COQ4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the coenzyme Q biosynthesis pathway. Coenzyme Q, an essential component of the electron transport chain, shuttles electrons between complexes I or II to complex III of the mitochondrial transport chain. This protein appears to play a structural role in stabilizing a complex that contains most of the coenzyme Q biosynthesis enzymes. Mutations in this gene are associated with mitochondrial disorders linked to coenzyme Q deficiency. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)7.01176722
2DNA deamination (GO:0045006)6.44582828
3cilium movement (GO:0003341)5.85072373
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.75499494
5epithelial cilium movement (GO:0003351)5.70731076
6cilium or flagellum-dependent cell motility (GO:0001539)5.60965213
7behavioral response to nicotine (GO:0035095)5.41573830
8axoneme assembly (GO:0035082)5.23805823
9motile cilium assembly (GO:0044458)5.17128847
10proteasome assembly (GO:0043248)4.58640738
11regulation of cilium movement (GO:0003352)4.45142497
12purine nucleobase biosynthetic process (GO:0009113)4.33771466
13transcription elongation from RNA polymerase III promoter (GO:0006385)4.25979732
14termination of RNA polymerase III transcription (GO:0006386)4.25979732
15nucleobase biosynthetic process (GO:0046112)4.15929982
16spliceosomal snRNP assembly (GO:0000387)4.08141005
17ribosomal small subunit assembly (GO:0000028)4.04428514
18cullin deneddylation (GO:0010388)4.02628035
19protein deneddylation (GO:0000338)4.02575027
20guanosine-containing compound biosynthetic process (GO:1901070)3.97464350
21GTP biosynthetic process (GO:0006183)3.96265110
22rRNA modification (GO:0000154)3.95263743
23DNA strand elongation involved in DNA replication (GO:0006271)3.94288660
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.91232558
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.91149605
26L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.90480109
27maturation of SSU-rRNA (GO:0030490)3.88795741
28telomere maintenance via semi-conservative replication (GO:0032201)3.88595027
29deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.87350364
30DNA strand elongation (GO:0022616)3.82833535
31negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.82477281
32energy coupled proton transport, down electrochemical gradient (GO:0015985)3.80902484
33ATP synthesis coupled proton transport (GO:0015986)3.80902484
347-methylguanosine mRNA capping (GO:0006370)3.78418508
35pseudouridine synthesis (GO:0001522)3.75790518
36RNA capping (GO:0036260)3.75449894
377-methylguanosine RNA capping (GO:0009452)3.75449894
38left/right pattern formation (GO:0060972)3.75231400
39regulation of mitochondrial translation (GO:0070129)3.75210962
40electron transport chain (GO:0022900)3.74543138
41DNA replication checkpoint (GO:0000076)3.74316465
42negative regulation of T cell differentiation in thymus (GO:0033085)3.73183845
43positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.70831161
44intraciliary transport (GO:0042073)3.70796726
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.67450705
46UTP biosynthetic process (GO:0006228)3.66657862
47respiratory electron transport chain (GO:0022904)3.63079790
48CENP-A containing nucleosome assembly (GO:0034080)3.61211475
49anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.60683970
50ribosomal large subunit biogenesis (GO:0042273)3.59410202
51ribosome biogenesis (GO:0042254)3.57843250
52DNA replication initiation (GO:0006270)3.56501074
53chromatin remodeling at centromere (GO:0031055)3.52248632
54ribonucleoprotein complex biogenesis (GO:0022613)3.50087230
55protein complex biogenesis (GO:0070271)3.48456693
56formation of translation preinitiation complex (GO:0001731)3.42366101
57viral mRNA export from host cell nucleus (GO:0046784)3.41558283
58negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.41550390
59negative regulation of ligase activity (GO:0051352)3.41550390
60regulation of cellular amino acid metabolic process (GO:0006521)3.40796886
61respiratory chain complex IV assembly (GO:0008535)3.40209667
62L-fucose metabolic process (GO:0042354)3.39314703
63L-fucose catabolic process (GO:0042355)3.39314703
64fucose catabolic process (GO:0019317)3.39314703
65telomere maintenance via recombination (GO:0000722)3.39207625
66regulation of microtubule-based movement (GO:0060632)3.36024367
67mitotic metaphase plate congression (GO:0007080)3.35794862
68DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.35772993
69pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.35623715
70mitochondrial respiratory chain complex assembly (GO:0033108)3.35377238
71tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.35071116
72RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.35071116
73signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.34833200
74signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.34833200
75signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.34833200
76protein localization to cilium (GO:0061512)3.34479991
77transcription-coupled nucleotide-excision repair (GO:0006283)3.33116159
78amino acid salvage (GO:0043102)3.32826459
79L-methionine salvage (GO:0071267)3.32826459
80L-methionine biosynthetic process (GO:0071265)3.32826459
81mitochondrial respiratory chain complex I assembly (GO:0032981)3.32368542
82NADH dehydrogenase complex assembly (GO:0010257)3.32368542
83mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.32368542
84signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.32126667
85intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.32126667
86cellular component biogenesis (GO:0044085)3.32111281
87positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.31643670
88pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.30565647
