CORO1C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Three transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.35228335
2Golgi transport vesicle coating (GO:0048200)5.35228335
3cell adhesion mediated by integrin (GO:0033627)5.20605145
4barbed-end actin filament capping (GO:0051016)4.58116410
5skin morphogenesis (GO:0043589)4.32633548
6DNA unwinding involved in DNA replication (GO:0006268)4.05368375
7regulation of integrin activation (GO:0033623)4.02214178
8positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.80269255
9spliceosomal tri-snRNP complex assembly (GO:0000244)3.79341274
10stress fiber assembly (GO:0043149)3.76409454
11regulation of translational fidelity (GO:0006450)3.75360361
12endodermal cell differentiation (GO:0035987)3.74502555
13negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.68300049
14substrate-dependent cell migration (GO:0006929)3.67875554
15regulation of gene silencing by RNA (GO:0060966)3.62978889
16regulation of posttranscriptional gene silencing (GO:0060147)3.62978889
17regulation of gene silencing by miRNA (GO:0060964)3.62978889
18maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.56455227
19collagen fibril organization (GO:0030199)3.56273366
20regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.54024258
21dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.52161690
22wound healing, spreading of epidermal cells (GO:0035313)3.51727110
23negative regulation of smooth muscle cell migration (GO:0014912)3.49469846
24vesicle coating (GO:0006901)3.49456921
25protein retention in ER lumen (GO:0006621)3.47035420
26mitotic metaphase plate congression (GO:0007080)3.46954319
27establishment of apical/basal cell polarity (GO:0035089)3.44565353
28embryonic process involved in female pregnancy (GO:0060136)3.44180350
29apoptotic process involved in morphogenesis (GO:0060561)3.40991391
30cell-substrate junction assembly (GO:0007044)3.38138631
31formation of translation preinitiation complex (GO:0001731)3.33139584
32mitotic G1 DNA damage checkpoint (GO:0031571)3.32699794
33apoptotic cell clearance (GO:0043277)3.30565251
34retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.29344916
35retina vasculature morphogenesis in camera-type eye (GO:0061299)3.28600398
36peptidyl-arginine omega-N-methylation (GO:0035247)3.27533995
37establishment or maintenance of monopolar cell polarity (GO:0061339)3.26663007
38establishment of monopolar cell polarity (GO:0061162)3.26663007
39basement membrane organization (GO:0071711)3.25916275
40protein localization to kinetochore (GO:0034501)3.25559721
41DNA strand elongation involved in DNA replication (GO:0006271)3.24623829
42negative regulation of anoikis (GO:2000811)3.24280460
43positive regulation of SMAD protein import into nucleus (GO:0060391)3.22240394
44protein heterotrimerization (GO:0070208)3.22198752
45negative regulation of RNA splicing (GO:0033119)3.20037166
46positive regulation of receptor recycling (GO:0001921)3.19988786
47chondrocyte proliferation (GO:0035988)3.19116840
48regulation of integrin-mediated signaling pathway (GO:2001044)3.17429128
49cortical actin cytoskeleton organization (GO:0030866)3.16546254
50mesodermal cell differentiation (GO:0048333)3.15231159
51proline biosynthetic process (GO:0006561)3.14750422
52negative regulation of protein localization to plasma membrane (GO:1903077)3.12897262
53mitotic nuclear envelope disassembly (GO:0007077)3.12437790
54dosage compensation (GO:0007549)3.12072352
55regulation of SMAD protein import into nucleus (GO:0060390)3.10938283
56negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.10336536
57regulation of protein heterodimerization activity (GO:0043497)3.10049220
58pre-miRNA processing (GO:0031054)3.09140464
59negative regulation of mRNA processing (GO:0050686)3.08514039
60wound healing, spreading of cells (GO:0044319)3.07607307
61cell migration involved in sprouting angiogenesis (GO:0002042)3.07027950
62positive regulation of blood vessel endothelial cell migration (GO:0043536)3.06925602
63mitotic sister chromatid segregation (GO:0000070)3.05322377
64DNA strand elongation (GO:0022616)3.04988962
65hemidesmosome assembly (GO:0031581)3.03483927
66mitotic G1/S transition checkpoint (GO:0044819)3.02852319
67somatic hypermutation of immunoglobulin genes (GO:0016446)2.99529121
68somatic diversification of immune receptors via somatic mutation (GO:0002566)2.99529121
69membrane raft organization (GO:0031579)2.99514374
70positive regulation of chromosome segregation (GO:0051984)2.99465857
71heterochromatin organization (GO:0070828)2.98771797
72trophectodermal cell differentiation (GO:0001829)2.97344248
73nuclear envelope disassembly (GO:0051081)2.97297678
74membrane disassembly (GO:0030397)2.97297678
75regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.95638641
76adherens junction assembly (GO:0034333)2.94878412
77histone arginine methylation (GO:0034969)2.94649665
78regulation of hippo signaling (GO:0035330)2.93722464
79microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.93671429
80heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.93562776
81sister chromatid segregation (GO:0000819)2.90833276
82COPII vesicle coating (GO:0048208)2.90079189
83regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.87040416
84cell migration involved in heart development (GO:0060973)2.87012965
85hypotonic response (GO:0006971)2.86284184
86attachment of spindle microtubules to kinetochore (GO:0008608)2.85207012
87platelet aggregation (GO:0070527)2.84858305
88telomere maintenance via semi-conservative replication (GO:0032201)2.84280413
89extracellular fibril organization (GO:0043206)2.83673509
90cortical cytoskeleton organization (GO:0030865)2.83621377
91peptidyl-arginine N-methylation (GO:0035246)2.82906268
92peptidyl-arginine methylation (GO:0018216)2.82906268
93sprouting angiogenesis (GO:0002040)2.80255674
94establishment of chromosome localization (GO:0051303)2.79948471
95G1 DNA damage checkpoint (GO:0044783)2.78124086
96nuclear envelope reassembly (GO:0031468)2.77118680
