COPZ1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the cytoplasmic coatamer protein complex, which is involved in autophagy and intracellular protein trafficking. The coatomer protein complex is comprised of seven subunits and functions as the coat protein of coat protein complex (COP)I-vesicles. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.22166043
2establishment of integrated proviral latency (GO:0075713)4.82193603
3SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.52541915
4cotranslational protein targeting to membrane (GO:0006613)4.50127310
5* COPI coating of Golgi vesicle (GO:0048205)4.48460041
6* Golgi transport vesicle coating (GO:0048200)4.48460041
7protein targeting to ER (GO:0045047)4.42041189
8ATP synthesis coupled proton transport (GO:0015986)4.39582148
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.39582148
10establishment of protein localization to endoplasmic reticulum (GO:0072599)4.32663803
11viral transcription (GO:0019083)4.30162293
12protein maturation by protein folding (GO:0022417)4.26503367
13protein localization to endoplasmic reticulum (GO:0070972)4.25435886
14establishment of viral latency (GO:0019043)4.17316442
15translational termination (GO:0006415)4.16364448
16nucleobase biosynthetic process (GO:0046112)4.15307399
17purine nucleobase biosynthetic process (GO:0009113)4.03238653
18folic acid-containing compound biosynthetic process (GO:0009396)3.91161944
19ribosomal small subunit biogenesis (GO:0042274)3.88597721
20oxidative phosphorylation (GO:0006119)3.87867801
21formation of translation preinitiation complex (GO:0001731)3.81051981
22translational elongation (GO:0006414)3.78946426
23regulation of mitochondrial translation (GO:0070129)3.76844435
24ribosomal small subunit assembly (GO:0000028)3.75058282
25ribosomal large subunit biogenesis (GO:0042273)3.74580684
26viral life cycle (GO:0019058)3.68416251
27DNA strand elongation involved in DNA replication (GO:0006271)3.66753246
28translational initiation (GO:0006413)3.64495553
29regulation of translational fidelity (GO:0006450)3.63898280
30respiratory electron transport chain (GO:0022904)3.61528294
31nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.59668764
32DNA strand elongation (GO:0022616)3.54692640
33telomere maintenance via semi-conservative replication (GO:0032201)3.54678444
34translation (GO:0006412)3.52959548
35electron transport chain (GO:0022900)3.52891615
36establishment of protein localization to mitochondrial membrane (GO:0090151)3.51028566
37mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.49762715
38signal peptide processing (GO:0006465)3.47748634
39tRNA aminoacylation for protein translation (GO:0006418)3.45137988
40tricarboxylic acid cycle (GO:0006099)3.41796067
41protein deneddylation (GO:0000338)3.40089559
42cellular protein complex disassembly (GO:0043624)3.37066758
43amino acid activation (GO:0043038)3.33181642
44tRNA aminoacylation (GO:0043039)3.33181642
45maturation of SSU-rRNA (GO:0030490)3.30179418
46cullin deneddylation (GO:0010388)3.28313828
47maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.24257832
48protein targeting to membrane (GO:0006612)3.19154046
49L-serine metabolic process (GO:0006563)3.19120111
50DNA deamination (GO:0045006)3.18664538
51pteridine-containing compound biosynthetic process (GO:0042559)3.17473678
52protein targeting to mitochondrion (GO:0006626)3.16898512
53proteasome assembly (GO:0043248)3.16656423
54IMP biosynthetic process (GO:0006188)3.15948512
55protein complex disassembly (GO:0043241)3.09292957
56telomere maintenance via recombination (GO:0000722)3.08826138
57negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.08780640
58nuclear envelope reassembly (GO:0031468)3.07242683
59mitotic nuclear envelope reassembly (GO:0007084)3.07242683
60antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.06927146
61macromolecular complex disassembly (GO:0032984)3.06163920
62protein retention in ER lumen (GO:0006621)3.05490487
63tetrahydrofolate metabolic process (GO:0046653)3.02689595
64pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.02552039
65positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.02047539
66DNA replication checkpoint (GO:0000076)3.01577116
67protein localization to mitochondrion (GO:0070585)2.99022437
68regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.98381562
69establishment of protein localization to mitochondrion (GO:0072655)2.97892168
70deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.97703243
71antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.95654325
72chaperone-mediated protein transport (GO:0072321)2.94678233
73ribonucleoprotein complex biogenesis (GO:0022613)2.94135692
74de novo protein folding (GO:0006458)2.91905498
75de novo posttranslational protein folding (GO:0051084)2.91782483
76anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.91307588
77DNA replication initiation (GO:0006270)2.90217085
78folic acid metabolic process (GO:0046655)2.89703830
79guanosine-containing compound biosynthetic process (GO:1901070)2.89024367
80protein neddylation (GO:0045116)2.88853995
81pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.87737035
82mitochondrial fusion (GO:0008053)2.86543053
83aerobic respiration (GO:0009060)2.85844528
84* retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.84344231
85UMP metabolic process (GO:0046049)2.84233106
86pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.84233106
87UMP biosynthetic process (GO:0006222)2.84233106
88pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.84233106
