COPS4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* cullin deneddylation (GO:0010388)5.04007107
2* protein deneddylation (GO:0000338)4.81673004
3proteasome assembly (GO:0043248)4.54138135
4negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.42428052
5positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.32279926
6regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.27828140
7purine nucleobase biosynthetic process (GO:0009113)4.26922067
8anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.24961469
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.10275261
10nucleobase biosynthetic process (GO:0046112)4.09528853
11negative regulation of ligase activity (GO:0051352)4.07752778
12negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.07752778
13mitotic metaphase plate congression (GO:0007080)3.99288660
14formation of translation preinitiation complex (GO:0001731)3.97389916
15CENP-A containing nucleosome assembly (GO:0034080)3.86006799
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.84660021
17DNA strand elongation involved in DNA replication (GO:0006271)3.83904457
18DNA replication checkpoint (GO:0000076)3.83130932
19DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.78998390
20regulation of cellular amino acid metabolic process (GO:0006521)3.78251396
21positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.76263791
227-methylguanosine mRNA capping (GO:0006370)3.73315443
23chromatin remodeling at centromere (GO:0031055)3.73147894
24telomere maintenance via semi-conservative replication (GO:0032201)3.72974750
25intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.72909480
26signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.72909480
27signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.72118293
28signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.72118293
29signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.72118293
30protein complex biogenesis (GO:0070271)3.71649168
31mitochondrial respiratory chain complex assembly (GO:0033108)3.69330788
32RNA capping (GO:0036260)3.68291607
337-methylguanosine RNA capping (GO:0009452)3.68291607
34energy coupled proton transport, down electrochemical gradient (GO:0015985)3.67329283
35ATP synthesis coupled proton transport (GO:0015986)3.67329283
36maturation of SSU-rRNA (GO:0030490)3.67211097
37ribosomal small subunit assembly (GO:0000028)3.64201773
38viral mRNA export from host cell nucleus (GO:0046784)3.62194412
39DNA strand elongation (GO:0022616)3.62102190
40signal transduction involved in DNA integrity checkpoint (GO:0072401)3.62024795
41signal transduction involved in DNA damage checkpoint (GO:0072422)3.62024795
42signal transduction involved in cell cycle checkpoint (GO:0072395)3.60232944
43spliceosomal snRNP assembly (GO:0000387)3.55881357
44DNA replication initiation (GO:0006270)3.55254199
45positive regulation of ligase activity (GO:0051351)3.55189409
46telomere maintenance via recombination (GO:0000722)3.54030862
47termination of RNA polymerase III transcription (GO:0006386)3.51669887
48transcription elongation from RNA polymerase III promoter (GO:0006385)3.51669887
49respiratory chain complex IV assembly (GO:0008535)3.49186067
50DNA deamination (GO:0045006)3.48077350
51metaphase plate congression (GO:0051310)3.43087052
52ribosome biogenesis (GO:0042254)3.42584924
53regulation of ubiquitin-protein transferase activity (GO:0051438)3.41483758
54RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.41195497
55tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.41195497
56DNA replication-dependent nucleosome assembly (GO:0006335)3.41051797
57DNA replication-dependent nucleosome organization (GO:0034723)3.41051797
58rRNA modification (GO:0000154)3.39749638
59DNA damage response, detection of DNA damage (GO:0042769)3.38255099
60mitotic recombination (GO:0006312)3.36214544
61establishment of protein localization to mitochondrial membrane (GO:0090151)3.35505329
62respiratory electron transport chain (GO:0022904)3.34174646
63histone exchange (GO:0043486)3.31703914
64protein neddylation (GO:0045116)3.31620937
65DNA ligation (GO:0006266)3.31470194
66maturation of 5.8S rRNA (GO:0000460)3.31047804
67L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.30661414
68DNA replication-independent nucleosome assembly (GO:0006336)3.30614266
69DNA replication-independent nucleosome organization (GO:0034724)3.30614266
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.29720573
71G1/S transition of mitotic cell cycle (GO:0000082)3.29436815
72cell cycle G1/S phase transition (GO:0044843)3.29436815
73nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.28845729
74transcription-coupled nucleotide-excision repair (GO:0006283)3.28270886
75ribonucleoprotein complex biogenesis (GO:0022613)3.27783810
76chaperone-mediated protein transport (GO:0072321)3.27708545
77electron transport chain (GO:0022900)3.26645187
78ribosome assembly (GO:0042255)3.26127566
79regulation of ligase activity (GO:0051340)3.25230982
80regulation of mitochondrial translation (GO:0070129)3.24882593
81organelle disassembly (GO:1903008)3.24663869
82ribosomal large subunit biogenesis (GO:0042273)3.22815678
83exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.22682261
84regulation of mitotic spindle checkpoint (GO:1903504)3.22476953
85regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.22476953
86establishment of integrated proviral latency (GO:0075713)3.20807171
87termination of RNA polymerase I transcription (GO:0006363)3.14353191
88rRNA processing (GO:0006364)3.13051397
89guanosine-containing compound biosynthetic process (GO:1901070)3.11847220
90transcription elongation from RNA polymerase I promoter (GO:0006362)3.11838334
91establishment of chromosome localization (GO:0051303)3.11719428
92DNA catabolic process, exonucleolytic (GO:0000738)3.11206729
93protein-cofactor linkage (GO:0018065)3.09041280
94telomere maintenance via telomere lengthening (GO:0010833)3.03888772
95ribosomal small subunit biogenesis (GO:0042274)3.03657368
96oxidative phosphorylation (GO:0006119)3.03475133
97cellular component biogenesis (GO:0044085)3.03380610
98mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.02894005
99mitochondrial respiratory chain complex I assembly (GO:0032981)3.02894005
100NADH dehydrogenase complex assembly (GO:0010257)3.02894005
101rRNA metabolic process (GO:0016072)3.02347582
102nucleotide-excision repair, DNA gap filling (GO:0006297)3.01880272
103negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.01869403
104negative regulation of sister chromatid segregation (GO:0033046)3.01869403
105negative regulation of mitotic sister chromatid separation (GO:2000816)3.01869403
106negative regulation of mitotic sister chromatid segregation (GO:0033048)3.01869403
107antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.01189877
108positive regulation of cell cycle arrest (GO:0071158)3.00900513
109DNA double-strand break processing (GO:0000729)2.98114410
110deoxyribonucleotide biosynthetic process (GO:0009263)2.97410364
111protein K11-linked ubiquitination (GO:0070979)2.97408102
112spliceosomal complex assembly (GO:0000245)2.96876101
113negative regulation of chromosome segregation (GO:0051985)2.95055168
114DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.94864786
115transcription from RNA polymerase I promoter (GO:0006360)2.94826874
116negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.94756128
117synapsis (GO:0007129)2.94720513
118rRNA methylation (GO:0031167)2.94304055
119negative regulation of DNA-dependent DNA replication (GO:2000104)2.92308134
120ubiquinone biosynthetic process (GO:0006744)2.92294263
121cytochrome complex assembly (GO:0017004)2.90390637
122ribonucleoprotein complex disassembly (GO:0032988)2.87929446
123ubiquinone metabolic process (GO:0006743)2.86849166
124branched-chain amino acid catabolic process (GO:0009083)2.86670936
125peptidyl-histidine modification (GO:0018202)2.84782442
126histone mRNA metabolic process (GO:0008334)2.84743888
127protein targeting to mitochondrion (GO:0006626)2.84734499
128establishment of viral latency (GO:0019043)2.84199597
129protein localization to mitochondrion (GO:0070585)2.82124013
130response to pheromone (GO:0019236)2.81390205
131regulation of meiosis I (GO:0060631)2.80419723
132intracellular protein transmembrane import (GO:0044743)2.78433507
133protein K6-linked ubiquitination (GO:0085020)2.78024912
134double-strand break repair via nonhomologous end joining (GO:0006303)2.76803665
135non-recombinational repair (GO:0000726)2.76803665
136water-soluble vitamin biosynthetic process (GO:0042364)2.76505133
137mannosylation (GO:0097502)2.71759409
138establishment of protein localization to mitochondrion (GO:0072655)2.69054318
139IMP biosynthetic process (GO:0006188)2.68646570
140mitochondrial RNA metabolic process (GO:0000959)2.67931938
141resolution of meiotic recombination intermediates (GO:0000712)2.67900064
142inner mitochondrial membrane organization (GO:0007007)2.67725054
143platelet dense granule organization (GO:0060155)2.67606105
144lactate metabolic process (GO:0006089)2.65451031
145histone H2A acetylation (GO:0043968)2.64045446
146replication fork processing (GO:0031297)2.63341885
147aldehyde catabolic process (GO:0046185)2.61102558

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.92625785
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.68114492
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.14755344
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.02669973
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.94183206
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.79199977
7* ETS1_20019798_ChIP-Seq_JURKAT_Human3.46424853
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.43891575
9* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.37976044
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.18952808
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.06910421
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.03375982
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.97219197
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.95115551
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.91833271
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.89167496
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.83426347
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79905733
