COQ3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.51031576
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.89037988
3ATP synthesis coupled proton transport (GO:0015986)5.89037988
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.86936197
5respiratory electron transport chain (GO:0022904)5.51935311
6electron transport chain (GO:0022900)5.37062942
7tricarboxylic acid cycle (GO:0006099)5.31143196
8oxidative phosphorylation (GO:0006119)4.95533080
9NADH metabolic process (GO:0006734)4.57827539
10regulation of mitochondrial translation (GO:0070129)4.42246766
11proteasome assembly (GO:0043248)4.37033779
12chromatin remodeling at centromere (GO:0031055)4.32146166
13CENP-A containing nucleosome assembly (GO:0034080)4.25830958
14branched-chain amino acid catabolic process (GO:0009083)4.11412354
15regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.99462124
16ribosome assembly (GO:0042255)3.90895261
17regulation of acyl-CoA biosynthetic process (GO:0050812)3.88283461
18establishment of protein localization to mitochondrial membrane (GO:0090151)3.85976151
19DNA replication checkpoint (GO:0000076)3.81516325
20DNA double-strand break processing (GO:0000729)3.80021991
21chaperone-mediated protein transport (GO:0072321)3.75781408
22DNA damage response, detection of DNA damage (GO:0042769)3.75089381
23establishment of integrated proviral latency (GO:0075713)3.74537382
24lysine catabolic process (GO:0006554)3.74038889
25lysine metabolic process (GO:0006553)3.74038889
26mitotic metaphase plate congression (GO:0007080)3.73664618
27purine nucleobase biosynthetic process (GO:0009113)3.70404723
28succinate metabolic process (GO:0006105)3.68358756
29mitochondrial respiratory chain complex I assembly (GO:0032981)3.66499902
30NADH dehydrogenase complex assembly (GO:0010257)3.66499902
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.66499902
32protein complex biogenesis (GO:0070271)3.64084960
33regulation of cofactor metabolic process (GO:0051193)3.60653167
34regulation of coenzyme metabolic process (GO:0051196)3.60653167
35histone exchange (GO:0043486)3.60035186
36oxaloacetate metabolic process (GO:0006107)3.56600411
37cullin deneddylation (GO:0010388)3.55837076
38DNA strand elongation involved in DNA replication (GO:0006271)3.53905699
39ATP biosynthetic process (GO:0006754)3.51492487
40regulation of cellular amino acid metabolic process (GO:0006521)3.47049238
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.46504412
42branched-chain amino acid metabolic process (GO:0009081)3.46454063
43exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.45251518
44IMP biosynthetic process (GO:0006188)3.45187011
45aerobic respiration (GO:0009060)3.43255764
46telomere maintenance via semi-conservative replication (GO:0032201)3.40015443
47DNA replication-independent nucleosome assembly (GO:0006336)3.39335505
48DNA replication-independent nucleosome organization (GO:0034724)3.39335505
49DNA strand elongation (GO:0022616)3.39121662
50protein deneddylation (GO:0000338)3.38431530
51metaphase plate congression (GO:0051310)3.37811926
52mitochondrial respiratory chain complex assembly (GO:0033108)3.36075151
53cellular ketone body metabolic process (GO:0046950)3.36054492
54purine nucleoside triphosphate biosynthetic process (GO:0009145)3.35310014
55kinetochore organization (GO:0051383)3.33271628
56protein localization to kinetochore (GO:0034501)3.32552750
57regulation of sequestering of triglyceride (GO:0010889)3.31700055
58rRNA modification (GO:0000154)3.30831143
59purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.30505741
602-oxoglutarate metabolic process (GO:0006103)3.30314497
61positive regulation of ligase activity (GO:0051351)3.28347950
62replication fork processing (GO:0031297)3.28063958
63protein targeting to mitochondrion (GO:0006626)3.27475363
64negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.26584913
65nucleobase biosynthetic process (GO:0046112)3.24749726
66aspartate family amino acid catabolic process (GO:0009068)3.24103981
67L-phenylalanine metabolic process (GO:0006558)3.23670316
68erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.23670316
69inner mitochondrial membrane organization (GO:0007007)3.23556369
70aldehyde catabolic process (GO:0046185)3.22262659
71pseudouridine synthesis (GO:0001522)3.21593784
72protein neddylation (GO:0045116)3.19239248
73respiratory chain complex IV assembly (GO:0008535)3.18141939
74establishment of protein localization to mitochondrion (GO:0072655)3.17739013
75signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.16558196
76signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.16558196
77signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.16558196
78mitochondrial transport (GO:0006839)3.16498704
79DNA replication-dependent nucleosome organization (GO:0034723)3.15686124
80DNA replication-dependent nucleosome assembly (GO:0006335)3.15686124
81erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.15581430
82L-phenylalanine catabolic process (GO:0006559)3.15581430
83mitotic sister chromatid segregation (GO:0000070)3.14736669
84cellular respiration (GO:0045333)3.14156177
85positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.14059425
86negative regulation of fatty acid biosynthetic process (GO:0045717)3.12948197
87regulation of ubiquitin-protein transferase activity (GO:0051438)3.12706204
