CORIN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)7.27264270
2sarcomere organization (GO:0045214)6.64692206
3regulation of branching involved in prostate gland morphogenesis (GO:0060687)6.41855301
4adult heart development (GO:0007512)6.25121735
5regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.13076445
6myofibril assembly (GO:0030239)6.08405176
7negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.91867588
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.59571940
9regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.56951199
10regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.56406065
11negative regulation of potassium ion transmembrane transport (GO:1901380)5.40134773
12lateral sprouting from an epithelium (GO:0060601)5.09259060
13cardiac muscle contraction (GO:0060048)5.05358739
14cardiac muscle hypertrophy (GO:0003300)4.92875230
15prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.92731240
16mesenchymal-epithelial cell signaling (GO:0060638)4.90816178
17regulation of relaxation of muscle (GO:1901077)4.87657847
18cardiac muscle cell development (GO:0055013)4.85811561
19tricarboxylic acid cycle (GO:0006099)4.85484601
20regulation of actin filament-based movement (GO:1903115)4.84485155
21heart trabecula formation (GO:0060347)4.68474444
22ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.67636254
23striated muscle hypertrophy (GO:0014897)4.62448738
24cardiac cell development (GO:0055006)4.60549131
25regulation of sarcomere organization (GO:0060297)4.60377378
26cardiac muscle tissue morphogenesis (GO:0055008)4.59034131
27bundle of His cell to Purkinje myocyte communication (GO:0086069)4.53469115
28ventricular cardiac muscle cell action potential (GO:0086005)4.50507184
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.38309874
30cardiac chamber formation (GO:0003207)4.37879988
31regulation of cell communication by electrical coupling (GO:0010649)4.36409088
32branching involved in salivary gland morphogenesis (GO:0060445)4.34621143
33neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)4.34202829
34cell proliferation involved in metanephros development (GO:0072203)4.32194812
35actomyosin structure organization (GO:0031032)4.24660795
36trabecula formation (GO:0060343)4.24424371
37positive regulation of heart rate (GO:0010460)4.21736289
38regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.15274029
39carnitine shuttle (GO:0006853)4.12011500
40muscle tissue morphogenesis (GO:0060415)4.07446287
41cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.07439297
42regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.05562606
43muscle hypertrophy (GO:0014896)4.04945909
44muscle filament sliding (GO:0030049)4.04725623
45actin-myosin filament sliding (GO:0033275)4.04725623
46cell communication involved in cardiac conduction (GO:0086065)4.02798695
47bone trabecula formation (GO:0060346)4.01452481
48adrenergic receptor signaling pathway (GO:0071875)3.97473680
49negative regulation of cytosolic calcium ion concentration (GO:0051481)3.93863449
50otic vesicle formation (GO:0030916)3.89847386
51regulation of striated muscle contraction (GO:0006942)3.89119355
52cardiac ventricle formation (GO:0003211)3.86582182
53regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.83232927
54regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.82953872
55plasma membrane repair (GO:0001778)3.81897288
56cell proliferation involved in kidney development (GO:0072111)3.81854023
57response to caffeine (GO:0031000)3.74025749
58cardiac muscle adaptation (GO:0014887)3.70906639
59cardiac muscle hypertrophy in response to stress (GO:0014898)3.70906639
60muscle hypertrophy in response to stress (GO:0003299)3.70906639
61positive regulation of heart contraction (GO:0045823)3.70621221
62regulation of cardiac muscle cell contraction (GO:0086004)3.67642265
63fatty acid transmembrane transport (GO:1902001)3.67331513
64regulation of cardiac muscle contraction (GO:0055117)3.62581003
65negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.61045950
66somite development (GO:0061053)3.58332928
67radial glial cell differentiation (GO:0060019)3.55646528
68regulation of cardioblast differentiation (GO:0051890)3.53845577
69regulation of skeletal muscle contraction (GO:0014819)3.53487590
70striated muscle contraction (GO:0006941)3.52880994
71mesenchymal cell proliferation (GO:0010463)3.50403455
72positive regulation of action potential (GO:0045760)3.50275587
73cell communication by electrical coupling (GO:0010644)3.48438835
74actin-mediated cell contraction (GO:0070252)3.47615945
75behavioral response to nicotine (GO:0035095)3.46941423
76regulation of the force of heart contraction (GO:0002026)3.43947738
77regulation of acyl-CoA biosynthetic process (GO:0050812)3.43921900
78branching involved in labyrinthine layer morphogenesis (GO:0060670)3.43685846
79regulation of heart rate (GO:0002027)3.42841809
80detection of calcium ion (GO:0005513)3.38960014
81keratinocyte proliferation (GO:0043616)3.37613517
82regulation of membrane repolarization (GO:0060306)3.37367747
83negative regulation of heart rate (GO:0010459)3.35163575
84craniofacial suture morphogenesis (GO:0097094)3.35147359
85negative regulation of striated muscle cell apoptotic process (GO:0010664)3.33915789
86sarcoplasmic reticulum calcium ion transport (GO:0070296)3.31865042
87relaxation of cardiac muscle (GO:0055119)3.30170442
88heart morphogenesis (GO:0003007)3.23788815
892-oxoglutarate metabolic process (GO:0006103)3.23053611
90positive regulation of cardiac muscle cell differentiation (GO:2000727)3.22533051
91positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.22274827
92negative regulation of osteoblast proliferation (GO:0033689)3.20491975
