COQ9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents a mitochondrial ubiquinone biosynthesis gene. The encoded protein is likely necessary for biosynthesis of coenzyme Q10, as mutations at this locus have been associated with autosomal-recessive neonatal-onset primary coenzyme Q10 deficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tricarboxylic acid cycle (GO:0006099)6.37720466
2carnitine shuttle (GO:0006853)5.70375890
3lysine catabolic process (GO:0006554)5.68515310
4lysine metabolic process (GO:0006553)5.68515310
5fatty acid transmembrane transport (GO:1902001)5.40319851
62-oxoglutarate metabolic process (GO:0006103)5.27338068
7fatty acid beta-oxidation (GO:0006635)5.19257470
8regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.14527506
9skeletal muscle contraction (GO:0003009)5.08873377
10NADH metabolic process (GO:0006734)5.08457931
11gluconeogenesis (GO:0006094)4.84635614
12sarcomere organization (GO:0045214)4.84544131
13aspartate family amino acid catabolic process (GO:0009068)4.81623356
14branched-chain amino acid catabolic process (GO:0009083)4.70235448
15regulation of sequestering of triglyceride (GO:0010889)4.69438237
16regulation of acyl-CoA biosynthetic process (GO:0050812)4.68498205
17fatty acid oxidation (GO:0019395)4.61005347
18fatty acid catabolic process (GO:0009062)4.58780444
19succinate metabolic process (GO:0006105)4.52935272
20carnitine transmembrane transport (GO:1902603)4.52213559
21lipid oxidation (GO:0034440)4.51146887
22hexose biosynthetic process (GO:0019319)4.49377458
23response to muscle activity (GO:0014850)4.49150323
24valine metabolic process (GO:0006573)4.49104482
25oxaloacetate metabolic process (GO:0006107)4.48182373
26cellular ketone body metabolic process (GO:0046950)4.43223463
27carnitine transport (GO:0015879)4.42646251
28amino-acid betaine transport (GO:0015838)4.42646251
29acetyl-CoA metabolic process (GO:0006084)4.40062434
30branched-chain amino acid metabolic process (GO:0009081)4.38657035
31glyoxylate metabolic process (GO:0046487)4.38454510
32erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.37063583
33L-phenylalanine metabolic process (GO:0006558)4.37063583
34muscle filament sliding (GO:0030049)4.36225914
35actin-myosin filament sliding (GO:0033275)4.36225914
36erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.35706091
37L-phenylalanine catabolic process (GO:0006559)4.35706091
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.34312642
39tricarboxylic acid metabolic process (GO:0072350)4.33369285
40regulation of cofactor metabolic process (GO:0051193)4.31102703
41regulation of coenzyme metabolic process (GO:0051196)4.31102703
42short-chain fatty acid metabolic process (GO:0046459)4.30914397
43actin filament-based movement (GO:0030048)4.26527437
44cardiac myofibril assembly (GO:0055003)4.24764677
45biotin metabolic process (GO:0006768)4.18944079
46regulation of fatty acid oxidation (GO:0046320)4.14382551
47monosaccharide biosynthetic process (GO:0046364)4.13671187
48monocarboxylic acid catabolic process (GO:0072329)4.10744515
49amino-acid betaine metabolic process (GO:0006577)4.09338993
50carnitine metabolic process (GO:0009437)4.09089661
51oxidative phosphorylation (GO:0006119)4.06025345
52response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.00156294
53myofibril assembly (GO:0030239)3.97618772
54regulation of skeletal muscle contraction (GO:0014819)3.94239290
55alpha-linolenic acid metabolic process (GO:0036109)3.89102230
56kynurenine metabolic process (GO:0070189)3.88923815
57negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.87200526
58positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.86332376
59glycolytic process (GO:0006096)3.82255349
60ketone body metabolic process (GO:1902224)3.81695625
61fructose metabolic process (GO:0006000)3.76528807
62aromatic amino acid family catabolic process (GO:0009074)3.73763755
63regulation of cell communication by electrical coupling (GO:0010649)3.69748248
64regulation of triglyceride catabolic process (GO:0010896)3.68754590
65quaternary ammonium group transport (GO:0015697)3.66766173
66positive regulation of fatty acid oxidation (GO:0046321)3.63333467
67regulation of sulfur metabolic process (GO:0042762)3.62582001
68cardiac muscle contraction (GO:0060048)3.62453974
69mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.60096004
70* respiratory electron transport chain (GO:0022904)3.58539595
71regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.54897608
72triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.52007688
73actin-mediated cell contraction (GO:0070252)3.50723967
74positive regulation of fatty acid beta-oxidation (GO:0032000)3.50641880
75muscle cell cellular homeostasis (GO:0046716)3.49194641
76regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.48828189
77* electron transport chain (GO:0022900)3.48715612
78actomyosin structure organization (GO:0031032)3.48346065
79organic acid catabolic process (GO:0016054)3.41458531
80carboxylic acid catabolic process (GO:0046395)3.41458531
81glucan catabolic process (GO:0009251)3.41166396
82creatine metabolic process (GO:0006600)3.40358193
83negative regulation of potassium ion transmembrane transport (GO:1901380)3.39611577