89regulation of cellular amino acid metabolic process (GO:0006521)2.82258017
90regulation of ubiquitin-protein transferase activity (GO:0051438)2.81120832
91DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.80633283
92telomere maintenance via telomere lengthening (GO:0010833)2.79526111
93mitotic recombination (GO:0006312)2.77662478
94protoporphyrinogen IX biosynthetic process (GO:0006782)2.77401398
95signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.76753665
96intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.76753665
97antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.76578780
98signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.76302118
99signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.76302118
100signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.76302118
101cellular component biogenesis (GO:0044085)2.76072252
102negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.72337550
103negative regulation of ligase activity (GO:0051352)2.72337550
104regulation of ligase activity (GO:0051340)2.70940397
105NADH metabolic process (GO:0006734)2.70381009
106protein localization to kinetochore (GO:0034501)2.70033526
107protoporphyrinogen IX metabolic process (GO:0046501)2.68392853
108signal transduction involved in DNA integrity checkpoint (GO:0072401)2.67303923
109signal transduction involved in DNA damage checkpoint (GO:0072422)2.67303923
110glycine metabolic process (GO:0006544)2.66830316
111protein complex biogenesis (GO:0070271)2.65855694
112folic acid-containing compound metabolic process (GO:0006760)2.65373942
113ribonucleoprotein complex disassembly (GO:0032988)2.65173539
114IMP metabolic process (GO:0046040)2.65015293
115proline biosynthetic process (GO:0006561)2.64819513
116L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.64674983
117signal transduction involved in cell cycle checkpoint (GO:0072395)2.64423434
118pentose-phosphate shunt (GO:0006098)2.63417171
119serine family amino acid biosynthetic process (GO:0009070)2.63208026
120viral protein processing (GO:0019082)2.63122179
121regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.62885134
122ATP biosynthetic process (GO:0006754)2.62732849
123establishment of protein localization to membrane (GO:0090150)2.62436026
124positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.61703139
125GMP metabolic process (GO:0046037)2.61005490
126positive regulation of mitochondrial fission (GO:0090141)2.59578675
127mitochondrial transport (GO:0006839)2.59463177
128virion assembly (GO:0019068)2.58947942
129nucleoside salvage (GO:0043174)2.57940660
130purine nucleoside triphosphate biosynthetic process (GO:0009145)2.57696420
131amino acid salvage (GO:0043102)2.57339717
132L-methionine salvage (GO:0071267)2.57339717
133L-methionine biosynthetic process (GO:0071265)2.57339717
134nuclear-transcribed mRNA catabolic process (GO:0000956)2.55755764
135misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.54638263
136pteridine-containing compound metabolic process (GO:0042558)2.54006154
1372-deoxyribonucleotide biosynthetic process (GO:0009265)2.53503773
138deoxyribose phosphate biosynthetic process (GO:0046385)2.53503773
139nucleobase-containing small molecule interconversion (GO:0015949)2.52684636
140positive regulation of ligase activity (GO:0051351)2.52511021
141DNA unwinding involved in DNA replication (GO:0006268)2.51255183
142COPII vesicle coating (GO:0048208)2.50875348
143aldehyde catabolic process (GO:0046185)2.50568325
144nucleotide-excision repair, DNA gap filling (GO:0006297)2.49911795
145sulfur amino acid biosynthetic process (GO:0000097)2.46265274
146G1/S transition of mitotic cell cycle (GO:0000082)2.45262117
147cell cycle G1/S phase transition (GO:0044843)2.45262117
148mitotic nuclear envelope disassembly (GO:0007077)2.42427899
149one-carbon metabolic process (GO:0006730)2.41936380
150deoxyribonucleotide biosynthetic process (GO:0009263)2.40893171
151methionine biosynthetic process (GO:0009086)2.40363709
152ribosome biogenesis (GO:0042254)2.40095459
153erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.39816436
154L-phenylalanine metabolic process (GO:0006558)2.39816436
155purine-containing compound salvage (GO:0043101)2.39531123
156pseudouridine synthesis (GO:0001522)2.36505213
157purine nucleobase metabolic process (GO:0006144)2.34904197
158L-phenylalanine catabolic process (GO:0006559)2.34586419
159erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.34586419
160CENP-A containing nucleosome assembly (GO:0034080)2.33551150
161GDP-mannose metabolic process (GO:0019673)2.33089310
162transcription-coupled nucleotide-excision repair (GO:0006283)2.33082515
163mitotic metaphase plate congression (GO:0007080)2.31285747
164viral mRNA export from host cell nucleus (GO:0046784)2.31167272
165rRNA modification (GO:0000154)2.30841090
166peptide catabolic process (GO:0043171)2.30717473
167heme biosynthetic process (GO:0006783)2.29406092
168valine metabolic process (GO:0006573)2.28496811

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.77508989
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.87847337
3* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.39338158
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.30015433
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.21719380
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.02262615
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.97369184
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.95392373
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.77815872