93planar cell polarity pathway involved in neural tube closure (GO:0090179)3.19681551
94response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.17087983
95cardiac conduction (GO:0061337)3.14777822
96cardiac muscle cell action potential (GO:0086001)3.14730087
97branching involved in prostate gland morphogenesis (GO:0060442)3.13212416
98cardiac muscle cell action potential involved in contraction (GO:0086002)3.11063690
99artery smooth muscle contraction (GO:0014824)3.09679960
100desmosome organization (GO:0002934)3.06942398
101regulation of coenzyme metabolic process (GO:0051196)3.06412422
102regulation of cofactor metabolic process (GO:0051193)3.06412422
103positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.06219386
104ventricular cardiac muscle cell development (GO:0055015)3.05845585
105heart process (GO:0003015)3.05830457
106heart contraction (GO:0060047)3.05830457
107carnitine transmembrane transport (GO:1902603)3.05079747
108relaxation of muscle (GO:0090075)3.04524397
109regulation of heart contraction (GO:0008016)3.04222288
110outflow tract septum morphogenesis (GO:0003148)3.01582744
111regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.00508238
112atrial septum morphogenesis (GO:0060413)2.99641574
113regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.96715976
114regulation of ATPase activity (GO:0043462)2.96460817
115regulation of ATP catabolic process (GO:1903289)2.96460817
116regulation of non-canonical Wnt signaling pathway (GO:2000050)2.94868681
117cellular ketone body metabolic process (GO:0046950)2.93918448
118kynurenine metabolic process (GO:0070189)2.93607068
119positive regulation of ATPase activity (GO:0032781)2.93598765
120positive regulation of ATP catabolic process (GO:1903291)2.93598765
121relaxation of smooth muscle (GO:0044557)2.89481314
122detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.87589840
123negative regulation of systemic arterial blood pressure (GO:0003085)2.82567637
124regulation of action potential (GO:0098900)2.80994734
125membrane depolarization during action potential (GO:0086010)2.80861505
126cardiac muscle tissue development (GO:0048738)2.73923104
127indole-containing compound catabolic process (GO:0042436)2.73860206
128indolalkylamine catabolic process (GO:0046218)2.73860206
129tryptophan catabolic process (GO:0006569)2.73860206
130negative regulation of calcium ion transmembrane transport (GO:1903170)2.72188627
131negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.72188627
132action potential (GO:0001508)2.70764137
133neuronal action potential (GO:0019228)2.70077500
134response to inactivity (GO:0014854)2.69920181
135indolalkylamine metabolic process (GO:0006586)2.67745032
136cardiac right ventricle morphogenesis (GO:0003215)2.66589826
137regulation of muscle contraction (GO:0006937)2.65772426
138positive regulation of sodium ion transmembrane transport (GO:1902307)2.61003756
139regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.60924381
140multicellular organismal signaling (GO:0035637)2.59346720
141inner ear receptor stereocilium organization (GO:0060122)2.59269961
142positive regulation of sodium ion transport (GO:0010765)2.58420832
143striated muscle cell development (GO:0055002)2.58368949
144ketone body metabolic process (GO:1902224)2.58325485

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.09418396
2EP300_21415370_ChIP-Seq_HL-1_Mouse4.03465229
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.92101150
4CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.27568620
5* TBX20_22080862_ChIP-Seq_HEART_Mouse2.77972991
6* TBX20_22328084_ChIP-Seq_HEART_Mouse2.77972991
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.74630254
8ZNF274_21170338_ChIP-Seq_K562_Hela2.72994533
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.69708682
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.64818148
11EZH2_22144423_ChIP-Seq_EOC_Human2.63178726
12ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.57209044
13* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.45988061
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.40639180
15EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.33652462
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.19501438
17TAF15_26573619_Chip-Seq_HEK293_Human2.17980495
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13904299
19IGF1R_20145208_ChIP-Seq_DFB_Human2.07733917
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03093485
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00241573
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.00177474
23P300_19829295_ChIP-Seq_ESCs_Human1.99059693
24* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.98182457
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.97069204
26FUS_26573619_Chip-Seq_HEK293_Human1.94997592
27EWS_26573619_Chip-Seq_HEK293_Human1.92051721
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.87170684
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86336686
30ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.86074649
31ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.82685181
32* EED_16625203_ChIP-ChIP_MESCs_Mouse1.74495772
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73632602
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72686900
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70955545
36ER_23166858_ChIP-Seq_MCF-7_Human1.68577517
37* STAT3_23295773_ChIP-Seq_U87_Human1.67065975
38ISL1_27105846_Chip-Seq_CPCs_Mouse1.66553357
39SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.65168387
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64840959
41* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.62155110
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60576083
