CORO2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.99439639
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.99439639
3antigen processing and presentation of endogenous antigen (GO:0019883)6.45113308
4regulation of guanylate cyclase activity (GO:0031282)5.32864097
5intestinal absorption (GO:0050892)5.28812585
6bundle of His cell to Purkinje myocyte communication (GO:0086069)5.10751754
7positive regulation of gamma-delta T cell activation (GO:0046645)4.94973333
8desmosome organization (GO:0002934)4.90791506
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.84871536
10vitamin transmembrane transport (GO:0035461)4.71080269
11glucuronate metabolic process (GO:0019585)4.54721042
12uronic acid metabolic process (GO:0006063)4.54721042
13cellular glucuronidation (GO:0052695)4.44501109
14L-fucose catabolic process (GO:0042355)4.43791215
15fucose catabolic process (GO:0019317)4.43791215
16L-fucose metabolic process (GO:0042354)4.43791215
17positive regulation of guanylate cyclase activity (GO:0031284)4.40869163
18antigen processing and presentation via MHC class Ib (GO:0002475)4.33811326
19Arp2/3 complex-mediated actin nucleation (GO:0034314)4.27481113
20intestinal epithelial cell development (GO:0060576)4.22663051
21flavonoid metabolic process (GO:0009812)4.17646394
22calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.16404623
23regulation of bile acid biosynthetic process (GO:0070857)4.06039354
24positive regulation of B cell differentiation (GO:0045579)3.99969816
25angiotensin maturation (GO:0002003)3.95955016
26regulation of interferon-beta biosynthetic process (GO:0045357)3.95111595
27kidney morphogenesis (GO:0060993)3.92009153
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.85170967
29regulation of gamma-delta T cell differentiation (GO:0045586)3.84254128
30immunoglobulin mediated immune response (GO:0016064)3.82044496
31homocysteine metabolic process (GO:0050667)3.79987127
32positive regulation by symbiont of host defense response (GO:0052509)3.72553234
33modulation by symbiont of host defense response (GO:0052031)3.72553234
34modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.72553234
35modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.72553234
36positive regulation by organism of defense response of other organism involved in symbiotic interact3.72553234
37modulation by symbiont of host immune response (GO:0052553)3.72553234
38hepatocyte apoptotic process (GO:0097284)3.72361762
39O-glycan processing (GO:0016266)3.72350280
40arginine metabolic process (GO:0006525)3.69824128
41fucosylation (GO:0036065)3.69633925
42actin nucleation (GO:0045010)3.68853141
43regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.68416268
44regulation of gamma-delta T cell activation (GO:0046643)3.64780628
45epoxygenase P450 pathway (GO:0019373)3.63125259
46drug catabolic process (GO:0042737)3.61563997
47exogenous drug catabolic process (GO:0042738)3.59010496
48gap junction assembly (GO:0016264)3.58322723
49regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.56819484
50primary alcohol catabolic process (GO:0034310)3.51350867
51very-low-density lipoprotein particle assembly (GO:0034379)3.44474166
52JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.44276526
53response to type I interferon (GO:0034340)3.41151612
54regulation of B cell receptor signaling pathway (GO:0050855)3.41103565
55regulation of B cell differentiation (GO:0045577)3.40533391
56positive regulation of interferon-alpha production (GO:0032727)3.40184268
57drug metabolic process (GO:0017144)3.40121410
58regulation of interleukin-12 biosynthetic process (GO:0045075)3.37663659
59tolerance induction (GO:0002507)3.36390392
60type I interferon signaling pathway (GO:0060337)3.35748486
61cellular response to type I interferon (GO:0071357)3.35748486
62respiratory burst (GO:0045730)3.34068958
63bile acid and bile salt transport (GO:0015721)3.32425289
64plasma lipoprotein particle assembly (GO:0034377)3.32334350
65L-ascorbic acid metabolic process (GO:0019852)3.32184727
66sulfate transmembrane transport (GO:1902358)3.29709065
67sulfur compound transport (GO:0072348)3.29286451
68B cell receptor signaling pathway (GO:0050853)3.28990502
69regulation of interferon-alpha production (GO:0032647)3.27433479
70ethanol metabolic process (GO:0006067)3.22669870
71vitamin transport (GO:0051180)3.20751010
72positive regulation of respiratory burst (GO:0060267)3.19126275
73interferon-gamma-mediated signaling pathway (GO:0060333)3.18730791
74regulation of posttranscriptional gene silencing (GO:0060147)3.18697645
75regulation of gene silencing by miRNA (GO:0060964)3.18697645
76regulation of gene silencing by RNA (GO:0060966)3.18697645
77sphingomyelin metabolic process (GO:0006684)3.17621961
78ethanol oxidation (GO:0006069)3.16789715
79T cell migration (GO:0072678)3.15387341
80transcytosis (GO:0045056)3.14824826
81negative regulation of keratinocyte proliferation (GO:0010839)3.14428633
82myeloid dendritic cell activation (GO:0001773)3.13762661
83negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.12074449
84negative regulation of cell killing (GO:0031342)3.12074449
85phosphatidylserine acyl-chain remodeling (GO:0036150)3.11505928
