COPZ2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the adaptor complexes small subunit family. The encoded protein is a subunit of the coatomer protein complex, a seven-subunit complex that functions in the formation of COPI-type, non-clathrin-coated vesicles. COPI vesicles function in the retrograde Golgi-to-ER transport of dilysine-tagged proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)7.97164042
2doxorubicin metabolic process (GO:0044598)7.97164042
3daunorubicin metabolic process (GO:0044597)7.97164042
4protein retention in ER lumen (GO:0006621)5.15247512
5aminoglycoside antibiotic metabolic process (GO:0030647)5.12671144
6maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.02000432
7cell migration involved in heart development (GO:0060973)4.97276762
8cellular modified amino acid catabolic process (GO:0042219)4.87215295
9skin morphogenesis (GO:0043589)4.87085710
10notochord development (GO:0030903)4.76968258
11bone trabecula formation (GO:0060346)4.76794527
12endodermal cell differentiation (GO:0035987)4.75486735
13type B pancreatic cell proliferation (GO:0044342)4.73222850
14extracellular fibril organization (GO:0043206)4.72408136
15coenzyme catabolic process (GO:0009109)4.67573129
16sequestering of extracellular ligand from receptor (GO:0035581)4.65762521
17muscle organ morphogenesis (GO:0048644)4.55670060
18adhesion of symbiont to host cell (GO:0044650)4.50603317
19virion attachment to host cell (GO:0019062)4.50603317
20hormone catabolic process (GO:0042447)4.46135699
21negative regulation of epidermis development (GO:0045683)4.44512756
22extracellular matrix assembly (GO:0085029)4.44115044
23epoxygenase P450 pathway (GO:0019373)4.43483748
24exocrine pancreas development (GO:0031017)4.40971308
25keratan sulfate catabolic process (GO:0042340)4.35047393
26maintenance of protein localization in organelle (GO:0072595)4.26906341
27fibril organization (GO:0097435)4.22007692
28sulfur amino acid catabolic process (GO:0000098)4.15680172
29regulation of apoptotic process involved in morphogenesis (GO:1902337)4.06351104
30kidney mesenchyme development (GO:0072074)4.06054076
31regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.04076815
32valine metabolic process (GO:0006573)4.00788694
33negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.99477704
34somite rostral/caudal axis specification (GO:0032525)3.99158755
35negative regulation of smooth muscle cell migration (GO:0014912)3.91930358
36barbed-end actin filament capping (GO:0051016)3.89012312
37adhesion of symbiont to host (GO:0044406)3.88996307
38collagen metabolic process (GO:0032963)3.85117925
39regulation of response to osmotic stress (GO:0047484)3.84253494
40maintenance of protein location in nucleus (GO:0051457)3.76843614
41cellular response to vitamin (GO:0071295)3.74988044
42chondrocyte proliferation (GO:0035988)3.74775285
43metanephric mesenchyme development (GO:0072075)3.73834037
44biotin metabolic process (GO:0006768)3.70465314
45collagen catabolic process (GO:0030574)3.68197089
46regulation of plasminogen activation (GO:0010755)3.64219263
47peptidyl-proline hydroxylation (GO:0019511)3.64080024
48negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.60149986
49COPI coating of Golgi vesicle (GO:0048205)3.56749318
50Golgi transport vesicle coating (GO:0048200)3.56749318
51multicellular organismal macromolecule metabolic process (GO:0044259)3.55572424
52blood vessel maturation (GO:0001955)3.50712837
53regulation of mammary gland epithelial cell proliferation (GO:0033599)3.50161025
54intestinal epithelial cell development (GO:0060576)3.50100607
55cytidine deamination (GO:0009972)3.47131981
56cytidine metabolic process (GO:0046087)3.47131981
57cytidine catabolic process (GO:0006216)3.47131981
58intestinal cholesterol absorption (GO:0030299)3.46683252
59tooth mineralization (GO:0034505)3.43941816
60vascular endothelial growth factor signaling pathway (GO:0038084)3.41987078
61pyrimidine ribonucleoside catabolic process (GO:0046133)3.41223239
62multicellular organismal metabolic process (GO:0044236)3.39049402
63omega-hydroxylase P450 pathway (GO:0097267)3.35820495
64multicellular organismal catabolic process (GO:0044243)3.35278060
65negative regulation of epidermal cell differentiation (GO:0045605)3.34125605
66positive regulation of endothelial cell apoptotic process (GO:2000353)3.33029070
67cell adhesion mediated by integrin (GO:0033627)3.32156319
68extracellular matrix disassembly (GO:0022617)3.32136487
69collagen fibril organization (GO:0030199)3.30069582
70regulation of glucose import in response to insulin stimulus (GO:2001273)3.29193971
71maternal placenta development (GO:0001893)3.28736793
72stress fiber assembly (GO:0043149)3.28180035
73branched-chain amino acid catabolic process (GO:0009083)3.27868396
74GDP-mannose metabolic process (GO:0019673)3.27642899
75phagocytosis, recognition (GO:0006910)3.24713171
76primitive streak formation (GO:0090009)3.24678935
77phenol-containing compound catabolic process (GO:0019336)3.19352845
78regulation of extracellular matrix disassembly (GO:0010715)3.18832146
79positive regulation of histone deacetylation (GO:0031065)3.18445691
80branching involved in mammary gland duct morphogenesis (GO:0060444)3.17788138
81positive regulation of blood vessel endothelial cell migration (GO:0043536)3.17617589
82glomerular basement membrane development (GO:0032836)3.15072311
83intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.14802931
84regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.14122195
85mesenchymal-epithelial cell signaling (GO:0060638)3.12497221
86cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.10640248
87substrate-dependent cell migration (GO:0006929)3.09970410
88retinoic acid receptor signaling pathway (GO:0048384)3.09178989
89cell-substrate junction assembly (GO:0007044)3.08717536
90negative regulation of cell cycle G2/M phase transition (GO:1902750)3.07262597