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.75546148
20* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.69528617
21* VDR_23849224_ChIP-Seq_CD4+_Human2.66051073
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.63647575
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.51338106
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.44578615
25* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.37205038
26DCP1A_22483619_ChIP-Seq_HELA_Human2.34296368
27* XRN2_22483619_ChIP-Seq_HELA_Human2.33194570
28VDR_22108803_ChIP-Seq_LS180_Human2.28826360
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.26084013
30ZNF274_21170338_ChIP-Seq_K562_Hela2.24248992
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22588731
32* FOXP3_21729870_ChIP-Seq_TREG_Human2.21799559
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.21516028
34ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18222861
35POU3F2_20337985_ChIP-ChIP_501MEL_Human2.17768412
36* SRF_21415370_ChIP-Seq_HL-1_Mouse2.16895326
37GABP_19822575_ChIP-Seq_HepG2_Human2.12439064
38RBPJ_22232070_ChIP-Seq_NCS_Mouse2.10058801
39YY1_21170310_ChIP-Seq_MESCs_Mouse2.09145113
40TTF2_22483619_ChIP-Seq_HELA_Human2.05520449
41* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.04566807
42ELK1_19687146_ChIP-ChIP_HELA_Human2.04457004
43* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.04353992
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.02835902
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95807050
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.94934257
47IGF1R_20145208_ChIP-Seq_DFB_Human1.94014808
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93661231
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.92621653
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91633774
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.91318786
52AR_21909140_ChIP-Seq_LNCAP_Human1.91311609
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91258087
54FUS_26573619_Chip-Seq_HEK293_Human1.91208807
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80770295
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80589085
57* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70357190
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68182171
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62371451
60* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58307750
61TAF15_26573619_Chip-Seq_HEK293_Human1.51507923
62P300_19829295_ChIP-Seq_ESCs_Human1.50658886
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50545212
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.48293001
65* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46977725
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46082921
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41706014
68GBX2_23144817_ChIP-Seq_PC3_Human1.40469957
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39657127
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34714868
71* CIITA_25753668_ChIP-Seq_RAJI_Human1.31697348
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28213686
73* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.28046076
74* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27521541
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27466416
76KDM5A_27292631_Chip-Seq_BREAST_Human1.24743157
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24345997
78ELK1_22589737_ChIP-Seq_MCF10A_Human1.24319966
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22900120
80RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20360051
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17865652
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16598786
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16164105
84* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13543489
85EZH2_27294783_Chip-Seq_NPCs_Mouse1.13409206
86* MYC_18940864_ChIP-ChIP_HL60_Human1.12330230
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10848681
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08964808
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07871324
90SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07236183
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06745300
92CBP_20019798_ChIP-Seq_JUKART_Human1.06745300
93NFE2_27457419_Chip-Seq_LIVER_Mouse1.04568471
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02785391
95* NANOG_19829295_ChIP-Seq_ESCs_Human1.02555227
96* SOX2_19829295_ChIP-Seq_ESCs_Human1.02555227
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01731291
98TP53_22573176_ChIP-Seq_HFKS_Human1.01591116
99OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01260483
100* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01172603
101SALL1_21062744_ChIP-ChIP_HESCs_Human0.98678758
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98343860
103SOX17_20123909_ChIP-Seq_XEN_Mouse0.96843425
104E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96615327
105SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96581445
106KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96161730
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96132201
