CORO1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility (Cai et al., 2005 [PubMed 16027158]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.52349781
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.52349781
3antigen processing and presentation of endogenous antigen (GO:0019883)5.22413050
4COPI coating of Golgi vesicle (GO:0048205)4.80068581
5Golgi transport vesicle coating (GO:0048200)4.80068581
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.51434593
7positive regulation of Cdc42 GTPase activity (GO:0043089)4.04580385
8Arp2/3 complex-mediated actin nucleation (GO:0034314)3.98017463
9positive regulation of gamma-delta T cell activation (GO:0046645)3.90980550
10antigen processing and presentation via MHC class Ib (GO:0002475)3.84898154
11immunoglobulin mediated immune response (GO:0016064)3.80030430
12protein localization to endosome (GO:0036010)3.78514275
13protein retention in ER lumen (GO:0006621)3.62570432
14mannose metabolic process (GO:0006013)3.59738553
15ribosomal small subunit assembly (GO:0000028)3.49532826
16retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.46427119
17neutrophil activation involved in immune response (GO:0002283)3.43804152
18epithelial cell differentiation involved in prostate gland development (GO:0060742)3.43156800
19regulation of interferon-beta biosynthetic process (GO:0045357)3.40922195
20maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.38983000
21positive regulation of B cell differentiation (GO:0045579)3.36666516
22positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.26249819
23glycosphingolipid catabolic process (GO:0046479)3.25586119
24regulation of B cell receptor signaling pathway (GO:0050855)3.25239291
25protein maturation by protein folding (GO:0022417)3.22029706
26amyloid precursor protein catabolic process (GO:0042987)3.20951250
27negative regulation of cell size (GO:0045792)3.20449132
28GDP-mannose metabolic process (GO:0019673)3.19069463
29positive regulation of interferon-alpha production (GO:0032727)3.18537450
30B cell mediated immunity (GO:0019724)3.18105503
31negative regulation of phagocytosis (GO:0050765)3.10288312
32NIK/NF-kappaB signaling (GO:0038061)3.09857086
33response to interferon-beta (GO:0035456)3.06802825
34regulation of gamma-delta T cell differentiation (GO:0045586)3.04969287
35modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.01046705
36positive regulation by organism of defense response of other organism involved in symbiotic interact3.01046705
37modulation by symbiont of host immune response (GO:0052553)3.01046705
38positive regulation by symbiont of host defense response (GO:0052509)3.01046705
39modulation by symbiont of host defense response (GO:0052031)3.01046705
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.01046705
41response to type I interferon (GO:0034340)2.99424990
42regulation of interferon-alpha production (GO:0032647)2.98579359
43proline biosynthetic process (GO:0006561)2.97574309
44type I interferon signaling pathway (GO:0060337)2.96994076
45cellular response to type I interferon (GO:0071357)2.96994076
46regulation of B cell differentiation (GO:0045577)2.96556968
47regulation of extracellular matrix disassembly (GO:0010715)2.94032399
48glycolipid catabolic process (GO:0019377)2.92569791
49regulation of interleukin-12 biosynthetic process (GO:0045075)2.90778818
50barbed-end actin filament capping (GO:0051016)2.90033435
51regulation of defense response to virus by virus (GO:0050690)2.88790919
52semaphorin-plexin signaling pathway (GO:0071526)2.87456497
53negative regulation of erythrocyte differentiation (GO:0045647)2.86418138
54regulation of gamma-delta T cell activation (GO:0046643)2.86411352
55regulation of type I interferon-mediated signaling pathway (GO:0060338)2.86099662
56response to muramyl dipeptide (GO:0032495)2.82585121
57actin nucleation (GO:0045010)2.82324473
58positive regulation of natural killer cell differentiation (GO:0032825)2.82019739
59regulation of early endosome to late endosome transport (GO:2000641)2.80963233
60regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.80871141
61epithelial cell-cell adhesion (GO:0090136)2.78861242
62glucose catabolic process (GO:0006007)2.78616406
63basement membrane organization (GO:0071711)2.77989939
64pinocytosis (GO:0006907)2.77955395
65modulation by symbiont of host cellular process (GO:0044068)2.77193980
66amino sugar catabolic process (GO:0046348)2.76881598
67maternal placenta development (GO:0001893)2.75964840
68leukocyte aggregation (GO:0070486)2.73698223
69endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.73331655
70response to interferon-alpha (GO:0035455)2.70081547
71positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.69624467
72regulation of mammary gland epithelial cell proliferation (GO:0033599)2.69184851
73myeloid dendritic cell activation (GO:0001773)2.68847779
74viral transcription (GO:0019083)2.68666367
75glucose 6-phosphate metabolic process (GO:0051156)2.68651471
76positive regulation of antigen processing and presentation (GO:0002579)2.67521740
77apoptotic process involved in morphogenesis (GO:0060561)2.67318917
78T cell apoptotic process (GO:0070231)2.66206421
79response to peptidoglycan (GO:0032494)2.64670245
80pentose-phosphate shunt (GO:0006098)2.64289232
81modulation by virus of host process (GO:0019054)2.63328731
82regulation of response to interferon-gamma (GO:0060330)2.63008750
83positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.62712545
84peptidyl-tyrosine autophosphorylation (GO:0038083)2.62061407