88protein localization to mitochondrion (GO:0070585)3.12600288
89intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.12383493
90signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.12383493
91kinetochore assembly (GO:0051382)3.12236837
92purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.11864752
93purine nucleoside monophosphate biosynthetic process (GO:0009127)3.11864752
94amino acid salvage (GO:0043102)3.11835760
95L-methionine salvage (GO:0071267)3.11835760
96L-methionine biosynthetic process (GO:0071265)3.11835760
97* quinone biosynthetic process (GO:1901663)3.10990159
98* ubiquinone biosynthetic process (GO:0006744)3.10990159
99glycine metabolic process (GO:0006544)3.10565987
100IMP metabolic process (GO:0046040)3.09696860
101signal transduction involved in cell cycle checkpoint (GO:0072395)3.07859996
102signal transduction involved in DNA damage checkpoint (GO:0072422)3.07809862
103signal transduction involved in DNA integrity checkpoint (GO:0072401)3.07809862
104cytochrome complex assembly (GO:0017004)3.06373805
105fatty acid beta-oxidation (GO:0006635)3.06125650
106serine family amino acid catabolic process (GO:0009071)3.04288166
107regulation of ligase activity (GO:0051340)3.01951325
108protein K6-linked ubiquitination (GO:0085020)3.01895614
109glyoxylate metabolic process (GO:0046487)3.01037544
110regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.00358286
111rRNA methylation (GO:0031167)3.00053741
112spindle checkpoint (GO:0031577)2.99871566
113somatic diversification of immune receptors via somatic mutation (GO:0002566)2.99447440
114somatic hypermutation of immunoglobulin genes (GO:0016446)2.99447440
115DNA catabolic process, exonucleolytic (GO:0000738)2.99131948
116NAD metabolic process (GO:0019674)2.98625599
117anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.98160310
118spliceosomal snRNP assembly (GO:0000387)2.97481870
119negative regulation of DNA-dependent DNA replication (GO:2000104)2.97171496
120telomere maintenance via recombination (GO:0000722)2.96918543
121acetyl-CoA metabolic process (GO:0006084)2.96317264
122negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.95171506
123negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.95171506
124negative regulation of mitotic sister chromatid segregation (GO:0033048)2.95171506
125negative regulation of mitotic sister chromatid separation (GO:2000816)2.95171506
126negative regulation of sister chromatid segregation (GO:0033046)2.95171506
127mitochondrial RNA metabolic process (GO:0000959)2.94975433
128nucleotide-excision repair, DNA gap filling (GO:0006297)2.93527402
129mitotic recombination (GO:0006312)2.93410710
130protein-cofactor linkage (GO:0018065)2.93324822
131maturation of 5.8S rRNA (GO:0000460)2.93245973
132fatty acid catabolic process (GO:0009062)2.91581618
133negative regulation of chromosome segregation (GO:0051985)2.91498246
134carnitine shuttle (GO:0006853)2.91415093
135establishment of viral latency (GO:0019043)2.91346796
136hydrogen ion transmembrane transport (GO:1902600)2.91059064
137cellular component biogenesis (GO:0044085)2.90428678
138ribosomal large subunit biogenesis (GO:0042273)2.90381403
139mitotic spindle checkpoint (GO:0071174)2.90113537
140regulation of sulfur metabolic process (GO:0042762)2.89859937
141fatty acid transmembrane transport (GO:1902001)2.89564553
142ketone body metabolic process (GO:1902224)2.89224143
143transcription elongation from RNA polymerase III promoter (GO:0006385)2.88406292
144termination of RNA polymerase III transcription (GO:0006386)2.88406292
145regulation of oxidative phosphorylation (GO:0002082)2.88177630
146negative regulation of ligase activity (GO:0051352)2.87936106
147negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.87936106
148cysteine metabolic process (GO:0006534)2.87030079
149ribonucleoside triphosphate biosynthetic process (GO:0009201)2.86266673
150organelle disassembly (GO:1903008)2.85968746
151positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.85672139
152aromatic amino acid family catabolic process (GO:0009074)2.85256944
153regulation of cellular respiration (GO:0043457)2.81555618
154pantothenate metabolic process (GO:0015939)2.81296499
155serine family amino acid metabolic process (GO:0009069)2.80502037
156L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.79638642
157metallo-sulfur cluster assembly (GO:0031163)2.79083988
158iron-sulfur cluster assembly (GO:0016226)2.79083988
159kynurenine metabolic process (GO:0070189)2.77740394
160DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.77368094
161intracellular protein transmembrane import (GO:0044743)2.77214988
162arginine metabolic process (GO:0006525)2.75393563

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.74674160
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.58703718
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.43058119
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.02081732
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.84497796
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.78439223
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.59302106
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.55731936
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.50506292
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.49020735
