COQ7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development and longer life span. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.32841572
2ATP synthesis coupled proton transport (GO:0015986)7.77827654
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.77827654
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.36421302
5* respiratory electron transport chain (GO:0022904)6.67344386
6* electron transport chain (GO:0022900)6.49508209
7mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.07985810
8mitochondrial respiratory chain complex I assembly (GO:0032981)5.07985810
9NADH dehydrogenase complex assembly (GO:0010257)5.07985810
10protein complex biogenesis (GO:0070271)4.96913373
11protein neddylation (GO:0045116)4.85304286
12oxidative phosphorylation (GO:0006119)4.78560740
13establishment of protein localization to mitochondrial membrane (GO:0090151)4.73519346
14mitochondrial respiratory chain complex assembly (GO:0033108)4.66012811
15chaperone-mediated protein transport (GO:0072321)4.64995346
16regulation of mitochondrial translation (GO:0070129)4.61288873
17proteasome assembly (GO:0043248)4.58977420
18piRNA metabolic process (GO:0034587)4.16108719
19cullin deneddylation (GO:0010388)4.14036012
20ATP biosynthetic process (GO:0006754)4.05588593
21termination of RNA polymerase III transcription (GO:0006386)4.00449636
22transcription elongation from RNA polymerase III promoter (GO:0006385)4.00449636
23cellular ketone body metabolic process (GO:0046950)3.99937713
24purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.96651531
25inner mitochondrial membrane organization (GO:0007007)3.92798966
26purine nucleoside triphosphate biosynthetic process (GO:0009145)3.91085956
27hydrogen ion transmembrane transport (GO:1902600)3.85592034
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.83027007
29regulation of cellular amino acid metabolic process (GO:0006521)3.79897460
30protein deneddylation (GO:0000338)3.73080862
31GTP biosynthetic process (GO:0006183)3.65371814
32protein targeting to mitochondrion (GO:0006626)3.60270504
33positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.58124303
34establishment of protein localization to mitochondrion (GO:0072655)3.56974211
35ketone body metabolic process (GO:1902224)3.55589073
36ribonucleoside triphosphate biosynthetic process (GO:0009201)3.48194921
37negative regulation of ligase activity (GO:0051352)3.48038998
38negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.48038998
39L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.47818680
40regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.43834444
41anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.40845038
42protein-cofactor linkage (GO:0018065)3.40119519
43aerobic respiration (GO:0009060)3.37705790
44proton transport (GO:0015992)3.36583700
45ribosomal small subunit biogenesis (GO:0042274)3.35869628
46positive regulation of mitochondrial fission (GO:0090141)3.35408916
47protein localization to mitochondrion (GO:0070585)3.32517752
48respiratory chain complex IV assembly (GO:0008535)3.31140042
49axonemal dynein complex assembly (GO:0070286)3.29845005
50hydrogen transport (GO:0006818)3.28581040
51DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.25260851
52pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.24614946
53tricarboxylic acid cycle (GO:0006099)3.24042442
54pseudouridine synthesis (GO:0001522)3.22699177
55male meiosis I (GO:0007141)3.21159984
567-methylguanosine mRNA capping (GO:0006370)3.20392077
57protein localization to cilium (GO:0061512)3.19923616
58establishment of integrated proviral latency (GO:0075713)3.19474170
59ribosomal large subunit biogenesis (GO:0042273)3.18188669
60intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.17838748
61signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.17838748
62guanosine-containing compound biosynthetic process (GO:1901070)3.17503449
63signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.17327154
64signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.17327154
65signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.17327154
66regulation of relaxation of muscle (GO:1901077)3.17316986
677-methylguanosine RNA capping (GO:0009452)3.16568191
68RNA capping (GO:0036260)3.16568191
69maturation of 5.8S rRNA (GO:0000460)3.14842333
70nucleoside triphosphate biosynthetic process (GO:0009142)3.13669298
71behavioral response to nicotine (GO:0035095)3.12424096
72regulation of glucokinase activity (GO:0033131)3.11405935
73regulation of hexokinase activity (GO:1903299)3.11405935
74UTP biosynthetic process (GO:0006228)3.11023400
75signal transduction involved in DNA integrity checkpoint (GO:0072401)3.09442554
76signal transduction involved in DNA damage checkpoint (GO:0072422)3.09442554
77signal transduction involved in cell cycle checkpoint (GO:0072395)3.08333540
78positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.07500639
79regulation of skeletal muscle contraction (GO:0014819)3.07341321
80DNA methylation involved in gamete generation (GO:0043046)3.05645608
81cilium or flagellum-dependent cell motility (GO:0001539)3.04690386
82translation (GO:0006412)3.04617513
83mitochondrial transport (GO:0006839)3.04606949
84branched-chain amino acid catabolic process (GO:0009083)3.04107707
85rRNA modification (GO:0000154)3.02732679
86inositol phosphate catabolic process (GO:0071545)3.00834292
87viral transcription (GO:0019083)3.00134465
