COQ10BP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.83233257
2neural tube formation (GO:0001841)5.80289177
3valine metabolic process (GO:0006573)5.55022910
4photoreceptor cell maintenance (GO:0045494)5.39338515
5regulation of memory T cell differentiation (GO:0043380)5.15737234
6kidney morphogenesis (GO:0060993)4.99367423
7transcription elongation from RNA polymerase III promoter (GO:0006385)4.98792048
8termination of RNA polymerase III transcription (GO:0006386)4.98792048
9rRNA catabolic process (GO:0016075)4.74401486
10nerve growth factor signaling pathway (GO:0038180)4.71600672
11water-soluble vitamin biosynthetic process (GO:0042364)4.62572873
12DNA deamination (GO:0045006)4.52686473
13smooth muscle tissue development (GO:0048745)4.39112301
14maturation of 5.8S rRNA (GO:0000460)4.33259373
15aggressive behavior (GO:0002118)4.27366515
16regulation of gene expression by genetic imprinting (GO:0006349)4.27241370
17positive regulation of vasculogenesis (GO:2001214)4.01594247
18intra-S DNA damage checkpoint (GO:0031573)3.99967143
19relaxation of smooth muscle (GO:0044557)3.92697401
20regulation of response to tumor cell (GO:0002834)3.92477973
21positive regulation of response to tumor cell (GO:0002836)3.92477973
22positive regulation of immune response to tumor cell (GO:0002839)3.92477973
23regulation of immune response to tumor cell (GO:0002837)3.92477973
24piRNA metabolic process (GO:0034587)3.82740908
25I-kappaB phosphorylation (GO:0007252)3.77141746
26coenzyme catabolic process (GO:0009109)3.65438739
27somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.60797156
28somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.60797156
29isotype switching (GO:0045190)3.60797156
30forebrain morphogenesis (GO:0048853)3.56308896
31response to X-ray (GO:0010165)3.52688692
32regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.52180697
33regulation of mitotic spindle checkpoint (GO:1903504)3.52180697
34stress granule assembly (GO:0034063)3.50732475
35serotonin receptor signaling pathway (GO:0007210)3.48879301
36detection of light stimulus involved in sensory perception (GO:0050962)3.48472311
37detection of light stimulus involved in visual perception (GO:0050908)3.48472311
38mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.44895237
39positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.44895237
40somatic diversification of immune receptors via somatic mutation (GO:0002566)3.40349162
41somatic hypermutation of immunoglobulin genes (GO:0016446)3.40349162
42regulation of establishment of cell polarity (GO:2000114)3.35100180
43cytoplasmic mRNA processing body assembly (GO:0033962)3.34602068
44negative regulation of homotypic cell-cell adhesion (GO:0034111)3.30834161
45regulation of platelet aggregation (GO:0090330)3.26005401
46negative regulation of multicellular organism growth (GO:0040015)3.21622678
47negative regulation of protein autophosphorylation (GO:0031953)3.19026585
48negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.17966326
49pseudouridine synthesis (GO:0001522)3.16941891
50thrombin receptor signaling pathway (GO:0070493)3.16092059
51establishment of protein localization to vacuole (GO:0072666)3.15162408
52protein targeting to vacuole (GO:0006623)3.15162408
53protein targeting to lysosome (GO:0006622)3.15162408
54branched-chain amino acid catabolic process (GO:0009083)3.14363285
55negative regulation of necroptotic process (GO:0060546)3.12212017
56branched-chain amino acid metabolic process (GO:0009081)3.11776810
57response to pheromone (GO:0019236)3.10923237
58rRNA modification (GO:0000154)3.08075107
59regulation of vasculogenesis (GO:2001212)3.07494121
60RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.05974975
61behavioral response to ethanol (GO:0048149)3.02057609
62regulation of MHC class I biosynthetic process (GO:0045343)3.01369006
63cellular response to ATP (GO:0071318)2.99075136
64indole-containing compound catabolic process (GO:0042436)2.90284831
65indolalkylamine catabolic process (GO:0046218)2.90284831
66tryptophan catabolic process (GO:0006569)2.90284831
67regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.89844082
68positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.89844082
69positive regulation of natural killer cell activation (GO:0032816)2.86982023
70aromatic amino acid family catabolic process (GO:0009074)2.84309784
71phosphatidylinositol acyl-chain remodeling (GO:0036149)2.84146573
72DNA methylation involved in gamete generation (GO:0043046)2.83576974
73positive regulation of T cell mediated cytotoxicity (GO:0001916)2.82501329
74centrosome duplication (GO:0051298)2.82260742
75proteasome assembly (GO:0043248)2.81395823
76positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.80088973
77regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.80088973
78protein import into peroxisome matrix (GO:0016558)2.78000521
79erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.77587857
80L-phenylalanine catabolic process (GO:0006559)2.77587857
81somatic diversification of immunoglobulins (GO:0016445)2.77419049
82RNA localization (GO:0006403)2.76855306
83positive regulation of T cell cytokine production (GO:0002726)2.75724863
84regulation of establishment or maintenance of cell polarity (GO:0032878)2.74765241
85positive regulation of prostaglandin secretion (GO:0032308)2.74537196
86embryonic epithelial tube formation (GO:0001838)2.68853704
87genetic imprinting (GO:0071514)2.66985656
88positive regulation of protein homooligomerization (GO:0032464)2.65404581
89positive regulation of mRNA catabolic process (GO:0061014)2.65157818
90nucleotide transmembrane transport (GO:1901679)2.64912522
91regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.64056220
92positive regulation of transforming growth factor beta production (GO:0071636)2.63110689
93defense response to protozoan (GO:0042832)2.60807563
94negative regulation of cation channel activity (GO:2001258)2.60273905
95regulation of gamma-delta T cell differentiation (GO:0045586)2.59729005
96regulation of DNA endoreduplication (GO:0032875)2.59637730
97tyrosine metabolic process (GO:0006570)2.58712720
98regulation of sequestering of triglyceride (GO:0010889)2.58690140
99cellular response to nerve growth factor stimulus (GO:1990090)2.58600298
100response to nerve growth factor (GO:1990089)2.58600298

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human4.62991711
2VDR_22108803_ChIP-Seq_LS180_Human3.99845963
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.07239468
4NOTCH1_21737748_ChIP-Seq_TLL_Human3.02257415
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.97432413
6ZNF274_21170338_ChIP-Seq_K562_Hela2.83725367
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.79554317
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.58845245
9EWS_26573619_Chip-Seq_HEK293_Human2.44559536
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.39929034
11FUS_26573619_Chip-Seq_HEK293_Human2.33837323
12IGF1R_20145208_ChIP-Seq_DFB_Human2.16556984
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.11155428
14TAF15_26573619_Chip-Seq_HEK293_Human2.09221052
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.01693245
16FLI1_27457419_Chip-Seq_LIVER_Mouse1.96898893
17POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95321246
