COQ10B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular glucuronidation (GO:0052695)4.54053426
2protein prenylation (GO:0018342)4.44287848
3prenylation (GO:0097354)4.44287848
4glucuronate metabolic process (GO:0019585)4.29449542
5uronic acid metabolic process (GO:0006063)4.29449542
6regulation of T cell receptor signaling pathway (GO:0050856)4.15676773
7eosinophil chemotaxis (GO:0048245)4.00842996
8negative regulation of T cell receptor signaling pathway (GO:0050860)3.91502235
9DNA deamination (GO:0045006)3.81585584
10L-fucose catabolic process (GO:0042355)3.80650474
11fucose catabolic process (GO:0019317)3.80650474
12L-fucose metabolic process (GO:0042354)3.80650474
13regulation of chronic inflammatory response (GO:0002676)3.71263450
14organelle membrane fusion (GO:0090174)3.71135144
15negative regulation of lipid storage (GO:0010888)3.63756184
16L-phenylalanine catabolic process (GO:0006559)3.60262694
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.60262694
18proteasome assembly (GO:0043248)3.60217705
19L-phenylalanine metabolic process (GO:0006558)3.59372062
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.59372062
21eosinophil migration (GO:0072677)3.57618613
22positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.55433057
23negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.53837634
24regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.52403356
25regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.49818799
26aromatic amino acid family catabolic process (GO:0009074)3.43282897
27tolerance induction (GO:0002507)3.36903603
28protein K11-linked deubiquitination (GO:0035871)3.33362672
29negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.25410758
30preassembly of GPI anchor in ER membrane (GO:0016254)3.23191415
31indolalkylamine catabolic process (GO:0046218)3.18056382
32tryptophan catabolic process (GO:0006569)3.18056382
33indole-containing compound catabolic process (GO:0042436)3.18056382
34magnesium ion transport (GO:0015693)3.15799996
35triglyceride homeostasis (GO:0070328)3.13569291
36acylglycerol homeostasis (GO:0055090)3.13569291
37cullin deneddylation (GO:0010388)3.12152354
38tryptophan metabolic process (GO:0006568)3.09761262
39peptidyl-glutamic acid carboxylation (GO:0017187)3.09513308
40protein carboxylation (GO:0018214)3.09513308
41protein deneddylation (GO:0000338)3.09238728
42fibrinolysis (GO:0042730)3.06665737
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.02300437
44positive regulation of p38MAPK cascade (GO:1900745)3.00976213
45adenosine metabolic process (GO:0046085)2.97225680
46response to nitrosative stress (GO:0051409)2.96335616
47positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.91166401
48regulation of activation of Janus kinase activity (GO:0010533)2.88631308
49positive regulation of mitotic sister chromatid separation (GO:1901970)2.88226173
50positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.88226173
51positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.88226173
52negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.88054491
53negative regulation of fibrinolysis (GO:0051918)2.83822439
54regulation of plasminogen activation (GO:0010755)2.82757890
55triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.81963473
56regulation of fibrinolysis (GO:0051917)2.81106572
57drug catabolic process (GO:0042737)2.80777579
58autophagic vacuole fusion (GO:0000046)2.80665831
59bile acid biosynthetic process (GO:0006699)2.80488350
60negative regulation of protein autophosphorylation (GO:0031953)2.79934069
61cytidine deamination (GO:0009972)2.79595562
62cytidine metabolic process (GO:0046087)2.79595562
63cytidine catabolic process (GO:0006216)2.79595562
64flavonoid metabolic process (GO:0009812)2.79401488
65regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.79040089
66xenobiotic catabolic process (GO:0042178)2.78243070
67urate metabolic process (GO:0046415)2.77273290
68positive regulation of lipoprotein lipase activity (GO:0051006)2.76726802
69positive regulation of triglyceride lipase activity (GO:0061365)2.76726802
70negative regulation of lipase activity (GO:0060192)2.76214618
71amino-acid betaine metabolic process (GO:0006577)2.76110297
72regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.73650231
73regulation of triglyceride catabolic process (GO:0010896)2.71904957
74positive regulation of defense response to virus by host (GO:0002230)2.70789123
75regulation of B cell apoptotic process (GO:0002902)2.69843962
76wound healing, spreading of epidermal cells (GO:0035313)2.68870353
77regulation of fever generation (GO:0031620)2.67644562
78cysteine metabolic process (GO:0006534)2.67151923
79desmosome organization (GO:0002934)2.67038868
80mannosylation (GO:0097502)2.66036023
81positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.65294433
82protein neddylation (GO:0045116)2.65292409
83regulation of cytokine secretion involved in immune response (GO:0002739)2.64874717
84positive regulation of interleukin-1 beta secretion (GO:0050718)2.64613272
85positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.63419143
86complement activation, alternative pathway (GO:0006957)2.62796071
87gland morphogenesis (GO:0022612)2.62295658
88high-density lipoprotein particle remodeling (GO:0034375)2.61740577
89urea cycle (GO:0000050)2.61733990
90urea metabolic process (GO:0019627)2.61733990
91RNA destabilization (GO:0050779)2.61596436
92regulation of protein activation cascade (GO:2000257)2.60894969
93kynurenine metabolic process (GO:0070189)2.60048424
94epoxygenase P450 pathway (GO:0019373)2.59610959
95positive regulation of hemostasis (GO:1900048)2.59608708
96positive regulation of blood coagulation (GO:0030194)2.59608708
97aldehyde catabolic process (GO:0046185)2.59529175
98regulation of heterotypic cell-cell adhesion (GO:0034114)2.57515481
99positive regulation of calcium ion import (GO:0090280)2.56450154
100regulation of regulatory T cell differentiation (GO:0045589)2.55849388
101regulation of metalloenzyme activity (GO:0048552)2.54837630
102regulation of sequestering of triglyceride (GO:0010889)2.54284835
103interferon-gamma production (GO:0032609)2.53435791
104positive regulation of heat generation (GO:0031652)2.51179312