88cytochrome complex assembly (GO:0017004)2.99431697
89spliceosomal snRNP assembly (GO:0000387)2.99231634
90intraciliary transport (GO:0042073)2.98957014
91positive regulation of ligase activity (GO:0051351)2.97303342
92muscle filament sliding (GO:0030049)2.97116904
93actin-myosin filament sliding (GO:0033275)2.97116904
94metallo-sulfur cluster assembly (GO:0031163)2.95779580
95iron-sulfur cluster assembly (GO:0016226)2.95779580
96regulation of cellular amine metabolic process (GO:0033238)2.95355032
97polyol catabolic process (GO:0046174)2.94631128
98axoneme assembly (GO:0035082)2.91495868
99DNA damage response, detection of DNA damage (GO:0042769)2.91461621
100* quinone biosynthetic process (GO:1901663)2.91318591
101* ubiquinone biosynthetic process (GO:0006744)2.91318591
102spliceosomal complex assembly (GO:0000245)2.91055552
103translational termination (GO:0006415)2.90946264
104antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.89800870
105cellular component biogenesis (GO:0044085)2.87580448
106phosphorylated carbohydrate dephosphorylation (GO:0046838)2.87082284
107inositol phosphate dephosphorylation (GO:0046855)2.87082284
108transcription from RNA polymerase I promoter (GO:0006360)2.86678149
109amino acid salvage (GO:0043102)2.84438646
110L-methionine salvage (GO:0071267)2.84438646
111L-methionine biosynthetic process (GO:0071265)2.84438646
112DNA double-strand break processing (GO:0000729)2.83139295
113cotranslational protein targeting to membrane (GO:0006613)2.80723066
114regulation of cellular respiration (GO:0043457)2.79729805
115maturation of SSU-rRNA (GO:0030490)2.79443697
116deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.78534873
117purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.78510661
118purine nucleoside monophosphate biosynthetic process (GO:0009127)2.78510661
119epithelial cilium movement (GO:0003351)2.78158142
120resolution of meiotic recombination intermediates (GO:0000712)2.77299252
121establishment of viral latency (GO:0019043)2.77188025
122peptidyl-histidine modification (GO:0018202)2.75528157
123SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.74031106
124protein targeting to ER (GO:0045047)2.71983750
125cilium movement (GO:0003341)2.68554548
126motile cilium assembly (GO:0044458)2.68262139
127* ubiquinone metabolic process (GO:0006743)2.68244403
128regulation of ubiquitin-protein transferase activity (GO:0051438)2.68225565
129cellular respiration (GO:0045333)2.68053591
130epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.67623979
131mannosylation (GO:0097502)2.65854875
132UTP metabolic process (GO:0046051)2.64719125
133aspartate family amino acid catabolic process (GO:0009068)2.63909378
134meiosis I (GO:0007127)2.63250369
135heart process (GO:0003015)2.63110038
136heart contraction (GO:0060047)2.63110038
137base-excision repair, AP site formation (GO:0006285)2.62914398
138somite development (GO:0061053)2.62429178
139preassembly of GPI anchor in ER membrane (GO:0016254)2.62425217
140protein localization to endoplasmic reticulum (GO:0070972)2.62388975
141protein polyglutamylation (GO:0018095)2.61818479
142transcription elongation from RNA polymerase I promoter (GO:0006362)2.61767759
143pyrimidine nucleotide catabolic process (GO:0006244)2.59581581
144platelet dense granule organization (GO:0060155)2.58042110
145regulation of cilium movement (GO:0003352)2.57547412
146negative regulation of cytosolic calcium ion concentration (GO:0051481)2.55864014
147cilium organization (GO:0044782)2.55167438
148replication fork processing (GO:0031297)2.50750677
149cilium assembly (GO:0042384)2.50161630
150pyrimidine nucleobase catabolic process (GO:0006208)2.48088494
151branched-chain amino acid metabolic process (GO:0009081)2.46984141
152male meiosis (GO:0007140)2.46491499
153kynurenine metabolic process (GO:0070189)2.40828734
154cornea development in camera-type eye (GO:0061303)2.40476813
155translesion synthesis (GO:0019985)2.40426994
156pyrimidine dimer repair (GO:0006290)2.38568450
157deoxyribose phosphate catabolic process (GO:0046386)2.36422777
158adenosine metabolic process (GO:0046085)2.36309347
159DNA integration (GO:0015074)2.35064783
160somatic diversification of immune receptors via somatic mutation (GO:0002566)2.34413822
161somatic hypermutation of immunoglobulin genes (GO:0016446)2.34413822
162establishment of mitochondrion localization (GO:0051654)2.33888462
163neuronal action potential propagation (GO:0019227)2.33524955
164nucleotide transmembrane transport (GO:1901679)2.33462332
165regulation of meiosis I (GO:0060631)2.33256873
166regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.33030881
167regulation of action potential (GO:0098900)2.33012485
168positive regulation of male gonad development (GO:2000020)2.32963526
169actin-mediated cell contraction (GO:0070252)2.32154354
170nonmotile primary cilium assembly (GO:0035058)2.31694629
171deoxyribonucleotide catabolic process (GO:0009264)2.31305809
172DNA deamination (GO:0045006)2.31247496
173tryptophan catabolic process (GO:0006569)2.30472140
174indole-containing compound catabolic process (GO:0042436)2.30472140
175indolalkylamine catabolic process (GO:0046218)2.30472140

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.15093033
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.80572621
3* EST1_17652178_ChIP-ChIP_JURKAT_Human3.75889111
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.74776062
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.71846173