18BCAT_22108803_ChIP-Seq_LS180_Human1.93310767
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91318255
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.80100228
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.78469782
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73822463
23ER_23166858_ChIP-Seq_MCF-7_Human1.65228995
24GBX2_23144817_ChIP-Seq_PC3_Human1.64469970
25HTT_18923047_ChIP-ChIP_STHdh_Human1.61893265
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.61715522
27FOXA1_25329375_ChIP-Seq_VCAP_Human1.60954041
28FOXA1_27270436_Chip-Seq_PROSTATE_Human1.60954041
29SCL_19346495_ChIP-Seq_HPC-7_Human1.57210396
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.55368295
31P300_19829295_ChIP-Seq_ESCs_Human1.55277333
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.53782355
33VDR_23849224_ChIP-Seq_CD4+_Human1.51357705
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.50039193
35CDX2_22108803_ChIP-Seq_LS180_Human1.49682356
36ESR1_15608294_ChIP-ChIP_MCF-7_Human1.46428250
37TP53_22573176_ChIP-Seq_HFKS_Human1.45257526
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45240447
39NANOG_19829295_ChIP-Seq_ESCs_Human1.43574237
40SOX2_19829295_ChIP-Seq_ESCs_Human1.43574237
41ELK1_19687146_ChIP-ChIP_HELA_Human1.40987230
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39709672
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39523920
44NANOG_20526341_ChIP-Seq_ESCs_Human1.37475793
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36832774
46EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36094719
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35448975
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.34607991
49GABP_17652178_ChIP-ChIP_JURKAT_Human1.31686983
50FOXP3_21729870_ChIP-Seq_TREG_Human1.29296759
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28209568
52CBP_20019798_ChIP-Seq_JUKART_Human1.27066358
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27066358
54PRDM14_20953172_ChIP-Seq_ESCs_Human1.27033973
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26570872
56JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.22459642
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21138035
58STAT3_23295773_ChIP-Seq_U87_Human1.20793263
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.20234194
60SALL4_22934838_ChIP-ChIP_CD34+_Human1.17468115
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15670635
62AR_20517297_ChIP-Seq_VCAP_Human1.15015895
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13594405
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11716922
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10514661
66GATA3_26560356_Chip-Seq_TH1_Human1.10301161
67TCF4_23295773_ChIP-Seq_U87_Human1.09835884
68FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09010301
69TCF4_22108803_ChIP-Seq_LS180_Human1.07423722
70IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.06050882
71GATA3_26560356_Chip-Seq_TH2_Human1.06036499
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05462696
73HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05403145
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.04377455
75ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02841738
76ETV1_20927104_ChIP-Seq_GIST48_Human1.02472428
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02057688
78SMAD4_21741376_ChIP-Seq_EPCs_Human1.00601558
79TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00116241
80EST1_17652178_ChIP-ChIP_JURKAT_Human0.98525472
81NANOG_18555785_Chip-Seq_ESCs_Mouse0.98497482
82EZH2_27294783_Chip-Seq_NPCs_Mouse0.97922398
83NCOR_22424771_ChIP-Seq_293T_Human0.97715778