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.60319714
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.57577767
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.55703912
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.53820707
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.30636910
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.27614016
16* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21213461
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.20545830
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.19478006
19ZNF263_19887448_ChIP-Seq_K562_Human2.13169904
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.09669186
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08340097
22* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06934840
23VDR_23849224_ChIP-Seq_CD4+_Human2.05981770
24CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.05803974
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.04525216
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99598156
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.97546326
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.96699927
29GABP_19822575_ChIP-Seq_HepG2_Human1.94520803
30DCP1A_22483619_ChIP-Seq_HELA_Human1.93711130
31FOXM1_23109430_ChIP-Seq_U2OS_Human1.92257210
32FOXP3_21729870_ChIP-Seq_TREG_Human1.87800340
33XRN2_22483619_ChIP-Seq_HELA_Human1.87029508
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79793847
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.79591674
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.77589066
37* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.74140740
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71900167
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71138191
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.70823355
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69107681
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.67866210
43AR_21909140_ChIP-Seq_LNCAP_Human1.63459574
44* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62149389
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.61869452
46IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.60998428
47PPARA_22158963_ChIP-Seq_LIVER_Mouse1.59869053
48RXR_22158963_ChIP-Seq_LIVER_Mouse1.56700275
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.54619696
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.50162067
51* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49576429
52ELK1_19687146_ChIP-ChIP_HELA_Human1.49118350
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48238216
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48108504
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45301076
56* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.45099998
57IRF8_21731497_ChIP-ChIP_J774_Mouse1.44577011
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42854618
59CIITA_25753668_ChIP-Seq_RAJI_Human1.41306124
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41284214
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.40767532
62* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40395720
63ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.38168442
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.37755931
65TFEB_21752829_ChIP-Seq_HELA_Human1.33746458
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33715713
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31943194
68KDM5A_27292631_Chip-Seq_BREAST_Human1.30424688
69TTF2_22483619_ChIP-Seq_HELA_Human1.30233724
70HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30058877
71NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27252892
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26860231
73SOX17_20123909_ChIP-Seq_XEN_Mouse1.25614888
74MYC_22102868_ChIP-Seq_BL_Human1.25456880
75GATA1_22025678_ChIP-Seq_K562_Human1.23533347
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23444574
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21647857
78* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21049873
79SPI1_23547873_ChIP-Seq_NB4_Human1.20553493
80ELK1_22589737_ChIP-Seq_MCF10A_Human1.20469469
81SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20080938
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19091192
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17937696
84HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17778288
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.17749077
86NANOG_21062744_ChIP-ChIP_HESCs_Human1.15351502
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12912903
88* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.11762154
89SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11515693
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11218179
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07620688
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07274049
93CLOCK_20551151_ChIP-Seq_293T_Human1.07029979
94SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06548407
95CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06055690
96* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05812437
97NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05004477
98TBX5_21415370_ChIP-Seq_HL-1_Mouse1.04340320
99* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03524250
100MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02723202
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01956288
102ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01202837
103ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.00419346
104TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.99593405
105ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99280368
106* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98741858
107KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98653718
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98572911
109STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98560321
110TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.97043611
111CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96620696
112SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96447760
113POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93678093
114GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92800168
115CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90960884
116STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90815818
117HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89507414
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89445141
119KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89214886
120TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87496602
121PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84592405
122STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.84477103
123NOTCH1_21737748_ChIP-Seq_TLL_Human0.84038334
124LXR_22158963_ChIP-Seq_LIVER_Mouse0.84031245
125KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.83309452
126RBPJ_22232070_ChIP-Seq_NCS_Mouse0.82860746

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.64855921
2MP0003806_abnormal_nucleotide_metabolis3.58115505
3MP0002139_abnormal_hepatobiliary_system3.41754316
4MP0005360_urolithiasis2.99261749
5MP0005365_abnormal_bile_salt2.92087320
6MP0010234_abnormal_vibrissa_follicle2.59854459
7MP0005085_abnormal_gallbladder_physiolo2.57481706
8MP0010030_abnormal_orbit_morphology2.56335853
9MP0009379_abnormal_foot_pigmentation2.53815349
10MP0004957_abnormal_blastocyst_morpholog2.42399287
11MP0003186_abnormal_redox_activity2.40858811
12MP0010094_abnormal_chromosome_stability2.40697911
13MP0003111_abnormal_nucleus_morphology2.29774746
14MP0003077_abnormal_cell_cycle2.26926198
15MP0003656_abnormal_erythrocyte_physiolo2.20174350
16MP0006054_spinal_hemorrhage2.10519767
17MP0001529_abnormal_vocalization2.09704038
18MP0008058_abnormal_DNA_repair2.08077479
19MP0008007_abnormal_cellular_replicative1.92712450
20MP0001835_abnormal_antigen_presentation1.86607333
21MP0005248_abnormal_Harderian_gland1.86361882
22MP0009840_abnormal_foam_cell1.82059000
23MP0006035_abnormal_mitochondrial_morpho1.79646274
24MP0008057_abnormal_DNA_replication1.79110729
25MP0001764_abnormal_homeostasis1.78870479
26MP0008875_abnormal_xenobiotic_pharmacok1.76539037
27MP0002938_white_spotting1.75291740
28MP0002396_abnormal_hematopoietic_system1.71021092
29MP0008438_abnormal_cutaneous_collagen1.67885654
30MP0001666_abnormal_nutrient_absorption1.66892199
31MP0005083_abnormal_biliary_tract1.64129245
32MP0001727_abnormal_embryo_implantation1.62966867
33MP0009697_abnormal_copulation1.61463874
34MP0003123_paternal_imprinting1.60949560
35MP0000490_abnormal_crypts_of1.60459394
36MP0008789_abnormal_olfactory_epithelium1.59901223
37MP0010329_abnormal_lipoprotein_level1.58026219
38MP0001346_abnormal_lacrimal_gland1.48528780
39MP0003436_decreased_susceptibility_to1.46728249
40MP0005379_endocrine/exocrine_gland_phen1.45600338
41MP0003195_calcinosis1.43828487
42MP0004264_abnormal_extraembryonic_tissu1.41541785
43MP0009333_abnormal_splenocyte_physiolog1.39469521
44MP0009785_altered_susceptibility_to1.38157721
45MP0003191_abnormal_cellular_cholesterol1.33899134
46MP0004147_increased_porphyrin_level1.33379097
47MP0002132_abnormal_respiratory_system1.32788015
48MP0002163_abnormal_gland_morphology1.32745243
49MP0008932_abnormal_embryonic_tissue1.32710362
50MP0005397_hematopoietic_system_phenotyp1.31918954
51MP0001545_abnormal_hematopoietic_system1.31918954
52MP0005332_abnormal_amino_acid1.31554829
53MP0005220_abnormal_exocrine_pancreas1.31081729
54MP0002877_abnormal_melanocyte_morpholog1.30407224
55MP0005501_abnormal_skin_physiology1.29142414
56MP0000462_abnormal_digestive_system1.27009312
57MP0005319_abnormal_enzyme/_coenzyme1.26118365
58MP0005408_hypopigmentation1.25879006
59MP0006072_abnormal_retinal_apoptosis1.25873560
60MP0005464_abnormal_platelet_physiology1.25258692
61MP0004272_abnormal_basement_membrane1.22878358
62MP0004782_abnormal_surfactant_physiolog1.22490629
63MP0003315_abnormal_perineum_morphology1.22159758
64MP0005499_abnormal_olfactory_system1.20397212
65MP0005394_taste/olfaction_phenotype1.20397212
66MP0000609_abnormal_liver_physiology1.19920201
67MP0004233_abnormal_muscle_weight1.18981282
68MP0000598_abnormal_liver_morphology1.18239620
69MP0005058_abnormal_lysosome_morphology1.17169048
70MP0001697_abnormal_embryo_size1.16506621
71MP0009643_abnormal_urine_homeostasis1.15334392
72MP0002653_abnormal_ependyma_morphology1.15086857
73MP0002697_abnormal_eye_size1.13824289
74MP0002019_abnormal_tumor_incidence1.12938208
75MP0006036_abnormal_mitochondrial_physio1.12664168
76MP0001853_heart_inflammation1.10945807
77MP0000566_synostosis1.10358689
78MP0005025_abnormal_response_to1.09434574
79MP0002138_abnormal_hepatobiliary_system1.09361660
80MP0003566_abnormal_cell_adhesion1.08804844
81MP0001730_embryonic_growth_arrest1.08802065
82MP0002148_abnormal_hypersensitivity_rea1.08730149
83MP0003763_abnormal_thymus_physiology1.08562368
84MP0005671_abnormal_response_to1.07952103
85MP0003011_delayed_dark_adaptation1.07656108