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.60288478
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.60288478
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57567707
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.56692654
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.56551202
48* TCF4_23295773_ChIP-Seq_U87_Human1.55382221
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.55225868
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.52442470
51AHR_22903824_ChIP-Seq_MCF-7_Human1.51929567
52* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.51476202
53DROSHA_22980978_ChIP-Seq_HELA_Human1.50883168
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49930687
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49777628
56ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.49664097
57TRIM28_21343339_ChIP-Seq_HEK293_Human1.49630423
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.49254993
59NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.47610991
60BCAT_22108803_ChIP-Seq_LS180_Human1.47192848
61* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45775600
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.45634948
63CTNNB1_20460455_ChIP-Seq_HCT116_Human1.45592061
64* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.44356745
65* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.44012645
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.43915356
67TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.43729905
68AR_21572438_ChIP-Seq_LNCaP_Human1.43649220
69* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43582077
70* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.40950945
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40193139
72* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.39446517
73* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.39372569
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38906456
75* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37856059
76* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37856059
77* AR_25329375_ChIP-Seq_VCAP_Human1.34869761
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.34578285
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.34417319
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32715368
81LXR_22158963_ChIP-Seq_LIVER_Mouse1.31905282
82WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31655473
83TCF4_22108803_ChIP-Seq_LS180_Human1.31365342
84* SMAD4_21799915_ChIP-Seq_A2780_Human1.30926192
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30491367
86* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.28633080
87NANOG_19829295_ChIP-Seq_ESCs_Human1.27115015
88SOX2_19829295_ChIP-Seq_ESCs_Human1.27115015
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26998575
90CBP_20019798_ChIP-Seq_JUKART_Human1.25952433
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25952433
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.25761363
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25486476
94GBX2_23144817_ChIP-Seq_PC3_Human1.23619596
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23319249
96STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.23073447
97* SOX2_21211035_ChIP-Seq_LN229_Gbm1.22699261
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.22158804
99RUNX2_22187159_ChIP-Seq_PCA_Human1.21860758
100* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.21376941
101VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21329857
102RNF2_27304074_Chip-Seq_ESCs_Mouse1.21093426
103* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19850363
104GATA1_22025678_ChIP-Seq_K562_Human1.19314646
105JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19300412
106* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19029868
107EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18816529
108BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18788094
109TP53_16413492_ChIP-PET_HCT116_Human1.18595559
110EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18293652
111* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18207459
112NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17926089
113SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16736094
114CRX_20693478_ChIP-Seq_RETINA_Mouse1.15014889
115MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14583198
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14422957
117CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14310798
118P53_22387025_ChIP-Seq_ESCs_Mouse1.12763385
119E2F1_18555785_Chip-Seq_ESCs_Mouse1.12718913
120RNF2_27304074_Chip-Seq_NSC_Mouse1.12584175
121SMAD4_21741376_ChIP-Seq_HESCs_Human1.11770668
122SMAD4_21741376_ChIP-Seq_EPCs_Human1.11721943
123PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11661337
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11527581
125NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11255130
126NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11255130
127FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09957450
128CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08782596
129ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08379963
130CJUN_26792858_Chip-Seq_BT549_Human1.06177668
131* FOXA2_19822575_ChIP-Seq_HepG2_Human1.05969932
132FLI1_21867929_ChIP-Seq_TH2_Mouse1.05862058
133PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05815656
134CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05768434
135TBL1_22424771_ChIP-Seq_293T_Human1.05748481
136KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05561737
137PRDM14_20953172_ChIP-Seq_ESCs_Human1.04285332
138TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04202328
139DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04166192
140TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03983611
141PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02951232
142CDX2_22108803_ChIP-Seq_LS180_Human1.02061166
143LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01900344
144SMAD3_21741376_ChIP-Seq_HESCs_Human1.01276041
145TAL1_26923725_Chip-Seq_HPCs_Mouse1.00807012
146TP53_22573176_ChIP-Seq_HFKS_Human1.00650403
147STAT3_18555785_Chip-Seq_ESCs_Mouse1.00279039
148VDR_22108803_ChIP-Seq_LS180_Human1.00164011
149ESR1_21235772_ChIP-Seq_MCF-7_Human0.98602327
150FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98565092
151* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98224667
152AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98054050
153ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97534960
154OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97289358
155YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96952873
156WT1_19549856_ChIP-ChIP_CCG9911_Human0.96572583
157GATA2_21666600_ChIP-Seq_HMVEC_Human0.96464783
158ZNF263_19887448_ChIP-Seq_K562_Human0.96351586
159PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94638499
160TCF4_18268006_ChIP-ChIP_LS174T_Human0.94134083
161HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93281939
162* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92171604
163SMAD3_21741376_ChIP-Seq_EPCs_Human0.91830705
164TP53_20018659_ChIP-ChIP_R1E_Mouse0.90899531
165RXR_22108803_ChIP-Seq_LS180_Human0.90544106
166TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89876103
167RING1B_27294783_Chip-Seq_ESCs_Mouse0.89301148

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.91800692
2MP0000751_myopathy5.11419385
3MP0004084_abnormal_cardiac_muscle5.09036479
4MP0004215_abnormal_myocardial_fiber4.33466650
5MP0003646_muscle_fatigue4.25229768
6MP0008775_abnormal_heart_ventricle3.71180884
7MP0004036_abnormal_muscle_relaxation3.48140237
8MP0005330_cardiomyopathy3.38097625
9MP0005187_abnormal_penis_morphology3.14210781
10* MP0002972_abnormal_cardiac_muscle2.72592973
11MP0000750_abnormal_muscle_regeneration2.71412087
12MP0004087_abnormal_muscle_fiber2.68798293
13MP0000749_muscle_degeneration2.63187309
14MP0010630_abnormal_cardiac_muscle2.58790965
15MP0003137_abnormal_impulse_conducting2.55557820
16MP0001544_abnormal_cardiovascular_syste2.36891083
17MP0005385_cardiovascular_system_phenoty2.36891083
18MP0005503_abnormal_tendon_morphology2.18710017
19MP0004272_abnormal_basement_membrane2.15799026
20MP0004130_abnormal_muscle_cell2.15506427
21* MP0005620_abnormal_muscle_contractility2.10395047
22MP0006138_congestive_heart_failure2.05091138
23MP0002938_white_spotting1.99764693
24MP0010368_abnormal_lymphatic_system1.98127107
25MP0004484_altered_response_of1.98043365
26MP0004085_abnormal_heartbeat1.94710958
27MP0003828_pulmonary_edema1.91025023
28MP0002106_abnormal_muscle_physiology1.90007025
29MP0001299_abnormal_eye_distance/1.88323717
30MP0001661_extended_life_span1.86072493
31MP0000566_synostosis1.82773095
32MP0002269_muscular_atrophy1.81401095
33MP0005369_muscle_phenotype1.77393692
34MP0001986_abnormal_taste_sensitivity1.76225493
35MP0002108_abnormal_muscle_morphology1.70314205
36MP0005551_abnormal_eye_electrophysiolog1.64599599
37MP0000569_abnormal_digit_pigmentation1.48944397
38MP0003195_calcinosis1.48193556
39MP0006072_abnormal_retinal_apoptosis1.46497526
40MP0004145_abnormal_muscle_electrophysio1.42649227
41MP0000747_muscle_weakness1.40582636
42MP0000428_abnormal_craniofacial_morphol1.40128187
43MP0000759_abnormal_skeletal_muscle1.37948499
44MP0005248_abnormal_Harderian_gland1.36781787
45MP0001984_abnormal_olfaction1.36513083
46MP0003283_abnormal_digestive_organ1.36030339
47MP0002127_abnormal_cardiovascular_syste1.35082853
48MP0004233_abnormal_muscle_weight1.32641672
49MP0009745_abnormal_behavioral_response1.29251867
50MP0000579_abnormal_nail_morphology1.28727246
51MP0003567_abnormal_fetal_cardiomyocyte1.28318939
52MP0005253_abnormal_eye_physiology1.26980466
53MP0009046_muscle_twitch1.26545551
54MP0004510_myositis1.26230509
55MP0003136_yellow_coat_color1.24631899
56* MP0000266_abnormal_heart_morphology1.20214265
57MP0004142_abnormal_muscle_tone1.17800645
58MP0003221_abnormal_cardiomyocyte_apopto1.17380609
59MP0003279_aneurysm1.15442155
60MP0001968_abnormal_touch/_nociception1.14991497
61MP0004147_increased_porphyrin_level1.13553733
62MP0005666_abnormal_adipose_tissue1.13280726
63MP0009250_abnormal_appendicular_skeleto1.12560072
64MP0000343_altered_response_to1.11979022
65MP0008877_abnormal_DNA_methylation1.10339499
66MP0002272_abnormal_nervous_system1.10259524
67MP0002735_abnormal_chemical_nociception1.10229729
68MP0001501_abnormal_sleep_pattern1.09956440
69MP0001293_anophthalmia1.08370368
70MP0006036_abnormal_mitochondrial_physio1.05173249
71MP0005171_absent_coat_pigmentation1.03402778
72MP0002638_abnormal_pupillary_reflex1.01676968
73MP0005670_abnormal_white_adipose1.01367875
74MP0006276_abnormal_autonomic_nervous0.99887784
75MP0002876_abnormal_thyroid_physiology0.99004519
76MP0000537_abnormal_urethra_morphology0.97789372
77MP0002282_abnormal_trachea_morphology0.97412022
78MP0001485_abnormal_pinna_reflex0.96764392
79MP0005386_behavior/neurological_phenoty0.95753819
80MP0004924_abnormal_behavior0.95753819
81MP0001486_abnormal_startle_reflex0.94231511
82MP0002736_abnormal_nociception_after0.87536534
83MP0002295_abnormal_pulmonary_circulatio0.87284072
84MP0003880_abnormal_central_pattern0.87204953
85MP0002128_abnormal_blood_circulation0.84872731
86MP0003950_abnormal_plasma_membrane0.83878390
87MP0000383_abnormal_hair_follicle0.83691079
88MP0001529_abnormal_vocalization0.83550419
89MP0002234_abnormal_pharynx_morphology0.82648281
90MP0010030_abnormal_orbit_morphology0.81833653
