Mouse2.09442994
35CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.06337139
36* GABP_19822575_ChIP-Seq_HepG2_Human2.02621126
37MYC_18555785_ChIP-Seq_MESCs_Mouse1.99036523
38FOXP3_21729870_ChIP-Seq_TREG_Human1.95980982
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.91269233
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.90447768
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.89180216
42ERG_20887958_ChIP-Seq_HPC-7_Mouse1.88000868
43ZNF263_19887448_ChIP-Seq_K562_Human1.85601117
44SRY_22984422_ChIP-ChIP_TESTIS_Rat1.84858519
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.84147995
46MYC_22102868_ChIP-Seq_BL_Human1.78370900
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.77403635
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76525980
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71905989
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62867515
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.61601221
52TET1_21451524_ChIP-Seq_MESCs_Mouse1.60057106
53ELK1_19687146_ChIP-ChIP_HELA_Human1.58912898
54DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.57908361
55BCL6_27268052_Chip-Seq_Bcells_Human1.57558341
56* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.55313413
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55064198
58BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.53973333
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.53753631
60P68_20966046_ChIP-Seq_HELA_Human1.53264534
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53007838
62UTX_26944678_Chip-Seq_JUKART_Human1.49610852
63XRN2_22483619_ChIP-Seq_HELA_Human1.47323146
64MAF_26560356_Chip-Seq_TH1_Human1.44531035
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.43527203
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43183963
67VDR_24763502_ChIP-Seq_THP-1_Human1.41672422
68RACK7_27058665_Chip-Seq_MCF-7_Human1.40230240
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.40106375
70BCOR_27268052_Chip-Seq_Bcells_Human1.40054340
71MAF_26560356_Chip-Seq_TH2_Human1.39547340
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.36589218
73MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34590713
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34389778
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34216297
76ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.33439144
77GATA1_22025678_ChIP-Seq_K562_Human1.33235217
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32816313
79SA1_27219007_Chip-Seq_ERYTHROID_Human1.31691795
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30639124
81* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29556024
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27149859
83CTCF_26484167_Chip-Seq_Bcells_Mouse1.25750074
84NELFA_20434984_ChIP-Seq_ESCs_Mouse1.25590809
85RUNX1_22412390_ChIP-Seq_EML_Mouse1.24614882
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24396603
87E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23098198
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.22539747
89SPI1_23547873_ChIP-Seq_NB4_Human1.20841241
90STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19895999
91KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19771373
92TFEB_21752829_ChIP-Seq_HELA_Human1.16542912
93ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16446159
94IRF8_21731497_ChIP-ChIP_J774_Mouse1.16105927
95LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14079396
96* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.13599928
97BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13523151
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13180337
99TTF2_22483619_ChIP-Seq_HELA_Human1.12803461
100KDM2B_26808549_Chip-Seq_DND41_Human1.11863203
101CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09978494
102PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09126988
103CTCF_18555785_ChIP-Seq_MESCs_Mouse1.08784593
104CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08164738
105CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.07800144
106EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.07495795
107CIITA_25753668_ChIP-Seq_RAJI_Human1.07207958
108ERG_20517297_ChIP-Seq_VCAP_Human1.06372926
109PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06308454
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04610573
111IRF1_19129219_ChIP-ChIP_H3396_Human1.03907925
112PHF8_20622854_ChIP-Seq_HELA_Human1.02337363
113YY1_22570637_ChIP-Seq_MALME-3M_Human1.02108591
114HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01722028
115TCF7_22412390_ChIP-Seq_EML_Mouse1.01691234
116TBX5_21415370_ChIP-Seq_HL-1_Mouse1.01662402
117TP63_17297297_ChIP-ChIP_HaCaT_Human1.01614690
118E2F1_20622854_ChIP-Seq_HELA_Human1.01461067
119RARB_24833708_ChIP-Seq_LIVER_Mouse1.01361948
120GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99649811
121MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99064023
122AR_20517297_ChIP-Seq_VCAP_Human0.98622620
123PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98253732
124MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.95053833
125RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92256629
126* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91824317
127STAT1_20625510_ChIP-Seq_HELA_Human0.91610461
128TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90799316
129E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.90601452
130NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89970182
131PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89912725
132STAT4_19710469_ChIP-ChIP_TH1__Mouse0.88038784
133SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87963613
134YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85539391
135KDM5A_27292631_Chip-Seq_BREAST_Human0.85162947
136EGR1_23403033_ChIP-Seq_LIVER_Mouse0.84364049
137SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83347064
138SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82771140
139ELF1_20517297_ChIP-Seq_JURKAT_Human0.81770565
140GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81451096
141CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.80396002

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.52487876
2MP0010386_abnormal_urinary_bladder3.35639669
3MP0004043_abnormal_pH_regulation3.19770805
4MP0005220_abnormal_exocrine_pancreas3.12359424
5MP0003183_abnormal_peptide_metabolism3.07471870
6MP0005451_abnormal_body_composition2.86206022
7MP0002693_abnormal_pancreas_physiology2.84518662
8MP0003283_abnormal_digestive_organ2.83830811
9MP0000013_abnormal_adipose_tissue2.70835370
10MP0002877_abnormal_melanocyte_morpholog2.55135019
11MP0005379_endocrine/exocrine_gland_phen2.52538026
12MP0006082_CNS_inflammation2.46534192
13MP0001944_abnormal_pancreas_morphology2.41062386
14MP0001986_abnormal_taste_sensitivity2.37994150
15MP0005058_abnormal_lysosome_morphology2.31117777
16MP0005084_abnormal_gallbladder_morpholo2.30165665
17MP0001873_stomach_inflammation2.29849198
18MP0003806_abnormal_nucleotide_metabolis2.28446809
19MP0003303_peritoneal_inflammation2.26599049
20MP0005464_abnormal_platelet_physiology2.23694974
21MP0002909_abnormal_adrenal_gland2.21338949
22MP0000678_abnormal_parathyroid_gland2.18521213
23MP0002876_abnormal_thyroid_physiology2.10847629
24MP0000465_gastrointestinal_hemorrhage2.08268732
25MP0003763_abnormal_thymus_physiology2.07453894
26MP0005646_abnormal_pituitary_gland2.02824346
27MP0003075_altered_response_to1.98975764
28MP0003186_abnormal_redox_activity1.96957429
29MP0003724_increased_susceptibility_to1.94665864
30MP0002638_abnormal_pupillary_reflex1.94589907
31MP0001764_abnormal_homeostasis1.93159098
32MP0006036_abnormal_mitochondrial_physio1.90754683
33MP0002452_abnormal_antigen_presenting1.90360976
34MP0001800_abnormal_humoral_immune1.90188992
35MP0002837_dystrophic_cardiac_calcinosis1.80936393
36MP0002148_abnormal_hypersensitivity_rea1.77687735
37MP0000858_altered_metastatic_potential1.77320541
38MP0005636_abnormal_mineral_homeostasis1.76518461
39MP0009278_abnormal_bone_marrow1.73170948
40MP0001666_abnormal_nutrient_absorption1.72480161
41MP0005365_abnormal_bile_salt1.72247435
42MP0009785_altered_susceptibility_to1.71575808
43MP0005083_abnormal_biliary_tract1.69816955
44MP0001853_heart_inflammation1.69542653
45MP0004510_myositis1.69135263
46MP0009643_abnormal_urine_homeostasis1.66176305
47MP0000343_altered_response_to1.66013265
48MP0002163_abnormal_gland_morphology1.65745094
49MP0005671_abnormal_response_to1.64356118