86leukocyte aggregation (GO:0070486)3.09481903
87vitamin A metabolic process (GO:0006776)3.09271011
88sulfate transport (GO:0008272)3.08929926
89response to interleukin-15 (GO:0070672)3.08306922
90high-density lipoprotein particle remodeling (GO:0034375)3.07135993
91phospholipid efflux (GO:0033700)3.06788310
92pyrimidine-containing compound transmembrane transport (GO:0072531)3.05177812
93cellular extravasation (GO:0045123)3.03867707
94mast cell activation (GO:0045576)3.02817563
95neutrophil activation involved in immune response (GO:0002283)3.02060550
96antibacterial humoral response (GO:0019731)3.01984604
97hormone catabolic process (GO:0042447)3.01350535
98heme transport (GO:0015886)3.00281768
99UDP-N-acetylglucosamine metabolic process (GO:0006047)2.99947438
100negative regulation of T cell differentiation in thymus (GO:0033085)2.99512616
101myeloid dendritic cell differentiation (GO:0043011)2.99502242
102response to protozoan (GO:0001562)2.99230694
103tight junction assembly (GO:0070830)2.97249652
104regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.97238566
105auditory receptor cell differentiation (GO:0042491)2.97042980
106interferon-gamma production (GO:0032609)2.96836756
107production of molecular mediator involved in inflammatory response (GO:0002532)2.96737777
108regulation of cGMP biosynthetic process (GO:0030826)2.96267641
109negative regulation of phagocytosis (GO:0050765)2.95888464
110natural killer cell differentiation (GO:0001779)2.95730528
111regulation of keratinocyte proliferation (GO:0010837)2.94584173
112establishment of apical/basal cell polarity (GO:0035089)2.94461035
113bile acid metabolic process (GO:0008206)2.94207105
114fat-soluble vitamin biosynthetic process (GO:0042362)2.94120080
115mature B cell differentiation (GO:0002335)2.93687335
116protein autoprocessing (GO:0016540)2.93257003
117regulation of triglyceride catabolic process (GO:0010896)2.92121157
118transepithelial transport (GO:0070633)2.90961261
119regulation of T cell tolerance induction (GO:0002664)2.90293338
120axonemal dynein complex assembly (GO:0070286)2.89841883
121sulfation (GO:0051923)2.89504015
122B cell mediated immunity (GO:0019724)2.88742553
123glutathione biosynthetic process (GO:0006750)2.87436326
124positive regulation of glycoprotein biosynthetic process (GO:0010560)2.86780234
125macrophage activation involved in immune response (GO:0002281)2.86690176
126maintenance of gastrointestinal epithelium (GO:0030277)2.86422914
127defense response to protozoan (GO:0042832)2.85057623
128arginine catabolic process (GO:0006527)2.84142354
129T cell homeostasis (GO:0043029)2.83977095
130regulation of T cell receptor signaling pathway (GO:0050856)2.83831353
131drug transmembrane transport (GO:0006855)2.83737873
132antimicrobial humoral response (GO:0019730)2.83092779
133mucosal-associated lymphoid tissue development (GO:0048537)2.82793298
134Peyers patch development (GO:0048541)2.82793298
135myeloid cell activation involved in immune response (GO:0002275)2.81961659
136positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.81367743
137mature B cell differentiation involved in immune response (GO:0002313)2.81109078
138diterpenoid biosynthetic process (GO:0016102)2.80400376
139neutrophil activation (GO:0042119)2.79622995
140digestion (GO:0007586)2.79506440
141lipopolysaccharide-mediated signaling pathway (GO:0031663)2.79446206
142positive regulation of antigen processing and presentation (GO:0002579)2.79223391
143lipoprotein transport (GO:0042953)2.79024202
144alkaloid metabolic process (GO:0009820)2.78553706
145leukocyte cell-cell adhesion (GO:0007159)2.77375439
1463-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.77013028
147purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.77013028
148nonribosomal peptide biosynthetic process (GO:0019184)2.75727459
149granulocyte activation (GO:0036230)2.75695756
150drug transport (GO:0015893)2.75389002
151regulation of systemic arterial blood pressure (GO:0003073)2.75201925
152B cell homeostasis (GO:0001782)2.74569942
153response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.74378942
154response to host immune response (GO:0052572)2.74378942
155nucleotide-sugar biosynthetic process (GO:0009226)2.72765396
156positive regulation of macrophage differentiation (GO:0045651)2.71716979
157urate metabolic process (GO:0046415)2.69873679
158regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.69303233
159endocrine process (GO:0050886)2.69303233
160regulation of systemic arterial blood pressure by hormone (GO:0001990)2.69303233
161positive regulation of natural killer cell differentiation (GO:0032825)2.69062919
162response to peptidoglycan (GO:0032494)2.68857882
163NADH metabolic process (GO:0006734)2.68588072
164digestive system process (GO:0022600)2.68013022
165natural killer cell activation (GO:0030101)2.66921974
166polarized epithelial cell differentiation (GO:0030859)2.66152062
167signal transduction involved in regulation of gene expression (GO:0023019)2.66117725
168excretion (GO:0007588)2.65638982
169phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.65532574
170thyroid hormone metabolic process (GO:0042403)2.65134988