91endocardial cushion development (GO:0003197)3.06510739
92activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.06238449
93apoptotic cell clearance (GO:0043277)3.05774599
94venous blood vessel morphogenesis (GO:0048845)3.05659318
95mitochondrion distribution (GO:0048311)3.04697296
96protein hydroxylation (GO:0018126)3.03481813
97extracellular matrix organization (GO:0030198)3.02915218
98protein heterotrimerization (GO:0070208)3.02615208
99peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.02499225
100response to dietary excess (GO:0002021)3.02460687
101extracellular structure organization (GO:0043062)3.01783325
102extracellular negative regulation of signal transduction (GO:1900116)3.00163895
103extracellular regulation of signal transduction (GO:1900115)3.00163895
104rRNA transcription (GO:0009303)2.99533699
105actin-myosin filament sliding (GO:0033275)2.99449591
106muscle filament sliding (GO:0030049)2.99449591
107positive regulation of protein deacetylation (GO:0090312)2.98456346
108positive regulation of extracellular matrix organization (GO:1903055)2.97420222
109nucleotide-sugar biosynthetic process (GO:0009226)2.95995814
110quinone metabolic process (GO:1901661)2.95198373
111regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.95169716
112endothelial cell morphogenesis (GO:0001886)2.94955843
113vitamin A metabolic process (GO:0006776)2.94183979
114negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.93312946
115actin-mediated cell contraction (GO:0070252)2.93278015
116branched-chain amino acid metabolic process (GO:0009081)2.92318419
117nucleoside transmembrane transport (GO:1901642)2.89343647
118negative regulation of telomerase activity (GO:0051974)2.89081782
119cell proliferation involved in metanephros development (GO:0072203)2.88430927
120positive regulation of nuclease activity (GO:0032075)2.86795292
121UDP-N-acetylglucosamine metabolic process (GO:0006047)2.83222133
122regulation of early endosome to late endosome transport (GO:2000641)2.82767948
123regulation of integrin-mediated signaling pathway (GO:2001044)2.81576045
124regulation of MHC class I biosynthetic process (GO:0045343)2.81005491
125vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.80663582
126retina vasculature morphogenesis in camera-type eye (GO:0061299)2.80472910
127hyaluronan catabolic process (GO:0030214)2.79920633
128dermatan sulfate biosynthetic process (GO:0030208)2.76226851
129dermatan sulfate metabolic process (GO:0030205)2.75989475
130negative regulation of chondrocyte differentiation (GO:0032331)2.74583840
131polarized epithelial cell differentiation (GO:0030859)2.71969751
132chondrocyte development (GO:0002063)2.70969991
133icosanoid secretion (GO:0032309)2.70210531
134arachidonic acid secretion (GO:0050482)2.70210531
135hemidesmosome assembly (GO:0031581)2.70050526
136negative regulation of nitric-oxide synthase activity (GO:0051001)2.67186038
137COPII vesicle coating (GO:0048208)2.66306776
138negative regulation of fatty acid transport (GO:2000192)2.65939616
139positive regulation of osteoblast proliferation (GO:0033690)2.65834699
140sulfur compound catabolic process (GO:0044273)2.65002659
141endoplasmic reticulum unfolded protein response (GO:0030968)2.63022290
1424-hydroxyproline metabolic process (GO:0019471)2.62916318
143heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.61474211
144transcytosis (GO:0045056)2.61113550
145cellular response to amino acid stimulus (GO:0071230)2.59529078
146protein localization to cell surface (GO:0034394)2.59330122
147digestion (GO:0007586)2.59041198
148negative regulation of BMP signaling pathway (GO:0030514)2.58670797
149cofactor catabolic process (GO:0051187)2.58233791
150positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.57811668
151response to endoplasmic reticulum stress (GO:0034976)2.57753131
152regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.57231726
153focal adhesion assembly (GO:0048041)2.57211079
154cell-substrate adherens junction assembly (GO:0007045)2.57211079
155negative regulation of leukocyte chemotaxis (GO:0002689)2.56950499
156negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.56793522
157cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.55353466
158regulation of collagen metabolic process (GO:0010712)2.55036677
159cellular response to unfolded protein (GO:0034620)2.54617721
160negative regulation of cell size (GO:0045792)2.54574290
161negative regulation of homotypic cell-cell adhesion (GO:0034111)2.54530370
162regulation of smooth muscle cell migration (GO:0014910)2.53965058
163positive regulation of astrocyte differentiation (GO:0048711)2.53911613
164positive regulation of fibroblast migration (GO:0010763)2.52688887
165wound healing, spreading of epidermal cells (GO:0035313)2.52607553
166regulation of nuclease activity (GO:0032069)2.52344436
167L-ascorbic acid metabolic process (GO:0019852)2.51629456
168adherens junction assembly (GO:0034333)2.51469067
169cofactor transport (GO:0051181)2.50235251
170positive regulation of axon extension (GO:0045773)2.49529425
171basement membrane organization (GO:0071711)2.49419826
172regulation of translation in response to stress (GO:0043555)2.49343419
173negative regulation of cartilage development (GO:0061037)2.48805920
174middle ear morphogenesis (GO:0042474)2.48802013
175hypotonic response (GO:0006971)2.48401577
176regulation of telomere maintenance via telomerase (GO:0032210)2.47790573
177cellular response to vitamin D (GO:0071305)2.47336812
178negative regulation of potassium ion transmembrane transport (GO:1901380)2.46754467
179regulation of apoptotic cell clearance (GO:2000425)2.46640603
180regulation of membrane protein ectodomain proteolysis (GO:0051043)2.45783085
181intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.45128626
182regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.44512583