50MP0006054_spinal_hemorrhage1.63992469
51MP0001835_abnormal_antigen_presentation1.61061059
52MP0000716_abnormal_immune_system1.58001720
53MP0002398_abnormal_bone_marrow1.57365280
54MP0005408_hypopigmentation1.53501322
55MP0000372_irregular_coat_pigmentation1.52815793
56MP0010155_abnormal_intestine_physiology1.51781880
57MP0004947_skin_inflammation1.50219644
58MP0000604_amyloidosis1.48647033
59MP0002722_abnormal_immune_system1.48619522
60MP0009780_abnormal_chondrocyte_physiolo1.48603975
61MP0002429_abnormal_blood_cell1.45367503
62MP0003300_gastrointestinal_ulcer1.42582020
63MP0002139_abnormal_hepatobiliary_system1.42008299
64MP0003866_abnormal_defecation1.41868999
65MP0003172_abnormal_lysosome_physiology1.41533125
66MP0002078_abnormal_glucose_homeostasis1.39849086
67MP0003329_amyloid_beta_deposits1.39130161
68MP0004264_abnormal_extraembryonic_tissu1.38835085
69MP0004782_abnormal_surfactant_physiolog1.37543214
70MP0005166_decreased_susceptibility_to1.36483948
71MP0000681_abnormal_thyroid_gland1.36390479
72MP0002405_respiratory_system_inflammati1.34674806
73MP0000689_abnormal_spleen_morphology1.33985127
74MP0004858_abnormal_nervous_system1.32359135
75MP0009764_decreased_sensitivity_to1.27011932
76MP0001905_abnormal_dopamine_level1.26030993
77MP0005075_abnormal_melanosome_morpholog1.23917918
78MP0002933_joint_inflammation1.23254915
79MP0000613_abnormal_salivary_gland1.22024050
80MP0005310_abnormal_salivary_gland1.21867607
81MP0003122_maternal_imprinting1.20964569
82MP0003693_abnormal_embryo_hatching1.20930972
83MP0005025_abnormal_response_to1.20579503
84MP0004147_increased_porphyrin_level1.20176525
85MP0001756_abnormal_urination1.18924365
86MP0000703_abnormal_thymus_morphology1.18864723
87MP0001529_abnormal_vocalization1.18804207
88MP0000490_abnormal_crypts_of1.18447698
89MP0003436_decreased_susceptibility_to1.16564312
90MP0001542_abnormal_bone_strength1.14857442
91MP0001664_abnormal_digestion1.10679199
92MP0001790_abnormal_immune_system1.09464406
93MP0005387_immune_system_phenotype1.09464406
94MP0001765_abnormal_ion_homeostasis1.08942225
95MP0003786_premature_aging1.08903378
96MP0005000_abnormal_immune_tolerance1.08672993
97MP0006072_abnormal_retinal_apoptosis1.07456361
98MP0001727_abnormal_embryo_implantation1.06030245
99MP0002419_abnormal_innate_immunity1.05874346
100MP0008469_abnormal_protein_level1.05687931
101MP0002132_abnormal_respiratory_system1.05275748
102MP0005360_urolithiasis1.05069344
103MP0005397_hematopoietic_system_phenotyp1.03804520
104MP0001545_abnormal_hematopoietic_system1.03804520
105MP0002019_abnormal_tumor_incidence1.03673135
106MP0009763_increased_sensitivity_to1.01861860
107MP0003959_abnormal_lean_body1.01600106
108MP0001845_abnormal_inflammatory_respons1.00991903
109MP0005165_increased_susceptibility_to1.00773362
110MP0005645_abnormal_hypothalamus_physiol1.00497950
111MP0005332_abnormal_amino_acid1.00297796
112MP0009333_abnormal_splenocyte_physiolog0.98573291
113MP0001533_abnormal_skeleton_physiology0.98254190
114MP0003448_altered_tumor_morphology0.96694734
115MP0002938_white_spotting0.95710709
116MP0000538_abnormal_urinary_bladder0.92024301
117MP0002277_abnormal_respiratory_mucosa0.90870647
118MP0003953_abnormal_hormone_level0.90803200
119MP0008875_abnormal_xenobiotic_pharmacok0.89742608
120MP0001663_abnormal_digestive_system0.89697561
121MP0006276_abnormal_autonomic_nervous0.89527827
122MP0008438_abnormal_cutaneous_collagen0.89399060
123MP0008260_abnormal_autophagy0.89045068
124MP0009379_abnormal_foot_pigmentation0.88689423
125MP0009840_abnormal_foam_cell0.86928907
126MP0008004_abnormal_stomach_pH0.86782762
127MP0005390_skeleton_phenotype0.86570557
128MP0000230_abnormal_systemic_arterial0.85247976
129MP0003656_abnormal_erythrocyte_physiolo0.85196325
130MP0000003_abnormal_adipose_tissue0.84538410
131MP0000750_abnormal_muscle_regeneration0.81938761
132MP0008874_decreased_physiological_sensi0.81086754
133MP0002723_abnormal_immune_serum0.80787823
134MP0009642_abnormal_blood_homeostasis0.79086671
135MP0002234_abnormal_pharynx_morphology0.78395720
136MP0003191_abnormal_cellular_cholesterol0.77646099
137MP0002138_abnormal_hepatobiliary_system0.77274202
138MP0005501_abnormal_skin_physiology0.76083982