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.21643454
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.06591972
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.73570016
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69850021
15ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.62437723
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.61977083
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.60167956
18* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.58012685
19EGR1_23403033_ChIP-Seq_LIVER_Mouse2.56412049
20CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.55785338
21E2F7_22180533_ChIP-Seq_HELA_Human2.49395460
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.46685344
23* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.38902756
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.25616318
25RXR_22158963_ChIP-Seq_LIVER_Mouse2.22005033
26* DCP1A_22483619_ChIP-Seq_HELA_Human2.21694977
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.20955283
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.20147597
29* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19111033
30MYC_19079543_ChIP-ChIP_MESCs_Mouse2.12158466
31PPARA_22158963_ChIP-Seq_LIVER_Mouse2.11283665
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.07873632
33YY1_21170310_ChIP-Seq_MESCs_Mouse2.07100383
34VDR_23849224_ChIP-Seq_CD4+_Human2.04960170
35THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04367632
36SALL1_21062744_ChIP-ChIP_HESCs_Human2.00680275
37ZNF274_21170338_ChIP-Seq_K562_Hela1.81770397
38* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.81340650
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81314943
40FOXP3_21729870_ChIP-Seq_TREG_Human1.78946134
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.73859635
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.72544181
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70936511
44KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.67643122
45XRN2_22483619_ChIP-Seq_HELA_Human1.66669347
46EWS_26573619_Chip-Seq_HEK293_Human1.62858169
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62540324
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60746527
49* GABP_19822575_ChIP-Seq_HepG2_Human1.60342201
50E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54705603
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53912246
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.52759723
53ELK1_19687146_ChIP-ChIP_HELA_Human1.50764133
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48981063
55AR_21909140_ChIP-Seq_LNCAP_Human1.48273701
56* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.47067955
57BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.46298561
58FUS_26573619_Chip-Seq_HEK293_Human1.45413937
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44993833
60FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.43381978
61FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.41163370
62TTF2_22483619_ChIP-Seq_HELA_Human1.38807865
63VDR_22108803_ChIP-Seq_LS180_Human1.37306564
64LXR_22158963_ChIP-Seq_LIVER_Mouse1.30274504
65* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30231482
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26606557
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23387308
68IGF1R_20145208_ChIP-Seq_DFB_Human1.19614286
69NANOG_16153702_ChIP-ChIP_HESCs_Human1.18507965
70MYC_18940864_ChIP-ChIP_HL60_Human1.16239659
71ELK1_22589737_ChIP-Seq_MCF10A_Human1.14990969
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13916412
73NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13476649
74* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13456650
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12960911
76CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.12732439
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12349798
78SOX2_16153702_ChIP-ChIP_HESCs_Human1.09867181
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09477967
80KAP1_22055183_ChIP-Seq_ESCs_Mouse1.08474202
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08094600
82* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07196277
83CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06910054
84ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06245391
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00183461
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97682237
87* SOX17_20123909_ChIP-Seq_XEN_Mouse0.97419935
88SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97225362
89ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96339112
90HTT_18923047_ChIP-ChIP_STHdh_Human0.96298354
91* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93788378
92SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.89907496
93TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89433783
94GATA4_21415370_ChIP-Seq_HL-1_Mouse0.89008943
95NOTCH1_21737748_ChIP-Seq_TLL_Human0.87473424
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86480109
97POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85913969
98NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.84488365
99PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.84257906
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.83664234
101KDM5A_27292631_Chip-Seq_BREAST_Human0.82707032
102CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.82647490
103* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81535823
104ZNF263_19887448_ChIP-Seq_K562_Human0.80119233
105CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.79479905
106STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.78404904
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.78338664
108MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.77564600
109PCGF2_27294783_Chip-Seq_ESCs_Mouse0.77409818
110SOX2_18692474_ChIP-Seq_MEFs_Mouse0.75510061
111NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.75054884
112FLI1_27457419_Chip-Seq_LIVER_Mouse0.74570286
113P300_19829295_ChIP-Seq_ESCs_Human0.73934653
114OCT4_18692474_ChIP-Seq_MEFs_Mouse0.73458245
115E2F1_21310950_ChIP-Seq_MCF-7_Human0.73106076
116SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.71657366
117TAF15_26573619_Chip-Seq_HEK293_Human0.71280469
118ERG_20887958_ChIP-Seq_HPC-7_Mouse0.70879560
119AUTS2_25519132_ChIP-Seq_293T-REX_Human0.70756541
120PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.70410664
121CTBP1_25329375_ChIP-Seq_LNCAP_Human0.69963878
122TP53_22573176_ChIP-Seq_HFKS_Human0.69730435
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.69288894
124IRF1_19129219_ChIP-ChIP_H3396_Human0.67777385
125SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.66911827
126KLF4_18555785_ChIP-Seq_MESCs_Mouse0.66476063
127CTCF_18555785_ChIP-Seq_MESCs_Mouse0.66292774
128* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.65172060
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.65040306
130ZFP57_27257070_Chip-Seq_ESCs_Mouse0.64856658
131TP63_19390658_ChIP-ChIP_HaCaT_Human0.64723759
132FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.63110289
133CIITA_25753668_ChIP-Seq_RAJI_Human0.62429017

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.82986369
2MP0003646_muscle_fatigue4.69525624
3MP0002837_dystrophic_cardiac_calcinosis4.35106978
4MP0002139_abnormal_hepatobiliary_system3.61686440
5MP0005085_abnormal_gallbladder_physiolo3.45793549
6MP0005360_urolithiasis3.26927452
7MP0006036_abnormal_mitochondrial_physio3.25754972
8MP0004084_abnormal_cardiac_muscle2.96710372
9MP0005365_abnormal_bile_salt2.69543601
10MP0004215_abnormal_myocardial_fiber2.60858782
11MP0003186_abnormal_redox_activity2.59563981
12MP0008875_abnormal_xenobiotic_pharmacok2.55676957
13MP0004036_abnormal_muscle_relaxation2.50418127
14MP0008007_abnormal_cellular_replicative2.50235569
15MP0006035_abnormal_mitochondrial_morpho2.45763799
16MP0005332_abnormal_amino_acid2.44313486
17MP0006292_abnormal_olfactory_placode2.43340679
18MP0005330_cardiomyopathy2.35416161
19MP0004130_abnormal_muscle_cell2.22143917
20MP0000749_muscle_degeneration2.20374508
21MP0008775_abnormal_heart_ventricle2.15045934
22MP0003718_maternal_effect2.12228507
23MP0003693_abnormal_embryo_hatching2.06901482
24MP0000751_myopathy1.97956141
25MP0009697_abnormal_copulation1.91963045
26MP0009840_abnormal_foam_cell1.89662577
27MP0003195_calcinosis1.83797981
28MP0001293_anophthalmia1.82530397
29MP0010329_abnormal_lipoprotein_level1.82475402
30MP0002269_muscular_atrophy1.81092059
31MP0005451_abnormal_body_composition1.81088626
32MP0005670_abnormal_white_adipose1.79214217
33MP0002876_abnormal_thyroid_physiology1.73830975
34MP0005266_abnormal_metabolism1.69359511
35MP0003941_abnormal_skin_development1.69039452
36MP0003221_abnormal_cardiomyocyte_apopto1.65182054
37MP0002332_abnormal_exercise_endurance1.64525415
38MP0001764_abnormal_homeostasis1.54360205
39MP0002972_abnormal_cardiac_muscle1.53825557
40MP0004957_abnormal_blastocyst_morpholog1.52007705
41MP0008789_abnormal_olfactory_epithelium1.50462676
42MP0002938_white_spotting1.50272128
43MP0005385_cardiovascular_system_phenoty1.50182041
44MP0001544_abnormal_cardiovascular_syste1.50182041
45MP0010094_abnormal_chromosome_stability1.47193316
46MP0005620_abnormal_muscle_contractility1.45119575
47MP0004145_abnormal_muscle_electrophysio1.43900851
48MP0003111_abnormal_nucleus_morphology1.43124237
49MP0005319_abnormal_enzyme/_coenzyme1.41671387
50MP0005083_abnormal_biliary_tract1.41561202
51MP0003137_abnormal_impulse_conducting1.38018334
52MP0001529_abnormal_vocalization1.35628544
53MP0004147_increased_porphyrin_level1.33268401
54MP0002102_abnormal_ear_morphology1.33103568
55MP0003937_abnormal_limbs/digits/tail_de1.32568680
56MP0002234_abnormal_pharynx_morphology1.32553286
57MP0003890_abnormal_embryonic-extraembry1.31643466
58MP0002160_abnormal_reproductive_system1.31173326
59MP0003656_abnormal_erythrocyte_physiolo1.30944564
60MP0002210_abnormal_sex_determination1.28549149
61MP0004087_abnormal_muscle_fiber1.26954622
62MP0006138_congestive_heart_failure1.26274583
63MP0000750_abnormal_muscle_regeneration1.24794601
64MP0002118_abnormal_lipid_homeostasis1.22531367
65MP0001929_abnormal_gametogenesis1.22112840
66MP0005666_abnormal_adipose_tissue1.21691277
67MP0005584_abnormal_enzyme/coenzyme_acti1.21000144
68MP0002736_abnormal_nociception_after1.20162739
69MP0004133_heterotaxia1.20116225
70MP0002106_abnormal_muscle_physiology1.19275165
71MP0004233_abnormal_muscle_weight1.18230304
72MP0001730_embryonic_growth_arrest1.17357346
73MP0003123_paternal_imprinting1.16884516
74MP0004019_abnormal_vitamin_homeostasis1.16622472
75MP0001188_hyperpigmentation1.15815648
76MP0008995_early_reproductive_senescence1.15477692
