ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	potassium ion export (GO:0071435)	8.35470896
2	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	8.13499880
3	membrane repolarization during action potential (GO:0086011)	7.20656492
4	interkinetic nuclear migration (GO:0022027)	6.50998783
5	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	5.73005093
6	cellular ketone body metabolic process (GO:0046950)	5.25620643
7	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	5.21264749
8	positive regulation of prostaglandin secretion (GO:0032308)	5.19808228
9	positive regulation of potassium ion transmembrane transport (GO:1901381)	5.19741284
10	membrane repolarization (GO:0086009)	5.13635092
11	interleukin-1-mediated signaling pathway (GO:0070498)	5.05083976
12	positive regulation of heat generation (GO:0031652)	4.81366421
13	spermatid nucleus differentiation (GO:0007289)	4.71092193
14	ketone body metabolic process (GO:1902224)	4.70940688
15	acrosome assembly (GO:0001675)	4.54826735
16	regulation of heat generation (GO:0031650)	4.51279253
17	regulation of fever generation (GO:0031620)	4.39191188
18	regulation of interleukin-6 biosynthetic process (GO:0045408)	4.37500683
19	magnesium ion transport (GO:0015693)	4.34746814
20	regulation of prostaglandin secretion (GO:0032306)	4.32368884
21	parental behavior (GO:0060746)	4.31631385
22	positive regulation of icosanoid secretion (GO:0032305)	4.30302787
23	DNA deamination (GO:0045006)	4.22415104
24	indolalkylamine metabolic process (GO:0006586)	4.20515592
25	positive regulation of fatty acid transport (GO:2000193)	4.14719297
26	maternal behavior (GO:0042711)	4.12961946
27	regulation of interleukin-12 biosynthetic process (GO:0045075)	4.04759777
28	regulation of membrane repolarization (GO:0060306)	3.98249124
29	tyrosine phosphorylation of STAT protein (GO:0007260)	3.77041599
30	positive regulation of steroid hormone secretion (GO:2000833)	3.76642800
31	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	3.69394169
32	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.65038603
33	regulation of mitotic spindle checkpoint (GO:1903504)	3.65038603
34	preassembly of GPI anchor in ER membrane (GO:0016254)	3.62153850
35	activated T cell proliferation (GO:0050798)	3.48531934
36	regulation of icosanoid secretion (GO:0032303)	3.40598338
37	Leydig cell differentiation (GO:0033327)	3.30623943
38	negative regulation of smooth muscle cell differentiation (GO:0051151)	3.28066330
39	heme transport (GO:0015886)	3.27498753
40	water-soluble vitamin biosynthetic process (GO:0042364)	3.21155254
41	platelet dense granule organization (GO:0060155)	3.20401343
42	ubiquinone biosynthetic process (GO:0006744)	3.16147602
43	regulation of heart rate by cardiac conduction (GO:0086091)	3.16085690
44	neuron remodeling (GO:0016322)	3.14778235
45	regulation of gamma-delta T cell differentiation (GO:0045586)	3.09044882
46	piRNA metabolic process (GO:0034587)	3.08588096
47	indole-containing compound metabolic process (GO:0042430)	3.05286177
48	endocrine hormone secretion (GO:0060986)	3.04390170
49	neutrophil activation involved in immune response (GO:0002283)	2.99867505
50	ventricular cardiac muscle cell action potential (GO:0086005)	2.99714556
51	forebrain morphogenesis (GO:0048853)	2.96608435
52	osteoclast differentiation (GO:0030316)	2.93728744
53	protein deneddylation (GO:0000338)	2.91680543
54	regulation of pigment cell differentiation (GO:0050932)	2.90206521
55	positive regulation of potassium ion transport (GO:0043268)	2.88361421
56	negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)	2.85450455
57	aggressive behavior (GO:0002118)	2.84107963
58	cellular response to interleukin-15 (GO:0071350)	2.82283558
59	nephron tubule morphogenesis (GO:0072078)	2.81747139
60	nephron epithelium morphogenesis (GO:0072088)	2.81747139