171cellular response to interferon-beta (GO:0035458)2.64277128
172regulation of type I interferon-mediated signaling pathway (GO:0060338)2.64156415
173primary alcohol metabolic process (GO:0034308)2.63479262
174multicellular organismal water homeostasis (GO:0050891)2.62993654
175negative thymic T cell selection (GO:0045060)2.62390566
176negative regulation of epidermal cell differentiation (GO:0045605)2.62280994
177negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.61597698
178fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.61187714
179vitamin biosynthetic process (GO:0009110)2.60806458
180response to interferon-beta (GO:0035456)2.59640510
181response to fungus (GO:0009620)2.58197877
182response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.58149310
183response to host (GO:0075136)2.58149310
184response to host defenses (GO:0052200)2.58149310
185actin filament polymerization (GO:0030041)2.56909330
186dendritic cell migration (GO:0036336)2.56083189
187lymphocyte homeostasis (GO:0002260)2.54298712
188positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.53932513
189growth hormone receptor signaling pathway (GO:0060396)2.53365258
190dendritic cell chemotaxis (GO:0002407)2.53316095
191positive regulation of histone deacetylation (GO:0031065)2.53064766
192negative regulation of T cell receptor signaling pathway (GO:0050860)2.51946191
193negative T cell selection (GO:0043383)2.51751104
194activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.51464217
195negative regulation of B cell proliferation (GO:0030889)2.51309035
196positive regulation of interferon-beta production (GO:0032728)2.51086706
197positive regulation of lamellipodium assembly (GO:0010592)2.50942623
198NIK/NF-kappaB signaling (GO:0038061)2.49080023
199response to muramyl dipeptide (GO:0032495)2.48828251

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.92279979
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.10189280
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.82116469
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.50337399
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.46770998
6E2F7_22180533_ChIP-Seq_HELA_Human3.44309738
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.40978195
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.39802806
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.27959346
10MYB_21317192_ChIP-Seq_ERMYB_Mouse3.09946584
11IRF8_27001747_Chip-Seq_BMDM_Mouse3.09085070
12* HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.05339731
13BP1_19119308_ChIP-ChIP_Hs578T_Human3.03344682
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.89647105
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.89125239
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.86415236
17EGR1_23403033_ChIP-Seq_LIVER_Mouse2.75219963
18FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.73325552
19MYC_22102868_ChIP-Seq_BL_Human2.70898092
20VDR_21846776_ChIP-Seq_THP-1_Human2.69899722
21SCL_19346495_ChIP-Seq_HPC-7_Human2.68847489
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.65155689
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.63903768
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.59732260
25CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.58053668
26MYB_26560356_Chip-Seq_TH2_Human2.56963305
27ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.52592998
28VDR_22108803_ChIP-Seq_LS180_Human2.52336762
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.50014888
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.42958099
31MAF_26560356_Chip-Seq_TH1_Human2.40421682
32VDR_24763502_ChIP-Seq_THP-1_Human2.38045146
33* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.30868154
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.29595070
35* AR_21915096_ChIP-Seq_LNCaP-1F5_Human2.29315780
36BRD4_27068464_Chip-Seq_AML-cells_Mouse2.24910447
37RUNX_20019798_ChIP-Seq_JUKART_Human2.23610531
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.21550397
39RUNX1_22412390_ChIP-Seq_EML_Mouse2.21252208
40SPI1_23547873_ChIP-Seq_NB4_Human2.19300722
41KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.17130030
42KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.17130030
43KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.17130030
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.15773631
45ZNF274_21170338_ChIP-Seq_K562_Hela2.14595626
46MYB_26560356_Chip-Seq_TH1_Human2.13786663
47* SOX2_20726797_ChIP-Seq_SW620_Human2.12726625
48TCF7_22412390_ChIP-Seq_EML_Mouse2.06018346
49* ESR1_21235772_ChIP-Seq_MCF-7_Human2.03672584
50FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human2.02537251
51* RXR_22158963_ChIP-Seq_LIVER_Mouse2.00595321
52UTX_26944678_Chip-Seq_JUKART_Human1.99661281
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.96086723
54SPI1_23127762_ChIP-Seq_K562_Human1.94153918
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.93220259
56AR_21909140_ChIP-Seq_LNCAP_Human1.92184007
57LXR_22158963_ChIP-Seq_LIVER_Mouse1.89308517
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.87703964
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.85118886
60* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.85063730