108ER_23166858_ChIP-Seq_MCF-7_Human0.95515943
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94470476
110PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93960574
111EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93955393
112* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93388423
113KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92978425
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92058333
115CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91650483
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91532103
117CRX_20693478_ChIP-Seq_RETINA_Mouse0.90796526
118TFEB_21752829_ChIP-Seq_HELA_Human0.89567048
119CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87546203
120TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87526060
121POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87005000
122SMAD4_21799915_ChIP-Seq_A2780_Human0.86243440
123IRF1_19129219_ChIP-ChIP_H3396_Human0.85334856
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85308819
125NOTCH1_21737748_ChIP-Seq_TLL_Human0.84302910
126TP63_19390658_ChIP-ChIP_HaCaT_Human0.83413144
127SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82165042
128NANOG_16153702_ChIP-ChIP_HESCs_Human0.82056374
129KLF4_18555785_ChIP-Seq_MESCs_Mouse0.79988332
130CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.75821709
131HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.74671921
132PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.73544958
133POU5F1_16153702_ChIP-ChIP_HESCs_Human0.72644424
134FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69537886
135EWS_26573619_Chip-Seq_HEK293_Human0.69508407
136SOX2_16153702_ChIP-ChIP_HESCs_Human0.68916719
137* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.67739483
138ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.65560268
139NANOG_21062744_ChIP-ChIP_HESCs_Human0.65379811
140GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.65031862
141* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.64437650
142SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.63651187

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.15990210
2MP0010094_abnormal_chromosome_stability4.15138299
3MP0004957_abnormal_blastocyst_morpholog4.13863484
4MP0008058_abnormal_DNA_repair3.56084369
5MP0003077_abnormal_cell_cycle3.47638787
6MP0003111_abnormal_nucleus_morphology3.44510632
7MP0003123_paternal_imprinting3.35957732
8MP0008877_abnormal_DNA_methylation3.13435816
9MP0008057_abnormal_DNA_replication2.97957255
10MP0008932_abnormal_embryonic_tissue2.86700419
11MP0009697_abnormal_copulation2.56947798
12MP0003718_maternal_effect2.55297388
13MP0008007_abnormal_cellular_replicative2.53262236
14MP0003121_genomic_imprinting2.25482036
15MP0003786_premature_aging2.14491713
16MP0001529_abnormal_vocalization2.05920467
17MP0003122_maternal_imprinting1.87252837
18MP0001730_embryonic_growth_arrest1.75735824
19MP0002160_abnormal_reproductive_system1.71079425
20MP0003646_muscle_fatigue1.66939001
21MP0003315_abnormal_perineum_morphology1.65096752
22MP0002210_abnormal_sex_determination1.61813522
23MP0000350_abnormal_cell_proliferation1.60114077
24MP0004215_abnormal_myocardial_fiber1.58458827
25MP0001984_abnormal_olfaction1.57627777
26MP0001929_abnormal_gametogenesis1.54054442
27MP0003806_abnormal_nucleotide_metabolis1.50959941
28MP0005503_abnormal_tendon_morphology1.50666963
29MP0005253_abnormal_eye_physiology1.49619033
30MP0001293_anophthalmia1.48533365
31MP0005410_abnormal_fertilization1.48484643
32MP0002234_abnormal_pharynx_morphology1.45023401
33MP0003195_calcinosis1.43634626
34MP0004084_abnormal_cardiac_muscle1.39866746
35MP0006036_abnormal_mitochondrial_physio1.39150850
36MP0002102_abnormal_ear_morphology1.36381824
37MP0001905_abnormal_dopamine_level1.34795415
38MP0001145_abnormal_male_reproductive1.33030734
39MP0005171_absent_coat_pigmentation1.32762113
40MP0005389_reproductive_system_phenotype1.30776629
41MP0002233_abnormal_nose_morphology1.28504136
42MP0002163_abnormal_gland_morphology1.28315326
43MP0001697_abnormal_embryo_size1.27161232
44MP0001672_abnormal_embryogenesis/_devel1.25451363
45MP0005380_embryogenesis_phenotype1.25451363
46MP0005551_abnormal_eye_electrophysiolog1.25316151
47MP0006035_abnormal_mitochondrial_morpho1.24657129
48MP0003937_abnormal_limbs/digits/tail_de1.24528510
49MP0009379_abnormal_foot_pigmentation1.23345563
50MP0009046_muscle_twitch1.21546330
51MP0000653_abnormal_sex_gland1.21494834
52MP0006276_abnormal_autonomic_nervous1.19153067
53MP0010030_abnormal_orbit_morphology1.18638208
54MP0003698_abnormal_male_reproductive1.18178154
55MP0005084_abnormal_gallbladder_morpholo1.17286067
56MP0004142_abnormal_muscle_tone1.16399443
57MP0003941_abnormal_skin_development1.16250321
58MP0002080_prenatal_lethality1.15179788
59MP0002090_abnormal_vision1.10963129
60MP0000358_abnormal_cell_content/1.10918769
61MP0000631_abnormal_neuroendocrine_gland1.09828640
62MP0003221_abnormal_cardiomyocyte_apopto1.09743754
63MP0008995_early_reproductive_senescence1.08731352
64MP0002938_white_spotting1.08483134
65MP0005645_abnormal_hypothalamus_physiol1.08338584
66MP0003011_delayed_dark_adaptation1.07783397
67MP0008260_abnormal_autophagy1.07771753