97mitotic nuclear envelope reassembly (GO:0007084)2.77118680
98epithelial cell-cell adhesion (GO:0090136)2.77087044
99DNA geometric change (GO:0032392)2.76420022
100DNA replication-dependent nucleosome organization (GO:0034723)2.76405959
101DNA replication-dependent nucleosome assembly (GO:0006335)2.76405959
102positive regulation of axon extension (GO:0045773)2.74783365
103DNA duplex unwinding (GO:0032508)2.74392023
104collagen metabolic process (GO:0032963)2.72402261
105cellular response to vitamin (GO:0071295)2.72383130
106type B pancreatic cell proliferation (GO:0044342)2.71257883
107protein hydroxylation (GO:0018126)2.70494257
108negative regulation of chondrocyte differentiation (GO:0032331)2.70428155
109focal adhesion assembly (GO:0048041)2.70155820
110cell-substrate adherens junction assembly (GO:0007045)2.70155820
111chondroitin sulfate biosynthetic process (GO:0030206)2.70013150
112regulation of DNA damage checkpoint (GO:2000001)2.69619922
113paraxial mesoderm development (GO:0048339)2.69519063
114nuclear pore organization (GO:0006999)2.69074253
115base-excision repair (GO:0006284)2.69058792
116positive regulation of mitotic sister chromatid separation (GO:1901970)2.68595456
117positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.68595456
118positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.68595456
119nodal signaling pathway (GO:0038092)2.67869774
120nuclear envelope organization (GO:0006998)2.67618384
121kidney mesenchyme development (GO:0072074)2.67490484
122regulation of anoikis (GO:2000209)2.66553834
123regulation of sister chromatid cohesion (GO:0007063)2.66203963
124cellular copper ion homeostasis (GO:0006878)2.65557477
125DNA strand renaturation (GO:0000733)2.65272692
126regulation of early endosome to late endosome transport (GO:2000641)2.63860318
127actin filament depolymerization (GO:0030042)2.63818141
128metaphase plate congression (GO:0051310)2.63352446
129peptidyl-proline hydroxylation (GO:0019511)2.62752334
130replication fork processing (GO:0031297)2.62513292
131cellular response to vitamin D (GO:0071305)2.61841673
132negative regulation of mRNA metabolic process (GO:1903312)2.61163220
133viral mRNA export from host cell nucleus (GO:0046784)2.61103722
134DNA replication initiation (GO:0006270)2.60176993
135vascular endothelial growth factor signaling pathway (GO:0038084)2.59929285
136apoptotic process involved in development (GO:1902742)2.59853409
137hyaluronan catabolic process (GO:0030214)2.59733064
138pinocytosis (GO:0006907)2.59134488
139blood vessel endothelial cell migration (GO:0043534)2.57710688
140nerve growth factor signaling pathway (GO:0038180)2.56390945
141substrate adhesion-dependent cell spreading (GO:0034446)2.55841703
142platelet degranulation (GO:0002576)2.54743909
143positive regulation of endothelial cell apoptotic process (GO:2000353)2.54705505
144collagen catabolic process (GO:0030574)2.53439095
145nuclear pore complex assembly (GO:0051292)2.53251879
146fibril organization (GO:0097435)2.52774320
147regulation of RNA export from nucleus (GO:0046831)2.52176438
148nucleotide-excision repair, DNA gap filling (GO:0006297)2.50932284
149extracellular matrix assembly (GO:0085029)2.50157649
150mRNA cleavage (GO:0006379)2.50054563
151actin filament bundle assembly (GO:0051017)2.49606414
152actin filament bundle organization (GO:0061572)2.49606414
153negative regulation of stem cell proliferation (GO:2000647)2.48815890
154negative regulation of chromosome segregation (GO:0051985)2.47765133
155telomere maintenance via recombination (GO:0000722)2.47382909
156endocytic recycling (GO:0032456)2.46790595
157hippo signaling (GO:0035329)2.46734002
158regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.46586972
159maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.46548533
160cytoskeleton-dependent cytokinesis (GO:0061640)2.46152866
161negative regulation of nitric-oxide synthase activity (GO:0051001)2.45473644
162protein localization to endosome (GO:0036010)2.45135949
163multicellular organismal macromolecule metabolic process (GO:0044259)2.44073057
164SMAD protein complex assembly (GO:0007183)2.43668897
165protein localization to chromosome, centromeric region (GO:0071459)2.43091221
166mitotic recombination (GO:0006312)2.41248490
167regulation of metalloenzyme activity (GO:0048552)2.40533701
168muscle cell migration (GO:0014812)2.39756541
169regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.39376423
170histone H4-K12 acetylation (GO:0043983)2.38984801
171positive regulation of extracellular matrix organization (GO:1903055)2.38824285
172regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.38666142
173determination of adult lifespan (GO:0008340)2.38452468
174membrane protein ectodomain proteolysis (GO:0006509)2.37440302
175positive regulation of osteoblast proliferation (GO:0033690)2.37326452
176protein maturation by protein folding (GO:0022417)2.37156809
177spindle assembly (GO:0051225)2.35763890
178folic acid-containing compound biosynthetic process (GO:0009396)2.35708391
179Arp2/3 complex-mediated actin nucleation (GO:0034314)2.35338863
180activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.33602492
181mitotic chromosome condensation (GO:0007076)2.33472949
182developmental programmed cell death (GO:0010623)2.31554338
183negative regulation of cell cycle arrest (GO:0071157)2.31149021
184DNA topological change (GO:0006265)2.29524607
185positive regulation of T cell apoptotic process (GO:0070234)2.25857492
186spindle organization (GO:0007051)2.25333856
187negative regulation of JAK-STAT cascade (GO:0046426)2.25297775
188positive regulation of protein oligomerization (GO:0032461)2.24968581
189polarized epithelial cell differentiation (GO:0030859)2.23700015
190positive regulation of lymphocyte apoptotic process (GO:0070230)2.23475528
191intracellular estrogen receptor signaling pathway (GO:0030520)2.22921914
192regulation of chromosome segregation (GO:0051983)2.22692865
193termination of RNA polymerase II transcription (GO:0006369)2.22505780
