COQ6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the ubiH/COQ6 family. It is an evolutionarily conserved monooxygenase required for the biosynthesis of coenzyme Q10 (or ubiquinone), which is an essential component of the mitochondrial electron transport chain, and one of the most potent lipophilic antioxidants implicated in the protection of cell damage by reactive oxygen species. Knockdown of this gene in mouse and zebrafish results in decreased growth due to increased apoptosis. Mutations in this gene are associated with autosomal recessive coenzyme Q10 deficiency-6 (COQ10D6), which manifests as nephrotic syndrome with sensorineural deafness. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.79854717
2behavioral response to nicotine (GO:0035095)5.56550269
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.24482627
4ATP synthesis coupled proton transport (GO:0015986)5.24482627
5ribosomal small subunit assembly (GO:0000028)4.85469367
6maturation of SSU-rRNA (GO:0030490)4.84604057
7tricarboxylic acid cycle (GO:0006099)4.76725606
8oxidative phosphorylation (GO:0006119)4.70776881
9fucose catabolic process (GO:0019317)4.68763168
10L-fucose metabolic process (GO:0042354)4.68763168
11L-fucose catabolic process (GO:0042355)4.68763168
12viral transcription (GO:0019083)4.29641372
13translational termination (GO:0006415)4.20442314
14piRNA metabolic process (GO:0034587)4.19488238
15formation of translation preinitiation complex (GO:0001731)4.16420794
16NADH metabolic process (GO:0006734)4.15078996
17ribosomal small subunit biogenesis (GO:0042274)4.12529313
18water-soluble vitamin biosynthetic process (GO:0042364)4.05882212
19respiratory electron transport chain (GO:0022904)4.02828435
20DNA strand elongation involved in DNA replication (GO:0006271)3.99476010
21proteasome assembly (GO:0043248)3.98575102
22translational elongation (GO:0006414)3.94422148
23electron transport chain (GO:0022900)3.94006067
24cellular ketone body metabolic process (GO:0046950)3.91258089
25DNA deamination (GO:0045006)3.91047716
26purine nucleobase biosynthetic process (GO:0009113)3.87782911
27mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.84806206
28nucleobase biosynthetic process (GO:0046112)3.81149880
29telomere maintenance via semi-conservative replication (GO:0032201)3.80346786
30indolalkylamine metabolic process (GO:0006586)3.79455028
31DNA strand elongation (GO:0022616)3.78826965
32ribosomal large subunit biogenesis (GO:0042273)3.77459023
33DNA replication initiation (GO:0006270)3.60853915
34translational initiation (GO:0006413)3.60569614
35regulation of mitochondrial translation (GO:0070129)3.58824615
36kynurenine metabolic process (GO:0070189)3.58650135
37epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.55401407
38tryptophan catabolic process (GO:0006569)3.54344429
39indole-containing compound catabolic process (GO:0042436)3.54344429
40indolalkylamine catabolic process (GO:0046218)3.54344429
41mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.54182689
42mitochondrial respiratory chain complex I assembly (GO:0032981)3.54182689
43NADH dehydrogenase complex assembly (GO:0010257)3.54182689
44DNA replication checkpoint (GO:0000076)3.53387312
45negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.52147901
46rRNA modification (GO:0000154)3.51803300
47SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.49623705
48ketone body metabolic process (GO:1902224)3.48821971
49tryptophan metabolic process (GO:0006568)3.47822357
50cotranslational protein targeting to membrane (GO:0006613)3.46040112
51DNA unwinding involved in DNA replication (GO:0006268)3.43564672
52protein targeting to ER (GO:0045047)3.40368479
53positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.39809356
54spliceosomal snRNP assembly (GO:0000387)3.39250285
55* quinone biosynthetic process (GO:1901663)3.38672571
56* ubiquinone biosynthetic process (GO:0006744)3.38672571
57ribonucleoprotein complex biogenesis (GO:0022613)3.37867851
58nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.37456685
59regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.36817541
60dopamine transport (GO:0015872)3.36587725
61regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.35087833
62anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.34743720
63negative regulation of telomere maintenance (GO:0032205)3.34656668
64mitochondrial respiratory chain complex assembly (GO:0033108)3.33892159
65viral life cycle (GO:0019058)3.30791864
66cellular protein complex disassembly (GO:0043624)3.30695290
67protein deneddylation (GO:0000338)3.30471624
68nonmotile primary cilium assembly (GO:0035058)3.30239445
69cellular component biogenesis (GO:0044085)3.29084015
70telomere maintenance via recombination (GO:0000722)3.28467373
71translation (GO:0006412)3.27203271
72L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.27176495
73establishment of protein localization to endoplasmic reticulum (GO:0072599)3.27074427
74protein complex biogenesis (GO:0070271)3.25438161
75DNA methylation involved in gamete generation (GO:0043046)3.25118911
76negative regulation of ligase activity (GO:0051352)3.24891219
77negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.24891219
78respiratory chain complex IV assembly (GO:0008535)3.22967421
79protein localization to endoplasmic reticulum (GO:0070972)3.22658771
80protein polyglutamylation (GO:0018095)3.21867922
81regulation of cilium movement (GO:0003352)3.21755680
82platelet dense granule organization (GO:0060155)3.20663983
83RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.19685309
84tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.19685309
85pseudouridine synthesis (GO:0001522)3.13521291
86IMP biosynthetic process (GO:0006188)3.12849770
87cornea development in camera-type eye (GO:0061303)3.11902933
88deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.11091844
89CENP-A containing nucleosome assembly (GO:0034080)3.10530026
90sarcomere organization (GO:0045214)3.10405467
91mitotic recombination (GO:0006312)3.09238416
92DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.08926980
93regulation of cellular amino acid metabolic process (GO:0006521)3.08551077
94detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.07935355