68MP0003984_embryonic_growth_retardation1.06669682
69MP0000313_abnormal_cell_death1.06523648
70MP0001919_abnormal_reproductive_system1.05334764
71MP0004233_abnormal_muscle_weight1.03237703
72MP0002638_abnormal_pupillary_reflex1.01921251
73MP0002272_abnormal_nervous_system1.01660574
74MP0002088_abnormal_embryonic_growth/wei1.01369187
75MP0002751_abnormal_autonomic_nervous1.01099476
76MP0001968_abnormal_touch/_nociception0.99822727
77MP0002396_abnormal_hematopoietic_system0.99795508
78MP0001485_abnormal_pinna_reflex0.99154278
79MP0000647_abnormal_sebaceous_gland0.98714467
80MP0003137_abnormal_impulse_conducting0.98342755
81MP0003567_abnormal_fetal_cardiomyocyte0.96889456
82MP0002085_abnormal_embryonic_tissue0.96761967
83MP0006292_abnormal_olfactory_placode0.95331767
84MP0000569_abnormal_digit_pigmentation0.95063823
85MP0004133_heterotaxia0.94431716
86MP0003787_abnormal_imprinting0.93479887
87MP0001188_hyperpigmentation0.92212829
88MP0003890_abnormal_embryonic-extraembry0.92005457
89MP0003186_abnormal_redox_activity0.90769767
90MP0004036_abnormal_muscle_relaxation0.89808930
91MP0008789_abnormal_olfactory_epithelium0.89064536
92MP0001727_abnormal_embryo_implantation0.88630487
93MP0005367_renal/urinary_system_phenotyp0.88103983
94MP0000516_abnormal_urinary_system0.88103983
95MP0000372_irregular_coat_pigmentation0.86550743
96MP0009745_abnormal_behavioral_response0.83676372
97MP0001486_abnormal_startle_reflex0.83160556
98MP0010386_abnormal_urinary_bladder0.82420488
99MP0002132_abnormal_respiratory_system0.82150696
100MP0010307_abnormal_tumor_latency0.81256178
101MP0009250_abnormal_appendicular_skeleto0.79901132
102MP0002161_abnormal_fertility/fecundity0.78942058
103MP0001119_abnormal_female_reproductive0.78180242
104MP0002127_abnormal_cardiovascular_syste0.78150701
105MP0003136_yellow_coat_color0.76461902
106MP0000537_abnormal_urethra_morphology0.76282789
107MP0001286_abnormal_eye_development0.74905738
108MP0000749_muscle_degeneration0.74454242
109MP0002084_abnormal_developmental_patter0.74130412
110MP0008872_abnormal_physiological_respon0.74048488
111MP0004145_abnormal_muscle_electrophysio0.73882323
112MP0003755_abnormal_palate_morphology0.73779586
113MP0005391_vision/eye_phenotype0.73435665
114MP0006072_abnormal_retinal_apoptosis0.72604822
115MP0002177_abnormal_outer_ear0.72428989
116MP0005187_abnormal_penis_morphology0.72056689
117MP0006054_spinal_hemorrhage0.71792388
118MP0002653_abnormal_ependyma_morphology0.71666444
119MP0002019_abnormal_tumor_incidence0.71656076
120MP0002277_abnormal_respiratory_mucosa0.71290904
121MP0003942_abnormal_urinary_system0.70606160
122MP0002734_abnormal_mechanical_nocicepti0.70443172
123MP0001986_abnormal_taste_sensitivity0.69368802
124MP0001764_abnormal_homeostasis0.68754190
125MP0004147_increased_porphyrin_level0.68201121
126MP0005266_abnormal_metabolism0.67675383
127MP0002736_abnormal_nociception_after0.65372482
128MP0004197_abnormal_fetal_growth/weight/0.65218003
129MP0002095_abnormal_skin_pigmentation0.65165102
130MP0001542_abnormal_bone_strength0.65151694
131MP0000049_abnormal_middle_ear0.64670749
132MP0005394_taste/olfaction_phenotype0.63046375
133MP0005499_abnormal_olfactory_system0.63046375
134MP0003119_abnormal_digestive_system0.62501224
135MP0005075_abnormal_melanosome_morpholog0.61653988
136MP0000490_abnormal_crypts_of0.61237007
137MP0003880_abnormal_central_pattern0.61162544
138MP0002837_dystrophic_cardiac_calcinosis0.59753303
139MP0005408_hypopigmentation0.58936080
140MP0002086_abnormal_extraembryonic_tissu0.58801571

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.74585320
2Acute necrotizing encephalopathy (HP:0006965)4.35261694
3Increased serum pyruvate (HP:0003542)4.13436478
4Abnormality of glycolysis (HP:0004366)4.13436478
5Abnormal mitochondria in muscle tissue (HP:0008316)3.96727237
6Mitochondrial inheritance (HP:0001427)3.80653680
7Increased CSF lactate (HP:0002490)3.63338631
8Hepatocellular necrosis (HP:0001404)3.47016577
9Progressive macrocephaly (HP:0004481)3.46356248
10Breast hypoplasia (HP:0003187)3.26011820
11Cerebral hypomyelination (HP:0006808)3.25024600
12Increased hepatocellular lipid droplets (HP:0006565)3.24034237
13Acute encephalopathy (HP:0006846)3.22044131
14Degeneration of anterior horn cells (HP:0002398)3.10691737
15Abnormality of the anterior horn cell (HP:0006802)3.10691737
16Irregular epiphyses (HP:0010582)3.02787508
17Hepatic necrosis (HP:0002605)2.97991189
18Hypoplasia of the capital femoral epiphysis (HP:0003090)2.95915906
19Increased serum lactate (HP:0002151)2.88251941
20Aplastic anemia (HP:0001915)2.85403201
213-Methylglutaconic aciduria (HP:0003535)2.83624868
22Reticulocytopenia (HP:0001896)2.81682951
23Lipid accumulation in hepatocytes (HP:0006561)2.80009447
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.75863041
25Decreased activity of mitochondrial respiratory chain (HP:0008972)2.75863041
26Respiratory difficulties (HP:0002880)2.75097346
27Patellar aplasia (HP:0006443)2.75086878
28Oral leukoplakia (HP:0002745)2.71876637
29Abnormality of the preputium (HP:0100587)2.70799726
30Exercise intolerance (HP:0003546)2.67156465
31Absent epiphyses (HP:0010577)2.64922296
32Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.64922296