61E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.83543716
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83281244
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.78087325
64FOXA1_25552417_ChIP-Seq_VCAP_Human1.73409157
65GATA3_24758297_ChIP-Seq_MCF-7_Human1.70900427
66TP63_17297297_ChIP-ChIP_HaCaT_Human1.63322227
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58315029
68* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.57775221
69GATA2_22383799_ChIP-Seq_G1ME_Mouse1.57543159
70LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.55161889
71BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.54619155
72CDX2_22108803_ChIP-Seq_LS180_Human1.51064784
73* HNF4A_19822575_ChIP-Seq_HepG2_Human1.50464974
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.50354946
75GATA3_27048872_Chip-Seq_THYMUS_Human1.50332291
76CDX2_20551321_ChIP-Seq_CACO-2_Human1.50208612
77PU_27001747_Chip-Seq_BMDM_Mouse1.50063857
78* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48564206
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47181108
80FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.46587513
81NANOG_20526341_ChIP-Seq_ESCs_Human1.45869822
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.45299220
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.45299220
84CEBPB_22108803_ChIP-Seq_LS180_Human1.44814699
85P63_26484246_Chip-Seq_KERATINOCYTES_Human1.44800151
86MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.44713645
87MAF_26560356_Chip-Seq_TH2_Human1.44174286
88FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.43342138
89* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42633783
90GATA1_22383799_ChIP-Seq_G1ME_Mouse1.41408673
91* KDM2B_26808549_Chip-Seq_DND41_Human1.40317666
92NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.39265832
93KLF5_25053715_ChIP-Seq_YYC3_Human1.38969392
94TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36992575
95AR_20517297_ChIP-Seq_VCAP_Human1.36546261
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35564844
97GATA1_22025678_ChIP-Seq_K562_Human1.34553739
98* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30717695
99ELK3_25401928_ChIP-Seq_HUVEC_Human1.28006361
100MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26798873
101HOXB7_26014856_ChIP-Seq_BT474_Human1.26441407
102GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26225261
103CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26182315
104KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25389033
105VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24239720
106LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22871565
107* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.22663545
108GATA1_19941827_ChIP-Seq_MEL_Mouse1.22366364
109P53_21459846_ChIP-Seq_SAOS-2_Human1.21981861
110TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21504659
111ELF5_23300383_ChIP-Seq_T47D_Human1.21339598
112ESR2_21235772_ChIP-Seq_MCF-7_Human1.21039041
113CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.19988560
114NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.19718080
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18659529
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17763788
117GATA3_21878914_ChIP-Seq_MCF-7_Human1.17652657
118SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16046251
119SALL1_21062744_ChIP-ChIP_HESCs_Human1.14506348
120* GATA6_25053715_ChIP-Seq_YYC3_Human1.13235515
121VDR_24787735_ChIP-Seq_THP-1_Human1.12979534
122* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12934585
123* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11903094
124SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10906439
125NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.10764283
126TCF4_18268006_ChIP-ChIP_LS174T_Human1.10503624
127TCF4_22108803_ChIP-Seq_LS180_Human1.09812728
128KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.08841966
129PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08442719
130TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08372459
131* GATA2_19941826_ChIP-Seq_K562_Human1.07341830
132GATA3_26560356_Chip-Seq_TH2_Human1.06149783
133NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05078349
134TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03980947
135ERA_21632823_ChIP-Seq_H3396_Human1.03516534
136FOXH1_21741376_ChIP-Seq_ESCs_Human1.02859692
137FOXA2_19822575_ChIP-Seq_HepG2_Human1.02607626
138CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02016265
139PHF8_20622854_ChIP-Seq_HELA_Human1.01975961
140P300_27268052_Chip-Seq_Bcells_Human1.01387686
141GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01089704
142FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00601194
143E2F1_20622854_ChIP-Seq_HELA_Human1.00540772
144RBPJ_21746931_ChIP-Seq_IB4_Human0.99253488
145IRF1_19129219_ChIP-ChIP_H3396_Human0.99080742
146* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.98768816
147* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94988287
148LXR_22292898_ChIP-Seq_THP-1_Human0.94954589
149GATA2_21666600_ChIP-Seq_HMVEC_Human0.94849947
150PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93638654
151PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93361957