61	GPI anchor biosynthetic process (GO:0006506)	2.81065970
62	ubiquinone metabolic process (GO:0006743)	2.79704646
63	cAMP catabolic process (GO:0006198)	2.79424730
64	regulation of action potential (GO:0098900)	2.75689188
65	positive regulation of organic acid transport (GO:0032892)	2.74287024
66	peptide catabolic process (GO:0043171)	2.72354086
67	tryptophan catabolic process (GO:0006569)	2.71833749
68	indole-containing compound catabolic process (GO:0042436)	2.71833749
69	indolalkylamine catabolic process (GO:0046218)	2.71833749
70	synaptic vesicle exocytosis (GO:0016079)	2.71833032
71	protein-cofactor linkage (GO:0018065)	2.70503351
72	cardiac conduction (GO:0061337)	2.69285265
73	iron-sulfur cluster assembly (GO:0016226)	2.69208709
74	metallo-sulfur cluster assembly (GO:0031163)	2.69208709
75	neuronal stem cell maintenance (GO:0097150)	2.68966970
76	regulation of immunoglobulin secretion (GO:0051023)	2.68925865
77	keratinocyte proliferation (GO:0043616)	2.68311721
78	nucleus localization (GO:0051647)	2.66234827
79	branched-chain amino acid catabolic process (GO:0009083)	2.63171585
80	sperm motility (GO:0030317)	2.62427691
81	response to interleukin-15 (GO:0070672)	2.61081758
82	GPI anchor metabolic process (GO:0006505)	2.59644242
83	phospholipid homeostasis (GO:0055091)	2.58758390
84	regulation of potassium ion transmembrane transporter activity (GO:1901016)	2.55895012
85	positive regulation of lipid transport (GO:0032370)	2.54906967
86	response to lipoprotein particle (GO:0055094)	2.54786508
87	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.52126140
88	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.52126140
89	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.50815842
90	quinone biosynthetic process (GO:1901663)	2.48745777
91	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.47480368
92	tryptophan metabolic process (GO:0006568)	2.46671435
93	neutrophil activation (GO:0042119)	2.45623268
94	kynurenine metabolic process (GO:0070189)	2.44208740
95	central nervous system myelination (GO:0022010)	2.44002257
96	axon ensheathment in central nervous system (GO:0032291)	2.44002257
97	regulation of energy homeostasis (GO:2000505)	2.42566728
98	positive regulation of interleukin-12 production (GO:0032735)	2.41508888
99	peptidyl-threonine dephosphorylation (GO:0035970)	2.41428152
100	protein neddylation (GO:0045116)	2.40545078

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	4.55085207
2	ZNF274_21170338_ChIP-Seq_K562_Hela	2.88053042
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.75629144
4	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.65124507
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.37406429
6	VDR_22108803_ChIP-Seq_LS180_Human	2.36601398
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.31620067
8	FUS_26573619_Chip-Seq_HEK293_Human	2.24693302
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.20864132
10	EWS_26573619_Chip-Seq_HEK293_Human	2.18806439
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.16742126
12	GATA1_22025678_ChIP-Seq_K562_Human	2.11326295
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.09073665
14	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.08348363
15	GBX2_23144817_ChIP-Seq_PC3_Human	2.07061222
16	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.03875775
17	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.99816176
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.98226946
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.95131548
20	MYC_18940864_ChIP-ChIP_HL60_Human	1.84086744
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.82528390
22	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.81450400
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.76814239
24	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.74590125
