COPS7B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.03910499
2proline biosynthetic process (GO:0006561)6.95895452
3replication fork processing (GO:0031297)6.15341225
4transcription from mitochondrial promoter (GO:0006390)5.96250492
5maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.39423733
6oxidative demethylation (GO:0070989)5.22099385
7proline metabolic process (GO:0006560)5.13691838
8regulation of mitochondrial translation (GO:0070129)5.02372958
9telomere maintenance via semi-conservative replication (GO:0032201)5.00526256
10embryonic process involved in female pregnancy (GO:0060136)4.93590128
11positive regulation of protein homooligomerization (GO:0032464)4.77033128
12viral mRNA export from host cell nucleus (GO:0046784)4.64982158
13DNA ligation (GO:0006266)4.64316929
14poly(A)+ mRNA export from nucleus (GO:0016973)4.46652398
15somatic hypermutation of immunoglobulin genes (GO:0016446)4.44009020
16somatic diversification of immune receptors via somatic mutation (GO:0002566)4.44009020
17kinetochore assembly (GO:0051382)4.40091234
18DNA strand renaturation (GO:0000733)4.37899796
19mitochondrial DNA metabolic process (GO:0032042)4.34270422
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.28189582
21mitochondrial respiratory chain complex I assembly (GO:0032981)4.27823373
22NADH dehydrogenase complex assembly (GO:0010257)4.27823373
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.27823373
24protein complex biogenesis (GO:0070271)4.27411261
25DNA integration (GO:0015074)4.26686831
26DNA damage response, detection of DNA damage (GO:0042769)4.20460137
27telomere maintenance via recombination (GO:0000722)4.19983565
28mitochondrial respiratory chain complex assembly (GO:0033108)4.19345871
29regulation of double-strand break repair via homologous recombination (GO:0010569)4.18317101
30nucleotide-excision repair, DNA gap filling (GO:0006297)4.16157636
31negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.12907459
32ribosomal small subunit assembly (GO:0000028)4.09813144
33DNA strand elongation involved in DNA replication (GO:0006271)4.09390681
34chaperone-mediated protein transport (GO:0072321)4.08758829
35mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.03147778
36negative regulation of mRNA processing (GO:0050686)3.92602649
37cotranslational protein targeting to membrane (GO:0006613)3.92581725
38termination of RNA polymerase III transcription (GO:0006386)3.90069581
39transcription elongation from RNA polymerase III promoter (GO:0006385)3.90069581
40DNA strand elongation (GO:0022616)3.87618040
41RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.86770129
42tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.86770129
43protein targeting to ER (GO:0045047)3.86568414
44base-excision repair (GO:0006284)3.86405222
45ATP synthesis coupled proton transport (GO:0015986)3.86401997
46energy coupled proton transport, down electrochemical gradient (GO:0015985)3.86401997
47protein-cofactor linkage (GO:0018065)3.86065475
48DNA double-strand break processing (GO:0000729)3.81764875
49pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.81686000
50negative regulation of cell cycle arrest (GO:0071157)3.77359277
51establishment of apical/basal cell polarity (GO:0035089)3.75259610
52kinetochore organization (GO:0051383)3.73645196
53regulation of integrin activation (GO:0033623)3.73097274
54DNA replication checkpoint (GO:0000076)3.72156190
55regulation of protein homooligomerization (GO:0032462)3.71642363
56termination of RNA polymerase II transcription (GO:0006369)3.67755168
57base-excision repair, AP site formation (GO:0006285)3.67663442
58viral transcription (GO:0019083)3.66357024
59negative regulation of JAK-STAT cascade (GO:0046426)3.64549068
60establishment of protein localization to endoplasmic reticulum (GO:0072599)3.64136327
61negative regulation of RNA splicing (GO:0033119)3.61937819
62protein localization to endoplasmic reticulum (GO:0070972)3.61395547
63telomere maintenance via telomere lengthening (GO:0010833)3.59488195
64maturation of 5.8S rRNA (GO:0000460)3.58973909
65mitotic recombination (GO:0006312)3.58727172
66respiratory electron transport chain (GO:0022904)3.58322891
67cellular protein complex disassembly (GO:0043624)3.57277354
68positive regulation of developmental pigmentation (GO:0048087)3.55589774
69electron transport chain (GO:0022900)3.55411906
70ubiquinone biosynthetic process (GO:0006744)3.53890561
71tRNA processing (GO:0008033)3.50573565
72meiotic chromosome segregation (GO:0045132)3.50296202
73double-strand break repair via nonhomologous end joining (GO:0006303)3.48644352
74non-recombinational repair (GO:0000726)3.48644352
75formation of translation preinitiation complex (GO:0001731)3.48561410
76positive regulation of DNA repair (GO:0045739)3.46304817
77behavioral response to nicotine (GO:0035095)3.45927695
78establishment of protein localization to mitochondrial membrane (GO:0090151)3.45351118
79peptidyl-histidine modification (GO:0018202)3.45085200
80translational termination (GO:0006415)3.43522795
81histone arginine methylation (GO:0034969)3.41292536
82cellular component biogenesis (GO:0044085)3.37488130
83pseudouridine synthesis (GO:0001522)3.36834302
84mitotic nuclear envelope reassembly (GO:0007084)3.36793977
85nuclear envelope reassembly (GO:0031468)3.36793977
86establishment of monopolar cell polarity (GO:0061162)3.36530440
87establishment or maintenance of monopolar cell polarity (GO:0061339)3.36530440
88translation (GO:0006412)3.35937220
89proteasome assembly (GO:0043248)3.35726041
90water-soluble vitamin biosynthetic process (GO:0042364)3.35311820
91viral life cycle (GO:0019058)3.33380392
92chromatin remodeling at centromere (GO:0031055)3.33022129
93regulation of double-strand break repair (GO:2000779)3.32029407
94histone H4-K12 acetylation (GO:0043983)3.30280157
95L-fucose catabolic process (GO:0042355)3.28064996
96fucose catabolic process (GO:0019317)3.28064996