152* OCT4_20526341_ChIP-Seq_ESCs_Human0.92884396
153EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92731676
154ETV1_20927104_ChIP-Seq_GIST48_Human0.92674801
155PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.92661533
156BCAT_22108803_ChIP-Seq_LS180_Human0.92628290
157* NCOR1_26117541_ChIP-Seq_K562_Human0.92474228
158NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92293935
159* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92087749
160BCOR_27268052_Chip-Seq_Bcells_Human0.91854471
161P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.91327081
162SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90296350
163ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89813630
164NCOR_22424771_ChIP-Seq_293T_Human0.89706322
165FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.87989832
166YY1_22570637_ChIP-Seq_MALME-3M_Human0.87712016
167* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86974754
168PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86658054
169* GATA4_25053715_ChIP-Seq_YYC3_Human0.86420120
170SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.86072162
171PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85956287
172* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85882807
173KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.85440219
174RACK7_27058665_Chip-Seq_MCF-7_Human0.84897627
175EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.84456379
176GATA1_19941826_ChIP-Seq_K562_Human0.84330497
177ETS1_22383799_ChIP-Seq_G1ME_Mouse0.84257209
178* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84172818
179AHR_22903824_ChIP-Seq_MCF-7_Human0.83970425
180TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83437462
181FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81570811
182GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80278242
183RUNX1_27514584_Chip-Seq_MCF-7_Human0.78105408
184GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77728640
185SRY_22984422_ChIP-ChIP_TESTIS_Rat0.77456459
186GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77374583
187ERG_20887958_ChIP-Seq_HPC-7_Mouse0.77237146
188ZNF263_19887448_ChIP-Seq_K562_Human0.76894987

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.89072338
2MP0005085_abnormal_gallbladder_physiolo3.78267259
3MP0003300_gastrointestinal_ulcer3.29501770
4MP0003303_peritoneal_inflammation3.28563942
5MP0004019_abnormal_vitamin_homeostasis3.23434827
6MP0005365_abnormal_bile_salt3.12565238
7MP0001873_stomach_inflammation2.98349787
8MP0003436_decreased_susceptibility_to2.90252913
9MP0003866_abnormal_defecation2.86370219
10MP0005671_abnormal_response_to2.84421361
11MP0009785_altered_susceptibility_to2.82860431
12MP0000566_synostosis2.79425645
13MP0002139_abnormal_hepatobiliary_system2.73352040
14MP0001800_abnormal_humoral_immune2.70809993
15MP0003941_abnormal_skin_development2.65044914
16MP0010234_abnormal_vibrissa_follicle2.59879670
17MP0005025_abnormal_response_to2.59260047
18MP0000685_abnormal_immune_system2.58202672
19MP0001790_abnormal_immune_system2.56254218
20MP0005387_immune_system_phenotype2.56254218
21MP0010155_abnormal_intestine_physiology2.56044620
22MP0002452_abnormal_antigen_presenting2.55988677
23MP0005000_abnormal_immune_tolerance2.55821722
24MP0002148_abnormal_hypersensitivity_rea2.53996813
25MP0008875_abnormal_xenobiotic_pharmacok2.42120226
26MP0001819_abnormal_immune_cell2.39254326
27MP0002723_abnormal_immune_serum2.38252175
28MP0002420_abnormal_adaptive_immunity2.37733156
29MP0002419_abnormal_innate_immunity2.33859493
30MP0005464_abnormal_platelet_physiology2.28014796
31MP0003718_maternal_effect2.24021950
32MP0004043_abnormal_pH_regulation2.22380420
33MP0003183_abnormal_peptide_metabolism2.21078260
34MP0002396_abnormal_hematopoietic_system2.18301852
35MP0000490_abnormal_crypts_of2.17212907
36MP0004947_skin_inflammation2.14596530
37MP0006082_CNS_inflammation2.14193697
38MP0002796_impaired_skin_barrier2.13408439
39MP0002166_altered_tumor_susceptibility2.09710736
40MP0005310_abnormal_salivary_gland2.09532641
41MP0002398_abnormal_bone_marrow2.08051707
42MP0010352_gastrointestinal_tract_polyps1.99042342
43MP0003763_abnormal_thymus_physiology1.93952418
44MP0000716_abnormal_immune_system1.91516480
45MP0002098_abnormal_vibrissa_morphology1.90870537
46MP0004782_abnormal_surfactant_physiolog1.88359751
47MP0002006_tumorigenesis1.83442103
48MP0002405_respiratory_system_inflammati1.82467450
49MP0001845_abnormal_inflammatory_respons1.78413816
50MP0009333_abnormal_splenocyte_physiolog1.77446651
51MP0001881_abnormal_mammary_gland1.77279645
52MP0003890_abnormal_embryonic-extraembry1.76760697
53MP0009379_abnormal_foot_pigmentation1.75819737
54MP0002254_reproductive_system_inflammat1.75017291
55MP0010329_abnormal_lipoprotein_level1.72070607
56MP0000465_gastrointestinal_hemorrhage1.71171894
57MP0002876_abnormal_thyroid_physiology1.70639482
58MP0004808_abnormal_hematopoietic_stem1.68182724
59MP0003806_abnormal_nucleotide_metabolis1.66953129
60MP0001663_abnormal_digestive_system1.66789755
61MP0005332_abnormal_amino_acid1.65889931
62MP0005174_abnormal_tail_pigmentation1.64594357
63MP0010678_abnormal_skin_adnexa1.64118566
64MP0000689_abnormal_spleen_morphology1.62975242