194mRNA transport (GO:0051028)2.21741316
195telomere maintenance via telomere lengthening (GO:0010833)2.20305842

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.63699154
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.03714809
3WT1_19549856_ChIP-ChIP_CCG9911_Human3.68402262
4CLOCK_20551151_ChIP-Seq_293T_Human3.47322063
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.28294962
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.02634291
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.95303186
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.89952880
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.81368482
10* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.78817242
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.77117469
12* BRD4_25478319_ChIP-Seq_HGPS_Human2.71078710
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.68021919
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.50865582
15ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.48302022
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.46254372
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.45016859
18CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.36740144
19TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.36498661
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.29571391
21MYC_22102868_ChIP-Seq_BL_Human2.29387627
22SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.29176681
23WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.19066301
24* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.18248872
25* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.18248872
26VDR_21846776_ChIP-Seq_THP-1_Human2.17060371
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.15909687
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.04536321
29KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.03076952
30KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.03076952
31KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.03076952
32* KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.00975362
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.00036548
34ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.93774367
35Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.92281116
36GATA2_21666600_ChIP-Seq_HMVEC_Human1.92252041
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.91246229
38PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.85124585
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.84351998
40CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.83091735
41SALL4_18804426_ChIP-ChIP_XEN_Mouse1.81020883
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.74975470
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72913939
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.69833520
45SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.69688165
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68800929
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67825139
48TCF3_18692474_ChIP-Seq_MEFs_Mouse1.64413604
49NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.62109597
50ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.62103131
51JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61363528
52* CJUN_26792858_Chip-Seq_BT549_Human1.60957993
53UBF1/2_26484160_Chip-Seq_HMECs_Human1.60368153
54* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.59465209
55EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.59039113
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.58144161
57SOX9_24532713_ChIP-Seq_HFSC_Mouse1.56952969
58NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56344499
59SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.55828415
60* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.54293067
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52279412
62XRN2_22483619_ChIP-Seq_HELA_Human1.50872721
63* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.49035951
64NFIB_24661679_ChIP-Seq_LUNG_Mouse1.48995212
65* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.48681664
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46480647
67TFEB_21752829_ChIP-Seq_HELA_Human1.44740238
68AR_21909140_ChIP-Seq_LNCAP_Human1.44415159
69KDM2B_26808549_Chip-Seq_DND41_Human1.43491446
70KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41034677
71* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40979900
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.40440528
73NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40219609
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40219609
75PPAR_26484153_Chip-Seq_NCI-H1993_Human1.39396715
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.39307584
77NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.37819391
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37384174
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36754876
80JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34692258
81MYCN_18555785_ChIP-Seq_MESCs_Mouse1.33910708
82* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33863552
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32823817
84ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31767846
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.31728333
86TCF3_18692474_ChIP-Seq_MESCs_Mouse1.31466289
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31257572
88EP300_21415370_ChIP-Seq_HL-1_Mouse1.29391336
89* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28110391
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.26794880
91* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26471086
92P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26059979
93LXR_22292898_ChIP-Seq_THP-1_Human1.25346115
94MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.24918461
95NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24643076
96TP53_18474530_ChIP-ChIP_U2OS_Human1.24365169
97TTF2_22483619_ChIP-Seq_HELA_Human1.22777308
98NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.22364411