86MP0001661_extended_life_span1.07171802
87MP0003252_abnormal_bile_duct1.06542855
88MP0009780_abnormal_chondrocyte_physiolo1.06497728
89MP0002084_abnormal_developmental_patter1.06392414
90MP0001672_abnormal_embryogenesis/_devel1.06277673
91MP0005380_embryogenesis_phenotype1.06277673
92MP0000537_abnormal_urethra_morphology1.06136852
93MP0002085_abnormal_embryonic_tissue1.06073662
94MP0002419_abnormal_innate_immunity1.05306980
95MP0010352_gastrointestinal_tract_polyps1.05227576
96MP0008469_abnormal_protein_level1.04652040
97MP0002398_abnormal_bone_marrow1.04028601
98MP0000858_altered_metastatic_potential1.03813008
99MP0003942_abnormal_urinary_system1.03176524
100MP0008995_early_reproductive_senescence1.02250754
101MP0000689_abnormal_spleen_morphology1.01784503
102MP0000678_abnormal_parathyroid_gland1.01519007
103MP0004019_abnormal_vitamin_homeostasis1.01490626
104MP0000350_abnormal_cell_proliferation1.00878258
105MP0005636_abnormal_mineral_homeostasis1.00619020
106MP0002837_dystrophic_cardiac_calcinosis1.00058770
107MP0000685_abnormal_immune_system0.99340707
108MP0003984_embryonic_growth_retardation0.99083680
109MP0001845_abnormal_inflammatory_respons0.99068022
110MP0003183_abnormal_peptide_metabolism0.98515427
111MP0000647_abnormal_sebaceous_gland0.97898204
112MP0002429_abnormal_blood_cell0.97670595
113MP0002722_abnormal_immune_system0.94377307
114MP0001293_anophthalmia0.93563350
115MP0001881_abnormal_mammary_gland0.93428522
116MP0003724_increased_susceptibility_to0.93116230
117MP0008260_abnormal_autophagy0.92473584
118MP0002088_abnormal_embryonic_growth/wei0.92279672
119MP0010155_abnormal_intestine_physiology0.91969454
120MP0003718_maternal_effect0.91054443
121MP0002090_abnormal_vision0.90345513
122MP0000313_abnormal_cell_death0.89954915
123MP0001905_abnormal_dopamine_level0.89789804
124MP0002909_abnormal_adrenal_gland0.89516921
125MP0003385_abnormal_body_wall0.89318558
126MP0000013_abnormal_adipose_tissue0.88704817
127MP0003786_premature_aging0.88474974
128MP0002233_abnormal_nose_morphology0.88355148
129MP0003122_maternal_imprinting0.87631275
130MP0002452_abnormal_antigen_presenting0.87248950
131MP0004808_abnormal_hematopoietic_stem0.86602982
132MP0000358_abnormal_cell_content/0.84716797
133MP0000716_abnormal_immune_system0.84548026
134MP0002405_respiratory_system_inflammati0.84461132
135MP0001756_abnormal_urination0.84328471
136MP0000681_abnormal_thyroid_gland0.84170984
137MP0001944_abnormal_pancreas_morphology0.83794369
138MP0001819_abnormal_immune_cell0.83702603
139MP0002420_abnormal_adaptive_immunity0.83357909
140MP0005000_abnormal_immune_tolerance0.83310181
141MP0001800_abnormal_humoral_immune0.82770126
142MP0005075_abnormal_melanosome_morpholog0.81515474
143MP0000377_abnormal_hair_follicle0.81495667
144MP0005084_abnormal_gallbladder_morpholo0.81103078
145MP0003943_abnormal_hepatobiliary_system0.80886720
146MP0002693_abnormal_pancreas_physiology0.79540057
147MP0002080_prenatal_lethality0.79341507
148MP0010307_abnormal_tumor_latency0.78831860
149MP0002723_abnormal_immune_serum0.77958834
150MP0005584_abnormal_enzyme/coenzyme_acti0.77212734
151MP0009763_increased_sensitivity_to0.77102699
152MP0002098_abnormal_vibrissa_morphology0.77068210
153MP0009764_decreased_sensitivity_to0.76724019
154MP0002282_abnormal_trachea_morphology0.76573412
155MP0000372_irregular_coat_pigmentation0.76256912
156MP0005645_abnormal_hypothalamus_physiol0.76077221
157MP0000750_abnormal_muscle_regeneration0.74903807
158MP0002111_abnormal_tail_morphology0.74822633
159MP0001286_abnormal_eye_development0.74215400
160MP0001243_abnormal_dermal_layer0.74139323
161MP0002234_abnormal_pharynx_morphology0.72056771
162MP0001533_abnormal_skeleton_physiology0.71962953
163MP0003937_abnormal_limbs/digits/tail_de0.71401670
164MP0003755_abnormal_palate_morphology0.70015619

Predicted human phenotypes

RankGene SetZ-score
1Abnormal mitochondria in muscle tissue (HP:0008316)4.29869508
2Acute necrotizing encephalopathy (HP:0006965)4.27525729
3Acute encephalopathy (HP:0006846)4.04951678
4Mitochondrial inheritance (HP:0001427)3.82296684
5Increased hepatocellular lipid droplets (HP:0006565)3.80936200
6Microvesicular hepatic steatosis (HP:0001414)3.73226003
7Cholecystitis (HP:0001082)3.52084164
8Abnormal gallbladder physiology (HP:0012438)3.52084164
9Aplastic anemia (HP:0001915)3.51511931
10Lipid accumulation in hepatocytes (HP:0006561)3.48337286
11Increased CSF lactate (HP:0002490)3.47355022
12Hypobetalipoproteinemia (HP:0003563)3.41681920
13Cerebral edema (HP:0002181)3.41376252
14Abnormality of aromatic amino acid family metabolism (HP:0004338)3.38722550
15Progressive macrocephaly (HP:0004481)3.37006009
16Renal Fanconi syndrome (HP:0001994)3.21816499
17Generalized aminoaciduria (HP:0002909)3.16246254
18Hypoglycemic coma (HP:0001325)3.14373698
19Abnormality of monocarboxylic acid metabolism (HP:0010996)3.06475409
20Type I transferrin isoform profile (HP:0003642)3.03048971
21Abnormality of the intrinsic pathway (HP:0010989)3.02101748
22Abnormality of pyrimidine metabolism (HP:0004353)3.00470223
23Macrocytic anemia (HP:0001972)2.98006812
24Thrombocytosis (HP:0001894)2.93758835
25Degeneration of anterior horn cells (HP:0002398)2.93540689
26Abnormality of the anterior horn cell (HP:0006802)2.93540689
27Increased intramyocellular lipid droplets (HP:0012240)2.92882193
28Reduced antithrombin III activity (HP:0001976)2.89132267
29Lactic acidosis (HP:0003128)2.79866821
30Oral leukoplakia (HP:0002745)2.76586690
313-Methylglutaconic aciduria (HP:0003535)2.70658901
32Nonimmune hydrops fetalis (HP:0001790)2.66466657