139MP0002420_abnormal_adaptive_immunity0.76015846
140MP0005319_abnormal_enzyme/_coenzyme0.75820667
141MP0005584_abnormal_enzyme/coenzyme_acti0.75307745
142MP0008873_increased_physiological_sensi0.74449678
143MP0001819_abnormal_immune_cell0.74393734
144MP0005330_cardiomyopathy0.73939845
145MP0003111_abnormal_nucleus_morphology0.73312591
146MP0001188_hyperpigmentation0.72544838
147MP0000313_abnormal_cell_death0.71514579
148MP0000685_abnormal_immune_system0.71460457
149MP0000358_abnormal_cell_content/0.69105742
150MP0003868_abnormal_feces_composition0.68429701
151MP0002998_abnormal_bone_remodeling0.68163995
152MP0006035_abnormal_mitochondrial_morpho0.67628695
153MP0005666_abnormal_adipose_tissue0.67129773
154MP0008007_abnormal_cellular_replicative0.66833624
155MP0003453_abnormal_keratinocyte_physiol0.64286086
156MP0008932_abnormal_embryonic_tissue0.63878014
157MP0003221_abnormal_cardiomyocyte_apopto0.63293588

Predicted human phenotypes

RankGene SetZ-score
1Hepatic necrosis (HP:0002605)4.54069898
2Increased IgM level (HP:0003496)4.53901689
3Acute necrotizing encephalopathy (HP:0006965)4.44009313
4Abnormal mitochondria in muscle tissue (HP:0008316)4.33882712
5Hepatocellular necrosis (HP:0001404)4.32721502
6Mitochondrial inheritance (HP:0001427)4.30962233
7Type I transferrin isoform profile (HP:0003642)4.25676795
8Autoimmune thrombocytopenia (HP:0001973)3.95912769
9Acute encephalopathy (HP:0006846)3.93782208
10Hypoglycemic seizures (HP:0002173)3.78686883
11Hypoglycemic coma (HP:0001325)3.73819017
12Abnormal protein glycosylation (HP:0012346)3.68978758
13Abnormal glycosylation (HP:0012345)3.68978758
14Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.68978758
15Abnormal protein N-linked glycosylation (HP:0012347)3.68978758
16Increased CSF lactate (HP:0002490)3.68260718
17Abnormality of glycolipid metabolism (HP:0010969)3.66509274
18Abnormality of liposaccharide metabolism (HP:0010968)3.66509274
19Abnormality of glycosphingolipid metabolism (HP:0004343)3.66509274
20Symptomatic seizures (HP:0011145)3.54707547
21Autoimmune hemolytic anemia (HP:0001890)3.49352761
22Abnormality of macrophages (HP:0004311)3.42404824
23Vacuolated lymphocytes (HP:0001922)3.41638947
24Hyperinsulinemic hypoglycemia (HP:0000825)3.34898651
25Generalized aminoaciduria (HP:0002909)3.31542562
26Progressive macrocephaly (HP:0004481)3.28017825
27Decreased activity of mitochondrial respiratory chain (HP:0008972)3.26958814
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.26958814
293-Methylglutaconic aciduria (HP:0003535)3.15435279
30Abnormality of aromatic amino acid family metabolism (HP:0004338)3.10365307
31Obstructive lung disease (HP:0006536)3.04962360
32Chronic obstructive pulmonary disease (HP:0006510)3.04962360
33Hypothermia (HP:0002045)3.01773460
34Vertebral compression fractures (HP:0002953)2.98885067
35Abnormal delayed hypersensitivity skin test (HP:0002963)2.96222264
36Abnormal gallbladder physiology (HP:0012438)2.93143225
37Cholecystitis (HP:0001082)2.93143225
38Reduced antithrombin III activity (HP:0001976)2.88361698
39Agammaglobulinemia (HP:0004432)2.85183984
40Mediastinal lymphadenopathy (HP:0100721)2.84382527
41Lactic acidosis (HP:0003128)2.83356399
42Ragged-red muscle fibers (HP:0003200)2.83329353
43Recurrent abscess formation (HP:0002722)2.77034134
44Eczematoid dermatitis (HP:0000976)2.76450230
45Granulocytopenia (HP:0001913)2.70102411
46Hypergammaglobulinemia (HP:0010702)2.68320386
47Neuroendocrine neoplasm (HP:0100634)2.68264873
48Cellulitis (HP:0100658)2.62836820
49Renal Fanconi syndrome (HP:0001994)2.61722314
50Increased intramyocellular lipid droplets (HP:0012240)2.61341980
51Purpura (HP:0000979)2.60499167
52Hepatosplenomegaly (HP:0001433)2.59324298
53Exercise intolerance (HP:0003546)2.58764968
54Lipid accumulation in hepatocytes (HP:0006561)2.58516857
55Pheochromocytoma (HP:0002666)2.57825492
56Abnormality of the intrinsic pathway (HP:0010989)2.57502353
57Urticaria (HP:0001025)2.56043282
58Increased serum lactate (HP:0002151)2.54953154
59Respiratory failure (HP:0002878)2.53036608
60Increased muscle lipid content (HP:0009058)2.52911167
61Meningitis (HP:0001287)2.51503935
62Cerebral edema (HP:0002181)2.50059555
63Hypertensive crisis (HP:0100735)2.49873977
64Increased serum ferritin (HP:0003281)2.49394511