99* ATF3_27146783_Chip-Seq_COLON_Human1.21882933
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20763943
101CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.20464113
102TCF7_22412390_ChIP-Seq_EML_Mouse1.20195981
103* RACK7_27058665_Chip-Seq_MCF-7_Human1.19994093
104ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18114417
105* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18073008
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17582185
107SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17086727
108* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.17034858
109SMC1_22415368_ChIP-Seq_MEFs_Mouse1.16645668
110TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16455598
111ETS1_20019798_ChIP-Seq_JURKAT_Human1.15867851
112KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15542748
113TP63_19390658_ChIP-ChIP_HaCaT_Human1.14874686
114STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14843438
115SOX17_20123909_ChIP-Seq_XEN_Mouse1.14053004
116SALL1_21062744_ChIP-ChIP_HESCs_Human1.12830710
117GATA4_21415370_ChIP-Seq_HL-1_Mouse1.12789756
118NANOG_21062744_ChIP-ChIP_HESCs_Human1.12768627
119* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12731177
120* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12593090
121TP53_22127205_ChIP-Seq_IMR90_Human1.12288478
122NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12089788
123OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12060574
124DCP1A_22483619_ChIP-Seq_HELA_Human1.12010401
125* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11989840
126* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11344508
127KDM5A_27292631_Chip-Seq_BREAST_Human1.11125839
128* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10884144
129ZNF263_19887448_ChIP-Seq_K562_Human1.10841519
130FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.10703025
131CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09799251
132POU5F1_16518401_ChIP-PET_MESCs_Mouse1.07643956
133* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07295945
134MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07056915
135SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06273220
136THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05802802
137ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04638326
138SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04599080
139TBX20_22080862_ChIP-Seq_HEART_Mouse1.04330343
140TBX20_22328084_ChIP-Seq_HEART_Mouse1.04330343
141TP53_16413492_ChIP-PET_HCT116_Human1.02943129
142GABP_19822575_ChIP-Seq_HepG2_Human1.02762895
143SOX2_18692474_ChIP-Seq_MEFs_Mouse1.02283745
144TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01387479
145UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00975301
146THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00774720
147STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98100625
148HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96879690
149PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.96513998
150CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95964398
151RARG_19884340_ChIP-ChIP_MEFs_Mouse0.95836668
152CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94532353
153MAF_26560356_Chip-Seq_TH1_Human0.94488539
154UTX_26944678_Chip-Seq_JUKART_Human0.94270027
155TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93691114
156SA1_22415368_ChIP-Seq_MEFs_Mouse0.93312773
157* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91085989
158RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90421139
159* TP53_23651856_ChIP-Seq_MEFs_Mouse0.90091745

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane3.63429683
2MP0010352_gastrointestinal_tract_polyps3.52654125
3MP0002877_abnormal_melanocyte_morpholog3.16019857
4MP0005076_abnormal_cell_differentiation2.92154421
5MP0003705_abnormal_hypodermis_morpholog2.78907215
6MP0009278_abnormal_bone_marrow2.69206769
7MP0003279_aneurysm2.67675990
8MP0003111_abnormal_nucleus_morphology2.65292370
9MP0003566_abnormal_cell_adhesion2.43446622
10MP0004957_abnormal_blastocyst_morpholog2.42989367
11MP0010094_abnormal_chromosome_stability2.29016085
12MP0010368_abnormal_lymphatic_system2.26876423
13MP0003693_abnormal_embryo_hatching2.25292587
14MP0003077_abnormal_cell_cycle2.21095040
15MP0008057_abnormal_DNA_replication2.18847780
16MP0010030_abnormal_orbit_morphology2.08315930
17MP0001730_embryonic_growth_arrest1.95415531
18MP0001542_abnormal_bone_strength1.90908563
19MP0010307_abnormal_tumor_latency1.85470825
20MP0003191_abnormal_cellular_cholesterol1.81358643
21MP0008932_abnormal_embryonic_tissue1.79366925
22MP0008438_abnormal_cutaneous_collagen1.74889057
23MP0000350_abnormal_cell_proliferation1.74066949
24MP0000537_abnormal_urethra_morphology1.74019507
25MP0005058_abnormal_lysosome_morphology1.73375467
26MP0000569_abnormal_digit_pigmentation1.72555439
27MP0002653_abnormal_ependyma_morphology1.69603006
28MP0002084_abnormal_developmental_patter1.69043376
29MP0000490_abnormal_crypts_of1.66224631
30MP0004197_abnormal_fetal_growth/weight/1.62543047
31MP0001697_abnormal_embryo_size1.62006414
32MP0000767_abnormal_smooth_muscle1.61917605
33MP0003941_abnormal_skin_development1.61725002
34MP0002085_abnormal_embryonic_tissue1.61052917
35MP0003172_abnormal_lysosome_physiology1.57884646
36MP0002086_abnormal_extraembryonic_tissu1.56482693
37MP0004233_abnormal_muscle_weight1.54281636
38MP0001849_ear_inflammation1.50367926
39MP0001299_abnormal_eye_distance/1.49769831
40MP0005380_embryogenesis_phenotype1.49664856
41MP0001672_abnormal_embryogenesis/_devel1.49664856
42MP0003119_abnormal_digestive_system1.48547187
43MP0002060_abnormal_skin_morphology1.43600720
44MP0003890_abnormal_embryonic-extraembry1.40599290
45MP0003303_peritoneal_inflammation1.40488802
46MP0002896_abnormal_bone_mineralization1.39555271
47MP0005023_abnormal_wound_healing1.39415397
48MP0005503_abnormal_tendon_morphology1.38966830
49MP0009384_cardiac_valve_regurgitation1.37932657
50MP0005257_abnormal_intraocular_pressure1.36532968