84E2F7_22180533_ChIP-Seq_HELA_Human0.96468764
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96426419
86P53_21459846_ChIP-Seq_SAOS-2_Human0.95837318
87NFYB_21822215_ChIP-Seq_K562_Human0.95782222
88TAF2_19829295_ChIP-Seq_ESCs_Human0.95692578
89OCT1_27270436_Chip-Seq_PROSTATE_Human0.94565479
90MYC_18940864_ChIP-ChIP_HL60_Human0.93508531
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93260570
92CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92627120
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92226509
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92083814
95PHF8_20622853_ChIP-Seq_HELA_Human0.91507369
96TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.90546022
97EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90361679
98ETS1_20019798_ChIP-Seq_JURKAT_Human0.90317844
99VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90274631
100PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.90267238

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting5.46578913
2MP0003252_abnormal_bile_duct3.70892312
3MP0003718_maternal_effect3.00257863
4MP0008877_abnormal_DNA_methylation2.98475390
5MP0009697_abnormal_copulation2.82489551
6MP0004808_abnormal_hematopoietic_stem2.64685750
7MP0002254_reproductive_system_inflammat2.51962809
8MP0002876_abnormal_thyroid_physiology2.44052328
9MP0003011_delayed_dark_adaptation2.34879695
10MP0002138_abnormal_hepatobiliary_system2.30411825
11MP0002736_abnormal_nociception_after2.28023072
12MP0008875_abnormal_xenobiotic_pharmacok2.27902987
13MP0008058_abnormal_DNA_repair2.09695820
14MP0003300_gastrointestinal_ulcer2.08252524
15MP0005646_abnormal_pituitary_gland2.04593180
16MP0008007_abnormal_cellular_replicative1.97829878
17MP0001968_abnormal_touch/_nociception1.96466354
18MP0001764_abnormal_homeostasis1.93409137
19MP0004147_increased_porphyrin_level1.89677957
20MP0002009_preneoplasia1.89480963
21MP0001501_abnormal_sleep_pattern1.84767698
22MP0005410_abnormal_fertilization1.78782766
23MP0005551_abnormal_eye_electrophysiolog1.76098291
24MP0002837_dystrophic_cardiac_calcinosis1.74896955
25MP0006035_abnormal_mitochondrial_morpho1.73660355
26MP0004133_heterotaxia1.73278187
27MP0005253_abnormal_eye_physiology1.68097078
28MP0001986_abnormal_taste_sensitivity1.58810517
29MP0004130_abnormal_muscle_cell1.57083372
30MP0004885_abnormal_endolymph1.56914030
31MP0010386_abnormal_urinary_bladder1.53226982
32MP0002160_abnormal_reproductive_system1.51810750
33MP0002102_abnormal_ear_morphology1.48158234
34MP0000569_abnormal_digit_pigmentation1.45001961
35MP0000685_abnormal_immune_system1.44679830
36MP0002928_abnormal_bile_duct1.43745446
37MP0000371_diluted_coat_color1.38571065
38MP0006036_abnormal_mitochondrial_physio1.37128459
39MP0003121_genomic_imprinting1.36707005
40MP0001835_abnormal_antigen_presentation1.32496238
41MP0000015_abnormal_ear_pigmentation1.31842882
42MP0005645_abnormal_hypothalamus_physiol1.31347643
43MP0001188_hyperpigmentation1.27158325
44MP0008995_early_reproductive_senescence1.26496172
45MP0002166_altered_tumor_susceptibility1.21709533
46MP0009046_muscle_twitch1.21671390
47MP0006276_abnormal_autonomic_nervous1.18511236
48MP0003195_calcinosis1.18072039
49MP0001661_extended_life_span1.17940690
50MP0003786_premature_aging1.16429667
51MP0004084_abnormal_cardiac_muscle1.16236125
52MP0005389_reproductive_system_phenotype1.15080698
53MP0005395_other_phenotype1.15034339
54MP0003943_abnormal_hepatobiliary_system1.14852188
55MP0002148_abnormal_hypersensitivity_rea1.13121355
56MP0005174_abnormal_tail_pigmentation1.10747248
57MP0009765_abnormal_xenobiotic_induced1.09523273
58MP0002277_abnormal_respiratory_mucosa1.09388303