65Increased hepatocellular lipid droplets (HP:0006565)2.49305396
66Recurrent bacterial skin infections (HP:0005406)2.48239597
67Ketoacidosis (HP:0001993)2.45257494
68Late onset (HP:0003584)2.43172541
69Dysostosis multiplex (HP:0000943)2.40397210
70Glycosuria (HP:0003076)2.39692244
71Abnormality of urine glucose concentration (HP:0011016)2.39692244
72Prolonged neonatal jaundice (HP:0006579)2.38893603
73Mucopolysacchariduria (HP:0008155)2.34469025
74Urinary glycosaminoglycan excretion (HP:0003541)2.34469025
75Abnormality of T cell physiology (HP:0011840)2.33384531
76Abnormality of fatty-acid metabolism (HP:0004359)2.29868732
77Rough bone trabeculation (HP:0100670)2.28435128
78Eosinophilia (HP:0001880)2.27541269
79Increased cerebral lipofuscin (HP:0011813)2.27056639
80Beaking of vertebral bodies (HP:0004568)2.26641632
81Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.23171535
82Abnormality of T cell number (HP:0011839)2.21694404
83Systemic lupus erythematosus (HP:0002725)2.20900701
84Abnormality of dicarboxylic acid metabolism (HP:0010995)2.18170563
85Dicarboxylic aciduria (HP:0003215)2.18170563
86Loss of speech (HP:0002371)2.16036143
87Abnormality of the pancreatic islet cells (HP:0006476)2.14545663
88Abnormality of endocrine pancreas physiology (HP:0012093)2.14545663
89Absent rod-and cone-mediated responses on ERG (HP:0007688)2.14300833
90Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.13653481
91Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.12268816
92True hermaphroditism (HP:0010459)2.11998569
93Progressive neurologic deterioration (HP:0002344)2.11159720
94Aplastic anemia (HP:0001915)2.09867337
95J-shaped sella turcica (HP:0002680)2.08835949
96Opisthotonus (HP:0002179)2.07025337
97Optic disc pallor (HP:0000543)2.06554474
98Myositis (HP:0100614)2.06133706
99CNS demyelination (HP:0007305)2.05391479
100Hyperphosphaturia (HP:0003109)2.05007498
101Decreased circulating renin level (HP:0003351)2.04782296
102Abnormality of T cells (HP:0002843)2.04739632
103Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.04138746
104Achilles tendon contracture (HP:0001771)2.03877701
105Increased IgE level (HP:0003212)2.02851225
106Premature skin wrinkling (HP:0100678)2.02696339
107Abnormality of polysaccharide metabolism (HP:0011012)2.01142742
108Abnormality of glycosaminoglycan metabolism (HP:0004371)2.01142742
109Abnormality of mucopolysaccharide metabolism (HP:0011020)2.01142742
110Exertional dyspnea (HP:0002875)1.99343736
111Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.99217752
112Axonal loss (HP:0003447)1.98572556
113Abnormality of renal resorption (HP:0011038)1.98104201
114Distal lower limb muscle weakness (HP:0009053)1.97737778
115Glucose intolerance (HP:0000833)1.95580818
116Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.95473747
117Increased neuronal autofluorescent lipopigment (HP:0002074)1.95235785
118Abnormality of cells of the lymphoid lineage (HP:0012140)1.95122013
119Microvesicular hepatic steatosis (HP:0001414)1.94610378
120Large for gestational age (HP:0001520)1.94425767
121Conjugated hyperbilirubinemia (HP:0002908)1.93359900
122Recurrent viral infections (HP:0004429)1.92455452
123Abnormal rod and cone electroretinograms (HP:0008323)1.92339005
124Emotional lability (HP:0000712)1.91971892
125Stomatitis (HP:0010280)1.91631913
126Thrombocytosis (HP:0001894)1.90550551
127Abnormality of calcium-phosphate metabolism (HP:0100530)1.90473294
128Poor head control (HP:0002421)1.89708435
129Irregular vertebral endplates (HP:0003301)1.89209912
130Medial flaring of the eyebrow (HP:0010747)1.87810940
131Palpitations (HP:0001962)1.87805499
132Skin rash (HP:0000988)1.87385721
133Leukodystrophy (HP:0002415)1.87344010
134Abnormality of glycolysis (HP:0004366)1.87281823
135Increased serum pyruvate (HP:0003542)1.87281823
136Methylmalonic aciduria (HP:0012120)1.85562986
137Vasculitis (HP:0002633)1.84959322
138Pancreatic fibrosis (HP:0100732)1.84426689
139Petechiae (HP:0000967)1.84197050
140Amyloidosis (HP:0011034)1.84114498
141Hyperglycemia (HP:0003074)1.83601100
142Pancreatic islet-cell hyperplasia (HP:0004510)1.83342921
143Cholelithiasis (HP:0001081)1.82324976
144Abnormality of the Achilles tendon (HP:0005109)1.82048742