25	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.74153308
26	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.70468713
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.69333803
28	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.66488983
29	P300_19829295_ChIP-Seq_ESCs_Human	1.66450881
30	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.65185387
31	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.62620474
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.62614254
33	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.55847495
34	TAF15_26573619_Chip-Seq_HEK293_Human	1.55531469
35	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.54754539
36	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.54599915
37	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.52890689
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.49230908
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.49230908
40	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.46268853
41	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.41111251
42	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.38813898
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.35176455
44	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.35176455
45	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.32840168
46	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.32415716
47	IGF1R_20145208_ChIP-Seq_DFB_Human	1.32189076
48	RUNX_20019798_ChIP-Seq_JUKART_Human	1.31457227
49	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.30332068
50	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.29225501
51	HOXB7_26014856_ChIP-Seq_BT474_Human	1.29221271
52	CDX2_22108803_ChIP-Seq_LS180_Human	1.28583614
53	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.28561553
54	VDR_23849224_ChIP-Seq_CD4+_Human	1.28557314
55	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.27002302
56	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.26739955
57	NCOR_22424771_ChIP-Seq_293T_Human	1.25004183
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.24100530
59	SOX2_19829295_ChIP-Seq_ESCs_Human	1.24100530
60	TCF4_23295773_ChIP-Seq_U87_Human	1.22142137
61	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.21540546
62	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.21431953
63	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.21360165
64	TP53_22573176_ChIP-Seq_HFKS_Human	1.21290887
65	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.20978720
66	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.20326881
67	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.20304818
68	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.19355870
69	SMAD4_21799915_ChIP-Seq_A2780_Human	1.18209503
70	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.16631969
71	AR_20517297_ChIP-Seq_VCAP_Human	1.12494554
72	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.11503250
73	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.10583978
74	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.10061228
75	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.09694073
76	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.09536603
77	P53_22387025_ChIP-Seq_ESCs_Mouse	1.09315177
78	BCAT_22108803_ChIP-Seq_LS180_Human	1.09231405
79	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.08750349
80	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.08211143
81	STAT3_23295773_ChIP-Seq_U87_Human	1.08078105
82	RUNX2_22187159_ChIP-Seq_PCA_Human	1.06850651
83	GATA3_26560356_Chip-Seq_TH2_Human	1.06343726
84	EZH2_22144423_ChIP-Seq_EOC_Human	1.04999787
85	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.04228482
86	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.04212748
87	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.03056131