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.70603518
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.39378708
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.34446811
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.29712508
10IGF1R_20145208_ChIP-Seq_DFB_Human3.20960174
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.19722932
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.19614095
13MYC_18555785_ChIP-Seq_MESCs_Mouse3.15549815
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.10493291
15* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.89779785
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.85696093
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.63375042
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.47204667
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.46527494
20* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.44080616
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.37748096
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36925626
23* SRF_21415370_ChIP-Seq_HL-1_Mouse2.35936298
24YY1_21170310_ChIP-Seq_MESCs_Mouse2.24350746
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.16505763
26MYC_19030024_ChIP-ChIP_MESCs_Mouse2.12545830
27RBPJ_22232070_ChIP-Seq_NCS_Mouse2.10228230
28* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.03317293
29DCP1A_22483619_ChIP-Seq_HELA_Human1.99564576
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98869588
31* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.92575167
32EZH2_22144423_ChIP-Seq_EOC_Human1.91936460
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87894291
34VDR_23849224_ChIP-Seq_CD4+_Human1.86558021
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.84472236
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.83165546
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74209527
38VDR_22108803_ChIP-Seq_LS180_Human1.70888297
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67941308
40FOXP3_21729870_ChIP-Seq_TREG_Human1.63478455
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.63318684
42TTF2_22483619_ChIP-Seq_HELA_Human1.62713023
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.58764154
44* XRN2_22483619_ChIP-Seq_HELA_Human1.58187926
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.57106564
46TP53_22573176_ChIP-Seq_HFKS_Human1.55350713
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54142245
48P300_19829295_ChIP-Seq_ESCs_Human1.53986248
49ELK1_19687146_ChIP-ChIP_HELA_Human1.53127098
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51255915
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49155906
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.46813489
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.44628348
54MYC_18940864_ChIP-ChIP_HL60_Human1.43812895
55IRF1_19129219_ChIP-ChIP_H3396_Human1.41294127
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38740654
57* GABP_19822575_ChIP-Seq_HepG2_Human1.38084067
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.35556832
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.32743362
60KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32439942
61AR_21572438_ChIP-Seq_LNCaP_Human1.28877465
62CBP_20019798_ChIP-Seq_JUKART_Human1.26714758
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26714758
64* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.24472879
65CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.23945770
66FUS_26573619_Chip-Seq_HEK293_Human1.22052079
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21302829
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18275655
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17776812
70CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17743433
71NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17049505
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17041292
73TAF15_26573619_Chip-Seq_HEK293_Human1.16861268
74SOX2_19829295_ChIP-Seq_ESCs_Human1.16382686
75NANOG_19829295_ChIP-Seq_ESCs_Human1.16382686
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15060167
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14006682
78E2F7_22180533_ChIP-Seq_HELA_Human1.13917110
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13627040
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13428271
81HOXB7_26014856_ChIP-Seq_BT474_Human1.13317823
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13143646
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.13143646
84NCOR_22424771_ChIP-Seq_293T_Human1.10903479
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.09191968
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09033872
87* AR_20517297_ChIP-Seq_VCAP_Human1.08304427
88ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08037244
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07782912
90* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07605839
91EZH2_27294783_Chip-Seq_NPCs_Mouse1.06530264
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06343850
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05968535
94PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04732711
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03400137
96AR_21909140_ChIP-Seq_LNCAP_Human1.03342069
97SMAD4_21799915_ChIP-Seq_A2780_Human1.03011725
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02963006
99POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01947850
100AR_25329375_ChIP-Seq_VCAP_Human1.01191509