95rRNA processing (GO:0006364)3.07737803
96cellular biogenic amine catabolic process (GO:0042402)3.07631306
97amine catabolic process (GO:0009310)3.07631306
98protein-cofactor linkage (GO:0018065)3.06434498
99detection of light stimulus involved in sensory perception (GO:0050962)3.06058531
100detection of light stimulus involved in visual perception (GO:0050908)3.06058531
101chromatin remodeling at centromere (GO:0031055)3.06049936
102regulation of acyl-CoA biosynthetic process (GO:0050812)3.05979430
103tRNA methylation (GO:0030488)3.05752374
104chaperone-mediated protein transport (GO:0072321)3.05176173
105epithelial cilium movement (GO:0003351)3.04930500
106termination of RNA polymerase III transcription (GO:0006386)3.04036247
107transcription elongation from RNA polymerase III promoter (GO:0006385)3.04036247
108inner mitochondrial membrane organization (GO:0007007)3.03291152
109ribosome biogenesis (GO:0042254)3.01484438
110signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.01232316
111intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.01232316
112telomere maintenance via telomere lengthening (GO:0010833)2.98996264
113signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.98935554
114signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.98935554
115signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.98935554
116kinetochore assembly (GO:0051382)2.98662134
117rRNA methylation (GO:0031167)2.97952036
118indole-containing compound metabolic process (GO:0042430)2.97745682
119mannosylation (GO:0097502)2.97410570
120response to pheromone (GO:0019236)2.96761257
121establishment of protein localization to mitochondrial membrane (GO:0090151)2.96674185
122axoneme assembly (GO:0035082)2.95671749
123IMP metabolic process (GO:0046040)2.95664865
124establishment of integrated proviral latency (GO:0075713)2.95404717
125signal transduction involved in DNA damage checkpoint (GO:0072422)2.95247737
126signal transduction involved in DNA integrity checkpoint (GO:0072401)2.95247737
127* ubiquinone metabolic process (GO:0006743)2.95209644
128heart process (GO:0003015)2.94301435
129heart contraction (GO:0060047)2.94301435
130rRNA metabolic process (GO:0016072)2.94266332
131positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.94112425
132regulation of cofactor metabolic process (GO:0051193)2.93136979
133regulation of coenzyme metabolic process (GO:0051196)2.93136979
134ATP biosynthetic process (GO:0006754)2.92756213
135cullin deneddylation (GO:0010388)2.92684362
136protein complex disassembly (GO:0043241)2.92015845
137signal transduction involved in cell cycle checkpoint (GO:0072395)2.91585551
138preassembly of GPI anchor in ER membrane (GO:0016254)2.86624926
139aldehyde catabolic process (GO:0046185)2.82016059
140negative regulation of reactive oxygen species metabolic process (GO:2000378)2.81525420
141intraciliary transport (GO:0042073)2.80737774
142synaptic transmission, cholinergic (GO:0007271)2.79381874
143negative regulation of synaptic transmission, GABAergic (GO:0032229)2.77661416
144primary amino compound metabolic process (GO:1901160)2.77315148
145cytochrome complex assembly (GO:0017004)2.77186176
146aspartate family amino acid catabolic process (GO:0009068)2.74424424
147glyoxylate metabolic process (GO:0046487)2.72133319
148neuronal action potential (GO:0019228)2.72111434
149L-methionine salvage (GO:0071267)2.71454866
150L-methionine biosynthetic process (GO:0071265)2.71454866
151amino acid salvage (GO:0043102)2.71454866
152alanine transport (GO:0032328)2.70910736
153gamma-aminobutyric acid transport (GO:0015812)2.70605419
154behavioral response to ethanol (GO:0048149)2.67065889
155sulfation (GO:0051923)2.66454468
156regulation of glucokinase activity (GO:0033131)2.65527361
157regulation of hexokinase activity (GO:1903299)2.65527361
158cilium morphogenesis (GO:0060271)2.61994043
159S-adenosylmethionine metabolic process (GO:0046500)2.61258390
160cilium organization (GO:0044782)2.60902016
161retinal cone cell development (GO:0046549)2.59147105
162reflex (GO:0060004)2.58298965
163branched-chain amino acid catabolic process (GO:0009083)2.57893182
164regulation of microtubule-based movement (GO:0060632)2.55822426
165nephron epithelium morphogenesis (GO:0072088)2.54928491
166nephron tubule morphogenesis (GO:0072078)2.54928491
167regulation of action potential (GO:0098900)2.54408998
168cilium assembly (GO:0042384)2.53329272
169GPI anchor metabolic process (GO:0006505)2.51287842
170reciprocal DNA recombination (GO:0035825)2.50242584
171reciprocal meiotic recombination (GO:0007131)2.50242584
172protein import into peroxisome matrix (GO:0016558)2.47635258
173pyrimidine nucleobase catabolic process (GO:0006208)2.47120181
174replication fork processing (GO:0031297)2.46298378
175serotonin metabolic process (GO:0042428)2.45121037
176auditory receptor cell stereocilium organization (GO:0060088)2.45020179
177cilium movement (GO:0003341)2.44693180
178fucosylation (GO:0036065)2.43184944
179sperm motility (GO:0030317)2.42883644
180multicellular organism reproduction (GO:0032504)2.41953584
181male meiosis I (GO:0007141)2.41543176
182lysine catabolic process (GO:0006554)2.40858155
183lysine metabolic process (GO:0006553)2.40858155

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.35747974
2ZNF274_21170338_ChIP-Seq_K562_Hela4.64725746
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.37038274
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.21289563
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.11215760
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.65100392
7VDR_22108803_ChIP-Seq_LS180_Human3.57267172
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.44394391
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.40419067
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.39320183
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.26393277
12MYC_18358816_ChIP-ChIP_MESCs_Mouse3.20917580
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.17888115
14CREB1_15753290_ChIP-ChIP_HEK293T_Human3.13156249
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.99533555
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.87293783
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.86668386