85positive regulation of lamellipodium assembly (GO:0010592)2.59598421
86hepatocyte apoptotic process (GO:0097284)2.59228971
87cellular response to interferon-beta (GO:0035458)2.58640910
88regulation of superoxide anion generation (GO:0032928)2.58539624
89cell-cell junction maintenance (GO:0045217)2.57584201
90activation of Rac GTPase activity (GO:0032863)2.57293768
91myeloid dendritic cell differentiation (GO:0043011)2.56204253
92translational termination (GO:0006415)2.55162668
93respiratory burst (GO:0045730)2.54783796
94mature B cell differentiation involved in immune response (GO:0002313)2.53818717
95branching involved in mammary gland duct morphogenesis (GO:0060444)2.53526297
96regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.53442896
97interferon-gamma-mediated signaling pathway (GO:0060333)2.53418925
98negative regulation of viral release from host cell (GO:1902187)2.53372892
99macrophage activation involved in immune response (GO:0002281)2.51367526
100natural killer cell differentiation (GO:0001779)2.48859253
101positive regulation of keratinocyte differentiation (GO:0045618)2.46996372
102B cell receptor signaling pathway (GO:0050853)2.46601445
103negative regulation of interleukin-12 production (GO:0032695)2.46478268
104defense response to protozoan (GO:0042832)2.46231603
105endothelial tube morphogenesis (GO:0061154)2.45534734
106morphogenesis of an endothelium (GO:0003159)2.45534734
107regulation of necroptotic process (GO:0060544)2.45310343
108negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.45190444
109modulation by virus of host morphology or physiology (GO:0019048)2.44004970
110adhesion of symbiont to host (GO:0044406)2.43985688
111response to protozoan (GO:0001562)2.43674926
112cellular response to zinc ion (GO:0071294)2.43081413
113stress fiber assembly (GO:0043149)2.42635254
114cellular response to virus (GO:0098586)2.42334350
115neutrophil activation (GO:0042119)2.42032212
116regulation of cholesterol homeostasis (GO:2000188)2.41874252
117negative regulation of granulocyte differentiation (GO:0030853)2.41823046
118membrane protein ectodomain proteolysis (GO:0006509)2.41541802
119JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.40597351
120hyaluronan catabolic process (GO:0030214)2.40488386
121adherens junction assembly (GO:0034333)2.40271097
122dendritic cell differentiation (GO:0097028)2.40219745
123regulation of leukocyte degranulation (GO:0043300)2.39840416
124oligosaccharide catabolic process (GO:0009313)2.39321120
125NADPH regeneration (GO:0006740)2.38545329
126lymphocyte apoptotic process (GO:0070227)2.37724438
127regulation of antigen processing and presentation (GO:0002577)2.37251042
128ceramide catabolic process (GO:0046514)2.37017263
129positive regulation of interferon-beta production (GO:0032728)2.36989965
130desmosome organization (GO:0002934)2.35207048
131lipopolysaccharide-mediated signaling pathway (GO:0031663)2.34720420
132platelet aggregation (GO:0070527)2.33580420
133cytoskeletal anchoring at plasma membrane (GO:0007016)2.33504160
134myeloid cell activation involved in immune response (GO:0002275)2.32703274
135translational elongation (GO:0006414)2.32481937
136focal adhesion assembly (GO:0048041)2.32143744
137cell-substrate adherens junction assembly (GO:0007045)2.32143744
138regulation of cholesterol biosynthetic process (GO:0045540)2.32027727
139apoptotic cell clearance (GO:0043277)2.30859873
140angiogenesis involved in wound healing (GO:0060055)2.30477095
141regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.30087931
142leukocyte cell-cell adhesion (GO:0007159)2.29779653
143granulocyte activation (GO:0036230)2.28940307
144regulation of water loss via skin (GO:0033561)2.28499153
145embryonic process involved in female pregnancy (GO:0060136)2.28192791
146adhesion of symbiont to host cell (GO:0044650)2.27811252
147virion attachment to host cell (GO:0019062)2.27811252
148regulation of viral release from host cell (GO:1902186)2.27803840
149peptide catabolic process (GO:0043171)2.27464215
150positive regulation of macrophage differentiation (GO:0045651)2.25792942
151amyloid precursor protein metabolic process (GO:0042982)2.25508699
152negative regulation of fatty acid transport (GO:2000192)2.25496115
153negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.24805059
154interferon-gamma secretion (GO:0072643)2.23683952
155cellular extravasation (GO:0045123)2.23652991
156low-density lipoprotein particle clearance (GO:0034383)2.23651885
157SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.23533501
158regulation of protein heterodimerization activity (GO:0043497)2.22944506
159regulation of glucose import in response to insulin stimulus (GO:2001273)2.22671298
160activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.22399804
161endosome to pigment granule transport (GO:0043485)2.22182427
162endosome to melanosome transport (GO:0035646)2.22182427
163regulation of natural killer cell differentiation (GO:0032823)2.21964727
164sequestering of actin monomers (GO:0042989)2.21889354
165UV protection (GO:0009650)2.21656049
166regulation of cholesterol storage (GO:0010885)2.21506599
167positive regulation of receptor recycling (GO:0001921)2.20925762
168regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.20626306
169regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.20288082
170negative regulation of stress fiber assembly (GO:0051497)2.19501650
171virion assembly (GO:0019068)2.18935985
172dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.18429047
173embryo implantation (GO:0007566)2.18224132