84fatty acid homeostasis (GO:0055089)3.38845951
85cysteine metabolic process (GO:0006534)3.37230188
86ethanol oxidation (GO:0006069)3.35422526
87alpha-amino acid catabolic process (GO:1901606)3.34682694
88* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.33479986
89indole-containing compound catabolic process (GO:0042436)3.33235140
90indolalkylamine catabolic process (GO:0046218)3.33235140
91tryptophan catabolic process (GO:0006569)3.33235140
92AMP metabolic process (GO:0046033)3.32072182
93sulfur amino acid catabolic process (GO:0000098)3.30323888
94response to mercury ion (GO:0046689)3.27796631
95nucleoside diphosphate biosynthetic process (GO:0009133)3.27747890
96cellular amino acid catabolic process (GO:0009063)3.25358172
97galactose catabolic process (GO:0019388)3.24727801
98muscle contraction (GO:0006936)3.24457580
99ATP synthesis coupled proton transport (GO:0015986)3.24371561
100energy coupled proton transport, down electrochemical gradient (GO:0015985)3.24371561
101regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.18375207
102glucan biosynthetic process (GO:0009250)3.17150331
103glycogen biosynthetic process (GO:0005978)3.17150331
104bile acid biosynthetic process (GO:0006699)3.15993780
105regulation of actin filament-based movement (GO:1903115)3.15789476
106pyruvate metabolic process (GO:0006090)3.14482540
107striated muscle hypertrophy (GO:0014897)3.13754491
108regulation of relaxation of muscle (GO:1901077)3.13735785
109bundle of His cell to Purkinje myocyte communication (GO:0086069)3.12225248
110cardiac muscle hypertrophy (GO:0003300)3.11934269
111tryptophan metabolic process (GO:0006568)3.11912672
112serine family amino acid catabolic process (GO:0009071)3.11499718
113positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.10931494
114striated muscle contraction (GO:0006941)3.09013157
115plasma membrane repair (GO:0001778)3.08544432
116regulation of fatty acid beta-oxidation (GO:0031998)3.08005174
117cardiac muscle cell development (GO:0055013)3.07583208
118negative regulation of fatty acid biosynthetic process (GO:0045717)3.07316443
119sarcoplasmic reticulum calcium ion transport (GO:0070296)3.04674619
120COPI coating of Golgi vesicle (GO:0048205)3.04514159
121Golgi transport vesicle coating (GO:0048200)3.04514159
122dicarboxylic acid biosynthetic process (GO:0043650)3.03043239
123skeletal muscle fiber development (GO:0048741)3.03038384
124cellular polysaccharide catabolic process (GO:0044247)3.02554854
125acyl-CoA metabolic process (GO:0006637)3.02255247
126thioester metabolic process (GO:0035383)3.02255247
127glycogen catabolic process (GO:0005980)3.01644580
128L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.00884511
129regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.93450119
130negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.90695130
131IMP metabolic process (GO:0046040)2.89947967
132regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.87928479
133muscle system process (GO:0003012)2.87895354
134skeletal muscle adaptation (GO:0043501)2.87196152
135myotube cell development (GO:0014904)2.85933135
136negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.85568301
137response to inactivity (GO:0014854)2.84476260
1384-hydroxyproline metabolic process (GO:0019471)2.82840656
139regulation of the force of heart contraction (GO:0002026)2.82280381
140muscle cell fate commitment (GO:0042693)2.77101282
141L-methionine salvage (GO:0071267)2.75323288
142L-methionine biosynthetic process (GO:0071265)2.75323288
143amino acid salvage (GO:0043102)2.75323288
144ADP metabolic process (GO:0046031)2.74517761
145muscle hypertrophy (GO:0014896)2.73063599
146polysaccharide catabolic process (GO:0000272)2.69164228
147glucose metabolic process (GO:0006006)2.64956268
148proline biosynthetic process (GO:0006561)2.64496847
149aerobic respiration (GO:0009060)2.60940821
150glycogen metabolic process (GO:0005977)2.60401826
151adult heart development (GO:0007512)2.60305345
152regulation of striated muscle contraction (GO:0006942)2.60112085
153cardiac muscle tissue morphogenesis (GO:0055008)2.59411154

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse9.02380147
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.60760224
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.81662471
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.35619834
5* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.62194311
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.53453778
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.28996336
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.91021907
9* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.65045880
10EGR1_23403033_ChIP-Seq_LIVER_Mouse3.56205355
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.32014716
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.18947346
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.14442127
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.96432001
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.80986765
16* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.78931802
17ZNF263_19887448_ChIP-Seq_K562_Human2.34120734
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.30830608
