COPS8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* cullin deneddylation (GO:0010388)5.63179597
2* protein deneddylation (GO:0000338)5.46448157
3proteasome assembly (GO:0043248)4.95239672
4negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.20095783
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.12899422
6positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.01951768
7chromatin remodeling at centromere (GO:0031055)4.00454734
8anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.97601737
9CENP-A containing nucleosome assembly (GO:0034080)3.96964151
10regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.96815363
11energy coupled proton transport, down electrochemical gradient (GO:0015985)3.90356914
12ATP synthesis coupled proton transport (GO:0015986)3.90356914
13negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.87549080
14negative regulation of ligase activity (GO:0051352)3.87549080
157-methylguanosine mRNA capping (GO:0006370)3.78954436
16chaperone-mediated protein transport (GO:0072321)3.71358624
17RNA capping (GO:0036260)3.70224486
187-methylguanosine RNA capping (GO:0009452)3.70224486
19formation of translation preinitiation complex (GO:0001731)3.62389605
20protein neddylation (GO:0045116)3.61472490
21positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.60863031
22regulation of cellular amino acid metabolic process (GO:0006521)3.47748719
23DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.45765983
24histone exchange (GO:0043486)3.44162517
25maturation of 5.8S rRNA (GO:0000460)3.42182998
26transcription elongation from RNA polymerase III promoter (GO:0006385)3.41883924
27termination of RNA polymerase III transcription (GO:0006386)3.41883924
28positive regulation of ligase activity (GO:0051351)3.41017814
29signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.40001697
30intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.40001697
31signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.38779571
32signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.38779571
33signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.38779571
34tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.35253023
35RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.35253023
36histone arginine methylation (GO:0034969)3.30554039
37signal transduction involved in DNA damage checkpoint (GO:0072422)3.29816463
38signal transduction involved in DNA integrity checkpoint (GO:0072401)3.29816463
39maturation of SSU-rRNA (GO:0030490)3.29056818
40regulation of ubiquitin-protein transferase activity (GO:0051438)3.27868362
41protein complex biogenesis (GO:0070271)3.26807864
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.26587697
43mitochondrial respiratory chain complex I assembly (GO:0032981)3.26587697
44NADH dehydrogenase complex assembly (GO:0010257)3.26587697
45peptidyl-arginine omega-N-methylation (GO:0035247)3.26463541
46signal transduction involved in cell cycle checkpoint (GO:0072395)3.26286157
47viral mRNA export from host cell nucleus (GO:0046784)3.22067485
48L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.21891451
49spliceosomal snRNP assembly (GO:0000387)3.21875635
50DNA replication checkpoint (GO:0000076)3.21219368
51respiratory chain complex IV assembly (GO:0008535)3.18490197
52histone H2A acetylation (GO:0043968)3.17553798
53DNA ligation (GO:0006266)3.17359311
54regulation of ligase activity (GO:0051340)3.12575002
55establishment of protein localization to mitochondrion (GO:0072655)3.08983063
56de novo protein folding (GO:0006458)3.08939250
57establishment of protein localization to mitochondrial membrane (GO:0090151)3.07369497
58regulation of mitochondrial translation (GO:0070129)3.07177827
59protein targeting to mitochondrion (GO:0006626)3.06806684
60ribosome biogenesis (GO:0042254)3.05591847
61protein localization to kinetochore (GO:0034501)3.03951741
62mitochondrial respiratory chain complex assembly (GO:0033108)3.03752338
63de novo posttranslational protein folding (GO:0051084)3.02925276
64metaphase plate congression (GO:0051310)3.02164273
65mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.99676838
66antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.99046510
67mitotic metaphase plate congression (GO:0007080)2.97517149
68protein localization to mitochondrion (GO:0070585)2.95983298
69nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93764232
70regulation of meiosis I (GO:0060631)2.93435622
71DNA damage response, detection of DNA damage (GO:0042769)2.93241902
72exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.92430506
73protein K11-linked ubiquitination (GO:0070979)2.92240801
74transcription-coupled nucleotide-excision repair (GO:0006283)2.91724932
75water-soluble vitamin biosynthetic process (GO:0042364)2.90650432
76protein-cofactor linkage (GO:0018065)2.89675576
77DNA strand elongation involved in DNA replication (GO:0006271)2.87326263
78respiratory electron transport chain (GO:0022904)2.85746442
79DNA replication-independent nucleosome assembly (GO:0006336)2.85715113
80DNA replication-independent nucleosome organization (GO:0034724)2.85715113
81DNA catabolic process, exonucleolytic (GO:0000738)2.85020700
82peptidyl-arginine methylation (GO:0018216)2.83203408
83peptidyl-arginine N-methylation (GO:0035246)2.83203408