51MP0002080_prenatal_lethality1.35936665
52MP0003984_embryonic_growth_retardation1.33942637
53MP0003091_abnormal_cell_migration1.33713339
54MP0005595_abnormal_vascular_smooth1.33642987
55MP0002088_abnormal_embryonic_growth/wei1.32897818
56MP0005171_absent_coat_pigmentation1.32778561
57MP0008007_abnormal_cellular_replicative1.32666941
58MP0003567_abnormal_fetal_cardiomyocyte1.29736187
59MP0008260_abnormal_autophagy1.28764288
60MP0009840_abnormal_foam_cell1.28490390
61MP0003448_altered_tumor_morphology1.27907299
62MP0000343_altered_response_to1.27211088
63MP0009053_abnormal_anal_canal1.22711647
64MP0005623_abnormal_meninges_morphology1.19682796
65MP0001545_abnormal_hematopoietic_system1.19464450
66MP0005397_hematopoietic_system_phenotyp1.19464450
67MP0003453_abnormal_keratinocyte_physiol1.18626473
68MP0000733_abnormal_muscle_development1.16855877
69MP0008789_abnormal_olfactory_epithelium1.15926778
70MP0002111_abnormal_tail_morphology1.15719401
71MP0003300_gastrointestinal_ulcer1.15199461
72MP0005174_abnormal_tail_pigmentation1.15152657
73MP0004883_abnormal_blood_vessel1.14857265
74MP0003385_abnormal_body_wall1.13788256
75MP0000013_abnormal_adipose_tissue1.13171754
76MP0003283_abnormal_digestive_organ1.11852684
77MP0010234_abnormal_vibrissa_follicle1.11034680
78MP0005164_abnormal_response_to1.10727144
79MP0001293_anophthalmia1.10044813
80MP0000534_abnormal_ureter_morphology1.08202666
81MP0006054_spinal_hemorrhage1.06622663
82MP0005464_abnormal_platelet_physiology1.06599853
83MP0000749_muscle_degeneration1.05888018
84MP0001243_abnormal_dermal_layer1.05783438
85MP0003221_abnormal_cardiomyocyte_apopto1.04198749
86MP0004133_heterotaxia1.03993146
87MP0000751_myopathy1.02200369
88MP0001879_abnormal_lymphatic_vessel1.01600199
89MP0005197_abnormal_uvea_morphology1.01153160
90MP0005451_abnormal_body_composition1.01105878
91MP0003123_paternal_imprinting1.00825159
92MP0004858_abnormal_nervous_system1.00137908
93MP0002282_abnormal_trachea_morphology0.99921285
94MP0005394_taste/olfaction_phenotype0.97866363
95MP0005499_abnormal_olfactory_system0.97866363
96MP0000467_abnormal_esophagus_morphology0.97694824
97MP0001915_intracranial_hemorrhage0.97099766
98MP0000759_abnormal_skeletal_muscle0.95689909
99MP0001958_emphysema0.94869802
100MP0002295_abnormal_pulmonary_circulatio0.94039314
101MP0009333_abnormal_splenocyte_physiolog0.93861690
102MP0002925_abnormal_cardiovascular_devel0.93540072
103MP0000313_abnormal_cell_death0.92505078
104MP0002019_abnormal_tumor_incidence0.92494867
105MP0000858_altered_metastatic_potential0.92089230
106MP0000432_abnormal_head_morphology0.92076562
107MP0002396_abnormal_hematopoietic_system0.91629098
108MP0000477_abnormal_intestine_morphology0.91318303
109MP0005409_darkened_coat_color0.91267391
110MP0005275_abnormal_skin_tensile0.90633067
111MP0002751_abnormal_autonomic_nervous0.90036385
112MP0005501_abnormal_skin_physiology0.89820032
113MP0003755_abnormal_palate_morphology0.88076070
114MP0005193_abnormal_anterior_eye0.87804464
115MP0003935_abnormal_craniofacial_develop0.87273656
116MP0002128_abnormal_blood_circulation0.86515013
117MP0008058_abnormal_DNA_repair0.86434200
118MP0000462_abnormal_digestive_system0.86261630
119MP0000428_abnormal_craniofacial_morphol0.86072854
120MP0004084_abnormal_cardiac_muscle0.86002376
121MP0003861_abnormal_nervous_system0.84837321
122MP0001614_abnormal_blood_vessel0.84575339
123MP0000762_abnormal_tongue_morphology0.84200124
124MP0000015_abnormal_ear_pigmentation0.82466776
125MP0001529_abnormal_vocalization0.81645641
126MP0000003_abnormal_adipose_tissue0.81022926
127MP0000465_gastrointestinal_hemorrhage0.80696665
128MP0003329_amyloid_beta_deposits0.80611524
129MP0004808_abnormal_hematopoietic_stem0.80542841
130MP0002697_abnormal_eye_size0.79918280
131MP0002796_impaired_skin_barrier0.79807271
132MP0000747_muscle_weakness0.79481428
133MP0005367_renal/urinary_system_phenotyp0.79030734
134MP0000516_abnormal_urinary_system0.79030734
135MP0005621_abnormal_cell_physiology0.78975002
136MP0000371_diluted_coat_color0.78848202
137MP0002092_abnormal_eye_morphology0.78441669
138MP0003115_abnormal_respiratory_system0.78295825
139MP0004087_abnormal_muscle_fiber0.78106697
140MP0003828_pulmonary_edema0.77653068
141MP0002998_abnormal_bone_remodeling0.76994992
142MP0005508_abnormal_skeleton_morphology0.76390108
143MP0003942_abnormal_urinary_system0.76294981
144MP0009250_abnormal_appendicular_skeleto0.75004262
145MP0002116_abnormal_craniofacial_bone0.74306815
146MP0004272_abnormal_basement_membrane0.74075491
147MP0005388_respiratory_system_phenotype0.72985850
148MP0002133_abnormal_respiratory_system0.72985850
149MP0000358_abnormal_cell_content/0.72459516
150MP0005384_cellular_phenotype0.71594042
151MP0003786_premature_aging0.71093446
152MP0008770_decreased_survivor_rate0.71020990
153MP0000383_abnormal_hair_follicle0.70449343
154MP0002113_abnormal_skeleton_development0.69974220
155MP0002177_abnormal_outer_ear0.65560010
156MP0006138_congestive_heart_failure0.65127003

Predicted human phenotypes

RankGene SetZ-score
1Aortic dissection (HP:0002647)3.94101984
2Vascular tortuosity (HP:0004948)3.84516290
3Arterial tortuosity (HP:0005116)3.71527001
4Cerebral aneurysm (HP:0004944)3.37971140
5Spinal rigidity (HP:0003306)3.24125114
6Osteolytic defects of the hand bones (HP:0009699)3.04401570
7Osteolytic defects of the phalanges of the hand (HP:0009771)3.04401570
8Abnormality of dentin (HP:0010299)2.97524632
9Spondylolisthesis (HP:0003302)2.96665197
10Wormian bones (HP:0002645)2.94940248
11Distal lower limb amyotrophy (HP:0008944)2.87507921
12Soft skin (HP:0000977)2.87419951
13Selective tooth agenesis (HP:0001592)2.80715825
14Follicular hyperkeratosis (HP:0007502)2.76593643
15Vertebral compression fractures (HP:0002953)2.75628160
16Fragile skin (HP:0001030)2.75162491
17Ulnar bowing (HP:0003031)2.65817536
18Rib fusion (HP:0000902)2.61173157
19Increased mean platelet volume (HP:0011877)2.59168406
20Short humerus (HP:0005792)2.58102876
21Agnosia (HP:0010524)2.56493886
22Aplasia/hypoplasia of the humerus (HP:0006507)2.55541613