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.77357743
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.73560078
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.71790103
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.64451224
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.56225085
23GBX2_23144817_ChIP-Seq_PC3_Human2.53905622
24EZH2_22144423_ChIP-Seq_EOC_Human2.52776273
25IGF1R_20145208_ChIP-Seq_DFB_Human2.52364911
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.42369534
27XRN2_22483619_ChIP-Seq_HELA_Human2.40489961
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.37533550
29ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35133321
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.31500599
31NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29361460
32THAP11_20581084_ChIP-Seq_MESCs_Mouse2.25631500
33SRF_21415370_ChIP-Seq_HL-1_Mouse2.25512599
34ELF1_17652178_ChIP-ChIP_JURKAT_Human2.24284292
35VDR_23849224_ChIP-Seq_CD4+_Human2.23370734
36YY1_21170310_ChIP-Seq_MESCs_Mouse2.20203136
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.17027128
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13471846
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.12924560
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.12919610
41DCP1A_22483619_ChIP-Seq_HELA_Human2.12841147
42FOXP3_21729870_ChIP-Seq_TREG_Human2.10014383
43CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02944147
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99788432
45GABP_19822575_ChIP-Seq_HepG2_Human1.96870077
46TAF15_26573619_Chip-Seq_HEK293_Human1.96719265
47TTF2_22483619_ChIP-Seq_HELA_Human1.96038283
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93564359
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91087494
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.91083321
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90255983
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.88920275
53ER_23166858_ChIP-Seq_MCF-7_Human1.83828192
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.82580603
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80357703
56* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.78917850
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76921456
58EWS_26573619_Chip-Seq_HEK293_Human1.74169267
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.73138801
60* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71924113
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71821241
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68390920
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64942740
64TP53_22573176_ChIP-Seq_HFKS_Human1.61411860
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60978203
66FUS_26573619_Chip-Seq_HEK293_Human1.59943351
67AR_21909140_ChIP-Seq_LNCAP_Human1.59319728
68IRF1_19129219_ChIP-ChIP_H3396_Human1.58925728
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.58661526
70CIITA_25753668_ChIP-Seq_RAJI_Human1.58595510
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55491729
72TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53389937
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.52960326
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52690340
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52646774
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51963143
77P300_19829295_ChIP-Seq_ESCs_Human1.49273298
78ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.49239944
79* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48768693
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.47996973
81FOXA1_27270436_Chip-Seq_PROSTATE_Human1.46251824
82FOXA1_25329375_ChIP-Seq_VCAP_Human1.46251824
83* GATA3_21878914_ChIP-Seq_MCF-7_Human1.46026529
84BCAT_22108803_ChIP-Seq_LS180_Human1.45325731
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44522395
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44149600
87PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39508949
88BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39449324
89ELK1_19687146_ChIP-ChIP_HELA_Human1.38008594
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.37798198
91AR_20517297_ChIP-Seq_VCAP_Human1.37445005
92CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34728052
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34267057
94STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33418797
95E2F1_21310950_ChIP-Seq_MCF-7_Human1.32210133
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32080451
97AR_25329375_ChIP-Seq_VCAP_Human1.30029343
98REST_21632747_ChIP-Seq_MESCs_Mouse1.29028963
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28864358
100CBP_20019798_ChIP-Seq_JUKART_Human1.28364816
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28364816
102ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28041489
103STAT3_23295773_ChIP-Seq_U87_Human1.27381220
104HOXB7_26014856_ChIP-Seq_BT474_Human1.26472935
105EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25983371
106FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24412200
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24161524
108SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23675275
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23651472
110ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23400995
111TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21341372
112ERA_21632823_ChIP-Seq_H3396_Human1.20428162
113* NANOG_19829295_ChIP-Seq_ESCs_Human1.20307150
114* SOX2_19829295_ChIP-Seq_ESCs_Human1.20307150
115NCOR_22424771_ChIP-Seq_293T_Human1.19815324
116TCF4_23295773_ChIP-Seq_U87_Human1.19628040
117KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18835327
118KDM5A_27292631_Chip-Seq_BREAST_Human1.17947441
119PIAS1_25552417_ChIP-Seq_VCAP_Human1.16951596
120* SMAD4_21799915_ChIP-Seq_A2780_Human1.16443570
121ZNF263_19887448_ChIP-Seq_K562_Human1.16052055
122FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15177776
123RNF2_27304074_Chip-Seq_NSC_Mouse1.15136212
124PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13731895
125NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11187952
126KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09379362
127GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09086800