84cell cycle G1/S phase transition (GO:0044843)2.82976825
85G1/S transition of mitotic cell cycle (GO:0000082)2.82976825
86spliceosomal complex assembly (GO:0000245)2.81400340
87rRNA modification (GO:0000154)2.80728612
88electron transport chain (GO:0022900)2.79837579
89transcription elongation from RNA polymerase I promoter (GO:0006362)2.78759859
90spindle checkpoint (GO:0031577)2.78464652
91heart contraction (GO:0060047)2.78201400
92heart process (GO:0003015)2.78201400
93termination of RNA polymerase I transcription (GO:0006363)2.78005468
94DNA strand elongation (GO:0022616)2.76353939
95oxidative phosphorylation (GO:0006119)2.76051029
96negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.75622656
97positive regulation of cell cycle arrest (GO:0071158)2.74996955
98regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.74367555
99regulation of mitotic spindle checkpoint (GO:1903504)2.74367555
100transcription elongation from RNA polymerase II promoter (GO:0006368)2.73915160
101mitotic spindle assembly checkpoint (GO:0007094)2.73263686
102negative regulation of mitotic sister chromatid segregation (GO:0033048)2.72816121
103negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.72816121
104negative regulation of sister chromatid segregation (GO:0033046)2.72816121
105negative regulation of mitotic sister chromatid separation (GO:2000816)2.72816121
106antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.72615985
107establishment of integrated proviral latency (GO:0075713)2.70727950
108deoxyribonucleotide biosynthetic process (GO:0009263)2.69845269
109protein K6-linked ubiquitination (GO:0085020)2.68963037
110DNA replication initiation (GO:0006270)2.68555178
111negative regulation of chromosome segregation (GO:0051985)2.67492744
112telomere maintenance via semi-conservative replication (GO:0032201)2.67455393
113DNA double-strand break processing (GO:0000729)2.66881649
114deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.66791223
115guanosine-containing compound biosynthetic process (GO:1901070)2.66356051
116nucleobase biosynthetic process (GO:0046112)2.65789892
117spindle assembly checkpoint (GO:0071173)2.65482974
118nucleobase-containing small molecule interconversion (GO:0015949)2.65182830
119piRNA metabolic process (GO:0034587)2.65151290
120cytochrome complex assembly (GO:0017004)2.64707774
121mitotic spindle checkpoint (GO:0071174)2.64329818
122attachment of spindle microtubules to kinetochore (GO:0008608)2.63068610
123kinetochore assembly (GO:0051382)2.62859855
124negative regulation of DNA-dependent DNA replication (GO:2000104)2.61585395
125kinetochore organization (GO:0051383)2.61356732
126establishment of viral latency (GO:0019043)2.59522095
127DNA replication-dependent nucleosome assembly (GO:0006335)2.58923011
128DNA replication-dependent nucleosome organization (GO:0034723)2.58923011
129replication fork processing (GO:0031297)2.58874961
130regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.58483642
131postreplication repair (GO:0006301)2.57273862
132synapsis (GO:0007129)2.55556038
133positive regulation of mitochondrial fission (GO:0090141)2.55402178
134negative regulation of DNA recombination (GO:0045910)2.54425783
135lactate metabolic process (GO:0006089)2.53529267
136platelet dense granule organization (GO:0060155)2.53096629
137nucleotide-excision repair, DNA gap filling (GO:0006297)2.53069324
138organelle disassembly (GO:1903008)2.52161088
139ribosome assembly (GO:0042255)2.52145530
140establishment of chromosome localization (GO:0051303)2.49854329
141retinal cone cell development (GO:0046549)2.49467266
142histone mRNA metabolic process (GO:0008334)2.49013447
143double-strand break repair via nonhomologous end joining (GO:0006303)2.47548419
144non-recombinational repair (GO:0000726)2.47548419
145protein heterotetramerization (GO:0051290)2.46774157

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.79538469
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.17211218
3* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.12555912
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.00660288
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.98533829
6E2F7_22180533_ChIP-Seq_HELA_Human3.90026222
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.89720539
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.64587978
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.47821022
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.45619938
11* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.34028932
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.08622987
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.91174024
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.88457223
15* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.85345888
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.71139971
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69081283
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.65200186
19VDR_23849224_ChIP-Seq_CD4+_Human2.49017753
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.47333526
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.38862964
22XRN2_22483619_ChIP-Seq_HELA_Human2.29632679
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.29486772
24GBX2_23144817_ChIP-Seq_PC3_Human2.29418084