105plasma lipoprotein particle clearance (GO:0034381)2.51042927
106signal peptide processing (GO:0006465)2.50903221
107regulation of interleukin-1 beta secretion (GO:0050706)2.50759495
108positive regulation of extracellular matrix organization (GO:1903055)2.50740719
109ubiquinone biosynthetic process (GO:0006744)2.50698274
110regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.49809152
111positive regulation of interleukin-1 secretion (GO:0050716)2.49729713
112positive regulation of cellular amide metabolic process (GO:0034250)2.49509097
113carnitine metabolic process (GO:0009437)2.49274866
114interleukin-1-mediated signaling pathway (GO:0070498)2.48579769
115aromatic amino acid family metabolic process (GO:0009072)2.48225319
116positive regulation of coagulation (GO:0050820)2.48025415
117regulation of complement activation (GO:0030449)2.47830045
118negative regulation of coagulation (GO:0050819)2.47419031
119pyrimidine ribonucleoside catabolic process (GO:0046133)2.46897755
120phospholipid efflux (GO:0033700)2.46871296
121water-soluble vitamin biosynthetic process (GO:0042364)2.46819405
122exogenous drug catabolic process (GO:0042738)2.46706152
123platelet dense granule organization (GO:0060155)2.45681694
124regulation of memory T cell differentiation (GO:0043380)2.45602847
125acute-phase response (GO:0006953)2.45420813
126positive regulation of lipid catabolic process (GO:0050996)2.43001496
127regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.42796162
128thrombin receptor signaling pathway (GO:0070493)2.40688728
129negative regulation of mast cell activation (GO:0033004)2.40497908
130wound healing, spreading of cells (GO:0044319)2.40046162
131positive regulation of osteoclast differentiation (GO:0045672)2.39933570
132negative regulation of fatty acid biosynthetic process (GO:0045717)2.39475848
133regulation of mononuclear cell migration (GO:0071675)2.38658183
134negative regulation of membrane potential (GO:0045837)2.37866829
135cellular biogenic amine catabolic process (GO:0042402)2.37850809
136amine catabolic process (GO:0009310)2.37850809
137nitrogen cycle metabolic process (GO:0071941)2.37312230
138regulation of cholesterol esterification (GO:0010872)2.37060689
139GPI anchor metabolic process (GO:0006505)2.37028968
140CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.36691384
141T-helper cell differentiation (GO:0042093)2.36691384
142positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.36173551
143regulation of bile acid biosynthetic process (GO:0070857)2.36128647
144C-terminal protein lipidation (GO:0006501)2.36088544
145regulation of interleukin-8 secretion (GO:2000482)2.36086913
146reverse cholesterol transport (GO:0043691)2.35907801
147regulation of cholesterol homeostasis (GO:2000188)2.35763485
148nitric oxide biosynthetic process (GO:0006809)2.35660443
149regulation of lipid storage (GO:0010883)2.35409034
150tyrosine metabolic process (GO:0006570)2.35402580
151negative regulation of thymocyte apoptotic process (GO:0070244)2.34982359
152hydrogen peroxide biosynthetic process (GO:0050665)2.34795842
153vesicle fusion (GO:0006906)2.34030185
154nicotinamide nucleotide biosynthetic process (GO:0019359)2.33928531
155pyridine nucleotide biosynthetic process (GO:0019363)2.33928531
156GPI anchor biosynthetic process (GO:0006506)2.33419568
157negative regulation of blood coagulation (GO:0030195)2.33386673
158negative regulation of hemostasis (GO:1900047)2.33386673
159benzene-containing compound metabolic process (GO:0042537)2.33066340
160sulfur amino acid catabolic process (GO:0000098)2.32877254
161homocysteine metabolic process (GO:0050667)2.32649692
162very-low-density lipoprotein particle assembly (GO:0034379)2.32292391
163respiratory chain complex IV assembly (GO:0008535)2.31590597
164response to progesterone (GO:0032570)2.31567807
165regulation of cellular amino acid metabolic process (GO:0006521)2.30115849
166positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.29226614
167regulation of T cell mediated cytotoxicity (GO:0001914)2.28940267
168ER to Golgi vesicle-mediated transport (GO:0006888)2.28648269
169regulation of germinal center formation (GO:0002634)2.25436624
170positive regulation of T cell mediated cytotoxicity (GO:0001916)2.24772039
171protein complex biogenesis (GO:0070271)2.24058662
172axoneme assembly (GO:0035082)2.23674262
173alpha-beta T cell differentiation involved in immune response (GO:0002293)2.22529872
174alpha-beta T cell activation involved in immune response (GO:0002287)2.22529872
175T cell differentiation involved in immune response (GO:0002292)2.22529872
176positive regulation of prostaglandin secretion (GO:0032308)2.22268642
177ubiquinone metabolic process (GO:0006743)2.21836059
178iron-sulfur cluster assembly (GO:0016226)2.20418731
179metallo-sulfur cluster assembly (GO:0031163)2.20418731
180regulation of autophagic vacuole assembly (GO:2000785)2.18649085
181regulation of inflammatory response to antigenic stimulus (GO:0002861)2.17866328
182indolalkylamine metabolic process (GO:0006586)2.16653216
183cellular ketone body metabolic process (GO:0046950)2.16212897
184mitotic cell cycle arrest (GO:0071850)2.16111107
185intracellular pH reduction (GO:0051452)2.15197090
186positive regulation of interleukin-1 beta production (GO:0032731)2.13413990
187regulation of interleukin-1 secretion (GO:0050704)2.12977579
188response to pheromone (GO:0019236)2.12712935
189L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.12495791
190positive regulation of T-helper 1 type immune response (GO:0002827)2.10864589
191C-terminal protein amino acid modification (GO:0018410)2.10619170
192somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.10275198
193isotype switching (GO:0045190)2.10275198
194somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.10275198

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.12462399
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.08225679
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.77189242
4* RXR_22158963_ChIP-Seq_LIVER_Mouse3.96483656
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.70359087
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.64247297
7* LXR_22158963_ChIP-Seq_LIVER_Mouse3.31412963