183negative regulation of cell fate commitment (GO:0010454)2.43358833
184positive regulation of smoothened signaling pathway (GO:0045880)2.42187600

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.93050969
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.93050969
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.93050969
4BP1_19119308_ChIP-ChIP_Hs578T_Human5.28066042
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.69562767
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.31077261
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.91790312
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.62331958
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.56971231
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.55143578
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.54850691
12HIF1A_21447827_ChIP-Seq_MCF-7_Human2.50672098
13SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.42504188
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.35999693
15* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.18040947
16CJUN_26792858_Chip-Seq_BT549_Human2.17105169
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.15951174
18RXR_22158963_ChIP-Seq_LIVER_Mouse2.12949478
19SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.10042185
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.08255835
21EP300_21415370_ChIP-Seq_HL-1_Mouse2.05083332
22NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.03024601
23PPARA_22158963_ChIP-Seq_LIVER_Mouse1.95263913
24* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.94264330
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.94221228
26CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.93732352
27RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.81663986
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.77035960
29SMC1_22415368_ChIP-Seq_MEFs_Mouse1.76293110
30LXR_22158963_ChIP-Seq_LIVER_Mouse1.74659733
31NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.71088867
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70122496
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.70111591
34STAT3_1855785_ChIP-Seq_MESCs_Mouse1.69394363
35* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.69311375
36TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67397629
37SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.64662065
38CLOCK_20551151_ChIP-Seq_293T_Human1.63211706
39SMC3_22415368_ChIP-Seq_MEFs_Mouse1.62016154
40ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.61895779
41NRF2_20460467_ChIP-Seq_MEFs_Mouse1.59449777
42NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.59449777
43CDX2_20551321_ChIP-Seq_CACO-2_Human1.57592497
44SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.53556105
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.53518000
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49810737
47SA1_22415368_ChIP-Seq_MEFs_Mouse1.49730233
48* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.49681050
49JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49283007
50JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.48851974
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.48664041
52FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.47052912
53EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.45733639
54FOXO3_23340844_ChIP-Seq_DLD1_Human1.42686165
55UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41923812
56KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37873854
57NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.36769652
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36685479
59SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.35530515
60SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.35530515
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.35365741
62TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33915536
63NFIB_24661679_ChIP-Seq_LUNG_Mouse1.33024315
64WT1_19549856_ChIP-ChIP_CCG9911_Human1.31820182
65RACK7_27058665_Chip-Seq_MCF-7_Human1.31115897
66EZH2_18974828_ChIP-Seq_MESCs_Mouse1.30189003
67RNF2_18974828_ChIP-Seq_MESCs_Mouse1.30189003
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29772981
69SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27999851
70SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27626705
71TP53_18474530_ChIP-ChIP_U2OS_Human1.26588573
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25809652
73NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.25687399
74UBF1/2_26484160_Chip-Seq_HMECs_Human1.25294455
75MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.23761371
76SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.23744249
77NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.22323714
78TP53_23651856_ChIP-Seq_MEFs_Mouse1.20940327
79LXR_22292898_ChIP-Seq_THP-1_Human1.19684357
80MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19302105
81SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18083398
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17925143
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17768111
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17601799
85TP53_22127205_ChIP-Seq_IMR90_Human1.16250821
86NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14506723
87TP53_20018659_ChIP-ChIP_R1E_Mouse1.13936055
88* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13533893
89TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.11356830
90POU5F1_16518401_ChIP-PET_MESCs_Mouse1.11344677
91IRF1_19129219_ChIP-ChIP_H3396_Human1.09154296
92NCOR1_26117541_ChIP-Seq_K562_Human1.06849686
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05589570
94RAD21_21589869_ChIP-Seq_MESCs_Mouse1.05399334
95* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.04900037
96KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04564806
97GATA3_24758297_ChIP-Seq_MCF-7_Human1.04338244
98Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02674520
99ATF3_27146783_Chip-Seq_COLON_Human1.02574630
100TP53_16413492_ChIP-PET_HCT116_Human1.02315995
101SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01954678
102* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01635235
103MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00440972
104ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98927704
105PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97729618
106PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.96956062
107NANOG_16518401_ChIP-PET_MESCs_Mouse0.96579848
108JARID2_20075857_ChIP-Seq_MESCs_Mouse0.96395066
109GATA6_25053715_ChIP-Seq_YYC3_Human0.96206408
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95900404
111GATA4_25053715_ChIP-Seq_YYC3_Human0.95602348
112PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.93917237
113SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93128938
114KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93044042
115THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92232039
116P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92216940
117* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91546071
118NANOG_16153702_ChIP-ChIP_HESCs_Human0.91396197
119SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.91324291
120SOX2_20726797_ChIP-Seq_SW620_Human0.90873922
121* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90860863
122* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90242763
123KDM2B_26808549_Chip-Seq_K562_Human0.89415694
124SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89240011
125FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.89137364
126SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.88997212
127TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88893050
128* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.88038346
129RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87822349
130ERG_21242973_ChIP-ChIP_JURKAT_Human0.87766632
131SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87586121
132NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.87493671
133* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.87349950
134CTCF_21964334_Chip-Seq_Bcells_Human0.87043215
135PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86681080
136ZNF263_19887448_ChIP-Seq_K562_Human0.86611508
137CSB_26484114_Chip-Seq_FIBROBLAST_Human0.86605003
138TBX20_22080862_ChIP-Seq_HEART_Mouse0.84820635
139TBX20_22328084_ChIP-Seq_HEART_Mouse0.84820635
140BRD4_25478319_ChIP-Seq_HGPS_Human0.84269146
141TBX3_20139965_ChIP-Seq_ESCs_Mouse0.83968694
142TBX3_20139965_ChIP-Seq_MESCs_Mouse0.83499793
143SMC4_20622854_ChIP-Seq_HELA_Human0.82734964
144P300_27058665_Chip-Seq_ZR-75-30cells_Human0.81962048
145STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.81625907
146GATA2_21666600_ChIP-Seq_HMVEC_Human0.81044971
147* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.80598854
148KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80100017
149PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79418864
150CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.78822711
151TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.77007977
152ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.75134761
153ELK1_22589737_ChIP-Seq_MCF10A_Human0.72371982

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.58986722
2MP0003705_abnormal_hypodermis_morpholog4.37845490
3MP0005503_abnormal_tendon_morphology3.24154239
4MP0004264_abnormal_extraembryonic_tissu3.23960231
5MP0002254_reproductive_system_inflammat3.21111928
6MP0005275_abnormal_skin_tensile2.89132074
7MP0000751_myopathy2.86130614
8MP0003011_delayed_dark_adaptation2.81427305
9MP0005257_abnormal_intraocular_pressure2.76409636
10MP0004272_abnormal_basement_membrane2.25130383
11MP0003279_aneurysm2.24590417
12MP0005365_abnormal_bile_salt2.04026385
13MP0005508_abnormal_skeleton_morphology2.03520644
14MP0003950_abnormal_plasma_membrane1.90369465
15MP0004858_abnormal_nervous_system1.89915055
16MP0010030_abnormal_orbit_morphology1.89335041
17MP0003122_maternal_imprinting1.86741002
18MP0005083_abnormal_biliary_tract1.75391698
19MP0001666_abnormal_nutrient_absorption1.66844428
20MP0000678_abnormal_parathyroid_gland1.61506465
21MP0009384_cardiac_valve_regurgitation1.55267062
22MP0003091_abnormal_cell_migration1.54599853
23MP0005220_abnormal_exocrine_pancreas1.53663575
24MP0002332_abnormal_exercise_endurance1.51657515
25MP0000163_abnormal_cartilage_morphology1.51024504
26MP0000762_abnormal_tongue_morphology1.49280000
27MP0010368_abnormal_lymphatic_system1.49267329
28MP0009250_abnormal_appendicular_skeleto1.48763932
29MP0002932_abnormal_joint_morphology1.48721713
30MP0005023_abnormal_wound_healing1.47638222
31MP0010352_gastrointestinal_tract_polyps1.47473278
32MP0003283_abnormal_digestive_organ1.45492915
33MP0000750_abnormal_muscle_regeneration1.40244440
34MP0000049_abnormal_middle_ear1.35272369
35MP0002108_abnormal_muscle_morphology1.33535966
36MP0009780_abnormal_chondrocyte_physiolo1.32275492
37MP0005499_abnormal_olfactory_system1.31666551
38MP0005394_taste/olfaction_phenotype1.31666551
39MP0005595_abnormal_vascular_smooth1.30422809
40MP0003890_abnormal_embryonic-extraembry1.30058905
41MP0001299_abnormal_eye_distance/1.29186788
42MP0005670_abnormal_white_adipose1.28871189
43MP0000749_muscle_degeneration1.28285473
44MP0000733_abnormal_muscle_development1.26345584
45MP0002139_abnormal_hepatobiliary_system1.24468557
46MP0003566_abnormal_cell_adhesion1.24151912
47MP0006292_abnormal_olfactory_placode1.23045924
48MP0002877_abnormal_melanocyte_morpholog1.21489110
49MP0005058_abnormal_lysosome_morphology1.21001430
50MP0001243_abnormal_dermal_layer1.18028540
51MP0002295_abnormal_pulmonary_circulatio1.16410660
52MP0003941_abnormal_skin_development1.13334478
53MP0002060_abnormal_skin_morphology1.12508105