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.28033679
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.19647073
21GATA1_22025678_ChIP-Seq_K562_Human2.19530907
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.18982144
23CLOCK_20551151_ChIP-Seq_293T_Human2.11011685
24RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08919369
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.08272862
26TBX20_22080862_ChIP-Seq_HEART_Mouse2.06972053
27TBX20_22328084_ChIP-Seq_HEART_Mouse2.06972053
28HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.92975860
29ZFX_18555785_ChIP-Seq_MESCs_Mouse1.90414124
30EP300_21415370_ChIP-Seq_HL-1_Mouse1.86592396
31ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.85951537
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80091216
33AR_21909140_ChIP-Seq_LNCAP_Human1.77329131
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.76755870
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75965537
36DCP1A_22483619_ChIP-Seq_HELA_Human1.74199711
37ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.71884481
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.70321468
39TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.69829389
40CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.66220934
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.64992092
42* XRN2_22483619_ChIP-Seq_HELA_Human1.63429274
43* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.62475296
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.55802376
45GABP_19822575_ChIP-Seq_HepG2_Human1.51635612
46PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.50291956
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.46384157
48PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.43409223
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42975371
50* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41870673
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.41606232
52* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39354687
53GATA4_21415370_ChIP-Seq_HL-1_Mouse1.37196962
54* YY1_21170310_ChIP-Seq_MESCs_Mouse1.34634458
55* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30250892
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.29165772
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28785313
58BP1_19119308_ChIP-ChIP_Hs578T_Human1.27225577
59CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27203300
60MYC_19079543_ChIP-ChIP_MESCs_Mouse1.27198291
61* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23453162
62* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.19913987
63SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.18346647
64FOXA2_19822575_ChIP-Seq_HepG2_Human1.16243311
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16161774
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16084558
67EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.14590900
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13325180
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12895093
70PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12714518
71* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12400503
72TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10583226
73SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09808095
74EST1_17652178_ChIP-ChIP_JURKAT_Human1.09727606
75* SRF_21415370_ChIP-Seq_HL-1_Mouse1.09626166
76STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08163628
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08154050
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06881819
79NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05889586
80TRIM28_21343339_ChIP-Seq_HEK293_Human1.03020884
81* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02890694
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02869003
83* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02681207
84ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00870577
85LXR_22292898_ChIP-Seq_THP-1_Human0.99210972
86* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.99045367
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98804757
88HNF4A_19822575_ChIP-Seq_HepG2_Human0.97598990
89TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96710908
90CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.96561319
91TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.96480918
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96417700
93ESR2_21235772_ChIP-Seq_MCF-7_Human0.96403882
94EOMES_21245162_ChIP-Seq_HESCs_Human0.95122282
95SOX17_20123909_ChIP-Seq_XEN_Mouse0.94973405
96CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.93294954
97E2F7_22180533_ChIP-Seq_HELA_Human0.91957394
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91789659
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91295300
100TFEB_21752829_ChIP-Seq_HELA_Human0.91277399
101TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91221708
102SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90733749
103PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90543486
104CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90159709
105HTT_18923047_ChIP-ChIP_STHdh_Human0.88817899
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88025538
107AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87812406
108TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86660735
109GATA1_19941827_ChIP-Seq_MEL_Mouse0.86590990
110BCL6_27268052_Chip-Seq_Bcells_Human0.85744491
111P68_20966046_ChIP-Seq_HELA_Human0.83022743
112LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.80981354
113RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80555964
114BCOR_27268052_Chip-Seq_Bcells_Human0.80476632
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80304101
116CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78627984
117SOX2_27498859_Chip-Seq_STOMACH_Mouse0.78458166
118TET1_21451524_ChIP-Seq_MESCs_Mouse0.76992878
119RAD21_21589869_ChIP-Seq_MESCs_Mouse0.76702333
120GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.76081075
121RXRA_24833708_ChIP-Seq_LIVER_Mouse0.75484377
122OCT4_20526341_ChIP-Seq_ESCs_Human0.75219134
123RACK7_27058665_Chip-Seq_MCF-7_Human0.72668569
124* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.72487585
125CEBPB_22108803_ChIP-Seq_LS180_Human0.72449723
126NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.72234929
127CTCF_27219007_Chip-Seq_Bcells_Human0.72124758
128FOXH1_21741376_ChIP-Seq_ESCs_Human0.71438889
129TAF2_19829295_ChIP-Seq_ESCs_Human0.71158046
130TBX5_21415370_ChIP-Seq_HL-1_Mouse0.71121166
131ERG_20517297_ChIP-Seq_VCAP_Human0.70544304
132CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.70342337
133CTCF_21964334_Chip-Seq_Bcells_Human0.70228575
134BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70216653
135PPAR_26484153_Chip-Seq_NCI-H1993_Human0.69251829
136TP63_22573176_ChIP-Seq_HFKS_Human0.68874343
137CTCF_21964334_ChIP-Seq_BJAB-B_Human0.67938032
138ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.67931774
139ATF3_27146783_Chip-Seq_COLON_Human0.67643385
140ESR1_21235772_ChIP-Seq_MCF-7_Human0.67641912
141SPI1_20517297_ChIP-Seq_HL60_Human0.67052919
142GATA1_19941826_ChIP-Seq_K562_Human0.66887718
143ELF1_20517297_ChIP-Seq_JURKAT_Human0.66046039
144RAC3_21632823_ChIP-Seq_H3396_Human0.65131204
145GATA2_19941826_ChIP-Seq_K562_Human0.64668557
146E2F1_20622854_ChIP-Seq_HELA_Human0.64280963
147AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.63899745
148YY1_22570637_ChIP-Seq_MALME-3M_Human0.63388167
149GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.62850879
150SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.62468546
151CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.62333698
152SA1_27219007_Chip-Seq_Bcells_Human0.59162175
153CSB_26484114_Chip-Seq_FIBROBLAST_Human0.57808245
154AR_20517297_ChIP-Seq_VCAP_Human0.57567798
155DNAJC2_21179169_ChIP-ChIP_NT2_Human0.57248327
156MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.56835411
157PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.56488442
158RARA_24833708_ChIP-Seq_LIVER_Mouse0.56301898
159CBP_21632823_ChIP-Seq_H3396_Human0.55876172

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.34533589
2MP0003646_muscle_fatigue4.87079866
3MP0002139_abnormal_hepatobiliary_system4.06281984
4MP0005360_urolithiasis3.84778828
5MP0000751_myopathy3.61947956
6MP0005085_abnormal_gallbladder_physiolo3.41955574
7MP0004084_abnormal_cardiac_muscle3.39583084
8MP0005365_abnormal_bile_salt3.27525267
9MP0000749_muscle_degeneration3.15321694
10MP0004130_abnormal_muscle_cell3.13142561
11MP0004036_abnormal_muscle_relaxation3.09168398
12MP0003806_abnormal_nucleotide_metabolis3.08856740
13MP0004215_abnormal_myocardial_fiber3.06016428
14MP0005330_cardiomyopathy2.88740910
15MP0006036_abnormal_mitochondrial_physio2.71863150
16MP0008875_abnormal_xenobiotic_pharmacok2.44970242
17MP0001661_extended_life_span2.41331664
18MP0004087_abnormal_muscle_fiber2.31812238
19MP0005670_abnormal_white_adipose2.30766788
20MP0005332_abnormal_amino_acid2.13828414
21MP0003195_calcinosis2.12922766
22MP0002269_muscular_atrophy2.08317334
23MP0010329_abnormal_lipoprotein_level2.08176276
24MP0003252_abnormal_bile_duct2.04522781
25MP0002972_abnormal_cardiac_muscle2.04037793
26MP0005620_abnormal_muscle_contractility2.03319939
27MP0005666_abnormal_adipose_tissue2.01806678
28MP0008775_abnormal_heart_ventricle1.95887213
29MP0004145_abnormal_muscle_electrophysio1.93419030
30MP0002106_abnormal_muscle_physiology1.91872443
31MP0009840_abnormal_foam_cell1.87946417
32MP0000747_muscle_weakness1.85766736
33MP0000750_abnormal_muscle_regeneration1.84331338
34MP0001544_abnormal_cardiovascular_syste1.79957878
35MP0005385_cardiovascular_system_phenoty1.79957878
36MP0003221_abnormal_cardiomyocyte_apopto1.71744292
37MP0006035_abnormal_mitochondrial_morpho1.71741305
38MP0010630_abnormal_cardiac_muscle1.70012447
39MP0005083_abnormal_biliary_tract1.67654953
40MP0003137_abnormal_impulse_conducting1.67396539
41MP0002118_abnormal_lipid_homeostasis1.63278135
42MP0000759_abnormal_skeletal_muscle1.58916461
43MP0002971_abnormal_brown_adipose1.57090075
44MP0006138_congestive_heart_failure1.56853741
45MP0005319_abnormal_enzyme/_coenzyme1.55974337
46MP0004484_altered_response_of1.55232104
47MP0005369_muscle_phenotype1.53174279
48MP0004043_abnormal_pH_regulation1.50314571
49MP0003191_abnormal_cellular_cholesterol1.43441648
50MP0001666_abnormal_nutrient_absorption1.42989505