77MP0004484_altered_response_of1.14139235
78MP0000747_muscle_weakness1.14128825
79MP0000609_abnormal_liver_physiology1.12425257
80MP0003011_delayed_dark_adaptation1.10928601
81MP0003880_abnormal_central_pattern1.09668516
82MP0000372_irregular_coat_pigmentation1.09386372
83MP0009379_abnormal_foot_pigmentation1.06335049
84MP0010030_abnormal_orbit_morphology1.05406690
85MP0005535_abnormal_body_temperature1.05404081
86MP0001697_abnormal_embryo_size1.03967429
87MP0005376_homeostasis/metabolism_phenot1.03638852
88MP0001485_abnormal_pinna_reflex1.02791286
89MP0000350_abnormal_cell_proliferation1.02522436
90MP0003121_genomic_imprinting1.01211260
91MP0006072_abnormal_retinal_apoptosis1.00475951
92MP0001145_abnormal_male_reproductive0.99819906
93MP0001666_abnormal_nutrient_absorption0.99683904
94MP0000653_abnormal_sex_gland0.98977502
95MP0008932_abnormal_embryonic_tissue0.96074302
96MP0002127_abnormal_cardiovascular_syste0.95012680
97MP0006276_abnormal_autonomic_nervous0.94550644
98MP0008877_abnormal_DNA_methylation0.94533997
99MP0003136_yellow_coat_color0.93434354
100MP0005369_muscle_phenotype0.93006000
101MP0000358_abnormal_cell_content/0.92575998
102MP0000313_abnormal_cell_death0.92388634
103MP0005551_abnormal_eye_electrophysiolog0.92119324
104MP0005389_reproductive_system_phenotype0.92027533
105MP0002085_abnormal_embryonic_tissue0.92003484
106MP0005084_abnormal_gallbladder_morpholo0.90855466
107MP0005394_taste/olfaction_phenotype0.87281521
108MP0005499_abnormal_olfactory_system0.87281521
109MP0003698_abnormal_male_reproductive0.86704198
110MP0005636_abnormal_mineral_homeostasis0.86011271
111MP0000759_abnormal_skeletal_muscle0.85089400
112MP0003191_abnormal_cellular_cholesterol0.83284228
113MP0000647_abnormal_sebaceous_gland0.83103167
114MP0002080_prenatal_lethality0.82633120
115MP0009672_abnormal_birth_weight0.82579149
116MP0002084_abnormal_developmental_patter0.81595310
117MP0002971_abnormal_brown_adipose0.79955188
118MP0000049_abnormal_middle_ear0.79352812
119MP0003077_abnormal_cell_cycle0.79170534
120MP0002751_abnormal_autonomic_nervous0.78924677
121MP0001968_abnormal_touch/_nociception0.78637514
122MP0000631_abnormal_neuroendocrine_gland0.78276148
123MP0002233_abnormal_nose_morphology0.77537958
124MP0003119_abnormal_digestive_system0.76447599
125MP0001919_abnormal_reproductive_system0.75942666
126MP0003786_premature_aging0.75420055
127MP0005380_embryogenesis_phenotype0.75144155
128MP0001672_abnormal_embryogenesis/_devel0.75144155
129MP0001727_abnormal_embryo_implantation0.75003837
130MP0009046_muscle_twitch0.74282924
131MP0001286_abnormal_eye_development0.73391209
132MP0008057_abnormal_DNA_replication0.71173674
133MP0001984_abnormal_olfaction0.71071678
134MP0001542_abnormal_bone_strength0.70100095
135MP0009643_abnormal_urine_homeostasis0.69773284
136MP0003755_abnormal_palate_morphology0.69561670
137MP0010630_abnormal_cardiac_muscle0.69515409
138MP0004085_abnormal_heartbeat0.69049584
139MP0009250_abnormal_appendicular_skeleto0.68244025
140MP0005408_hypopigmentation0.68227752
141MP0002653_abnormal_ependyma_morphology0.67499083
142MP0005395_other_phenotype0.67238695
143MP0004510_myositis0.67228048
144MP0001119_abnormal_female_reproductive0.66292324
145MP0001905_abnormal_dopamine_level0.65751499
146MP0008872_abnormal_physiological_respon0.65488596
147MP0004142_abnormal_muscle_tone0.65309480
148MP0003315_abnormal_perineum_morphology0.64726695
149MP0001661_extended_life_span0.64609585
150MP0003567_abnormal_fetal_cardiomyocyte0.63998071
151MP0003787_abnormal_imprinting0.63664092
152MP0002111_abnormal_tail_morphology0.63513011
153MP0004185_abnormal_adipocyte_glucose0.63293086
154MP0002161_abnormal_fertility/fecundity0.63019928
155MP0008058_abnormal_DNA_repair0.61843529
156MP0002822_catalepsy0.61333149
157MP0010307_abnormal_tumor_latency0.61024998
158MP0005165_increased_susceptibility_to0.61011450
159MP0000343_altered_response_to0.60269408
160MP0003950_abnormal_plasma_membrane0.60151572
161MP0002078_abnormal_glucose_homeostasis0.60136002
162MP0004043_abnormal_pH_regulation0.59578942
163MP0009763_increased_sensitivity_to0.58949663
164MP0005375_adipose_tissue_phenotype0.58637086

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.54175205
2Abnormal mitochondria in muscle tissue (HP:0008316)5.25031649
3Acute encephalopathy (HP:0006846)5.03223944
4Hepatic necrosis (HP:0002605)5.02687880
5Mitochondrial inheritance (HP:0001427)4.99144929
6Hepatocellular necrosis (HP:0001404)4.81514223
7Increased CSF lactate (HP:0002490)4.80528133
8Cerebral edema (HP:0002181)4.70985631
9Progressive macrocephaly (HP:0004481)4.51223678
10Abnormality of glycolysis (HP:0004366)4.33288290
11Increased serum pyruvate (HP:0003542)4.33288290
12Lipid accumulation in hepatocytes (HP:0006561)4.00170948
13Increased hepatocellular lipid droplets (HP:0006565)3.90425000
14Lactic acidosis (HP:0003128)3.80405293
15Increased serum lactate (HP:0002151)3.65377248
16Hyperglycinuria (HP:0003108)3.60739847
17Increased muscle lipid content (HP:0009058)3.58030920
18Increased intramyocellular lipid droplets (HP:0012240)3.55965104
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.46333153
20Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.45004514
21Abnormality of alanine metabolism (HP:0010916)3.45004514
22Hyperalaninemia (HP:0003348)3.45004514
23Lethargy (HP:0001254)3.44781143