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.26676600
26* GABP_19822575_ChIP-Seq_HepG2_Human2.24881180
27DCP1A_22483619_ChIP-Seq_HELA_Human2.24534276
28POU3F2_20337985_ChIP-ChIP_501MEL_Human2.24083330
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.23945936
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22207122
31SALL1_21062744_ChIP-ChIP_HESCs_Human2.21549816
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.18614158
33TTF2_22483619_ChIP-Seq_HELA_Human2.17252439
34FOXP3_21729870_ChIP-Seq_TREG_Human2.11685149
35YY1_21170310_ChIP-Seq_MESCs_Mouse2.10918476
36ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10246924
37RBPJ_22232070_ChIP-Seq_NCS_Mouse2.09532166
38ZNF274_21170338_ChIP-Seq_K562_Hela2.06601923
39* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05678410
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.03468301
41EWS_26573619_Chip-Seq_HEK293_Human2.02668770
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.98914676
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96637473
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.95046726
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.92608279
46ELK1_19687146_ChIP-ChIP_HELA_Human1.92427824
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.91447775
48TAF15_26573619_Chip-Seq_HEK293_Human1.81336948
49P300_19829295_ChIP-Seq_ESCs_Human1.77279207
50FOXM1_23109430_ChIP-Seq_U2OS_Human1.76116924
51IGF1R_20145208_ChIP-Seq_DFB_Human1.70913489
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68810090
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68296464
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67356169
55* VDR_22108803_ChIP-Seq_LS180_Human1.60235155
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56526612
57* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55561665
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.51939315
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51132000
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49710446
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.49650101
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48892319
63* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48498399
64AR_21909140_ChIP-Seq_LNCAP_Human1.42079100
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41773630
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40836300
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37200486
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.37092957
69MYC_18940864_ChIP-ChIP_HL60_Human1.36384234
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34312569
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33791552
72CIITA_25753668_ChIP-Seq_RAJI_Human1.33371374
73SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.33026283
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31776377
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29488281
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.28795818
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28191337
78* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26529678
79DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.25389968
80* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24367260
81* EZH2_27294783_Chip-Seq_NPCs_Mouse1.23334569
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23290393
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22509328
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19155529
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17948300
86* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14604865
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14566778
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14091659
89SMAD4_21799915_ChIP-Seq_A2780_Human1.13393502
90* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13259221
91E2F1_21310950_ChIP-Seq_MCF-7_Human1.12460641
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12231281
93CBP_20019798_ChIP-Seq_JUKART_Human1.12231281
94HTT_18923047_ChIP-ChIP_STHdh_Human1.10285076
95KDM5A_27292631_Chip-Seq_BREAST_Human1.10088730
96* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09347610
97SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09311264
98* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06682372
99NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06567802
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06456802
101* NFE2_27457419_Chip-Seq_LIVER_Mouse1.04327748
102* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03757799
103* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03695975
104SMAD3_21741376_ChIP-Seq_EPCs_Human1.03493816
105PIAS1_25552417_ChIP-Seq_VCAP_Human1.03441906
106CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03127230
107* NANOG_18555785_Chip-Seq_ESCs_Mouse1.02773015
108CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.00981209
109NANOG_19829295_ChIP-Seq_ESCs_Human0.99697084
110SOX2_19829295_ChIP-Seq_ESCs_Human0.99697084
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98838909
112* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98256827
113TP53_22573176_ChIP-Seq_HFKS_Human0.97514009
114CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.97499948
115HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97455572
116* CRX_20693478_ChIP-Seq_RETINA_Mouse0.97016924
117KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96723544
118KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96599391
119SOX2_16153702_ChIP-ChIP_HESCs_Human0.96528307
120TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96400058
121* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96125723
122* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90730395
123TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89884423
124CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88522080
125TFEB_21752829_ChIP-Seq_HELA_Human0.88441140
126FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87522364
127E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87515513
128* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86416283
129SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85823355
130* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84007840
131NOTCH1_21737748_ChIP-Seq_TLL_Human0.83947034
132SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81673582
133SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.80570339
134* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80173219
135EZH2_22144423_ChIP-Seq_EOC_Human0.80018572
136CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.77037383
137FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75767237
138KLF4_18555785_ChIP-Seq_MESCs_Mouse0.74624082
139TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.72935204
140NANOG_16153702_ChIP-ChIP_HESCs_Human0.72892523
141FUS_26573619_Chip-Seq_HEK293_Human0.72575580
142HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.71864024
143TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.71035315
144* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.69515731
145POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.69423345
146MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.69133158
147SOX17_20123909_ChIP-Seq_XEN_Mouse0.68805158
148EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.68366574

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.37781976
2MP0003123_paternal_imprinting3.14135710
3MP0003646_muscle_fatigue2.91836414
4MP0003693_abnormal_embryo_hatching2.89384852
5MP0004957_abnormal_blastocyst_morpholog2.76593303
6MP0003122_maternal_imprinting2.59450814
7MP0010094_abnormal_chromosome_stability2.53071348
8MP0001529_abnormal_vocalization2.43200027
9MP0003880_abnormal_central_pattern2.42070094
10MP0001984_abnormal_olfaction2.40000589
11MP0003121_genomic_imprinting2.28302330
12* MP0003077_abnormal_cell_cycle2.21236603
13MP0003111_abnormal_nucleus_morphology2.16645159
14MP0008058_abnormal_DNA_repair2.14316030
15* MP0008932_abnormal_embryonic_tissue2.07186845
16MP0003787_abnormal_imprinting2.02420323
17MP0002938_white_spotting1.83150263
18MP0004859_abnormal_synaptic_plasticity1.82904480
19MP0008057_abnormal_DNA_replication1.76905228
20MP0006276_abnormal_autonomic_nervous1.73265027
21MP0005171_absent_coat_pigmentation1.72482526
22MP0003718_maternal_effect1.70819896
23MP0006292_abnormal_olfactory_placode1.68106128
24MP0004084_abnormal_cardiac_muscle1.65157871
25MP0004145_abnormal_muscle_electrophysio1.63896095
26MP0002837_dystrophic_cardiac_calcinosis1.62794185
27MP0003186_abnormal_redox_activity1.61735208
28MP0005253_abnormal_eye_physiology1.58961532
29MP0003786_premature_aging1.54251135
30MP0008007_abnormal_cellular_replicative1.51655075
31MP0002736_abnormal_nociception_after1.51525236
32MP0001905_abnormal_dopamine_level1.50726714
33MP0000749_muscle_degeneration1.46001395
34MP0001968_abnormal_touch/_nociception1.45238692
35MP0003136_yellow_coat_color1.40743017
36MP0002233_abnormal_nose_morphology1.39599820
37MP0002653_abnormal_ependyma_morphology1.38655005
38MP0003011_delayed_dark_adaptation1.37922393
39MP0003315_abnormal_perineum_morphology1.37338183
40MP0003941_abnormal_skin_development1.36479372
41MP0001293_anophthalmia1.33108223
42MP0005551_abnormal_eye_electrophysiolog1.32603500
43MP0002234_abnormal_pharynx_morphology1.32417956
44MP0001188_hyperpigmentation1.32083979
45MP0004036_abnormal_muscle_relaxation1.30207886
46MP0003937_abnormal_limbs/digits/tail_de1.29110072
47MP0002090_abnormal_vision1.28387238
48MP0004233_abnormal_muscle_weight1.27698194
49MP0003635_abnormal_synaptic_transmissio1.27398249
50MP0001730_embryonic_growth_arrest1.26095683
51MP0005248_abnormal_Harderian_gland1.21051802
52MP0002735_abnormal_chemical_nociception1.20847932
53MP0002210_abnormal_sex_determination1.19505555
54MP0009745_abnormal_behavioral_response1.17762463
55MP0000751_myopathy1.17531246
56MP0002751_abnormal_autonomic_nervous1.17469705
57MP0009046_muscle_twitch1.17362038
58MP0002734_abnormal_mechanical_nocicepti1.17328728
59MP0010030_abnormal_orbit_morphology1.16891051
60MP0003950_abnormal_plasma_membrane1.12570541
61MP0006036_abnormal_mitochondrial_physio1.12295981
62MP0006035_abnormal_mitochondrial_morpho1.12190443
63MP0002063_abnormal_learning/memory/cond1.11775234
64MP0002163_abnormal_gland_morphology1.11651680
65MP0005503_abnormal_tendon_morphology1.10418747
66MP0004133_heterotaxia1.07901151
67MP0005395_other_phenotype1.06207023
68MP0004215_abnormal_myocardial_fiber1.05776888
69MP0000778_abnormal_nervous_system1.05052894
70MP0003567_abnormal_fetal_cardiomyocyte1.04594837
71MP0003890_abnormal_embryonic-extraembry1.03406043
72MP0002160_abnormal_reproductive_system1.02910275
73MP0002572_abnormal_emotion/affect_behav1.02621244