89metallo-sulfur cluster assembly (GO:0031163)3.29140173
90iron-sulfur cluster assembly (GO:0016226)3.29140173
91rRNA processing (GO:0006364)3.28509033
92cilium organization (GO:0044782)3.28367799
93tRNA methylation (GO:0030488)3.28264755
94establishment of protein localization to mitochondrial membrane (GO:0090151)3.27969375
95nonmotile primary cilium assembly (GO:0035058)3.27638495
96exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.27362891
97rRNA methylation (GO:0031167)3.27052217
98ribosomal small subunit biogenesis (GO:0042274)3.25975573
99viral transcription (GO:0019083)3.25808617
100translation (GO:0006412)3.22731140
101cellular ketone body metabolic process (GO:0046950)3.22362526
102translational termination (GO:0006415)3.22005269
103cytochrome complex assembly (GO:0017004)3.21919817
104transcription elongation from RNA polymerase I promoter (GO:0006362)3.20727591
105signal transduction involved in DNA damage checkpoint (GO:0072422)3.20141112
106signal transduction involved in DNA integrity checkpoint (GO:0072401)3.20141112
107UTP metabolic process (GO:0046051)3.18931858
108signal transduction involved in cell cycle checkpoint (GO:0072395)3.18774943
109pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.18212272
110rRNA metabolic process (GO:0016072)3.17942134
111cilium assembly (GO:0042384)3.17685437
112nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.17115074
113positive regulation of ligase activity (GO:0051351)3.17043003
114pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.16961471
115negative regulation of telomere maintenance (GO:0032205)3.16542591
116termination of RNA polymerase I transcription (GO:0006363)3.15605364
117telomere maintenance via telomere lengthening (GO:0010833)3.15345866
118kinetochore assembly (GO:0051382)3.15253768
119CTP metabolic process (GO:0046036)3.13053497
120CTP biosynthetic process (GO:0006241)3.13053497
121chaperone-mediated protein transport (GO:0072321)3.12526431
122base-excision repair, AP site formation (GO:0006285)3.11729509
123SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.09680197
124histone exchange (GO:0043486)3.06470069
125translational elongation (GO:0006414)3.05073272
126deoxyribonucleotide biosynthetic process (GO:0009263)3.05031103
127transcription from RNA polymerase I promoter (GO:0006360)3.04781525
128cotranslational protein targeting to membrane (GO:0006613)3.03399432
129antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.03250102
130mitotic recombination (GO:0006312)3.02448509
131drug catabolic process (GO:0042737)2.95822588
132response to misfolded protein (GO:0051788)2.92337872
133purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.91893292
134ATP biosynthetic process (GO:0006754)2.91007985
135ketone body metabolic process (GO:1902224)2.90866381
136mannosylation (GO:0097502)2.88064815
137hydrogen ion transmembrane transport (GO:1902600)2.87565820
138purine nucleoside triphosphate biosynthetic process (GO:0009145)2.85995325
139microtubule bundle formation (GO:0001578)2.83457057
140synaptic transmission, cholinergic (GO:0007271)2.82814393
141protein targeting to ER (GO:0045047)2.81863874
142exogenous drug catabolic process (GO:0042738)2.78297608
143proton transport (GO:0015992)2.77878901
144protein polyglutamylation (GO:0018095)2.77470735
145preassembly of GPI anchor in ER membrane (GO:0016254)2.76902635
146phenol-containing compound catabolic process (GO:0019336)2.73687791
147left/right axis specification (GO:0070986)2.73074408
148protein localization to endoplasmic reticulum (GO:0070972)2.72944552
149protein-cofactor linkage (GO:0018065)2.72474197
150hydrogen transport (GO:0006818)2.70919472
151viral life cycle (GO:0019058)2.69841387
152cilium morphogenesis (GO:0060271)2.69701601
153aldehyde catabolic process (GO:0046185)2.68533951
154neurotransmitter catabolic process (GO:0042135)2.68210048
155cellular protein complex disassembly (GO:0043624)2.67577964
156establishment of protein localization to endoplasmic reticulum (GO:0072599)2.63565237
157piRNA metabolic process (GO:0034587)2.62146778
158DNA methylation involved in gamete generation (GO:0043046)2.59367830
159nucleoside diphosphate phosphorylation (GO:0006165)2.58029032
160positive regulation of fatty acid transport (GO:2000193)2.56988214
161protein insertion into membrane (GO:0051205)2.53795839
162cornea development in camera-type eye (GO:0061303)2.53302978
163positive regulation of prostaglandin secretion (GO:0032308)2.52390574
164platelet dense granule organization (GO:0060155)2.51940398
165ribonucleoside triphosphate biosynthetic process (GO:0009201)2.50252013
166alkaloid metabolic process (GO:0009820)2.49780963
167water-soluble vitamin biosynthetic process (GO:0042364)2.48345360
168glutathione derivative metabolic process (GO:1901685)2.47716260
169glutathione derivative biosynthetic process (GO:1901687)2.47716260
170kynurenine metabolic process (GO:0070189)2.46039855
171peptidyl-histidine modification (GO:0018202)2.45357113
172positive regulation of icosanoid secretion (GO:0032305)2.42677947
173nucleoside transmembrane transport (GO:1901642)2.42142563
174neurotransmitter metabolic process (GO:0042133)2.41495819
175fucosylation (GO:0036065)2.40293186
176GPI anchor metabolic process (GO:0006505)2.39541435

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.19235188
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.69354114
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.27015834
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.12082870
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.95293497
6* EST1_17652178_ChIP-ChIP_JURKAT_Human3.75587604
7* ETS1_20019798_ChIP-Seq_JURKAT_Human3.54211045
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.49095936
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.48403067