128TCF4_22108803_ChIP-Seq_LS180_Human1.08902400
129* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08395210
130SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07166635
131KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06915749
132CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06719417
133ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06486775
134CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06346153
135CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05671953
136* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05599333
137* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05278649
138POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04450595
139TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04450595
140FLI1_21867929_ChIP-Seq_TH2_Mouse1.04137142
141MYC_18940864_ChIP-ChIP_HL60_Human1.03965800
142SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03906744
143MYC_19829295_ChIP-Seq_ESCs_Human1.03827158
144* RUNX2_22187159_ChIP-Seq_PCA_Human1.03766667
145NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03461251
146SMAD4_21741376_ChIP-Seq_EPCs_Human1.03233276
147REST_18959480_ChIP-ChIP_MESCs_Mouse1.03110559
148SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.01869888
149SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01864838
150MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00484067
151TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99829051
152HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99242696
153* OCT4_20526341_ChIP-Seq_ESCs_Human0.99136263
154TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99118006
155PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98383235
156P53_21459846_ChIP-Seq_SAOS-2_Human0.97585505
157* NANOG_20526341_ChIP-Seq_ESCs_Human0.95650837
158* TAF2_19829295_ChIP-Seq_ESCs_Human0.95444398
159POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95087897
160* YY1_22570637_ChIP-Seq_MALME-3M_Human0.95054565
161DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94769088
162* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94079585
163ELK1_22589737_ChIP-Seq_MCF10A_Human0.94010128
164FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93498301
165EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92532979
166CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92371866
167DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91027579
168OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90502365
169AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89932537
170PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.89269908
171FOXH1_21741376_ChIP-Seq_EPCs_Human0.88278773
172CTCF_18555785_ChIP-Seq_MESCs_Mouse0.87255970
173KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87159636
174SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86517121
175PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86086426
176TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83726819
177ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.81771585
178NOTCH1_21737748_ChIP-Seq_TLL_Human0.80787792
179FOXP1_21924763_ChIP-Seq_HESCs_Human0.80641138
180GATA4_21415370_ChIP-Seq_HL-1_Mouse0.80269489
181TFEB_21752829_ChIP-Seq_HELA_Human0.77357731

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle3.99514952
2MP0002837_dystrophic_cardiac_calcinosis3.65900233
3MP0003693_abnormal_embryo_hatching3.54364099
4MP0003646_muscle_fatigue3.52088008
5MP0003806_abnormal_nucleotide_metabolis3.41716425
6MP0006036_abnormal_mitochondrial_physio3.06531654
7MP0010094_abnormal_chromosome_stability2.95979185
8MP0004957_abnormal_blastocyst_morpholog2.92681562
9MP0005330_cardiomyopathy2.89212207
10MP0000749_muscle_degeneration2.80174592
11MP0004215_abnormal_myocardial_fiber2.75782804
12MP0003111_abnormal_nucleus_morphology2.74810745
13MP0003195_calcinosis2.70757334
14MP0003077_abnormal_cell_cycle2.70427864
15MP0004036_abnormal_muscle_relaxation2.66453270
16MP0001529_abnormal_vocalization2.57725727
17MP0009046_muscle_twitch2.56509062
18MP0000751_myopathy2.52774203
19MP0002653_abnormal_ependyma_morphology2.47553011
20MP0001968_abnormal_touch/_nociception2.38393866
21MP0002876_abnormal_thyroid_physiology2.36453899
22MP0008058_abnormal_DNA_repair2.22815081
23MP0006035_abnormal_mitochondrial_morpho2.22706435
24MP0008057_abnormal_DNA_replication2.22402104
25MP0003221_abnormal_cardiomyocyte_apopto2.21775633
26MP0008875_abnormal_xenobiotic_pharmacok2.18105415
27MP0003137_abnormal_impulse_conducting2.10263403
28MP0005551_abnormal_eye_electrophysiolog2.07667727
29MP0005670_abnormal_white_adipose2.01695593
30MP0000750_abnormal_muscle_regeneration1.98289875
31MP0002396_abnormal_hematopoietic_system1.94757506
32MP0002269_muscular_atrophy1.94436950
33MP0009745_abnormal_behavioral_response1.94209173
34MP0003567_abnormal_fetal_cardiomyocyte1.92670689
35MP0006138_congestive_heart_failure1.90829206
36MP0003123_paternal_imprinting1.88345713
37MP0004142_abnormal_muscle_tone1.88218451
38MP0002736_abnormal_nociception_after1.84643736
39MP0002972_abnormal_cardiac_muscle1.81144602
40MP0008007_abnormal_cellular_replicative1.81100456
41MP0008775_abnormal_heart_ventricle1.80992370
42MP0000427_abnormal_hair_cycle1.80934658
43MP0005385_cardiovascular_system_phenoty1.75834767
44MP0001544_abnormal_cardiovascular_syste1.75834767
45MP0003186_abnormal_redox_activity1.73040030
46MP0003136_yellow_coat_color1.72785443
47MP0006276_abnormal_autonomic_nervous1.71029577
48MP0005646_abnormal_pituitary_gland1.68868441
49MP0004087_abnormal_muscle_fiber1.66520490
50MP0008932_abnormal_embryonic_tissue1.66313875
51MP0008872_abnormal_physiological_respon1.64993734
52MP0004147_increased_porphyrin_level1.63559096
53MP0002272_abnormal_nervous_system1.61350785
54MP0010630_abnormal_cardiac_muscle1.58908007
55MP0001730_embryonic_growth_arrest1.57371363
56MP0005620_abnormal_muscle_contractility1.57184109
57MP0005253_abnormal_eye_physiology1.56031881
58MP0002735_abnormal_chemical_nociception1.54708550
59MP0001501_abnormal_sleep_pattern1.50624218
60MP0000747_muscle_weakness1.48688083
61MP0003786_premature_aging1.46866797
62MP0002106_abnormal_muscle_physiology1.45401457
63MP0000372_irregular_coat_pigmentation1.43566096
64MP0002138_abnormal_hepatobiliary_system1.42485482
65MP0002127_abnormal_cardiovascular_syste1.40389464