88	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01373892
89	P300_18555785_Chip-Seq_ESCs_Mouse	1.01019165
90	AR_25329375_ChIP-Seq_VCAP_Human	1.00989778
91	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.00496927
92	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99697073
93	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.99684699
94	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99684699
95	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.98880207
96	MYB_26560356_Chip-Seq_TH2_Human	0.98585064
97	IRF1_19129219_ChIP-ChIP_H3396_Human	0.98175797
98	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.97641939
99	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.97618561
100	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.96614339

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003878_abnormal_ear_physiology	6.99509538
2	MP0005377_hearing/vestibular/ear_phenot	6.99509538
3	MP0002163_abnormal_gland_morphology	3.22311408
4	MP0009379_abnormal_foot_pigmentation	3.09521116
5	MP0001485_abnormal_pinna_reflex	3.02485194
6	MP0003195_calcinosis	2.89873085
7	MP0005379_endocrine/exocrine_gland_phen	2.85881773
8	MP0001188_hyperpigmentation	2.68485927
9	MP0006292_abnormal_olfactory_placode	2.53699446
10	MP0009384_cardiac_valve_regurgitation	2.52716335
11	MP0010368_abnormal_lymphatic_system	2.50285216
12	MP0005084_abnormal_gallbladder_morpholo	2.46936874
13	MP0005174_abnormal_tail_pigmentation	2.37613380
14	MP0003136_yellow_coat_color	2.30253041
15	MP0001919_abnormal_reproductive_system	2.16397049
16	MP0002009_preneoplasia	2.12890469
17	MP0005671_abnormal_response_to	2.03394570
18	MP0000015_abnormal_ear_pigmentation	1.81833190
19	MP0002928_abnormal_bile_duct	1.78049786
20	MP0004215_abnormal_myocardial_fiber	1.73113231
21	MP0002822_catalepsy	1.72464976
22	MP0005389_reproductive_system_phenotype	1.60415423
23	MP0002160_abnormal_reproductive_system	1.59423625
24	MP0002095_abnormal_skin_pigmentation	1.58998521
25	MP0000685_abnormal_immune_system	1.54424644
26	MP0003137_abnormal_impulse_conducting	1.46625891
27	MP0002148_abnormal_hypersensitivity_rea	1.45119337
28	MP0006072_abnormal_retinal_apoptosis	1.44953420
29	MP0009764_decreased_sensitivity_to	1.41804648
30	MP0001800_abnormal_humoral_immune	1.41305449
31	MP0009046_muscle_twitch	1.39262748
32	MP0005187_abnormal_penis_morphology	1.38417345
33	MP0005636_abnormal_mineral_homeostasis	1.37324345
34	MP0002933_joint_inflammation	1.32402114
35	MP0008875_abnormal_xenobiotic_pharmacok	1.31068271
36	MP0003724_increased_susceptibility_to	1.24696188
37	MP0003011_delayed_dark_adaptation	1.23149872
38	MP0001790_abnormal_immune_system	1.22076692
39	MP0005387_immune_system_phenotype	1.22076692
40	MP0001879_abnormal_lymphatic_vessel	1.20917011
41	MP0001486_abnormal_startle_reflex	1.17725674
42	MP0002102_abnormal_ear_morphology	1.17058390
43	MP0004142_abnormal_muscle_tone	1.15183158
44	MP0001835_abnormal_antigen_presentation	1.14301787
45	MP0001873_stomach_inflammation	1.13363479
46	MP0005253_abnormal_eye_physiology	1.13161143
47	MP0002405_respiratory_system_inflammati	1.11082850
48	MP0003183_abnormal_peptide_metabolism	1.09538102
49	MP0001765_abnormal_ion_homeostasis	1.05000782
50	MP0002723_abnormal_immune_serum	1.04207448
51	MP0005551_abnormal_eye_electrophysiolog	1.00858700
52	MP0004885_abnormal_endolymph	0.98009346
53	MP0004145_abnormal_muscle_electrophysio	0.95343231
54	MP0004742_abnormal_vestibular_system	0.93654823
55	MP0005646_abnormal_pituitary_gland	0.93476162
56	MP0000689_abnormal_spleen_morphology	0.92502084
57	MP0008877_abnormal_DNA_methylation	0.81505658
58	MP0002067_abnormal_sensory_capabilities	0.80997074
59	MP0002229_neurodegeneration	0.80421707
60	MP0005000_abnormal_immune_tolerance	0.79991262
61	MP0001663_abnormal_digestive_system	0.79671079
62	MP0003436_decreased_susceptibility_to	0.79450015