54MP0004036_abnormal_muscle_relaxation1.12224661
55MP0000747_muscle_weakness1.12131174
56MP0000428_abnormal_craniofacial_morphol1.10783064
57MP0001542_abnormal_bone_strength1.10623209
58MP0004087_abnormal_muscle_fiber1.10230637
59MP0004233_abnormal_muscle_weight1.09512389
60MP0001958_emphysema1.08923526
61MP0001270_distended_abdomen1.07357601
62MP0008961_abnormal_basal_metabolism1.06803756
63MP0002127_abnormal_cardiovascular_syste1.06751013
64MP0005390_skeleton_phenotype1.06362408
65MP0005248_abnormal_Harderian_gland1.06321491
66MP0005369_muscle_phenotype1.05409204
67MP0002896_abnormal_bone_mineralization1.05166693
68MP0002233_abnormal_nose_morphology1.04031503
69MP0005164_abnormal_response_to1.03807411
70MP0002249_abnormal_larynx_morphology1.02785808
71MP0001849_ear_inflammation1.02234070
72MP0005085_abnormal_gallbladder_physiolo1.01616565
73MP0003755_abnormal_palate_morphology1.00194479
74MP0009840_abnormal_foam_cell0.99865176
75MP0002115_abnormal_skeleton_extremities0.98939413
76MP0006054_spinal_hemorrhage0.98056101
77MP0005319_abnormal_enzyme/_coenzyme0.97884757
78MP0002933_joint_inflammation0.95916113
79MP0003942_abnormal_urinary_system0.95855688
80MP0002277_abnormal_respiratory_mucosa0.95322162
81MP0000432_abnormal_head_morphology0.95013689
82MP0010386_abnormal_urinary_bladder0.92856396
83MP0000767_abnormal_smooth_muscle0.92056996
84MP0003183_abnormal_peptide_metabolism0.91969056
85MP0003795_abnormal_bone_structure0.91625769
86MP0004084_abnormal_cardiac_muscle0.91342246
87MP0000534_abnormal_ureter_morphology0.91058819
88MP0003935_abnormal_craniofacial_develop0.90806236
89MP0005620_abnormal_muscle_contractility0.90801025
90MP0005075_abnormal_melanosome_morpholog0.90566381
91MP0003191_abnormal_cellular_cholesterol0.90356785
92MP0002998_abnormal_bone_remodeling0.89676927
93MP0003252_abnormal_bile_duct0.88906356
94MP0005171_absent_coat_pigmentation0.88406954
95MP0002114_abnormal_axial_skeleton0.87918920
96MP0005165_increased_susceptibility_to0.87823671
97MP0003186_abnormal_redox_activity0.87313742
98MP0005623_abnormal_meninges_morphology0.86413051
99MP0002109_abnormal_limb_morphology0.86111833
100MP0002116_abnormal_craniofacial_bone0.85962273
101MP0002269_muscular_atrophy0.85289085
102MP0002088_abnormal_embryonic_growth/wei0.85107181
103MP0001348_abnormal_lacrimal_gland0.82988029
104MP0004130_abnormal_muscle_cell0.82874130
105MP0002113_abnormal_skeleton_development0.82736158
106MP0003448_altered_tumor_morphology0.82586619
107MP0004043_abnormal_pH_regulation0.82210512
108MP0002837_dystrophic_cardiac_calcinosis0.81861674
109MP0003984_embryonic_growth_retardation0.81813408
110MP0002970_abnormal_white_adipose0.81584709
111MP0001879_abnormal_lymphatic_vessel0.81236726
112MP0002106_abnormal_muscle_physiology0.81190125
113MP0002971_abnormal_brown_adipose0.80626758
114MP0004185_abnormal_adipocyte_glucose0.79747113
115MP0005330_cardiomyopathy0.79392467
116MP0004145_abnormal_muscle_electrophysio0.77494551
117MP0002128_abnormal_blood_circulation0.76848550
118MP0000013_abnormal_adipose_tissue0.76008564
119MP0002925_abnormal_cardiovascular_devel0.75481472
120MP0000003_abnormal_adipose_tissue0.75334681
121MP0003868_abnormal_feces_composition0.75030695
122MP0001672_abnormal_embryogenesis/_devel0.74727166
123MP0005380_embryogenesis_phenotype0.74727166
124MP0000759_abnormal_skeletal_muscle0.74644822
125MP0006035_abnormal_mitochondrial_morpho0.74592251
126MP0001533_abnormal_skeleton_physiology0.74304030
127MP0003385_abnormal_body_wall0.73854491
128MP0002092_abnormal_eye_morphology0.73796863
129MP0002111_abnormal_tail_morphology0.73050356
130MP0000343_altered_response_to0.72606730
131MP0005666_abnormal_adipose_tissue0.72201193
132MP0006138_congestive_heart_failure0.72153503
133MP0001661_extended_life_span0.71736727
134MP0004883_abnormal_blood_vessel0.70786917
135MP0004510_myositis0.70674113
136MP0003828_pulmonary_edema0.70537375
137MP0005388_respiratory_system_phenotype0.67710173
138MP0002133_abnormal_respiratory_system0.67710173
139MP0004134_abnormal_chest_morphology0.67469678
140MP0005375_adipose_tissue_phenotype0.67422916
141MP0009053_abnormal_anal_canal0.66629421
142MP0001614_abnormal_blood_vessel0.63882841
143MP0003300_gastrointestinal_ulcer0.63560959
144MP0003959_abnormal_lean_body0.62594684
145MP0000858_altered_metastatic_potential0.60955715
146MP0005197_abnormal_uvea_morphology0.59173583
147MP0002972_abnormal_cardiac_muscle0.58518305
148MP0003646_muscle_fatigue0.56115812

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.38033175
2Hepatoblastoma (HP:0002884)5.05984756
3Bilateral microphthalmos (HP:0007633)4.53681684
4Premature rupture of membranes (HP:0001788)4.49837583
5Vascular tortuosity (HP:0004948)4.39710441
6Multiple enchondromatosis (HP:0005701)4.02677522
7Slender build (HP:0001533)3.79724808
8Abnormal cartilage morphology (HP:0002763)3.74876777
9Arterial tortuosity (HP:0005116)3.72074566
10Abnormality of the intrinsic pathway (HP:0010989)3.62976131
11Increased connective tissue (HP:0009025)3.62027465
12Hypochromic microcytic anemia (HP:0004840)3.46784324
13Peritonitis (HP:0002586)3.41833368
14Nemaline bodies (HP:0003798)3.34909791
15Hyperinsulinemic hypoglycemia (HP:0000825)3.28646540
16Round ear (HP:0100830)3.27310947
17Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.26186938
18Muscle fiber inclusion bodies (HP:0100299)3.20300732
19Mildly elevated creatine phosphokinase (HP:0008180)3.07760497
20Spondylolisthesis (HP:0003302)3.05936248
21Neonatal short-limb short stature (HP:0008921)2.91896256
22Cervical subluxation (HP:0003308)2.90142282
23Aortic regurgitation (HP:0001659)2.76365884
24Bowel diverticulosis (HP:0005222)2.76002166
25Ankle contracture (HP:0006466)2.74802327
26Ulnar deviation of the wrist (HP:0003049)2.74344040
27Rib fusion (HP:0000902)2.70623858
28Hand muscle atrophy (HP:0009130)2.61469909
29Fused cervical vertebrae (HP:0002949)2.58783187
30Abnormality of dentin (HP:0010299)2.55953756