97L-fucose metabolic process (GO:0042354)3.28064996
98negative regulation of telomere maintenance (GO:0032205)3.25440075
99metallo-sulfur cluster assembly (GO:0031163)3.24216885
100iron-sulfur cluster assembly (GO:0016226)3.24216885
101regulation of nuclear cell cycle DNA replication (GO:0033262)3.23167741
102nucleobase biosynthetic process (GO:0046112)3.22573450
103ncRNA processing (GO:0034470)3.22202738
104spliceosomal snRNP assembly (GO:0000387)3.22117734
105DNA demethylation (GO:0080111)3.21506284
106DNA replication-dependent nucleosome organization (GO:0034723)3.20505457
107DNA replication-dependent nucleosome assembly (GO:0006335)3.20505457
108ribosomal small subunit biogenesis (GO:0042274)3.20217380
109protein complex disassembly (GO:0043241)3.19594617
110platelet dense granule organization (GO:0060155)3.18600074
111ubiquinone metabolic process (GO:0006743)3.18584141
112translational initiation (GO:0006413)3.18383436
113mitochondrial DNA replication (GO:0006264)3.17240324
114face development (GO:0060324)3.16763982
115peptidyl-arginine omega-N-methylation (GO:0035247)3.15398356
116rRNA modification (GO:0000154)3.12996263
117L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.11190510
118cytochrome complex assembly (GO:0017004)3.09109803
119protein K6-linked ubiquitination (GO:0085020)3.08780067
120respiratory chain complex IV assembly (GO:0008535)3.08541999
121mitochondrial RNA metabolic process (GO:0000959)3.08051583
122histone H2A acetylation (GO:0043968)3.07295236
123mRNA cleavage (GO:0006379)3.07041092
124ncRNA metabolic process (GO:0034660)3.06593680
125maturation of SSU-rRNA (GO:0030490)3.06538839
126DNA dealkylation (GO:0035510)3.06023322
127heterochromatin organization (GO:0070828)3.06001898
128embryonic camera-type eye development (GO:0031076)3.04063271
129translational elongation (GO:0006414)3.03414366
130DNA replication initiation (GO:0006270)3.02746913
131DNA topological change (GO:0006265)3.02007086
132rRNA processing (GO:0006364)3.01573933
133macromolecular complex disassembly (GO:0032984)3.00768665
134negative regulation of mRNA metabolic process (GO:1903312)2.99466740
135GMP metabolic process (GO:0046037)2.99047701
136RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.98452890
137negative regulation of Ras GTPase activity (GO:0034261)2.98339944
138GDP-mannose metabolic process (GO:0019673)2.97709326
139exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.96908136
140nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.95553899
141piRNA metabolic process (GO:0034587)2.95448127
142positive regulation by host of viral transcription (GO:0043923)2.95341622
143CENP-A containing nucleosome assembly (GO:0034080)2.94731380
144protein targeting to mitochondrion (GO:0006626)2.93744834
145regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.93333825
146regulation of mitotic spindle checkpoint (GO:1903504)2.93333825
147spliceosomal tri-snRNP complex assembly (GO:0000244)2.92675671
148ribosomal large subunit biogenesis (GO:0042273)2.92593791
149cellular response to zinc ion (GO:0071294)2.91989156
150mitotic G1 DNA damage checkpoint (GO:0031571)2.91583104
151ncRNA 3-end processing (GO:0043628)2.89345272
152rRNA metabolic process (GO:0016072)2.88628363
153regulation of DNA repair (GO:0006282)2.88529189
154pyrimidine nucleotide catabolic process (GO:0006244)2.88450492
155cellular response to ATP (GO:0071318)2.87709774
156tRNA metabolic process (GO:0006399)2.87292113
157regulation of sister chromatid cohesion (GO:0007063)2.84180174
158deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.84099993
159response to pheromone (GO:0019236)2.83653759
160homocysteine metabolic process (GO:0050667)2.82849208
161tRNA methylation (GO:0030488)2.79464277
162tRNA modification (GO:0006400)2.79301599
163nuclear-transcribed mRNA catabolic process (GO:0000956)2.78171589
164ribosome biogenesis (GO:0042254)2.78160352
165convergent extension (GO:0060026)2.77832169
166nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.77668847
167SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.77591134
168establishment of protein localization to mitochondrion (GO:0072655)2.77478235
169histone exchange (GO:0043486)2.76990067
170ribonucleoprotein complex biogenesis (GO:0022613)2.76056938
171pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.76029968
172dosage compensation (GO:0007549)2.75092297
173regulation of stem cell maintenance (GO:2000036)2.73141595
174mismatch repair (GO:0006298)2.72114535
175single strand break repair (GO:0000012)2.71903402

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.69269605
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.17742193
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.21809355
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.21809355
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.21809355
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.16769618
7* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.99972657
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.98942580
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.94754884
10ZNF274_21170338_ChIP-Seq_K562_Hela2.76426166
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.76254322
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.72864437
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.67428442
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63160357
15ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.55615299
16RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.54625009
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.47222919
18* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.43680023
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.38194687
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.36468858
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.32341440
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.25584293