59MP0002006_tumorigenesis1.06556192
60MP0002693_abnormal_pancreas_physiology1.03477499
61MP0000372_irregular_coat_pigmentation1.02823905
62MP0002396_abnormal_hematopoietic_system1.00660329
63MP0005647_abnormal_sex_gland1.00280897
64MP0003329_amyloid_beta_deposits1.00189380
65MP0001984_abnormal_olfaction0.98801313
66MP0005332_abnormal_amino_acid0.97594019
67MP0006082_CNS_inflammation0.97200485
68MP0001944_abnormal_pancreas_morphology0.95963858
69MP0006072_abnormal_retinal_apoptosis0.93447401
70MP0005075_abnormal_melanosome_morpholog0.90037487
71MP0001324_abnormal_eye_pigmentation0.87609555
72MP0003693_abnormal_embryo_hatching0.84448371
73MP0001346_abnormal_lacrimal_gland0.82880182
74MP0006292_abnormal_olfactory_placode0.82538581
75MP0001879_abnormal_lymphatic_vessel0.82471740
76MP0002163_abnormal_gland_morphology0.82178390
77MP0008872_abnormal_physiological_respon0.81392558
78MP0003283_abnormal_digestive_organ0.73836328
79MP0001119_abnormal_female_reproductive0.73550327
80MP0001502_abnormal_circadian_rhythm0.72961590
81MP0009745_abnormal_behavioral_response0.72662826
82MP0002019_abnormal_tumor_incidence0.67298699
83MP0000604_amyloidosis0.67225124
84MP0000689_abnormal_spleen_morphology0.64893060
85MP0002733_abnormal_thermal_nociception0.64188728
86MP0005535_abnormal_body_temperature0.64089841
87MP0005195_abnormal_posterior_eye0.64064769
88MP0003806_abnormal_nucleotide_metabolis0.63126362
89MP0003633_abnormal_nervous_system0.62920154
90MP0003172_abnormal_lysosome_physiology0.62370435
91MP0010368_abnormal_lymphatic_system0.61062125
92MP0008770_decreased_survivor_rate0.60768831
93MP0000653_abnormal_sex_gland0.60461963
94MP0008775_abnormal_heart_ventricle0.59336861
95MP0002638_abnormal_pupillary_reflex0.58135115
96MP0003646_muscle_fatigue0.57404659
97MP0005379_endocrine/exocrine_gland_phen0.56978244
98MP0001664_abnormal_digestion0.56760696
99MP0002136_abnormal_kidney_physiology0.56670829
100MP0002229_neurodegeneration0.56345505

Predicted human phenotypes

RankGene SetZ-score
1Spontaneous abortion (HP:0005268)5.73111243
2Stomatitis (HP:0010280)5.12187362
3Abnormality of the renal cortex (HP:0011035)4.56877142
4Hypoplastic pelvis (HP:0008839)4.29543148
5Genetic anticipation (HP:0003743)4.10175066
6Renal cortical cysts (HP:0000803)3.89396825
7Abnormal biliary tract physiology (HP:0012439)3.85939113
8Bile duct proliferation (HP:0001408)3.85939113
9Abnormality of the renal medulla (HP:0100957)3.74452207
10Supernumerary spleens (HP:0009799)3.73750970
11Aplasia/Hypoplasia of the spleen (HP:0010451)3.66035268
12Pancreatic fibrosis (HP:0100732)3.57209318
13Pancreatic cysts (HP:0001737)3.55950274
14Hyperglycemia (HP:0003074)3.54550658
15Asplenia (HP:0001746)3.53063908
16Tubular atrophy (HP:0000092)3.42591573
17Enlarged kidneys (HP:0000105)3.42524560
18Thrombocytosis (HP:0001894)3.35147180
19Nephronophthisis (HP:0000090)3.32467960
20Abnormal drinking behavior (HP:0030082)3.31373064
21Polydipsia (HP:0001959)3.31373064
22Menstrual irregularities (HP:0000858)3.27244335
23Increased IgM level (HP:0003496)3.25646980
24Insulin-resistant diabetes mellitus (HP:0000831)3.25484433
25Abolished electroretinogram (ERG) (HP:0000550)3.22686283
26Prostate neoplasm (HP:0100787)3.05854184
27Progressive cerebellar ataxia (HP:0002073)3.01440942
28Congenital stationary night blindness (HP:0007642)2.95968197
29Abnormal biliary tract morphology (HP:0012440)2.87590100
30Abnormality of macular pigmentation (HP:0008002)2.85508576
31Hypoplastic iliac wings (HP:0002866)2.85218881
32Central scotoma (HP:0000603)2.85015234
33Abnormality of the heme biosynthetic pathway (HP:0010472)2.81953232
34Abnormality of the hepatic vasculature (HP:0006707)2.81429225