66MP0004043_abnormal_pH_regulation1.39828349
67MP0002572_abnormal_emotion/affect_behav1.36958491
68MP0005266_abnormal_metabolism1.35980406
69MP0003011_delayed_dark_adaptation1.34758655
70MP0006072_abnormal_retinal_apoptosis1.29869582
71MP0002733_abnormal_thermal_nociception1.28847892
72MP0003880_abnormal_central_pattern1.27354934
73MP0001485_abnormal_pinna_reflex1.26535232
74MP0004924_abnormal_behavior1.25589578
75MP0005386_behavior/neurological_phenoty1.25589578
76MP0001502_abnormal_circadian_rhythm1.24361802
77MP0002064_seizures1.23414482
78MP0005379_endocrine/exocrine_gland_phen1.22689045
79MP0006292_abnormal_olfactory_placode1.20826547
80MP0002557_abnormal_social/conspecific_i1.20299689
81MP0005380_embryogenesis_phenotype1.20159139
82MP0001672_abnormal_embryogenesis/_devel1.20159139
83MP0005666_abnormal_adipose_tissue1.19835964
84MP0005360_urolithiasis1.19557769
85MP0005645_abnormal_hypothalamus_physiol1.18254857
86MP0002909_abnormal_adrenal_gland1.18166323
87MP0001970_abnormal_pain_threshold1.18163995
88MP0004085_abnormal_heartbeat1.16907698
89MP0000358_abnormal_cell_content/1.16826557
90MP0002067_abnormal_sensory_capabilities1.16824350
91MP0005369_muscle_phenotype1.16151991
92MP0002088_abnormal_embryonic_growth/wei1.15313336
93MP0002160_abnormal_reproductive_system1.14847349
94MP0003984_embryonic_growth_retardation1.14733057
95MP0000631_abnormal_neuroendocrine_gland1.14544907
96MP0004145_abnormal_muscle_electrophysio1.14540532
97MP0000759_abnormal_skeletal_muscle1.14529144
98MP0003718_maternal_effect1.14364875
99MP0002163_abnormal_gland_morphology1.13936697
100MP0005389_reproductive_system_phenotype1.13466373
101MP0001486_abnormal_startle_reflex1.13415667
102MP0001697_abnormal_embryo_size1.12221232
103MP0004885_abnormal_endolymph1.10285243
104MP0001984_abnormal_olfaction1.09666979
105MP0005410_abnormal_fertilization1.09427106
106MP0009780_abnormal_chondrocyte_physiolo1.09084628
107MP0000569_abnormal_digit_pigmentation1.05635044
108MP0003828_pulmonary_edema1.05273681
109MP0003950_abnormal_plasma_membrane1.04971507
110MP0002080_prenatal_lethality1.03534834
111MP0010386_abnormal_urinary_bladder1.03354714
112MP0010329_abnormal_lipoprotein_level1.03190216
113MP0001986_abnormal_taste_sensitivity1.01950123
114MP0009379_abnormal_foot_pigmentation1.00694869
115MP0003787_abnormal_imprinting1.00210058
116MP0008789_abnormal_olfactory_epithelium1.00180707
117MP0003698_abnormal_male_reproductive1.00062883
118MP0002332_abnormal_exercise_endurance0.99610710
119MP0009697_abnormal_copulation0.99535964
120MP0003283_abnormal_digestive_organ0.99402445
121MP0003656_abnormal_erythrocyte_physiolo0.98321211
122MP0002938_white_spotting0.97919041
123MP0000350_abnormal_cell_proliferation0.97826313
124MP0001929_abnormal_gametogenesis0.96575517
125MP0001727_abnormal_embryo_implantation0.95263460
126MP0001919_abnormal_reproductive_system0.94922808
127MP0004130_abnormal_muscle_cell0.94699021
128MP0008995_early_reproductive_senescence0.94028506
129MP0004742_abnormal_vestibular_system0.93985231
130MP0000313_abnormal_cell_death0.93379339
131MP0001905_abnormal_dopamine_level0.93176475
132MP0002063_abnormal_learning/memory/cond0.91906227
133MP0002734_abnormal_mechanical_nocicepti0.90793717
134MP0000383_abnormal_hair_follicle0.90486597
135MP0003635_abnormal_synaptic_transmissio0.90135638
136MP0000230_abnormal_systemic_arterial0.89517340
137MP0001764_abnormal_homeostasis0.88683488
138MP0002229_neurodegeneration0.88157163
139MP0005195_abnormal_posterior_eye0.86658055
140MP0005332_abnormal_amino_acid0.85047620
141MP0002277_abnormal_respiratory_mucosa0.84936426
142MP0000049_abnormal_middle_ear0.84614986
143MP0005319_abnormal_enzyme/_coenzyme0.83902008
144MP0000026_abnormal_inner_ear0.82331339
145MP0005075_abnormal_melanosome_morpholog0.82282802
146MP0008877_abnormal_DNA_methylation0.80531879
147MP0002102_abnormal_ear_morphology0.79881466
148MP0004484_altered_response_of0.79185807
149MP0000538_abnormal_urinary_bladder0.77984003
150MP0005535_abnormal_body_temperature0.77439192
151MP0010030_abnormal_orbit_morphology0.77086123
152MP0002085_abnormal_embryonic_tissue0.76973711
153MP0004133_heterotaxia0.75672264
154MP0009672_abnormal_birth_weight0.74515943
155MP0002019_abnormal_tumor_incidence0.72769483
156MP0005084_abnormal_gallbladder_morpholo0.70364514
157MP0000537_abnormal_urethra_morphology0.69076783
158MP0005376_homeostasis/metabolism_phenot0.68269727
159MP0000266_abnormal_heart_morphology0.67960996
160MP0000343_altered_response_to0.67583489
161MP0005085_abnormal_gallbladder_physiolo0.67129281
162MP0002132_abnormal_respiratory_system0.64882888
163MP0002638_abnormal_pupillary_reflex0.64011922
164MP0002210_abnormal_sex_determination0.63139302
165MP0005451_abnormal_body_composition0.62206711
166MP0002234_abnormal_pharynx_morphology0.59728317
167MP0005365_abnormal_bile_salt0.59636068
168MP0004233_abnormal_muscle_weight0.58353293
169MP0001145_abnormal_male_reproductive0.56790139
170MP0003878_abnormal_ear_physiology0.56572992
171MP0005377_hearing/vestibular/ear_phenot0.56572992
172MP0002086_abnormal_extraembryonic_tissu0.56438322

Predicted human phenotypes

RankGene SetZ-score
1Hepatic necrosis (HP:0002605)4.90654456
2Acute necrotizing encephalopathy (HP:0006965)4.76485945
3Hepatocellular necrosis (HP:0001404)4.68756269
4Abnormal mitochondria in muscle tissue (HP:0008316)4.64262999
5Abnormality of glycolysis (HP:0004366)4.41938979
6Increased serum pyruvate (HP:0003542)4.41938979
7Mitochondrial inheritance (HP:0001427)4.21588924
8Abnormality of midbrain morphology (HP:0002418)4.20549234
9Molar tooth sign on MRI (HP:0002419)4.20549234
10Acute encephalopathy (HP:0006846)4.20339199
11Increased CSF lactate (HP:0002490)4.16197501
12Pancreatic cysts (HP:0001737)4.09359419
13Pancreatic fibrosis (HP:0100732)3.96128081
14Abnormality of cells of the erythroid lineage (HP:0012130)3.90040436
15Hyperventilation (HP:0002883)3.87557080
16Progressive macrocephaly (HP:0004481)3.83631921
17Type II lissencephaly (HP:0007260)3.80422787
18Rhabdomyolysis (HP:0003201)3.73522347
19Nephronophthisis (HP:0000090)3.69185117
20Abnormal number of erythroid precursors (HP:0012131)3.66874652
21Increased muscle lipid content (HP:0009058)3.61088642
22True hermaphroditism (HP:0010459)3.59730396