174sphingolipid catabolic process (GO:0030149)2.17812658
175response to laminar fluid shear stress (GO:0034616)2.16191852
176membrane lipid catabolic process (GO:0046466)2.15517226
177NADH metabolic process (GO:0006734)2.15337479

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.82884240
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.16158311
3E2F7_22180533_ChIP-Seq_HELA_Human3.04920525
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.75802862
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.67028134
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.59829600
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.59490490
8MYC_22102868_ChIP-Seq_BL_Human2.42769019
9VDR_21846776_ChIP-Seq_THP-1_Human2.38490842
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.37675988
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.29216633
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.26235910
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.23276938
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.13732281
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.13445391
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.11779959
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.11767048
18ZNF263_19887448_ChIP-Seq_K562_Human2.09428718
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.08833158
20* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08460814
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.07783921
22* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05376912
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.03438317
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.02001330
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.98148436
26* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96658425
27SPI1_23547873_ChIP-Seq_NB4_Human1.92455068
28SCL_19346495_ChIP-Seq_HPC-7_Human1.92445983
29* MAF_26560356_Chip-Seq_TH1_Human1.88399509
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.84279376
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.82230562
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78297178
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.77076093
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.74198916
35VDR_24763502_ChIP-Seq_THP-1_Human1.74064196
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.73843200
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.73660415
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.67650021
39MYB_26560356_Chip-Seq_TH2_Human1.66701964
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.65404173
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61339799
42UTX_26944678_Chip-Seq_JUKART_Human1.59912276
43* TET1_21451524_ChIP-Seq_MESCs_Mouse1.56532062
44DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.56162542
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54029786
46P68_20966046_ChIP-Seq_HELA_Human1.51484979
47MYB_26560356_Chip-Seq_TH1_Human1.50368153
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50053579
49TCF7_22412390_ChIP-Seq_EML_Mouse1.49778115
50SRY_22984422_ChIP-ChIP_TESTIS_Rat1.49468770
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47712792
52RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47064227
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46521949
54* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46311474
55KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.45584177
56MYC_18555785_ChIP-Seq_MESCs_Mouse1.44140142
57CTCF_27219007_Chip-Seq_ERYTHROID_Human1.43275987
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.41879369
59STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39930379
60SA1_27219007_Chip-Seq_ERYTHROID_Human1.36376827
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.33401228
62FOXM1_23109430_ChIP-Seq_U2OS_Human1.32667211
63KDM2B_26808549_Chip-Seq_K562_Human1.32191533
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32170777
65UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31491803
66MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31454426
67ESR1_21235772_ChIP-Seq_MCF-7_Human1.29039953
68SMC4_20622854_ChIP-Seq_HELA_Human1.28618082
69RUNX1_27514584_Chip-Seq_MCF-7_Human1.27800397
70BCOR_27268052_Chip-Seq_Bcells_Human1.27449806
71SPI1_23127762_ChIP-Seq_K562_Human1.27056629
72* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25545647
73ATF3_27146783_Chip-Seq_COLON_Human1.25297780
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24607158
75MAF_26560356_Chip-Seq_TH2_Human1.24016366
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.23753161
77TFEB_21752829_ChIP-Seq_HELA_Human1.23001719
78ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21641599
79GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21222451
80EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21057632
81* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20472867
82RUNX_20019798_ChIP-Seq_JUKART_Human1.19683598
83LXR_22292898_ChIP-Seq_THP-1_Human1.19232111
84* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18241978
85TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18199520
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17802111
87FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.17665917
88CREB1_26743006_Chip-Seq_LNCaP_Human1.17407364
89P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17382616
90ELF1_20517297_ChIP-Seq_JURKAT_Human1.16486959
91LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15388559
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15185367
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14634358
94STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13536077
95CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13304986
96* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11495341
97KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11372553
98STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10873756
99RXR_22158963_ChIP-Seq_LIVER_Mouse1.10847886
100CLOCK_20551151_ChIP-Seq_293T_Human1.10715794
101* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09848245
102* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09345620
103* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09087881
104KDM2B_26808549_Chip-Seq_DND41_Human1.08542386
105KDM2B_26808549_Chip-Seq_JURKAT_Human1.07944649
106XRN2_22483619_ChIP-Seq_HELA_Human1.07338165
107MYC_18358816_ChIP-ChIP_MESCs_Mouse1.06722743
108FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.06434277
109TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06220459
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06180274
111TP53_22127205_ChIP-Seq_IMR90_Human1.06061938
112RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05324195
113HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05322629
114CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05040983
115TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04789577
116* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04676278
117KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04507321
118TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04276947
119KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03795110
120CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03541877
121GATA1_19941827_ChIP-Seq_MEL_Mouse1.03438315
122PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03293266
123BCL6_27268052_Chip-Seq_Bcells_Human1.02480203
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02440989
125TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02200293
126CTCF_26484167_Chip-Seq_Bcells_Mouse1.01579393
127SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01286069
128GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01253571
129KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01207800
130P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00854631
131* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00703124
132MYC_19079543_ChIP-ChIP_MESCs_Mouse1.00022790
133ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.98851808
134CIITA_25753668_ChIP-Seq_RAJI_Human0.98592187
135* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.96885710
136HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96541777
137LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95660609
138NCOR1_26117541_ChIP-Seq_K562_Human0.95241661
139KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94877224
140* RACK7_27058665_Chip-Seq_MCF-7_Human0.94385128
141PU_27001747_Chip-Seq_BMDM_Mouse0.94325460
142PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94117425
143NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.92972583
144PPARA_22158963_ChIP-Seq_LIVER_Mouse0.92504316
145Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.92423276
146SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91691660

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.52504369
2MP0005451_abnormal_body_composition3.19032648
3MP0000685_abnormal_immune_system2.82898012
4MP0003436_decreased_susceptibility_to2.69168179
5MP0009785_altered_susceptibility_to2.62176953
6MP0008260_abnormal_autophagy2.31249279
7MP0005671_abnormal_response_to2.30242267
8MP0005025_abnormal_response_to2.23251303
9MP0002452_abnormal_antigen_presenting2.18696927
10MP0001800_abnormal_humoral_immune2.18463781
11MP0005000_abnormal_immune_tolerance2.18000370
12MP0004858_abnormal_nervous_system2.17699762
13MP0005387_immune_system_phenotype2.15761456
14MP0001790_abnormal_immune_system2.15761456
15MP0002796_impaired_skin_barrier2.12202062
16MP0002419_abnormal_innate_immunity2.11455289
17MP0005058_abnormal_lysosome_morphology2.06875178
18MP0008438_abnormal_cutaneous_collagen2.05574928
19MP0005464_abnormal_platelet_physiology2.05515614
20MP0002148_abnormal_hypersensitivity_rea2.03150114
21MP0002396_abnormal_hematopoietic_system2.03011730
22MP0002166_altered_tumor_susceptibility2.00913405
23MP0004264_abnormal_extraembryonic_tissu1.96578802
24MP0002420_abnormal_adaptive_immunity1.95657627
25MP0001819_abnormal_immune_cell1.95654905
26MP0002723_abnormal_immune_serum1.95269608
27MP0010352_gastrointestinal_tract_polyps1.91475254
28MP0006054_spinal_hemorrhage1.88108102
29MP0004185_abnormal_adipocyte_glucose1.85944919
30MP0003191_abnormal_cellular_cholesterol1.84238654
31MP0009333_abnormal_splenocyte_physiolog1.84108885
32MP0003303_peritoneal_inflammation1.83618552
33MP0003724_increased_susceptibility_to1.81726795
34MP0010155_abnormal_intestine_physiology1.81552316
35MP0003705_abnormal_hypodermis_morpholog1.80691845
36MP0009840_abnormal_foam_cell1.80168827
37MP0006082_CNS_inflammation1.79316451
38MP0005397_hematopoietic_system_phenotyp1.78473825
39MP0001545_abnormal_hematopoietic_system1.78473825
40MP0003300_gastrointestinal_ulcer1.78193706
41MP0004947_skin_inflammation1.76140454
42MP0002398_abnormal_bone_marrow1.74776845
43MP0003763_abnormal_thymus_physiology1.72103723
44MP0002405_respiratory_system_inflammati1.66630667
45MP0002006_tumorigenesis1.63493856
46MP0001873_stomach_inflammation1.62418296
47MP0000716_abnormal_immune_system1.62307661
48MP0001533_abnormal_skeleton_physiology1.59980983
49MP0009278_abnormal_bone_marrow1.58415472
50MP0003566_abnormal_cell_adhesion1.57740554