51MP0005584_abnormal_enzyme/coenzyme_acti1.39969262
52MP0000733_abnormal_muscle_development1.39896684
53MP0004185_abnormal_adipocyte_glucose1.34359153
54MP0000609_abnormal_liver_physiology1.30331905
55MP0004233_abnormal_muscle_weight1.29893623
56MP0005375_adipose_tissue_phenotype1.26212313
57MP0002332_abnormal_exercise_endurance1.24280497
58MP0009643_abnormal_urine_homeostasis1.20963693
59MP0004085_abnormal_heartbeat1.19381337
60MP0005535_abnormal_body_temperature1.19340230
61MP0005266_abnormal_metabolism1.17977853
62MP0000372_irregular_coat_pigmentation1.15591287
63MP0005451_abnormal_body_composition1.13969223
64MP0002078_abnormal_glucose_homeostasis1.13562685
65MP0003656_abnormal_erythrocyte_physiolo1.12157985
66MP0003828_pulmonary_edema1.03648204
67MP0001529_abnormal_vocalization1.02656571
68MP0003186_abnormal_redox_activity1.01694767
69MP0001764_abnormal_homeostasis1.01015866
70MP0004147_increased_porphyrin_level0.99016558
71MP0004019_abnormal_vitamin_homeostasis0.94758778
72MP0000230_abnormal_systemic_arterial0.94162616
73MP0005058_abnormal_lysosome_morphology0.92788316
74MP0008260_abnormal_autophagy0.90004991
75MP0005334_abnormal_fat_pad0.89616162
76MP0003315_abnormal_perineum_morphology0.88339565
77MP0000013_abnormal_adipose_tissue0.88210828
78MP0009780_abnormal_chondrocyte_physiolo0.83925328
79MP0000343_altered_response_to0.83860476
80MP0004270_analgesia0.82466191
81MP0002127_abnormal_cardiovascular_syste0.81973261
82MP0005165_increased_susceptibility_to0.80777132
83MP0010368_abnormal_lymphatic_system0.80668993
84MP0005636_abnormal_mineral_homeostasis0.79676994
85MP0010030_abnormal_orbit_morphology0.77813431
86MP0010234_abnormal_vibrissa_follicle0.77793411
87MP0003705_abnormal_hypodermis_morpholog0.77581603
88MP0005187_abnormal_penis_morphology0.75167371
89MP0005171_absent_coat_pigmentation0.74959335
90MP0003941_abnormal_skin_development0.73611370
91MP0000003_abnormal_adipose_tissue0.72387955
92MP0003567_abnormal_fetal_cardiomyocyte0.71896963
93MP0005376_homeostasis/metabolism_phenot0.70630079
94MP0001756_abnormal_urination0.67343162
95MP0002970_abnormal_white_adipose0.67170205
96MP0002909_abnormal_adrenal_gland0.66567166
97MP0000598_abnormal_liver_morphology0.65174706
98MP0005448_abnormal_energy_balance0.64833939
99MP0002132_abnormal_respiratory_system0.63719751
100MP0002138_abnormal_hepatobiliary_system0.63662329
101MP0003868_abnormal_feces_composition0.62677028
102MP0009642_abnormal_blood_homeostasis0.62263132
103MP0000266_abnormal_heart_morphology0.61979704
104MP0009115_abnormal_fat_cell0.60977586
105MP0009672_abnormal_birth_weight0.60571147
106MP0002108_abnormal_muscle_morphology0.59676021
107MP0004510_myositis0.59499980
108MP0008932_abnormal_embryonic_tissue0.58085465
109MP0001765_abnormal_ion_homeostasis0.57480136
110MP0001727_abnormal_embryo_implantation0.57384789
111MP0009697_abnormal_copulation0.56797216
112MP0008058_abnormal_DNA_repair0.56773575
113MP0000678_abnormal_parathyroid_gland0.56638357
114MP0005408_hypopigmentation0.54478780
115MP0002822_catalepsy0.53498145
116MP0002234_abnormal_pharynx_morphology0.52294384
117MP0003959_abnormal_lean_body0.52120024
118MP0005452_abnormal_adipose_tissue0.51554242
119MP0009763_increased_sensitivity_to0.51251475
120MP0003953_abnormal_hormone_level0.49975120
121MP0001346_abnormal_lacrimal_gland0.49655513
122MP0003329_amyloid_beta_deposits0.48976538
123MP0003786_premature_aging0.47368591
124MP0008995_early_reproductive_senescence0.46845395
125MP0001984_abnormal_olfaction0.45888796
126MP0000358_abnormal_cell_content/0.44916418

Predicted human phenotypes

RankGene SetZ-score
1Myoglobinuria (HP:0002913)5.20292378
2Exercise-induced myalgia (HP:0003738)5.08391099
3Myopathic facies (HP:0002058)4.84698197
4Exercise-induced muscle cramps (HP:0003710)4.75809784
5Sudden death (HP:0001699)4.54698084
6Centrally nucleated skeletal muscle fibers (HP:0003687)4.41010249
7Hypoglycemic coma (HP:0001325)4.35064469
8Abnormality of fatty-acid metabolism (HP:0004359)4.29156449
9Calf muscle hypertrophy (HP:0008981)4.28020512
10Rhabdomyolysis (HP:0003201)4.22724053
11Ketoacidosis (HP:0001993)4.16067737
12Muscle hypertrophy of the lower extremities (HP:0008968)4.08923349
13Ketosis (HP:0001946)4.06865411
14Rimmed vacuoles (HP:0003805)4.04697600
15Ventricular tachycardia (HP:0004756)3.98156050
16Neck muscle weakness (HP:0000467)3.97907251
17Hyperglycinuria (HP:0003108)3.95835365
18Hyperammonemia (HP:0001987)3.85789632
19Abnormality of dicarboxylic acid metabolism (HP:0010995)3.83855287
20Dicarboxylic aciduria (HP:0003215)3.83855287
21Distal arthrogryposis (HP:0005684)3.81070943
22Hepatic necrosis (HP:0002605)3.80025956
23Distal lower limb muscle weakness (HP:0009053)3.72158188
24Muscle fiber splitting (HP:0003555)3.65085375
25Palpitations (HP:0001962)3.54920345
26Abnormality of glycine metabolism (HP:0010895)3.47455672
27Abnormality of serine family amino acid metabolism (HP:0010894)3.47455672
28Cerebral edema (HP:0002181)3.37986981
29Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.37937429
30Lipoatrophy (HP:0100578)3.29963411
31Generalized aminoaciduria (HP:0002909)3.25146055
32Hyporeflexia of lower limbs (HP:0002600)3.24352649
33Cholecystitis (HP:0001082)3.23385232
34Abnormal gallbladder physiology (HP:0012438)3.23385232