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.41121844
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.27164513
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.25965561
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.14226764
14EZH2_22144423_ChIP-Seq_EOC_Human3.03490927
15ZNF274_21170338_ChIP-Seq_K562_Hela2.99563565
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.87341332
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.83649980
18* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.80770019
19CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.77951820
20VDR_22108803_ChIP-Seq_LS180_Human2.68218436
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.63397947
22* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.56824231
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.56726198
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.56079923
25* VDR_23849224_ChIP-Seq_CD4+_Human2.55184491
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.54889213
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.50270278
28SRF_21415370_ChIP-Seq_HL-1_Mouse2.50076526
29YY1_21170310_ChIP-Seq_MESCs_Mouse2.37955813
30* DCP1A_22483619_ChIP-Seq_HELA_Human2.31758525
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.31699391
32* XRN2_22483619_ChIP-Seq_HELA_Human2.31366850
33* FOXP3_21729870_ChIP-Seq_TREG_Human2.22124275
34E2F1_18555785_ChIP-Seq_MESCs_Mouse2.21340142
35GABP_19822575_ChIP-Seq_HepG2_Human2.18620273
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.08002233
37NELFA_20434984_ChIP-Seq_ESCs_Mouse2.07507595
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.04643009
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.01837909
40TTF2_22483619_ChIP-Seq_HELA_Human1.98966399
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.91942654
42FOXM1_23109430_ChIP-Seq_U2OS_Human1.90009530
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.89506791
44ERA_21632823_ChIP-Seq_H3396_Human1.88666482
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.81915467
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77457758
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76917928
48* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76164746
49BCL6_27268052_Chip-Seq_Bcells_Human1.75358758
50E2F1_20622854_ChIP-Seq_HELA_Human1.75076640
51P68_20966046_ChIP-Seq_HELA_Human1.73909898
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.72036026
53PHF8_20622854_ChIP-Seq_HELA_Human1.69666702
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.68706114
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.68203325
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67448867
57* ELK1_19687146_ChIP-ChIP_HELA_Human1.63729378
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63460007
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63439291
60CTCF_20526341_ChIP-Seq_ESCs_Human1.62003018
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60954598
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58975349
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58765446
64CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.58035758
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.55027207
66TAF2_19829295_ChIP-Seq_ESCs_Human1.51037634
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.48975042
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48185214
69* CIITA_25753668_ChIP-Seq_RAJI_Human1.46419720
70GATA3_21878914_ChIP-Seq_MCF-7_Human1.45741907
71BCOR_27268052_Chip-Seq_Bcells_Human1.45031853
72SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.44792023
73CTCF_27219007_Chip-Seq_Bcells_Human1.42318324
74P300_27268052_Chip-Seq_Bcells_Human1.40603759
75CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39454818
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38502379
77EZH2_27294783_Chip-Seq_ESCs_Mouse1.36417534
78NANOG_20526341_ChIP-Seq_ESCs_Human1.34443050
79STAT1_20625510_ChIP-Seq_HELA_Human1.33817162
80TP53_22573176_ChIP-Seq_HFKS_Human1.33459393
81ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32376272
82MYC_19829295_ChIP-Seq_ESCs_Human1.32026747
83AR_21909140_ChIP-Seq_LNCAP_Human1.30706805
84ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30422070
85EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.30355346
86DROSHA_22980978_ChIP-Seq_HELA_Human1.30081208
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29061295
88OCT4_20526341_ChIP-Seq_ESCs_Human1.28629486
89P53_21459846_ChIP-Seq_SAOS-2_Human1.25675463
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25366327
91TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25339224
92BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25146492
93REST_21632747_ChIP-Seq_MESCs_Mouse1.23924387
94SA1_27219007_Chip-Seq_Bcells_Human1.22959149
95E2F1_21310950_ChIP-Seq_MCF-7_Human1.21248555
96ETV2_25802403_ChIP-Seq_MESCs_Mouse1.20672430
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.20492464
98CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20415282
99CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19810143
100MYC_18940864_ChIP-ChIP_HL60_Human1.19117660
101SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18323449
102AR_20517297_ChIP-Seq_VCAP_Human1.17997225
103PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17905709
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17671196
105NCOR_22424771_ChIP-Seq_293T_Human1.16848169
106RAC3_21632823_ChIP-Seq_H3396_Human1.15639412
107FOXA1_25329375_ChIP-Seq_VCAP_Human1.15599047
108FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15599047
109KDM5A_27292631_Chip-Seq_BREAST_Human1.14902422
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11839580
111TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10833229
112IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07891502
113PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07336661
114PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06947189
115CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06852844
116TDRD3_21172665_ChIP-Seq_MCF-7_Human1.06717306
117CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05573542
118SOX2_21211035_ChIP-Seq_LN229_Human1.04157107
119RAD21_21589869_ChIP-Seq_MESCs_Mouse1.03615159
120CTCF_26484167_Chip-Seq_Bcells_Mouse1.03050080
121E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02043920
122HOXB7_26014856_ChIP-Seq_BT474_Human1.01491579
123RARB_24833708_ChIP-Seq_LIVER_Mouse1.01211997
124BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01148229
125ELK1_22589737_ChIP-Seq_MCF10A_Human1.00693257
126CBX2_27304074_Chip-Seq_ESCs_Mouse1.00185507
127JARID2_20075857_ChIP-Seq_MESCs_Mouse0.99457882
128RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99413931
129SMC4_20622854_ChIP-Seq_HELA_Human0.98776943
130GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98055155
131SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97977346
132TP63_22573176_ChIP-Seq_HFKS_Human0.96712387
133CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96444527
134REST_18959480_ChIP-ChIP_MESCs_Mouse0.95766452
135HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94796986
136EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94454787
137P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.92812809
138* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91333088
139TP63_19390658_ChIP-ChIP_HaCaT_Human0.91257127
140IRF1_19129219_ChIP-ChIP_H3396_Human0.91152644
141* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89380909
142DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89272671
143YY1_22570637_ChIP-Seq_MALME-3M_Human0.89029103
144SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87998756
145KAP1_22055183_ChIP-Seq_ESCs_Mouse0.83171764
146DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83082717
147CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.81462435
148CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.80848936
149SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.79740571
150HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77982463
151TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77861798
152* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77027117
153SRY_22984422_ChIP-ChIP_TESTIS_Rat0.73307834
154RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.72647404
155* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72478884
156GATA3_21867929_ChIP-Seq_CD8_Mouse0.69300615
157TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.69159417
158KLF4_18555785_ChIP-Seq_MESCs_Mouse0.67856786
159TET1_21451524_ChIP-Seq_MESCs_Mouse0.66953842
160STAT3_1855785_ChIP-Seq_MESCs_Mouse0.65546650
161SPI1_23547873_ChIP-Seq_NB4_Human0.64938604
162* FOXP1_21924763_ChIP-Seq_HESCs_Human0.64188401

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.32029643
2MP0008058_abnormal_DNA_repair3.90957434
3MP0003111_abnormal_nucleus_morphology3.61747385
4MP0010094_abnormal_chromosome_stability3.45698615
5MP0008875_abnormal_xenobiotic_pharmacok3.39389459
6MP0004957_abnormal_blastocyst_morpholog3.33814627
7MP0008057_abnormal_DNA_replication3.26231353
8MP0003077_abnormal_cell_cycle3.04214050
9MP0006292_abnormal_olfactory_placode2.79960528
10MP0008932_abnormal_embryonic_tissue2.64225385
11MP0009379_abnormal_foot_pigmentation2.57517443
12MP0004043_abnormal_pH_regulation2.41403168
13MP0003786_premature_aging2.25215139
14MP0008007_abnormal_cellular_replicative2.07904194
15MP0005410_abnormal_fertilization2.01072722
16MP0008877_abnormal_DNA_methylation2.00456218
17MP0001968_abnormal_touch/_nociception1.98133562
18MP0001188_hyperpigmentation1.98048805
19MP0009697_abnormal_copulation1.93890717
20MP0003123_paternal_imprinting1.93784334
21MP0005551_abnormal_eye_electrophysiolog1.92799404
22MP0002132_abnormal_respiratory_system1.88343830
23MP0003718_maternal_effect1.87966021
24MP0008872_abnormal_physiological_respon1.87552966
25MP0003186_abnormal_redox_activity1.86950647
26MP0006036_abnormal_mitochondrial_physio1.86783534
27MP0002160_abnormal_reproductive_system1.83360226
28MP0002277_abnormal_respiratory_mucosa1.83183734
29MP0000015_abnormal_ear_pigmentation1.76200097
30MP0001529_abnormal_vocalization1.68127950
31MP0002102_abnormal_ear_morphology1.67698024
32MP0002653_abnormal_ependyma_morphology1.66633100
33MP0003136_yellow_coat_color1.66605242
34MP0001485_abnormal_pinna_reflex1.61290172
35MP0005075_abnormal_melanosome_morpholog1.59657075
36MP0004147_increased_porphyrin_level1.59051104
37MP0002210_abnormal_sex_determination1.58333523
38MP0001929_abnormal_gametogenesis1.56341259
39MP0006035_abnormal_mitochondrial_morpho1.55670498
40MP0003646_muscle_fatigue1.54449128
41MP0009745_abnormal_behavioral_response1.54239919
42MP0010030_abnormal_orbit_morphology1.53303650
43MP0004142_abnormal_muscle_tone1.49617490
44MP0002638_abnormal_pupillary_reflex1.46577724
45MP0000490_abnormal_crypts_of1.45956198
46MP0004145_abnormal_muscle_electrophysio1.45348651
47MP0005645_abnormal_hypothalamus_physiol1.42990488
48MP0001986_abnormal_taste_sensitivity1.42964824
49MP0003195_calcinosis1.40606148
50MP0002938_white_spotting1.40486657
51MP0004742_abnormal_vestibular_system1.40146994
52MP0009046_muscle_twitch1.39610399
53MP0001984_abnormal_olfaction1.38714101
54MP0002272_abnormal_nervous_system1.36363033
55MP0001145_abnormal_male_reproductive1.35447537
56MP0004885_abnormal_endolymph1.33616767
57MP0003698_abnormal_male_reproductive1.33539204
58MP0000566_synostosis1.33310535
59MP0005389_reproductive_system_phenotype1.32301186
60MP0005360_urolithiasis1.29567815
61MP0005394_taste/olfaction_phenotype1.29186446
62MP0005499_abnormal_olfactory_system1.29186446