74MP0000350_abnormal_cell_proliferation1.01853074
75MP0005187_abnormal_penis_morphology1.00845774
76MP0002064_seizures0.99733855
77MP0003119_abnormal_digestive_system0.98648074
78* MP0001697_abnormal_embryo_size0.98168966
79MP0003755_abnormal_palate_morphology0.97865747
80MP0002272_abnormal_nervous_system0.95322295
81MP0004142_abnormal_muscle_tone0.95230998
82MP0000647_abnormal_sebaceous_gland0.94809526
83MP0000631_abnormal_neuroendocrine_gland0.94199776
84MP0010386_abnormal_urinary_bladder0.93546455
85MP0001486_abnormal_startle_reflex0.92897594
86MP0002282_abnormal_trachea_morphology0.92888624
87MP0001929_abnormal_gametogenesis0.92688348
88MP0006054_spinal_hemorrhage0.91963742
89MP0001145_abnormal_male_reproductive0.90945437
90MP0003942_abnormal_urinary_system0.90765057
91MP0002638_abnormal_pupillary_reflex0.89900170
92MP0000653_abnormal_sex_gland0.88847456
93MP0009697_abnormal_copulation0.88478968
94MP0003806_abnormal_nucleotide_metabolis0.87514305
95MP0002184_abnormal_innervation0.86243714
96MP0000049_abnormal_middle_ear0.86187139
97MP0005408_hypopigmentation0.85809705
98MP0000678_abnormal_parathyroid_gland0.85684664
99MP0009250_abnormal_appendicular_skeleto0.85466578
100MP0002106_abnormal_muscle_physiology0.84678908
101MP0002127_abnormal_cardiovascular_syste0.84558741
102MP0002822_catalepsy0.84511734
103MP0004484_altered_response_of0.83772690
104MP0003137_abnormal_impulse_conducting0.82331723
105MP0001177_atelectasis0.82012709
106MP0005084_abnormal_gallbladder_morpholo0.81766642
107MP0001970_abnormal_pain_threshold0.81232410
108MP0005391_vision/eye_phenotype0.81172749
109MP0005394_taste/olfaction_phenotype0.81035951
110MP0005499_abnormal_olfactory_system0.81035951
111MP0008789_abnormal_olfactory_epithelium0.80248205
112* MP0002080_prenatal_lethality0.79942767
113MP0000358_abnormal_cell_content/0.79823629
114MP0000759_abnormal_skeletal_muscle0.79222666
115MP0001324_abnormal_eye_pigmentation0.78408414
116MP0000372_irregular_coat_pigmentation0.78388116
117MP0004270_analgesia0.78347685
118MP0000750_abnormal_muscle_regeneration0.77868407
119MP0006072_abnormal_retinal_apoptosis0.77441068
120MP0005646_abnormal_pituitary_gland0.77167583
121MP0003879_abnormal_hair_cell0.76534046
122MP0001299_abnormal_eye_distance/0.76457149
123MP0005620_abnormal_muscle_contractility0.75939443
124MP0005389_reproductive_system_phenotype0.75247773
125MP0000681_abnormal_thyroid_gland0.75014775
126MP0001286_abnormal_eye_development0.74983045
127MP0005369_muscle_phenotype0.74664234
128MP0009379_abnormal_foot_pigmentation0.74574706
129MP0002102_abnormal_ear_morphology0.74109440
130MP0002067_abnormal_sensory_capabilities0.73680303
131MP0004924_abnormal_behavior0.73605588
132MP0005386_behavior/neurological_phenoty0.73605588
133MP0003698_abnormal_male_reproductive0.73602603
134MP0002085_abnormal_embryonic_tissue0.73336262
135MP0002752_abnormal_somatic_nervous0.73120169
136MP0004811_abnormal_neuron_physiology0.72847432
137MP0003221_abnormal_cardiomyocyte_apopto0.72793149
138MP0002269_muscular_atrophy0.72437143
139MP0001727_abnormal_embryo_implantation0.71915378
140MP0001119_abnormal_female_reproductive0.71065916

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.71533652
2Abnormal mitochondria in muscle tissue (HP:0008316)4.29872066
3Abnormality of glycolysis (HP:0004366)3.96667483
4Increased serum pyruvate (HP:0003542)3.96667483
5Mitochondrial inheritance (HP:0001427)3.87478571
6Progressive macrocephaly (HP:0004481)3.73127747
7Increased CSF lactate (HP:0002490)3.53631256
8Hepatocellular necrosis (HP:0001404)3.44384105
9Acute encephalopathy (HP:0006846)3.43256809
10Cerebral hypomyelination (HP:0006808)3.23924147
11Birth length less than 3rd percentile (HP:0003561)3.05564007
12Exercise intolerance (HP:0003546)2.77874720
13Neuroendocrine neoplasm (HP:0100634)2.77363144
14Hepatic necrosis (HP:0002605)2.75873063
15Degeneration of anterior horn cells (HP:0002398)2.74540269
16Abnormality of the anterior horn cell (HP:0006802)2.74540269
173-Methylglutaconic aciduria (HP:0003535)2.71300940
18Abnormality of the labia minora (HP:0012880)2.65728374
19Metaphyseal dysplasia (HP:0100255)2.64088259
20Increased serum lactate (HP:0002151)2.63788413
21Abnormality of alanine metabolism (HP:0010916)2.59062778
22Hyperalaninemia (HP:0003348)2.59062778
23Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.59062778
24Breast hypoplasia (HP:0003187)2.57734453
25Irregular epiphyses (HP:0010582)2.55707764
26Type 2 muscle fiber atrophy (HP:0003554)2.55415425
27Pancreatic fibrosis (HP:0100732)2.52639415
28Pheochromocytoma (HP:0002666)2.51740591
29Microvesicular hepatic steatosis (HP:0001414)2.47500421
30Methylmalonic acidemia (HP:0002912)2.44897237
31Carpal bone hypoplasia (HP:0001498)2.43078821
32Abnormal hair whorl (HP:0010721)2.42351359
33Shoulder girdle muscle weakness (HP:0003547)2.40984203
34Respiratory failure (HP:0002878)2.39928806
35Renal Fanconi syndrome (HP:0001994)2.38861177
36Lactic acidosis (HP:0003128)2.38815034
37Decreased activity of mitochondrial respiratory chain (HP:0008972)2.37330244
38Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.37330244
39Molar tooth sign on MRI (HP:0002419)2.36259822
40Abnormality of midbrain morphology (HP:0002418)2.36259822
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.33775077