145Recurrent fungal infections (HP:0002841)1.81895367
146Neoplasm of the adrenal gland (HP:0100631)1.80558817
147Microretrognathia (HP:0000308)1.79349059
148Cerebral palsy (HP:0100021)1.78301061
149Abnormality of iron homeostasis (HP:0011031)1.77826977
150Neutropenia (HP:0001875)1.77538957
151Lethargy (HP:0001254)1.77362387
152Disproportionate short-trunk short stature (HP:0003521)1.74769406
153Hypochromic anemia (HP:0001931)1.74581515
154Elevated erythrocyte sedimentation rate (HP:0003565)1.73661957
155Growth hormone excess (HP:0000845)1.72864821
156Rhabdomyolysis (HP:0003201)1.72428468
157Myopathic facies (HP:0002058)1.72400574
158Epiphyseal stippling (HP:0010655)1.71816999
159Abnormal pupillary function (HP:0007686)1.71511662
160Hypertriglyceridemia (HP:0002155)1.71498139
161Testicular atrophy (HP:0000029)1.70986014
162Long palpebral fissure (HP:0000637)1.70648892
163Acute hepatic failure (HP:0006554)1.69963773
164Dysautonomia (HP:0002459)1.69840395
165Orthostatic hypotension (HP:0001278)1.69389639
166Abnormal trabecular bone morphology (HP:0100671)1.69283395
167Encephalitis (HP:0002383)1.69141953
168Sepsis (HP:0100806)1.68679632
169Distal upper limb amyotrophy (HP:0007149)1.67742937
170Upper limb amyotrophy (HP:0009129)1.67742937
171Poor suck (HP:0002033)1.67442348

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.03176403
2BCKDK3.03472518
3MAPK153.00166394
4PASK2.80820267
5ERN12.76175869
6INSRR2.75428196
7IRAK42.66238476
8IRAK32.61665055
9NME22.46102391
10EIF2AK32.44758439
11VRK22.34787110
12MAP3K122.31188706
13PIM22.21377404
14NME12.18828497
15ARAF2.09309104
16MYLK2.08198621
17SMG11.90090704
18BUB11.88190502
19TAOK21.86352825
20PIK3CG1.84854717
21TRIB31.68815768
22WNK41.65161825
23TSSK61.60442852
24PRPF4B1.59900400
25VRK11.58216882
26BRAF1.52074664
27GRK61.45804032
28FLT31.44008119
29TESK11.43609615
30IRAK11.41279032
31ZAP701.27033891
32TAOK31.18826200
33MST41.16787288
34TBK11.15953472
35EIF2AK11.14638449
36BRSK21.07827459
37LIMK11.07413066
38MAP3K21.07247432
39TEC1.05838889
40ADRBK21.03379790
41CAMKK21.03012123
42HIPK21.02796520
43PBK1.01738777
44MAPKAPK30.98827215
45PAK40.98825628
46TESK20.98516752
47KDR0.98454851
48RIPK40.98145731
49EPHA20.97706083
50BLK0.96459499
51IKBKE0.95607819
52AKT30.94549419
53BMPR20.93378311
54AURKA0.90098079
55BMPR1B0.88767159
56TXK0.88291183
57MAP3K140.85597023
58CDK190.84940966
59BTK0.83676960
60FES0.82240459
61KIT0.81323112
62MAP2K20.79658507
63MAP3K110.79559843
64ACVR1B0.79525940
65CASK0.78724284
66MUSK0.77560078
67STK100.76160949
68CSNK1G30.75304985
69LRRK20.75232495
70WNK30.74876763
71TAOK10.74604384
72SYK0.74385471
73PRKCI0.74269287
74MAP2K60.74101913
75GRK70.72977382
76MAP4K10.72757436
77ILK0.72400938
78IRAK20.72081295
79LMTK20.71016778
80MAP3K60.70891354
81MAP3K30.69756231
82PAK10.69599806
83CCNB10.69438210
84BCR0.69038406
85MAPKAPK50.68915271
86JAK30.68879298
87ZAK0.68520378
88MOS0.68494565
89TYK20.64964053
90OBSCN0.64664280
91NLK0.64485795
92SIK10.63651339
93DAPK10.63377393
94TNIK0.63023150
95ICK0.60997591
96MAP2K30.60558658
97PIK3CA0.60507500
98MATK0.59797066
99MAP3K10.58951973
100EPHB10.58469115
101PRKG20.58318919
102TNK20.57705450
103PRKCE0.56130582
104CSK0.56095808
105CDK80.54691722
106CSF1R0.54598978
107LCK0.54366474
108BRSK10.53797891
109MAPK110.52528555
110MAP3K50.51630880
111PRKD20.51589347
112PRKCH0.51493510
113SIK30.51052368
114MAP3K80.51043971
115TLK10.49529348
116CSNK1A1L0.47838725
117IKBKB0.47258585
118SCYL20.47002321
119RPS6KB20.46554891
120LYN0.45642223
121ADRBK10.45477458
122CAMK2D0.45048567
123MAP2K70.44923107
124MAPKAPK20.43890809
125EEF2K0.42883850
126PTK20.42451131
127ABL20.41785162
128MAPK120.41184307
129NEK60.40792218
130RPS6KA50.40771531
131CSNK2A10.40666568
132RPS6KA60.40463090
133PDPK10.40280266
134TGFBR20.39130503
135PRKD10.39051639
136EPHA30.37967365
137UHMK10.37118134
138ITK0.36521501
139CAMK2G0.36388561
140RPS6KL10.35693369
141RPS6KC10.35693369
142DYRK20.35639493
143CDK140.35383333
144DAPK30.35322344
145PRKCD0.35018526
146RET0.34692633
147RAF10.34513501
148CDK11A0.33688073
149GRK50.32108102
150CDK70.31518486
151HCK0.30056506
152PIM10.29840019
153CDK150.29549683

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030606.38248011
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.40342719