35Reduced subcutaneous adipose tissue (HP:0003758)2.80477361
36Dry hair (HP:0011359)2.75583558
37Abnormal delivery (HP:0001787)2.75392258
38Hyperglycinuria (HP:0003108)2.71659101
39Tinnitus (HP:0000360)2.70418191
40Facial shape deformation (HP:0011334)2.69361776
41Potter facies (HP:0002009)2.69361776
42Widely patent fontanelles and sutures (HP:0004492)2.68607133
43Aplasia/Hypoplasia of the fovea (HP:0008060)2.67015386
44Hypoplasia of the fovea (HP:0007750)2.67015386
45Amaurosis fugax (HP:0100576)2.66561889
46Progressive inability to walk (HP:0002505)2.65802391
47Breech presentation (HP:0001623)2.59353079
48Arterial thrombosis (HP:0004420)2.58239038
49Cystic liver disease (HP:0006706)2.56829279
50Abnormality of T cell physiology (HP:0011840)2.54790187
51Attenuation of retinal blood vessels (HP:0007843)2.52616949
52Facial diplegia (HP:0001349)2.52235505
53Severe visual impairment (HP:0001141)2.50686408
54Posterior subcapsular cataract (HP:0007787)2.50024823
55Hyperglycinemia (HP:0002154)2.49525248
56Autoimmune thrombocytopenia (HP:0001973)2.47838927
57Decreased lacrimation (HP:0000633)2.47763585
58Pendular nystagmus (HP:0012043)2.44640748
59Abnormal auditory evoked potentials (HP:0006958)2.44600513
60Abnormal delayed hypersensitivity skin test (HP:0002963)2.43059351
61Tubulointerstitial abnormality (HP:0001969)2.40360797
62Protruding tongue (HP:0010808)2.36427372
63Tubulointerstitial fibrosis (HP:0005576)2.34986765
64Impulsivity (HP:0100710)2.34588741
65Polyuria (HP:0000103)2.33863052
66Dysmetric saccades (HP:0000641)2.32218447
67Azoospermia (HP:0000027)2.28307746
68Anhidrosis (HP:0000970)2.26330358
69Clumsiness (HP:0002312)2.22186382
70Hypochromic anemia (HP:0001931)2.17618086
71Ileus (HP:0002595)2.14352425
72Delayed gross motor development (HP:0002194)2.13843867
73Chorioretinal atrophy (HP:0000533)2.12835420
74Congenital hepatic fibrosis (HP:0002612)2.09002665
75Pancreatic islet-cell hyperplasia (HP:0004510)2.08706317
76Adrenal hypoplasia (HP:0000835)2.07603546
77Abnormality of the prostate (HP:0008775)2.06442681
78Gaze-evoked nystagmus (HP:0000640)2.06362316
79Decreased electroretinogram (ERG) amplitude (HP:0000654)2.05963882
80Cerebellar dysplasia (HP:0007033)2.05658844
81Redundant skin (HP:0001582)2.05032051
82Abnormality of the fovea (HP:0000493)2.04638480
83Decreased central vision (HP:0007663)2.04429072
84Portal hypertension (HP:0001409)2.03213064
85Bell-shaped thorax (HP:0001591)2.02277118
86Hypophosphatemic rickets (HP:0004912)2.02228925
87Inability to walk (HP:0002540)1.99144697
88Tubulointerstitial nephritis (HP:0001970)1.98569642
89Abnormality of the nasal septum (HP:0000419)1.97053622
90Decreased skull ossification (HP:0004331)1.95536981
91Abnormal spermatogenesis (HP:0008669)1.94274430
92Type 2 muscle fiber atrophy (HP:0003554)1.93902855
93Action tremor (HP:0002345)1.92779258
94Flat occiput (HP:0005469)1.92395157
95Abnormal rod and cone electroretinograms (HP:0008323)1.92020236
96Postural tremor (HP:0002174)1.90667628
97Aplasia/Hypoplasia of the macula (HP:0008059)1.88598562
98IgM deficiency (HP:0002850)1.87899067
99Testicular atrophy (HP:0000029)1.87283142
100Hydroxyprolinuria (HP:0003080)1.84519016

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K136.52983783
2FRK5.61789957
3PBK4.02167379
4PINK13.49783305
5MAP3K73.20528053
6MAP3K142.63833183
7CDK192.36415880
8OXSR12.33145800
9BCKDK2.19064290
10ZAK2.10446163
11VRK11.98051554
12GRK11.94483745
13BRSK21.90070667
14FGFR21.76602758
15PRKG21.64444235
16MKNK11.61219731
17NUAK11.58375651
18WNK41.57742725
19MKNK21.52442669
20ADRBK21.44682231
21CAMKK21.40058228
22TAOK31.38576536
23MAP4K21.32549604