8TRIM28_21343339_ChIP-Seq_HEK293_Human3.22948483
9* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.22799155
10VDR_22108803_ChIP-Seq_LS180_Human3.21154937
11ESR1_21235772_ChIP-Seq_MCF-7_Human3.08015822
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.95639306
13* CLOCK_20551151_ChIP-Seq_293T_Human2.90081289
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.78936397
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.68654470
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.67253989
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.56988816
18ZNF274_21170338_ChIP-Seq_K562_Hela2.50115315
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.49466080
20* GABP_17652178_ChIP-ChIP_JURKAT_Human2.47442415
21* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.42230938
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.38395222
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.29764901
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.29069375
25IRF8_22096565_ChIP-ChIP_GC-B_Human2.27940688
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.26210810
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17446030
28NOTCH1_21737748_ChIP-Seq_TLL_Human2.16662095
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.13844167
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12421502
31ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08850478
32* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.04599438
33HIF1A_21447827_ChIP-Seq_MCF-7_Human2.04502117
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.02381791
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.98594236
36* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.95861267
37IGF1R_20145208_ChIP-Seq_DFB_Human1.91340274
38* ELK1_19687146_ChIP-ChIP_HELA_Human1.91317593
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.90754265
40* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86627760
41STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.83728294
42CJUN_26792858_Chip-Seq_BT549_Human1.82667164
43GBX2_23144817_ChIP-Seq_PC3_Human1.81035636
44* VDR_23849224_ChIP-Seq_CD4+_Human1.78497183
45P300_19829295_ChIP-Seq_ESCs_Human1.73535436
46ZNF263_19887448_ChIP-Seq_K562_Human1.73304641
47SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.72988579
48SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.72988579
49SOX2_20726797_ChIP-Seq_SW620_Human1.70086855
50SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69865546
51IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.69222295
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.67879049
53NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.67753111
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66136507
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.66095042
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.65776362
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64978090
58CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.63833653
59PPAR_26484153_Chip-Seq_NCI-H1993_Human1.63254366
60* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.62702899
61NRF2_20460467_ChIP-Seq_MEFs_Mouse1.60325325
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.60325325
63ER_23166858_ChIP-Seq_MCF-7_Human1.59312578
64EST1_17652178_ChIP-ChIP_JURKAT_Human1.58786588
65CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.58459943
66FOXO3_23340844_ChIP-Seq_DLD1_Human1.58085415
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.53522809
68TAF15_26573619_Chip-Seq_HEK293_Human1.53151428
69EWS_26573619_Chip-Seq_HEK293_Human1.49973862
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.49928332
71* NFE2_27457419_Chip-Seq_LIVER_Mouse1.47906821
72BCAT_22108803_ChIP-Seq_LS180_Human1.46826788
73FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45730905
74FUS_26573619_Chip-Seq_HEK293_Human1.44521175
75* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42779724
76MYB_21317192_ChIP-Seq_ERMYB_Mouse1.41022535
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.40926422
78NANOG_19829295_ChIP-Seq_ESCs_Human1.38174665
79SOX2_19829295_ChIP-Seq_ESCs_Human1.38174665
80HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.37061125
81FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.36431971
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35607015
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.35607015
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.33655755
85TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33012644
86* SRF_21415370_ChIP-Seq_HL-1_Mouse1.31383740
87GATA4_25053715_ChIP-Seq_YYC3_Human1.29822708
88* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.29519890
89IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29063786
90JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28932893
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28007215
92CBP_20019798_ChIP-Seq_JUKART_Human1.28007215
93FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27917728
94* TP53_22573176_ChIP-Seq_HFKS_Human1.27206931
95ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26515480
96* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26495737
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25393004
98JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24637925
99CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23458314
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22974354
101* IRF8_27001747_Chip-Seq_BMDM_Mouse1.22665325
102STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20556512
103* CRX_20693478_ChIP-Seq_RETINA_Mouse1.19113319
104TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17823965
105RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17738612
106NANOG_18555785_Chip-Seq_ESCs_Mouse1.17497668
107* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17285313
108AR_20517297_ChIP-Seq_VCAP_Human1.16827484
109RUNX_20019798_ChIP-Seq_JUKART_Human1.16355869
110CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16041938
111NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14646985
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14197606
113AR_25329375_ChIP-Seq_VCAP_Human1.13782712
114VDR_24787735_ChIP-Seq_THP-1_Human1.12932229
115* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12397405