23YY1_21170310_ChIP-Seq_MESCs_Mouse2.23112759
24MYC_18940864_ChIP-ChIP_HL60_Human2.20221869
25FOXM1_23109430_ChIP-Seq_U2OS_Human2.18852586
26GABP_17652178_ChIP-ChIP_JURKAT_Human2.09299917
27EST1_17652178_ChIP-ChIP_JURKAT_Human2.07712506
28VDR_21846776_ChIP-Seq_THP-1_Human2.04745362
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03436706
30SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.01993536
31POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.00105375
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.98627853
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94720679
34CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.90678642
35* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.90611679
36* TTF2_22483619_ChIP-Seq_HELA_Human1.88893136
37TCF3_18692474_ChIP-Seq_MESCs_Mouse1.86269488
38XRN2_22483619_ChIP-Seq_HELA_Human1.85801008
39NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.85040700
40DCP1A_22483619_ChIP-Seq_HELA_Human1.84121967
41* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.82408683
42KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.81938349
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.80254074
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.76773834
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74937876
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.73827104
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72445042
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.70780070
49* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70421764
50TCF3_18692474_ChIP-Seq_MEFs_Mouse1.69403897
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65516925
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.65319362
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.64925128
54GABP_19822575_ChIP-Seq_HepG2_Human1.64701840
55CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.63811990
56* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63250080
57* VDR_23849224_ChIP-Seq_CD4+_Human1.62269485
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.59036570
59IRF1_19129219_ChIP-ChIP_H3396_Human1.58215630
60* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57866163
61KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.56114412
62CIITA_25753668_ChIP-Seq_RAJI_Human1.55570326
63* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.53818200
64POU5F1_16518401_ChIP-PET_MESCs_Mouse1.51556530
65ELK1_19687146_ChIP-ChIP_HELA_Human1.49144627
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.48696553
67* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.48395059
68* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48339690
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45193802
70PU.1_20513432_ChIP-Seq_Bcells_Mouse1.44493182
71* NANOG_21062744_ChIP-ChIP_HESCs_Human1.43153430
72NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42411535
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.38888477
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38210780
75E2F1_21310950_ChIP-Seq_MCF-7_Human1.36819128
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34416729
77* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33886525
78* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33860143
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31299870
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30428766
81TP53_22573176_ChIP-Seq_HFKS_Human1.29712830
82* FOXP3_21729870_ChIP-Seq_TREG_Human1.28757397
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.28427295
84* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.27507151
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.26694111
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24288208
87MYC_22102868_ChIP-Seq_BL_Human1.22727218
88ELF1_17652178_ChIP-ChIP_JURKAT_Human1.22357550
89TET1_21451524_ChIP-Seq_MESCs_Mouse1.22241250
90HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22085892
91EWS_26573619_Chip-Seq_HEK293_Human1.20743115
92FOXP1_21924763_ChIP-Seq_HESCs_Human1.20142230
93RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19334606
94NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18901009
95* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18686881
96* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18114356
97SOX2_18692474_ChIP-Seq_MEFs_Mouse1.18072998
98SRF_21415370_ChIP-Seq_HL-1_Mouse1.17844737
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16436115
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16201080
101SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.15234946
102YY1_22570637_ChIP-Seq_MALME-3M_Human1.15160845
103CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13052577
104HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12684449
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12518698
106STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11576169
107E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10593022
108POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09946215
109MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08994739
110EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08297338
111SOX2_18692474_ChIP-Seq_MESCs_Mouse1.08110811
112* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07162896
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06855033
114RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06791363
115YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06650600
116RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.05545968
117ERA_21632823_ChIP-Seq_H3396_Human1.04444847
118KDM5A_27292631_Chip-Seq_BREAST_Human1.03891716
119SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02061948
120ERG_21242973_ChIP-ChIP_JURKAT_Human1.01028443
121CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00691757
122* CREB1_15753290_ChIP-ChIP_HEK293T_Human0.99804989
123PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99342591
124BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98697742