91MP0003935_abnormal_craniofacial_develop0.81487428
92MP0005375_adipose_tissue_phenotype0.81293046
93MP0010386_abnormal_urinary_bladder0.80724822
94MP0003942_abnormal_urinary_system0.78431770
95MP0004043_abnormal_pH_regulation0.78258049
96MP0008872_abnormal_physiological_respon0.77490984
97MP0000538_abnormal_urinary_bladder0.76208419
98MP0000767_abnormal_smooth_muscle0.75011564
99MP0003385_abnormal_body_wall0.74243315
100MP0005084_abnormal_gallbladder_morpholo0.74058946
101MP0002064_seizures0.73691481
102MP0003011_delayed_dark_adaptation0.73533167
103MP0000631_abnormal_neuroendocrine_gland0.73136995
104MP0000372_irregular_coat_pigmentation0.72777425
105MP0003705_abnormal_hypodermis_morpholog0.72209700
106MP0003787_abnormal_imprinting0.70777881
107MP0005646_abnormal_pituitary_gland0.70638300
108MP0004885_abnormal_endolymph0.70126720
109MP0002067_abnormal_sensory_capabilities0.69304591
110MP0001970_abnormal_pain_threshold0.68785455
111MP0002572_abnormal_emotion/affect_behav0.68755494
112MP0005595_abnormal_vascular_smooth0.67552079
113MP0002925_abnormal_cardiovascular_devel0.66663096
114MP0000647_abnormal_sebaceous_gland0.65557656
115MP0000026_abnormal_inner_ear0.65215342
116MP0008438_abnormal_cutaneous_collagen0.64378847
117MP0000778_abnormal_nervous_system0.63783565
118* MP0000427_abnormal_hair_cycle0.63132261
119MP0002332_abnormal_exercise_endurance0.62598947
120MP0002168_other_aberrant_phenotype0.62516075
121MP0005085_abnormal_gallbladder_physiolo0.61123333
122MP0000733_abnormal_muscle_development0.60862443
123MP0005165_increased_susceptibility_to0.60251558
124MP0005266_abnormal_metabolism0.60123455
125MP0003119_abnormal_digestive_system0.60036254
126MP0005645_abnormal_hypothalamus_physiol0.59914939
127MP0004134_abnormal_chest_morphology0.59908957
128MP0004133_heterotaxia0.58806427
129MP0002751_abnormal_autonomic_nervous0.58804836
130MP0000003_abnormal_adipose_tissue0.58520069
131MP0009384_cardiac_valve_regurgitation0.58286500
132MP0005508_abnormal_skeleton_morphology0.57820208
133MP0004185_abnormal_adipocyte_glucose0.57592703
134MP0002896_abnormal_bone_mineralization0.56786400
135MP0002088_abnormal_embryonic_growth/wei0.56440162
136MP0003566_abnormal_cell_adhesion0.56193075
137MP0005257_abnormal_intraocular_pressure0.54521839
138MP0002116_abnormal_craniofacial_bone0.53167615
139MP0000462_abnormal_digestive_system0.52293706
140MP0000762_abnormal_tongue_morphology0.52289849
141MP0005220_abnormal_exocrine_pancreas0.51802211
142MP0003984_embryonic_growth_retardation0.51186546
143MP0005075_abnormal_melanosome_morpholog0.49330117
144MP0002102_abnormal_ear_morphology0.47193155
145* MP0000230_abnormal_systemic_arterial0.47082840
146MP0009780_abnormal_chondrocyte_physiolo0.46597507
147MP0002971_abnormal_brown_adipose0.45338004
148MP0003252_abnormal_bile_duct0.44913894
149MP0005275_abnormal_skin_tensile0.44684754
150MP0001879_abnormal_lymphatic_vessel0.43970589
151MP0001614_abnormal_blood_vessel0.43147051
152MP0003937_abnormal_limbs/digits/tail_de0.41940068

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.72931809
2Ventricular tachycardia (HP:0004756)5.52059859
3Abnormality of the parietal bone (HP:0002696)5.36224203
4Atrial fibrillation (HP:0005110)5.08992467
5Calf muscle hypertrophy (HP:0008981)4.84454959
6Midline defect of the nose (HP:0004122)4.82283327
7Primary atrial arrhythmia (HP:0001692)4.77790577
8Supraventricular tachycardia (HP:0004755)4.58225149
9Supraventricular arrhythmia (HP:0005115)4.48588036
10Short 4th metacarpal (HP:0010044)4.33650610
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.33650610
12Lipoatrophy (HP:0100578)4.26716349
13Broad metatarsal (HP:0001783)4.24986155
14Muscle hypertrophy of the lower extremities (HP:0008968)4.24843218
15Right ventricular cardiomyopathy (HP:0011663)4.18020671
16Syncope (HP:0001279)4.10779514
17Abnormality of the calf musculature (HP:0001430)4.02070184
18Subaortic stenosis (HP:0001682)3.88950966
19Abnormality of the left ventricular outflow tract (HP:0011103)3.88950966
20Abnormality of the 4th metacarpal (HP:0010012)3.81298976
21Pancreatic cysts (HP:0001737)3.76189331
22Trigonocephaly (HP:0000243)3.76126278
23Muscle fiber splitting (HP:0003555)3.70086155
24Exercise-induced myalgia (HP:0003738)3.69556200
25Hyporeflexia of lower limbs (HP:0002600)3.64769805
26Prolonged QT interval (HP:0001657)3.59762163
27Exercise-induced muscle cramps (HP:0003710)3.58413992
28Bundle branch block (HP:0011710)3.55095836
29Pancreatic fibrosis (HP:0100732)3.48927578
30Myoglobinuria (HP:0002913)3.44039742
31Dilated cardiomyopathy (HP:0001644)3.38943275
32Neoplasm of the heart (HP:0100544)3.29796520
33True hermaphroditism (HP:0010459)3.28430365
34Nasolacrimal duct obstruction (HP:0000579)3.27333969
35Depressed nasal tip (HP:0000437)3.20431027
36Palpitations (HP:0001962)3.19871893
37Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.17586343
38Hypoplastic ischia (HP:0003175)3.16049175
39Ventricular arrhythmia (HP:0004308)3.15410704
40Abnormality of the renal cortex (HP:0011035)3.14385586
41Nephronophthisis (HP:0000090)3.09619051
42Abnormality of midbrain morphology (HP:0002418)3.06201820
43Molar tooth sign on MRI (HP:0002419)3.06201820
44Heart block (HP:0012722)2.93545839
45Chronic hepatic failure (HP:0100626)2.93450398
46Atrioventricular block (HP:0001678)2.91277291
47Abnormality of the diencephalon (HP:0010662)2.88844741
48Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.88202825
49Abnormality of the ischium (HP:0003174)2.80981657
50Abnormality of the renal medulla (HP:0100957)2.78065095
51Exostoses (HP:0100777)2.76804948
52Ventricular fibrillation (HP:0001663)2.76786418
53Congenital stationary night blindness (HP:0007642)2.75493070
54Hyperventilation (HP:0002883)2.75027943