116TCF4_22108803_ChIP-Seq_LS180_Human1.09243603
117* STAT3_18555785_Chip-Seq_ESCs_Mouse1.08179228
118TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07833012
119HTT_18923047_ChIP-ChIP_STHdh_Human1.07791389
120LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06628642
121* P53_22387025_ChIP-Seq_ESCs_Mouse1.06256194
122* MYB_26560356_Chip-Seq_TH2_Human1.05300689
123SALL4_22934838_ChIP-ChIP_CD34+_Human1.04980510
124* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04354407
125TP53_18474530_ChIP-ChIP_U2OS_Human1.03840569
126GATA3_26560356_Chip-Seq_TH1_Human1.03351721
127CMYC_18555785_Chip-Seq_ESCs_Mouse1.03343156
128IRF1_19129219_ChIP-ChIP_H3396_Human1.03005810
129* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02285051
130IRF8_21731497_ChIP-ChIP_J774_Mouse1.01637099
131MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01517150
132FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01168058
133EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01092195
134FOXP3_21729870_ChIP-Seq_TREG_Human1.00683120
135SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00390257
136PRDM14_20953172_ChIP-Seq_ESCs_Human0.99056487
137PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98978831
138PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98961009
139FOXH1_21741376_ChIP-Seq_EPCs_Human0.97537590
140E2F1_18555785_Chip-Seq_ESCs_Mouse0.97131560
141* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96610469
142TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95715740
143* SMAD4_21799915_ChIP-Seq_A2780_Human0.95224565
144CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94952390
145CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94543538
146GATA3_24758297_ChIP-Seq_MCF-7_Human0.93452109
147FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.91711404
148GATA1_22025678_ChIP-Seq_K562_Human0.91533557
149TP63_23658742_ChIP-Seq_EP156T_Human0.91213581
150BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90705969
151ATF3_27146783_Chip-Seq_COLON_Human0.88970286
152* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.86759799
153BRD4_25478319_ChIP-Seq_HGPS_Human0.85692256
154HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85621370
155* EZH2_27294783_Chip-Seq_NPCs_Mouse0.85402307
156P63_26484246_Chip-Seq_KERATINOCYTES_Human0.83602300
157* FLI1_27457419_Chip-Seq_LIVER_Mouse0.82659701
158GATA3_26560356_Chip-Seq_TH2_Human0.81550668
159KAP1_22055183_ChIP-Seq_ESCs_Mouse0.80644516
160PIAS1_25552417_ChIP-Seq_VCAP_Human0.79788230
161CDX2_20551321_ChIP-Seq_CACO-2_Human0.78452564
162UBF1/2_26484160_Chip-Seq_HMECs_Human0.76995652
163SOX2_27498859_Chip-Seq_STOMACH_Mouse0.76496019
164RXR_22108803_ChIP-Seq_LS180_Human0.76044480
165CDX2_22108803_ChIP-Seq_LS180_Human0.74886935
166SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.74691432
167* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.72488785
168POU3F2_20337985_ChIP-ChIP_501MEL_Human0.72213286
169AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.70146772
170* ELK1_22589737_ChIP-Seq_MCF10A_Human0.70034942
171AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.69933075
172* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.69636796

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.51344761
2MP0005360_urolithiasis3.49834511
3MP0005085_abnormal_gallbladder_physiolo3.48794689
4MP0003724_increased_susceptibility_to3.25418062
5MP0008875_abnormal_xenobiotic_pharmacok3.08471806
6MP0006082_CNS_inflammation3.00479905
7MP0005365_abnormal_bile_salt2.95057133
8MP0002876_abnormal_thyroid_physiology2.73617690
9MP0002138_abnormal_hepatobiliary_system2.64030645
10MP0003436_decreased_susceptibility_to2.40305493
11MP0003195_calcinosis2.32842544
12MP0002837_dystrophic_cardiac_calcinosis2.27659590
13MP0000685_abnormal_immune_system2.17161495
14MP0003303_peritoneal_inflammation2.16342896
15MP0002254_reproductive_system_inflammat2.09674898
16MP0006054_spinal_hemorrhage2.04980640
17MP0009697_abnormal_copulation2.04612858
18MP0005451_abnormal_body_composition1.99883982
19MP0004947_skin_inflammation1.98025888
20MP0002877_abnormal_melanocyte_morpholog1.94843560
21MP0003252_abnormal_bile_duct1.86168303
22MP0009785_altered_susceptibility_to1.84604677
23MP0005075_abnormal_melanosome_morpholog1.81657505
24MP0005275_abnormal_skin_tensile1.78608143
25MP0002166_altered_tumor_susceptibility1.77884951
26MP0009764_decreased_sensitivity_to1.77791621
27MP0006072_abnormal_retinal_apoptosis1.77651912
28MP0003186_abnormal_redox_activity1.75384004
29MP0004019_abnormal_vitamin_homeostasis1.73968705
30MP0001533_abnormal_skeleton_physiology1.69065592
31MP0010329_abnormal_lipoprotein_level1.65304581
32MP0002060_abnormal_skin_morphology1.63159730
33MP0005379_endocrine/exocrine_gland_phen1.62603851
34MP0000569_abnormal_digit_pigmentation1.62180625
35MP0010368_abnormal_lymphatic_system1.57902090
36MP0001853_heart_inflammation1.57647625
37MP0001542_abnormal_bone_strength1.56720598
38MP0003806_abnormal_nucleotide_metabolis1.54864832
39MP0004782_abnormal_surfactant_physiolog1.54152130
40MP0003453_abnormal_keratinocyte_physiol1.49842965
41MP0003011_delayed_dark_adaptation1.48734977
42MP0003191_abnormal_cellular_cholesterol1.47625285
43MP0002933_joint_inflammation1.47171229
44MP0008877_abnormal_DNA_methylation1.45068067
45MP0005000_abnormal_immune_tolerance1.42195201
46MP0010386_abnormal_urinary_bladder1.41414036
47MP0003941_abnormal_skin_development1.40801319
48MP0001501_abnormal_sleep_pattern1.39318488
49MP0005332_abnormal_amino_acid1.38852440
50MP0001835_abnormal_antigen_presentation1.37175412
51MP0000609_abnormal_liver_physiology1.36662704
52MP0005253_abnormal_eye_physiology1.34992416
53MP0002693_abnormal_pancreas_physiology1.33393616
54MP0003705_abnormal_hypodermis_morpholog1.33311120
55MP0001666_abnormal_nutrient_absorption1.32930441
56MP0002420_abnormal_adaptive_immunity1.32854379
57MP0001819_abnormal_immune_cell1.31432303
58MP0005084_abnormal_gallbladder_morpholo1.31293572
59MP0002277_abnormal_respiratory_mucosa1.31020936
60MP0002148_abnormal_hypersensitivity_rea1.30634319
61MP0005389_reproductive_system_phenotype1.30227393
62MP0008995_early_reproductive_senescence1.29595426
63MP0002419_abnormal_innate_immunity1.28957722