125TAF2_19829295_ChIP-Seq_ESCs_Human0.96946751
126STAT1_20625510_ChIP-Seq_HELA_Human0.96875451
127NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.95644018
128* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.95478623
129SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95147477
130CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94929947
131SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94430021
132ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94171137
133IGF1R_20145208_ChIP-Seq_DFB_Human0.89310121
134CTCF_20526341_ChIP-Seq_ESCs_Human0.89158894
135FUS_26573619_Chip-Seq_HEK293_Human0.88749398
136GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88719841
137PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87556091
138EZH2_22144423_ChIP-Seq_EOC_Human0.87511688
139* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87510979
140PHF8_20622854_ChIP-Seq_HELA_Human0.85945321
141ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84382887
142VDR_22108803_ChIP-Seq_LS180_Human0.84263475
143NANOG_20526341_ChIP-Seq_ESCs_Human0.83566765
144MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83022201
145E2F1_20622854_ChIP-Seq_HELA_Human0.81614269
146BCL6_27268052_Chip-Seq_Bcells_Human0.81603115
147MYC_19829295_ChIP-Seq_ESCs_Human0.80927804

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.23507413
2MP0005171_absent_coat_pigmentation3.44954960
3MP0010030_abnormal_orbit_morphology3.43386540
4MP0003136_yellow_coat_color3.15675861
5MP0010094_abnormal_chromosome_stability3.06891640
6MP0005174_abnormal_tail_pigmentation2.93523773
7MP0008058_abnormal_DNA_repair2.63819699
8MP0006292_abnormal_olfactory_placode2.61624262
9MP0008995_early_reproductive_senescence2.60079572
10MP0009278_abnormal_bone_marrow2.58013605
11MP0002009_preneoplasia2.34146747
12MP0003111_abnormal_nucleus_morphology2.32262986
13MP0002102_abnormal_ear_morphology2.29627497
14MP0004957_abnormal_blastocyst_morpholog2.26990785
15MP0003786_premature_aging2.23769012
16MP0003693_abnormal_embryo_hatching2.22160645
17MP0000015_abnormal_ear_pigmentation2.18134956
18MP0006036_abnormal_mitochondrial_physio2.12516510
19MP0004133_heterotaxia2.11769429
20MP0002249_abnormal_larynx_morphology2.03556713
21MP0001529_abnormal_vocalization2.02013604
22MP0008932_abnormal_embryonic_tissue2.01564598
23MP0003890_abnormal_embryonic-extraembry1.97031688
24MP0003077_abnormal_cell_cycle1.93972820
25MP0006072_abnormal_retinal_apoptosis1.93617670
26MP0000490_abnormal_crypts_of1.88660653
27MP0002653_abnormal_ependyma_morphology1.86374242
28MP0003119_abnormal_digestive_system1.86135802
29MP0005551_abnormal_eye_electrophysiolog1.80677013
30MP0001188_hyperpigmentation1.76514631
31MP0005646_abnormal_pituitary_gland1.72274467
32MP0006035_abnormal_mitochondrial_morpho1.71678425
33MP0005075_abnormal_melanosome_morpholog1.71454479
34MP0003186_abnormal_redox_activity1.68528030
35MP0009379_abnormal_foot_pigmentation1.67493859
36MP0008007_abnormal_cellular_replicative1.65496563
37MP0002160_abnormal_reproductive_system1.63575836
38MP0001968_abnormal_touch/_nociception1.62507067
39MP0009697_abnormal_copulation1.61981660
40MP0000049_abnormal_middle_ear1.59028592
41MP0008875_abnormal_xenobiotic_pharmacok1.56020877
42MP0005379_endocrine/exocrine_gland_phen1.55704041
43MP0002736_abnormal_nociception_after1.50663668
44MP0003937_abnormal_limbs/digits/tail_de1.48589121
45MP0000631_abnormal_neuroendocrine_gland1.48546435
46MP0004043_abnormal_pH_regulation1.46261773
47MP0008877_abnormal_DNA_methylation1.45584830
48MP0005084_abnormal_gallbladder_morpholo1.44425116
49MP0002751_abnormal_autonomic_nervous1.42408498
50MP0002132_abnormal_respiratory_system1.41405299
51MP0001293_anophthalmia1.41270605
52MP0002282_abnormal_trachea_morphology1.38962838
53MP0004233_abnormal_muscle_weight1.37982222
54MP0000372_irregular_coat_pigmentation1.37868747
55MP0003195_calcinosis1.36805685
56MP0001905_abnormal_dopamine_level1.35472752
57MP0002085_abnormal_embryonic_tissue1.34746175
58MP0005410_abnormal_fertilization1.31121329
59MP0005397_hematopoietic_system_phenotyp1.29662858
60MP0001545_abnormal_hematopoietic_system1.29662858
61MP0003567_abnormal_fetal_cardiomyocyte1.27942102
62MP0005499_abnormal_olfactory_system1.27690662
63MP0005394_taste/olfaction_phenotype1.27690662
64MP0009333_abnormal_splenocyte_physiolog1.26632584
65MP0002938_white_spotting1.25698384
66MP0001697_abnormal_embryo_size1.23492724
67MP0000350_abnormal_cell_proliferation1.22176212
68MP0003122_maternal_imprinting1.21755626
69MP0002084_abnormal_developmental_patter1.21542510
70MP0008872_abnormal_physiological_respon1.20872036
71MP0009046_muscle_twitch1.20405638
72MP0009745_abnormal_behavioral_response1.17132857
73MP0005389_reproductive_system_phenotype1.16526529
74MP0003698_abnormal_male_reproductive1.15731704
75MP0000566_synostosis1.13195383
76MP0002234_abnormal_pharynx_morphology1.10290392
77MP0003938_abnormal_ear_development1.09083427
78MP0003718_maternal_effect1.08950960
79MP0002277_abnormal_respiratory_mucosa1.08416316
80MP0003941_abnormal_skin_development1.07578576
81MP0001340_abnormal_eyelid_morphology1.07373303
82MP0003755_abnormal_palate_morphology1.07364239
83MP0002638_abnormal_pupillary_reflex1.06561556
84MP0001986_abnormal_taste_sensitivity1.06397425
85MP0003385_abnormal_body_wall1.04522454
86MP0000470_abnormal_stomach_morphology1.03291053
87MP0002837_dystrophic_cardiac_calcinosis1.02186445
88MP0002932_abnormal_joint_morphology1.02167859
89MP0002111_abnormal_tail_morphology1.01284138
90MP0002086_abnormal_extraembryonic_tissu1.01270989
91MP0002210_abnormal_sex_determination1.00769745
92MP0002116_abnormal_craniofacial_bone1.00065692
93MP0005187_abnormal_penis_morphology0.99739169
94MP0000516_abnormal_urinary_system0.97676222
95MP0005367_renal/urinary_system_phenotyp0.97676222
96MP0002876_abnormal_thyroid_physiology0.97529017
97MP0001672_abnormal_embryogenesis/_devel0.97284626