63MP0002735_abnormal_chemical_nociception1.26937988
64MP0000631_abnormal_neuroendocrine_gland1.26466260
65MP0003880_abnormal_central_pattern1.25673451
66MP0002837_dystrophic_cardiac_calcinosis1.25066141
67MP0002396_abnormal_hematopoietic_system1.24158121
68MP0002249_abnormal_larynx_morphology1.24055825
69MP0001970_abnormal_pain_threshold1.21445982
70MP0002557_abnormal_social/conspecific_i1.21197566
71MP0003011_delayed_dark_adaptation1.18711920
72MP0001764_abnormal_homeostasis1.18585858
73MP0000678_abnormal_parathyroid_gland1.17595409
74MP0005174_abnormal_tail_pigmentation1.15959722
75MP0000653_abnormal_sex_gland1.15423386
76MP0002572_abnormal_emotion/affect_behav1.14901207
77MP0000026_abnormal_inner_ear1.14161484
78MP0005365_abnormal_bile_salt1.13329032
79MP0001730_embryonic_growth_arrest1.12953105
80MP0003315_abnormal_perineum_morphology1.12229400
81MP0002822_catalepsy1.11753208
82MP0002163_abnormal_gland_morphology1.11119686
83MP0000350_abnormal_cell_proliferation1.11041092
84MP0008789_abnormal_olfactory_epithelium1.09922345
85MP0002733_abnormal_thermal_nociception1.09571794
86MP0006072_abnormal_retinal_apoptosis1.08453147
87MP0005332_abnormal_amino_acid1.08040301
88MP0001502_abnormal_circadian_rhythm1.07971359
89MP0001293_anophthalmia1.07415203
90MP0003878_abnormal_ear_physiology1.07150282
91MP0005377_hearing/vestibular/ear_phenot1.07150282
92MP0000049_abnormal_middle_ear1.06679276
93MP0000313_abnormal_cell_death1.06608158
94MP0000427_abnormal_hair_cycle1.05669823
95MP0005083_abnormal_biliary_tract1.05347403
96MP0002064_seizures1.04231097
97MP0004133_heterotaxia1.03574933
98MP0008995_early_reproductive_senescence1.03124016
99MP0004019_abnormal_vitamin_homeostasis1.02486967
100MP0002909_abnormal_adrenal_gland1.00010632
101MP0000358_abnormal_cell_content/1.00005225
102MP0002095_abnormal_skin_pigmentation0.98645081
103MP0009333_abnormal_splenocyte_physiolog0.98429182
104MP0001919_abnormal_reproductive_system0.98222767
105MP0005253_abnormal_eye_physiology0.96427997
106MP0008004_abnormal_stomach_pH0.96377700
107MP0003787_abnormal_imprinting0.95874150
108MP0005646_abnormal_pituitary_gland0.95574534
109MP0003137_abnormal_impulse_conducting0.95443319
110MP0001501_abnormal_sleep_pattern0.95368289
111MP0000538_abnormal_urinary_bladder0.93303545
112MP0003806_abnormal_nucleotide_metabolis0.92635484
113MP0002282_abnormal_trachea_morphology0.92380766
114MP0005085_abnormal_gallbladder_physiolo0.92252554
115MP0002751_abnormal_autonomic_nervous0.91082309
116MP0001963_abnormal_hearing_physiology0.90992619
117MP0001664_abnormal_digestion0.90378361
118MP0001486_abnormal_startle_reflex0.90215643
119MP0005409_darkened_coat_color0.89287345
120MP0005084_abnormal_gallbladder_morpholo0.89071130
121MP0005423_abnormal_somatic_nervous0.88433430
122MP0002067_abnormal_sensory_capabilities0.88368287
123MP0000383_abnormal_hair_follicle0.86835163
124MP0000372_irregular_coat_pigmentation0.85478596
125MP0002234_abnormal_pharynx_morphology0.85084916
126MP0001119_abnormal_female_reproductive0.84632699
127MP0009643_abnormal_urine_homeostasis0.84021022
128MP0002752_abnormal_somatic_nervous0.83659039
129MP0001697_abnormal_embryo_size0.82527208
130MP0001672_abnormal_embryogenesis/_devel0.82251431
131MP0005380_embryogenesis_phenotype0.82251431
132MP0002080_prenatal_lethality0.80845019
133MP0008260_abnormal_autophagy0.80664369
134MP0003941_abnormal_skin_development0.80390934
135MP0002019_abnormal_tumor_incidence0.79511431
136MP0002876_abnormal_thyroid_physiology0.79470992
137MP0002161_abnormal_fertility/fecundity0.76801078
138MP0003938_abnormal_ear_development0.74833996
139MP0002736_abnormal_nociception_after0.70670359
140MP0003656_abnormal_erythrocyte_physiolo0.69504181
141MP0003984_embryonic_growth_retardation0.69371939
142MP0003567_abnormal_fetal_cardiomyocyte0.69197526
143MP0006276_abnormal_autonomic_nervous0.69095006
144MP0003763_abnormal_thymus_physiology0.68267697
145MP0005397_hematopoietic_system_phenotyp0.66954840
146MP0001545_abnormal_hematopoietic_system0.66954840
147MP0002085_abnormal_embryonic_tissue0.66491567
148MP0000749_muscle_degeneration0.66277145
149MP0003890_abnormal_embryonic-extraembry0.65294926
150MP0001905_abnormal_dopamine_level0.63424258
151MP0002088_abnormal_embryonic_growth/wei0.62997783
152MP0005636_abnormal_mineral_homeostasis0.62516888
153MP0003121_genomic_imprinting0.59408493

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.19084308
2Mitochondrial inheritance (HP:0001427)3.83731150
3Abnormal number of erythroid precursors (HP:0012131)3.82341983
4Acute necrotizing encephalopathy (HP:0006965)3.80687978
5Abnormality of cells of the erythroid lineage (HP:0012130)3.76646060
6Nephronophthisis (HP:0000090)3.68894229
7Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.67529222
8Hepatocellular necrosis (HP:0001404)3.64339622
9Increased CSF lactate (HP:0002490)3.62772483
10Decreased activity of mitochondrial respiratory chain (HP:0008972)3.62696688
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.62696688
12Increased hepatocellular lipid droplets (HP:0006565)3.62201391
13Abnormal mitochondria in muscle tissue (HP:0008316)3.61036763
14Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.47504162
15Increased serum lactate (HP:0002151)3.43763794
16Hepatic necrosis (HP:0002605)3.41614852
17Type I transferrin isoform profile (HP:0003642)3.39435216
18Lipid accumulation in hepatocytes (HP:0006561)3.30291168
19Aplastic anemia (HP:0001915)3.27592424
20Birth length less than 3rd percentile (HP:0003561)3.22979490
21Abnormal respiratory epithelium morphology (HP:0012253)3.22655639
22Abnormal respiratory motile cilium morphology (HP:0005938)3.22655639
23Renal Fanconi syndrome (HP:0001994)3.20413120
24Acute encephalopathy (HP:0006846)3.12401717
25Bronchiectasis (HP:0002110)3.12167005
26Exertional dyspnea (HP:0002875)3.09082946