63	MP0002272_abnormal_nervous_system	0.78728358
64	MP0009745_abnormal_behavioral_response	0.78504582
65	MP0001853_heart_inflammation	0.75708274
66	MP0002452_abnormal_antigen_presenting	0.75321929
67	MP0004782_abnormal_surfactant_physiolog	0.75316168
68	MP0002064_seizures	0.74263628
69	MP0001968_abnormal_touch/_nociception	0.73859387
70	MP0003828_pulmonary_edema	0.73241458
71	MP0002398_abnormal_bone_marrow	0.72726992
72	MP0000631_abnormal_neuroendocrine_gland	0.70209938
73	MP0001293_anophthalmia	0.69949574
74	MP0002735_abnormal_chemical_nociception	0.68047876
75	MP0004043_abnormal_pH_regulation	0.67786074
76	MP0000569_abnormal_digit_pigmentation	0.67564629
77	MP0001963_abnormal_hearing_physiology	0.66489587
78	MP0002420_abnormal_adaptive_immunity	0.65677044
79	MP0001845_abnormal_inflammatory_respons	0.64896317
80	MP0008058_abnormal_DNA_repair	0.64322762
81	MP0000716_abnormal_immune_system	0.63905410
82	MP0008569_lethality_at_weaning	0.63856379
83	MP0000427_abnormal_hair_cycle	0.63778654
84	MP0000026_abnormal_inner_ear	0.63687450
85	MP0000538_abnormal_urinary_bladder	0.63137045
86	MP0000372_irregular_coat_pigmentation	0.63063920
87	MP0002653_abnormal_ependyma_morphology	0.62286272
88	MP0005409_darkened_coat_color	0.62006490
89	MP0005584_abnormal_enzyme/coenzyme_acti	0.61942507
90	MP0006054_spinal_hemorrhage	0.61888234
91	MP0002837_dystrophic_cardiac_calcinosis	0.61002050
92	MP0001819_abnormal_immune_cell	0.60747704
93	MP0004147_increased_porphyrin_level	0.60026492
94	MP0005075_abnormal_melanosome_morpholog	0.59301126
95	MP0009785_altered_susceptibility_to	0.56906646
96	MP0001533_abnormal_skeleton_physiology	0.56685654
97	MP0008469_abnormal_protein_level	0.54883825
98	MP0002722_abnormal_immune_system	0.54714190
99	MP0010155_abnormal_intestine_physiology	0.52812431
100	MP0001881_abnormal_mammary_gland	0.52683426

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Ventricular fibrillation (HP:0001663)	5.53856873
2	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	4.36447922
3	Degeneration of the lateral corticospinal tracts (HP:0002314)	4.36447922
4	Prolonged QT interval (HP:0001657)	3.50444050
5	Hypochromic microcytic anemia (HP:0004840)	3.46341577
6	Birth length less than 3rd percentile (HP:0003561)	3.39585372
7	Syncope (HP:0001279)	3.36594417
8	Agammaglobulinemia (HP:0004432)	3.23476068
9	Atonic seizures (HP:0010819)	3.17942576
10	Chronic mucocutaneous candidiasis (HP:0002728)	3.13517234
11	Recurrent cutaneous fungal infections (HP:0011370)	3.13517234
12	Abnormality of the corticospinal tract (HP:0002492)	3.06556491
13	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.98483644
14	Ketoacidosis (HP:0001993)	2.96213299
15	Abnormality of T cell number (HP:0011839)	2.94484683
16	Premature loss of primary teeth (HP:0006323)	2.91304102
17	Abolished electroretinogram (ERG) (HP:0000550)	2.90191618
18	Type II lissencephaly (HP:0007260)	2.82258591
19	Febrile seizures (HP:0002373)	2.80549553
20	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.80546798
21	Chronic sinusitis (HP:0011109)	2.79938269
22	Termporal pattern (HP:0011008)	2.67580588
23	Insidious onset (HP:0003587)	2.67580588
24	Increased density of long bones (HP:0006392)	2.64510739
25	Urinary bladder sphincter dysfunction (HP:0002839)	2.59389025
26	Ketosis (HP:0001946)	2.56106167
27	Decreased central vision (HP:0007663)	2.50836291
28	Severe combined immunodeficiency (HP:0004430)	2.50752550
29	Colon cancer (HP:0003003)	2.46366926
30	Rhinitis (HP:0012384)	2.43997907
31	T lymphocytopenia (HP:0005403)	2.42621548
32	Decreased circulating renin level (HP:0003351)	2.40895779
33	IgG deficiency (HP:0004315)	2.40788264
34	Enlarged epiphyses (HP:0010580)	2.39682377
35	Recurrent bronchitis (HP:0002837)	2.38380776
36	Genetic anticipation (HP:0003743)	2.38197101
37	Chronic hepatic failure (HP:0100626)	2.37484933