23Astrocytoma (HP:0009592)2.53956772
24Abnormality of the astrocytes (HP:0100707)2.53956772
25Shallow orbits (HP:0000586)2.53938639
26Spinal muscular atrophy (HP:0007269)2.53768586
27Cortical dysplasia (HP:0002539)2.51862263
28Lower limb amyotrophy (HP:0007210)2.51316209
29Abnormal gallbladder physiology (HP:0012438)2.51108395
30Cholecystitis (HP:0001082)2.51108395
31Blue sclerae (HP:0000592)2.50840296
32Mitral valve prolapse (HP:0001634)2.45892062
33Ependymoma (HP:0002888)2.43855978
34Neonatal short-limb short stature (HP:0008921)2.40293933
35Facial hemangioma (HP:0000329)2.39452700
36Vertebral hypoplasia (HP:0008417)2.39411743
37Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.39411743
38Myocardial infarction (HP:0001658)2.38948690
39Achilles tendon contracture (HP:0001771)2.37761497
40Wrist flexion contracture (HP:0001239)2.35237249
41Patellar aplasia (HP:0006443)2.34262872
42Premature rupture of membranes (HP:0001788)2.32786922
43Increased cerebral lipofuscin (HP:0011813)2.30224665
44Protrusio acetabuli (HP:0003179)2.30139438
45Short nail (HP:0001799)2.28221131
46Deviation of the thumb (HP:0009603)2.28108140
47Abnormal platelet volume (HP:0011876)2.27455894
48Short 4th metacarpal (HP:0010044)2.26078687
49Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.26078687
50Mitral stenosis (HP:0001718)2.25792262
51Disproportionate tall stature (HP:0001519)2.24173768
52Mitral regurgitation (HP:0001653)2.23503178
53Absent radius (HP:0003974)2.23091585
54Abnormality of liposaccharide metabolism (HP:0010968)2.21653566
55Abnormality of glycosphingolipid metabolism (HP:0004343)2.21653566
56Abnormality of glycolipid metabolism (HP:0010969)2.21653566
57Degeneration of anterior horn cells (HP:0002398)2.21478332
58Abnormality of the anterior horn cell (HP:0006802)2.21478332
59Proximal placement of thumb (HP:0009623)2.20008625
60Natal tooth (HP:0000695)2.19711626
61Increased density of long bones (HP:0006392)2.18672766
62Esophageal atresia (HP:0002032)2.15102316
63Aplasia/Hypoplasia of the patella (HP:0006498)2.12916883
64Upper limb muscle weakness (HP:0003484)2.12380941
65Joint laxity (HP:0001388)2.11433396
66Absent forearm bone (HP:0003953)2.11289072
67Aplasia involving forearm bones (HP:0009822)2.11289072
68Abnormality of the Achilles tendon (HP:0005109)2.10734555
69Genu recurvatum (HP:0002816)2.10110463
70Abnormality of the labia minora (HP:0012880)2.10056391
71Slender build (HP:0001533)2.09914390
72Annular pancreas (HP:0001734)2.05810117
73Elbow flexion contracture (HP:0002987)2.05170953
74Hyperacusis (HP:0010780)2.04437284
75Pustule (HP:0200039)2.04378078
76Increased connective tissue (HP:0009025)2.03893986
77Insidious onset (HP:0003587)2.03316834
78Termporal pattern (HP:0011008)2.03316834
79Syringomyelia (HP:0003396)2.02074473
80Spinal cord lesions (HP:0100561)2.02074473
81Rectovaginal fistula (HP:0000143)2.01308061
82Rectal fistula (HP:0100590)2.01308061
83Insomnia (HP:0100785)2.00340413
84Hyperextensible skin (HP:0000974)2.00019123
85Colon cancer (HP:0003003)1.97920153
86Abnormality of the calcaneus (HP:0008364)1.97367888
87Aortic regurgitation (HP:0001659)1.97049354
88Abnormality of the acetabulum (HP:0003170)1.96778578
89Aneurysm (HP:0002617)1.96627895
90Reduced subcutaneous adipose tissue (HP:0003758)1.96294050
91Increased variability in muscle fiber diameter (HP:0003557)1.96280434
92Wide anterior fontanel (HP:0000260)1.94085795
93Back pain (HP:0003418)1.89719837
94Orthostatic hypotension (HP:0001278)1.89529185
95Abnormal delivery (HP:0001787)1.89332264
96Abnormality of the musculature of the pelvis (HP:0001469)1.89270255
97Abnormality of the hip-girdle musculature (HP:0001445)1.89270255
98Basal cell carcinoma (HP:0002671)1.89233792
99Turricephaly (HP:0000262)1.88941290
100Limb-girdle muscle atrophy (HP:0003797)1.88865122
101Tongue fasciculations (HP:0001308)1.87091747
102Limb-girdle muscle weakness (HP:0003325)1.86959140
103Malignant gastrointestinal tract tumors (HP:0006749)1.86912880
104Gastrointestinal carcinoma (HP:0002672)1.86912880
105Abnormality of skeletal muscle fiber size (HP:0012084)1.86233918
106Hammertoe (HP:0001765)1.86104256
107Flat cornea (HP:0007720)1.85274018
108Atrophy/Degeneration involving motor neurons (HP:0007373)1.84690048
109Peritonitis (HP:0002586)1.84244428
110Alopecia of scalp (HP:0002293)1.83864739
111Hand muscle atrophy (HP:0009130)1.83852534
112Muscle fibrillation (HP:0010546)1.82873228
113Entropion (HP:0000621)1.81926224
114Ankle contracture (HP:0006466)1.81544944
115Pelvic girdle muscle weakness (HP:0003749)1.81446941
116Dysostosis multiplex (HP:0000943)1.81173112
117Type 1 muscle fiber predominance (HP:0003803)1.81009684
118Intestinal fistula (HP:0100819)1.79971220
119Camptodactyly of toe (HP:0001836)1.79964109
120Tetraparesis (HP:0002273)1.79847757
121Congenital hip dislocation (HP:0001374)1.78969581
122Absent frontal sinuses (HP:0002688)1.78957614
123Shoulder girdle muscle weakness (HP:0003547)1.78932572
124Disinhibition (HP:0000734)1.78616593
125Glioma (HP:0009733)1.78484322
126Delayed closure of the anterior fontanelle (HP:0001476)1.77395738
127Hypoventilation (HP:0002791)1.76845542
128Increased neuronal autofluorescent lipopigment (HP:0002074)1.75614042
129Long palpebral fissure (HP:0000637)1.75588526
130Vertebral arch anomaly (HP:0008438)1.74769705
131Bowel diverticulosis (HP:0005222)1.74368788
132Neoplasm of the oral cavity (HP:0100649)1.74138649
133Cervical subluxation (HP:0003308)1.73965077
134Mucopolysacchariduria (HP:0008155)1.73497678
135Urinary glycosaminoglycan excretion (HP:0003541)1.73497678
136Upper motor neuron abnormality (HP:0002127)1.73461305
137Distal upper limb amyotrophy (HP:0007149)1.72611752
138Upper limb amyotrophy (HP:0009129)1.72611752
139Distal lower limb muscle weakness (HP:0009053)1.72449805
140Delayed cranial suture closure (HP:0000270)1.71821907
141Vaginal fistula (HP:0004320)1.71434593
142Breech presentation (HP:0001623)1.70970983
143Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.70396646
144Broad metatarsal (HP:0001783)1.70208042