3Oxidative phosphorylation_Homo sapiens_hsa001903.59525853
4Proteasome_Homo sapiens_hsa030503.29413616
5Parkinsons disease_Homo sapiens_hsa050122.89301691
6Sulfur metabolism_Homo sapiens_hsa009202.84373393
7Graft-versus-host disease_Homo sapiens_hsa053322.40525410
8Autoimmune thyroid disease_Homo sapiens_hsa053202.32349668
9Folate biosynthesis_Homo sapiens_hsa007902.29141904
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.28349587
11Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.24527852
12Vibrio cholerae infection_Homo sapiens_hsa051102.23340007
13Ribosome_Homo sapiens_hsa030102.14879744
14Alzheimers disease_Homo sapiens_hsa050102.05707246
15N-Glycan biosynthesis_Homo sapiens_hsa005101.95004510
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.91612554
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.88104495
18Other glycan degradation_Homo sapiens_hsa005111.86939481
19Huntingtons disease_Homo sapiens_hsa050161.77156367
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.75922041
21Shigellosis_Homo sapiens_hsa051311.69832376
22Salmonella infection_Homo sapiens_hsa051321.57554189
23Collecting duct acid secretion_Homo sapiens_hsa049661.56789132
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.56531046
25RNA polymerase_Homo sapiens_hsa030201.49789760
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46973062
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.42790818
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.36607840
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.35964768
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35391086
31Galactose metabolism_Homo sapiens_hsa000521.33278414
32Viral myocarditis_Homo sapiens_hsa054161.31426360
33Fatty acid elongation_Homo sapiens_hsa000621.29915613
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28962012
35Leishmaniasis_Homo sapiens_hsa051401.25527615
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.23085451
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22219587
38Pyrimidine metabolism_Homo sapiens_hsa002401.18213285
39Lysosome_Homo sapiens_hsa041421.17692680
40Apoptosis_Homo sapiens_hsa042101.17646783
41Fructose and mannose metabolism_Homo sapiens_hsa000511.13919345
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13007941
43Regulation of autophagy_Homo sapiens_hsa041401.12412598
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11690782
45Osteoclast differentiation_Homo sapiens_hsa043801.11127316
46Asthma_Homo sapiens_hsa053101.08648397
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08220910
48Herpes simplex infection_Homo sapiens_hsa051681.06949967
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.06583076
50Measles_Homo sapiens_hsa051621.04308794
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.02955588
52Epstein-Barr virus infection_Homo sapiens_hsa051690.99683040
53Tuberculosis_Homo sapiens_hsa051520.99015462
54Hematopoietic cell lineage_Homo sapiens_hsa046400.98663059
55Acute myeloid leukemia_Homo sapiens_hsa052210.98627964
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95766837
57Type I diabetes mellitus_Homo sapiens_hsa049400.95506465
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.94811770
59Systemic lupus erythematosus_Homo sapiens_hsa053220.93994023
60Influenza A_Homo sapiens_hsa051640.93369483
61Pyruvate metabolism_Homo sapiens_hsa006200.90944624
62Sulfur relay system_Homo sapiens_hsa041220.90687786
63Histidine metabolism_Homo sapiens_hsa003400.89374752
64Staphylococcus aureus infection_Homo sapiens_hsa051500.88546935
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88035949
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.87723632
67Phenylalanine metabolism_Homo sapiens_hsa003600.86993660
68Metabolic pathways_Homo sapiens_hsa011000.86641939
69Rheumatoid arthritis_Homo sapiens_hsa053230.86292322
70African trypanosomiasis_Homo sapiens_hsa051430.85159031
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85060222
72Peroxisome_Homo sapiens_hsa041460.84196144
73Legionellosis_Homo sapiens_hsa051340.80763404
74Phagosome_Homo sapiens_hsa041450.80567645
75Pertussis_Homo sapiens_hsa051330.79685717
76Malaria_Homo sapiens_hsa051440.78769187