55Type II lissencephaly (HP:0007260)2.74005411
56Abnormal atrioventricular conduction (HP:0005150)2.72510061
57Anteriorly placed anus (HP:0001545)2.69415863
58Aplasia cutis congenita (HP:0001057)2.63205367
59Abnormality of the lacrimal duct (HP:0011481)2.60138385
60Shallow orbits (HP:0000586)2.58067802
61Asymmetric septal hypertrophy (HP:0001670)2.55139139
62Renal cortical cysts (HP:0000803)2.54519338
63Broad face (HP:0000283)2.54247053
64Attenuation of retinal blood vessels (HP:0007843)2.49987636
65EMG: myopathic abnormalities (HP:0003458)2.47206045
66Increased connective tissue (HP:0009025)2.44138070
67Abnormal EKG (HP:0003115)2.41369805
68Alacrima (HP:0000522)2.41262927
69Abnormality of the nasal septum (HP:0000419)2.38730757
70Abnormality of the nasolacrimal system (HP:0000614)2.38101178
71Tubular atrophy (HP:0000092)2.37845381
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.36875060
73Abnormality of alanine metabolism (HP:0010916)2.36875060
74Hyperalaninemia (HP:0003348)2.36875060
75Cystic liver disease (HP:0006706)2.36190913
76Bradycardia (HP:0001662)2.35783561
77Medial flaring of the eyebrow (HP:0010747)2.33199405
78Short phalanx of the thumb (HP:0009660)2.32622654
79Hypoglycemic coma (HP:0001325)2.29724513
80Keratoconus (HP:0000563)2.29527068
81Increased corneal curvature (HP:0100692)2.29527068
82Abnormality of the salivary glands (HP:0010286)2.26944936
83Myotonia (HP:0002486)2.26768087
84Rhabdomyolysis (HP:0003201)2.25910026
85Palmoplantar keratoderma (HP:0000982)2.23272342
86Aplasia involving bones of the upper limbs (HP:0009823)2.23073313
87Aplasia of the phalanges of the hand (HP:0009802)2.23073313
88Aplasia involving bones of the extremities (HP:0009825)2.23073313
89Ketoacidosis (HP:0001993)2.21295031
90Gaze-evoked nystagmus (HP:0000640)2.19182008
91Left ventricular hypertrophy (HP:0001712)2.16544761
92Difficulty running (HP:0009046)2.15413279
93Meningioma (HP:0002858)2.14610880
94Abnormality of the distal phalanx of the thumb (HP:0009617)2.12448889
95Bone cyst (HP:0012062)2.12194475
96Abnormality of the sella turcica (HP:0002679)2.06499993
97Abnormal number of incisors (HP:0011064)2.01453338
98Congenital sensorineural hearing impairment (HP:0008527)2.00664232
99Partial duplication of thumb phalanx (HP:0009944)1.97420603
100Testicular atrophy (HP:0000029)1.96887878
101Bell-shaped thorax (HP:0001591)1.96114194
102Supernumerary ribs (HP:0005815)1.95900257
103Vitreoretinal degeneration (HP:0000655)1.95033693
104Aplasia/Hypoplasia of the tongue (HP:0010295)1.91025894
105Skin pits (HP:0100276)1.91014523
106Hip contracture (HP:0003273)1.90596482
107Abnormality of fatty-acid metabolism (HP:0004359)1.88915984
108Rimmed vacuoles (HP:0003805)1.88757957
109Partial duplication of the phalanx of hand (HP:0009999)1.88596999
110Dicarboxylic aciduria (HP:0003215)1.88262775
111Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88262775
112Genetic anticipation (HP:0003743)1.87818838
113Broad hallux (HP:0010055)1.87632449
114Dysmetric saccades (HP:0000641)1.86543621
115Lymphangioma (HP:0100764)1.86339268
116Rectal fistula (HP:0100590)1.86208229
117Rectovaginal fistula (HP:0000143)1.86208229
118Congenital, generalized hypertrichosis (HP:0004540)1.86133863
119Polydipsia (HP:0001959)1.85482242
120Abnormal drinking behavior (HP:0030082)1.85482242
121Protruding tongue (HP:0010808)1.84683337
122Intestinal fistula (HP:0100819)1.84082400
123Large earlobe (HP:0009748)1.83822509
124Sclerocornea (HP:0000647)1.83723808
125Gait imbalance (HP:0002141)1.82850078
126Bilateral microphthalmos (HP:0007633)1.82331502
127Abolished electroretinogram (ERG) (HP:0000550)1.81708291
128Neoplasm of the oral cavity (HP:0100649)1.80781163
129Genital tract atresia (HP:0001827)1.80488396
130Chorioretinal atrophy (HP:0000533)1.80138790
131Aplasia/Hypoplasia of the tibia (HP:0005772)1.79496357
132Broad toe (HP:0001837)1.79169982
133Decreased lacrimation (HP:0000633)1.78648661
134Congenital hepatic fibrosis (HP:0002612)1.78454240
135Cerebellar dysplasia (HP:0007033)1.77920355
136Congenital primary aphakia (HP:0007707)1.77637706
137Down-sloping shoulders (HP:0200021)1.77149649
138Inability to walk (HP:0002540)1.74768693
139EMG: neuropathic changes (HP:0003445)1.74196794
140Pulmonary artery stenosis (HP:0004415)1.73970828
141Acute necrotizing encephalopathy (HP:0006965)1.73638801
142Furrowed tongue (HP:0000221)1.73129127
143Prominent supraorbital ridges (HP:0000336)1.72932622
144Narrow palate (HP:0000189)1.72463511
145Deformed sella turcica (HP:0002681)1.72255933
146Progressive cerebellar ataxia (HP:0002073)1.71814516
147Increased CSF lactate (HP:0002490)1.71644454
148Abnormality of the incisor (HP:0000676)1.71143314
149Supernumerary bones of the axial skeleton (HP:0009144)1.70878339
150Preaxial foot polydactyly (HP:0001841)1.69595998
151Progressive inability to walk (HP:0002505)1.69274682
152Limited hip movement (HP:0008800)1.69039325
153Vaginal atresia (HP:0000148)1.68622391
154Fair hair (HP:0002286)1.68393446
155Pachygyria (HP:0001302)1.67851479
156Broad-based gait (HP:0002136)1.67551215
157Anencephaly (HP:0002323)1.67356270
158Decreased circulating renin level (HP:0003351)1.66912610
159Hypothermia (HP:0002045)1.66905241
160Hypoplastic left heart (HP:0004383)1.66831226
161Absent speech (HP:0001344)1.64769171
162Mitochondrial inheritance (HP:0001427)1.63326481
163Large for gestational age (HP:0001520)1.62329273
164Abnormal rod and cone electroretinograms (HP:0008323)1.61173305
165Febrile seizures (HP:0002373)1.61032297
166Central scotoma (HP:0000603)1.60886155
167Congenital malformation of the right heart (HP:0011723)1.60498879

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.40984593
2TTN4.75365741
3LMTK23.77314704
4PHKG13.23067824
5PHKG23.23067824