24Abnormality of the labia minora (HP:0012880)3.38161527
25Abnormality of fatty-acid metabolism (HP:0004359)3.33951345
26Dicarboxylic aciduria (HP:0003215)3.33029869
27Abnormality of dicarboxylic acid metabolism (HP:0010995)3.33029869
28Hyperglycinemia (HP:0002154)3.31599304
29Abnormality of glycine metabolism (HP:0010895)3.29927613
30Abnormality of serine family amino acid metabolism (HP:0010894)3.29927613
31Exercise intolerance (HP:0003546)3.27166411
32Respiratory failure (HP:0002878)3.26504271
33Decreased activity of mitochondrial respiratory chain (HP:0008972)3.13151840
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.13151840
35Abnormality of serum amino acid levels (HP:0003112)3.09339902
36Nausea (HP:0002018)3.07359767
37Hyperammonemia (HP:0001987)3.03454090
38Chromsome breakage (HP:0040012)3.02199069
39Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.01103602
40Renal Fanconi syndrome (HP:0001994)2.99665265
41CNS demyelination (HP:0007305)2.98351504
42Palpitations (HP:0001962)2.96889218
43Abnormality of the preputium (HP:0100587)2.92788204
443-Methylglutaconic aciduria (HP:0003535)2.92143406
45Meckel diverticulum (HP:0002245)2.86619595
46Chromosomal breakage induced by crosslinking agents (HP:0003221)2.85480863
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.81892703
48Hypobetalipoproteinemia (HP:0003563)2.78687334
49Abnormality of chromosome stability (HP:0003220)2.77154685
50Calf muscle hypertrophy (HP:0008981)2.76794445
51Abnormality of the ileum (HP:0001549)2.76793909
52Type I transferrin isoform profile (HP:0003642)2.74161127
53Volvulus (HP:0002580)2.74025620
54Rhabdomyolysis (HP:0003201)2.73108654
55Optic disc pallor (HP:0000543)2.72050260
56Myoglobinuria (HP:0002913)2.68380912
57Hypoglycemic coma (HP:0001325)2.67150240
58Reduced antithrombin III activity (HP:0001976)2.63449913
59Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.58974890
60Abnormality of aromatic amino acid family metabolism (HP:0004338)2.57589820
61Muscle hypertrophy of the lower extremities (HP:0008968)2.57197866
62Generalized aminoaciduria (HP:0002909)2.55830798
63Sudden death (HP:0001699)2.55320713
64Respiratory difficulties (HP:0002880)2.53823820
65Leukodystrophy (HP:0002415)2.53093335
66Reticulocytopenia (HP:0001896)2.52671394
67Hyperlipoproteinemia (HP:0010980)2.50426069
68Pheochromocytoma (HP:0002666)2.45155166
69Glycosuria (HP:0003076)2.44987950
70Abnormality of urine glucose concentration (HP:0011016)2.44987950
71Vomiting (HP:0002013)2.40564511
72Hypolipoproteinemia (HP:0010981)2.39664747
73Ragged-red muscle fibers (HP:0003200)2.38833040
74Methylmalonic aciduria (HP:0012120)2.35674925
75Neuroendocrine neoplasm (HP:0100634)2.34727956
76Intrahepatic cholestasis (HP:0001406)2.30540688
77Ketosis (HP:0001946)2.30027943
78Colon cancer (HP:0003003)2.27662734
79Abnormal lung lobation (HP:0002101)2.27172687
80Amniotic constriction ring (HP:0009775)2.25813854
81Abnormality of placental membranes (HP:0011409)2.25813854
82Metabolic acidosis (HP:0001942)2.23822425
83Macrocytic anemia (HP:0001972)2.23256889
84Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.22716599
85Ependymoma (HP:0002888)2.22571563
86Small intestinal stenosis (HP:0012848)2.22533628
87Duodenal stenosis (HP:0100867)2.22533628
88Pancreatic fibrosis (HP:0100732)2.22090786
89Exercise-induced myalgia (HP:0003738)2.21476540
90Hypoalphalipoproteinemia (HP:0003233)2.19622202
91Pancreatic cysts (HP:0001737)2.19505687
92Birth length less than 3rd percentile (HP:0003561)2.17844600
93Multiple enchondromatosis (HP:0005701)2.17164748
94Exertional dyspnea (HP:0002875)2.17106619
95Proximal tubulopathy (HP:0000114)2.16787451
96Xanthomatosis (HP:0000991)2.16196584
97Abnormality of monocarboxylic acid metabolism (HP:0010996)2.15424392
98Abnormality of methionine metabolism (HP:0010901)2.14751157
99Abnormal number of erythroid precursors (HP:0012131)2.14006534
100Emotional lability (HP:0000712)2.13826124
101Microvesicular hepatic steatosis (HP:0001414)2.12286636
102Gliosis (HP:0002171)2.11085538
103Ventricular tachycardia (HP:0004756)2.10758865
104Exercise-induced muscle cramps (HP:0003710)2.10024026
105Abnormality of aspartate family amino acid metabolism (HP:0010899)2.09481569
106Abnormality of cells of the erythroid lineage (HP:0012130)2.08655843
107True hermaphroditism (HP:0010459)2.06764149
108Abnormality of the anterior horn cell (HP:0006802)2.06167635
109Degeneration of anterior horn cells (HP:0002398)2.06167635
110Abnormal protein glycosylation (HP:0012346)2.04642764
111Abnormal glycosylation (HP:0012345)2.04642764
112Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.04642764
113Abnormal protein N-linked glycosylation (HP:0012347)2.04642764
114Testicular atrophy (HP:0000029)2.01096778
115Ketoacidosis (HP:0001993)1.99389946
116Cholelithiasis (HP:0001081)1.98712177
117Hypoplasia of the pons (HP:0012110)1.97919965
118Methylmalonic acidemia (HP:0002912)1.97013495
119Renal cortical cysts (HP:0000803)1.97009076
120Triphalangeal thumb (HP:0001199)1.96967801
121Sloping forehead (HP:0000340)1.95813979
122Lipoatrophy (HP:0100578)1.94874281
123Cerebral hypomyelination (HP:0006808)1.93737114
124Abnormality of midbrain morphology (HP:0002418)1.93283814
125Molar tooth sign on MRI (HP:0002419)1.93283814
126Abnormality of the pons (HP:0007361)1.92781328
127Absent thumb (HP:0009777)1.91968126