38	Choroideremia (HP:0001139)	2.34305126
39	Thyroiditis (HP:0100646)	2.34240032
40	Cerebellar dysplasia (HP:0007033)	2.33476040
41	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.32126545
42	Absent/shortened dynein arms (HP:0200106)	2.32126545
43	Hypochromic anemia (HP:0001931)	2.30084906
44	Spontaneous abortion (HP:0005268)	2.29943936
45	Exertional dyspnea (HP:0002875)	2.29734825
46	Abnormal ciliary motility (HP:0012262)	2.28471259
47	Panhypogammaglobulinemia (HP:0003139)	2.25358646
48	Broad-based gait (HP:0002136)	2.25041860
49	Hypoplasia of the thymus (HP:0000778)	2.24402365
50	Abnormality of T cells (HP:0002843)	2.23227595
51	Hyperventilation (HP:0002883)	2.23185361
52	Congenital, generalized hypertrichosis (HP:0004540)	2.22656709
53	Progressive cerebellar ataxia (HP:0002073)	2.21204212
54	Abnormal respiratory epithelium morphology (HP:0012253)	2.21006426
55	Abnormal respiratory motile cilium morphology (HP:0005938)	2.21006426
56	Hyperkalemia (HP:0002153)	2.18428899
57	Abnormality of T cell physiology (HP:0011840)	2.17990693
58	Lipid accumulation in hepatocytes (HP:0006561)	2.17613104
59	Acute hepatic failure (HP:0006554)	2.15502202
60	Cerebral hemorrhage (HP:0001342)	2.15142137
61	Chronic diarrhea (HP:0002028)	2.11219106
62	Hypoproteinemia (HP:0003075)	2.07133455
63	Abnormal EKG (HP:0003115)	2.05277106
64	Autoimmune thrombocytopenia (HP:0001973)	2.04710861
65	Congenital stationary night blindness (HP:0007642)	2.04407630
66	Epileptic encephalopathy (HP:0200134)	2.04053032
67	Inability to walk (HP:0002540)	2.00336451
68	Facial hemangioma (HP:0000329)	1.98590283
69	Macular degeneration (HP:0000608)	1.97001321
70	Abnormal albumin level (HP:0012116)	1.96730185
71	Hypoalbuminemia (HP:0003073)	1.96730185
72	Stillbirth (HP:0003826)	1.96268407
73	Attenuation of retinal blood vessels (HP:0007843)	1.94671607
74	Encephalitis (HP:0002383)	1.93235417
75	Pigmentary retinal degeneration (HP:0001146)	1.92518791
76	Metabolic alkalosis (HP:0200114)	1.91485907
77	Morphological abnormality of the pyramidal tract (HP:0002062)	1.90933602
78	3-Methylglutaconic aciduria (HP:0003535)	1.90756374
79	True hermaphroditism (HP:0010459)	1.88537551
80	Chronic otitis media (HP:0000389)	1.88155812
81	Dyskinesia (HP:0100660)	1.86028829
82	Mesangial abnormality (HP:0001966)	1.84972924
83	Hypokalemic alkalosis (HP:0001949)	1.83038108
84	Gastrointestinal infarctions (HP:0005244)	1.82528855
85	Recurrent fungal infections (HP:0002841)	1.81929518
86	Abnormality of chloride homeostasis (HP:0011422)	1.80464980
87	Prominent metopic ridge (HP:0005487)	1.80399315
88	Heterochromia iridis (HP:0001100)	1.78858105
89	Amaurosis fugax (HP:0100576)	1.77884035
90	Pancreatic fibrosis (HP:0100732)	1.77475740
91	Abnormality of eosinophils (HP:0001879)	1.76498693
92	Submucous cleft hard palate (HP:0000176)	1.75324902
93	Clonus (HP:0002169)	1.75166509
94	Stenosis of the external auditory canal (HP:0000402)	1.74883895
95	Impaired vibration sensation in the lower limbs (HP:0002166)	1.72917569
96	Combined immunodeficiency (HP:0005387)	1.72533024
97	Pancreatic cysts (HP:0001737)	1.71734568
98	Recurrent skin infections (HP:0001581)	1.71350141
99	Increased IgM level (HP:0003496)	1.70423182
100	Hyperalaninemia (HP:0003348)	1.70402252

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TIE1	6.81548901
2	TXK	4.29155317
3	MAP3K13	3.79070386
4	ZAK	3.16614737
5	ADRBK2	2.98664039
6	STK38L	2.87240574
7	TEC	2.69424855
8	STK24	2.60437692
9	BCKDK	2.57661386
10	TSSK6	2.13164449
11	EPHB1	1.79376246
12	BMPR1B	1.77538162
13	JAK3	1.72817367
14	FRK	1.68610429
15	STK3	1.58115363
16	CDC42BPA	1.56781232
17	GRK1	1.52143462
18	CAMKK2	1.43096410
19	TLK1	1.42346034
20	BCR	1.38328885
21	MAPK15	1.37419153
22	TESK2	1.36402668
23	CDK8	1.34319679
24	NEK1	1.33932203
25	PNCK	1.31922031
26	WEE1	1.31449389
27	MAP4K1	1.30762659