42Muscle fiber atrophy (HP:0100295)2.32990552
43Agnosia (HP:0010524)2.31636984
44Colon cancer (HP:0003003)2.30384662
45Delusions (HP:0000746)2.29769806
46Emotional lability (HP:0000712)2.28269287
47Optic disc pallor (HP:0000543)2.27618722
48Atrophy/Degeneration involving motor neurons (HP:0007373)2.26613973
49Unsteady gait (HP:0002317)2.25699517
50Patellar aplasia (HP:0006443)2.24258385
51Abnormality of the ileum (HP:0001549)2.23404501
52Bifid tongue (HP:0010297)2.23124787
53Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.20346862
54Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17046461
55Aplasia/Hypoplasia of the tongue (HP:0010295)2.16131200
56Aplasia/Hypoplasia of the patella (HP:0006498)2.15043051
57Abnormality of chromosome stability (HP:0003220)2.13988691
58Chromosomal breakage induced by crosslinking agents (HP:0003221)2.11739248
59Poor suck (HP:0002033)2.11194382
60Hyperglycinemia (HP:0002154)2.11131264
61Aplastic anemia (HP:0001915)2.08899339
62Vaginal atresia (HP:0000148)2.08310404
63Postnatal microcephaly (HP:0005484)2.07246524
64Leukodystrophy (HP:0002415)2.04034621
65Intestinal atresia (HP:0011100)2.03726348
66Chromsome breakage (HP:0040012)2.03348326
67Atonic seizures (HP:0010819)2.03056877
68Delayed gross motor development (HP:0002194)2.02259946
6911 pairs of ribs (HP:0000878)2.00664271
70Increased hepatocellular lipid droplets (HP:0006565)2.00336177
71Methylmalonic aciduria (HP:0012120)1.99893372
72Neuroblastic tumors (HP:0004376)1.99852358
73Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.99852358
74Neuroblastoma (HP:0003006)1.99852358
75Primitive neuroectodermal tumor (HP:0030065)1.99852358
76Nephronophthisis (HP:0000090)1.97694924
77Rough bone trabeculation (HP:0100670)1.97259448
78Abnormal lung lobation (HP:0002101)1.97206717
79Myokymia (HP:0002411)1.96878035
80Oligodactyly (hands) (HP:0001180)1.95776546
81Supernumerary spleens (HP:0009799)1.95190266
82Medial flaring of the eyebrow (HP:0010747)1.94782305
83Rimmed vacuoles (HP:0003805)1.89777813
84CNS hypomyelination (HP:0003429)1.89317672
85Postaxial hand polydactyly (HP:0001162)1.88664338
86Aplasia/Hypoplasia of the fovea (HP:0008060)1.88571916
87Hypoplasia of the fovea (HP:0007750)1.88571916
88Median cleft lip (HP:0000161)1.88267857
89Tongue fasciculations (HP:0001308)1.86542231
90Hypoplasia of the capital femoral epiphysis (HP:0003090)1.86498919
91Exercise-induced muscle cramps (HP:0003710)1.85035197
92Abnormality of the fovea (HP:0000493)1.84351704
93Hypoplastic pelvis (HP:0008839)1.83702122
94Small intestinal stenosis (HP:0012848)1.83638605
95Duodenal stenosis (HP:0100867)1.83638605
96True hermaphroditism (HP:0010459)1.83058319
97Type I transferrin isoform profile (HP:0003642)1.81892523
98Volvulus (HP:0002580)1.80224889
99Focal motor seizures (HP:0011153)1.78250992
100Gait imbalance (HP:0002141)1.77771449
101Neoplasm of the adrenal gland (HP:0100631)1.77253935
102Aplasia/Hypoplasia of the tibia (HP:0005772)1.77236585
103Abnormality of the duodenum (HP:0002246)1.76989740
104Septo-optic dysplasia (HP:0100842)1.76937914
105Congenital primary aphakia (HP:0007707)1.76707480
106Postaxial foot polydactyly (HP:0001830)1.76146652
107Pancreatic cysts (HP:0001737)1.75532981
108Abnormality of the preputium (HP:0100587)1.75026312
109Fetal akinesia sequence (HP:0001989)1.75025933
110Abnormal protein glycosylation (HP:0012346)1.74151911
111Abnormal glycosylation (HP:0012345)1.74151911
112Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74151911
113Abnormal protein N-linked glycosylation (HP:0012347)1.74151911
114Absent epiphyses (HP:0010577)1.74078736
115Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.74078736
116Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.73937299
117Short middle phalanx of the 5th finger (HP:0004220)1.72913343
118Lipid accumulation in hepatocytes (HP:0006561)1.72715705
119Neoplasm of the peripheral nervous system (HP:0100007)1.70498093
120Muscle fibrillation (HP:0010546)1.70360295
121Preaxial hand polydactyly (HP:0001177)1.69973656
122Nephrogenic diabetes insipidus (HP:0009806)1.69959090
123Broad foot (HP:0001769)1.69384391
124Increased intramyocellular lipid droplets (HP:0012240)1.69189713
125Abnormality of the musculature of the pelvis (HP:0001469)1.68962862
126Abnormality of the hip-girdle musculature (HP:0001445)1.68962862
127Short tibia (HP:0005736)1.68483139
128Progressive external ophthalmoplegia (HP:0000590)1.68168087
129Pelvic girdle muscle weakness (HP:0003749)1.68053721
130Optic nerve hypoplasia (HP:0000609)1.67774649
131Premature graying of hair (HP:0002216)1.67583836
132X-linked dominant inheritance (HP:0001423)1.67478411
133Sloping forehead (HP:0000340)1.66884516
134Renal cortical cysts (HP:0000803)1.66877697
135Abnormality of serum amino acid levels (HP:0003112)1.66796052
136Nemaline bodies (HP:0003798)1.66413767
137Exertional dyspnea (HP:0002875)1.65788812
138Ependymoma (HP:0002888)1.64991237
139Facial cleft (HP:0002006)1.64352524
140Cerebral edema (HP:0002181)1.64341637
141Hypothermia (HP:0002045)1.63605534
142Progressive inability to walk (HP:0002505)1.62358371
143Aplasia/hypoplasia of the uterus (HP:0008684)1.62357615
144Abnormality of aspartate family amino acid metabolism (HP:0010899)1.61254338
145Sclerocornea (HP:0000647)1.60938914
146Genital tract atresia (HP:0001827)1.59245192