23Abnormality of the renal cortex (HP:0011035)3.49460615
24Cerebral edema (HP:0002181)3.46369401
25Myoglobinuria (HP:0002913)3.45511683
26Increased serum lactate (HP:0002151)3.45496935
27Lactic acidosis (HP:0003128)3.44817814
28Exercise intolerance (HP:0003546)3.40315465
29Lipid accumulation in hepatocytes (HP:0006561)3.35898216
30Ventricular tachycardia (HP:0004756)3.35284981
31Dicarboxylic aciduria (HP:0003215)3.27447559
32Abnormality of dicarboxylic acid metabolism (HP:0010995)3.27447559
33Decreased activity of mitochondrial respiratory chain (HP:0008972)3.27177976
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.27177976
35Medial flaring of the eyebrow (HP:0010747)3.22950786
36Increased intramyocellular lipid droplets (HP:0012240)3.21976680
37Sudden death (HP:0001699)3.20261238
38Abnormality of the renal medulla (HP:0100957)3.14772338
39Abnormality of fatty-acid metabolism (HP:0004359)3.12990673
40Renal cortical cysts (HP:0000803)3.09174703
41Palpitations (HP:0001962)3.05240279
42Respiratory failure (HP:0002878)3.04343445
43Congenital stationary night blindness (HP:0007642)3.02231578
44Abnormality of alanine metabolism (HP:0010916)3.00621284
45Hyperalaninemia (HP:0003348)3.00621284
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.00621284
47Large for gestational age (HP:0001520)2.98000573
48Reticulocytopenia (HP:0001896)2.93890842
49Attenuation of retinal blood vessels (HP:0007843)2.89510091
50Birth length less than 3rd percentile (HP:0003561)2.88588856
51Increased hepatocellular lipid droplets (HP:0006565)2.86147966
52Lipoatrophy (HP:0100578)2.84855455
53Nausea (HP:0002018)2.82326504
54Congenital, generalized hypertrichosis (HP:0004540)2.79603267
55Inability to walk (HP:0002540)2.76838712
56Gait imbalance (HP:0002141)2.73765287
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.70449971
58Congenital primary aphakia (HP:0007707)2.65480104
593-Methylglutaconic aciduria (HP:0003535)2.63026443
60Progressive external ophthalmoplegia (HP:0000590)2.61761867
61Oral leukoplakia (HP:0002745)2.61706757
62Multiple enchondromatosis (HP:0005701)2.59359102
63Cystic liver disease (HP:0006706)2.59032280
64Ragged-red muscle fibers (HP:0003200)2.58865545
65Severe muscular hypotonia (HP:0006829)2.57303635
66Nephrogenic diabetes insipidus (HP:0009806)2.56921166
67Exercise-induced myalgia (HP:0003738)2.55115198
68Hyperglycinuria (HP:0003108)2.54987814
69Exercise-induced muscle cramps (HP:0003710)2.53999294
70CNS demyelination (HP:0007305)2.53575923
71Dilated cardiomyopathy (HP:0001644)2.45870527
72Progressive inability to walk (HP:0002505)2.45764419
73Cerebral hypomyelination (HP:0006808)2.44177652
74Macrocytic anemia (HP:0001972)2.43055852
75Atrial fibrillation (HP:0005110)2.42967018
76Rough bone trabeculation (HP:0100670)2.42396936
77Lethargy (HP:0001254)2.41798506
78Microretrognathia (HP:0000308)2.41025287
79Hypoplasia of the capital femoral epiphysis (HP:0003090)2.40980191
80Tubular atrophy (HP:0000092)2.38308048
81Generalized aminoaciduria (HP:0002909)2.37313754
82Calf muscle hypertrophy (HP:0008981)2.37093217
83Emotional lability (HP:0000712)2.36347684
84Supraventricular tachycardia (HP:0004755)2.36339301
85Sclerocornea (HP:0000647)2.35677602
86Concave nail (HP:0001598)2.35277669
87Hypoglycemic coma (HP:0001325)2.35205836
88Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.34154732
89Muscle fiber splitting (HP:0003555)2.33885136
90Chronic hepatic failure (HP:0100626)2.33009009
91Cerebellar dysplasia (HP:0007033)2.32981484
92Lissencephaly (HP:0001339)2.31111291
93Abnormal rod and cone electroretinograms (HP:0008323)2.30872556
94Muscle stiffness (HP:0003552)2.28804327
95Supraventricular arrhythmia (HP:0005115)2.27626901
96Primary atrial arrhythmia (HP:0001692)2.25504289
97Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.25241621
98Abolished electroretinogram (ERG) (HP:0000550)2.23589091
99Furrowed tongue (HP:0000221)2.22760028
100Limb dystonia (HP:0002451)2.22723957
101Polydipsia (HP:0001959)2.21405181
102Abnormal drinking behavior (HP:0030082)2.21405181
103Absent/shortened dynein arms (HP:0200106)2.19925340
104Dynein arm defect of respiratory motile cilia (HP:0012255)2.19925340
105Congenital hepatic fibrosis (HP:0002612)2.19223474
106Ureteral duplication (HP:0000073)2.19171520
107Decreased central vision (HP:0007663)2.18433838
108Respiratory difficulties (HP:0002880)2.18214775
109Aplasia/Hypoplasia of the tongue (HP:0010295)2.17939160
110Colon cancer (HP:0003003)2.17886900
111Areflexia of lower limbs (HP:0002522)2.17172433
112Neoplasm of the adrenal gland (HP:0100631)2.17022283
113Abnormality of glycine metabolism (HP:0010895)2.16919566
114Abnormality of serine family amino acid metabolism (HP:0010894)2.16919566
115Ketosis (HP:0001946)2.16740284
116Leukodystrophy (HP:0002415)2.16320823
117Breast hypoplasia (HP:0003187)2.15655757
118Muscle hypertrophy of the lower extremities (HP:0008968)2.13783009
119Broad-based gait (HP:0002136)2.13613169
120Hyperammonemia (HP:0001987)2.13532763
121Retinal dysplasia (HP:0007973)2.13303058
122Abnormality of the left ventricular outflow tract (HP:0011103)2.13098433
123Subaortic stenosis (HP:0001682)2.13098433
124Pendular nystagmus (HP:0012043)2.10239099
125Bile duct proliferation (HP:0001408)2.07546688
126Abnormal biliary tract physiology (HP:0012439)2.07546688
127Aplasia/Hypoplasia of the tibia (HP:0005772)2.04878092
128Pachygyria (HP:0001302)2.04401924
129Bony spicule pigmentary retinopathy (HP:0007737)2.04274033
130Anencephaly (HP:0002323)2.03735881
131Fair hair (HP:0002286)2.03446494
132Aplastic anemia (HP:0001915)2.02994254
133Left ventricular hypertrophy (HP:0001712)2.01865343
134Optic disc pallor (HP:0000543)2.00612796
135Fibular aplasia (HP:0002990)2.00217923
136Brushfield spots (HP:0001088)1.96235952
137Decreased circulating renin level (HP:0003351)1.95430733
138Tachypnea (HP:0002789)1.95045575
139Gaze-evoked nystagmus (HP:0000640)1.93149330
140Abnormality of the preputium (HP:0100587)1.93021452
141Methylmalonic acidemia (HP:0002912)1.92898240
142Conjunctival hamartoma (HP:0100780)1.92399856
143Carpal bone hypoplasia (HP:0001498)1.91639835
144Male pseudohermaphroditism (HP:0000037)1.91351615
145Renal Fanconi syndrome (HP:0001994)1.91235424
146Progressive microcephaly (HP:0000253)1.91010358