98MP0005380_embryogenesis_phenotype0.97284626
99MP0004197_abnormal_fetal_growth/weight/0.97049850
100MP0004142_abnormal_muscle_tone0.96905367
101MP0004147_increased_porphyrin_level0.96031886
102MP0004381_abnormal_hair_follicle0.95943084
103MP0001145_abnormal_male_reproductive0.95914716
104MP0003880_abnormal_central_pattern0.95748233
105MP0002114_abnormal_axial_skeleton0.95604524
106MP0001502_abnormal_circadian_rhythm0.95313253
107MP0002272_abnormal_nervous_system0.94629892
108MP0000579_abnormal_nail_morphology0.93668407
109MP0002019_abnormal_tumor_incidence0.93602745
110MP0000762_abnormal_tongue_morphology0.91812564
111MP0002177_abnormal_outer_ear0.91694934
112MP0005377_hearing/vestibular/ear_phenot0.91578122
113MP0003878_abnormal_ear_physiology0.91578122
114MP0000462_abnormal_digestive_system0.89305143
115MP0003283_abnormal_digestive_organ0.88767905
116MP0006276_abnormal_autonomic_nervous0.88623464
117MP0000371_diluted_coat_color0.88409594
118MP0002075_abnormal_coat/hair_pigmentati0.88319580
119MP0003646_muscle_fatigue0.85458966
120MP0002095_abnormal_skin_pigmentation0.85275784
121MP0000432_abnormal_head_morphology0.85266464
122MP0005076_abnormal_cell_differentiation0.84367645
123MP0000313_abnormal_cell_death0.84130392
124MP0003935_abnormal_craniofacial_develop0.83684670
125MP0002080_prenatal_lethality0.83383796
126MP0003121_genomic_imprinting0.83268997
127MP0003861_abnormal_nervous_system0.83162908
128MP0001186_pigmentation_phenotype0.82607802
129MP0003828_pulmonary_edema0.81896059
130MP0005195_abnormal_posterior_eye0.81670131
131MP0001286_abnormal_eye_development0.81609312
132MP0008789_abnormal_olfactory_epithelium0.81386345
133MP0002161_abnormal_fertility/fecundity0.79714387
134MP0003137_abnormal_impulse_conducting0.79613784
135MP0005645_abnormal_hypothalamus_physiol0.78756524
136MP0001485_abnormal_pinna_reflex0.77681888
137MP0005391_vision/eye_phenotype0.77305442
138MP0000778_abnormal_nervous_system0.77249668
139MP0005253_abnormal_eye_physiology0.76923048
140MP0001730_embryonic_growth_arrest0.76649313
141MP0000681_abnormal_thyroid_gland0.76543249
142MP0000678_abnormal_parathyroid_gland0.76226430
143MP0001324_abnormal_eye_pigmentation0.75744189
144MP0000653_abnormal_sex_gland0.75586485
145MP0009672_abnormal_birth_weight0.74882736
146MP0003763_abnormal_thymus_physiology0.74578012
147MP0002557_abnormal_social/conspecific_i0.74420655
148MP0001919_abnormal_reproductive_system0.74103030
149MP0001119_abnormal_female_reproductive0.74063565
150MP0004145_abnormal_muscle_electrophysio0.73706175
151MP0001881_abnormal_mammary_gland0.73594461
152MP0003315_abnormal_perineum_morphology0.73090601
153MP0002163_abnormal_gland_morphology0.72796369
154MP0002752_abnormal_somatic_nervous0.71204655
155MP0009250_abnormal_appendicular_skeleto0.71109477
156MP0001929_abnormal_gametogenesis0.70891195
157MP0000647_abnormal_sebaceous_gland0.69940611
158MP0003936_abnormal_reproductive_system0.69734022

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)5.45946705
2Rectovaginal fistula (HP:0000143)4.19865980
3Rectal fistula (HP:0100590)4.19865980
4Rib fusion (HP:0000902)4.18296490
5Acute necrotizing encephalopathy (HP:0006965)3.87340275
6Intestinal fistula (HP:0100819)3.82420104
7Absent thumb (HP:0009777)3.73160767
8Facial hemangioma (HP:0000329)3.67343679
9Increased IgM level (HP:0003496)3.63750235
10Acute encephalopathy (HP:0006846)3.56665109
11Absent radius (HP:0003974)3.55338748
12Abnormal mitochondria in muscle tissue (HP:0008316)3.53324217
13Vaginal fistula (HP:0004320)3.53246973
14Intestinal atresia (HP:0011100)3.46736259
15Aplasia involving forearm bones (HP:0009822)3.43674574
16Absent forearm bone (HP:0003953)3.43674574
17Annular pancreas (HP:0001734)3.41920865
18Patellar aplasia (HP:0006443)3.40361785
19Abnormal hemoglobin (HP:0011902)3.40331924
20Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.37108519
21Abnormality of alanine metabolism (HP:0010916)3.37108519
22Hyperalaninemia (HP:0003348)3.37108519
23Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.35119571
24Poikiloderma (HP:0001029)3.34097435
25Mitochondrial inheritance (HP:0001427)3.33890713
26Hepatocellular necrosis (HP:0001404)3.25630093
27Increased CSF lactate (HP:0002490)3.24266560
283-Methylglutaconic aciduria (HP:0003535)3.21404885
29Aplasia/Hypoplasia of the patella (HP:0006498)3.18751081
30Hypoplasia of the radius (HP:0002984)3.16891945
31Hepatic necrosis (HP:0002605)3.15308860
32Abnormality of the ileum (HP:0001549)3.13472439
33Pustule (HP:0200039)3.07594085
34Progressive macrocephaly (HP:0004481)3.04496470
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.98000049
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.98000049
37Reticulocytopenia (HP:0001896)2.95359160
38Premature graying of hair (HP:0002216)2.87075292
39Colon cancer (HP:0003003)2.86720508
40Increased serum lactate (HP:0002151)2.84487664
41Pancreatic cysts (HP:0001737)2.84203139
42Fibular aplasia (HP:0002990)2.82525401
43Type II lissencephaly (HP:0007260)2.80890972
44Aplasia/Hypoplasia of the sacrum (HP:0008517)2.80663031
45Alacrima (HP:0000522)2.80193483
46Abnormality of midbrain morphology (HP:0002418)2.80162650
47Molar tooth sign on MRI (HP:0002419)2.80162650
48Tongue fasciculations (HP:0001308)2.77219827
49Hyperglycinemia (HP:0002154)2.76421297
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.76365261
51Abnormal number of incisors (HP:0011064)2.72904878
52Delayed CNS myelination (HP:0002188)2.71751784
53Coronal craniosynostosis (HP:0004440)2.70661564
54Abnormality of male internal genitalia (HP:0000022)2.69789406
55Lipid accumulation in hepatocytes (HP:0006561)2.68378977
56Pendular nystagmus (HP:0012043)2.67977124
57Supernumerary spleens (HP:0009799)2.66425633
58Cleft eyelid (HP:0000625)2.65263750
59Sex reversal (HP:0012245)2.62906488
60Abnormal sex determination (HP:0012244)2.62906488
61Increased hepatocellular lipid droplets (HP:0006565)2.61787277
62Congenital stationary night blindness (HP:0007642)2.61729866