128Prolonged partial thromboplastin time (HP:0003645)1.91256647
129Carpal bone hypoplasia (HP:0001498)1.89431763
130Muscle fiber splitting (HP:0003555)1.88783898
131Abnormality of the duodenum (HP:0002246)1.88160697
132Oral leukoplakia (HP:0002745)1.88026449
133Supernumerary spleens (HP:0009799)1.86815727
134X-linked dominant inheritance (HP:0001423)1.85185289
135Abnormality of pyrimidine metabolism (HP:0004353)1.85183973
136Abnormality of renal resorption (HP:0011038)1.85005287
137Neoplasm of head and neck (HP:0012288)1.84670839
138Esophageal neoplasm (HP:0100751)1.84670839
139Progressive external ophthalmoplegia (HP:0000590)1.83951585
140Abnormal gallbladder morphology (HP:0012437)1.80961797
141Conjunctival hamartoma (HP:0100780)1.78743753
142Clubbing of toes (HP:0100760)1.77929464
143Megaloblastic anemia (HP:0001889)1.75855241
144Pancytopenia (HP:0001876)1.73321826
145Abnormality of the carotid arteries (HP:0005344)1.70481722
146Pallor (HP:0000980)1.69319986
147Glioma (HP:0009733)1.68266496
148Sclerocornea (HP:0000647)1.67654302
149Medial flaring of the eyebrow (HP:0010747)1.67044033

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.60638320
2NME23.41936819
3BUB13.26684732
4NEK13.22622937
5PDK43.21573306
6PDK33.21573306
7VRK22.94785541
8TRIM282.83780101
9EIF2AK12.63404686
10NME12.55183661
11OBSCN2.44886344
12TNIK2.33785638
13STK162.27376095
14WEE12.07688095
15WNK32.05397553
16TSSK62.01641483
17ZAK2.01160750
18MYLK1.94166801
19PDK21.90186317
20ARAF1.88535177
21SRPK11.85956546
22BRSK21.78493174
23BRAF1.74346353
24MAP2K71.69493385
25PBK1.68468031
26PINK11.59816835
27MAP3K121.56537579
28BMPR1B1.55784234
29STK38L1.53805341
30NUAK11.52629682
31PLK41.49739990
32AKT31.48131352
33TTN1.42934464
34NEK91.40859021
35MAP3K41.38071777
36ABL21.34157743
37NEK21.32937988
38PIK3CA1.32161526
39PLK31.32115321
40EIF2AK31.26867632
41TAOK21.22123689
42PHKG11.20292465
43PHKG21.20292465
44MAP2K41.17155638
45TLK11.14883008
46TTK1.11896643
47PNCK1.09129769
48GRK71.01349777
49AURKA0.99256562
50EPHA40.99132519
51CCNB10.97987850
52PLK10.97314330
53CASK0.95528560
54MAPK130.92456113
55BRSK10.90958485
56MAP4K20.90828196
57ACVR1B0.90619804
58PIK3CG0.90202038
59TAF10.83736487
60STK240.83350563
61DYRK30.78489207
62ERBB30.78373810
63ERBB40.77744377
64PLK20.75990249
65VRK10.75850155
66PASK0.74804134
67LMTK20.74700172
68MAPKAPK50.73494013
69MAP3K110.72982107
70ATM0.71831312
71AURKB0.68773058
72GRK10.66703875
73CSNK1G30.64799145
74CHEK10.64443809
75CSNK1G10.63295223
76CDK80.62930934
77LATS20.62728267
78CAMK2G0.61912618
79CSNK2A10.61507701
80DAPK30.61317320
81MINK10.61296155
82ALK0.60885818
83IRAK30.60560905
84CLK10.58470657
85PRKCG0.58363173
86CSNK1G20.58009791
87FRK0.57674232
88CHEK20.57250641
89CDC70.56642180
90CSNK2A20.56090840
91MAP3K50.56036504
92WNK40.53149881
93OXSR10.52693735
94MAPKAPK30.51300679
95TGFBR10.50922407
96EIF2AK20.50504800
97LIMK10.50437562
98RPS6KA40.50198502
99INSRR0.50064143
100BCR0.48939370
101MUSK0.47463360
102MKNK20.46796903
103BMPR20.46696895
104DAPK20.45155866
105ADRBK20.45136183
106MST1R0.43208212
107CAMK2A0.43004253
108CDK30.42772191
109DAPK10.42027107
110CDK10.41866443
111RPS6KB20.41092378
112PRKDC0.40729650
113CAMK2D0.40455511
114MARK10.39937818
115TIE10.39526267
116MKNK10.36305255
117MST40.35878943
118MAP3K80.35300921
119PRKCI0.35112868
120PKN10.35087909
121STK40.35041867
122PRKACA0.35003258
123RPS6KA50.34709449
124CDK20.34469351
125CSNK1A1L0.33679162
126ADRBK10.31474837
127MAP2K10.30789610
128CDK190.30745526
129AKT20.30189334
130MAPK110.29832558
131CSNK1A10.29765058
132MARK30.29133464
133MAP3K90.28192426
134DYRK20.28165480
135MAP2K60.28059191
136PRKCE0.27289010
137CDK40.27255685
138GRK50.27222725
139PRKAA10.25776708
140EPHA20.24150687
141CSNK1E0.24036024
142ATR0.23727287
143PRKACG0.23331502
144RPS6KL10.23034735
145RPS6KC10.23034735

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.66889793
2Oxidative phosphorylation_Homo sapiens_hsa001903.64898507
3Parkinsons disease_Homo sapiens_hsa050123.22023251
4Proteasome_Homo sapiens_hsa030503.07014363
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.95041878
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61602128
7Propanoate metabolism_Homo sapiens_hsa006402.58049518
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.55258370
9Non-homologous end-joining_Homo sapiens_hsa034502.37670221
10Huntingtons disease_Homo sapiens_hsa050162.26969771
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.22297450
12Alzheimers disease_Homo sapiens_hsa050102.20003650
13Carbon metabolism_Homo sapiens_hsa012002.10653939
14Fatty acid degradation_Homo sapiens_hsa000712.06855429
15RNA polymerase_Homo sapiens_hsa030202.02745821
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.01504126
17Pyruvate metabolism_Homo sapiens_hsa006201.98651580
18Vitamin B6 metabolism_Homo sapiens_hsa007501.96786252
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.84287891
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.77704815
21Ribosome_Homo sapiens_hsa030101.74347515
22Butanoate metabolism_Homo sapiens_hsa006501.67901579
23Peroxisome_Homo sapiens_hsa041461.64620035
24Cardiac muscle contraction_Homo sapiens_hsa042601.64304812
25Fatty acid metabolism_Homo sapiens_hsa012121.63323850
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55520108
27Arginine biosynthesis_Homo sapiens_hsa002201.54498545