147Polyuria (HP:0000103)1.89601401
148Pallor (HP:0000980)1.89469750
149Angiofibromas (HP:0010615)1.87126561
150Adenoma sebaceum (HP:0009720)1.87126561
151Hyperglycinemia (HP:0002154)1.87003390
152Exertional dyspnea (HP:0002875)1.86683712
153Postaxial foot polydactyly (HP:0001830)1.86230711
154Genital tract atresia (HP:0001827)1.85080627
155Unsteady gait (HP:0002317)1.84420303
156Increased corneal curvature (HP:0100692)1.83259682
157Keratoconus (HP:0000563)1.83259682
158Abnormal respiratory epithelium morphology (HP:0012253)1.83175025
159Abnormal respiratory motile cilium morphology (HP:0005938)1.83175025
160Delayed CNS myelination (HP:0002188)1.82082153
161Hypothermia (HP:0002045)1.82063283
162Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.80816620
163Aplasia/hypoplasia of the uterus (HP:0008684)1.78780650
164External ophthalmoplegia (HP:0000544)1.78769093
165Ketoacidosis (HP:0001993)1.78581593
166Hypoplastic ischia (HP:0003175)1.78324101
167Methylmalonic aciduria (HP:0012120)1.78020012
168Hyporeflexia of lower limbs (HP:0002600)1.77923789
169Patellar aplasia (HP:0006443)1.77865210
170Chromosomal breakage induced by crosslinking agents (HP:0003221)1.77622243
171Vaginal atresia (HP:0000148)1.77098147

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.87603748
2BMPR1B4.33425832
3FRK4.15371983
4MAP4K23.65755016
5BCKDK3.59283890
6TIE13.52376760
7STK163.45093321
8WEE13.44596555
9NME22.70832848
10TSSK62.60925447
11NEK12.55941038
12CDC72.41761026
13WNK42.35399601
14EIF2AK12.31962903
15PDK32.31698452
16PDK42.31698452
17TLK12.31195065
18BRSK22.30316496
19VRK12.17793937
20CCNB12.15870740
21MAP3K42.01006992
22OBSCN2.00890313
23MYLK1.96408431
24WNK31.95340735
25SRPK11.89400655
26NUAK11.80571602
27MAPK131.80450896
28INSRR1.76363869
29NME11.72233250
30PLK41.67860474
31TTK1.63454698
32MAP2K71.62124945
33CSNK1G31.56704851
34TAOK31.56268382
35CASK1.55800900
36ZAK1.49884380
37CSNK1G21.47123292
38PLK11.40576445
39NEK21.36767247
40CSNK1G11.35144752
41TTN1.33967389
42DYRK31.32133641
43PLK31.31030340
44RPS6KB21.28819309
45AURKB1.26008313
46FLT31.24980714
47BRSK11.24570777
48CAMKK21.23474891
49PINK11.21618144
50OXSR11.20887718
51ERN11.20707693
52PDK21.20256867
53STK241.16677485
54PAK31.13513920
55ILK1.13105174
56TGFBR11.10129237
57PASK1.07414952
58STK391.06035717
59EIF2AK31.04784797
60MUSK1.04616948
61LIMK11.04573504
62MAP2K61.02840617
63PHKG11.02572481
64PHKG21.02572481
65ARAF1.01764163
66MAPK150.99746346
67NTRK30.97633367
68PIK3CA0.95408059
69CDK190.94846891
70DAPK20.94617178
71ADRBK10.93555017
72PRKCG0.92097154
73MARK10.91373894
74KDR0.90766263
75ATR0.89745235
76PKN20.89003992
77MKNK10.88307498
78CDK70.87623681
79AURKA0.86526071
80PRKCE0.85730599
81PNCK0.81109556
82PIM20.80481422
83AKT20.80360096
84MAPKAPK50.78566274
85CSNK1A1L0.78139879
86ACVR1B0.77987589
87MAP2K30.77846127
88DYRK20.75080530
89PIK3CG0.73051325
90STK40.71567658
91TRIM280.71562593
92BRAF0.71223597
93EIF2AK20.68828242
94BCR0.66447406
95LMTK20.65772438
96CSNK2A10.64958381
97EPHA40.64792461
98PTK2B0.62878608
99MAPKAPK30.62477581
100STK38L0.61829728
101TAOK20.59288477
102MAP2K40.59040283
103TXK0.58206005
104CSNK2A20.57133399
105MAP2K10.55369941
106PAK40.55316594
107PRKCQ0.53597895
108CHEK10.51767066
109CHEK20.50644578
110ERBB30.49876292
111PLK20.49651054
112DYRK1B0.47883412
113PAK10.47159718
114PRKAA20.46620834
115CAMK2A0.46213402
116DAPK30.46054111
117PRKACA0.44931716
118GRK70.44779382
119MET0.44608344
120ABL20.44491563
121CSNK1A10.44252223
122IKBKB0.43783451
123MAP3K80.43516682
124PRKAA10.43468426
125TEC0.43270723
126TNIK0.41745377
127NTRK20.41384303
128MST40.40756025
129CDK40.39794598
130PKN10.39543076
131MKNK20.38710769
132ADRBK20.38071245
133PRKCI0.37841790
134TESK20.37600475
135PRKCZ0.37398477
136MAP3K120.36983883
137GRK10.36043711
138TNK20.35590875
139MAP3K70.35557238
140CAMK40.34903299
141CSNK1D0.34620382
142CDK20.34278098
143MAP2K20.33821951
144PRKCA0.33034574
145IRAK10.32769814
146MAPK120.32710399
147RPS6KC10.31654677
148RPS6KL10.31654677
149RPS6KA50.31218066
150CHUK0.30359349
151CDK10.30078360
152CDK80.30058668
153MAPK40.29950024
154ATM0.29493681
155EPHA30.28521909
156LRRK20.28346559
157RPS6KA60.27723182
158CAMK10.27380827
159CAMK2D0.26694092
160PRKG10.26682350
161PRKACB0.26632866
162UHMK10.25902302
163BTK0.24608547
164KIT0.23693985

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.97469383
2Ribosome_Homo sapiens_hsa030103.62556283
3DNA replication_Homo sapiens_hsa030303.39539654
4Proteasome_Homo sapiens_hsa030503.35775348
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.06321205
6Parkinsons disease_Homo sapiens_hsa050122.95607549
7Oxidative phosphorylation_Homo sapiens_hsa001902.95393047
8Mismatch repair_Homo sapiens_hsa034302.83979069
9RNA polymerase_Homo sapiens_hsa030202.67600644
10Nitrogen metabolism_Homo sapiens_hsa009102.46695743
11Propanoate metabolism_Homo sapiens_hsa006402.39883820
12Base excision repair_Homo sapiens_hsa034102.27328862
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.25638575
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.24267369
15Spliceosome_Homo sapiens_hsa030402.22697336
16Huntingtons disease_Homo sapiens_hsa050162.21435183
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.17631336
18Pyrimidine metabolism_Homo sapiens_hsa002402.08772467
19Carbon metabolism_Homo sapiens_hsa012002.07131762
20Homologous recombination_Homo sapiens_hsa034401.99145825
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.99039950
22Phototransduction_Homo sapiens_hsa047441.91858760
23RNA transport_Homo sapiens_hsa030131.89550926
24Alzheimers disease_Homo sapiens_hsa050101.84979681
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.77938147
26Cardiac muscle contraction_Homo sapiens_hsa042601.77044560
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.76403851
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.74440343
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.72755617
30Fatty acid degradation_Homo sapiens_hsa000711.72540646
31Pyruvate metabolism_Homo sapiens_hsa006201.70484617
32Nucleotide excision repair_Homo sapiens_hsa034201.66185446
33Nicotine addiction_Homo sapiens_hsa050331.60435813
34Biosynthesis of amino acids_Homo sapiens_hsa012301.59093662
35One carbon pool by folate_Homo sapiens_hsa006701.58568657