31Testicular atrophy (HP:0000029)2.55059726
32Mitral regurgitation (HP:0001653)2.54548939
33Overgrowth (HP:0001548)2.53659356
34Joint stiffness (HP:0001387)2.53488805
35Mitral valve prolapse (HP:0001634)2.52374118
36Joint laxity (HP:0001388)2.50912857
37Blue sclerae (HP:0000592)2.49752821
38Broad metatarsal (HP:0001783)2.48229707
39Elbow flexion contracture (HP:0002987)2.46318299
40Hypoplastic ischia (HP:0003175)2.43032323
41Abnormality of the pubic bones (HP:0003172)2.41896403
42Atrophic scars (HP:0001075)2.41063239
43Osteolytic defects of the hand bones (HP:0009699)2.40773571
44Osteolytic defects of the phalanges of the hand (HP:0009771)2.40773571
45Flat capital femoral epiphysis (HP:0003370)2.38926896
46Skin nodule (HP:0200036)2.37688898
47Abnormality of the lower motor neuron (HP:0002366)2.37461906
48Soft skin (HP:0000977)2.36347657
49Biconcave vertebral bodies (HP:0004586)2.32999323
50Nonimmune hydrops fetalis (HP:0001790)2.31004101
51Generalized amyotrophy (HP:0003700)2.30147615
52Distal lower limb muscle weakness (HP:0009053)2.29848837
53Aortic dissection (HP:0002647)2.29739722
54Wrist flexion contracture (HP:0001239)2.29219125
55Trismus (HP:0000211)2.27754562
56Vertebral compression fractures (HP:0002953)2.27411992
57Osteoarthritis (HP:0002758)2.26169634
58Abnormality of the ischium (HP:0003174)2.23773109
59Reduced antithrombin III activity (HP:0001976)2.23271757
60Upper limb amyotrophy (HP:0009129)2.23238999
61Distal upper limb amyotrophy (HP:0007149)2.23238999
62Wide anterior fontanel (HP:0000260)2.22980783
63Asymmetric septal hypertrophy (HP:0001670)2.22483075
64Lymphangioma (HP:0100764)2.20451819
65Hyperextensible skin (HP:0000974)2.19723093
66Infantile muscular hypotonia (HP:0008947)2.19206811
67Deformed tarsal bones (HP:0008119)2.19057754
68Mitral stenosis (HP:0001718)2.19030397
69Aortic valve stenosis (HP:0001650)2.18966182
70Increased variability in muscle fiber diameter (HP:0003557)2.18714233
71Aplasia/Hypoplasia of the scapulae (HP:0006713)2.18476768
72Hypoplastic scapulae (HP:0000882)2.18476768
73Short 5th finger (HP:0009237)2.17008073
74Ovoid vertebral bodies (HP:0003300)2.16891286
75Mild short stature (HP:0003502)2.15046016
76Exercise-induced myalgia (HP:0003738)2.13817462
77Gout (HP:0001997)2.12809372
78Type 1 muscle fiber predominance (HP:0003803)2.12498069
79Calcaneovalgus deformity (HP:0001848)2.12192112
80Thoracolumbar scoliosis (HP:0002944)2.11290440
81Ectopia lentis (HP:0001083)2.10901909
82Wormian bones (HP:0002645)2.07426797
83Abnormality of the acetabulum (HP:0003170)2.07158788
84Follicular hyperkeratosis (HP:0007502)2.06583064
85Mesomelia (HP:0003027)2.05826220
86Distal arthrogryposis (HP:0005684)2.04693545
87Hypoventilation (HP:0002791)2.03303696
88Achilles tendon contracture (HP:0001771)2.01826301
89Flat acetabular roof (HP:0003180)2.01767055
90Periauricular skin pits (HP:0100277)2.00931903
91Preauricular pit (HP:0004467)2.00931903
92Aortic aneurysm (HP:0004942)2.00100000
93Hypoplasia of the fovea (HP:0007750)1.99840304
94Aplasia/Hypoplasia of the fovea (HP:0008060)1.99840304
95Abnormality of the distal phalanges of the toes (HP:0010182)1.99748835
96Bladder diverticulum (HP:0000015)1.99688242
97Ragged-red muscle fibers (HP:0003200)1.99171189
98Ulnar bowing (HP:0003031)1.99156022
99Redundant skin (HP:0001582)1.99089830
100Short humerus (HP:0005792)1.98805687
101Partial duplication of the phalanx of hand (HP:0009999)1.98593965
102Spinal rigidity (HP:0003306)1.97048743
103Genu recurvatum (HP:0002816)1.97018121
104Aneurysm (HP:0002617)1.96692630
105Limb-girdle muscle weakness (HP:0003325)1.96021888
106Cardiovascular calcification (HP:0011915)1.95711043
107Muscle fiber splitting (HP:0003555)1.95340423
108Shallow orbits (HP:0000586)1.94544202
109Beaking of vertebral bodies (HP:0004568)1.94490478
110Abnormality of the Achilles tendon (HP:0005109)1.94410310
111Coronal craniosynostosis (HP:0004440)1.94040762
112Hyperglycinuria (HP:0003108)1.92324940
113Difficulty running (HP:0009046)1.92039959
114Glossoptosis (HP:0000162)1.90475206
115Neck muscle weakness (HP:0000467)1.89168019
116Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.88295925
117Platyspondyly (HP:0000926)1.87127564
118Cerebral aneurysm (HP:0004944)1.87036742
119Hyporeflexia of lower limbs (HP:0002600)1.86974962
120Camptodactyly of toe (HP:0001836)1.86892052
121Epiphyseal dysplasia (HP:0002656)1.86626275
122Partial duplication of thumb phalanx (HP:0009944)1.86585099
123Aplasia/hypoplasia of the humerus (HP:0006507)1.85077561
124Ketoacidosis (HP:0001993)1.84066807
125Nephroblastoma (Wilms tumor) (HP:0002667)1.83518891
126Ependymoma (HP:0002888)1.82765646
127Broad ribs (HP:0000885)1.82329809
128Abnormality of skeletal muscle fiber size (HP:0012084)1.82128804
129Distal lower limb amyotrophy (HP:0008944)1.80654807
130Abnormality of skull ossification (HP:0002703)1.80462518
131Short nail (HP:0001799)1.79727963
132Embryonal renal neoplasm (HP:0011794)1.79564853
133Dilatation of the ascending aorta (HP:0005111)1.78765449
134Coxa vara (HP:0002812)1.78554726
135Delayed closure of the anterior fontanelle (HP:0001476)1.76439888
136Hip contracture (HP:0003273)1.76203600
137Absent frontal sinuses (HP:0002688)1.76116664
138Abnormality of the distal phalanx of the thumb (HP:0009617)1.76050470
139Hypoplasia of the iris (HP:0007676)1.75819331
140Thin bony cortex (HP:0002753)1.74674639
141Scapular winging (HP:0003691)1.74335419
142Shawl scrotum (HP:0000049)1.74312607
143Malnutrition (HP:0004395)1.74259498
144Fragile skin (HP:0001030)1.73884514
145Breech presentation (HP:0001623)1.73748719
146Centrally nucleated skeletal muscle fibers (HP:0003687)1.73232236
147Venous abnormality (HP:0002624)1.73172873
148Cupped ribs (HP:0000887)1.72720993
149Abnormal delivery (HP:0001787)1.71773797
150Abnormality of the calf musculature (HP:0001430)1.71763267
151Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.71667497
