| 1 | Abnormality of the labia minora (HP:0012880) | 3.64664598 |
| 2 | Birth length less than 3rd percentile (HP:0003561) | 3.26043199 |
| 3 | Increased serum pyruvate (HP:0003542) | 3.11708582 |
| 4 | Abnormality of glycolysis (HP:0004366) | 3.11708582 |
| 5 | Chromsome breakage (HP:0040012) | 3.10557455 |
| 6 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.08950569 |
| 7 | Ankle contracture (HP:0006466) | 2.99818230 |
| 8 | Premature rupture of membranes (HP:0001788) | 2.79490817 |
| 9 | Nemaline bodies (HP:0003798) | 2.78107681 |
| 10 | Abnormality of chromosome stability (HP:0003220) | 2.72362740 |
| 11 | Protrusio acetabuli (HP:0003179) | 2.67494749 |
| 12 | Insidious onset (HP:0003587) | 2.66760451 |
| 13 | Termporal pattern (HP:0011008) | 2.66760451 |
| 14 | Abnormal lung lobation (HP:0002101) | 2.65579720 |
| 15 | Breast hypoplasia (HP:0003187) | 2.61290828 |
| 16 | Papillary thyroid carcinoma (HP:0002895) | 2.57225422 |
| 17 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 2.53234892 |
| 18 | Muscle fiber inclusion bodies (HP:0100299) | 2.50332683 |
| 19 | Stenosis of the external auditory canal (HP:0000402) | 2.47871393 |
| 20 | Glossoptosis (HP:0000162) | 2.44909424 |
| 21 | Shoulder girdle muscle weakness (HP:0003547) | 2.44343394 |
| 22 | Abnormality of dentin (HP:0010299) | 2.42606556 |
| 23 | Abnormality of methionine metabolism (HP:0010901) | 2.40232192 |
| 24 | Neoplasm of the adrenal cortex (HP:0100641) | 2.33744552 |
| 25 | Abnormal auditory evoked potentials (HP:0006958) | 2.31505765 |
| 26 | Abnormal hair whorl (HP:0010721) | 2.29300479 |
| 27 | Abnormality of the anterior horn cell (HP:0006802) | 2.24594384 |
| 28 | Degeneration of anterior horn cells (HP:0002398) | 2.24594384 |
| 29 | Colon cancer (HP:0003003) | 2.23753253 |
| 30 | Hepatoblastoma (HP:0002884) | 2.23509884 |
| 31 | Neoplasm of the small intestine (HP:0100833) | 2.22733326 |
| 32 | Pelvic girdle muscle weakness (HP:0003749) | 2.22558183 |
| 33 | Hypoglycemic coma (HP:0001325) | 2.22126275 |
| 34 | Cystic hygroma (HP:0000476) | 2.20687620 |
| 35 | Abnormality of the calcaneus (HP:0008364) | 2.20190171 |
| 36 | Microglossia (HP:0000171) | 2.19292704 |
| 37 | Exercise-induced muscle cramps (HP:0003710) | 2.18917160 |
| 38 | Biliary tract neoplasm (HP:0100574) | 2.18328172 |
| 39 | Proximal tubulopathy (HP:0000114) | 2.17357242 |
| 40 | Abnormality of the lower motor neuron (HP:0002366) | 2.15104243 |
| 41 | Diastasis recti (HP:0001540) | 2.12014070 |
| 42 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.08210896 |
| 43 | Abnormality of the hip-girdle musculature (HP:0001445) | 2.07379942 |
| 44 | Abnormality of the musculature of the pelvis (HP:0001469) | 2.07379942 |
| 45 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.06574494 |
| 46 | Wormian bones (HP:0002645) | 2.06512532 |
| 47 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.06208346 |
| 48 | Aplasia/hypoplasia of the humerus (HP:0006507) | 2.05040864 |
| 49 | Short middle phalanx of the 5th finger (HP:0004220) | 2.03961040 |
| 50 | Wrist flexion contracture (HP:0001239) | 2.03437084 |
| 51 | Short humerus (HP:0005792) | 1.99744344 |
| 52 | Deviation of the thumb (HP:0009603) | 1.98936389 |
| 53 | Meckel diverticulum (HP:0002245) | 1.98122937 |