35Ragged-red muscle fibers (HP:0003200)3.19132691
36Acute encephalopathy (HP:0006846)3.18676487
37Abnormality of the calf musculature (HP:0001430)3.15664906
38Increased muscle lipid content (HP:0009058)3.12587483
39Abnormality of skeletal muscle fiber size (HP:0012084)3.12070482
40Abnormal mitochondria in muscle tissue (HP:0008316)3.11343639
41Right ventricular cardiomyopathy (HP:0011663)3.10040627
42EMG: myopathic abnormalities (HP:0003458)3.08860630
43Atrial fibrillation (HP:0005110)3.06822274
44Hepatocellular necrosis (HP:0001404)3.06780044
45Abnormality of aromatic amino acid family metabolism (HP:0004338)3.06385327
46Hyperglycinemia (HP:0002154)2.99703212
47Dilated cardiomyopathy (HP:0001644)2.97665689
48Asymmetric septal hypertrophy (HP:0001670)2.94992137
49Acute necrotizing encephalopathy (HP:0006965)2.91783051
50Abnormality of the left ventricular outflow tract (HP:0011103)2.91223377
51Subaortic stenosis (HP:0001682)2.91223377
52Progressive muscle weakness (HP:0003323)2.87824088
53Xanthomatosis (HP:0000991)2.87490000
54Metabolic acidosis (HP:0001942)2.83761277
55Intrahepatic cholestasis (HP:0001406)2.82471179
56Round ear (HP:0100830)2.81657976
57Primary atrial arrhythmia (HP:0001692)2.81460275
58Difficulty running (HP:0009046)2.80415254
59Increased connective tissue (HP:0009025)2.79716823
60Hypoalphalipoproteinemia (HP:0003233)2.77792225
61Muscle fiber inclusion bodies (HP:0100299)2.76834853
62Lethargy (HP:0001254)2.76344142
63* Lactic acidosis (HP:0003128)2.75965101
64Supraventricular tachycardia (HP:0004755)2.75264631
65Limb-girdle muscle atrophy (HP:0003797)2.74294551
66Bundle branch block (HP:0011710)2.72900222
67Muscle stiffness (HP:0003552)2.72315475
68Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.70264068
69Decreased activity of mitochondrial respiratory chain (HP:0008972)2.70264068
70Supraventricular arrhythmia (HP:0005115)2.68618326
71EMG: neuropathic changes (HP:0003445)2.66597859
72Gout (HP:0001997)2.65692680
73Calcaneovalgus deformity (HP:0001848)2.64699112
74Increased variability in muscle fiber diameter (HP:0003557)2.64602081
75Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.64234746
76Hyperlipoproteinemia (HP:0010980)2.63276432
77Ulnar deviation of the wrist (HP:0003049)2.59979215
78Syncope (HP:0001279)2.57204783
79Increased CSF lactate (HP:0002490)2.56740770
80Deep venous thrombosis (HP:0002625)2.56491938
81Proximal tubulopathy (HP:0000114)2.56003299
82Mitochondrial inheritance (HP:0001427)2.51319775
83Increased intramyocellular lipid droplets (HP:0012240)2.50220999
84Atrioventricular block (HP:0001678)2.49989863
85Bulbar palsy (HP:0001283)2.48086543
86Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.47922209
87Abnormality of alanine metabolism (HP:0010916)2.47922209
88Hyperalaninemia (HP:0003348)2.47922209
89Hypolipoproteinemia (HP:0010981)2.47856984
90Facial diplegia (HP:0001349)2.47723431
91Heart block (HP:0012722)2.46352836
92Myotonia (HP:0002486)2.44360340
93Abnormality of serum amino acid levels (HP:0003112)2.43336809
94Mildly elevated creatine phosphokinase (HP:0008180)2.41147143
95Ventricular arrhythmia (HP:0004308)2.39190794
96Progressive macrocephaly (HP:0004481)2.38645429
97Increased serum pyruvate (HP:0003542)2.38598145
98Abnormality of glycolysis (HP:0004366)2.38598145
99Scapular winging (HP:0003691)2.36606560
100Generalized muscle weakness (HP:0003324)2.36418304
101Deformed tarsal bones (HP:0008119)2.36295245
102Distal lower limb amyotrophy (HP:0008944)2.36118272
103Areflexia of lower limbs (HP:0002522)2.35757811
104Vomiting (HP:0002013)2.35509995
105Cholelithiasis (HP:0001081)2.35028558
106Frequent falls (HP:0002359)2.34472061
107Type 1 muscle fiber predominance (HP:0003803)2.34040871
108Nausea (HP:0002018)2.33832505
109Hyperinsulinemic hypoglycemia (HP:0000825)2.30935277
110Hypobetalipoproteinemia (HP:0003563)2.30819143
111Conjunctival hamartoma (HP:0100780)2.30318406
112Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.29243111
113Shoulder girdle muscle weakness (HP:0003547)2.28658212
114Diaphragmatic weakness (HP:0009113)2.28401371
115Abnormal atrioventricular conduction (HP:0005150)2.27482745
116Absent phalangeal crease (HP:0006109)2.25965255
117Abnormality of aspartate family amino acid metabolism (HP:0010899)2.25887869
118Difficulty climbing stairs (HP:0003551)2.24481009
119Nemaline bodies (HP:0003798)2.22768531
120Abnormal gallbladder morphology (HP:0012437)2.21542266
121Abnormality of monocarboxylic acid metabolism (HP:0010996)2.20787729
122Malignant hyperthermia (HP:0002047)2.19597650
123Abnormality of the foot musculature (HP:0001436)2.18094885
124Hyperuricemia (HP:0002149)2.17825130
125Increased purine levels (HP:0004368)2.17825130
126Abnormality of purine metabolism (HP:0004352)2.17700346
127Gowers sign (HP:0003391)2.14618244
128Exercise intolerance (HP:0003546)2.12482652
129Prolonged QT interval (HP:0001657)2.11794628
130Respiratory failure (HP:0002878)2.11668652
131Abnormality of glutamine family amino acid metabolism (HP:0010902)2.10317262
132Abnormality of the shoulder girdle musculature (HP:0001435)2.07834850
133Foot dorsiflexor weakness (HP:0009027)2.00661178
134Reduced antithrombin III activity (HP:0001976)1.95322733