152Metaphyseal cupping (HP:0003021)1.71646066
153Delayed cranial suture closure (HP:0000270)1.71302388
154Abnormality of the musculature of the hand (HP:0001421)1.69960019
155Progressive muscle weakness (HP:0003323)1.69938956
156Limited hip movement (HP:0008800)1.67587238
157Emphysema (HP:0002097)1.67515136

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN16.70671282
2CDK125.64402227
3GRK53.55583413
4TGFBR22.96259702
5BCKDK2.88213871
6TESK12.81549858
7NEK92.73537346
8LIMK12.58022938
9TRIB32.57852784
10GRK62.30969736
11SIK12.27478255
12DDR22.24063278
13GRK12.20428522
14MAPK72.04317690
15CSF1R2.03164458
16ADRBK21.99291511
17LATS11.83060700
18MOS1.79441880
19WNK11.68078497
20PDGFRA1.63225741
21CDC42BPA1.62069950
22PRKG21.58450125
23GRK71.55352111
24RIPK11.49478543
25TYRO31.43960575
26AKT31.42325876
27PKN21.42152823
28ABL21.41510945
29STK101.40381887
30MATK1.38555029
31LATS21.37325981
32SCYL21.34357121
33ARAF1.26121972
34NTRK11.21909238
35TTN1.16462372
36MAP3K61.16145150
37CAMK41.14533180
38PAK41.14105572
39PTK21.13246766
40HIPK21.10461995
41STK381.09147131
42KIT1.06029035
43DAPK31.05836688
44EPHA31.03356256
45PHKG21.02455276
46PHKG11.02455276
47INSRR1.01863627
48FGFR31.00666474
49ROCK11.00665347
50TTK1.00624911
51MAP3K31.00089724
52FLT30.99617916
53ADRBK10.94789196
54TBK10.93845995
55MAP3K70.92927031
56PAK20.91958644
57PRPF4B0.91318122
58MARK20.91061079
59ROCK20.90006515
60PIK3CG0.89960160
61STK38L0.89222416
62EPHB10.89185998
63MTOR0.88029226
64MAP3K130.86539133
65MAP2K20.81159190
66IRAK30.80546704
67EPHA20.80426790
68MUSK0.80021450
69BMX0.79672712
70RPS6KA20.78508830
71PAK60.78493733
72MAPKAPK30.78216533
73CDK70.76768511
74CAMK2G0.76370891
75PAK30.75627724
76MAPK120.75546338
77MET0.69645205
78PTK60.68044126
79MAP3K100.67965078
80TYK20.67866340
81PTK2B0.65463136
82EPHB20.61803299
83JAK10.60953917
84ICK0.59870688
85FRK0.58492546
86CAMK1D0.58090239
87PAK10.57435258
88CSK0.56874663
89MAPK40.56600066
90LMTK20.55952204
91MAP3K10.55135790
92STK30.54452142
93TAOK20.54251150
94KSR20.53067360
95IGF1R0.52911872
96MYLK0.52599834
97ERBB40.51279879
98PRKD20.49312286
99PDK20.48585242
100MAP2K40.48154768
101EEF2K0.47904705
102MAP2K60.47313514
103PIM20.45077025
104ZAP700.44766328
105FER0.44583090
106MAP3K80.43850381
107STK40.43357061
108TIE10.43119154
109NME20.43082495
110PIK3CA0.41749498
111LRRK20.41521233
112PDPK10.41333044
113AKT20.41280774
114MAP3K120.40337281
115MAP2K30.38891530
116RPS6KL10.38747806
117RPS6KC10.38747806
118JAK30.38193557
119MAPKAPK20.38173710
120DYRK1B0.36545073
121PDGFRB0.35712175
122ILK0.33912982
123GSK3A0.33598286
124CAMK2D0.33502341
125DMPK0.33411130
126EIF2AK20.33113610
127MAP2K10.32850046
128PRKCI0.32137680
129BRAF0.31720696
130RPS6KB20.31718626
131CAMK10.31510601
132INSR0.30373207
133CAMK2B0.29665626
134TGFBR10.29249649
135CDK80.29127708
136PRKAA10.28756261
137PRKD10.28343076
138PDK30.28169994
139PDK40.28169994
140CHEK20.28165969
141IKBKB0.27737581
142OBSCN0.27512844
143MAPK10.26580200
144TAOK30.26536247
145PRKD30.26016497
146CHUK0.26014321
147ERBB20.25929167
148TAOK10.25542724
149FGFR40.23895524
150TRPM70.22704770

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.80870947
2Protein digestion and absorption_Homo sapiens_hsa049743.32271742
3Vitamin B6 metabolism_Homo sapiens_hsa007502.97470988
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.61497393
5Fructose and mannose metabolism_Homo sapiens_hsa000512.41367995
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.32972569
7Galactose metabolism_Homo sapiens_hsa000522.29665069
8Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.21120274
9Fat digestion and absorption_Homo sapiens_hsa049752.05680560
10Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.04928909
11Arachidonic acid metabolism_Homo sapiens_hsa005901.99757233
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.95649051
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.93599485
14ECM-receptor interaction_Homo sapiens_hsa045121.88531725
15Tryptophan metabolism_Homo sapiens_hsa003801.80290469
16Folate biosynthesis_Homo sapiens_hsa007901.74404705
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.69736634
18Other glycan degradation_Homo sapiens_hsa005111.61327364
19Linoleic acid metabolism_Homo sapiens_hsa005911.59544040
20Chemical carcinogenesis_Homo sapiens_hsa052041.57031749
21Pancreatic secretion_Homo sapiens_hsa049721.55821584
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.48031648
23Fatty acid degradation_Homo sapiens_hsa000711.46221675
24Complement and coagulation cascades_Homo sapiens_hsa046101.42568202
25Starch and sucrose metabolism_Homo sapiens_hsa005001.42022102
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.41893636
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.39240414
28Prion diseases_Homo sapiens_hsa050201.38798861
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.38162822
30Propanoate metabolism_Homo sapiens_hsa006401.34999271
31Protein export_Homo sapiens_hsa030601.33194064
32PPAR signaling pathway_Homo sapiens_hsa033201.31140233
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20956807
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.20826831
35Focal adhesion_Homo sapiens_hsa045101.19879223
36Glycerolipid metabolism_Homo sapiens_hsa005611.16964216
37Vascular smooth muscle contraction_Homo sapiens_hsa042701.13709321
38Sulfur metabolism_Homo sapiens_hsa009201.11225612
39Melanoma_Homo sapiens_hsa052181.08935402
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08736025
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06587925
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04354493
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04222225
44Selenocompound metabolism_Homo sapiens_hsa004501.03895122
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99721588
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98758695