101NFE2_27457419_Chip-Seq_LIVER_Mouse1.01142734
102CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01136365
103CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00716441
104PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00619780
105GBX2_23144817_ChIP-Seq_PC3_Human1.00612039
106ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99593504
107SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98965041
108CBX2_27304074_Chip-Seq_ESCs_Mouse0.98436455
109HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98063352
110* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97311772
111HTT_18923047_ChIP-ChIP_STHdh_Human0.97197635
112TCF4_23295773_ChIP-Seq_U87_Human0.96573754
113SOX2_16153702_ChIP-ChIP_HESCs_Human0.94647540
114SOX17_20123909_ChIP-Seq_XEN_Mouse0.94632456
115MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94395936
116STAT3_23295773_ChIP-Seq_U87_Human0.94170250
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93800249
118BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93346655
119CRX_20693478_ChIP-Seq_RETINA_Mouse0.93246578
120NOTCH1_21737748_ChIP-Seq_TLL_Human0.92501772
121CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92398857
122CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92314338
123SMAD3_21741376_ChIP-Seq_EPCs_Human0.92273228
124PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92224115
125FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88674537
126* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86953701
127CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86203960
128ZNF274_21170338_ChIP-Seq_K562_Hela0.85982933
129EWS_26573619_Chip-Seq_HEK293_Human0.85262622
130EZH2_27304074_Chip-Seq_ESCs_Mouse0.84354708
131SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82416206
132CTBP1_25329375_ChIP-Seq_LNCAP_Human0.82323197
133PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.81983911
134PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79897797
135GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79448768
136TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.78695840
137SOX2_18555785_ChIP-Seq_MESCs_Mouse0.78546978
138ZFX_18555785_ChIP-Seq_MESCs_Mouse0.78449831
139ER_23166858_ChIP-Seq_MCF-7_Human0.77746413
140RNF2_27304074_Chip-Seq_NSC_Mouse0.77496862
141SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.77280359
142REST_19997604_ChIP-ChIP_NEURONS_Mouse0.74517536
143PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.74232179
144* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.73013198
145NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.71574153
146MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.69354464
147MYC_19829295_ChIP-Seq_ESCs_Human0.68917899
148CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.67590439
149CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.67457411
150RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.67382182
151YY1_22570637_ChIP-Seq_MALME-3M_Human0.66982490
152NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.66703938

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.51297252
2MP0001529_abnormal_vocalization3.14076291
3MP0003646_muscle_fatigue2.84743605
4MP0002822_catalepsy2.66609272
5MP0009379_abnormal_foot_pigmentation2.64987056
6MP0003880_abnormal_central_pattern2.60671375
7MP0004215_abnormal_myocardial_fiber2.51433888
8MP0005257_abnormal_intraocular_pressure2.48571801
9MP0000751_myopathy2.36060298
10* MP0006036_abnormal_mitochondrial_physio2.25293427
11MP0000749_muscle_degeneration2.22798953
12MP0003136_yellow_coat_color2.20916327
13MP0003878_abnormal_ear_physiology2.13922515
14MP0005377_hearing/vestibular/ear_phenot2.13922515
15MP0006276_abnormal_autonomic_nervous2.10601541
16MP0003195_calcinosis2.07060594
17MP0004084_abnormal_cardiac_muscle2.04585605
18MP0002160_abnormal_reproductive_system2.02142398
19MP0001905_abnormal_dopamine_level2.00858679
20MP0003950_abnormal_plasma_membrane1.89592154
21MP0004036_abnormal_muscle_relaxation1.80390422
22MP0005646_abnormal_pituitary_gland1.74118964
23MP0001984_abnormal_olfaction1.71209242
24MP0004142_abnormal_muscle_tone1.66369994
25MP0003137_abnormal_impulse_conducting1.65424853
26* MP0006035_abnormal_mitochondrial_morpho1.64230201
27MP0003806_abnormal_nucleotide_metabolis1.62873575
28MP0005253_abnormal_eye_physiology1.61613504
29MP0001188_hyperpigmentation1.59998903
30MP0005330_cardiomyopathy1.57246831
31MP0008932_abnormal_embryonic_tissue1.56576064
32MP0002638_abnormal_pupillary_reflex1.50937796
33MP0003718_maternal_effect1.46456860
34MP0003941_abnormal_skin_development1.44579348
35MP0005645_abnormal_hypothalamus_physiol1.43740614
36MP0004145_abnormal_muscle_electrophysio1.43196018
37MP0005389_reproductive_system_phenotype1.38377363
38MP0008877_abnormal_DNA_methylation1.38221871
39MP0001440_abnormal_grooming_behavior1.37375478
40MP0009046_muscle_twitch1.35531006
41MP0002277_abnormal_respiratory_mucosa1.34017955
42MP0002272_abnormal_nervous_system1.32164949
43MP0004957_abnormal_blastocyst_morpholog1.30372433
44MP0000372_irregular_coat_pigmentation1.30304068
45MP0000631_abnormal_neuroendocrine_gland1.28985824
46MP0002736_abnormal_nociception_after1.28078721
47MP0008875_abnormal_xenobiotic_pharmacok1.27942569
48MP0002234_abnormal_pharynx_morphology1.27299202
49MP0002269_muscular_atrophy1.26933081
50MP0003123_paternal_imprinting1.25911348
51MP0002653_abnormal_ependyma_morphology1.25801220
52MP0008995_early_reproductive_senescence1.22961787