33Exercise intolerance (HP:0003546)2.64908859
34Petechiae (HP:0000967)2.64507127
35Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.62503063
36Abnormal protein N-linked glycosylation (HP:0012347)2.62503063
37Abnormal protein glycosylation (HP:0012346)2.62503063
38Abnormal glycosylation (HP:0012345)2.62503063
39Respiratory failure (HP:0002878)2.62375690
40Hyperbilirubinemia (HP:0002904)2.62323637
41Abnormality of the heme biosynthetic pathway (HP:0010472)2.60415831
42Birth length less than 3rd percentile (HP:0003561)2.57654321
43Abnormality of fatty-acid metabolism (HP:0004359)2.49541986
44Hepatic necrosis (HP:0002605)2.47704058
45Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.44642491
46Poor head control (HP:0002421)2.44576801
47Increased muscle lipid content (HP:0009058)2.42023509
48Intrahepatic cholestasis (HP:0001406)2.41392460
49Multiple enchondromatosis (HP:0005701)2.41045548
50Overlapping toe (HP:0001845)2.39938655
51Abnormality of reticulocytes (HP:0004312)2.35178342
52Hyperammonemia (HP:0001987)2.31984823
53Abnormality of the common coagulation pathway (HP:0010990)2.28438453
54Nausea (HP:0002018)2.27789521
55Cortical dysplasia (HP:0002539)2.26488264
56Prolonged partial thromboplastin time (HP:0003645)2.21327384
57Aplasia/Hypoplasia of the sacrum (HP:0008517)2.17270630
58Hypokinesia (HP:0002375)2.15963893
59Abnormality of nucleobase metabolism (HP:0010932)2.14599541
60Upper limb muscle weakness (HP:0003484)2.14463131
61Abnormality of sulfur amino acid metabolism (HP:0004339)2.13809792
62Abnormal gallbladder morphology (HP:0012437)2.13422320
63Neuroendocrine neoplasm (HP:0100634)2.12825179
64Hypoglycemic seizures (HP:0002173)2.11466592
65Cholelithiasis (HP:0001081)2.09139878
66Recurrent gram-negative bacterial infections (HP:0005420)2.08926839
67Opisthotonus (HP:0002179)2.07909376
68Orthostatic hypotension (HP:0001278)2.06735095
69Microretrognathia (HP:0000308)2.04303012
70Myoglobinuria (HP:0002913)2.02603333
71Dicarboxylic aciduria (HP:0003215)2.01408095
72Abnormality of dicarboxylic acid metabolism (HP:0010995)2.01408095
73Fat malabsorption (HP:0002630)2.01339978
74Respiratory difficulties (HP:0002880)2.01006266
75Megaloblastic anemia (HP:0001889)2.00529228
7611 pairs of ribs (HP:0000878)1.99734542
77Abnormality of methionine metabolism (HP:0010901)1.98468508
78Rough bone trabeculation (HP:0100670)1.96774149
79Increased serum lactate (HP:0002151)1.96046778
80Autoimmune thrombocytopenia (HP:0001973)1.95325694
81Leukodystrophy (HP:0002415)1.95201168
82Testicular atrophy (HP:0000029)1.94156161
83Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.93997477
84Decreased activity of mitochondrial respiratory chain (HP:0008972)1.93997477
85Abnormality of T cell physiology (HP:0011840)1.93710847
86Postnatal microcephaly (HP:0005484)1.93612475
87Abnormal number of erythroid precursors (HP:0012131)1.93238777
88Systemic lupus erythematosus (HP:0002725)1.90862666
89Emotional lability (HP:0000712)1.90768911
90IgM deficiency (HP:0002850)1.89675388
91Hyperphosphaturia (HP:0003109)1.89376620
92Hypolipoproteinemia (HP:0010981)1.88822874
93Hepatocellular necrosis (HP:0001404)1.88699566
94Reticulocytosis (HP:0001923)1.88233019
95Gout (HP:0001997)1.87860805
96Beaking of vertebral bodies (HP:0004568)1.87590952
97Abnormality of glycolysis (HP:0004366)1.86660271
98Increased serum pyruvate (HP:0003542)1.86660271
99Hyperthyroidism (HP:0000836)1.85737542
100Steatorrhea (HP:0002570)1.85534805
101Neoplasm of the adrenal gland (HP:0100631)1.85129236
102Deep venous thrombosis (HP:0002625)1.84841294
103Hyperglycinuria (HP:0003108)1.84650289
104Vacuolated lymphocytes (HP:0001922)1.84392729
105Trismus (HP:0000211)1.83133352
106Cerebral palsy (HP:0100021)1.81675787
107Hepatocellular carcinoma (HP:0001402)1.81608078
108Abnormal cartilage morphology (HP:0002763)1.80992571
109Irregular epiphyses (HP:0010582)1.80632298
110Poikilocytosis (HP:0004447)1.80531303
111Xanthomatosis (HP:0000991)1.79899378
112Unilateral renal agenesis (HP:0000122)1.78404951
113Pancytopenia (HP:0001876)1.78238258
114Abnormality of serum amino acid levels (HP:0003112)1.77705104
115Reticulocytopenia (HP:0001896)1.77150285
116Abnormality of renal resorption (HP:0011038)1.77040643
117Lethargy (HP:0001254)1.76626225
118Vertebral compression fractures (HP:0002953)1.76062658
119Carpal bone hypoplasia (HP:0001498)1.75799021
120Joint hemorrhage (HP:0005261)1.75585060
121Conjugated hyperbilirubinemia (HP:0002908)1.74670535
122Hyperglycinemia (HP:0002154)1.74549900
123Secondary amenorrhea (HP:0000869)1.74045045
124Neutropenia (HP:0001875)1.73682799
125Abnormality of urine glucose concentration (HP:0011016)1.72805310
126Glycosuria (HP:0003076)1.72805310
127Proximal tubulopathy (HP:0000114)1.72725388
128Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.72361193
129Prominent metopic ridge (HP:0005487)1.72044510
130Abnormality of purine metabolism (HP:0004352)1.71664201
131Elevated erythrocyte sedimentation rate (HP:0003565)1.71561087
132Breast hypoplasia (HP:0003187)1.71126511
133Abnormalities of placenta or umbilical cord (HP:0001194)1.70529956
134Abnormality of aspartate family amino acid metabolism (HP:0010899)1.70376980
135Metabolic acidosis (HP:0001942)1.69561528
136Rhabdomyolysis (HP:0003201)1.68894109
137Hand muscle atrophy (HP:0009130)1.68591261
138Poor suck (HP:0002033)1.68529845
139Premature rupture of membranes (HP:0001788)1.68186341
140Bone marrow hypocellularity (HP:0005528)1.67813895
141Hypoplastic pelvis (HP:0008839)1.67596379
142Ketosis (HP:0001946)1.67585338