33Type I transferrin isoform profile (HP:0003642)2.64255285
34Chromsome breakage (HP:0040012)2.62708059
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.62446968
36Abnormality of cells of the erythroid lineage (HP:0012130)2.60295260
37Aplasia/Hypoplasia of the patella (HP:0006498)2.59979665
38Abnormality of methionine metabolism (HP:0010901)2.58662466
39Carpal bone hypoplasia (HP:0001498)2.57612932
40Meckel diverticulum (HP:0002245)2.56689673
41Methylmalonic acidemia (HP:0002912)2.51093788
42Abnormality of the ileum (HP:0001549)2.50656055
43True hermaphroditism (HP:0010459)2.48584342
44Abnormal number of erythroid precursors (HP:0012131)2.47191830
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.46136263
46Optic disc pallor (HP:0000543)2.43855843
47Lactic acidosis (HP:0003128)2.43723212
48Molar tooth sign on MRI (HP:0002419)2.42272128
49Abnormality of midbrain morphology (HP:0002418)2.42272128
50Abnormality of aspartate family amino acid metabolism (HP:0010899)2.36225392
51Abnormal lung lobation (HP:0002101)2.33243951
52Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.31839152
53Abnormality of chromosome stability (HP:0003220)2.29092368
54Aplasia/Hypoplasia of the uvula (HP:0010293)2.27706411
55Rough bone trabeculation (HP:0100670)2.25584970
56Abnormality of alanine metabolism (HP:0010916)2.25203028
57Hyperalaninemia (HP:0003348)2.25203028
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25203028
59Unsteady gait (HP:0002317)2.20962388
60Hyperglycinemia (HP:0002154)2.20097276
61Embryonal renal neoplasm (HP:0011794)2.18948410
62Medial flaring of the eyebrow (HP:0010747)2.17755854
63Respiratory failure (HP:0002878)2.17167235
64Exercise-induced muscle cramps (HP:0003710)2.16134654
65Short tibia (HP:0005736)2.15471958
66Abnormality of the labia minora (HP:0012880)2.14365081
67Small intestinal stenosis (HP:0012848)2.14329329
68Duodenal stenosis (HP:0100867)2.14329329
69Agnosia (HP:0010524)2.12770161
70Exertional dyspnea (HP:0002875)2.12068700
71Pancreatic fibrosis (HP:0100732)2.11264699
72Shoulder girdle muscle weakness (HP:0003547)2.10869051
73Glossoptosis (HP:0000162)2.09826351
74Nemaline bodies (HP:0003798)2.08838934
75Abnormality of serum amino acid levels (HP:0003112)2.06617390
76Genital tract atresia (HP:0001827)2.06156654
77Congenital primary aphakia (HP:0007707)2.06091416
78Microvesicular hepatic steatosis (HP:0001414)2.05778931
79Methylmalonic aciduria (HP:0012120)2.04527863
80Secondary amenorrhea (HP:0000869)2.04437668
81Type 2 muscle fiber atrophy (HP:0003554)2.04411476
82Vaginal atresia (HP:0000148)2.03934902
83Nephroblastoma (Wilms tumor) (HP:0002667)2.03868121
84Selective tooth agenesis (HP:0001592)2.03473145
85Hypoplasia of the pons (HP:0012110)2.02175712
86Renal Fanconi syndrome (HP:0001994)2.01717908
87Hyperglycinuria (HP:0003108)2.00917847
88Macrocytic anemia (HP:0001972)2.00700006
89Atrophy/Degeneration involving motor neurons (HP:0007373)2.00476133
90Aplasia/Hypoplasia of the sternum (HP:0006714)2.00345693
91Nephrogenic diabetes insipidus (HP:0009806)2.00340852
92Medulloblastoma (HP:0002885)1.98142170
93Abnormal spermatogenesis (HP:0008669)1.96054048
94Lethargy (HP:0001254)1.95967234
95Aplasia/Hypoplasia of the tibia (HP:0005772)1.95881668
96Rimmed vacuoles (HP:0003805)1.94536617
97Abnormal biliary tract physiology (HP:0012439)1.94502147
98Bile duct proliferation (HP:0001408)1.94502147
99Facial cleft (HP:0002006)1.94451116
100Postnatal microcephaly (HP:0005484)1.94341704
101Nephronophthisis (HP:0000090)1.93730773
102CNS demyelination (HP:0007305)1.93283428
103Gait imbalance (HP:0002141)1.92161546
104CNS hypomyelination (HP:0003429)1.92055415
105Premature ovarian failure (HP:0008209)1.91823981
106Sloping forehead (HP:0000340)1.91731378
107Impulsivity (HP:0100710)1.91117658
108Reduced antithrombin III activity (HP:0001976)1.91116523
109Increased intramyocellular lipid droplets (HP:0012240)1.91020787
110Hypothermia (HP:0002045)1.89450567
111Supernumerary spleens (HP:0009799)1.89296372
112Absent thumb (HP:0009777)1.88978342
113Abnormality of the pons (HP:0007361)1.88166779
114Emotional lability (HP:0000712)1.87889398
115Pancreatic cysts (HP:0001737)1.85215543
116Cerebral edema (HP:0002181)1.84278909
117Microretrognathia (HP:0000308)1.84233203
118Abnormal protein glycosylation (HP:0012346)1.83921561
119Abnormal glycosylation (HP:0012345)1.83921561
120Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83921561
121Abnormal protein N-linked glycosylation (HP:0012347)1.83921561
122Leukodystrophy (HP:0002415)1.83298985
123Abnormality of serine family amino acid metabolism (HP:0010894)1.83276594
124Abnormality of glycine metabolism (HP:0010895)1.83276594
125Renal cortical cysts (HP:0000803)1.82722497
12611 pairs of ribs (HP:0000878)1.82463557
127Intestinal atresia (HP:0011100)1.81766089
128Muscle fiber inclusion bodies (HP:0100299)1.81359063
129Colon cancer (HP:0003003)1.80370258
130Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.78421402
131Stenosis of the external auditory canal (HP:0000402)1.76468785
132Aplasia/hypoplasia of the uterus (HP:0008684)1.75751241
133Aplasia/Hypoplasia of the tongue (HP:0010295)1.75555429