63Aplasia/hypoplasia of the humerus (HP:0006507)2.59596134
64Hypoplasia of the pons (HP:0012110)2.58764413
65Muscle fiber atrophy (HP:0100295)2.57865871
66Capillary hemangiomas (HP:0005306)2.54980311
67Selective tooth agenesis (HP:0001592)2.51382871
68Short chin (HP:0000331)2.50344814
69Aplasia/hypoplasia of the uterus (HP:0008684)2.48523159
70Anteriorly placed anus (HP:0001545)2.48045366
71Lactic acidosis (HP:0003128)2.46224711
72Acute lymphatic leukemia (HP:0006721)2.46114861
73Abnormality of abdominal situs (HP:0011620)2.45343544
74Abdominal situs inversus (HP:0003363)2.45343544
75Abnormality of the pons (HP:0007361)2.44008585
76Aplasia/Hypoplasia of the uvula (HP:0010293)2.43419310
77Abnormality of the labia minora (HP:0012880)2.42445753
78Amelogenesis imperfecta (HP:0000705)2.41668591
79Squamous cell carcinoma (HP:0002860)2.41449003
80Chromosomal breakage induced by crosslinking agents (HP:0003221)2.38174885
81Short humerus (HP:0005792)2.36134144
82Decreased lacrimation (HP:0000633)2.35636413
83Muscle fibrillation (HP:0010546)2.34612807
84Type 2 muscle fiber atrophy (HP:0003554)2.34579467
85Exertional dyspnea (HP:0002875)2.34162868
86Aplasia of the musculature (HP:0100854)2.33905982
87Broad alveolar ridges (HP:0000187)2.33601908
88Aplastic anemia (HP:0001915)2.30897099
89Meckel diverticulum (HP:0002245)2.30428843
90Short thumb (HP:0009778)2.29237027
91Albinism (HP:0001022)2.29155982
92Adactyly (HP:0009776)2.27767690
93Basal cell carcinoma (HP:0002671)2.27195899
94Hypomagnesemia (HP:0002917)2.25447306
95Abnormality of the aortic arch (HP:0012303)2.25194348
96Abnormality of the middle phalanges of the toes (HP:0010183)2.22718528
97Orthostatic hypotension (HP:0001278)2.22382104
98Retinal dysplasia (HP:0007973)2.21911603
99Abnormality of the preputium (HP:0100587)2.21119731
100Abolished electroretinogram (ERG) (HP:0000550)2.20750026
101Bifid uvula (HP:0000193)2.20319688
102Increased number of teeth (HP:0011069)2.18940675
103Breast hypoplasia (HP:0003187)2.18480459
104Progressive microcephaly (HP:0000253)2.17727274
105Type I transferrin isoform profile (HP:0003642)2.16898203
106Microretrognathia (HP:0000308)2.16412295
107Congenital hip dislocation (HP:0001374)2.15015757
108Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.13981441
109Pancreatic fibrosis (HP:0100732)2.11990266
110Cerebral edema (HP:0002181)2.11826061
111Abnormal respiratory epithelium morphology (HP:0012253)2.10317447
112Abnormal respiratory motile cilium morphology (HP:0005938)2.10317447
113Increased intramyocellular lipid droplets (HP:0012240)2.08852554
114Triphalangeal thumb (HP:0001199)2.08608833
115Testicular atrophy (HP:0000029)2.08015125
116Hyperglycinuria (HP:0003108)2.07723158
117Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.06932915
118Methylmalonic aciduria (HP:0012120)2.06686181
119Median cleft lip (HP:0000161)2.06045595
120Chromsome breakage (HP:0040012)2.05955465
121Abnormality of cells of the erythroid lineage (HP:0012130)2.05408725
122Optic disc pallor (HP:0000543)2.05233398
123True hermaphroditism (HP:0010459)2.03775869
124Chorioretinal atrophy (HP:0000533)2.03696906
125Anencephaly (HP:0002323)2.03624624
126Abnormal number of erythroid precursors (HP:0012131)2.03595468
127Methylmalonic acidemia (HP:0002912)2.03172268
128Abnormality of the phalanges of the 2nd finger (HP:0009541)2.02794003
129Renal Fanconi syndrome (HP:0001994)2.02700902
130Volvulus (HP:0002580)2.01761513
131Opisthotonus (HP:0002179)2.01583733
132Alopecia of scalp (HP:0002293)2.01383012
133Anal atresia (HP:0002023)2.00914516
134Vertebral hypoplasia (HP:0008417)2.00407070
135Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.00407070
136Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.99657075
137Humeroradial synostosis (HP:0003041)1.98614107
138Synostosis involving the elbow (HP:0003938)1.98614107
139Bilateral microphthalmos (HP:0007633)1.98398520
140Turricephaly (HP:0000262)1.98371831
141Hypochromic microcytic anemia (HP:0004840)1.96480931
142Small hand (HP:0200055)1.95537318
143Abnormality of the phalanges of the 5th finger (HP:0004213)1.94576877
144Hypotelorism (HP:0000601)1.94276591
145Gastrointestinal atresia (HP:0002589)1.94273901
146Occipital encephalocele (HP:0002085)1.93966543
147Bile duct proliferation (HP:0001408)1.93285188
148Abnormal biliary tract physiology (HP:0012439)1.93285188
149Abnormality of magnesium homeostasis (HP:0004921)1.93154749
150Increased muscle lipid content (HP:0009058)1.92666123
151Abnormality of serum amino acid levels (HP:0003112)1.92167358
152Abnormality of the anterior horn cell (HP:0006802)1.91718393
153Degeneration of anterior horn cells (HP:0002398)1.91718393
154Forearm undergrowth (HP:0009821)1.91534692
155Abnormality of the renal cortex (HP:0011035)1.91391529
156Decreased electroretinogram (ERG) amplitude (HP:0000654)1.91024996
157Male infertility (HP:0003251)1.91001385
158Septo-optic dysplasia (HP:0100842)1.90962629
159Microvesicular hepatic steatosis (HP:0001414)1.90446291
160Exercise intolerance (HP:0003546)1.89890322
161Cheilitis (HP:0100825)1.89810464
162Abnormality of serine family amino acid metabolism (HP:0010894)1.89186398
163Abnormality of glycine metabolism (HP:0010895)1.89186398
164Hypoplasia of the uterus (HP:0000013)1.87956613
165Optic nerve hypoplasia (HP:0000609)1.87606379
166Aplasia/Hypoplasia involving the musculature (HP:0001460)1.86269526
167Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.85848018
168Hypoplasia of the ulna (HP:0003022)1.85771927
169Ulnar bowing (HP:0003031)1.85080209
170Respiratory failure (HP:0002878)1.83397948
171Pallor (HP:0000980)1.83208841
172Birth length less than 3rd percentile (HP:0003561)1.82898175
173Duplicated collecting system (HP:0000081)1.82274639
174Nephronophthisis (HP:0000090)1.80706105
175Sclerocornea (HP:0000647)1.80452287
176Short tibia (HP:0005736)1.80398456
177Hypochromic anemia (HP:0001931)1.80175508
178Nephroblastoma (Wilms tumor) (HP:0002667)1.79284372