143Abnormality of cells of the erythroid lineage (HP:0012130)1.66731941
144Neoplasm of the peripheral nervous system (HP:0100007)1.65718300
145Abnormality of the gallbladder (HP:0005264)1.65397051
146Complement deficiency (HP:0004431)1.65287651
147Insidious onset (HP:0003587)1.64601605
148Termporal pattern (HP:0011008)1.64601605
149Late onset (HP:0003584)1.64580554
150Recurrent abscess formation (HP:0002722)1.64439919
151CNS demyelination (HP:0007305)1.64343674
152Villous atrophy (HP:0011473)1.63443607
153Abnormality of small intestinal villus morphology (HP:0011472)1.63443607
154Truncus arteriosus (HP:0001660)1.63365370
155Abnormality of endocrine pancreas physiology (HP:0012093)1.63159736
156Abnormality of the pancreatic islet cells (HP:0006476)1.63159736
157Ragged-red muscle fibers (HP:0003200)1.62652669
158Exertional dyspnea (HP:0002875)1.62534409
159Symptomatic seizures (HP:0011145)1.62293373
160Anorexia (HP:0002039)1.61621052
161Congenital primary aphakia (HP:0007707)1.61567142
162Pallor (HP:0000980)1.61276653
163Abnormality of dentin (HP:0010299)1.58197836
164Adrenal hypoplasia (HP:0000835)1.57944376

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.05642941
2EIF2AK13.53087308
3BUB13.17500568
4STK162.89205950
5BCKDK2.80540842
6PASK2.60752453
7EIF2AK32.52554962
8WEE12.38190197
9TSSK62.24803604
10NME12.23868178
11ERN12.11029410
12CDC71.95523313
13NME21.88685255
14TESK11.88317816
15MST1R1.83654029
16ACVR1B1.80512244
17IRAK31.76125717
18NEK11.75611480
19BRSK21.74051770
20PIM21.73112614
21PLK41.72312221
22TGFBR11.64516901
23TESK21.53965669
24ZAP701.49832294
25MAP4K11.46866156
26VRK11.45731256
27EPHA31.45317140
28PDK21.44444048
29SCYL21.43974713
30ILK1.43428202
31FLT31.43305113
32SRPK11.39545469
33IRAK41.38985914
34MAP2K71.38745237
35RPS6KA41.37696020
36CSNK1G31.35419814
37BRSK11.33733409
38BCR1.31535214
39EPHB21.19552457
40MAP3K111.18595166
41STK101.16908717
42KDR1.16619348
43NEK91.15017453
44PLK11.12640250
45PLK31.12581801
46RPS6KB21.12409405
47ATR1.11416409
48NEK21.10273505
49LMTK21.09731202
50TYK21.05424259
51ERBB31.04221000
52CDK71.02794275
53MAP3K121.00887234
54CDK80.99363598
55BTK0.99192082
56AURKB0.98857409
57TRIM280.98676065
58CCNB10.98626703
59AKT30.98228004
60TTK0.97811869
61MAPKAPK30.96911926
62PAK40.96710541
63EPHB10.96601254
64CSNK1A1L0.95891355
65KIT0.94537774
66TAOK30.93794695
67PIM10.93538807
68CDK190.93201781
69MAP2K30.92622038
70MET0.92140023
71TBK10.92050340
72JAK30.90513154
73AURKA0.89183083
74CSNK1G10.89151703
75TEC0.88745084
76BRAF0.87821765
77ZAK0.87632124
78ARAF0.85790262
79TXK0.84860839
80BLK0.84588190
81CSNK1G20.84558368
82DYRK30.83867114
83SIK30.82746983
84DYRK20.80561851
85TAOK20.80001773
86LIMK10.79916904
87MAP3K80.78512224
88EIF2AK20.77383415
89PBK0.77265426
90DAPK10.77149761
91FER0.73640992
92ERBB40.71963688
93FGFR40.71523297
94CDK140.69611594
95MAPKAPK50.68505267
96PKN20.67118911
97MYLK0.66765928
98IKBKE0.66758293
99EPHA20.66048110
100AKT20.65866063
101LRRK20.64697835
102MAP3K30.64674941
103MKNK10.63971261
104EEF2K0.63139522
105PTK20.63052968
106CDK40.62899406
107ABL20.62882683
108MAP3K140.62307646
109MAP4K20.62101562
110CSNK2A10.62092993
111MAP3K40.61978639
112DAPK30.61368103
113PAK10.60794445
114MAPK110.60689954
115RAF10.60448397
116STK40.59929385
117TRIB30.59847252
118TGFBR20.58764625
119CDK11A0.58672122
120KSR10.57846799
121LYN0.56246824
122IKBKB0.56136937
123CHUK0.56125826
124SYK0.54919365
125PIK3CG0.54432183
126CDK180.54349723
127CSF1R0.53439631
128BMPR1B0.52062599
129CDK150.51322940
130CHEK20.50545295
131CLK10.50264409
132KSR20.50063401
133PHKG20.49908649
134PHKG10.49908649
135MAP3K50.49892027
136PRKCI0.49825346
137MST40.49461334
138PRKG20.48682647
139BMX0.48351488
140ICK0.47008628
141STK38L0.45907846
142RPS6KB10.45068656
143CSNK2A20.44067090
144STK240.43065599
145MAP2K60.42899516
146SMG10.42358838
147CAMK2G0.34986740
148CHEK10.33961324

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.39397724
2Proteasome_Homo sapiens_hsa030503.20491617
3Oxidative phosphorylation_Homo sapiens_hsa001903.15471914
4Protein export_Homo sapiens_hsa030602.78044856
5Parkinsons disease_Homo sapiens_hsa050122.77341367
6Mismatch repair_Homo sapiens_hsa034302.69594590
7One carbon pool by folate_Homo sapiens_hsa006702.54034389
8Base excision repair_Homo sapiens_hsa034102.27758246
9Fatty acid elongation_Homo sapiens_hsa000622.23122911
10Selenocompound metabolism_Homo sapiens_hsa004502.01322655
11Folate biosynthesis_Homo sapiens_hsa007901.98669806
12Huntingtons disease_Homo sapiens_hsa050161.96485475
13Pyrimidine metabolism_Homo sapiens_hsa002401.92707517
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.86710562
15RNA polymerase_Homo sapiens_hsa030201.84993485
16Drug metabolism - other enzymes_Homo sapiens_hsa009831.83015343
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.77936629
18Nucleotide excision repair_Homo sapiens_hsa034201.76031833
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.71848032
20Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.70729920
21Alzheimers disease_Homo sapiens_hsa050101.70060896
22Homologous recombination_Homo sapiens_hsa034401.65720325
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.65139675
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.62447239
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.61976811
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.58238422
27Steroid biosynthesis_Homo sapiens_hsa001001.56527482
28Spliceosome_Homo sapiens_hsa030401.55785698
29RNA transport_Homo sapiens_hsa030131.54398766
30Ribosome_Homo sapiens_hsa030101.51537912