51MP0000858_altered_metastatic_potential1.57398828
52MP0000689_abnormal_spleen_morphology1.54231923
53MP0004510_myositis1.54164366
54MP0004808_abnormal_hematopoietic_stem1.52986956
55MP0001845_abnormal_inflammatory_respons1.51660185
56MP0002722_abnormal_immune_system1.51174639
57MP0005501_abnormal_skin_physiology1.50414008
58MP0000490_abnormal_crypts_of1.50038305
59MP0003172_abnormal_lysosome_physiology1.47998387
60MP0002429_abnormal_blood_cell1.45710589
61MP0001853_heart_inflammation1.45132160
62MP0000465_gastrointestinal_hemorrhage1.44532523
63MP0005257_abnormal_intraocular_pressure1.43035094
64MP0005023_abnormal_wound_healing1.42453575
65MP0000343_altered_response_to1.39504422
66MP0005409_darkened_coat_color1.30838656
67MP0003448_altered_tumor_morphology1.27045939
68MP0002933_joint_inflammation1.24913317
69MP0003866_abnormal_defecation1.24589690
70MP0008469_abnormal_protein_level1.23598748
71MP0010307_abnormal_tumor_latency1.23261465
72MP0000604_amyloidosis1.23260590
73MP0003329_amyloid_beta_deposits1.22983085
74MP0003183_abnormal_peptide_metabolism1.20147414
75MP0002877_abnormal_melanocyte_morpholog1.19756809
76MP0000678_abnormal_parathyroid_gland1.18164556
77MP0010234_abnormal_vibrissa_follicle1.17581271
78MP0002254_reproductive_system_inflammat1.16971738
79MP0000537_abnormal_urethra_morphology1.13524943
80MP0001958_emphysema1.11985590
81MP0005666_abnormal_adipose_tissue1.10014339
82MP0003279_aneurysm1.09863995
83MP0001216_abnormal_epidermal_layer1.05717854
84MP0000703_abnormal_thymus_morphology1.03273343
85MP0004782_abnormal_surfactant_physiolog1.02873414
86MP0005360_urolithiasis1.00654056
87MP0002098_abnormal_vibrissa_morphology1.00047866
88MP0002139_abnormal_hepatobiliary_system0.98248644
89MP0004233_abnormal_muscle_weight0.98233698
90MP0002998_abnormal_bone_remodeling0.97475183
91MP0005310_abnormal_salivary_gland0.95956595
92MP0002019_abnormal_tumor_incidence0.95921592
93MP0008007_abnormal_cellular_replicative0.94769081
94MP0003453_abnormal_keratinocyte_physiol0.93198327
95MP0005083_abnormal_biliary_tract0.92800146
96MP0009764_decreased_sensitivity_to0.91883061
97MP0005076_abnormal_cell_differentiation0.90732195
98MP0005174_abnormal_tail_pigmentation0.90442291
99MP0003806_abnormal_nucleotide_metabolis0.89861742
100MP0005275_abnormal_skin_tensile0.89573622
101MP0003186_abnormal_redox_activity0.89455956
102MP0004381_abnormal_hair_follicle0.89290855
103MP0001881_abnormal_mammary_gland0.88283845
104MP0005390_skeleton_phenotype0.87148452
105MP0000767_abnormal_smooth_muscle0.86988608
106MP0002896_abnormal_bone_mineralization0.86349078
107MP0000249_abnormal_blood_vessel0.84516983
108MP0004272_abnormal_basement_membrane0.84315377
109MP0005375_adipose_tissue_phenotype0.82685775
110MP0003693_abnormal_embryo_hatching0.82685257
111MP0009931_abnormal_skin_appearance0.82183424
112MP0002089_abnormal_postnatal_growth/wei0.81780583
113MP0002060_abnormal_skin_morphology0.79584474
114MP0000477_abnormal_intestine_morphology0.79580456
115MP0005165_increased_susceptibility_to0.79191495
116MP0003091_abnormal_cell_migration0.77704060
117MP0009384_cardiac_valve_regurgitation0.76371553
118MP0001915_intracranial_hemorrhage0.75849199
119MP0001243_abnormal_dermal_layer0.75791403
120MP0003075_altered_response_to0.75785118
121MP0003077_abnormal_cell_cycle0.74960873
122MP0000598_abnormal_liver_morphology0.74923459
123MP0009763_increased_sensitivity_to0.74176133
124MP0005381_digestive/alimentary_phenotyp0.72190405
125MP0003828_pulmonary_edema0.70391470
126MP0003795_abnormal_bone_structure0.69228015
127MP0002136_abnormal_kidney_physiology0.67789267
128MP0004957_abnormal_blastocyst_morpholog0.67738266
129MP0005670_abnormal_white_adipose0.67452574
130MP0001663_abnormal_digestive_system0.66377317
131MP0001851_eye_inflammation0.65381300
132MP0001849_ear_inflammation0.64372926
133MP0002132_abnormal_respiratory_system0.64045852
134MP0005166_decreased_susceptibility_to0.63306709
135MP0000609_abnormal_liver_physiology0.63236896

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.34867222
2Recurrent abscess formation (HP:0002722)4.12571250
3Eczematoid dermatitis (HP:0000976)4.12130613
4Recurrent bacterial skin infections (HP:0005406)3.67611857
5Myositis (HP:0100614)3.64951494
6Thrombocytosis (HP:0001894)3.62512229
7Chronic otitis media (HP:0000389)3.45811267
8Vacuolated lymphocytes (HP:0001922)3.38124225
9Autoimmune thrombocytopenia (HP:0001973)3.35292508
10Thin bony cortex (HP:0002753)3.32643618
11Abnormality of macrophages (HP:0004311)3.31797723
12Petechiae (HP:0000967)3.31060915
13Flat acetabular roof (HP:0003180)3.15852998
14Recurrent viral infections (HP:0004429)3.11333502
15Axonal loss (HP:0003447)3.10696568
16Recurrent fungal infections (HP:0002841)3.10676803
17Cellulitis (HP:0100658)3.07385607
18IgM deficiency (HP:0002850)3.05106217
19Increased cerebral lipofuscin (HP:0011813)3.03038351
20Interstitial pulmonary disease (HP:0006530)3.02176604
21Recurrent bronchitis (HP:0002837)2.99418888
22Abnormality of the distal phalanges of the toes (HP:0010182)2.91643157
23Increased neuronal autofluorescent lipopigment (HP:0002074)2.78498538
24Recurrent gram-negative bacterial infections (HP:0005420)2.77081438
25Distal lower limb muscle weakness (HP:0009053)2.76655465
26Abnormality of the nasal mucosa (HP:0000433)2.76261362
27Protrusio acetabuli (HP:0003179)2.74862151
28Broad face (HP:0000283)2.71739254
29Pustule (HP:0200039)2.71316146
30J-shaped sella turcica (HP:0002680)2.71250590
31Vertebral compression fractures (HP:0002953)2.68804672
32Orchitis (HP:0100796)2.67400654
33Hyperacusis (HP:0010780)2.67169848