179Lethargy (HP:0001254)1.78732499
180Macrocytic anemia (HP:0001972)1.78272446
181Symphalangism affecting the phalanges of the hand (HP:0009773)1.78129715
182Severe visual impairment (HP:0001141)1.77423731
183Cerebral hypomyelination (HP:0006808)1.75704416
184Choanal stenosis (HP:0000452)1.74657201

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.46082553
2MAPK154.07770463
3ZAK3.65725113
4MAP3K63.47866506
5DDR23.47231517
6VRK23.06309747
7MAP4K23.06006928
8MAP3K113.00491221
9UHMK12.68449074
10YES12.63702740
11PRKD22.62343195
12BCKDK2.58859892
13MATK2.53345800
14FGR2.50582694
15TLK12.30154643
16PINK12.26890922
17PLK42.24486177
18PIM22.23919470
19WNK42.12597786
20PRPF4B2.11201085
21NME12.10378427
22CDK72.07558592
23CASK2.05576606
24DYRK32.02380480
25MKNK21.93981872
26DAPK11.90309327
27WNK31.88447212
28BUB11.88408348
29PDK21.87284010
30CSK1.80626147
31DYRK1B1.76447463
32CLK11.74238741
33GRK11.71959045
34NME21.69593617
35TYRO31.67894609
36NUAK11.66568239
37TIE11.57745542
38SRPK11.56932866
39INSRR1.53700242
40TNIK1.50487320
41PIM11.47300509
42BMPR1B1.47042459
43AKT31.46056964
44MKNK11.35051896
45KDR1.32895744
46BMX1.31623535
47CHEK21.28953118
48TRIM281.27956702
49TSSK61.26711911
50STK161.25027958
51RPS6KC11.24003471
52RPS6KL11.24003471
53DYRK21.23459578
54WEE11.22381447
55FLT31.21767135
56PLK11.21587150
57IRAK41.18719912
58TAOK21.07556680
59PLK31.06490459
60RPS6KA61.05372938
61RPS6KA50.98879653
62CSNK1G30.98450613
63HIPK20.96508019
64NEK10.95130039
65EIF2AK10.94363470
66CDC70.92760998
67TAF10.90853222
68TGFBR10.89361194
69ATR0.87401174
70AURKA0.85239554
71PDGFRA0.84637810
72CDK60.84414634
73TRPM70.83592872
74MAPK110.82005912
75RPS6KA40.81201970
76VRK10.80384066
77TESK20.77136841
78KIT0.77098109
79CDK80.75162052
80TXK0.75055063
81LATS20.72616215
82CDC42BPA0.71863982
83IRAK30.69615496
84CSNK1G20.65954128
85FRK0.65203331
86GSK3A0.64937084
87CSNK2A10.64767151
88MAPK130.62809749
89CSNK1G10.61975330
90MAP2K20.61513846
91MAPKAPK50.61008452
92AURKB0.58382018
93RPS6KA10.57500538
94MARK30.57264173
95LYN0.57016691
96NEK20.55945800
97MAP2K60.55422123
98OXSR10.55074873
99EIF2AK30.54923816
100CSNK1A1L0.54405702
101PRKCG0.53240214
102CDK20.51947805
103CAMK2B0.51715416
104MUSK0.49778982
105CSNK2A20.49727136
106ITK0.49365545
107STK380.48436437
108PHKG10.48262442
109PHKG20.48262442
110CSNK1E0.43269576
111MAP3K40.42434497
112DAPK20.42347071
113MAPK40.42044266
114CHEK10.41500468
115NLK0.41461031
116MAP3K90.41418199
117ERBB30.41189309
118ATM0.40862145
119RPS6KB20.40323915
120NTRK20.40234799
121ADRBK10.39900648
122CDK30.37280230
123STK40.36663468
124PAK10.36073740
125MAP4K10.35659956
126CSNK1A10.35436153
127CCNB10.35318518
128ARAF0.34743887
129TNK20.34156889
130CDK10.33928675
131PNCK0.33924558
132CDK190.32591056
133SIK30.32469534
134CDK40.31469089
135BRSK10.31251916
136CAMK2A0.31226656
137CSNK1D0.30098952
138EIF2AK20.29881644
139ACVR1B0.29687601
140TAOK30.29110375
141CAMK10.28966068
142PASK0.28903364
143TTK0.27240128
144MAPKAPK20.27231075
145ADRBK20.27098243
146PRKAA10.27047814
147BRSK20.26528203
148MAPK140.25722706
149RPS6KB10.25175226
150ABL20.24830550
151IKBKB0.23850487
152AKT10.22653578
153PRKCI0.22249650
154MAPK30.22114095
155MAPK10.20595274
156MAPK100.20154148
157AKT20.19958950

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.75666837
2DNA replication_Homo sapiens_hsa030304.66290818
3Base excision repair_Homo sapiens_hsa034104.16824764
4Ribosome_Homo sapiens_hsa030103.63708845
5Spliceosome_Homo sapiens_hsa030403.22046534
6Homologous recombination_Homo sapiens_hsa034402.99077940
7Fanconi anemia pathway_Homo sapiens_hsa034602.82180976
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.79405877
9Nucleotide excision repair_Homo sapiens_hsa034202.77996141
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.51474838
11RNA transport_Homo sapiens_hsa030132.22245388
12RNA polymerase_Homo sapiens_hsa030202.19856144
13Fatty acid biosynthesis_Homo sapiens_hsa000612.10398652
14mRNA surveillance pathway_Homo sapiens_hsa030152.08204407
15Cell cycle_Homo sapiens_hsa041101.95518671
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.89980743
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.82836272
18Selenocompound metabolism_Homo sapiens_hsa004501.79119545
19p53 signaling pathway_Homo sapiens_hsa041151.73617925
20Alzheimers disease_Homo sapiens_hsa050101.64075568
21Basal transcription factors_Homo sapiens_hsa030221.62217463
22Pyrimidine metabolism_Homo sapiens_hsa002401.61826464
23One carbon pool by folate_Homo sapiens_hsa006701.61777533
24Basal cell carcinoma_Homo sapiens_hsa052171.60145804
25Notch signaling pathway_Homo sapiens_hsa043301.58384241
26Hedgehog signaling pathway_Homo sapiens_hsa043401.56000138
27Proteasome_Homo sapiens_hsa030501.45965393
28Linoleic acid metabolism_Homo sapiens_hsa005911.42686095
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.41925664
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39500209
31Sulfur relay system_Homo sapiens_hsa041221.38455672
32Hippo signaling pathway_Homo sapiens_hsa043901.32895379
33Wnt signaling pathway_Homo sapiens_hsa043101.31752777
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.25878074
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.22957822
36RNA degradation_Homo sapiens_hsa030181.20328601
37Circadian rhythm_Homo sapiens_hsa047101.19034810
38Primary immunodeficiency_Homo sapiens_hsa053401.15466006
39Cardiac muscle contraction_Homo sapiens_hsa042601.15167333
40Non-homologous end-joining_Homo sapiens_hsa034501.12918168
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10990063
42Folate biosynthesis_Homo sapiens_hsa007901.09529430
43Ether lipid metabolism_Homo sapiens_hsa005651.09460528
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04203683
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04132644
46Thyroid cancer_Homo sapiens_hsa052160.99138661
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98025722