145Breast hypoplasia (HP:0003187)1.69339170
146Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.69179657
147Medulloblastoma (HP:0002885)1.69143425
148Relative macrocephaly (HP:0004482)1.69104344
149Coronal craniosynostosis (HP:0004440)1.68042443
150Poikiloderma (HP:0001029)1.67290501
151Bladder diverticulum (HP:0000015)1.66704624
152Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.66596731
153Personality changes (HP:0000751)1.65881992
154Difficulty climbing stairs (HP:0003551)1.64677018
155Dilatation of the ascending aorta (HP:0005111)1.64636681
156Trismus (HP:0000211)1.64395754
157Gastrointestinal atresia (HP:0002589)1.64227464
158Diminished motivation (HP:0000745)1.64080413
159Absent thumb (HP:0009777)1.63449508
160Bicuspid aortic valve (HP:0001647)1.63175894
161Vertebral fusion (HP:0002948)1.62261585
162Aortic aneurysm (HP:0004942)1.61739315
163Bowed forearm bones (HP:0003956)1.61611818
164Bowing of the arm (HP:0006488)1.61611818
165Concave nail (HP:0001598)1.61149043
166Abdominal situs inversus (HP:0003363)1.60247572
167Abnormality of abdominal situs (HP:0011620)1.60247572
168Volvulus (HP:0002580)1.59425003
169Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.59175953
170Abnormality of mucopolysaccharide metabolism (HP:0011020)1.58752549
171Abnormality of polysaccharide metabolism (HP:0011012)1.58752549
172Abnormality of glycosaminoglycan metabolism (HP:0004371)1.58752549
173Atrophic scars (HP:0001075)1.58555073
174Apathy (HP:0000741)1.58503413
175Missing ribs (HP:0000921)1.57285217
176Renal duplication (HP:0000075)1.56714314
177Broad thumb (HP:0011304)1.55851937

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK33.23892706
2ICK3.19365973
3DDR22.78416497
4EPHA22.75732245
5MYLK2.45534579
6TRIB32.43999479
7MAP3K112.31002649
8ERBB42.29113558
9TESK22.15860672
10MAP3K102.15771437
11CDC72.01269550
12NTRK12.00557032
13LIMK12.00506458
14BMX1.98196537
15NEK91.97483562
16EEF2K1.95553078
17TYRO31.95346406
18TESK11.95196067
19MOS1.94893414
20PKN21.94441278
21FGR1.93327509
22STK101.92429507
23CDK121.91635901
24PDGFRA1.89333904
25BUB11.84245092
26SCYL21.70908390
27TTN1.68115160
28CDK71.65606202
29MATK1.61959864
30WEE11.61463929
31PAK41.58763037
32NEK21.56701852
33NEK11.50885693
34RPS6KB21.50298696
35EPHB11.44000846
36PIM21.42420086
37LATS21.33873473
38BCR1.28775930
39MAP3K61.28400370
40CDK61.26452466
41LRRK21.24389254
42MAP3K81.21312968
43KSR11.19468431
44BLK1.19462252
45DYRK1B1.19132284
46TTK1.19081036
47ROCK21.17216668
48PLK11.16809009
49CCNB11.16328687
50EPHB21.15721578
51YES11.14239689
52PAK21.12070627
53ALK1.11970748
54EIF2AK11.11576460
55CDK81.10186772
56LATS11.08583039
57PAK61.07134103
58ERBB31.04946958
59PRPF4B1.04576776
60ARAF1.04111673
61MTOR1.02770841
62FGFR11.02757312
63CSK1.02609332
64UHMK11.02193087
65LMTK21.01225143
66PTK20.98774970
67KSR20.98120904
68DYRK20.97118171
69CHEK20.94890530
70TSSK60.93782617
71AURKA0.92870600
72PAK10.92403278
73FLT30.91167259
74RIPK10.90278686
75ATR0.87364339
76TGFBR10.86679615
77PIM10.85297191
78AURKB0.84212630
79CLK10.83681027
80PTK60.83660338
81ABL20.83275525
82VRK20.83267024
83RPS6KC10.81453734
84RPS6KL10.81453734
85STK38L0.81307077
86DAPK10.79984842
87MST1R0.76643602
88RPS6KA40.76249045
89PTK2B0.76026962
90SIK20.74222739
91RAF10.73792575
92RPS6KA20.72793847
93PBK0.72701577
94DYRK30.71392838
95CHEK10.71377970
96KDR0.70872338
97MUSK0.70169700
98ROCK10.68476432
99RPS6KA60.68333769
100PRKG20.67977714
101MAP3K50.67751119
102PLK20.66958837
103CDK20.66077511
104TRPM70.65502528
105GSK3A0.64601351
106CDK90.63901237
107STK380.63762837
108NME20.63487496
109CDK40.62787496
110EGFR0.61700516
111SMG10.60900725
112TAOK10.60698299
113DAPK30.60678451
114MAP2K30.60382120
115SRPK10.59673540
116STK30.59221820
117TIE10.58840918
118MAP2K20.56958644
119ILK0.56868158
120RPS6KA10.56021919
121PDGFRB0.55483561
122MELK0.55479771
123MET0.54114955
124STK240.53720849
125CDK140.53424018
126MARK10.52839816
127MAP3K30.51666981
128TGFBR20.51649399
129CDK150.50927127
130CDK11A0.49882850
131PLK30.49491472
132PRKD20.49458281
133CDK180.48745374
134MAP3K90.48567875
135ERN10.48181639
136MKNK10.46646376
137DMPK0.46634252
138SIK30.46272098
139MAPKAPK20.46138176
140FER0.44741655
141CDK10.44491711
142GRK70.42119379
143ATM0.41803932
144MAPK150.41060091
145PRKD10.40082622
146BRSK10.38370526
147TAOK20.37251417
148MAP2K10.35282113
149CDC42BPA0.35168740
150BRD40.34656478
151AKT20.33622602
152MAP3K140.33297364
153CSNK1A1L0.32867167

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034302.97293841
2DNA replication_Homo sapiens_hsa030302.94351486
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.64042052
4Base excision repair_Homo sapiens_hsa034102.38552155
5Spliceosome_Homo sapiens_hsa030402.13435740
6Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.07658408
7Cell cycle_Homo sapiens_hsa041102.06422496
8RNA transport_Homo sapiens_hsa030132.03378128
9Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.95947393
10Shigellosis_Homo sapiens_hsa051311.88253156
11Vibrio cholerae infection_Homo sapiens_hsa051101.86557781
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.78240049
13Adherens junction_Homo sapiens_hsa045201.72708043
14Hippo signaling pathway_Homo sapiens_hsa043901.71254483
15Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.70013047
16p53 signaling pathway_Homo sapiens_hsa041151.67295374
17Notch signaling pathway_Homo sapiens_hsa043301.58804574
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.56063209
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54250823
20Nucleotide excision repair_Homo sapiens_hsa034201.52861004
21Colorectal cancer_Homo sapiens_hsa052101.52196992
22MicroRNAs in cancer_Homo sapiens_hsa052061.48623625
23Chronic myeloid leukemia_Homo sapiens_hsa052201.46658709
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.43739351
25mRNA surveillance pathway_Homo sapiens_hsa030151.41789414
26Bladder cancer_Homo sapiens_hsa052191.38719807
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.35073234
28Viral myocarditis_Homo sapiens_hsa054161.33828599