27Type II lissencephaly (HP:0007260)3.08625395
28Cystic liver disease (HP:0006706)3.07379235
29Reticulocytopenia (HP:0001896)3.02480506
30Abnormality of the renal medulla (HP:0100957)2.96784274
31Progressive macrocephaly (HP:0004481)2.93753343
32Exercise intolerance (HP:0003546)2.92166010
33Chronic bronchitis (HP:0004469)2.91627508
343-Methylglutaconic aciduria (HP:0003535)2.87291935
35Aplasia/Hypoplasia of the sacrum (HP:0008517)2.84294821
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.83659083
37Lactic acidosis (HP:0003128)2.82622402
38Absent/shortened dynein arms (HP:0200106)2.82067521
39Dynein arm defect of respiratory motile cilia (HP:0012255)2.82067521
40Abnormal respiratory motile cilium physiology (HP:0012261)2.78474548
41Pancreatic fibrosis (HP:0100732)2.78325721
42Increased intramyocellular lipid droplets (HP:0012240)2.77052552
43Occipital encephalocele (HP:0002085)2.76339168
44Sclerocornea (HP:0000647)2.74498026
45Tubular atrophy (HP:0000092)2.72663954
46Cerebral hypomyelination (HP:0006808)2.66992096
47Respiratory difficulties (HP:0002880)2.64933196
48Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.61748945
49Abnormal protein N-linked glycosylation (HP:0012347)2.61748945
50Abnormal protein glycosylation (HP:0012346)2.61748945
51Abnormal glycosylation (HP:0012345)2.61748945
52Chronic hepatic failure (HP:0100626)2.57363545
53Rough bone trabeculation (HP:0100670)2.54109401
54Reduced antithrombin III activity (HP:0001976)2.53843136
55Abnormality of the preputium (HP:0100587)2.53716159
56Chromsome breakage (HP:0040012)2.53465484
57Degeneration of anterior horn cells (HP:0002398)2.53321323
58Abnormality of the anterior horn cell (HP:0006802)2.53321323
59Concave nail (HP:0001598)2.52076560
60True hermaphroditism (HP:0010459)2.51597193
61Oral leukoplakia (HP:0002745)2.51260646
62Rhinitis (HP:0012384)2.48901238
63Retinal dysplasia (HP:0007973)2.47887739
64Abnormality of renal resorption (HP:0011038)2.47429851
65Meckel diverticulum (HP:0002245)2.43582078
66Gait imbalance (HP:0002141)2.43411993
67Microvesicular hepatic steatosis (HP:0001414)2.42689572
68Pancreatic cysts (HP:0001737)2.41143147
69Congenital stationary night blindness (HP:0007642)2.40186776
70Abnormality of the renal cortex (HP:0011035)2.37944886
71Increased muscle lipid content (HP:0009058)2.36864356
72Macrocytic anemia (HP:0001972)2.36825209
73Congenital primary aphakia (HP:0007707)2.34538801
74Nasal polyposis (HP:0100582)2.34357776
75Abnormality of the ileum (HP:0001549)2.32236633
76Postaxial foot polydactyly (HP:0001830)2.31566058
77Congenital hepatic fibrosis (HP:0002612)2.29056495
78Abnormal ciliary motility (HP:0012262)2.26634343
79Male pseudohermaphroditism (HP:0000037)2.25082284
80Abnormal drinking behavior (HP:0030082)2.24405699
81Polydipsia (HP:0001959)2.24405699
82Aplasia/Hypoplasia of the uvula (HP:0010293)2.20678816
83Breast hypoplasia (HP:0003187)2.19506396
84Nephrogenic diabetes insipidus (HP:0009806)2.19491830
85Supernumerary spleens (HP:0009799)2.17893092
86Chronic sinusitis (HP:0011109)2.16358432
87Respiratory failure (HP:0002878)2.15886279
88Pallor (HP:0000980)2.15348831
89Abnormality of glycolysis (HP:0004366)2.15196848
90Increased serum pyruvate (HP:0003542)2.15196848
91Carpal bone hypoplasia (HP:0001498)2.15030678
92Type 2 muscle fiber atrophy (HP:0003554)2.14201593
93Severe visual impairment (HP:0001141)2.13718433
94Infertility (HP:0000789)2.13612235
95Microretrognathia (HP:0000308)2.13054926
96Pancytopenia (HP:0001876)2.12463271
97Bone marrow hypocellularity (HP:0005528)2.11866234
98Decreased circulating renin level (HP:0003351)2.10318639
99Severe muscular hypotonia (HP:0006829)2.08010580
100Furrowed tongue (HP:0000221)2.06363538
101Abnormal rod and cone electroretinograms (HP:0008323)2.05967285
102Unsteady gait (HP:0002317)2.04689227
103Aplasia/Hypoplasia of the tongue (HP:0010295)2.04125782
104Cerebral edema (HP:0002181)2.02875141
105Facial cleft (HP:0002006)2.02458478
106Absent thumb (HP:0009777)1.98490860
107Optic disc pallor (HP:0000543)1.96969364
108Abnormal biliary tract physiology (HP:0012439)1.96320343
109Bile duct proliferation (HP:0001408)1.96320343
110Hyperglycinuria (HP:0003108)1.95984368
111Irregular epiphyses (HP:0010582)1.95844272
112Patellar aplasia (HP:0006443)1.94866862
113Abnormality of alanine metabolism (HP:0010916)1.94285553
114Hyperalaninemia (HP:0003348)1.94285553
115Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94285553
116Abnormal lung lobation (HP:0002101)1.93026736
11711 pairs of ribs (HP:0000878)1.90992930
118Anencephaly (HP:0002323)1.90506760
119Generalized aminoaciduria (HP:0002909)1.89884573
120Premature graying of hair (HP:0002216)1.89042378
121Polyuria (HP:0000103)1.88564427
122Aplasia/Hypoplasia of the spleen (HP:0010451)1.87549288
123Rib fusion (HP:0000902)1.87447424
124Muscle fiber atrophy (HP:0100295)1.87366903
125Optic nerve coloboma (HP:0000588)1.86431976
126Large for gestational age (HP:0001520)1.86218396
127Lissencephaly (HP:0001339)1.85998200
128Lethargy (HP:0001254)1.85843617
129Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85733519
130Impulsivity (HP:0100710)1.84549421
131Progressive microcephaly (HP:0000253)1.82878220
132Cleft eyelid (HP:0000625)1.82379312
133Abnormality of chromosome stability (HP:0003220)1.82344477
134CNS demyelination (HP:0007305)1.82096936
135Aplasia/Hypoplasia of the patella (HP:0006498)1.82042211
136Triphalangeal thumb (HP:0001199)1.82013137
137Medial flaring of the eyebrow (HP:0010747)1.81154789
138Abolished electroretinogram (ERG) (HP:0000550)1.80837891
139Abnormal trabecular bone morphology (HP:0100671)1.80338761
140Abnormality of midbrain morphology (HP:0002418)1.79747668
141Molar tooth sign on MRI (HP:0002419)1.79747668
142Cerebellar dysplasia (HP:0007033)1.79600585