48Pyruvate metabolism_Homo sapiens_hsa006200.97081579
49Arginine and proline metabolism_Homo sapiens_hsa003300.95935424
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95401412
51Fatty acid elongation_Homo sapiens_hsa000620.91932927
52Asthma_Homo sapiens_hsa053100.89028029
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86503979
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85916695
55TGF-beta signaling pathway_Homo sapiens_hsa043500.84046276
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82797507
57Colorectal cancer_Homo sapiens_hsa052100.82283097
58Nitrogen metabolism_Homo sapiens_hsa009100.81560906
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81490940
60Shigellosis_Homo sapiens_hsa051310.80859928
61Nicotine addiction_Homo sapiens_hsa050330.80081262
62Oocyte meiosis_Homo sapiens_hsa041140.76798127
63Herpes simplex infection_Homo sapiens_hsa051680.76068435
64Epstein-Barr virus infection_Homo sapiens_hsa051690.73726144
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73687130
66Butanoate metabolism_Homo sapiens_hsa006500.72935894
67Purine metabolism_Homo sapiens_hsa002300.72494490
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71801797
69Adherens junction_Homo sapiens_hsa045200.71700156
70Bladder cancer_Homo sapiens_hsa052190.71443304
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70900410
72Huntingtons disease_Homo sapiens_hsa050160.70522186
73Vitamin B6 metabolism_Homo sapiens_hsa007500.67583395
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.67376057
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67163002
76MicroRNAs in cancer_Homo sapiens_hsa052060.67107317
77Propanoate metabolism_Homo sapiens_hsa006400.66297957
78Peroxisome_Homo sapiens_hsa041460.65074412
79Sulfur metabolism_Homo sapiens_hsa009200.60431619
80Autoimmune thyroid disease_Homo sapiens_hsa053200.59129510
81Regulation of autophagy_Homo sapiens_hsa041400.58557000
82Tryptophan metabolism_Homo sapiens_hsa003800.57877846
83Type I diabetes mellitus_Homo sapiens_hsa049400.57350674
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.56544517
85HTLV-I infection_Homo sapiens_hsa051660.50735019
86Parkinsons disease_Homo sapiens_hsa050120.49328082
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48926272
88Acute myeloid leukemia_Homo sapiens_hsa052210.48231614
89Oxidative phosphorylation_Homo sapiens_hsa001900.47475313
90Caffeine metabolism_Homo sapiens_hsa002320.46689985
91Viral carcinogenesis_Homo sapiens_hsa052030.45836234
92Lysine degradation_Homo sapiens_hsa003100.44558809
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.44346983
94beta-Alanine metabolism_Homo sapiens_hsa004100.44122373
95Protein export_Homo sapiens_hsa030600.43588547
96Measles_Homo sapiens_hsa051620.43141691
97mTOR signaling pathway_Homo sapiens_hsa041500.42890297
98Biosynthesis of amino acids_Homo sapiens_hsa012300.41860323
99Fat digestion and absorption_Homo sapiens_hsa049750.41822111
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38792289
101Phototransduction_Homo sapiens_hsa047440.38534952
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.38168424
103Arachidonic acid metabolism_Homo sapiens_hsa005900.38008243
104Tyrosine metabolism_Homo sapiens_hsa003500.37835971
105Olfactory transduction_Homo sapiens_hsa047400.37691414
106Legionellosis_Homo sapiens_hsa051340.37015879
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36078531
108Viral myocarditis_Homo sapiens_hsa054160.35487054
109Pathways in cancer_Homo sapiens_hsa052000.35319147
110Hepatitis B_Homo sapiens_hsa051610.35178015
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34849516
112Taste transduction_Homo sapiens_hsa047420.32624218
113Glutathione metabolism_Homo sapiens_hsa004800.31800757
114Systemic lupus erythematosus_Homo sapiens_hsa053220.31328335
115Small cell lung cancer_Homo sapiens_hsa052220.29560692
116Collecting duct acid secretion_Homo sapiens_hsa049660.28959260
117Prostate cancer_Homo sapiens_hsa052150.28302841
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26823367
119Antigen processing and presentation_Homo sapiens_hsa046120.26558781
120Tight junction_Homo sapiens_hsa045300.25048007
121Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23654652
122Steroid biosynthesis_Homo sapiens_hsa001000.23023080
123Endometrial cancer_Homo sapiens_hsa052130.22532975
124Ovarian steroidogenesis_Homo sapiens_hsa049130.22321651
125Carbon metabolism_Homo sapiens_hsa012000.22122866
126Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21837344
127Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21778724
128Fatty acid metabolism_Homo sapiens_hsa012120.21245034
129ErbB signaling pathway_Homo sapiens_hsa040120.20769550
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.20751254
131N-Glycan biosynthesis_Homo sapiens_hsa005100.20372270
132RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.19934879
133VEGF signaling pathway_Homo sapiens_hsa043700.19335704
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.18929107
135Vitamin digestion and absorption_Homo sapiens_hsa049770.18731706
136Graft-versus-host disease_Homo sapiens_hsa053320.18156264
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17119030
138Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16546020
139Chemical carcinogenesis_Homo sapiens_hsa052040.16329688
140Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.16190150
141Chronic myeloid leukemia_Homo sapiens_hsa052200.16164405
142Gap junction_Homo sapiens_hsa045400.16075561
143Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.15153171
144Metabolic pathways_Homo sapiens_hsa011000.14353955
145Melanogenesis_Homo sapiens_hsa049160.14337512
146Glycosaminoglycan degradation_Homo sapiens_hsa005310.14155359
147Allograft rejection_Homo sapiens_hsa053300.13966126
148Fructose and mannose metabolism_Homo sapiens_hsa000510.13949555
149MAPK signaling pathway_Homo sapiens_hsa040100.12920501

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