65MP0002722_abnormal_immune_system1.62062893
66MP0001545_abnormal_hematopoietic_system1.61904147
67MP0005397_hematopoietic_system_phenotyp1.61904147
68MP0003195_calcinosis1.60628223
69MP0002429_abnormal_blood_cell1.60343166
70MP0008872_abnormal_physiological_respon1.59751208
71MP0009278_abnormal_bone_marrow1.58332829
72MP0005636_abnormal_mineral_homeostasis1.56941218
73MP0004264_abnormal_extraembryonic_tissu1.55681562
74MP0001764_abnormal_homeostasis1.55564850
75MP0004510_myositis1.46476512
76MP0000537_abnormal_urethra_morphology1.45815766
77MP0001853_heart_inflammation1.45347940
78MP0005377_hearing/vestibular/ear_phenot1.44310360
79MP0003878_abnormal_ear_physiology1.44310360
80MP0000383_abnormal_hair_follicle1.43862500
81MP0003724_increased_susceptibility_to1.43198169
82MP0001533_abnormal_skeleton_physiology1.39002262
83MP0009643_abnormal_urine_homeostasis1.38649126
84MP0000678_abnormal_parathyroid_gland1.37078292
85MP0004957_abnormal_blastocyst_morpholog1.35941401
86MP0010307_abnormal_tumor_latency1.33764760
87MP0001485_abnormal_pinna_reflex1.30311595
88MP0005058_abnormal_lysosome_morphology1.29250158
89MP0003315_abnormal_perineum_morphology1.28514922
90MP0003448_altered_tumor_morphology1.27725922
91MP0001666_abnormal_nutrient_absorption1.26638643
92MP0008469_abnormal_protein_level1.26613390
93MP0008877_abnormal_DNA_methylation1.25775201
94MP0000858_altered_metastatic_potential1.23045602
95MP0000427_abnormal_hair_cycle1.19256318
96MP0005381_digestive/alimentary_phenotyp1.18449035
97MP0000579_abnormal_nail_morphology1.17130911
98MP0003119_abnormal_digestive_system1.16526451
99MP0005501_abnormal_skin_physiology1.16260424
100MP0000703_abnormal_thymus_morphology1.16048753
101MP0000538_abnormal_urinary_bladder1.15117363
102MP0001188_hyperpigmentation1.09029678
103MP0000477_abnormal_intestine_morphology1.06968283
104MP0005166_decreased_susceptibility_to1.06844498
105MP0005083_abnormal_biliary_tract1.02990982
106MP0003567_abnormal_fetal_cardiomyocyte1.02938857
107MP0003283_abnormal_digestive_organ1.00158160
108MP0005076_abnormal_cell_differentiation0.98793036
109MP0009764_decreased_sensitivity_to0.97837466
110MP0000569_abnormal_digit_pigmentation0.97464971
111MP0000467_abnormal_esophagus_morphology0.97406521
112MP0003172_abnormal_lysosome_physiology0.95053006
113MP0003045_fibrosis0.94471817
114MP0009840_abnormal_foam_cell0.93103409
115MP0002277_abnormal_respiratory_mucosa0.93022681
116MP0000377_abnormal_hair_follicle0.85212715
117MP0003638_abnormal_response/metabolism_0.84963104
118MP0005395_other_phenotype0.84832138
119MP0003693_abnormal_embryo_hatching0.84668681
120MP0002019_abnormal_tumor_incidence0.84586089
121MP0003075_altered_response_to0.84186614
122MP0004147_increased_porphyrin_level0.82632437
123MP0004133_heterotaxia0.81035037
124MP0002118_abnormal_lipid_homeostasis0.80875673
125MP0000470_abnormal_stomach_morphology0.80821520
126MP0003191_abnormal_cellular_cholesterol0.79360001
127MP0005319_abnormal_enzyme/_coenzyme0.78128729
128MP0001851_eye_inflammation0.78102901
129MP0006054_spinal_hemorrhage0.77346858
130MP0002138_abnormal_hepatobiliary_system0.77130982
131MP0002998_abnormal_bone_remodeling0.75755525
132MP0001919_abnormal_reproductive_system0.74985627
133MP0000015_abnormal_ear_pigmentation0.74894582
134MP0002009_preneoplasia0.74807904
135MP0005360_urolithiasis0.74489772
136MP0002111_abnormal_tail_morphology0.71707929
137MP0001756_abnormal_urination0.71634416
138MP0002136_abnormal_kidney_physiology0.70475732
139MP0003252_abnormal_bile_duct0.69076405
140MP0008873_increased_physiological_sensi0.68571244
141MP0000627_abnormal_mammary_gland0.68555337
142MP0001501_abnormal_sleep_pattern0.68425100
143MP0000343_altered_response_to0.67426130
144MP0001664_abnormal_digestion0.66660917
145MP0001765_abnormal_ion_homeostasis0.66407348
146MP0000516_abnormal_urinary_system0.64883300
147MP0005367_renal/urinary_system_phenotyp0.64883300
148MP0000604_amyloidosis0.64704303
149MP0002933_joint_inflammation0.63918552
150MP0003868_abnormal_feces_composition0.63121613
151MP0008961_abnormal_basal_metabolism0.62897885
152MP0003566_abnormal_cell_adhesion0.62011677
153MP0002132_abnormal_respiratory_system0.61718650
154MP0003656_abnormal_erythrocyte_physiolo0.59661649
155MP0003453_abnormal_keratinocyte_physiol0.59126512
156MP0005410_abnormal_fertilization0.59068748
157MP0003953_abnormal_hormone_level0.57613414
158MP0003011_delayed_dark_adaptation0.57466190
159MP0001216_abnormal_epidermal_layer0.56029216
160MP0000249_abnormal_blood_vessel0.55222748
161MP0005670_abnormal_white_adipose0.55153985
162MP0009931_abnormal_skin_appearance0.54959296
163MP0005389_reproductive_system_phenotype0.54717602
164MP0000647_abnormal_sebaceous_gland0.54641178
165MP0002909_abnormal_adrenal_gland0.54629116
166MP0005075_abnormal_melanosome_morpholog0.54628708
167MP0005448_abnormal_energy_balance0.53549098
168MP0009763_increased_sensitivity_to0.51057142
169MP0009765_abnormal_xenobiotic_induced0.51023954
170MP0009115_abnormal_fat_cell0.50188525
171MP0000609_abnormal_liver_physiology0.49086934

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.83928956
2Recurrent abscess formation (HP:0002722)4.74964000
3Abnormality of glutamine family amino acid metabolism (HP:0010902)4.63281797