| 54 | Thyroid carcinoma (HP:0002890) | 1.98049964 |
| 55 | Ovarian neoplasm (HP:0100615) | 1.97141087 |
| 56 | Supernumerary spleens (HP:0009799) | 1.95264250 |
| 57 | Cerebral hypomyelination (HP:0006808) | 1.93602450 |
| 58 | Hypoplastic labia majora (HP:0000059) | 1.93349070 |
| 59 | Neoplasm of the adrenal gland (HP:0100631) | 1.91456109 |
| 60 | Abnormality of the ileum (HP:0001549) | 1.90738414 |
| 61 | Volvulus (HP:0002580) | 1.90542179 |
| 62 | Small intestinal stenosis (HP:0012848) | 1.88127815 |
| 63 | Duodenal stenosis (HP:0100867) | 1.88127815 |
| 64 | Amyotrophic lateral sclerosis (HP:0007354) | 1.87972476 |
| 65 | Calcaneovalgus deformity (HP:0001848) | 1.87720557 |
| 66 | Increased nuchal translucency (HP:0010880) | 1.87529240 |
| 67 | Deep philtrum (HP:0002002) | 1.87214375 |
| 68 | Distal arthrogryposis (HP:0005684) | 1.85576448 |
| 69 | Limb-girdle muscle atrophy (HP:0003797) | 1.85493099 |
| 70 | Soft skin (HP:0000977) | 1.85213857 |
| 71 | Ependymoma (HP:0002888) | 1.85149577 |
| 72 | Irregular epiphyses (HP:0010582) | 1.84915942 |
| 73 | Rhabdomyosarcoma (HP:0002859) | 1.84901992 |
| 74 | Mesomelia (HP:0003027) | 1.84844564 |
| 75 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.82573358 |
| 76 | Intestinal polyposis (HP:0200008) | 1.81768720 |
| 77 | Limb-girdle muscle weakness (HP:0003325) | 1.81615783 |
| 78 | Shallow orbits (HP:0000586) | 1.81594042 |
| 79 | Resting tremor (HP:0002322) | 1.81362708 |
| 80 | Neoplasm of the rectum (HP:0100743) | 1.81003022 |
| 81 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.80405050 |
| 82 | Carpal bone hypoplasia (HP:0001498) | 1.80231371 |
| 83 | Gonadotropin excess (HP:0000837) | 1.79916386 |
| 84 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.79844344 |
| 85 | Abnormality of alanine metabolism (HP:0010916) | 1.79844344 |
| 86 | Hyperalaninemia (HP:0003348) | 1.79844344 |
| 87 | Abnormality of the astrocytes (HP:0100707) | 1.78836875 |
| 88 | Astrocytoma (HP:0009592) | 1.78836875 |
| 89 | Long clavicles (HP:0000890) | 1.78704709 |
| 90 | Autoamputation (HP:0001218) | 1.77732935 |
| 91 | Deformed tarsal bones (HP:0008119) | 1.76789757 |
| 92 | Proximal placement of thumb (HP:0009623) | 1.76562963 |
| 93 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.76365602 |
| 94 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.76365602 |
| 95 | Abnormality of the preputium (HP:0100587) | 1.76063989 |
| 96 | Acute myeloid leukemia (HP:0004808) | 1.73978126 |
| 97 | Abnormality of the labia majora (HP:0012881) | 1.73286755 |
| 98 | Postnatal microcephaly (HP:0005484) | 1.73050389 |
| 99 | Abnormality of the duodenum (HP:0002246) | 1.71983297 |
| 100 | Delayed gross motor development (HP:0002194) | 1.71341126 |
| 101 | Spinal rigidity (HP:0003306) | 1.70439029 |
| 102 | Uterine neoplasm (HP:0010784) | 1.69772781 |
| 103 | Abnormality of the shoulder girdle musculature (HP:0001435) | 1.69165106 |
| 104 | Sloping forehead (HP:0000340) | 1.67699424 |
| 105 | Mild short stature (HP:0003502) | 1.67673266 |
| 106 | Cervical subluxation (HP:0003308) | 1.67262446 |
| 107 | Curly hair (HP:0002212) | 1.66475365 |
| 108 | Atresia of the external auditory canal (HP:0000413) | 1.66040398 |
| 109 | Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161) | 1.65924725 |