53MP0001485_abnormal_pinna_reflex1.20585525
54MP0003693_abnormal_embryo_hatching1.19823067
55MP0005670_abnormal_white_adipose1.19713012
56MP0002909_abnormal_adrenal_gland1.17273570
57MP0006292_abnormal_olfactory_placode1.17199791
58MP0003122_maternal_imprinting1.16550119
59MP0002972_abnormal_cardiac_muscle1.16420920
60MP0005187_abnormal_penis_morphology1.15896215
61MP0005423_abnormal_somatic_nervous1.15315551
62MP0005451_abnormal_body_composition1.15313297
63MP0001968_abnormal_touch/_nociception1.15310932
64MP0002332_abnormal_exercise_endurance1.14079983
65MP0009745_abnormal_behavioral_response1.12986460
66MP0004133_heterotaxia1.12661035
67MP0008775_abnormal_heart_ventricle1.12312409
68MP0009697_abnormal_copulation1.12304775
69MP0004147_increased_porphyrin_level1.12056285
70MP0005409_darkened_coat_color1.11185287
71MP0004043_abnormal_pH_regulation1.10920586
72MP0001929_abnormal_gametogenesis1.09708206
73MP0005620_abnormal_muscle_contractility1.09274662
74MP0006072_abnormal_retinal_apoptosis1.09199398
75MP0002102_abnormal_ear_morphology1.08909090
76MP0008058_abnormal_DNA_repair1.08129525
77MP0004085_abnormal_heartbeat1.08030985
78MP0002064_seizures1.07163887
79MP0001986_abnormal_taste_sensitivity1.06883822
80MP0000747_muscle_weakness1.05771211
81MP0000566_synostosis1.05758472
82MP0003698_abnormal_male_reproductive1.05053337
83MP0002210_abnormal_sex_determination1.03696542
84MP0002127_abnormal_cardiovascular_syste1.03129242
85MP0004924_abnormal_behavior1.03080148
86MP0005386_behavior/neurological_phenoty1.03080148
87MP0008872_abnormal_physiological_respon1.02803802
88MP0002572_abnormal_emotion/affect_behav1.02651119
89MP0001919_abnormal_reproductive_system1.01619070
90MP0004484_altered_response_of1.00986858
91MP0008260_abnormal_autophagy1.00125973
92MP0003315_abnormal_perineum_morphology1.00020147
93MP0000013_abnormal_adipose_tissue0.99566577
94MP0001970_abnormal_pain_threshold0.99310624
95MP0002106_abnormal_muscle_physiology0.97919062
96MP0005266_abnormal_metabolism0.97327959
97MP0002735_abnormal_chemical_nociception0.97092013
98MP0002734_abnormal_mechanical_nocicepti0.96474876
99MP0000750_abnormal_muscle_regeneration0.96162257
100MP0001145_abnormal_male_reproductive0.95832323
101MP0003786_premature_aging0.95198595
102MP0000653_abnormal_sex_gland0.95001501
103MP0005379_endocrine/exocrine_gland_phen0.94507266
104MP0002163_abnormal_gland_morphology0.94020283
105MP0001486_abnormal_startle_reflex0.94008320
106MP0005084_abnormal_gallbladder_morpholo0.93138382
107MP0002938_white_spotting0.92024264
108MP0001270_distended_abdomen0.91960439
109MP0006138_congestive_heart_failure0.91375785
110MP0000026_abnormal_inner_ear0.91193917
111MP0002733_abnormal_thermal_nociception0.90816602
112MP0010094_abnormal_chromosome_stability0.90480085
113MP0001727_abnormal_embryo_implantation0.90229996
114MP0002751_abnormal_autonomic_nervous0.89930694
115MP0005551_abnormal_eye_electrophysiolog0.88898305
116MP0003221_abnormal_cardiomyocyte_apopto0.88443161
117MP0005332_abnormal_amino_acid0.88411321
118MP0004130_abnormal_muscle_cell0.88125015
119MP0005636_abnormal_mineral_homeostasis0.87558640
120MP0002067_abnormal_sensory_capabilities0.86413853
121MP0004742_abnormal_vestibular_system0.86269956
122MP0005369_muscle_phenotype0.85253978
123MP0000049_abnormal_middle_ear0.84698556
124MP0001963_abnormal_hearing_physiology0.84000518
125MP0001764_abnormal_homeostasis0.83697738
126MP0005171_absent_coat_pigmentation0.82579702
127MP0002876_abnormal_thyroid_physiology0.82035993
128MP0002184_abnormal_innervation0.81799171
129MP0003938_abnormal_ear_development0.81780573
130MP0002090_abnormal_vision0.81389617
131MP0002282_abnormal_trachea_morphology0.81088971
132MP0003656_abnormal_erythrocyte_physiolo0.79016388
133MP0002928_abnormal_bile_duct0.75798920
134MP0004087_abnormal_muscle_fiber0.74985637
135MP0000759_abnormal_skeletal_muscle0.73326738
136MP0003186_abnormal_redox_activity0.73299403
137MP0005391_vision/eye_phenotype0.72450766

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.81538430
2Abnormal mitochondria in muscle tissue (HP:0008316)6.30337176
3Mitochondrial inheritance (HP:0001427)5.76034875
4Acute encephalopathy (HP:0006846)5.66330912
5Progressive macrocephaly (HP:0004481)5.62681673
6Hepatocellular necrosis (HP:0001404)5.14284816
7Increased CSF lactate (HP:0002490)5.10032991
8Hepatic necrosis (HP:0002605)4.91069039
9Increased serum pyruvate (HP:0003542)4.50881283
10Abnormality of glycolysis (HP:0004366)4.50881283
11Increased hepatocellular lipid droplets (HP:0006565)4.30246520
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.16852646
13Cerebral edema (HP:0002181)4.03070002
14Lipid accumulation in hepatocytes (HP:0006561)3.97688407
15Exercise intolerance (HP:0003546)3.88859462
16Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.83149150
17Muscle fiber inclusion bodies (HP:0100299)3.69975627
18Respiratory failure (HP:0002878)3.66998853
19Increased serum lactate (HP:0002151)3.62449841
20Lactic acidosis (HP:0003128)3.61733552
21Optic disc pallor (HP:0000543)3.53652606
22Decreased activity of mitochondrial respiratory chain (HP:0008972)3.52272321
23Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.52272321
24Nemaline bodies (HP:0003798)3.51350787
25Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.46351783
26True hermaphroditism (HP:0010459)3.41696445
27Increased intramyocellular lipid droplets (HP:0012240)3.39815777
28Leukodystrophy (HP:0002415)3.39231712
29Renal Fanconi syndrome (HP:0001994)3.38670896