4Chronic otitis media (HP:0000389)4.46548021
5Recurrent bacterial skin infections (HP:0005406)4.37824755
6Myositis (HP:0100614)4.36267796
7Hyperactive renin-angiotensin system (HP:0000841)4.30091201
8Recurrent viral infections (HP:0004429)4.26913832
9Recurrent fungal infections (HP:0002841)4.18508944
10Decreased circulating renin level (HP:0003351)4.06127550
11Chronic bronchitis (HP:0004469)4.04274699
12Nasal polyposis (HP:0100582)3.99463617
13Elevated erythrocyte sedimentation rate (HP:0003565)3.94661842
14Autoimmune thrombocytopenia (HP:0001973)3.91485757
15Cellulitis (HP:0100658)3.91198831
16IgM deficiency (HP:0002850)3.90484115
17Hyperglycinuria (HP:0003108)3.79900932
18Recurrent bronchitis (HP:0002837)3.70372461
19Inflammation of the large intestine (HP:0002037)3.60842546
20Thrombocytosis (HP:0001894)3.54848174
21Gastrointestinal inflammation (HP:0004386)3.54207302
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.52776497
23Petechiae (HP:0000967)3.48834571
24Colitis (HP:0002583)3.44811684
25Abnormality of renin-angiotensin system (HP:0000847)3.43167117
26Abnormality of the nasal mucosa (HP:0000433)3.42724247
27Abnormality of macrophages (HP:0004311)3.40845694
28Orchitis (HP:0100796)3.40332746
29Interstitial pulmonary disease (HP:0006530)3.36737485
30Malnutrition (HP:0004395)3.36028832
31Agammaglobulinemia (HP:0004432)3.35035781
32Meningitis (HP:0001287)3.33677966
33Vacuolated lymphocytes (HP:0001922)3.27142377
34Vasculitis (HP:0002633)3.23292251
35Hypobetalipoproteinemia (HP:0003563)3.22744720
36Pustule (HP:0200039)3.22271191
37Retrobulbar optic neuritis (HP:0100654)3.22033541
38Optic neuritis (HP:0100653)3.22033541
39Right ventricular cardiomyopathy (HP:0011663)3.20391696
40Abnormality of glycine metabolism (HP:0010895)3.19345056
41Abnormality of serine family amino acid metabolism (HP:0010894)3.19345056
42Increased IgE level (HP:0003212)3.13764272
43Hydroxyprolinuria (HP:0003080)3.13360990
44Abnormality of proline metabolism (HP:0010907)3.13360990
45Abnormality of T cell physiology (HP:0011840)3.13069264
46Abnormality of the vitamin B12 metabolism (HP:0004341)3.07496160
47Mediastinal lymphadenopathy (HP:0100721)3.04694693
48Abnormality of vitamin B metabolism (HP:0004340)2.99719181
49Recurrent skin infections (HP:0001581)2.98522360
50Recurrent cutaneous fungal infections (HP:0011370)2.96586346
51Chronic mucocutaneous candidiasis (HP:0002728)2.96586346
52Autoimmune hemolytic anemia (HP:0001890)2.89895957
53Chronic diarrhea (HP:0002028)2.88777458
54Abnormality of T cells (HP:0002843)2.88092723
55Chronic obstructive pulmonary disease (HP:0006510)2.84325445
56Obstructive lung disease (HP:0006536)2.84325445
57Osteomyelitis (HP:0002754)2.79962694
58Recurrent gram-negative bacterial infections (HP:0005420)2.78688035
59Intrahepatic cholestasis (HP:0001406)2.78522907
60Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.77812247
61Pili torti (HP:0003777)2.74394925
62Thyroiditis (HP:0100646)2.70207979
63Abnormality of monocarboxylic acid metabolism (HP:0010996)2.69000661
64Abnormal hair laboratory examination (HP:0003328)2.67791985
65Abnormality of vitamin metabolism (HP:0100508)2.65692605
66Arterial thrombosis (HP:0004420)2.65206851
67Panhypogammaglobulinemia (HP:0003139)2.62232986
68Alkalosis (HP:0001948)2.61634276
69Impaired platelet aggregation (HP:0003540)2.61241982
70Abnormal platelet function (HP:0011869)2.61241982
71Gingivitis (HP:0000230)2.56602598
72T lymphocytopenia (HP:0005403)2.55497266
73Lymphopenia (HP:0001888)2.55097172
74Prolonged bleeding time (HP:0003010)2.52651498
75Fat malabsorption (HP:0002630)2.52424853
76Fatigue (HP:0012378)2.51828434
77Ileus (HP:0002595)2.51407610
78Acanthocytosis (HP:0001927)2.51268074
79Abnormality of cells of the lymphoid lineage (HP:0012140)2.49376794
80Papilloma (HP:0012740)2.49244454
81Verrucae (HP:0200043)2.49244454
82Abnormality of T cell number (HP:0011839)2.48607112
83Encephalitis (HP:0002383)2.48257901
84Periodontitis (HP:0000704)2.44386244
85Abnormal platelet volume (HP:0011876)2.43000652
86Pigmentary retinal degeneration (HP:0001146)2.42579425
87Chronic sinusitis (HP:0011109)2.41902925
88Abnormality of B cell number (HP:0010975)2.40967207
89B lymphocytopenia (HP:0010976)2.40967207
90Abnormality of chloride homeostasis (HP:0011422)2.40675730
91Spontaneous hematomas (HP:0007420)2.40410723
92Abnormality of aspartate family amino acid metabolism (HP:0010899)2.39005263
93IgA deficiency (HP:0002720)2.37458941
94Metabolic alkalosis (HP:0200114)2.37169257
95Abnormality of the fingertips (HP:0001211)2.34446422
96Chest pain (HP:0100749)2.33472966
97Sepsis (HP:0100806)2.33363041
98Rhinitis (HP:0012384)2.33216313
99Hyperaldosteronism (HP:0000859)2.32590934
100Gastrointestinal stroma tumor (HP:0100723)2.32038482
101Abnormal biliary tract morphology (HP:0012440)2.30728358
102Disinhibition (HP:0000734)2.30054142
103Hypoplasia of the uterus (HP:0000013)2.29388547
104Widely patent fontanelles and sutures (HP:0004492)2.27176343
105Amelogenesis imperfecta (HP:0000705)2.26893782
106Woolly hair (HP:0002224)2.26541146
107Confusion (HP:0001289)2.26487270
108Bronchitis (HP:0012387)2.24989103
109Bronchiectasis (HP:0002110)2.24459009