34Recurrent skin infections (HP:0001581)2.65665643
35Nasal polyposis (HP:0100582)2.62485207
36Spontaneous hematomas (HP:0007420)2.61647188
37Achilles tendon contracture (HP:0001771)2.56865420
38Gastrointestinal inflammation (HP:0004386)2.51405382
39Cervical subluxation (HP:0003308)2.49244939
40Abnormality of T cell physiology (HP:0011840)2.48701499
41Hemorrhage of the eye (HP:0011885)2.47914752
42Dysostosis multiplex (HP:0000943)2.46850662
43Hematochezia (HP:0002573)2.43446695
44Peritonitis (HP:0002586)2.40721225
45Inflammation of the large intestine (HP:0002037)2.37951452
46Colitis (HP:0002583)2.36744723
47Abnormality of the Achilles tendon (HP:0005109)2.34376721
48Distal lower limb amyotrophy (HP:0008944)2.33397392
49Vasculitis (HP:0002633)2.32400259
50Abnormality of T cells (HP:0002843)2.29032651
51Mediastinal lymphadenopathy (HP:0100721)2.28676156
52Systemic lupus erythematosus (HP:0002725)2.28259946
53Short nail (HP:0001799)2.28047852
54Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.26789145
55Upper limb amyotrophy (HP:0009129)2.26396879
56Distal upper limb amyotrophy (HP:0007149)2.26396879
57Loss of speech (HP:0002371)2.25259774
58Periodontitis (HP:0000704)2.24222535
59Purpura (HP:0000979)2.24060205
60Prolonged bleeding time (HP:0003010)2.23961511
61Urinary glycosaminoglycan excretion (HP:0003541)2.21516901
62Mucopolysacchariduria (HP:0008155)2.21516901
63Chronic mucocutaneous candidiasis (HP:0002728)2.20918900
64Recurrent cutaneous fungal infections (HP:0011370)2.20918900
65Increased IgE level (HP:0003212)2.20036743
66Bone pain (HP:0002653)2.18975109
67Osteolytic defects of the hand bones (HP:0009699)2.18860500
68Osteolytic defects of the phalanges of the hand (HP:0009771)2.18860500
69Epistaxis (HP:0000421)2.17591004
70Abnormal delayed hypersensitivity skin test (HP:0002963)2.16519013
71Leukocytosis (HP:0001974)2.15554444
72Meningitis (HP:0001287)2.14631711
73Impaired platelet aggregation (HP:0003540)2.14509307
74Abnormal platelet function (HP:0011869)2.14509307
75Gastrointestinal stroma tumor (HP:0100723)2.14034147
76Arterial thrombosis (HP:0004420)2.12674704
77Abnormal platelet volume (HP:0011876)2.12248733
78Abnormality of cells of the lymphoid lineage (HP:0012140)2.11553121
79Emphysema (HP:0002097)2.11393659
80Hypergammaglobulinemia (HP:0010702)2.10333796
81Osteomyelitis (HP:0002754)2.10027827
82Lymphopenia (HP:0001888)2.09527821
83Gingival bleeding (HP:0000225)2.08894556
84Hyperparathyroidism (HP:0000843)2.08791586
85Malnutrition (HP:0004395)2.08665611
86Nuclear cataract (HP:0100018)2.08257811
87Urticaria (HP:0001025)2.06754420
88Panhypogammaglobulinemia (HP:0003139)2.05865339
89Cerebral aneurysm (HP:0004944)2.04019079
90Aortic aneurysm (HP:0004942)2.03081239
91Increased connective tissue (HP:0009025)2.03068161
92Flattened epiphyses (HP:0003071)2.02914311
93Abnormality of mucopolysaccharide metabolism (HP:0011020)2.01636494
94Abnormality of polysaccharide metabolism (HP:0011012)2.01636494
95Abnormality of glycosaminoglycan metabolism (HP:0004371)2.01636494
96Aplastic anemia (HP:0001915)2.00668387
97Agammaglobulinemia (HP:0004432)2.00151023
98Progressive neurologic deterioration (HP:0002344)1.99588228
99Nonimmune hydrops fetalis (HP:0001790)1.99080023
100Blue sclerae (HP:0000592)1.98713931
101Ankle contracture (HP:0006466)1.98095625
102Myocardial infarction (HP:0001658)1.95122824
103Joint stiffness (HP:0001387)1.93200972
104Prolonged neonatal jaundice (HP:0006579)1.92904105
105Skin ulcer (HP:0200042)1.90602066
106Cerebral inclusion bodies (HP:0100314)1.90343918
107Abdominal distention (HP:0003270)1.89667253
108Optic neuritis (HP:0100653)1.89470662
109Retrobulbar optic neuritis (HP:0100654)1.89470662
110Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.87767049
111Amyloidosis (HP:0011034)1.87541163
112Recurrent lower respiratory tract infections (HP:0002783)1.87484916
113Increased mean platelet volume (HP:0011877)1.87412160
114Abnormality of the thoracic spine (HP:0100711)1.86505132
115Hepatosplenomegaly (HP:0001433)1.86028809
116Abnormality of T cell number (HP:0011839)1.85737074
117Gingivitis (HP:0000230)1.85613106
118Abnormality of glycolipid metabolism (HP:0010969)1.85423072
119Abnormality of liposaccharide metabolism (HP:0010968)1.85423072
120Abnormality of glycosphingolipid metabolism (HP:0004343)1.85423072
121Granulocytopenia (HP:0001913)1.83013091
122Pathologic fracture (HP:0002756)1.82999419
123Premature rupture of membranes (HP:0001788)1.82540927
124T lymphocytopenia (HP:0005403)1.82066959
125Abnormality of the distal phalanx of the thumb (HP:0009617)1.81859131
126Stridor (HP:0010307)1.81523139
127Congenital glaucoma (HP:0001087)1.80328431
128Beaking of vertebral bodies (HP:0004568)1.80033839
129Reticulocytopenia (HP:0001896)1.79934476
130Increased serum ferritin (HP:0003281)1.79453258
131Thoracic kyphosis (HP:0002942)1.79418149
132Obstructive lung disease (HP:0006536)1.79117033
133Chronic obstructive pulmonary disease (HP:0006510)1.79117033
134Polygenic inheritance (HP:0010982)1.77770510
135Aortic dissection (HP:0002647)1.75703114
136Growth hormone excess (HP:0000845)1.75372372
137Centrally nucleated skeletal muscle fibers (HP:0003687)1.75210650
138Fatigue (HP:0012378)1.74983394
139Ulnar bowing (HP:0003031)1.74562930
140Biconcave vertebral bodies (HP:0004586)1.74211755
141Eosinophilia (HP:0001880)1.74101612
142Bulbar palsy (HP:0001283)1.73924162
143Verrucae (HP:0200043)1.73707375
144Hand muscle atrophy (HP:0009130)1.73463364
145Segmental peripheral demyelination/remyelination (HP:0003481)1.72822990