143Abnormality of the heme biosynthetic pathway (HP:0010472)1.78913181
144Congenital, generalized hypertrichosis (HP:0004540)1.77386336
145Decreased central vision (HP:0007663)1.73335597
146Abnormality of the nasal mucosa (HP:0000433)1.73008609
147Asplenia (HP:0001746)1.72205853
148Oculomotor apraxia (HP:0000657)1.71265745
149Pendular nystagmus (HP:0012043)1.69388651
150Aganglionic megacolon (HP:0002251)1.69242739
151Postaxial hand polydactyly (HP:0001162)1.67939974
152Preaxial hand polydactyly (HP:0001177)1.67395990
153Retinitis pigmentosa (HP:0000510)1.66991478
154Tubulointerstitial nephritis (HP:0001970)1.66626944

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.52759326
2STK164.49575675
3WEE13.52389753
4VRK23.21831767
5EIF2AK13.17519777
6FRK2.64988972
7NME22.53887606
8WNK42.51936388
9VRK12.49362840
10PIM22.47081368
11SRPK12.40628114
12EIF2AK32.40272777
13CDC72.23049130
14MAP4K22.19052710
15MAPKAPK32.18786065
16BRSK22.11499367
17CCNB12.09366893
18BRAF2.02254437
19PLK42.01142430
20ZAK1.98724314
21BCKDK1.96091403
22DYRK31.72950956
23WNK31.72327344
24TSSK61.71765165
25TLK11.70087450
26INSRR1.69804336
27PLK11.62889778
28NUAK11.61861213
29NME11.54900125
30PRPF4B1.47991677
31PLK31.41447149
32MKNK11.40754287
33MKNK21.39803588
34BRSK11.37780773
35CDK81.34849496
36ADRBK11.32491866
37CDK71.32192603
38TAOK21.31727374
39MAP2K21.31279066
40PRKD31.27045082
41STK38L1.23654841
42AURKA1.23361231
43DYRK21.22341207
44TTK1.21605968
45NTRK31.19187993
46ACVR1B1.17758854
47TESK21.17158394
48PDK41.14392385
49PDK31.14392385
50TESK11.13581168
51MAP2K71.13123979
52EIF2AK21.12254404
53ATR1.11364838
54AURKB1.11108740
55CSNK1G31.07256463
56TAOK31.06379588
57ADRBK21.05945638
58YES11.05085905
59LIMK11.03780286
60CHEK21.03462045
61CASK1.03259884
62MAPKAPK51.01377161
63MAP3K41.01039297
64OXSR11.00753824
65CSNK1G21.00521684
66MAP3K120.99676956
67MAP3K110.98698793
68RPS6KA40.98541016
69IRAK30.97804216
70ARAF0.95991518
71NEK10.93530963
72AKT30.92811392
73MST40.87877103
74PASK0.83812347
75PINK10.83789575
76DAPK20.81248347
77NEK20.79881538
78CAMKK10.77149244
79CDK190.76394070
80CSNK1A1L0.76315355
81STK390.73878132
82PTK2B0.71953320
83TXK0.71755640
84MUSK0.71038533
85DAPK10.70989582
86PDK20.70440944
87CSNK2A10.70315606
88KDR0.69961845
89IRAK40.68599647
90CSNK1G10.68537920
91TEC0.66832827
92BMPR20.66146587
93GRK60.65959236
94PHKG10.65531460
95PHKG20.65531460
96BMPR1B0.65011538
97ABL20.64366902
98PAK10.64177807
99MARK10.63499006
100PKN10.62670644
101PRKCI0.62659760
102MYLK0.61455107
103MAP2K40.60492039
104OBSCN0.59812677
105ERBB30.57374478
106PAK30.55857777
107CSNK2A20.55462609
108PNCK0.55103874
109PRKACA0.53989987
110EPHA40.53895050
111MAP2K60.51825816
112PRKCQ0.51706803
113CHEK10.51009416
114TNK20.50947680
115BLK0.49752037
116PIK3CG0.48642238
117STK110.48561901
118PIK3CA0.48196786
119STK240.47063422
120RPS6KA60.46304624
121IKBKB0.45342726
122CAMK2A0.45020514
123ERBB20.44624823
124TAF10.44315424
125RPS6KA50.43610760
126PRKCZ0.42522871
127CSNK1A10.41885114
128ILK0.41519102
129PRKCE0.41283312
130PRKCA0.41065544
131MAP3K50.40440881
132PBK0.40166406
133PIM10.40035039
134GRK10.38617640
135MAPK150.37704460
136TGFBR10.36980217
137CAMKK20.34847999
138SIK30.34526604
139SCYL20.34428140
140LRRK20.33671459
141PRKCG0.33488723
142MAPK130.32892448
143CAMK10.32887540
144BTK0.32785993
145MAP3K60.32543663
146PAK40.32170642
147MINK10.31723907
148ATM0.31151114
149TIE10.30840527
150EPHA20.30160016
151CDK20.29947809
152AKT20.29878274
153MAP3K80.28630219

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.18582576
2DNA replication_Homo sapiens_hsa030304.09491994
3RNA polymerase_Homo sapiens_hsa030203.94392593
4Ribosome_Homo sapiens_hsa030103.90840415
5Mismatch repair_Homo sapiens_hsa034303.36715032
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.10278991
7Homologous recombination_Homo sapiens_hsa034402.97661831
8Pyrimidine metabolism_Homo sapiens_hsa002402.90295020
9Oxidative phosphorylation_Homo sapiens_hsa001902.77782395
10Base excision repair_Homo sapiens_hsa034102.70277533
11Spliceosome_Homo sapiens_hsa030402.54691838
12Parkinsons disease_Homo sapiens_hsa050122.51388850
13Nucleotide excision repair_Homo sapiens_hsa034202.37220196
14RNA transport_Homo sapiens_hsa030132.31645754
15Huntingtons disease_Homo sapiens_hsa050162.26142915
16Fanconi anemia pathway_Homo sapiens_hsa034602.18022940
17Protein export_Homo sapiens_hsa030602.03149353
18Basal transcription factors_Homo sapiens_hsa030222.00760260
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.95982164
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95939738
21Purine metabolism_Homo sapiens_hsa002301.87257846
22Butanoate metabolism_Homo sapiens_hsa006501.81965960
23Cell cycle_Homo sapiens_hsa041101.79410122
24Nitrogen metabolism_Homo sapiens_hsa009101.76707667
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.75255922
26One carbon pool by folate_Homo sapiens_hsa006701.65624551
27RNA degradation_Homo sapiens_hsa030181.60212372
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.59197373
29Phototransduction_Homo sapiens_hsa047441.57485453
30Alzheimers disease_Homo sapiens_hsa050101.54891615
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54154551
32Tyrosine metabolism_Homo sapiens_hsa003501.45755178
33Caffeine metabolism_Homo sapiens_hsa002321.43168938
34Histidine metabolism_Homo sapiens_hsa003401.34247303
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32197905
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.31808923
37Tryptophan metabolism_Homo sapiens_hsa003801.27759122
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27429823
39Vitamin B6 metabolism_Homo sapiens_hsa007501.17093429
40Pentose phosphate pathway_Homo sapiens_hsa000301.16235012
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15887937
42Non-homologous end-joining_Homo sapiens_hsa034501.15296530