29Small cell lung cancer_Homo sapiens_hsa052221.29232923
30Viral carcinogenesis_Homo sapiens_hsa052031.29015405
31Proteoglycans in cancer_Homo sapiens_hsa052051.24278219
32Homologous recombination_Homo sapiens_hsa034401.23291176
33Hedgehog signaling pathway_Homo sapiens_hsa043401.20640543
34Regulation of actin cytoskeleton_Homo sapiens_hsa048101.20139149
35mTOR signaling pathway_Homo sapiens_hsa041501.19348052
36Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.18383569
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.17153688
38Basal cell carcinoma_Homo sapiens_hsa052171.14469031
39Salmonella infection_Homo sapiens_hsa051321.11768046
40Focal adhesion_Homo sapiens_hsa045101.10272246
41Apoptosis_Homo sapiens_hsa042101.09667552
42TGF-beta signaling pathway_Homo sapiens_hsa043501.08512075
43Dilated cardiomyopathy_Homo sapiens_hsa054141.08248488
44Lysosome_Homo sapiens_hsa041421.07480881
45Prion diseases_Homo sapiens_hsa050201.06130917
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.04688768
47HTLV-I infection_Homo sapiens_hsa051661.04445640
48Epstein-Barr virus infection_Homo sapiens_hsa051691.02863712
49Pentose phosphate pathway_Homo sapiens_hsa000301.01236139
50Proteasome_Homo sapiens_hsa030501.01027834
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00113592
52One carbon pool by folate_Homo sapiens_hsa006700.99488116
53VEGF signaling pathway_Homo sapiens_hsa043700.99434509
54Tight junction_Homo sapiens_hsa045300.99425590
55Oocyte meiosis_Homo sapiens_hsa041140.99099916
56Endocytosis_Homo sapiens_hsa041440.98986213
57Endometrial cancer_Homo sapiens_hsa052130.98976010
58Pancreatic cancer_Homo sapiens_hsa052120.98554575
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98271238
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94510288
61Legionellosis_Homo sapiens_hsa051340.94469752
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94328581
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94063450
64Phagosome_Homo sapiens_hsa041450.92583182
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92546680
66Galactose metabolism_Homo sapiens_hsa000520.86722555
67Fanconi anemia pathway_Homo sapiens_hsa034600.86368737
68Hepatitis B_Homo sapiens_hsa051610.83451650
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83164858
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82841601
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81684079
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.81431027
73Renal cell carcinoma_Homo sapiens_hsa052110.80918714
74Pathways in cancer_Homo sapiens_hsa052000.80783390
75Antigen processing and presentation_Homo sapiens_hsa046120.80324129
76Sulfur metabolism_Homo sapiens_hsa009200.79395384
77Wnt signaling pathway_Homo sapiens_hsa043100.77510222
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76739886
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.76466259
80Malaria_Homo sapiens_hsa051440.76207218
81Thyroid cancer_Homo sapiens_hsa052160.75602797
82Steroid biosynthesis_Homo sapiens_hsa001000.74553657
83Biosynthesis of amino acids_Homo sapiens_hsa012300.73760633
84Ribosome_Homo sapiens_hsa030100.73686032
85Leishmaniasis_Homo sapiens_hsa051400.73647266
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.73568134
87Acute myeloid leukemia_Homo sapiens_hsa052210.72134173
88HIF-1 signaling pathway_Homo sapiens_hsa040660.71647325
89Other glycan degradation_Homo sapiens_hsa005110.70036030
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68786334
91ECM-receptor interaction_Homo sapiens_hsa045120.67798324
92Non-small cell lung cancer_Homo sapiens_hsa052230.66773235
93Sphingolipid metabolism_Homo sapiens_hsa006000.64025984
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63860987
95Gap junction_Homo sapiens_hsa045400.63492717
96Axon guidance_Homo sapiens_hsa043600.62443409
97Rap1 signaling pathway_Homo sapiens_hsa040150.61545318
98Osteoclast differentiation_Homo sapiens_hsa043800.60699184
99Glioma_Homo sapiens_hsa052140.60492420
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59999583
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59966078
102Amoebiasis_Homo sapiens_hsa051460.59935272
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59739183
104N-Glycan biosynthesis_Homo sapiens_hsa005100.59355073
105Melanoma_Homo sapiens_hsa052180.58043570
106Herpes simplex infection_Homo sapiens_hsa051680.57977101
107Estrogen signaling pathway_Homo sapiens_hsa049150.56915432
108ErbB signaling pathway_Homo sapiens_hsa040120.56756456
109B cell receptor signaling pathway_Homo sapiens_hsa046620.56531858
110Prostate cancer_Homo sapiens_hsa052150.56217057
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55918750
112Toxoplasmosis_Homo sapiens_hsa051450.55810022
113Tuberculosis_Homo sapiens_hsa051520.55406275
114TNF signaling pathway_Homo sapiens_hsa046680.55083668
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54967327
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.54642850
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54032631
118Platelet activation_Homo sapiens_hsa046110.54024931
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53766200
120Measles_Homo sapiens_hsa051620.52784589
121Renin-angiotensin system_Homo sapiens_hsa046140.52684730
122Systemic lupus erythematosus_Homo sapiens_hsa053220.52298321
123Pertussis_Homo sapiens_hsa051330.50409877
124RNA polymerase_Homo sapiens_hsa030200.50217988
125AMPK signaling pathway_Homo sapiens_hsa041520.48998766
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48106975
127Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47334142
128Fructose and mannose metabolism_Homo sapiens_hsa000510.47210067
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44848110
130Ras signaling pathway_Homo sapiens_hsa040140.44846072
1312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43700314
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43567958
133Insulin signaling pathway_Homo sapiens_hsa049100.42177402

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