24BMPR1B1.32278600
25PIK3CA1.26061844
26CSNK1G21.23590530
27AKT31.22866857
28GRK61.19905141
29CSNK1A1L1.19721158
30PLK31.17130019
31RPS6KB21.11254840
32PRKCQ1.10902388
33CSNK1G31.09091623
34CSNK1G11.05327333
35TXK1.04165297
36MAPKAPK31.04089675
37ACVR1B1.02690853
38PRKCE0.95645503
39TGFBR10.91339620
40SYK0.88030993
41PHKG20.87914316
42PHKG10.87914316
43LATS10.87281690
44NME20.85240120
45TGFBR20.82986873
46BTK0.79884567
47FGFR30.77254608
48TEC0.76509738
49MAP4K10.68213391
50TNK20.67208129
51MAP2K60.66253345
52JAK30.65442014
53DAPK20.64692008
54MAPKAPK50.63302885
55PRKAA20.60812410
56PRKG10.58938602
57KIT0.58574589
58CHEK20.58426836
59BCR0.57814248
60IKBKB0.56988395
61TIE10.56695111
62RPS6KA50.55356316
63PLK20.50281984
64STK390.49778473
65STK38L0.47627092
66HCK0.47003091
67PTK2B0.46865255
68STK30.46236972
69CHUK0.44496311
70ADRBK10.43967678
71STK240.43198238
72YES10.41928237
73ITK0.41912025
74TRPM70.40714893
75PRKCG0.40253010
76RPS6KB10.39890725
77MAPK110.38474695
78FES0.38203999
79IKBKE0.37795747
80WNK30.37173454
81CSNK1D0.36831241
82OBSCN0.36781438
83MATK0.36364961
84GRK70.36294841
85FER0.33577030
86TLK10.32222459
87PRKCD0.32020753
88SGK10.31765396
89LCK0.30884939
90GRK50.30111406
91CSK0.27178703
92CHEK10.25386937
93LYN0.25013496
94PRKCA0.24518133
95CDK30.24404553
96PRKCI0.23576374
97MAPK90.23320992
98CSF1R0.22327061
99PDK10.22319358
100ATM0.20950344

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030203.60208974
2Selenocompound metabolism_Homo sapiens_hsa004503.15921161
3Allograft rejection_Homo sapiens_hsa053302.72386487
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.65043090
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.48988781
6Vitamin B6 metabolism_Homo sapiens_hsa007502.46773950
7Linoleic acid metabolism_Homo sapiens_hsa005912.27704919
8Ether lipid metabolism_Homo sapiens_hsa005652.14803315
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.08567964
10Arachidonic acid metabolism_Homo sapiens_hsa005901.96990946
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.93398544
12Caffeine metabolism_Homo sapiens_hsa002321.85339938
13Type I diabetes mellitus_Homo sapiens_hsa049401.85053367
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.81117741
15Taste transduction_Homo sapiens_hsa047421.76599128
16Non-homologous end-joining_Homo sapiens_hsa034501.74793593
17One carbon pool by folate_Homo sapiens_hsa006701.74716795
18Autoimmune thyroid disease_Homo sapiens_hsa053201.70703277
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.62570526
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.61634612
21Circadian rhythm_Homo sapiens_hsa047101.48925216
22T cell receptor signaling pathway_Homo sapiens_hsa046601.45036534
23Primary immunodeficiency_Homo sapiens_hsa053401.44082634
24Nitrogen metabolism_Homo sapiens_hsa009101.43473776
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.42307901
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.41327696
27Olfactory transduction_Homo sapiens_hsa047401.36849917
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.35407975
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.35244318
30Fanconi anemia pathway_Homo sapiens_hsa034601.31853753
31Basal transcription factors_Homo sapiens_hsa030221.25957895
32Retinol metabolism_Homo sapiens_hsa008301.24580779
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23909900
34Renin secretion_Homo sapiens_hsa049241.22544822
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19880681
36Long-term depression_Homo sapiens_hsa047301.19186749
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17145726
38Salivary secretion_Homo sapiens_hsa049701.16843065