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.49384907
32Vibrio cholerae infection_Homo sapiens_hsa051101.47783456
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.47526911
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.47109588
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45551945
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.44110033
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42098867
38Cell cycle_Homo sapiens_hsa041101.40742130
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.36426276
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.35347502
41Biosynthesis of amino acids_Homo sapiens_hsa012301.33346615
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32205735
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.27064756
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26292449
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23114688
46Pentose phosphate pathway_Homo sapiens_hsa000301.22170297
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.21566071
48Peroxisome_Homo sapiens_hsa041461.20247862
49Non-homologous end-joining_Homo sapiens_hsa034501.20004367
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18680552
51Carbon metabolism_Homo sapiens_hsa012001.18435676
52Tryptophan metabolism_Homo sapiens_hsa003801.17015763
53Legionellosis_Homo sapiens_hsa051341.16815643
54Fatty acid degradation_Homo sapiens_hsa000711.13374370
55Galactose metabolism_Homo sapiens_hsa000521.12962480
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.11594992
57N-Glycan biosynthesis_Homo sapiens_hsa005101.10039712
58Sulfur relay system_Homo sapiens_hsa041221.04375108
59RNA degradation_Homo sapiens_hsa030181.01650537
60Glutathione metabolism_Homo sapiens_hsa004801.01236304
61Other glycan degradation_Homo sapiens_hsa005110.97813601
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97144919
63Caffeine metabolism_Homo sapiens_hsa002320.94964737
64Fructose and mannose metabolism_Homo sapiens_hsa000510.94303479
65Sulfur metabolism_Homo sapiens_hsa009200.92838524
66Collecting duct acid secretion_Homo sapiens_hsa049660.90171073
67Pyruvate metabolism_Homo sapiens_hsa006200.88068494
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87931262
69Purine metabolism_Homo sapiens_hsa002300.87402973
70Cardiac muscle contraction_Homo sapiens_hsa042600.86084027
71Antigen processing and presentation_Homo sapiens_hsa046120.85623349
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.82694131
73p53 signaling pathway_Homo sapiens_hsa041150.82436013
74Complement and coagulation cascades_Homo sapiens_hsa046100.82382864
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80785883
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79691974
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79280903
78Chemical carcinogenesis_Homo sapiens_hsa052040.74700037
79Phenylalanine metabolism_Homo sapiens_hsa003600.73792518
80beta-Alanine metabolism_Homo sapiens_hsa004100.73299971
81Starch and sucrose metabolism_Homo sapiens_hsa005000.72825080
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71357755
83Basal transcription factors_Homo sapiens_hsa030220.71318532
84Vitamin B6 metabolism_Homo sapiens_hsa007500.69023168
85Arginine biosynthesis_Homo sapiens_hsa002200.68514622
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68479199
87Propanoate metabolism_Homo sapiens_hsa006400.67132303
88Fat digestion and absorption_Homo sapiens_hsa049750.66210283
89Histidine metabolism_Homo sapiens_hsa003400.66048120
90Epstein-Barr virus infection_Homo sapiens_hsa051690.64821044
91Staphylococcus aureus infection_Homo sapiens_hsa051500.64651489
92Fanconi anemia pathway_Homo sapiens_hsa034600.63373737
93Vitamin digestion and absorption_Homo sapiens_hsa049770.62854452
94Herpes simplex infection_Homo sapiens_hsa051680.58796575
95Metabolic pathways_Homo sapiens_hsa011000.55913778
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.54163307
97Tyrosine metabolism_Homo sapiens_hsa003500.53245014
98mRNA surveillance pathway_Homo sapiens_hsa030150.52709860
99Retinol metabolism_Homo sapiens_hsa008300.52452257
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51454280
101Fatty acid metabolism_Homo sapiens_hsa012120.51016378
102Arginine and proline metabolism_Homo sapiens_hsa003300.47064037
103Lysosome_Homo sapiens_hsa041420.46318028
104Regulation of autophagy_Homo sapiens_hsa041400.44870336
105Renin-angiotensin system_Homo sapiens_hsa046140.44505774
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44337630
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43342604
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41182950
109Synaptic vesicle cycle_Homo sapiens_hsa047210.40664835
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39438439
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.38702678
112Measles_Homo sapiens_hsa051620.37815643
113Thyroid cancer_Homo sapiens_hsa052160.35535419
114Arachidonic acid metabolism_Homo sapiens_hsa005900.35358592
115Butanoate metabolism_Homo sapiens_hsa006500.33886952
116Viral carcinogenesis_Homo sapiens_hsa052030.33722064
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.33192423
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30902852
119Apoptosis_Homo sapiens_hsa042100.30091255
120Oocyte meiosis_Homo sapiens_hsa041140.27667716
121Shigellosis_Homo sapiens_hsa051310.25232046
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.12458314
123Hippo signaling pathway_Homo sapiens_hsa043900.10328152

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