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.14186032
44Ether lipid metabolism_Homo sapiens_hsa005651.13870162
45Nicotine addiction_Homo sapiens_hsa050331.13733065
46Fat digestion and absorption_Homo sapiens_hsa049751.13706355
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.09079051
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07420874
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07301252
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06545094
51Primary bile acid biosynthesis_Homo sapiens_hsa001201.05989905
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04252732
53Folate biosynthesis_Homo sapiens_hsa007900.99463483
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.99163716
55Glutathione metabolism_Homo sapiens_hsa004800.96199994
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95580830
57Arachidonic acid metabolism_Homo sapiens_hsa005900.94849550
58Cardiac muscle contraction_Homo sapiens_hsa042600.94703786
59Sulfur relay system_Homo sapiens_hsa041220.92123035
60Sulfur metabolism_Homo sapiens_hsa009200.85507194
61Epstein-Barr virus infection_Homo sapiens_hsa051690.85124265
62Fructose and mannose metabolism_Homo sapiens_hsa000510.84522858
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.81189136
64Metabolic pathways_Homo sapiens_hsa011000.80395540
65p53 signaling pathway_Homo sapiens_hsa041150.79556702
66Regulation of autophagy_Homo sapiens_hsa041400.79019850
67Biosynthesis of amino acids_Homo sapiens_hsa012300.77648968
68mRNA surveillance pathway_Homo sapiens_hsa030150.76529514
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75742043
70Taste transduction_Homo sapiens_hsa047420.71092858
71Fatty acid degradation_Homo sapiens_hsa000710.71091611
72Carbon metabolism_Homo sapiens_hsa012000.70028343
73Olfactory transduction_Homo sapiens_hsa047400.68893791
74Steroid biosynthesis_Homo sapiens_hsa001000.68030464
75ABC transporters_Homo sapiens_hsa020100.67719527
76N-Glycan biosynthesis_Homo sapiens_hsa005100.66957874
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.66320174
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65589970
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63596099
80Galactose metabolism_Homo sapiens_hsa000520.60929646
81Linoleic acid metabolism_Homo sapiens_hsa005910.58951139
82Glycerolipid metabolism_Homo sapiens_hsa005610.56357088
83Asthma_Homo sapiens_hsa053100.56146752
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55710291
85Ovarian steroidogenesis_Homo sapiens_hsa049130.51147289
86Arginine biosynthesis_Homo sapiens_hsa002200.50422479
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49204982
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47961529
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47579068
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47549929
91Morphine addiction_Homo sapiens_hsa050320.46297482
92Serotonergic synapse_Homo sapiens_hsa047260.46176278
93Mineral absorption_Homo sapiens_hsa049780.45536588
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44956545
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.44494237
96Herpes simplex infection_Homo sapiens_hsa051680.44277586
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43942687
98Selenocompound metabolism_Homo sapiens_hsa004500.43825896
99Other glycan degradation_Homo sapiens_hsa005110.41365400
100Systemic lupus erythematosus_Homo sapiens_hsa053220.40904620
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40854902
102Pyruvate metabolism_Homo sapiens_hsa006200.40241194
103Vitamin digestion and absorption_Homo sapiens_hsa049770.38969993
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38516815
105Insulin secretion_Homo sapiens_hsa049110.38074567
106Oocyte meiosis_Homo sapiens_hsa041140.37795807
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37379586
108Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36975958
109Propanoate metabolism_Homo sapiens_hsa006400.36420860
110Legionellosis_Homo sapiens_hsa051340.35270735
111Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.32554577
112Sphingolipid metabolism_Homo sapiens_hsa006000.31805726
113Salivary secretion_Homo sapiens_hsa049700.30060007
114Fatty acid metabolism_Homo sapiens_hsa012120.29607820
115GABAergic synapse_Homo sapiens_hsa047270.29490748
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24683818
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23459526
118Arginine and proline metabolism_Homo sapiens_hsa003300.23316970
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22190065
120Collecting duct acid secretion_Homo sapiens_hsa049660.21302773
121Peroxisome_Homo sapiens_hsa041460.21226013
122Retinol metabolism_Homo sapiens_hsa008300.20562405
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18433537
124Fatty acid elongation_Homo sapiens_hsa000620.16403670
125Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.16201785
126Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.14574491
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14183830
128Thyroid cancer_Homo sapiens_hsa052160.14040646
129Starch and sucrose metabolism_Homo sapiens_hsa005000.13230368
130Chemical carcinogenesis_Homo sapiens_hsa052040.12698238
131Steroid hormone biosynthesis_Homo sapiens_hsa001400.11768550
132beta-Alanine metabolism_Homo sapiens_hsa004100.11193654
133Renin-angiotensin system_Homo sapiens_hsa046140.11097971
134Allograft rejection_Homo sapiens_hsa053300.10423146
135HTLV-I infection_Homo sapiens_hsa051660.09868163
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.09339310
137Phenylalanine metabolism_Homo sapiens_hsa003600.08789647
138Viral carcinogenesis_Homo sapiens_hsa052030.08754259
139Vibrio cholerae infection_Homo sapiens_hsa051100.07665782

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