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98504624
48Pertussis_Homo sapiens_hsa051330.98493885
49mTOR signaling pathway_Homo sapiens_hsa041500.98165575
50Fatty acid elongation_Homo sapiens_hsa000620.98090176
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94991575
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92189612
53Bladder cancer_Homo sapiens_hsa052190.89644322
54Insulin resistance_Homo sapiens_hsa049310.88568041
55Proteoglycans in cancer_Homo sapiens_hsa052050.88352885
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88157088
57Fatty acid metabolism_Homo sapiens_hsa012120.88020225
58Renin-angiotensin system_Homo sapiens_hsa046140.87901475
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87598552
60Thyroid cancer_Homo sapiens_hsa052160.86469742
61Carbon metabolism_Homo sapiens_hsa012000.86397932
62Pentose phosphate pathway_Homo sapiens_hsa000300.85735313
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85408986
64Sulfur relay system_Homo sapiens_hsa041220.84856066
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.84364847
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.83246602
67Phenylalanine metabolism_Homo sapiens_hsa003600.82628324
68Arginine and proline metabolism_Homo sapiens_hsa003300.81751717
69Basal cell carcinoma_Homo sapiens_hsa052170.79983227
70Adherens junction_Homo sapiens_hsa045200.79227164
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77716472
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.77159502
73Vibrio cholerae infection_Homo sapiens_hsa051100.76861310
74Caffeine metabolism_Homo sapiens_hsa002320.74623671
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74090230
76Platelet activation_Homo sapiens_hsa046110.73829255
77PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72485444
78Tyrosine metabolism_Homo sapiens_hsa003500.71279693
79Gap junction_Homo sapiens_hsa045400.71128166
80Dilated cardiomyopathy_Homo sapiens_hsa054140.70571421
81Melanogenesis_Homo sapiens_hsa049160.69829805
82Lysine degradation_Homo sapiens_hsa003100.68681065
83Vitamin digestion and absorption_Homo sapiens_hsa049770.68513632
84AMPK signaling pathway_Homo sapiens_hsa041520.68169574
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68146501
86Ovarian steroidogenesis_Homo sapiens_hsa049130.67213313
87Biosynthesis of amino acids_Homo sapiens_hsa012300.66855573
88Arginine biosynthesis_Homo sapiens_hsa002200.66818569
89Phagosome_Homo sapiens_hsa041450.65808537
90TNF signaling pathway_Homo sapiens_hsa046680.65578569
91Glioma_Homo sapiens_hsa052140.65366699
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64329767
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62916396
94Peroxisome_Homo sapiens_hsa041460.62846193
95Hippo signaling pathway_Homo sapiens_hsa043900.61675674
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.61401179
97Insulin signaling pathway_Homo sapiens_hsa049100.61389354
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60919758
99Chronic myeloid leukemia_Homo sapiens_hsa052200.60629970
100beta-Alanine metabolism_Homo sapiens_hsa004100.60441549
101Shigellosis_Homo sapiens_hsa051310.58943952
102Endocytosis_Homo sapiens_hsa041440.58345088
103Rap1 signaling pathway_Homo sapiens_hsa040150.57680393
104Salmonella infection_Homo sapiens_hsa051320.56644682
105TGF-beta signaling pathway_Homo sapiens_hsa043500.56468110
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.55225535
107Nitrogen metabolism_Homo sapiens_hsa009100.54875567
108GnRH signaling pathway_Homo sapiens_hsa049120.54634577
109Glucagon signaling pathway_Homo sapiens_hsa049220.54507775
110Toxoplasmosis_Homo sapiens_hsa051450.54206992
111One carbon pool by folate_Homo sapiens_hsa006700.52851560
112Oxytocin signaling pathway_Homo sapiens_hsa049210.52386826
113Pyruvate metabolism_Homo sapiens_hsa006200.50382723
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.50355699
115Lysosome_Homo sapiens_hsa041420.49976453
116Tight junction_Homo sapiens_hsa045300.48692044
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47092394
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.46849096
119Pathways in cancer_Homo sapiens_hsa052000.46842687
120Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46825786
121Prostate cancer_Homo sapiens_hsa052150.46645893
122N-Glycan biosynthesis_Homo sapiens_hsa005100.46416646
123Pancreatic cancer_Homo sapiens_hsa052120.45746507
124Hedgehog signaling pathway_Homo sapiens_hsa043400.45352059
125Axon guidance_Homo sapiens_hsa043600.45347538
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44899125
127Malaria_Homo sapiens_hsa051440.44866269
128Notch signaling pathway_Homo sapiens_hsa043300.44439507
129Cyanoamino acid metabolism_Homo sapiens_hsa004600.42474635
130Renin secretion_Homo sapiens_hsa049240.42400504
131Amoebiasis_Homo sapiens_hsa051460.42028621
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41866991
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41613726
134Bile secretion_Homo sapiens_hsa049760.41480383
135Ras signaling pathway_Homo sapiens_hsa040140.41386342
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41102821
137Retinol metabolism_Homo sapiens_hsa008300.41018547
138Glutathione metabolism_Homo sapiens_hsa004800.39765372
139Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39407240
140Calcium signaling pathway_Homo sapiens_hsa040200.39069206
141MAPK signaling pathway_Homo sapiens_hsa040100.38750571
142Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38267974
143MicroRNAs in cancer_Homo sapiens_hsa052060.37939874
144Small cell lung cancer_Homo sapiens_hsa052220.37471574
145Renal cell carcinoma_Homo sapiens_hsa052110.36755283
146Estrogen signaling pathway_Homo sapiens_hsa049150.36666026
147Osteoclast differentiation_Homo sapiens_hsa043800.33650933
148Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32543861

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