135Abnormality of the hip-girdle musculature (HP:0001445)1.89241065
136Abnormality of the musculature of the pelvis (HP:0001469)1.89241065
137Spinal rigidity (HP:0003306)1.83101779
138Respiratory insufficiency due to muscle weakness (HP:0002747)1.82508081
139Pelvic girdle muscle weakness (HP:0003749)1.78131241
140Proximal amyotrophy (HP:0007126)1.77749186
141Popliteal pterygium (HP:0009756)1.75204528
142Abnormal finger flexion creases (HP:0006143)1.73939802
143Fetal akinesia sequence (HP:0001989)1.71705762
144Muscular dystrophy (HP:0003560)1.71395389
145Stridor (HP:0010307)1.71351334

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.70493005
2TTN4.54541036
3OBSCN4.30441194
4PDK44.10644604
5PDK34.10644604
6PHKG13.23169032
7PHKG23.23169032
8PKN23.13777030
9TRIB33.11411762
10LMTK23.01150822
11MYLK2.67713292
12NEK12.55004794
13PDK22.40956944
14PINK12.36136004
15TIE11.96350987
16FLT31.88444014
17EIF2AK11.87066750
18MAP2K31.79698468
19SIK11.77398181
20CCNB11.72119011
21PIK3CA1.61948679
22LIMK11.58963895
23INSRR1.58861096
24ERN11.58441322
25EEF2K1.49028188
26MUSK1.48268999
27PBK1.48241428
28BUB11.46122855
29TESK11.40989119
30PIK3CG1.35799375
31MAP3K71.34990650
32EPHA21.29124292
33DMPK1.26321101
34STK241.24251690
35WNK41.23440885
36ARAF1.17546753
37NME11.17343185
38MAP2K41.15305615
39MAPK121.14846322
40SCYL21.13871143
41FGFR41.12696431
42PRKAA21.11466552
43RIPK11.05976101
44PRKAA11.00908037
45MAPK110.95761261
46MAP3K30.94973536
47VRK20.94919709
48ICK0.93935451
49SRPK10.93629596
50STK160.87892382
51ERBB30.87739062
52GRK70.87451166
53MAPKAPK30.86725044
54TTK0.85980022
55NEK90.82774648
56STK38L0.81695162
57MAP2K60.80346819
58KDR0.77925896
59MET0.77492689
60PRKD10.77466057
61BRSK10.76522499
62ILK0.76347690
63PIM20.74312972
64EIF2AK30.73716707
65CAMK2D0.73428946
66MAP3K50.73392291
67TSSK60.67628495
68MAP3K110.67295109
69NME20.66180838
70PRKD30.66084274
71MAPKAPK50.63504291
72TGFBR20.63251066
73CSNK1G30.62943432
74CDK80.61135442
75PAK30.60967746
76PDPK10.59470365
77MARK10.59327091
78PAK40.59306045
79KSR20.57611590
80CAMK2B0.55415942
81PTK60.53825871
82WEE10.52174512
83DAPK30.51833389
84MARK30.51509791
85CAMK2G0.51157233
86PRKACG0.51028555
87PDK10.50090870
88PDGFRA0.49999538
89RPS6KB20.49814943
90LRRK20.48728765
91CAMK1D0.48718762
92CAMK40.48273200
93MAP4K20.47913160
94EPHB10.47344269
95MAP3K120.45983273
96RAF10.45189793
97ROCK20.43326534
98WNK30.43114606
99AURKB0.42596088
100ZAK0.41858085
101CSNK1G10.40792685
102ROCK10.40612806
103CSNK1G20.39660133
104SGK30.39097334
105PLK10.38835553
106MST1R0.38438416
107ABL20.37471125
108JAK20.37117297
109MOS0.36998207
110CAMK10.36568148
111AKT20.35809585
112MAP3K80.35575302
113PRKACA0.35474422
114TAOK20.34174149
115PRKACB0.34013533
116NEK20.32921886
117LATS20.31895832
118MAP3K60.31671056
119PRKG20.30701732
120PAK60.30070377
121PTK20.29910569
122AURKA0.29107063
123MAP3K10.28931316
124MAP2K10.28741299
125MAPK40.27733606
126DAPK10.27336351
127STK380.26920900
128MTOR0.26833160
129CAMK2A0.25539588
130PAK10.25418813
131JAK10.24746413
132RET0.23525155
133RPS6KL10.23215285
134RPS6KC10.23215285
135TYK20.22536687
136CDC42BPA0.21787008
137DAPK20.21636807
138PRKCH0.21448047
139SGK20.20952116
140PTK2B0.19409258
141RPS6KA60.19246881
142PKN10.18901155
143STK40.18849093
144TRPM70.18144782
145TBK10.17848848
146DYRK1B0.16589885
147RPS6KA10.14573016
148OXSR10.12687122
149SGK2230.12663809
150SGK4940.12663809
151MAPK70.12470523
152PRKCE0.12288498

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.56732773
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.81825765
3Propanoate metabolism_Homo sapiens_hsa006403.73782515
4Fatty acid degradation_Homo sapiens_hsa000713.50226678
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.42924198
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.36628251
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.88658642
8Fatty acid metabolism_Homo sapiens_hsa012122.71253025
9Carbon metabolism_Homo sapiens_hsa012002.47544958
10Pyruvate metabolism_Homo sapiens_hsa006202.37913754
11Butanoate metabolism_Homo sapiens_hsa006502.37686345
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.29335074
13Tryptophan metabolism_Homo sapiens_hsa003802.13394133
14PPAR signaling pathway_Homo sapiens_hsa033202.00032728
15Arginine biosynthesis_Homo sapiens_hsa002201.99014067
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.94165712
17Peroxisome_Homo sapiens_hsa041461.84623758
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.79653833
19Oxidative phosphorylation_Homo sapiens_hsa001901.79411485
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78858612
21Fatty acid elongation_Homo sapiens_hsa000621.75952064
22Parkinsons disease_Homo sapiens_hsa050121.74246017
23beta-Alanine metabolism_Homo sapiens_hsa004101.72071761
24Cardiac muscle contraction_Homo sapiens_hsa042601.69089601
25Nitrogen metabolism_Homo sapiens_hsa009101.68664362
26Biosynthesis of amino acids_Homo sapiens_hsa012301.61606311
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.53909959
28Starch and sucrose metabolism_Homo sapiens_hsa005001.45798335
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.43403974
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38732283