30Pancreatic fibrosis (HP:0100732)3.30327135
31Pancreatic cysts (HP:0001737)3.29529418
323-Methylglutaconic aciduria (HP:0003535)3.18346341
33Increased muscle lipid content (HP:0009058)3.07332816
34Exercise-induced muscle cramps (HP:0003710)2.97176408
35Abnormality of midbrain morphology (HP:0002418)2.91397850
36Molar tooth sign on MRI (HP:0002419)2.91397850
37Oligomenorrhea (HP:0000876)2.74742742
38Ketoacidosis (HP:0001993)2.69002799
39Microvesicular hepatic steatosis (HP:0001414)2.68975452
40Palpitations (HP:0001962)2.66525414
41Congenital stationary night blindness (HP:0007642)2.62493158
42Muscle hypertrophy of the lower extremities (HP:0008968)2.60567604
43Abnormal respiratory epithelium morphology (HP:0012253)2.58602169
44Abnormal respiratory motile cilium morphology (HP:0005938)2.58602169
45Calf muscle hypertrophy (HP:0008981)2.57494125
46CNS demyelination (HP:0007305)2.56886597
47Cerebral hypomyelination (HP:0006808)2.53152258
48Type II lissencephaly (HP:0007260)2.51202168
49Distal arthrogryposis (HP:0005684)2.50978113
50Respiratory difficulties (HP:0002880)2.49922272
51Exertional dyspnea (HP:0002875)2.42947721
52Ketosis (HP:0001946)2.41108906
53Abnormality of the renal cortex (HP:0011035)2.40264552
54Absent/shortened dynein arms (HP:0200106)2.39584576
55Dynein arm defect of respiratory motile cilia (HP:0012255)2.39584576
56Abnormal ciliary motility (HP:0012262)2.39498720
57Renal cortical cysts (HP:0000803)2.37805225
58Progressive external ophthalmoplegia (HP:0000590)2.35828362
59Emotional lability (HP:0000712)2.35179710
60Ventricular tachycardia (HP:0004756)2.34374538
61Pheochromocytoma (HP:0002666)2.32992649
62Progressive inability to walk (HP:0002505)2.31212942
63Large for gestational age (HP:0001520)2.31101295
64Hyperglycinemia (HP:0002154)2.29492751
65Sudden death (HP:0001699)2.28231391
66Sclerocornea (HP:0000647)2.27276552
67Neuroendocrine neoplasm (HP:0100634)2.25472879
68Abnormal respiratory motile cilium physiology (HP:0012261)2.24856321
69Lethargy (HP:0001254)2.23994344
70Abnormality of alanine metabolism (HP:0010916)2.22044020
71Hyperalaninemia (HP:0003348)2.22044020
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22044020
73Abnormality of urine glucose concentration (HP:0011016)2.21381873
74Glycosuria (HP:0003076)2.21381873
75Hyperglycinuria (HP:0003108)2.19415952
76Hyperventilation (HP:0002883)2.19091119
77Absent rod-and cone-mediated responses on ERG (HP:0007688)2.16039426
78Abnormality of dicarboxylic acid metabolism (HP:0010995)2.16038498
79Dicarboxylic aciduria (HP:0003215)2.16038498
80X-linked dominant inheritance (HP:0001423)2.14384550
81Methylmalonic aciduria (HP:0012120)2.14051963
82Abnormality of cells of the erythroid lineage (HP:0012130)2.13232023
83Nephronophthisis (HP:0000090)2.12207221
84Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.11433540
85Pendular nystagmus (HP:0012043)2.10455929
86Abnormality of renal resorption (HP:0011038)2.10045140
87Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.09986484
88Male pseudohermaphroditism (HP:0000037)2.07939673
89Abnormality of glycine metabolism (HP:0010895)2.06152084
90Abnormality of serine family amino acid metabolism (HP:0010894)2.06152084
91Occipital encephalocele (HP:0002085)2.03090247
92Hypoplastic left heart (HP:0004383)2.02055889
93Aplasia/Hypoplasia of the tibia (HP:0005772)2.01826023
94Inability to walk (HP:0002540)2.00321152
95Hypomagnesemia (HP:0002917)1.99315454
96Cerebellar dysplasia (HP:0007033)1.98930838
97Absent phalangeal crease (HP:0006109)1.98491388
98Short tibia (HP:0005736)1.98366326
99Abnormal number of erythroid precursors (HP:0012131)1.95829990
100Methylmalonic acidemia (HP:0002912)1.93989618
101Broad-based gait (HP:0002136)1.93143680
102Rimmed vacuoles (HP:0003805)1.92832174
103Cystic liver disease (HP:0006706)1.90549270
104Abnormality of the renal medulla (HP:0100957)1.90057862
105Abolished electroretinogram (ERG) (HP:0000550)1.89259372
106Macrocytic anemia (HP:0001972)1.86154536
107Abnormal pupillary function (HP:0007686)1.85943503
108Type 2 muscle fiber atrophy (HP:0003554)1.85805801
109Generalized aminoaciduria (HP:0002909)1.83291079
110Abnormal finger flexion creases (HP:0006143)1.83284527
111Rhabdomyolysis (HP:0003201)1.83036481
112Rhinitis (HP:0012384)1.82260757
113Abnormal rod and cone electroretinograms (HP:0008323)1.81925104
114Maternal diabetes (HP:0009800)1.80507178
115Parakeratosis (HP:0001036)1.79727279
116Reticulocytopenia (HP:0001896)1.79269049
117Hypothermia (HP:0002045)1.78488568
118Malnutrition (HP:0004395)1.78351461
119Ragged-red muscle fibers (HP:0003200)1.78206941
120Concave nail (HP:0001598)1.76618416
121Congenital malformation of the right heart (HP:0011723)1.76618299
122Double outlet right ventricle (HP:0001719)1.76618299
123Medial flaring of the eyebrow (HP:0010747)1.75621943
124Abnormality of the labia minora (HP:0012880)1.75224063
125Aplasia/Hypoplasia of the tongue (HP:0010295)1.75114512
126Blindness (HP:0000618)1.74595930
127Retinal dysplasia (HP:0007973)1.74484550
128Gliosis (HP:0002171)1.73755280
129Exercise-induced myalgia (HP:0003738)1.73560837
130Congenital hepatic fibrosis (HP:0002612)1.73007935
131Hypoplastic heart (HP:0001961)1.72126551
132Proximal tubulopathy (HP:0000114)1.72066556
133Congenital ichthyosiform erythroderma (HP:0007431)1.71371389
134Abnormality of the calf musculature (HP:0001430)1.70732372
135Prostate neoplasm (HP:0100787)1.70604708
136Unsteady gait (HP:0002317)1.70065833