6FGFR23.18716927
7PDK33.15831349
8PDK43.15831349
9DMPK3.11986470
10MYLK3.11176473
11PIK3CA2.97408861
12PKN22.67690480
13OBSCN2.67090888
14LATS12.59893280
15BMPR1B2.28341738
16ADRBK22.23817255
17BCKDK2.14255837
18TRIB32.11214659
19CASK2.03559958
20SIK11.97249970
21WNK31.79830103
22TIE11.76025931
23GRK11.74612794
24PDK21.73860612
25GRK71.68602953
26STK241.66945795
27MARK11.63308982
28NEK11.60159518
29TNIK1.58907380
30MAP4K21.55348859
31INSRR1.53005644
32PDGFRA1.50238246
33ACVR1B1.46660137
34PINK11.42407947
35MAP3K41.42197897
36PRKD11.42010851
37PAK31.38730740
38ADRBK11.36829996
39MAP3K71.33952103
40MAPK131.32886323
41ZAK1.32486370
42CAMK41.29573647
43CAMK2D1.28589133
44EPHB21.20360557
45STK41.20180791
46AKT31.19004912
47MUSK1.18621964
48FGFR11.15855260
49WNK41.15590313
50TAOK31.13469689
51BRSK21.12464895
52DDR21.11017409
53TGFBR21.10312533
54RIPK11.06407647
55CDC42BPA1.04786331
56WNK11.01763866
57ROCK10.98856735
58CAMK1D0.96180222
59PRKAA20.95728800
60PLK20.95629536
61STK38L0.95596506
62CAMK1G0.94540645
63SIK30.93070231
64NTRK30.92863734
65PNCK0.92547872
66PIK3CG0.91627454
67MKNK20.88504357
68OXSR10.87197947
69NLK0.87124765
70TGFBR10.83780895
71PRKAA10.83032969
72MAPKAPK30.81183368
73PLK40.76700627
74EPHA30.76692629
75EPHB10.74250612
76ILK0.72583078
77ICK0.71289874
78FLT30.70921899
79TLK10.70742815
80PRKCE0.70627162
81MAPK120.69904090
82PDGFRB0.69479218
83CAMK10.68122473
84FER0.68047852
85PRKCG0.67819402
86SGK30.67309640
87STK380.65545721
88MAP3K50.64947632
89JAK10.63101320
90PRKCH0.61468936
91FGFR40.60469610
92NEK90.58455411
93MTOR0.58320862
94DAPK20.57394177
95DYRK20.56627813
96BCR0.55154697
97STK110.54773998
98ERBB30.53687267
99RET0.53034664
100CAMK2A0.51039721
101SGK20.50201618
102KSR10.50003463
103BMX0.49766189
104ROCK20.49516637
105STK30.49323688
106EPHA40.47328055
107LIMK10.46933349
108PKN10.44498242
109LATS20.43428203
110PRKACB0.42629604
111PRKD30.42101442
112TRIM280.40207416
113TRPM70.40148158
114PTK2B0.39325359
115VRK10.38805503
116PRKACG0.38665243
117PRKACA0.38626607
118RPS6KA50.36616285
119MAP2K70.35885735
120ITK0.35180659
121STK390.34131735
122KIT0.33597455
123MAPK70.33449024
124AKT20.33002928
125PRKCQ0.32783858
126RPS6KL10.32644003
127RPS6KC10.32644003
128NUAK10.32391710
129MARK30.31984664
130CAMK2B0.31906515
131PRKCA0.30712944
132IRAK10.29903500
133MARK20.29219746
134FGFR30.29193078
135MKNK10.28841855
136DAPK30.26271624
137PTK60.24916166
138SGK10.24186123
139RPS6KA60.24062732
140JAK20.23856071
141KDR0.22645317
142SGK2230.22560234
143SGK4940.22560234
144CHUK0.22540231
145PRKG10.18605198

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.99511493
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.66973036
3Dilated cardiomyopathy_Homo sapiens_hsa054143.60832610
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.43358284
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.34652750
6Cardiac muscle contraction_Homo sapiens_hsa042603.30019844
7Propanoate metabolism_Homo sapiens_hsa006403.18858868
8Fatty acid degradation_Homo sapiens_hsa000713.03349241
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.68488363
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.48879337
11Fatty acid metabolism_Homo sapiens_hsa012122.30909943
12Linoleic acid metabolism_Homo sapiens_hsa005912.16162618
13Phototransduction_Homo sapiens_hsa047442.15996841
14Basal cell carcinoma_Homo sapiens_hsa052172.07770410
15Carbon metabolism_Homo sapiens_hsa012002.04999513
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.04417278
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.98249009
18Parkinsons disease_Homo sapiens_hsa050121.95080125
19Hedgehog signaling pathway_Homo sapiens_hsa043401.84085106
20Viral myocarditis_Homo sapiens_hsa054161.81164632
21Oxidative phosphorylation_Homo sapiens_hsa001901.77193534
22Caffeine metabolism_Homo sapiens_hsa002321.71333508
23Butanoate metabolism_Homo sapiens_hsa006501.68917969
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.68490350
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.61185195
26Taste transduction_Homo sapiens_hsa047421.61153086
27Nicotine addiction_Homo sapiens_hsa050331.60059475
28Pyruvate metabolism_Homo sapiens_hsa006201.54140557
29Lysine degradation_Homo sapiens_hsa003101.51956017
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48786307
31Alzheimers disease_Homo sapiens_hsa050101.47624806
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46354820
33Morphine addiction_Homo sapiens_hsa050321.41927482
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40620904
35Olfactory transduction_Homo sapiens_hsa047401.39121084
36Fatty acid elongation_Homo sapiens_hsa000621.31022944
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.31008345
38Selenocompound metabolism_Homo sapiens_hsa004501.30781630
39Circadian rhythm_Homo sapiens_hsa047101.29811579
40Ether lipid metabolism_Homo sapiens_hsa005651.29058632
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28885937
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28545888
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.28357624
44Tryptophan metabolism_Homo sapiens_hsa003801.26523607
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26482026
46Adipocytokine signaling pathway_Homo sapiens_hsa049201.23987217
47Huntingtons disease_Homo sapiens_hsa050161.18274465
48PPAR signaling pathway_Homo sapiens_hsa033201.15867606
49GABAergic synapse_Homo sapiens_hsa047271.14004144
50Insulin resistance_Homo sapiens_hsa049311.12006504
51ECM-receptor interaction_Homo sapiens_hsa045121.06042061
52Glutamatergic synapse_Homo sapiens_hsa047241.04747831
53Serotonergic synapse_Homo sapiens_hsa047261.03313628
54cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02974277
55Salivary secretion_Homo sapiens_hsa049701.02251954