64MP0002006_tumorigenesis1.28610850
65MP0005408_hypopigmentation1.28293209
66MP0004510_myositis1.26775411
67MP0003566_abnormal_cell_adhesion1.25459680
68MP0000372_irregular_coat_pigmentation1.24998680
69MP0002163_abnormal_gland_morphology1.24897784
70MP0002796_impaired_skin_barrier1.23204850
71MP0005390_skeleton_phenotype1.20594664
72MP0005167_abnormal_blood-brain_barrier1.19710079
73MP0005387_immune_system_phenotype1.19031049
74MP0001790_abnormal_immune_system1.19031049
75MP0008872_abnormal_physiological_respon1.18705803
76MP0005164_abnormal_response_to1.17539564
77MP0002405_respiratory_system_inflammati1.17064026
78MP0009643_abnormal_urine_homeostasis1.16761859
79MP0008438_abnormal_cutaneous_collagen1.15888457
80MP0008004_abnormal_stomach_pH1.15285172
81MP0001905_abnormal_dopamine_level1.14409737
82MP0003763_abnormal_thymus_physiology1.14046882
83MP0001243_abnormal_dermal_layer1.13866806
84MP0003448_altered_tumor_morphology1.13166372
85MP0008469_abnormal_protein_level1.12726358
86MP0001216_abnormal_epidermal_layer1.12286277
87MP0002102_abnormal_ear_morphology1.12171383
88MP0001845_abnormal_inflammatory_respons1.11317911
89MP0005645_abnormal_hypothalamus_physiol1.10846983
90MP0002009_preneoplasia1.09579967
91MP0002998_abnormal_bone_remodeling1.09332777
92MP0005670_abnormal_white_adipose1.09186610
93MP0005551_abnormal_eye_electrophysiolog1.08977222
94MP0000343_altered_response_to1.08229862
95MP0001879_abnormal_lymphatic_vessel1.07653958
96MP0010234_abnormal_vibrissa_follicle1.07245876
97MP0003646_muscle_fatigue1.06951009
98MP0000015_abnormal_ear_pigmentation1.06350133
99MP0005310_abnormal_salivary_gland1.04961603
100MP0002136_abnormal_kidney_physiology1.04841084
101MP0005646_abnormal_pituitary_gland1.04708164
102MP0005083_abnormal_biliary_tract1.04325891
103MP0000465_gastrointestinal_hemorrhage1.03220907
104MP0002118_abnormal_lipid_homeostasis1.02824429
105MP0002723_abnormal_immune_serum1.01755273
106MP0009046_muscle_twitch1.00517970
107MP0005319_abnormal_enzyme/_coenzyme0.99213103
108MP0010678_abnormal_skin_adnexa0.98111914
109MP0004484_altered_response_of0.97998266
110MP0003786_premature_aging0.97744916
111MP0003795_abnormal_bone_structure0.97703323
112MP0002452_abnormal_antigen_presenting0.97153112
113MP0009763_increased_sensitivity_to0.96915536
114MP0005174_abnormal_tail_pigmentation0.95054248
115MP0005023_abnormal_wound_healing0.95032495
116MP0005410_abnormal_fertilization0.94699849
117MP0001800_abnormal_humoral_immune0.93871746
118MP0010155_abnormal_intestine_physiology0.93599913
119MP0001873_stomach_inflammation0.93118815
120MP0000689_abnormal_spleen_morphology0.92706681
121MP0005166_decreased_susceptibility_to0.92131798
122MP0009840_abnormal_foam_cell0.91239318
123MP0002295_abnormal_pulmonary_circulatio0.91108700
124MP0005671_abnormal_response_to0.89836483
125MP0005464_abnormal_platelet_physiology0.89149940
126MP0000858_altered_metastatic_potential0.88805470
127MP0003868_abnormal_feces_composition0.88532883
128MP0004883_abnormal_blood_vessel0.88467623
129MP0000716_abnormal_immune_system0.88462235
130MP0003656_abnormal_erythrocyte_physiolo0.86946938
131MP0005025_abnormal_response_to0.86457598
132MP0003638_abnormal_response/metabolism_0.85123712
133MP0006036_abnormal_mitochondrial_physio0.85005849
134MP0005636_abnormal_mineral_homeostasis0.84997281
135MP0002090_abnormal_vision0.84695181
136MP0001851_eye_inflammation0.84246958
137MP0009333_abnormal_splenocyte_physiolog0.83955184
138MP0001191_abnormal_skin_condition0.83296913
139MP0001529_abnormal_vocalization0.83248501
140MP0002132_abnormal_respiratory_system0.82963143
141MP0010352_gastrointestinal_tract_polyps0.82757171
142MP0005647_abnormal_sex_gland0.81563206
143MP0003075_altered_response_to0.81551372
144MP0004215_abnormal_myocardial_fiber0.81507298
145MP0002909_abnormal_adrenal_gland0.81299180
146MP0001919_abnormal_reproductive_system0.81090785
147MP0000647_abnormal_sebaceous_gland0.80565219
148MP0003091_abnormal_cell_migration0.79935932
149MP0001764_abnormal_homeostasis0.79738276
150MP0009384_cardiac_valve_regurgitation0.78532251
151MP0005187_abnormal_penis_morphology0.78205425
152MP0000249_abnormal_blood_vessel0.77965138
153MP0003828_pulmonary_edema0.76936474
154MP0002896_abnormal_bone_mineralization0.76607249
155MP0002398_abnormal_bone_marrow0.76463585
156MP0001756_abnormal_urination0.75780336

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.51228930
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.32174167
3Intrahepatic cholestasis (HP:0001406)3.94475727
4Prolonged partial thromboplastin time (HP:0003645)3.93276991
5Myocardial infarction (HP:0001658)3.67372473
6Abnormality of B cell number (HP:0010975)3.60306450
7Xanthomatosis (HP:0000991)3.56931293
8B lymphocytopenia (HP:0010976)3.56567645
9Abnormality of monocarboxylic acid metabolism (HP:0010996)3.53050699
10Deep venous thrombosis (HP:0002625)3.48013927
11Retrobulbar optic neuritis (HP:0100654)3.47284164
12Optic neuritis (HP:0100653)3.47284164
13Thyroiditis (HP:0100646)3.42854645
14Orchitis (HP:0100796)3.42718876
15Methylmalonic acidemia (HP:0002912)3.29685623
16IgG deficiency (HP:0004315)3.28337894
17Hypoglycemic coma (HP:0001325)3.20848658
18Abnormality of glutamine family amino acid metabolism (HP:0010902)3.17060319
19Joint hemorrhage (HP:0005261)3.07236804
20Abnormality of the intrinsic pathway (HP:0010989)3.03583873
21Hypoproteinemia (HP:0003075)2.94878767
22Hypoalphalipoproteinemia (HP:0003233)2.91956535
23Adactyly (HP:0009776)2.91647088
24Irregular epiphyses (HP:0010582)2.86295642
25Hypothermia (HP:0002045)2.80958909
26Cupped ribs (HP:0000887)2.80193223
27Methylmalonic aciduria (HP:0012120)2.79989779
28Vacuolated lymphocytes (HP:0001922)2.79953121
29Abnormality of proline metabolism (HP:0010907)2.75434628
30Hydroxyprolinuria (HP:0003080)2.75434628
31Abnormal tarsal ossification (HP:0008369)2.73471556
32Abnormality of the common coagulation pathway (HP:0010990)2.70260037
33Abnormality of T cell number (HP:0011839)2.69330118
34Epiphyseal dysplasia (HP:0002656)2.67440582
35Alveolar cell carcinoma (HP:0006519)2.66085803
36Keratoconjunctivitis sicca (HP:0001097)2.65077202
373-Methylglutaconic aciduria (HP:0003535)2.61350065
38Progressive macrocephaly (HP:0004481)2.61242372