28	NUAK1	1.30736620
29	TAOK3	1.16346618
30	KIT	1.12668881
31	MAP3K4	1.12361779
32	MELK	1.12191046
33	VRK1	1.08222849
34	ITK	1.05960954
35	CCNB1	1.03576790
36	GRK7	0.99658385
37	MAP2K2	0.91951967
38	CASK	0.88076174
39	WNK3	0.87276922
40	MST4	0.85523262
41	ADRBK1	0.84940004
42	PDK2	0.83655162
43	NTRK2	0.83516828
44	BTK	0.82302468
45	TYRO3	0.81319204
46	IGF1R	0.81116127
47	MAP3K14	0.80198904
48	IKBKB	0.77772008
49	IKBKE	0.72532993
50	PRKCQ	0.72374269
51	PLK4	0.71765765
52	SYK	0.67670511
53	LCK	0.66639263
54	CSF1R	0.65670284
55	MAP3K5	0.63542162
56	NEK9	0.61262830
57	TGFBR1	0.60087707
58	NEK2	0.59636017
59	MAP2K7	0.59454697
60	CSNK1G2	0.58942648
61	EPHA4	0.58539651
62	LYN	0.56526093
63	RIPK4	0.55588997
64	MAP3K7	0.52210210
65	PLK3	0.52159161
66	CSNK1G3	0.51085180
67	ALK	0.48980036
68	PRKCA	0.48144237
69	CSNK1A1L	0.46476389
70	PASK	0.45867843
71	TRIM28	0.43755727
72	INSRR	0.43112931
73	ABL1	0.42462966
74	CDK9	0.41729739
75	RPS6KB2	0.40816750
76	MAPK7	0.40090509
77	MAP2K6	0.39297648
78	EIF2AK2	0.37122656
79	STK4	0.36904245
80	ACVR1B	0.36872111
81	STK16	0.36608366
82	GRK6	0.35666641
83	PAK3	0.35316754
84	CSNK1G1	0.34313026
85	ATR	0.33993251
86	CHUK	0.33551434
87	FES	0.33457901
88	PINK1	0.32546454
89	PTK2B	0.32109385
90	STK10	0.31747391
91	OBSCN	0.30393292
92	PRKCH	0.29190694
93	KDR	0.29189465
94	PRKACA	0.29061201
95	HCK	0.27745857
96	CDK19	0.27693349
97	PRKCG	0.26580228
98	RPS6KA5	0.25962920
99	WNK4	0.24572171
100	TNIK	0.23821273

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	5.52874992
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.37389791
3	Tryptophan metabolism_Homo sapiens_hsa00380	2.98865808
4	Butanoate metabolism_Homo sapiens_hsa00650	2.96990838
5	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.69633482
6	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.59369737
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.19793084
8	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.15888850
9	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.14925176
10	NF-kappa B signaling pathway_Homo sapiens_hsa04064	2.02310588
11	Caffeine metabolism_Homo sapiens_hsa00232	2.01591124
12	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.00914080
13	Rheumatoid arthritis_Homo sapiens_hsa05323	1.96545056
14	Primary immunodeficiency_Homo sapiens_hsa05340	1.95618408
15	Asthma_Homo sapiens_hsa05310	1.86596484
16	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.66048364
17	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.62901753
18	Type I diabetes mellitus_Homo sapiens_hsa04940	1.62560949
19	Graft-versus-host disease_Homo sapiens_hsa05332	1.59691779
20	Peroxisome_Homo sapiens_hsa04146	1.55449206
21	Allograft rejection_Homo sapiens_hsa05330	1.51270268
22	RNA polymerase_Homo sapiens_hsa03020	1.44194244
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.43503185
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.37988206
25	Phototransduction_Homo sapiens_hsa04744	1.36448342
26	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.33714800
27	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.30547892
28	Phenylalanine metabolism_Homo sapiens_hsa00360	1.21429247
29	Basal transcription factors_Homo sapiens_hsa03022	1.20482840
30	Homologous recombination_Homo sapiens_hsa03440	1.18647061
31	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.16970795
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.13760879
33	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.10593650
34	ABC transporters_Homo sapiens_hsa02010	1.10549806
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.07555065
36	Collecting duct acid secretion_Homo sapiens_hsa04966	1.06656236
37	Morphine addiction_Homo sapiens_hsa05032	1.05178250
38	One carbon pool by folate_Homo sapiens_hsa00670	1.02310049
39	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.00367883