134Neoplasm of the adrenal gland (HP:0100631)1.73380937
135Increased muscle lipid content (HP:0009058)1.70497601
136Sclerocornea (HP:0000647)1.67805363
137Volvulus (HP:0002580)1.67725265
138X-linked dominant inheritance (HP:0001423)1.67108119
139Triphalangeal thumb (HP:0001199)1.65696397
140Poor suck (HP:0002033)1.65457002
141Bifid tongue (HP:0010297)1.63730162
142Muscle hypertrophy of the lower extremities (HP:0008968)1.63331448
143Median cleft lip (HP:0000161)1.62504880

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.60573281
2EIF2AK14.02377512
3TRIM283.69110792
4WEE13.50945530
5STK163.16213144
6TSSK62.90522594
7BRSK22.61100038
8CDC72.51831982
9EIF2AK32.48899982
10PLK42.41991880
11VRK12.26981487
12NME12.23420424
13SRPK12.10702937
14PLK32.07792945
15CCNB12.05391464
16NEK12.03065471
17MKNK12.01584143
18PDK31.97955701
19PDK41.97955701
20ACVR1B1.96639224
21FRK1.88981006
22BRSK11.82438398
23VRK21.76682930
24TTK1.75183725
25MAP4K21.70422000
26PLK11.69305076
27ZAK1.62315173
28AKT31.61217249
29NME21.54260665
30BCKDK1.49953610
31MKNK21.49638742
32BRAF1.49173350
33STK38L1.35995787
34PDK21.35106502
35PASK1.25476910
36AURKA1.24895997
37TESK11.18742487
38MAP3K121.18133948
39CSNK1G11.18059738
40AURKB1.15752397
41TNIK1.15084632
42TLK11.09959886
43NEK21.09662278
44CHEK21.06601406
45PINK11.06524065
46TAF11.06199099
47OXSR11.06154723
48ARAF1.05688688
49EPHA41.05418933
50BCR1.02619308
51MAP2K70.99760561
52CDK80.98012816
53LIMK10.97645211
54CSNK1G20.97045270
55MYLK0.96949487
56MINK10.96657833
57ATR0.96617893
58RPS6KB20.96507884
59OBSCN0.94050515
60SCYL20.93787916
61STK390.92979555
62BMPR1B0.92896421
63PLK20.92803193
64TESK20.91194527
65CSNK1A1L0.89126943
66CASK0.88049990
67GRK10.87131870
68DYRK30.86824412
69PIM20.84778353
70STK240.83292576
71PHKG10.78097847
72PHKG20.78097847
73EIF2AK20.77715711
74CDK70.75839034
75DYRK20.73843124
76ERBB30.73779607
77TGFBR10.72486455
78CSNK2A10.71680788
79PAK10.68302695
80CHEK10.66934563
81PNCK0.63395269
82PRKCG0.62999684
83MAPKAPK30.60525211
84MAPK130.59736004
85CSNK2A20.59653693
86YES10.58698256
87PAK30.58539904
88MST40.56117652
89PBK0.56080644
90EPHA20.53262132
91PRKCE0.53209391
92GRK70.50873783
93STK30.50546769
94ERBB40.49770486
95INSRR0.48340579
96MELK0.47617672
97NEK60.46371269
98ATM0.46309247
99PRKCI0.46122187
100KDR0.45667196
101BMPR20.45334048
102CAMK2A0.43425693
103ADRBK20.43169387
104PIK3CG0.42839985
105CDK10.42455794
106TIE10.41543499
107CDK180.40652536
108RPS6KA40.40094897
109RPS6KA50.39612995
110NLK0.39601688
111MARK10.39583790
112CDK20.39196132
113PAK40.38972784
114MUSK0.37385869
115ILK0.35473091
116CDK190.34097776
117DAPK10.34090433
118CDK140.33582855
119GRK50.33131976
120CDK11A0.32411134
121CDK150.32245277
122CDK30.32217416
123WNK30.31625720
124CSNK1G30.31208278
125RPS6KB10.30593091
126NUAK10.29611842
127MAP3K40.29542182
128SIK30.28357310
129PKN10.27826665
130CSNK1E0.27015111
131RAF10.26127774
132PIM10.25606061

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.96831200
2DNA replication_Homo sapiens_hsa030303.80778037
3RNA polymerase_Homo sapiens_hsa030203.72409279
4Mismatch repair_Homo sapiens_hsa034303.51389940
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.36900495
6Ribosome_Homo sapiens_hsa030103.31624188
7RNA transport_Homo sapiens_hsa030132.95544456
8Spliceosome_Homo sapiens_hsa030402.90294045
9Oxidative phosphorylation_Homo sapiens_hsa001902.72543125
10Nucleotide excision repair_Homo sapiens_hsa034202.68943391
11Pyrimidine metabolism_Homo sapiens_hsa002402.54678062
12Parkinsons disease_Homo sapiens_hsa050122.53036467
13Homologous recombination_Homo sapiens_hsa034402.52666160
14Base excision repair_Homo sapiens_hsa034102.45208065
15Basal transcription factors_Homo sapiens_hsa030222.33425489
16Cell cycle_Homo sapiens_hsa041102.30859526
17Protein export_Homo sapiens_hsa030602.28666484
18Huntingtons disease_Homo sapiens_hsa050162.10548594
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.99695803
20RNA degradation_Homo sapiens_hsa030181.90899439
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.90237863
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86445525
23Fanconi anemia pathway_Homo sapiens_hsa034601.86127855
24Non-homologous end-joining_Homo sapiens_hsa034501.75161095
25Purine metabolism_Homo sapiens_hsa002301.65575902
26Steroid biosynthesis_Homo sapiens_hsa001001.64171335
27Alzheimers disease_Homo sapiens_hsa050101.55005283
28One carbon pool by folate_Homo sapiens_hsa006701.52768527
29Butanoate metabolism_Homo sapiens_hsa006501.41375740
30Vitamin B6 metabolism_Homo sapiens_hsa007501.40095776
31mRNA surveillance pathway_Homo sapiens_hsa030151.34829604
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18358895
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13764615
34Epstein-Barr virus infection_Homo sapiens_hsa051691.12184261
35Oocyte meiosis_Homo sapiens_hsa041141.10352982
36Peroxisome_Homo sapiens_hsa041461.06694648
37p53 signaling pathway_Homo sapiens_hsa041151.01356643
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92215978
39Cardiac muscle contraction_Homo sapiens_hsa042600.92023920
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90865903
41Cysteine and methionine metabolism_Homo sapiens_hsa002700.90814142