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.78512393
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77733442
79Purine metabolism_Homo sapiens_hsa002300.75960663
80Bladder cancer_Homo sapiens_hsa052190.74827903
81Glutathione metabolism_Homo sapiens_hsa004800.73673060
82Tyrosine metabolism_Homo sapiens_hsa003500.73337767
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72420702
84B cell receptor signaling pathway_Homo sapiens_hsa046620.71046523
85Arginine and proline metabolism_Homo sapiens_hsa003300.70857637
86Antigen processing and presentation_Homo sapiens_hsa046120.70389863
87Carbon metabolism_Homo sapiens_hsa012000.68568287
88Pentose phosphate pathway_Homo sapiens_hsa000300.68339593
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67925898
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67816825
91Sphingolipid metabolism_Homo sapiens_hsa006000.67644605
92T cell receptor signaling pathway_Homo sapiens_hsa046600.67418444
93Base excision repair_Homo sapiens_hsa034100.66975939
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66221207
95Toxoplasmosis_Homo sapiens_hsa051450.65886424
96Endocytosis_Homo sapiens_hsa041440.65214607
97Arachidonic acid metabolism_Homo sapiens_hsa005900.64999597
98TNF signaling pathway_Homo sapiens_hsa046680.64346305
99Hepatitis B_Homo sapiens_hsa051610.59005390
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57791150
101Selenocompound metabolism_Homo sapiens_hsa004500.56939962
102Starch and sucrose metabolism_Homo sapiens_hsa005000.56857032
103Tryptophan metabolism_Homo sapiens_hsa003800.55382871
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54959636
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54345431
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54344288
107Viral carcinogenesis_Homo sapiens_hsa052030.54053633
108DNA replication_Homo sapiens_hsa030300.53414779
109Insulin secretion_Homo sapiens_hsa049110.52656635
110Linoleic acid metabolism_Homo sapiens_hsa005910.52161644
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51656093
112Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51591607
113Synaptic vesicle cycle_Homo sapiens_hsa047210.50554894
114Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48275133
115Cardiac muscle contraction_Homo sapiens_hsa042600.47580275
116Steroid biosynthesis_Homo sapiens_hsa001000.47382890
117Hepatitis C_Homo sapiens_hsa051600.47274789
118Biosynthesis of amino acids_Homo sapiens_hsa012300.46232709
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.45500513
120Fat digestion and absorption_Homo sapiens_hsa049750.45497670
121Non-homologous end-joining_Homo sapiens_hsa034500.44866381
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.44309151
123HTLV-I infection_Homo sapiens_hsa051660.41323035
124Butanoate metabolism_Homo sapiens_hsa006500.40552419
125VEGF signaling pathway_Homo sapiens_hsa043700.39746747
126Pancreatic secretion_Homo sapiens_hsa049720.39733164
127Mismatch repair_Homo sapiens_hsa034300.38976503
128RNA degradation_Homo sapiens_hsa030180.38002740
129Intestinal immune network for IgA production_Homo sapiens_hsa046720.37116022
130Nucleotide excision repair_Homo sapiens_hsa034200.36604961
131Spliceosome_Homo sapiens_hsa030400.35319249
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34127545
133Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31806210
134Primary immunodeficiency_Homo sapiens_hsa053400.31451607
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31305723
136Propanoate metabolism_Homo sapiens_hsa006400.31286524
137Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31089521
138Chemical carcinogenesis_Homo sapiens_hsa052040.30211325
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30107949
140Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29995183
141Renin-angiotensin system_Homo sapiens_hsa046140.29871441
142Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29761251
143Homologous recombination_Homo sapiens_hsa034400.29434282
144Fatty acid degradation_Homo sapiens_hsa000710.27917370
145Prion diseases_Homo sapiens_hsa050200.26483771
146beta-Alanine metabolism_Homo sapiens_hsa004100.25922649
147Allograft rejection_Homo sapiens_hsa053300.24524959

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