56Type II diabetes mellitus_Homo sapiens_hsa049300.98609195
57Adherens junction_Homo sapiens_hsa045200.95301779
58Focal adhesion_Homo sapiens_hsa045100.94991868
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93614721
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93252820
61Arginine biosynthesis_Homo sapiens_hsa002200.92397119
62Glucagon signaling pathway_Homo sapiens_hsa049220.91954131
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90324484
64cAMP signaling pathway_Homo sapiens_hsa040240.88731842
65Insulin signaling pathway_Homo sapiens_hsa049100.88442461
66beta-Alanine metabolism_Homo sapiens_hsa004100.88350422
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87245045
68Homologous recombination_Homo sapiens_hsa034400.87056051
69AMPK signaling pathway_Homo sapiens_hsa041520.86519567
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85798392
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84049834
72Starch and sucrose metabolism_Homo sapiens_hsa005000.83668422
73Mineral absorption_Homo sapiens_hsa049780.81324609
74Basal transcription factors_Homo sapiens_hsa030220.80353489
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80258561
76Melanoma_Homo sapiens_hsa052180.78615676
77Cocaine addiction_Homo sapiens_hsa050300.77287853
78Fanconi anemia pathway_Homo sapiens_hsa034600.77205564
79Arachidonic acid metabolism_Homo sapiens_hsa005900.75626228
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.74628963
81Regulation of autophagy_Homo sapiens_hsa041400.73688009
82Chemical carcinogenesis_Homo sapiens_hsa052040.73572869
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72760321
84Amphetamine addiction_Homo sapiens_hsa050310.72445470
85Biosynthesis of amino acids_Homo sapiens_hsa012300.72329269
86Pancreatic secretion_Homo sapiens_hsa049720.66827651
87Wnt signaling pathway_Homo sapiens_hsa043100.66763501
88Protein export_Homo sapiens_hsa030600.66726698
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65222050
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.63723475
91Renin secretion_Homo sapiens_hsa049240.63070106
92Calcium signaling pathway_Homo sapiens_hsa040200.61829092
93Phenylalanine metabolism_Homo sapiens_hsa003600.61741740
94RNA polymerase_Homo sapiens_hsa030200.60209941
95Amoebiasis_Homo sapiens_hsa051460.60163099
96Glycerolipid metabolism_Homo sapiens_hsa005610.60084629
97Pathways in cancer_Homo sapiens_hsa052000.60073010
98Proteoglycans in cancer_Homo sapiens_hsa052050.59745332
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59330990
100Dopaminergic synapse_Homo sapiens_hsa047280.59317271
101Histidine metabolism_Homo sapiens_hsa003400.55005264
102Arginine and proline metabolism_Homo sapiens_hsa003300.53863245
103Cholinergic synapse_Homo sapiens_hsa047250.53480046
104Peroxisome_Homo sapiens_hsa041460.53472083
105One carbon pool by folate_Homo sapiens_hsa006700.52009843
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49941881
107HIF-1 signaling pathway_Homo sapiens_hsa040660.49506528
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48915116
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48526992
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.48148500
111Retinol metabolism_Homo sapiens_hsa008300.46971344
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45481267
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44486118
114Small cell lung cancer_Homo sapiens_hsa052220.43853799
115Oxytocin signaling pathway_Homo sapiens_hsa049210.43568003
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43440190
117Purine metabolism_Homo sapiens_hsa002300.42891360
118Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42843876
119RNA degradation_Homo sapiens_hsa030180.42676675
120TGF-beta signaling pathway_Homo sapiens_hsa043500.39812216
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39443032
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38584586
123Ovarian steroidogenesis_Homo sapiens_hsa049130.38229252
124Long-term depression_Homo sapiens_hsa047300.37388755
125Hippo signaling pathway_Homo sapiens_hsa043900.35544945
126Metabolic pathways_Homo sapiens_hsa011000.35540980
127Fatty acid biosynthesis_Homo sapiens_hsa000610.35116754
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34078726
129Insulin secretion_Homo sapiens_hsa049110.32117091
130Dorso-ventral axis formation_Homo sapiens_hsa043200.31445691
131Renal cell carcinoma_Homo sapiens_hsa052110.29800133
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.29677321
133Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28728666
134Toxoplasmosis_Homo sapiens_hsa051450.27899188
135Rap1 signaling pathway_Homo sapiens_hsa040150.26985650
136Bile secretion_Homo sapiens_hsa049760.25832802
137Tyrosine metabolism_Homo sapiens_hsa003500.25499580
138Circadian entrainment_Homo sapiens_hsa047130.25290985
139Prostate cancer_Homo sapiens_hsa052150.25110700
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24545529
141Melanogenesis_Homo sapiens_hsa049160.24252637
142Nitrogen metabolism_Homo sapiens_hsa009100.23760523
143Endometrial cancer_Homo sapiens_hsa052130.23541767
144Axon guidance_Homo sapiens_hsa043600.23493780
145Tight junction_Homo sapiens_hsa045300.23115395
146MAPK signaling pathway_Homo sapiens_hsa040100.22465094
147Gastric acid secretion_Homo sapiens_hsa049710.20519564
148Ras signaling pathway_Homo sapiens_hsa040140.20232902
149Protein digestion and absorption_Homo sapiens_hsa049740.18552399
150Notch signaling pathway_Homo sapiens_hsa043300.17985462
151ABC transporters_Homo sapiens_hsa020100.17608260
152Galactose metabolism_Homo sapiens_hsa000520.16366978
153Fat digestion and absorption_Homo sapiens_hsa049750.15871929

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