42Fructose and mannose metabolism_Homo sapiens_hsa000510.87245025
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86842655
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84118154
45Fatty acid metabolism_Homo sapiens_hsa012120.81368146
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79615225
47Regulation of autophagy_Homo sapiens_hsa041400.77712935
48Carbon metabolism_Homo sapiens_hsa012000.74644783
49Collecting duct acid secretion_Homo sapiens_hsa049660.74410277
50Biosynthesis of amino acids_Homo sapiens_hsa012300.74246064
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73391730
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72634530
53Pyruvate metabolism_Homo sapiens_hsa006200.71688781
54Systemic lupus erythematosus_Homo sapiens_hsa053220.71401784
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69916035
56Vibrio cholerae infection_Homo sapiens_hsa051100.67645378
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67344050
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65427610
59beta-Alanine metabolism_Homo sapiens_hsa004100.63841160
60Nicotine addiction_Homo sapiens_hsa050330.63507338
61Pentose phosphate pathway_Homo sapiens_hsa000300.61067793
62Fatty acid degradation_Homo sapiens_hsa000710.60242914
63Folate biosynthesis_Homo sapiens_hsa007900.59825356
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59566245
65Glutathione metabolism_Homo sapiens_hsa004800.59524140
66Tryptophan metabolism_Homo sapiens_hsa003800.57054935
67Nitrogen metabolism_Homo sapiens_hsa009100.56969000
68Metabolic pathways_Homo sapiens_hsa011000.54889189
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54817212
70Alcoholism_Homo sapiens_hsa050340.51277143
71N-Glycan biosynthesis_Homo sapiens_hsa005100.50541798
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45098230
73Viral carcinogenesis_Homo sapiens_hsa052030.44811253
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.44554242
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43630069
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.41435574
77Arachidonic acid metabolism_Homo sapiens_hsa005900.41094496
78Antigen processing and presentation_Homo sapiens_hsa046120.39297446
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.39001208
80Galactose metabolism_Homo sapiens_hsa000520.36950192
81Taste transduction_Homo sapiens_hsa047420.36664473
82Caffeine metabolism_Homo sapiens_hsa002320.36175832
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35171074
84Sulfur relay system_Homo sapiens_hsa041220.34036868
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.32710138
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32386504
87Legionellosis_Homo sapiens_hsa051340.31051760
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30591830
89Olfactory transduction_Homo sapiens_hsa047400.30102612
90GABAergic synapse_Homo sapiens_hsa047270.29960586
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28864262
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28309557
93Chemical carcinogenesis_Homo sapiens_hsa052040.26497675
94Fatty acid elongation_Homo sapiens_hsa000620.26068620
95HTLV-I infection_Homo sapiens_hsa051660.22834273
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.21806299
97Herpes simplex infection_Homo sapiens_hsa051680.21254614
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.19491157
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19174234
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.17295599
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.16451697
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16236929
103Retinol metabolism_Homo sapiens_hsa008300.14510953
104Shigellosis_Homo sapiens_hsa051310.13451214
105Phagosome_Homo sapiens_hsa041450.13210039
106Arginine and proline metabolism_Homo sapiens_hsa003300.10965599
107Synaptic vesicle cycle_Homo sapiens_hsa047210.10841500
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.08871449
109Linoleic acid metabolism_Homo sapiens_hsa005910.08867975
110Circadian rhythm_Homo sapiens_hsa047100.08855594
111Propanoate metabolism_Homo sapiens_hsa006400.08788639
112Phototransduction_Homo sapiens_hsa047440.08206119
113Renin-angiotensin system_Homo sapiens_hsa046140.08153127
114Thyroid cancer_Homo sapiens_hsa052160.07365226
115Hippo signaling pathway_Homo sapiens_hsa043900.07268596
116TGF-beta signaling pathway_Homo sapiens_hsa043500.03992116
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.03946836
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.02337322
119Rheumatoid arthritis_Homo sapiens_hsa053230.01555855
120Colorectal cancer_Homo sapiens_hsa05210-2.6229274
121Autoimmune thyroid disease_Homo sapiens_hsa05320-0.0437624
122Sulfur metabolism_Homo sapiens_hsa00920-0.0435769
123Ether lipid metabolism_Homo sapiens_hsa00565-0.0268014
124Tyrosine metabolism_Homo sapiens_hsa00350-0.0199363
125Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.0157893
126Selenocompound metabolism_Homo sapiens_hsa00450-0.0033126
127Hedgehog signaling pathway_Homo sapiens_hsa04340-0.0009094
128HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0006384

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