40	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.00059660
41	Propanoate metabolism_Homo sapiens_hsa00640	0.96798848
42	Selenocompound metabolism_Homo sapiens_hsa00450	0.94383566
43	Antigen processing and presentation_Homo sapiens_hsa04612	0.93169895
44	Nicotine addiction_Homo sapiens_hsa05033	0.91966200
45	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.91652517
46	RNA degradation_Homo sapiens_hsa03018	0.87281564
47	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.85069443
48	Taste transduction_Homo sapiens_hsa04742	0.82755162
49	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.82424744
50	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.81280634
51	beta-Alanine metabolism_Homo sapiens_hsa00410	0.80017747
52	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.76740662
53	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.76157998
54	Mismatch repair_Homo sapiens_hsa03430	0.75473225
55	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.70924058
56	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.69864815
57	Purine metabolism_Homo sapiens_hsa00230	0.68309184
58	Circadian entrainment_Homo sapiens_hsa04713	0.68155330
59	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.64663083
60	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.63763000
61	Proteasome_Homo sapiens_hsa03050	0.63334808
62	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.63197152
63	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.62271842
64	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.60034929
65	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.59381429
66	Salivary secretion_Homo sapiens_hsa04970	0.57590265
67	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.57444969
68	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.56162453
69	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.54870669
70	mRNA surveillance pathway_Homo sapiens_hsa03015	0.53139996
71	Serotonergic synapse_Homo sapiens_hsa04726	0.52030104
72	Steroid biosynthesis_Homo sapiens_hsa00100	0.51928717
73	Nucleotide excision repair_Homo sapiens_hsa03420	0.50044286
74	Pyrimidine metabolism_Homo sapiens_hsa00240	0.48000205
75	Glutamatergic synapse_Homo sapiens_hsa04724	0.46731530
76	Circadian rhythm_Homo sapiens_hsa04710	0.46212022
77	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.45838792
78	Calcium signaling pathway_Homo sapiens_hsa04020	0.43745518
79	Retinol metabolism_Homo sapiens_hsa00830	0.42171782
80	Oxidative phosphorylation_Homo sapiens_hsa00190	0.41894114
81	African trypanosomiasis_Homo sapiens_hsa05143	0.41891612
82	Tyrosine metabolism_Homo sapiens_hsa00350	0.41696481
83	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.40595436
84	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.39919349
85	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.39688873
86	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.37633380
87	Fatty acid metabolism_Homo sapiens_hsa01212	0.36125207
88	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.33581596
89	RNA transport_Homo sapiens_hsa03013	0.31036653
90	Insulin secretion_Homo sapiens_hsa04911	0.29873707
91	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.29691173
92	Ether lipid metabolism_Homo sapiens_hsa00565	0.28613936
93	GABAergic synapse_Homo sapiens_hsa04727	0.27507968
94	Measles_Homo sapiens_hsa05162	0.26289287
95	Leishmaniasis_Homo sapiens_hsa05140	0.25796612
96	Gastric acid secretion_Homo sapiens_hsa04971	0.25540864
97	Pancreatic secretion_Homo sapiens_hsa04972	0.25255930
98	Olfactory transduction_Homo sapiens_hsa04740	0.24990268
99	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.24264180
100	Metabolic pathways_Homo sapiens_hsa01100	0.24222500

COPS8P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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