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.58316065
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55581403
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.49948013
39Fatty acid elongation_Homo sapiens_hsa000621.43477037
40Vitamin B6 metabolism_Homo sapiens_hsa007501.40126298
41Fatty acid metabolism_Homo sapiens_hsa012121.39657940
42Caffeine metabolism_Homo sapiens_hsa002321.38470112
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.38166511
44Fanconi anemia pathway_Homo sapiens_hsa034601.35670205
45Purine metabolism_Homo sapiens_hsa002301.30500445
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.29603335
47Cell cycle_Homo sapiens_hsa041101.28420447
48Sulfur metabolism_Homo sapiens_hsa009201.25361640
49Circadian rhythm_Homo sapiens_hsa047101.25291163
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.24997892
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.24467272
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23859012
53Folate biosynthesis_Homo sapiens_hsa007901.21534095
54RNA degradation_Homo sapiens_hsa030181.18046484
55ABC transporters_Homo sapiens_hsa020101.17720319
56Ether lipid metabolism_Homo sapiens_hsa005651.15888159
57Pentose phosphate pathway_Homo sapiens_hsa000301.12288546
58* Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11583178
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10876412
60Non-homologous end-joining_Homo sapiens_hsa034501.01125192
61Peroxisome_Homo sapiens_hsa041460.97568099
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95206182
63Butanoate metabolism_Homo sapiens_hsa006500.94821815
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93715024
65Retinol metabolism_Homo sapiens_hsa008300.92650693
66Taste transduction_Homo sapiens_hsa047420.91383304
67Basal transcription factors_Homo sapiens_hsa030220.90422017
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.89331906
69Glutathione metabolism_Homo sapiens_hsa004800.88548408
70Steroid biosynthesis_Homo sapiens_hsa001000.87794310
71Fructose and mannose metabolism_Homo sapiens_hsa000510.87402422
72Protein export_Homo sapiens_hsa030600.85395507
73Sulfur relay system_Homo sapiens_hsa041220.84299886
74beta-Alanine metabolism_Homo sapiens_hsa004100.82284871
75* Metabolic pathways_Homo sapiens_hsa011000.80082246
76Insulin secretion_Homo sapiens_hsa049110.79296479
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.79102635
78Ovarian steroidogenesis_Homo sapiens_hsa049130.79086903
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78799764
80Collecting duct acid secretion_Homo sapiens_hsa049660.77781615
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77210790
82Morphine addiction_Homo sapiens_hsa050320.75633913
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73241864
84Galactose metabolism_Homo sapiens_hsa000520.72549866
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69489385
86PPAR signaling pathway_Homo sapiens_hsa033200.69243391
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.66854153
88Cocaine addiction_Homo sapiens_hsa050300.66796114
89Serotonergic synapse_Homo sapiens_hsa047260.66548882
90Olfactory transduction_Homo sapiens_hsa047400.66431973
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65621755
92Arginine and proline metabolism_Homo sapiens_hsa003300.65406459
93mRNA surveillance pathway_Homo sapiens_hsa030150.65158563
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63325327
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63147345
96GABAergic synapse_Homo sapiens_hsa047270.62284502
97Phenylalanine metabolism_Homo sapiens_hsa003600.54729599
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53577482
99Tryptophan metabolism_Homo sapiens_hsa003800.52979000
100Amphetamine addiction_Homo sapiens_hsa050310.52963712
101p53 signaling pathway_Homo sapiens_hsa041150.52164897
102Calcium signaling pathway_Homo sapiens_hsa040200.48892507
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47887949
104Mineral absorption_Homo sapiens_hsa049780.47769383
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47453297
106Glutamatergic synapse_Homo sapiens_hsa047240.47332090
107Circadian entrainment_Homo sapiens_hsa047130.47054604
108Selenocompound metabolism_Homo sapiens_hsa004500.46908411
109Epstein-Barr virus infection_Homo sapiens_hsa051690.46573051
110Tyrosine metabolism_Homo sapiens_hsa003500.45865172
111Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45627935
112Dopaminergic synapse_Homo sapiens_hsa047280.44728678
113Systemic lupus erythematosus_Homo sapiens_hsa053220.39595940
114Dilated cardiomyopathy_Homo sapiens_hsa054140.38494109
115Fat digestion and absorption_Homo sapiens_hsa049750.36191231
116Linoleic acid metabolism_Homo sapiens_hsa005910.36013745
117Arginine biosynthesis_Homo sapiens_hsa002200.35779684
118Salivary secretion_Homo sapiens_hsa049700.35621938
119Arachidonic acid metabolism_Homo sapiens_hsa005900.33134032
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30132400
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28569282
122Primary bile acid biosynthesis_Homo sapiens_hsa001200.28524449
123Oocyte meiosis_Homo sapiens_hsa041140.22887054
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22649622
125Starch and sucrose metabolism_Homo sapiens_hsa005000.22500986
126HIF-1 signaling pathway_Homo sapiens_hsa040660.21941723
127Regulation of autophagy_Homo sapiens_hsa041400.20702505
128Glucagon signaling pathway_Homo sapiens_hsa049220.12122935
129Chemical carcinogenesis_Homo sapiens_hsa052040.11816386
130Glycerolipid metabolism_Homo sapiens_hsa005610.10880047
131Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.10719181
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.10217506
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.10187138
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.07214109
135Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.07023050
136Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.01720056
137N-Glycan biosynthesis_Homo sapiens_hsa005100.01223135
138Herpes simplex infection_Homo sapiens_hsa051680.01129319
139Histidine metabolism_Homo sapiens_hsa003400.01024388
140Vitamin digestion and absorption_Homo sapiens_hsa049770.00352813

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