| 110 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.65605154 |
| 111 | Intestinal polyp (HP:0005266) | 1.65076617 |
| 112 | Abnormal pancreas size (HP:0012094) | 1.65004838 |
| 113 | Selective tooth agenesis (HP:0001592) | 1.64743605 |
| 114 | Neoplasm of the oral cavity (HP:0100649) | 1.63928414 |
| 115 | Abnormality of the distal phalanges of the toes (HP:0010182) | 1.63406983 |
| 116 | Abnormality of serum amino acid levels (HP:0003112) | 1.62958770 |
| 117 | Fused cervical vertebrae (HP:0002949) | 1.62919334 |
| 118 | Abnormal umbilical cord blood vessels (HP:0011403) | 1.62145183 |
| 119 | Single umbilical artery (HP:0001195) | 1.62145183 |
| 120 | Abnormality of the fetal cardiovascular system (HP:0010948) | 1.62145183 |
| 121 | Overgrowth (HP:0001548) | 1.62009355 |
| 122 | Embryonal renal neoplasm (HP:0011794) | 1.61696255 |
| 123 | Short 4th metacarpal (HP:0010044) | 1.61604015 |
| 124 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 1.61604015 |
| 125 | Abnormality of the septum pellucidum (HP:0007375) | 1.60300051 |
| 126 | Aplasia/Hypoplasia of the vertebrae (HP:0008515) | 1.59711133 |
| 127 | Vertebral hypoplasia (HP:0008417) | 1.59711133 |
| 128 | Reticulocytopenia (HP:0001896) | 1.59165137 |
| 129 | Adrenal hypoplasia (HP:0000835) | 1.59019020 |
| 130 | Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376) | 1.58433696 |
| 131 | Medulloblastoma (HP:0002885) | 1.58195631 |
| 132 | Increased hepatocellular lipid droplets (HP:0006565) | 1.57964654 |
| 133 | Absent septum pellucidum (HP:0001331) | 1.57685287 |
| 134 | Glioma (HP:0009733) | 1.57672352 |
| 135 | Synostosis of carpal bones (HP:0005048) | 1.57381362 |
| 136 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.56855765 |
| 137 | Myelodysplasia (HP:0002863) | 1.56057858 |
| 138 | Cortical dysplasia (HP:0002539) | 1.55877178 |
| 139 | Angiofibromas (HP:0010615) | 1.55505412 |
| 140 | Adenoma sebaceum (HP:0009720) | 1.55505412 |
| 141 | Neoplasm of the colon (HP:0100273) | 1.55239475 |
| 142 | Bifid tongue (HP:0010297) | 1.55196419 |
| 143 | Abnormal biliary tract morphology (HP:0012440) | 1.54553040 |
| 144 | Hypoglycemic seizures (HP:0002173) | 1.54552324 |
| 145 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 1.54262401 |
| 146 | Amniotic constriction ring (HP:0009775) | 1.54005299 |
| 147 | Abnormality of placental membranes (HP:0011409) | 1.54005299 |
| 148 | Short ribs (HP:0000773) | 1.53515167 |
| 149 | Patellar aplasia (HP:0006443) | 1.53151596 |
| 150 | Abnormality of the calf musculature (HP:0001430) | 1.52665705 |
| 151 | Progressive external ophthalmoplegia (HP:0000590) | 1.50807772 |
| 152 | Pheochromocytoma (HP:0002666) | 1.49969322 |
| 153 | Upper motor neuron abnormality (HP:0002127) | 1.49289932 |
| 154 | Reduced antithrombin III activity (HP:0001976) | 1.48922765 |
| 155 | Rimmed vacuoles (HP:0003805) | 1.48374447 |
| 156 | Hypoplastic pelvis (HP:0008839) | 1.47983026 |
| 157 | Neoplasm of striated muscle (HP:0009728) | 1.47028178 |
| 158 | Overlapping toe (HP:0001845) | 1.46152269 |
| 159 | Abnormality of the corticospinal tract (HP:0002492) | 1.46033598 |
| 160 | Gastrointestinal carcinoma (HP:0002672) | 1.45935435 |
| 161 | Malignant gastrointestinal tract tumors (HP:0006749) | 1.45935435 |
COPS2 