137Tubulointerstitial nephritis (HP:0001970)1.68467569
138Anencephaly (HP:0002323)1.68173986
139Polydipsia (HP:0001959)1.67954684
140Abnormal drinking behavior (HP:0030082)1.67954684
141Irregular epiphyses (HP:0010582)1.63714854
142Gait imbalance (HP:0002141)1.62961193
143Congenital primary aphakia (HP:0007707)1.62874046
144Carpal bone hypoplasia (HP:0001498)1.61627761
145Atrial fibrillation (HP:0005110)1.59834204
146Muscle fiber splitting (HP:0003555)1.59827160
147Breast hypoplasia (HP:0003187)1.56636023
148Congenital, generalized hypertrichosis (HP:0004540)1.56015923
149Myoglobinuria (HP:0002913)1.55159297
150Nausea (HP:0002018)1.54957884
151Vomiting (HP:0002013)1.54769127
152Supraventricular tachycardia (HP:0004755)1.53912818
153Nephrogenic diabetes insipidus (HP:0009806)1.53757271
154Birth length less than 3rd percentile (HP:0003561)1.53399214
155Vaginal atresia (HP:0000148)1.52351203
156Lipoatrophy (HP:0100578)1.52236426
157Genital tract atresia (HP:0001827)1.50389550
158Hypoplasia of the capital femoral epiphysis (HP:0003090)1.49748967
159Amniotic constriction ring (HP:0009775)1.47849954

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.95437152
2PIK3CA4.04304567
3BUB14.00906272
4NME13.79501317
5FRK3.12557096
6STK162.87827506
7CASK2.26235615
8OBSCN2.23330923
9NUAK12.10952349
10WEE12.07243460
11TRIM282.07045167
12MET1.99144571
13EIF2AK11.93347278
14MYLK1.89135868
15GRK11.82897677
16WNK31.80475103
17TAOK31.78040694
18MAPK151.75025261
19PNCK1.74853094
20MAPKAPK31.71925322
21VRK11.70839457
22MAP4K21.69947721
23TLK11.66094099
24STK391.65340433
25MAP3K21.60314624
26PBK1.56238935
27NME21.50500809
28VRK21.50242440
29TNIK1.49017587
30EIF2AK31.47404489
31MAP3K121.44542580
32PLK41.41259765
33SRPK11.41044183
34TSSK61.39722376
35CSNK1G21.34207090
36CSNK1G11.29271210
37CDK191.29145161
38ERBB31.27065907
39ZAK1.26463490
40OXSR11.24146461
41CAMK2D1.21268994
42BMPR1B1.16690345
43CCNB11.11874272
44BCKDK1.07582807
45WNK41.07510646
46NEK11.07466925
47KSR21.06227033
48IRAK21.06094879
49DYRK21.05508262
50LIMK11.05355764
51MAP2K41.05298709
52GRK71.05270360
53MUSK1.04977701
54INSRR1.04246323
55BRAF1.02826973
56PHKG11.02598069
57PHKG21.02598069
58PRKCI1.02149432
59BCR1.01577805
60ACVR1B0.99410700
61PDK40.99090233
62PDK30.99090233
63AURKA0.98575263
64AKT30.98538121
65MKNK10.96380495
66CSNK1A1L0.94756788
67PLK20.92905348
68STK38L0.90571834
69PIK3CG0.90411861
70RPS6KA40.89672757
71MAP2K20.87113012
72MST40.86434272
73PLK30.85231612
74TTK0.76559008
75MKNK20.74865216
76MAPK130.73799655
77MAP2K70.73375692
78CAMK2B0.71840020
79ADRBK20.70840870
80MAP2K10.69920947
81PLK10.69578296
82PRKCG0.69530595
83EIF2AK20.68497673
84MARK10.68212501
85CDC70.68019963
86UHMK10.67343348
87RPS6KA50.67175275
88BRSK20.66711552
89CAMK2A0.64968797
90IRAK10.63820488
91PKN10.63349349
92PDK20.62889553
93AURKB0.59237912
94ATR0.58662187
95CAMKK20.58044427
96GRK50.57169679
97CSNK2A10.57086142
98DYRK30.55053870
99LMTK20.53854158
100MAPKAPK50.53820832
101PAK30.52756138
102CDK30.51762458
103ADRBK10.51045253
104AKT20.50050226
105STK240.49785371
106PRKACB0.49633359
107PRKAA10.49610085
108CAMK2G0.49559186
109IRAK30.48274720
110CSNK2A20.47683322
111EPHA40.46169934
112CDK80.46038488
113PRKAA20.46022003
114PRKCE0.44960179
115ARAF0.43156391
116PINK10.42121446
117ILK0.41913746
118TIE10.41870314
119PRKCZ0.40959919
120ROCK20.40724283
121WNK10.40559542
122CSNK1G30.40354701
123MAP2K60.40242905
124DAPK20.40155005
125MINK10.39292855
126PRKACA0.39054154
127RPS6KB10.38720748
128NTRK30.38507605
129CSNK1E0.37366666
130ATM0.37052567
131PIM20.35728042
132MAP3K40.35677469
133RPS6KB20.34899211
134CSNK1A10.34856427
135BMPR20.34725508
136DAPK30.34376775
137NEK60.33847222
138CDK140.33155756
139ABL20.32629033

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.64897011
2Parkinsons disease_Homo sapiens_hsa050124.94065713
3Proteasome_Homo sapiens_hsa030504.17147313
4Huntingtons disease_Homo sapiens_hsa050163.66456640
5Alzheimers disease_Homo sapiens_hsa050103.59357300
6Ribosome_Homo sapiens_hsa030103.40539751
7RNA polymerase_Homo sapiens_hsa030203.11724110
8Cardiac muscle contraction_Homo sapiens_hsa042602.84883262
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.84143678
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.55531912
11Protein export_Homo sapiens_hsa030602.23522543
12Pyrimidine metabolism_Homo sapiens_hsa002401.83793355
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.79471728
14DNA replication_Homo sapiens_hsa030301.79319605
15Mismatch repair_Homo sapiens_hsa034301.78998606
16Fatty acid elongation_Homo sapiens_hsa000621.76357939
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76070210
18Spliceosome_Homo sapiens_hsa030401.72710464
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.51666733
20Nitrogen metabolism_Homo sapiens_hsa009101.51557003
21Homologous recombination_Homo sapiens_hsa034401.49378647
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44180737
23Tryptophan metabolism_Homo sapiens_hsa003801.39804647
24Propanoate metabolism_Homo sapiens_hsa006401.36447986
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34616254
26Selenocompound metabolism_Homo sapiens_hsa004501.33879127
27Collecting duct acid secretion_Homo sapiens_hsa049661.30842510
28Pyruvate metabolism_Homo sapiens_hsa006201.29628653
29Basal transcription factors_Homo sapiens_hsa030221.28051446
30Nucleotide excision repair_Homo sapiens_hsa034201.26805242
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.24464833