147Ragged-red muscle fibers (HP:0003200)1.58942949
148CNS demyelination (HP:0007305)1.58826832
149Embryonal renal neoplasm (HP:0011794)1.57813688
150Limb dystonia (HP:0002451)1.57731909
151Absent septum pellucidum (HP:0001331)1.57697532
152Meckel diverticulum (HP:0002245)1.56093530

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.21313946
2TRIM283.52049912
3EIF2AK13.38053132
4MST42.70563980
5STK162.54223477
6TSSK62.47733426
7MAP3K122.38704669
8WNK32.37388907
9NME12.36539305
10MAP2K72.29320226
11NEK12.28829914
12WEE12.23297742
13LIMK12.22202564
14CDC72.16926134
15MAP4K22.11841362
16NUAK12.04744298
17STK38L1.93118777
18BMPR1B1.92466345
19SIK31.84599243
20VRK21.83425241
21SRPK11.82431612
22CDK191.82421742
23TESK11.77817751
24TNIK1.75624691
25PLK41.74772780
26CCNB11.74282264
27ACVR1B1.71866019
28PLK31.68144204
29VRK11.67542054
30CASK1.65282960
31PLK21.62113443
32TESK21.60122815
33CSNK1G11.59629192
34BRAF1.56460563
35PRKD31.54783800
36CSNK1G31.54160578
37MINK11.46658117
38CSNK1G21.45986403
39ARAF1.44312441
40EIF2AK31.42617746
41FRK1.39430850
42ERBB31.38900495
43MYLK1.38359868
44PLK11.38241359
45BMPR21.33946959
46NTRK31.31811939
47CSNK1A1L1.31380390
48BRSK11.26475421
49KSR11.25774324
50OBSCN1.25307071
51BRSK21.23725561
52MAP3K41.23633648
53TTK1.23147673
54DYRK21.21537898
55MKNK11.21158686
56AURKA1.19348564
57TLK11.16074400
58NME21.15565079
59MAPK131.15337951
60PNCK1.15104919
61LATS21.12403248
62CDK81.08295509
63PDK31.07635439
64PDK41.07635439
65MKNK21.04400326
66BCR1.02530680
67MOS1.01657743
68DAPK10.97135854
69PINK10.96574479
70CHEK20.88208802
71MAP3K90.86229041
72STK240.82938557
73CDK180.79322956
74CDK140.78353970
75GRK50.78010702
76LMTK20.75768503
77STK30.74956664
78TAF10.74651288
79ZAK0.74491206
80PHKG20.73701262
81PHKG10.73701262
82GRK10.71099532
83CDK11A0.69091618
84LATS10.67144589
85CDK150.67075584
86PAK30.65908252
87GRK70.65726335
88MAP2K40.64754606
89PRKCE0.60607537
90AURKB0.60592768
91AKT30.59222381
92PBK0.57569200
93CDK70.57395386
94PRPF4B0.57085236
95OXSR10.56071791
96DAPK30.54420897
97MARK10.53815701
98ATR0.53784294
99ADRBK20.52995162
100MAP3K80.51851673
101PRKCG0.49380961
102BCKDK0.49029511
103KSR20.48606072
104EPHA40.47391931
105ADRBK10.47258375
106ERBB40.47236197
107CSNK2A10.45910052
108NTRK20.45055903
109ATM0.44524841
110PAK60.43686114
111STK390.43607565
112PAK10.43431379
113RAF10.43017056
114YES10.42421876
115DYRK1A0.40530834
116EIF2AK20.39894852
117INSRR0.39806649
118MAP3K60.39682689
119FER0.39180400
120PASK0.38776730
121CAMKK20.38235485
122NTRK10.38078277
123TGFBR10.37811633
124PAK40.37282366
125CAMK2A0.36778902
126PDK20.36586054
127FGFR10.35906231
128UHMK10.35701860
129MUSK0.35600021
130CHEK10.35314489
131FLT30.35161961
132ILK0.34128077
133TIE10.33989285
134CSNK2A20.31790706

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.46427397
2RNA polymerase_Homo sapiens_hsa030203.46474784
3Oxidative phosphorylation_Homo sapiens_hsa001903.19859984
4Parkinsons disease_Homo sapiens_hsa050122.99331871
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97859377
6DNA replication_Homo sapiens_hsa030302.79335936
7Mismatch repair_Homo sapiens_hsa034302.60668273
8RNA transport_Homo sapiens_hsa030132.41562103
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.40671182
10Spliceosome_Homo sapiens_hsa030402.38917250
11Huntingtons disease_Homo sapiens_hsa050162.38799259
12Ribosome_Homo sapiens_hsa030102.27294387
13Basal transcription factors_Homo sapiens_hsa030222.20557863
14Homologous recombination_Homo sapiens_hsa034402.14456889
15Propanoate metabolism_Homo sapiens_hsa006402.11753733
16Nucleotide excision repair_Homo sapiens_hsa034202.08193458
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.03306704
18Fatty acid elongation_Homo sapiens_hsa000621.99377932
19Base excision repair_Homo sapiens_hsa034101.98348751
20Cell cycle_Homo sapiens_hsa041101.91038121
21Alzheimers disease_Homo sapiens_hsa050101.90690603
22Pyrimidine metabolism_Homo sapiens_hsa002401.83243953
23Protein export_Homo sapiens_hsa030601.74319834
24Steroid biosynthesis_Homo sapiens_hsa001001.73377575
25Synaptic vesicle cycle_Homo sapiens_hsa047211.67117154
26RNA degradation_Homo sapiens_hsa030181.66863252
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61639849
28Oocyte meiosis_Homo sapiens_hsa041141.61559384
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59933603
30Cardiac muscle contraction_Homo sapiens_hsa042601.57576096
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49492861
32Collecting duct acid secretion_Homo sapiens_hsa049661.48608326
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47228458
34Fanconi anemia pathway_Homo sapiens_hsa034601.39111238
35mRNA surveillance pathway_Homo sapiens_hsa030151.39039983
36Purine metabolism_Homo sapiens_hsa002301.36817099
37Folate biosynthesis_Homo sapiens_hsa007901.36136304
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32941375
39Vibrio cholerae infection_Homo sapiens_hsa051101.28647086
40Nicotine addiction_Homo sapiens_hsa050331.25178651
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21790996
42Butanoate metabolism_Homo sapiens_hsa006501.17333019
43Epstein-Barr virus infection_Homo sapiens_hsa051691.05741942
44Glutathione metabolism_Homo sapiens_hsa004801.04280629
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03894879
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02774929