39Mitochondrial inheritance (HP:0001427)2.61124999
40Generalized aminoaciduria (HP:0002909)2.60661700
41Hematochezia (HP:0002573)2.60592190
42Myositis (HP:0100614)2.60065837
43Abnormality of aspartate family amino acid metabolism (HP:0010899)2.59544217
44Severe combined immunodeficiency (HP:0004430)2.59395571
45Hypolipoproteinemia (HP:0010981)2.55251295
46Abnormality of methionine metabolism (HP:0010901)2.54515000
47Aplasia/hypoplasia of the uterus (HP:0008684)2.54208165
48Vitreoretinal degeneration (HP:0000655)2.52996449
49Abnormality of purine metabolism (HP:0004352)2.52378362
50Abnormality of alanine metabolism (HP:0010916)2.51823713
51Hyperalaninemia (HP:0003348)2.51823713
52Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.51823713
53Increased CSF lactate (HP:0002490)2.51703689
54Congenital, generalized hypertrichosis (HP:0004540)2.51384458
55Congenital stationary night blindness (HP:0007642)2.50779576
56Pancreatic cysts (HP:0001737)2.49563444
57Acute necrotizing encephalopathy (HP:0006965)2.48937742
58Pancreatitis (HP:0001733)2.48666357
59Short nail (HP:0001799)2.48391865
60Autoimmune hemolytic anemia (HP:0001890)2.47231073
61T lymphocytopenia (HP:0005403)2.47033610
62Hypobetalipoproteinemia (HP:0003563)2.47000707
63Right ventricular cardiomyopathy (HP:0011663)2.43282887
64Epidermoid cyst (HP:0200040)2.40702721
65Abnormality of nucleobase metabolism (HP:0010932)2.40490224
66Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.39946275
67Vascular calcification (HP:0004934)2.39284331
68Hepatocellular necrosis (HP:0001404)2.38469087
69Decreased activity of mitochondrial respiratory chain (HP:0008972)2.36720837
70Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.36720837
71Keratoconjunctivitis (HP:0001096)2.36390381
72Fat malabsorption (HP:0002630)2.35339695
73Hyperlipoproteinemia (HP:0010980)2.35245434
74Eosinophilia (HP:0001880)2.32765227
75Large for gestational age (HP:0001520)2.32639443
76Abnormal mitochondria in muscle tissue (HP:0008316)2.32460356
77Recurrent gram-negative bacterial infections (HP:0005420)2.32173497
78Cardiovascular calcification (HP:0011915)2.32118715
79Abnormality of vitamin B metabolism (HP:0004340)2.31539734
80Hepatic necrosis (HP:0002605)2.28611577
81Renal cortical cysts (HP:0000803)2.26588473
82Aortic aneurysm (HP:0004942)2.24739415
83Vascular tortuosity (HP:0004948)2.22956457
84Abnormality of eosinophils (HP:0001879)2.22931471
85Abnormal foot bone ossification (HP:0010675)2.21979139
86Increased hepatocellular lipid droplets (HP:0006565)2.20937982
87Neoplasm of the tracheobronchial system (HP:0100552)2.20929150
88Eczematoid dermatitis (HP:0000976)2.20664070
89Premature rupture of membranes (HP:0001788)2.20392059
90Abnormality of T cells (HP:0002843)2.20340818
91Lipid accumulation in hepatocytes (HP:0006561)2.18834899
92Acute encephalopathy (HP:0006846)2.18554750
93Abnormality of T cell physiology (HP:0011840)2.17870150
94Complement deficiency (HP:0004431)2.16965731
95Abnormality of pyrimidine metabolism (HP:0004353)2.16713948
96Exertional dyspnea (HP:0002875)2.16365247
97Distal lower limb muscle weakness (HP:0009053)2.15245403
98Lactic acidosis (HP:0003128)2.14945016
99Hypoglycemic seizures (HP:0002173)2.13747206
100Nausea (HP:0002018)2.10277879
101Hyperglycemia (HP:0003074)2.09810890
102Elevated erythrocyte sedimentation rate (HP:0003565)2.09682877
103Pulmonary infiltrates (HP:0002113)2.09563471
104Anorexia (HP:0002039)2.09434743
105Hypoplasia of the fovea (HP:0007750)2.06354978
106Aplasia/Hypoplasia of the fovea (HP:0008060)2.06354978
107Arterial tortuosity (HP:0005116)2.05698386
108Spontaneous abortion (HP:0005268)2.01691345
109Increased serum lactate (HP:0002151)2.01340275
110Albinism (HP:0001022)2.00787142
111Abnormal rod and cone electroretinograms (HP:0008323)2.00257639
112Arterial thrombosis (HP:0004420)2.00058896
113Steatorrhea (HP:0002570)1.99828742
114Attenuation of retinal blood vessels (HP:0007843)1.98472248
115Abnormality of sulfur amino acid metabolism (HP:0004339)1.97844935
116Increased intramyocellular lipid droplets (HP:0012240)1.97225307
117Abnormality of the renal cortex (HP:0011035)1.96307244
118Abnormality of the vitamin B12 metabolism (HP:0004341)1.94780823
119Flat capital femoral epiphysis (HP:0003370)1.94277554
120Metaphyseal dysplasia (HP:0100255)1.94253790
121Abolished electroretinogram (ERG) (HP:0000550)1.93847988
122Thrombophlebitis (HP:0004418)1.93396185
123Mitral stenosis (HP:0001718)1.92290865
124Gangrene (HP:0100758)1.91842690
125Abnormality of complement system (HP:0005339)1.91653052
126Combined immunodeficiency (HP:0005387)1.91344757
127Ketosis (HP:0001946)1.90761524
128Increased mean platelet volume (HP:0011877)1.89992981
129Hypoplastic ischia (HP:0003175)1.89840288
130Protuberant abdomen (HP:0001538)1.88948178
131Abnormal drinking behavior (HP:0030082)1.87915841
132Polydipsia (HP:0001959)1.87915841
133Autoimmune thrombocytopenia (HP:0001973)1.86839907
134Aortic dissection (HP:0002647)1.86399148
135Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.86384105
136Palpitations (HP:0001962)1.86141185
137Abnormal cartilage morphology (HP:0002763)1.85255868
138Hyperammonemia (HP:0001987)1.84988073
139Abnormality of midbrain morphology (HP:0002418)1.84718429
140Molar tooth sign on MRI (HP:0002419)1.84718429
141Esophageal varix (HP:0002040)1.84651012
142Proximal tubulopathy (HP:0000114)1.83372285
143Abnormal delayed hypersensitivity skin test (HP:0002963)1.83215802
144Gout (HP:0001997)1.83126409
145Renal Fanconi syndrome (HP:0001994)1.83118441
146Increased purine levels (HP:0004368)1.82674724
147Hyperuricemia (HP:0002149)1.82674724
148Bilateral sensorineural hearing impairment (HP:0008619)1.82486052
149Polyneuropathy (HP:0001271)1.82063263
150Abnormality of the fovea (HP:0000493)1.81975276
151Alopecia of scalp (HP:0002293)1.81212260
152Increased IgM level (HP:0003496)1.80203862
153Tetraparesis (HP:0002273)1.80013070
154Tongue fasciculations (HP:0001308)1.79260135
155Abnormality of fatty-acid metabolism (HP:0004359)1.78891822
156Hypercholesterolemia (HP:0003124)1.78139207
157Conjunctival hamartoma (HP:0100780)1.77277110
158Menorrhagia (HP:0000132)1.77188460
159Peritonitis (HP:0002586)1.76821415
160Hyperglycinuria (HP:0003108)1.76775981