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.37931132
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.28507247
33Proteasome_Homo sapiens_hsa030501.27929879
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27420155
35Alzheimers disease_Homo sapiens_hsa050101.23298935
36Phenylalanine metabolism_Homo sapiens_hsa003601.23026212
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18434669
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18202100
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.07445961
40Selenocompound metabolism_Homo sapiens_hsa004501.06531817
41Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.05823957
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02919426
43Dilated cardiomyopathy_Homo sapiens_hsa054141.01887359
44Sulfur metabolism_Homo sapiens_hsa009201.01164644
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00072831
46Arginine and proline metabolism_Homo sapiens_hsa003300.99973327
47Complement and coagulation cascades_Homo sapiens_hsa046100.99368532
48Fat digestion and absorption_Homo sapiens_hsa049750.98663080
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.97240200
50Huntingtons disease_Homo sapiens_hsa050160.95074242
51Tyrosine metabolism_Homo sapiens_hsa003500.93902796
52Caffeine metabolism_Homo sapiens_hsa002320.90364107
53Bile secretion_Homo sapiens_hsa049760.89685658
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87223536
55Chemical carcinogenesis_Homo sapiens_hsa052040.85623979
56Fatty acid biosynthesis_Homo sapiens_hsa000610.85131744
57Histidine metabolism_Homo sapiens_hsa003400.83610923
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82462841
59Lysine degradation_Homo sapiens_hsa003100.78665120
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.78064017
61Fructose and mannose metabolism_Homo sapiens_hsa000510.77889399
62Glycerolipid metabolism_Homo sapiens_hsa005610.77389519
63Folate biosynthesis_Homo sapiens_hsa007900.75605700
64Pentose phosphate pathway_Homo sapiens_hsa000300.75531759
65Insulin resistance_Homo sapiens_hsa049310.75124561
66Galactose metabolism_Homo sapiens_hsa000520.74630274
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74626598
68Glucagon signaling pathway_Homo sapiens_hsa049220.73771099
69ABC transporters_Homo sapiens_hsa020100.70246553
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69071994
71DNA replication_Homo sapiens_hsa030300.68975510
72Sulfur relay system_Homo sapiens_hsa041220.66536905
73Steroid biosynthesis_Homo sapiens_hsa001000.64184995
74Base excision repair_Homo sapiens_hsa034100.63575553
75Metabolic pathways_Homo sapiens_hsa011000.61751495
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.58679568
77Retinol metabolism_Homo sapiens_hsa008300.57922090
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.53498433
79Insulin signaling pathway_Homo sapiens_hsa049100.52112327
80AMPK signaling pathway_Homo sapiens_hsa041520.52066259
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51796907
82Glutathione metabolism_Homo sapiens_hsa004800.47845544
83Purine metabolism_Homo sapiens_hsa002300.47344950
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46320521
85Pyrimidine metabolism_Homo sapiens_hsa002400.45334647
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43025287
87Mismatch repair_Homo sapiens_hsa034300.42609437
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.40834275
89Nucleotide excision repair_Homo sapiens_hsa034200.36435687
90Vitamin digestion and absorption_Homo sapiens_hsa049770.35819658
91Vitamin B6 metabolism_Homo sapiens_hsa007500.35136929
92N-Glycan biosynthesis_Homo sapiens_hsa005100.32229389
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32174679
94Staphylococcus aureus infection_Homo sapiens_hsa051500.29631414
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.27561552
96Oocyte meiosis_Homo sapiens_hsa041140.27462277
97Tight junction_Homo sapiens_hsa045300.27214334
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.21215392
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20094286
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19743546
101Other glycan degradation_Homo sapiens_hsa005110.19136679
102Vibrio cholerae infection_Homo sapiens_hsa051100.18924720
103Mineral absorption_Homo sapiens_hsa049780.15571140
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.14994101
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.13893633
106Viral myocarditis_Homo sapiens_hsa054160.10764880
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.09837240
108Circadian rhythm_Homo sapiens_hsa047100.07206561
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.07121472
110Linoleic acid metabolism_Homo sapiens_hsa005910.07055946
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.06098736
112Regulation of autophagy_Homo sapiens_hsa041400.01993611
113One carbon pool by folate_Homo sapiens_hsa00670-0.0822659
114Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.0687111
115Type II diabetes mellitus_Homo sapiens_hsa04930-0.0470027
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0296093
117Calcium signaling pathway_Homo sapiens_hsa04020-0.0186392
118HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0114242

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