47Non-homologous end-joining_Homo sapiens_hsa034500.95310766
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85444328
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82850875
50Peroxisome_Homo sapiens_hsa041460.81309380
51Sulfur metabolism_Homo sapiens_hsa009200.80878225
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77559798
53Vitamin B6 metabolism_Homo sapiens_hsa007500.75306912
54SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73365565
55Caffeine metabolism_Homo sapiens_hsa002320.73185675
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72327548
57Selenocompound metabolism_Homo sapiens_hsa004500.72120201
58Dopaminergic synapse_Homo sapiens_hsa047280.71432905
59Nitrogen metabolism_Homo sapiens_hsa009100.70059954
60p53 signaling pathway_Homo sapiens_hsa041150.69071859
61Arginine and proline metabolism_Homo sapiens_hsa003300.67568834
62Amphetamine addiction_Homo sapiens_hsa050310.65568343
63Fructose and mannose metabolism_Homo sapiens_hsa000510.63458955
64Long-term potentiation_Homo sapiens_hsa047200.63435881
65Serotonergic synapse_Homo sapiens_hsa047260.62860550
66Fatty acid metabolism_Homo sapiens_hsa012120.61334067
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60176232
68GABAergic synapse_Homo sapiens_hsa047270.60047282
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59761249
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58788243
71Morphine addiction_Homo sapiens_hsa050320.58648097
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58197826
73One carbon pool by folate_Homo sapiens_hsa006700.57144932
74Tryptophan metabolism_Homo sapiens_hsa003800.54549548
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53167455
76Type I diabetes mellitus_Homo sapiens_hsa049400.52734543
77beta-Alanine metabolism_Homo sapiens_hsa004100.52219424
78Circadian entrainment_Homo sapiens_hsa047130.51507300
79Regulation of autophagy_Homo sapiens_hsa041400.50765276
80Rheumatoid arthritis_Homo sapiens_hsa053230.48105181
81Thyroid cancer_Homo sapiens_hsa052160.47396461
82Olfactory transduction_Homo sapiens_hsa047400.47172552
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46769163
84Phagosome_Homo sapiens_hsa041450.46067447
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45976875
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45615488
87Gap junction_Homo sapiens_hsa045400.44417283
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44302484
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43594087
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43494181
91Shigellosis_Homo sapiens_hsa051310.43158625
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43142832
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41679020
94Dilated cardiomyopathy_Homo sapiens_hsa054140.41640163
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41228857
96Hedgehog signaling pathway_Homo sapiens_hsa043400.41223774
97Taste transduction_Homo sapiens_hsa047420.40809481
98Long-term depression_Homo sapiens_hsa047300.40606363
99HTLV-I infection_Homo sapiens_hsa051660.40182550
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39461138
101Fatty acid degradation_Homo sapiens_hsa000710.37092786
102N-Glycan biosynthesis_Homo sapiens_hsa005100.36719634
103Carbon metabolism_Homo sapiens_hsa012000.36309179
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35210060
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35179883
106Cocaine addiction_Homo sapiens_hsa050300.34955566
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34627042
108Alcoholism_Homo sapiens_hsa050340.34516313
109Oxytocin signaling pathway_Homo sapiens_hsa049210.34320512
110Chemical carcinogenesis_Homo sapiens_hsa052040.33813335
111Graft-versus-host disease_Homo sapiens_hsa053320.33395438
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33131555
113Calcium signaling pathway_Homo sapiens_hsa040200.32841209
114Primary bile acid biosynthesis_Homo sapiens_hsa001200.32822679
115Cholinergic synapse_Homo sapiens_hsa047250.31633112
116Hippo signaling pathway_Homo sapiens_hsa043900.31331057
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30643048
118Pyruvate metabolism_Homo sapiens_hsa006200.30617006
119Biosynthesis of amino acids_Homo sapiens_hsa012300.30426815
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29674130
121Herpes simplex infection_Homo sapiens_hsa051680.28509269
122Circadian rhythm_Homo sapiens_hsa047100.28492802
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27720220
124Legionellosis_Homo sapiens_hsa051340.27348791
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.27295919
126HIF-1 signaling pathway_Homo sapiens_hsa040660.26569007
127Basal cell carcinoma_Homo sapiens_hsa052170.26214598
128Glutamatergic synapse_Homo sapiens_hsa047240.25673101
129Insulin secretion_Homo sapiens_hsa049110.24266062
130GnRH signaling pathway_Homo sapiens_hsa049120.23288159
131Viral carcinogenesis_Homo sapiens_hsa052030.22963408
132Metabolic pathways_Homo sapiens_hsa011000.21773223
133TGF-beta signaling pathway_Homo sapiens_hsa043500.21502915
134Wnt signaling pathway_Homo sapiens_hsa043100.19783785
135Phototransduction_Homo sapiens_hsa047440.18650163
136Galactose metabolism_Homo sapiens_hsa000520.17558330
137Melanoma_Homo sapiens_hsa052180.17432707

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