161Abnormality of macular pigmentation (HP:0008002)1.75957735
162Hypoalbuminemia (HP:0003073)1.75595182
163Abnormal albumin level (HP:0012116)1.75595182
164Conjugated hyperbilirubinemia (HP:0002908)1.75398065
165Symptomatic seizures (HP:0011145)1.75111930
166Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.74790020
167Gingival bleeding (HP:0000225)1.74784561
168Beaking of vertebral bodies (HP:0004568)1.74145646
169Joint swelling (HP:0001386)1.73436828
170Leukocytosis (HP:0001974)1.73097422
171Delayed epiphyseal ossification (HP:0002663)1.73074647
172Prostate neoplasm (HP:0100787)1.73000858
173Abnormal platelet volume (HP:0011876)1.72853681
174Pancreatic fibrosis (HP:0100732)1.72486380
175Abnormality of urine glucose concentration (HP:0011016)1.72328397
176Glycosuria (HP:0003076)1.72328397
177Stillbirth (HP:0003826)1.72305908
178Insulin-resistant diabetes mellitus (HP:0000831)1.71786601
179Ketoacidosis (HP:0001993)1.71669554
180Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.71101524
181Respiratory failure (HP:0002878)1.70602811
182Chronic sinusitis (HP:0011109)1.70548900
183Optic disc pallor (HP:0000543)1.68863808
184Posterior subcapsular cataract (HP:0007787)1.68192945
185IgM deficiency (HP:0002850)1.67790256
186Recurrent bronchitis (HP:0002837)1.67385799
187Abnormal glycosylation (HP:0012345)1.66320757
188Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.66320757
189Abnormal protein N-linked glycosylation (HP:0012347)1.66320757
190Abnormal protein glycosylation (HP:0012346)1.66320757

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK24.53337197
2MAP3K143.83417324
3MAP3K33.67991252
4IRAK33.45447879
5EIF2AK32.91313961
6MST42.66850575
7MAP4K22.51024499
8PIK3CG2.46835750
9MKNK12.46026120
10TRIM282.41280725
11NEK92.40898656
12TAOK32.40432091
13ADRBK22.34286809
14PIM22.28478736
15STK38L2.18977908
16TGFBR22.06031987
17GRK12.01147829
18IKBKB1.94198488
19LATS11.91100612
20MAPK151.84515553
21BMPR21.79559452
22ERBB41.76638521
23TBK11.68493949
24MAP2K31.60815713
25TXK1.58007256
26IKBKE1.52527906
27CHUK1.49917674
28NUAK11.47197997
29EPHA21.44281591
30SIK31.44162547
31NLK1.43641120
32TIE11.42176733
33RIPK11.41721785
34MAP2K21.39158816
35FGFR41.33861382
36FRK1.31891420
37PLK21.30136208
38JAK31.27292007
39TRPM71.26171715
40BRSK21.22339633
41TEC1.20927069
42WNK31.19127891
43MAP3K51.18597645
44ABL21.18568108
45MOS1.18489328
46PIM11.17854072
47EPHA31.17313720
48ERBB31.16206653
49CAMKK21.15342712
50JAK11.12844537
51NME21.11801599
52MELK1.11758483
53ZAK1.11717163
54BCKDK1.10798659
55BCR1.09578376
56MST1R1.08329728
57STK241.05940662
58MAPKAPK31.04359981
59CSNK1G11.04262800
60EIF2AK11.03119285
61RPS6KA41.02696786
62STK31.01880511
63BMPR1B1.01785284
64CDK91.00927503
65IRAK10.99723912
66TYK20.99483930
67SRPK10.98792501
68MAP3K130.98751793
69GRK60.96616028
70STK100.96228028
71PDK20.95154183
72FER0.94043488
73PAK30.92017334
74FGFR30.91109020
75TLK10.90788841
76ACVR1B0.89801458
77DYRK1A0.87974475
78MYLK0.87852264
79TAOK20.87578714
80EIF2AK20.85395149
81MAP3K110.82818462
82EPHB20.82271217
83MUSK0.81467409
84GSK3A0.79991214
85ARAF0.77392283
86BRAF0.77035217
87OXSR10.76744367
88ITK0.76483410
89PRKCE0.76481996
90MAP3K40.75962052
91INSRR0.73129874
92SYK0.72465939
93TAOK10.72094068
94PRKCQ0.71262501
95ADRBK10.69848361
96MAP2K10.69724751
97WNK40.68469416
98CSNK1G30.67925078
99MAP3K60.67527734
100ERN10.66889884
101STK390.65999471
102KDR0.65998596
103IRAK40.65340360
104PIK3CA0.63883175
105CSNK1G20.63694727
106TESK10.62655028
107MAP3K20.61731994
108CDK80.61308753
109VRK10.60956000
110PRKCI0.60220392
111DYRK30.59603032
112MAPK70.56614590
113MAPK40.55228844
114FLT30.55029011
115PLK30.54813265
116MAP3K120.53960322
117PHKG10.53930835
118PHKG20.53930835
119PTK2B0.53808551
120LCK0.51642505
121ABL10.51557761
122LYN0.51549573
123RIPK40.51353190
124ZAP700.51119310
125KIT0.49079825
126AKT30.47890169
127TGFBR10.46610435
128PASK0.46198649
129CSNK1A1L0.45799327
130DAPK20.45654416
131RAF10.45288564
132FGFR20.44828877
133LATS20.44659473
134JAK20.43323389
135PLK40.43261751
136SGK20.43028534
137GRK70.42374006
138IGF1R0.41527800
139MARK30.41285763
140MAPKAPK50.40551085
141PRKG20.40238620
142CSK0.39826397
143MAP3K10.39011236
144VRK20.37700006
145PRKAA20.36361377
146LIMK10.35659734
147WEE10.35134341
148PINK10.34493642
149RPS6KA50.33423659
150MAP2K70.32898033
151PRKCG0.32193836

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.47266733
2Proteasome_Homo sapiens_hsa030503.29730002
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.23565254
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.96716777
5SNARE interactions in vesicular transport_Homo sapiens_hsa041302.70445798
6Complement and coagulation cascades_Homo sapiens_hsa046102.51467316
7Asthma_Homo sapiens_hsa053102.41752484
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.40499126
9Primary immunodeficiency_Homo sapiens_hsa053402.29854635
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.21400474
11Steroid hormone biosynthesis_Homo sapiens_hsa001402.20233981
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.17050038
13Oxidative phosphorylation_Homo sapiens_hsa001902.14319415
14Chemical carcinogenesis_Homo sapiens_hsa052042.13174680
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.11365825
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.10837219
17Autoimmune thyroid disease_Homo sapiens_hsa053202.09182893
18Staphylococcus aureus infection_Homo sapiens_hsa051501.97699779
19Tryptophan metabolism_Homo sapiens_hsa003801.86484065
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.83275144
21Graft-versus-host disease_Homo sapiens_hsa053321.82836617
22Retinol metabolism_Homo sapiens_hsa008301.80985556
23Collecting duct acid secretion_Homo sapiens_hsa049661.76769429
24Fatty acid degradation_Homo sapiens_hsa000711.75406696
25Starch and sucrose metabolism_Homo sapiens_hsa005001.75305907
26Arginine biosynthesis_Homo sapiens_hsa002201.73915528
27Caffeine metabolism_Homo sapiens_hsa002321.69222439
28TNF signaling pathway_Homo sapiens_hsa046681.59854299
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.57800259
30Regulation of autophagy_Homo sapiens_hsa041401.57720176
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.57652488
32PPAR signaling pathway_Homo sapiens_hsa033201.57381008