146Neuronal loss in central nervous system (HP:0002529)1.71566776
147Abnormality of carpal bone ossification (HP:0006257)1.71308025
148Cardiomegaly (HP:0001640)1.71265500
149Multiple lipomas (HP:0001012)1.71091225
150Neurofibrillary tangles (HP:0002185)1.68753901
151Upper motor neuron abnormality (HP:0002127)1.68423756
152Esophageal varix (HP:0002040)1.68173185
153Hypertensive crisis (HP:0100735)1.67146772
154Hypertriglyceridemia (HP:0002155)1.66656018
155Asymmetric septal hypertrophy (HP:0001670)1.65884702
156Elevated alkaline phosphatase (HP:0003155)1.65452576
157Abnormal ossification of hand bones (HP:0005921)1.65215068
158Testicular atrophy (HP:0000029)1.64734085
159Deformed sella turcica (HP:0002681)1.63776302
160Sparse lateral eyebrow (HP:0005338)1.63338152
161Spinal cord compression (HP:0002176)1.62241089
162Long palpebral fissure (HP:0000637)1.60790525
163Severe short stature (HP:0003510)1.60498419
164Abnormality of alkaline phosphatase activity (HP:0004379)1.56519122

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.62754928
2TRIB33.00449117
3SMG12.96658867
4ERN12.95800794
5PKN22.56332595
6TYK22.55747565
7EEF2K2.48099393
8TBK12.43582842
9KIT2.37275177
10BLK2.36976109
11PRPF4B2.07386794
12JAK32.05264966
13ZAP702.01021620
14FLT31.96753048
15STK101.91495435
16NME21.91066277
17LRRK21.90847751
18ICK1.83069436
19KDR1.81371158
20MAP2K31.76103085
21TGFBR21.74689941
22CAMK1D1.73385772
23BTK1.73111183
24MAP3K101.70614590
25PIM21.68313989
26IKBKE1.61137280
27RPS6KA41.59270830
28PAK41.59155050
29CSF1R1.58281341
30ARAF1.53204550
31PRKD21.52177343
32MAP3K141.48837203
33TGFBR11.38510070
34TESK21.31800412
35IKBKB1.30960694
36TAOK21.30638277
37JAK11.29084864
38PTK61.28799925
39TXK1.25033126
40FGFR41.24291126
41IRAK41.18803192
42SYK1.17387597
43RIPK11.16438803
44MATK1.15739734
45SCYL21.14344030
46GRK61.14272001
47EPHB11.14013293
48BUB11.04845407
49RPS6KB21.02433666
50PIM11.02013938
51TEC0.99698586
52NEK20.99271878
53MAP3K110.99128946
54CDK120.98004183
55TESK10.97901603
56MARK20.97405473
57CSK0.95802099
58CDC42BPA0.95598690
59MAPKAPK30.95063781
60NEK90.94626178
61MAP3K10.94624333
62LIMK10.94329517
63ITK0.91620313
64LCK0.90992983
65CAMK1G0.90704742
66RPS6KA20.89802406
67HCK0.89352277
68TTN0.89323675
69CHUK0.89036999
70BCKDK0.88142562
71PDPK10.85950532
72LMTK20.83095043
73IRAK30.81390165
74MAP3K80.80359752
75TNK20.79118134
76LYN0.78296135
77IRAK20.77685855
78MTOR0.75598512
79ILK0.75312018
80CDK60.72849929
81PRKG20.72727840
82PASK0.71747711
83MAP3K30.71273709
84TRPM70.70989201
85MAP2K20.69248278
86RIPK40.69113119
87SIK10.68975734
88MST40.68134704
89PRKCI0.67744220
90CLK10.67634792
91DDR20.67598582
92WEE10.65729793
93JAK20.64677125
94EPHB20.63028336
95SIK30.62351684
96FGFR30.61382946
97CDK40.58548679
98MAPKAPK20.57760899
99MAPK110.56820801
100STK40.56670325
101NLK0.56484600
102MARK30.56350136
103TAOK10.53999984
104BRAF0.53751055
105BMX0.52919098
106ABL20.52458080
107TAOK30.50468562
108HIPK20.49934049
109MYLK0.49929881
110KSR20.45564679
111MAP3K130.44470436
112CDK70.44284743
113RPS6KA60.43746442
114PAK20.42712511
115PRKD10.41807081
116PTK20.41181952
117RET0.40088994
118DAPK30.39660838
119PDK10.38280062
120FER0.38227499
121PAK10.37945470
122CAMKK10.37521681
123MET0.36324862
124FGR0.35995069
125EPHA20.35613017
126DYRK1B0.34291994
127TIE10.34184618
128BRSK20.34086656
129MOS0.33733146
130PRKD30.33130232
131MAP2K60.32518503
132RPS6KC10.32306224
133RPS6KL10.32306224
134MST1R0.32013295
135PDGFRA0.31953376
136ACVR1B0.30379703
137VRK20.28154200

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.60780220
2Primary immunodeficiency_Homo sapiens_hsa053402.34996231
3Antigen processing and presentation_Homo sapiens_hsa046122.10354296
4Other glycan degradation_Homo sapiens_hsa005112.02289855
5Fructose and mannose metabolism_Homo sapiens_hsa000511.98769858
6DNA replication_Homo sapiens_hsa030301.94238709
7NF-kappa B signaling pathway_Homo sapiens_hsa040641.91286318
8Legionellosis_Homo sapiens_hsa051341.90097448
9Osteoclast differentiation_Homo sapiens_hsa043801.88036377
10Measles_Homo sapiens_hsa051621.85336298
11B cell receptor signaling pathway_Homo sapiens_hsa046621.81739102
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.77731655
13Shigellosis_Homo sapiens_hsa051311.77701887
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77632393
15Cyanoamino acid metabolism_Homo sapiens_hsa004601.73570114
16Ribosome_Homo sapiens_hsa030101.71496899
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.71104695
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.67106675
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.64854355
20Lysosome_Homo sapiens_hsa041421.61160335
21Staphylococcus aureus infection_Homo sapiens_hsa051501.58975063
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.56963464
23Toxoplasmosis_Homo sapiens_hsa051451.54831368
24Hematopoietic cell lineage_Homo sapiens_hsa046401.54151109
25Malaria_Homo sapiens_hsa051441.53153811
26Pertussis_Homo sapiens_hsa051331.52433154
27Apoptosis_Homo sapiens_hsa042101.48110771
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.47612703
29Herpes simplex infection_Homo sapiens_hsa051681.46913194
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.45603950
31Base excision repair_Homo sapiens_hsa034101.41135577
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.38685563
33Influenza A_Homo sapiens_hsa051641.37187805
34Tuberculosis_Homo sapiens_hsa051521.35903938
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.33563070
36Caffeine metabolism_Homo sapiens_hsa002321.33006137
37Vibrio cholerae infection_Homo sapiens_hsa051101.32935628