32RNA transport_Homo sapiens_hsa030131.23688701
33Carbon metabolism_Homo sapiens_hsa012001.19347143
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16773432
35Purine metabolism_Homo sapiens_hsa002301.15248594
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00805283
37Circadian rhythm_Homo sapiens_hsa047100.98982496
38Primary bile acid biosynthesis_Homo sapiens_hsa001200.97375644
39Base excision repair_Homo sapiens_hsa034100.93875964
40Sulfur metabolism_Homo sapiens_hsa009200.92263330
41Folate biosynthesis_Homo sapiens_hsa007900.91391514
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91277962
43* Metabolic pathways_Homo sapiens_hsa011000.91056002
44Nicotine addiction_Homo sapiens_hsa050330.89180452
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86534646
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82391640
47Butanoate metabolism_Homo sapiens_hsa006500.81964281
48Vibrio cholerae infection_Homo sapiens_hsa051100.81464296
49* Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80287603
50Chemical carcinogenesis_Homo sapiens_hsa052040.79388081
51RNA degradation_Homo sapiens_hsa030180.78205305
52Glutathione metabolism_Homo sapiens_hsa004800.76610156
53Fanconi anemia pathway_Homo sapiens_hsa034600.75760636
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74969117
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.74535677
56Mineral absorption_Homo sapiens_hsa049780.74058638
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69743768
58Olfactory transduction_Homo sapiens_hsa047400.69563169
59Non-homologous end-joining_Homo sapiens_hsa034500.68073078
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66420108
61Biosynthesis of amino acids_Homo sapiens_hsa012300.66169019
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65805975
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65509341
64Caffeine metabolism_Homo sapiens_hsa002320.65398052
65Tyrosine metabolism_Homo sapiens_hsa003500.64014107
66Vitamin B6 metabolism_Homo sapiens_hsa007500.63075643
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60860668
68Arginine and proline metabolism_Homo sapiens_hsa003300.60044364
69Phototransduction_Homo sapiens_hsa047440.58996937
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58879623
71Circadian entrainment_Homo sapiens_hsa047130.58601399
72Phenylalanine metabolism_Homo sapiens_hsa003600.58469494
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58237329
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.56481932
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56238682
76Steroid biosynthesis_Homo sapiens_hsa001000.55779853
77Sulfur relay system_Homo sapiens_hsa041220.54346434
78Cell cycle_Homo sapiens_hsa041100.53859590
79Arachidonic acid metabolism_Homo sapiens_hsa005900.51923517
80Serotonergic synapse_Homo sapiens_hsa047260.50576324
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49277551
82Fatty acid biosynthesis_Homo sapiens_hsa000610.47329068
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47053090
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46812327
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46747411
86Synaptic vesicle cycle_Homo sapiens_hsa047210.45523377
87Fatty acid metabolism_Homo sapiens_hsa012120.45224389
88Regulation of autophagy_Homo sapiens_hsa041400.44876898
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44816647
90One carbon pool by folate_Homo sapiens_hsa006700.44072021
91Fructose and mannose metabolism_Homo sapiens_hsa000510.43769451
92Pentose phosphate pathway_Homo sapiens_hsa000300.42900138
93Peroxisome_Homo sapiens_hsa041460.42549606
94Insulin secretion_Homo sapiens_hsa049110.42532918
95Oocyte meiosis_Homo sapiens_hsa041140.40899871
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39001363
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38962612
98Linoleic acid metabolism_Homo sapiens_hsa005910.37622204
99ABC transporters_Homo sapiens_hsa020100.37414278
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36869132
101Taste transduction_Homo sapiens_hsa047420.36193009
102Dilated cardiomyopathy_Homo sapiens_hsa054140.35155184
103Lysine degradation_Homo sapiens_hsa003100.34184322
104Fatty acid degradation_Homo sapiens_hsa000710.33147513
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27345478
106Epstein-Barr virus infection_Homo sapiens_hsa051690.27186101
107Ether lipid metabolism_Homo sapiens_hsa005650.26205584
108beta-Alanine metabolism_Homo sapiens_hsa004100.24675946
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23627735
110Sphingolipid metabolism_Homo sapiens_hsa006000.22403958
111Thyroid cancer_Homo sapiens_hsa052160.20602804
112GABAergic synapse_Homo sapiens_hsa047270.19237913
113Galactose metabolism_Homo sapiens_hsa000520.18454590
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.14766914
115Alcoholism_Homo sapiens_hsa050340.14729729
116Calcium signaling pathway_Homo sapiens_hsa040200.13392213
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12944421
118Rheumatoid arthritis_Homo sapiens_hsa053230.12081527
119Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.11957622
120Amphetamine addiction_Homo sapiens_hsa050310.11952087
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.11373180
122Drug metabolism - other enzymes_Homo sapiens_hsa009830.11263141
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.10793232
124Histidine metabolism_Homo sapiens_hsa003400.09102050

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