33Steroid biosynthesis_Homo sapiens_hsa001001.57369048
34Histidine metabolism_Homo sapiens_hsa003401.56159443
35Sulfur metabolism_Homo sapiens_hsa009201.56107970
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.55531705
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.55326964
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54582689
39Rheumatoid arthritis_Homo sapiens_hsa053231.51482274
40Folate biosynthesis_Homo sapiens_hsa007901.51410337
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.50839000
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.50442467
43Legionellosis_Homo sapiens_hsa051341.45770904
44Leishmaniasis_Homo sapiens_hsa051401.43460727
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.42792700
46Phototransduction_Homo sapiens_hsa047441.42415214
47Basal transcription factors_Homo sapiens_hsa030221.37571945
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36851979
49Drug metabolism - other enzymes_Homo sapiens_hsa009831.34981351
50Parkinsons disease_Homo sapiens_hsa050121.34459994
51Phenylalanine metabolism_Homo sapiens_hsa003601.34026901
52Circadian rhythm_Homo sapiens_hsa047101.32698898
53Peroxisome_Homo sapiens_hsa041461.32004967
54Nitrogen metabolism_Homo sapiens_hsa009101.31714565
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21718860
56RNA polymerase_Homo sapiens_hsa030201.20987778
57Malaria_Homo sapiens_hsa051441.19235701
58NOD-like receptor signaling pathway_Homo sapiens_hsa046211.18777002
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18574287
60beta-Alanine metabolism_Homo sapiens_hsa004101.18548571
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16349004
62Propanoate metabolism_Homo sapiens_hsa006401.14093526
63Linoleic acid metabolism_Homo sapiens_hsa005911.12163157
64Osteoclast differentiation_Homo sapiens_hsa043801.11818267
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07580315
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03913250
67RNA degradation_Homo sapiens_hsa030181.03171067
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02419227
69Ether lipid metabolism_Homo sapiens_hsa005650.99501725
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.95394395
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91651380
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91252082
73Protein export_Homo sapiens_hsa030600.89148067
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87444870
75Pertussis_Homo sapiens_hsa051330.86603846
76Butanoate metabolism_Homo sapiens_hsa006500.86233257
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86165833
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85457627
79Alzheimers disease_Homo sapiens_hsa050100.85363385
80Glutathione metabolism_Homo sapiens_hsa004800.85344943
81Selenocompound metabolism_Homo sapiens_hsa004500.85221171
82Fatty acid metabolism_Homo sapiens_hsa012120.82481070
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79252268
84African trypanosomiasis_Homo sapiens_hsa051430.75146496
85Mineral absorption_Homo sapiens_hsa049780.72601148
86Vitamin digestion and absorption_Homo sapiens_hsa049770.72576546
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70892920
88Taste transduction_Homo sapiens_hsa047420.69648576
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69514754
90T cell receptor signaling pathway_Homo sapiens_hsa046600.69158207
91Hematopoietic cell lineage_Homo sapiens_hsa046400.67744000
92Apoptosis_Homo sapiens_hsa042100.66986375
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66723211
94Tyrosine metabolism_Homo sapiens_hsa003500.66287630
95Bile secretion_Homo sapiens_hsa049760.66270172
96Lysosome_Homo sapiens_hsa041420.63595533
97Arginine and proline metabolism_Homo sapiens_hsa003300.63456411
98Measles_Homo sapiens_hsa051620.62419301
99Huntingtons disease_Homo sapiens_hsa050160.59161923
100Fatty acid elongation_Homo sapiens_hsa000620.59147755
101Influenza A_Homo sapiens_hsa051640.58459291
102p53 signaling pathway_Homo sapiens_hsa041150.58144648
103Antigen processing and presentation_Homo sapiens_hsa046120.58042201
104Sphingolipid metabolism_Homo sapiens_hsa006000.57694798
105Viral myocarditis_Homo sapiens_hsa054160.57177754
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56323205
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.56231727
108Jak-STAT signaling pathway_Homo sapiens_hsa046300.55361022
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55017165
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51869306
111Ovarian steroidogenesis_Homo sapiens_hsa049130.51668456
112Prion diseases_Homo sapiens_hsa050200.51282826
113Galactose metabolism_Homo sapiens_hsa000520.49250927
114TGF-beta signaling pathway_Homo sapiens_hsa043500.49039114
115FoxO signaling pathway_Homo sapiens_hsa040680.48985204
116Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48794609
117Toxoplasmosis_Homo sapiens_hsa051450.48293422
118Hepatitis B_Homo sapiens_hsa051610.47222078
119Insulin resistance_Homo sapiens_hsa049310.46185536
120Fat digestion and absorption_Homo sapiens_hsa049750.45660829
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43658605
122Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43169829
123ABC transporters_Homo sapiens_hsa020100.43021573
124ECM-receptor interaction_Homo sapiens_hsa045120.42289769
125Phagosome_Homo sapiens_hsa041450.41948951
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41943191
127Glycerolipid metabolism_Homo sapiens_hsa005610.41109621
128Tuberculosis_Homo sapiens_hsa051520.40713933
129One carbon pool by folate_Homo sapiens_hsa006700.39857857
130Arachidonic acid metabolism_Homo sapiens_hsa005900.39846341
131Allograft rejection_Homo sapiens_hsa053300.39355119
132Metabolic pathways_Homo sapiens_hsa011000.37637215
133Prolactin signaling pathway_Homo sapiens_hsa049170.35988552
134Non-homologous end-joining_Homo sapiens_hsa034500.34556073
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33959479
136Hepatitis C_Homo sapiens_hsa051600.32413586
137Type I diabetes mellitus_Homo sapiens_hsa049400.31941941
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31299779
139Herpes simplex infection_Homo sapiens_hsa051680.28922224

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