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.54423886
29Fatty acid elongation_Homo sapiens_hsa000621.53955715
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52356872
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.51505284
32Biosynthesis of amino acids_Homo sapiens_hsa012301.51210927
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.51086162
34* Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46203957
35Tryptophan metabolism_Homo sapiens_hsa003801.39421427
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.35526536
37beta-Alanine metabolism_Homo sapiens_hsa004101.33803915
38Pyrimidine metabolism_Homo sapiens_hsa002401.25873193
39Phenylalanine metabolism_Homo sapiens_hsa003601.25851458
40PPAR signaling pathway_Homo sapiens_hsa033201.22067048
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20220862
42Folate biosynthesis_Homo sapiens_hsa007901.17800320
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.15489882
44DNA replication_Homo sapiens_hsa030301.14380742
45Sulfur metabolism_Homo sapiens_hsa009201.10731947
46Tyrosine metabolism_Homo sapiens_hsa003501.10676392
47Chemical carcinogenesis_Homo sapiens_hsa052041.09690567
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07377920
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07075422
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06818755
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.05040983
52One carbon pool by folate_Homo sapiens_hsa006701.04781721
53Pentose phosphate pathway_Homo sapiens_hsa000301.04426298
54Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04220496
55Drug metabolism - other enzymes_Homo sapiens_hsa009831.04208413
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03271437
57Nucleotide excision repair_Homo sapiens_hsa034200.98270940
58Glutathione metabolism_Homo sapiens_hsa004800.97759487
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96245339
60Mismatch repair_Homo sapiens_hsa034300.95988773
61Homologous recombination_Homo sapiens_hsa034400.93366228
62* Metabolic pathways_Homo sapiens_hsa011000.91791426
63RNA transport_Homo sapiens_hsa030130.90622732
64Fructose and mannose metabolism_Homo sapiens_hsa000510.90578018
65Histidine metabolism_Homo sapiens_hsa003400.89771015
66Arginine and proline metabolism_Homo sapiens_hsa003300.87623029
67Sulfur relay system_Homo sapiens_hsa041220.84645631
68Oocyte meiosis_Homo sapiens_hsa041140.76880386
69Purine metabolism_Homo sapiens_hsa002300.76556966
70Complement and coagulation cascades_Homo sapiens_hsa046100.74704408
71mRNA surveillance pathway_Homo sapiens_hsa030150.70172184
72Phototransduction_Homo sapiens_hsa047440.70071517
73Retinol metabolism_Homo sapiens_hsa008300.69685009
74Collecting duct acid secretion_Homo sapiens_hsa049660.66313903
75Starch and sucrose metabolism_Homo sapiens_hsa005000.66035161
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.63112227
77Selenocompound metabolism_Homo sapiens_hsa004500.60467828
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58885729
79p53 signaling pathway_Homo sapiens_hsa041150.58866830
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57705461
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54643908
82Regulation of autophagy_Homo sapiens_hsa041400.54256012
83Nitrogen metabolism_Homo sapiens_hsa009100.52305982
84Fat digestion and absorption_Homo sapiens_hsa049750.52211901
85Galactose metabolism_Homo sapiens_hsa000520.51808270
86N-Glycan biosynthesis_Homo sapiens_hsa005100.50371945
87Glycerolipid metabolism_Homo sapiens_hsa005610.50092282
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.46645618
89Base excision repair_Homo sapiens_hsa034100.46061623
90Spliceosome_Homo sapiens_hsa030400.42953067
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42479729
92Protein export_Homo sapiens_hsa030600.41143894
93Fatty acid biosynthesis_Homo sapiens_hsa000610.39394874
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35806493
95Caffeine metabolism_Homo sapiens_hsa002320.33663520
96Basal transcription factors_Homo sapiens_hsa030220.32502709
97Nicotine addiction_Homo sapiens_hsa050330.31746610
98Linoleic acid metabolism_Homo sapiens_hsa005910.31443919
99RNA degradation_Homo sapiens_hsa030180.29739712
100Arachidonic acid metabolism_Homo sapiens_hsa005900.29408100
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26763904
102Vitamin digestion and absorption_Homo sapiens_hsa049770.26268336
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25601556
104Fanconi anemia pathway_Homo sapiens_hsa034600.24704981
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.24267051
106Staphylococcus aureus infection_Homo sapiens_hsa051500.23974883
107Taste transduction_Homo sapiens_hsa047420.23390220
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.21274486
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21119080
110Epstein-Barr virus infection_Homo sapiens_hsa051690.20471753
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.20015677
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19878729
113Cell cycle_Homo sapiens_hsa041100.17416551
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15424709
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.13647433
116Steroid biosynthesis_Homo sapiens_hsa001000.13415030

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