38Mismatch repair_Homo sapiens_hsa034301.27008752
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25352778
40Salmonella infection_Homo sapiens_hsa051321.24676390
41Acute myeloid leukemia_Homo sapiens_hsa052211.24543090
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.23724569
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21615759
44Prion diseases_Homo sapiens_hsa050201.21290742
45Fatty acid biosynthesis_Homo sapiens_hsa000611.20042256
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.18792422
47TNF signaling pathway_Homo sapiens_hsa046681.18607481
48Chronic myeloid leukemia_Homo sapiens_hsa052201.15085873
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13472942
50Hepatitis B_Homo sapiens_hsa051611.12190930
51Viral myocarditis_Homo sapiens_hsa054161.10867978
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07076640
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04584843
54Endocytosis_Homo sapiens_hsa041441.04358349
55Small cell lung cancer_Homo sapiens_hsa052220.99583685
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99527094
57Platelet activation_Homo sapiens_hsa046110.99375883
58p53 signaling pathway_Homo sapiens_hsa041150.99268932
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98829611
60Proteasome_Homo sapiens_hsa030500.97509957
61Endometrial cancer_Homo sapiens_hsa052130.97350682
62Allograft rejection_Homo sapiens_hsa053300.96613576
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93434492
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93066167
65Viral carcinogenesis_Homo sapiens_hsa052030.92129918
66Pentose phosphate pathway_Homo sapiens_hsa000300.91858819
67Sphingolipid metabolism_Homo sapiens_hsa006000.91197950
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88897320
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87997955
70Graft-versus-host disease_Homo sapiens_hsa053320.85983865
71Epstein-Barr virus infection_Homo sapiens_hsa051690.84507363
72T cell receptor signaling pathway_Homo sapiens_hsa046600.82559656
73Pancreatic cancer_Homo sapiens_hsa052120.82538231
74Insulin resistance_Homo sapiens_hsa049310.79963342
75Insulin signaling pathway_Homo sapiens_hsa049100.79402313
76Hepatitis C_Homo sapiens_hsa051600.79319663
77Renal cell carcinoma_Homo sapiens_hsa052110.78904393
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78578088
79HTLV-I infection_Homo sapiens_hsa051660.77408597
80Chemokine signaling pathway_Homo sapiens_hsa040620.76673517
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75568375
82Notch signaling pathway_Homo sapiens_hsa043300.73904258
83Galactose metabolism_Homo sapiens_hsa000520.73568952
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.72927863
85One carbon pool by folate_Homo sapiens_hsa006700.70782101
86Biosynthesis of amino acids_Homo sapiens_hsa012300.70768335
87Prostate cancer_Homo sapiens_hsa052150.68378752
88Prolactin signaling pathway_Homo sapiens_hsa049170.68281552
89Thyroid cancer_Homo sapiens_hsa052160.68202478
90Asthma_Homo sapiens_hsa053100.68134874
91Amoebiasis_Homo sapiens_hsa051460.64859916
92Sulfur metabolism_Homo sapiens_hsa009200.64739340
93Sulfur relay system_Homo sapiens_hsa041220.64458270
94Phagosome_Homo sapiens_hsa041450.62394139
95Bladder cancer_Homo sapiens_hsa052190.61402879
96Glutathione metabolism_Homo sapiens_hsa004800.60586237
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60559468
98AMPK signaling pathway_Homo sapiens_hsa041520.59734508
99mTOR signaling pathway_Homo sapiens_hsa041500.59510213
100Nucleotide excision repair_Homo sapiens_hsa034200.59232774
101Renin-angiotensin system_Homo sapiens_hsa046140.59149728
102Focal adhesion_Homo sapiens_hsa045100.58835661
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58715171
104HIF-1 signaling pathway_Homo sapiens_hsa040660.58440565
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58224656
106Phenylalanine metabolism_Homo sapiens_hsa003600.56836450
107Estrogen signaling pathway_Homo sapiens_hsa049150.56416562
108Spliceosome_Homo sapiens_hsa030400.55654875
109Proteoglycans in cancer_Homo sapiens_hsa052050.55087302
110Folate biosynthesis_Homo sapiens_hsa007900.54746374
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54289526
112N-Glycan biosynthesis_Homo sapiens_hsa005100.52559697
113Cell cycle_Homo sapiens_hsa041100.52457063
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51623175
115ErbB signaling pathway_Homo sapiens_hsa040120.51277683
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.51037750
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.50680078
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50679097
119VEGF signaling pathway_Homo sapiens_hsa043700.50117885
120Autoimmune thyroid disease_Homo sapiens_hsa053200.49457784
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.48225082
122Rheumatoid arthritis_Homo sapiens_hsa053230.46900828
123GnRH signaling pathway_Homo sapiens_hsa049120.46723203
124Homologous recombination_Homo sapiens_hsa034400.45883017
125Pyrimidine metabolism_Homo sapiens_hsa002400.45687340
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43392439
127Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.43273131
128ECM-receptor interaction_Homo sapiens_hsa045120.43133001
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42979342
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.42888028
131African trypanosomiasis_Homo sapiens_hsa051430.40255266
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.40131874
133Non-small cell lung cancer_Homo sapiens_hsa052230.40038439

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