39Glutathione metabolism_Homo sapiens_hsa004801.15056902
40Phototransduction_Homo sapiens_hsa047441.14128707
41Serotonergic synapse_Homo sapiens_hsa047261.13779213
42African trypanosomiasis_Homo sapiens_hsa051431.12704919
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.12532603
44Asthma_Homo sapiens_hsa053101.12312596
45Chemical carcinogenesis_Homo sapiens_hsa052041.12238627
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12181954
47Propanoate metabolism_Homo sapiens_hsa006401.10910346
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.09671097
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06773221
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03167617
51Ovarian steroidogenesis_Homo sapiens_hsa049131.02174110
52Graft-versus-host disease_Homo sapiens_hsa053320.99504043
53RNA degradation_Homo sapiens_hsa030180.98091679
54Pyrimidine metabolism_Homo sapiens_hsa002400.97908490
55Insulin secretion_Homo sapiens_hsa049110.97360041
56Dorso-ventral axis formation_Homo sapiens_hsa043200.94925704
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94753746
58Peroxisome_Homo sapiens_hsa041460.89153321
59Glycerophospholipid metabolism_Homo sapiens_hsa005640.87514008
60Homologous recombination_Homo sapiens_hsa034400.85948464
61Tryptophan metabolism_Homo sapiens_hsa003800.84773868
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.84000384
63Purine metabolism_Homo sapiens_hsa002300.82159411
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79684461
65Protein export_Homo sapiens_hsa030600.77851069
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76943346
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76797213
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75827309
69Oxytocin signaling pathway_Homo sapiens_hsa049210.75381282
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.71086400
71Thyroid hormone synthesis_Homo sapiens_hsa049180.69442788
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.67468156
73B cell receptor signaling pathway_Homo sapiens_hsa046620.66078106
74mTOR signaling pathway_Homo sapiens_hsa041500.58698938
75TNF signaling pathway_Homo sapiens_hsa046680.57320008
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.56254727
77Platelet activation_Homo sapiens_hsa046110.55279062
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.54744273
79Type II diabetes mellitus_Homo sapiens_hsa049300.51172998
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50849679
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47888867
82Systemic lupus erythematosus_Homo sapiens_hsa053220.47795948
83Circadian entrainment_Homo sapiens_hsa047130.46908309
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46768289
85Glucagon signaling pathway_Homo sapiens_hsa049220.45548424
86Herpes simplex infection_Homo sapiens_hsa051680.44091176
87Glutamatergic synapse_Homo sapiens_hsa047240.44034757
88Inositol phosphate metabolism_Homo sapiens_hsa005620.43464392
89N-Glycan biosynthesis_Homo sapiens_hsa005100.38245454
90RNA transport_Homo sapiens_hsa030130.37825873
91MAPK signaling pathway_Homo sapiens_hsa040100.33696553
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33158973
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32159230
94Fatty acid biosynthesis_Homo sapiens_hsa000610.28788250
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28691513
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27205083
97Melanoma_Homo sapiens_hsa052180.25543791
98Metabolic pathways_Homo sapiens_hsa011000.24554584
99Malaria_Homo sapiens_hsa051440.23288059
100Amphetamine addiction_Homo sapiens_hsa050310.21154790

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