110Increased cerebral lipofuscin (HP:0011813)2.24233994
111Abnormal respiratory epithelium morphology (HP:0012253)2.18672203
112Abnormal respiratory motile cilium morphology (HP:0005938)2.18672203
113Breast hypoplasia (HP:0003187)2.18489137
114Hypergammaglobulinemia (HP:0010702)2.17204825
115Keratoconjunctivitis sicca (HP:0001097)2.16949776
116Pulmonary infiltrates (HP:0002113)2.15146233
117Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.14690435
118Plantar hyperkeratosis (HP:0007556)2.14484658
119Abnormality of urine glucose concentration (HP:0011016)2.13756374
120Glycosuria (HP:0003076)2.13756374
121Villous atrophy (HP:0011473)2.12444763
122Abnormality of small intestinal villus morphology (HP:0011472)2.12444763
123Abnormal respiratory motile cilium physiology (HP:0012261)2.11845909
124Abnormality of serum amino acid levels (HP:0003112)2.11619799
125Hemoptysis (HP:0002105)2.11529038
126Birth length less than 3rd percentile (HP:0003561)2.11512678
127Biliary tract neoplasm (HP:0100574)2.11225707
128Recurrent sinusitis (HP:0011108)2.10403294
129Skin ulcer (HP:0200042)2.10306419
130Stomach cancer (HP:0012126)2.10242236
131Stomatitis (HP:0010280)2.09948403
132Cheilitis (HP:0100825)2.09634830
133Abnormality of the prostate (HP:0008775)2.09601297
134Leukocytosis (HP:0001974)2.09320957
135Dynein arm defect of respiratory motile cilia (HP:0012255)2.09083229
136Absent/shortened dynein arms (HP:0200106)2.09083229
137Hematochezia (HP:0002573)2.08283616
138Abnormality of sulfur amino acid metabolism (HP:0004339)2.07862121
139Prostate neoplasm (HP:0100787)2.07381169
140Abnormality of pyrimidine metabolism (HP:0004353)2.02163176
141Hyperglycinemia (HP:0002154)2.02109416
142Fragile nails (HP:0001808)2.00967097
143Gingival bleeding (HP:0000225)2.00721153
144Increased mean platelet volume (HP:0011877)1.96722152
145Papilledema (HP:0001085)1.95990944
146Eosinophilia (HP:0001880)1.95476242
147Hyperammonemia (HP:0001987)1.94914267
148Increased density of long bones (HP:0006392)1.94909936
149Urticaria (HP:0001025)1.94272256
150True hermaphroditism (HP:0010459)1.93963882
151Severe combined immunodeficiency (HP:0004430)1.91850766
152Megaloblastic anemia (HP:0001889)1.91167082
153Gonadal dysgenesis (HP:0000133)1.91164265
154Keratoconjunctivitis (HP:0001096)1.90834579
155Palmoplantar hyperkeratosis (HP:0000972)1.90525530
156Abnormality of eosinophils (HP:0001879)1.90346804
157Epistaxis (HP:0000421)1.90308369
158Viral hepatitis (HP:0006562)1.90298477
159Combined immunodeficiency (HP:0005387)1.89111757
160Curly hair (HP:0002212)1.88984994
161Increased neuronal autofluorescent lipopigment (HP:0002074)1.88591093
162Alopecia of scalp (HP:0002293)1.87169471
163Hypoplastic labia majora (HP:0000059)1.86884370
164Osteomalacia (HP:0002749)1.86460494
165Proximal tubulopathy (HP:0000114)1.81873662
166Flat acetabular roof (HP:0003180)1.81817642
167Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.81469926
168Epidermoid cyst (HP:0200040)1.79693935
169Palmar hyperkeratosis (HP:0010765)1.79536762
170Genu varum (HP:0002970)1.79211884
171Abnormal ciliary motility (HP:0012262)1.78185909
172Abnormality of homocysteine metabolism (HP:0010919)1.76599340
173Homocystinuria (HP:0002156)1.76599340
174Pendular nystagmus (HP:0012043)1.75921457
175Conjugated hyperbilirubinemia (HP:0002908)1.74936286
176Pancreatic cysts (HP:0001737)1.74928595
177Focal segmental glomerulosclerosis (HP:0000097)1.74040435
178Abolished electroretinogram (ERG) (HP:0000550)1.73408788
179Metabolic acidosis (HP:0001942)1.73270811
180Microretrognathia (HP:0000308)1.71738959
181Labial hypoplasia (HP:0000066)1.69643292
182Aplasia/hypoplasia of the uterus (HP:0008684)1.68472203
183Chronic hepatic failure (HP:0100626)1.68053391
184Abnormality of the nasal septum (HP:0000419)1.67823845
185Hypoplastic female external genitalia (HP:0012815)1.66262108
186Dehydration (HP:0001944)1.64936215
187Renal salt wasting (HP:0000127)1.64125745
188Tubular atrophy (HP:0000092)1.64051043
189Lip pit (HP:0100267)1.63952675
190Glomerulosclerosis (HP:0000096)1.63818396
191Abnormal urine phosphate concentration (HP:0012599)1.63218908
192Male pseudohermaphroditism (HP:0000037)1.63003679
193Lethargy (HP:0001254)1.61883271
194Abnormality of the renal cortex (HP:0011035)1.60578537
195Bilateral microphthalmos (HP:0007633)1.59331993

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B6.18737824
2EPHA25.08118857
3MAP4K14.12292327
4EEF2K3.95451149
5RIPK42.82037471
6NME12.77150869
7STK392.70532039
8MST42.62711911
9TBK12.53584004
10ERN12.48386453
11PDK22.48304923
12OXSR12.45721443
13TYK22.36305271
14TAOK32.28865016
15WNK42.24855253
16BLK2.20583712
17JAK32.18807599
18GRK62.14573916
19KIT2.10204146
20PKN22.05393005
21MET2.03952579
22FRK2.03146669
23STK101.97489979
24TLK11.96791345
25MAP3K101.89051708
26BTK1.88402032
27ZAP701.86332750
28TXK1.86085010
29BMPR1B1.84627734
30MATK1.82147963
31IKBKE1.81874940
32IRAK41.76939878
33TTK1.73851878
34ZAK1.72662322
35STK241.72639264
36SYK1.67980352
37MAP3K141.67759572
38TRIB31.65736873
39JAK11.65494959
40LRRK21.64625208
41EPHB11.54025473
42BRSK21.52067262
43CSF1R1.51825996
44GRK11.51774935
45STK38L1.48880591
46TNIK1.43440215
47PTK61.38245386
48NME21.37752869
49SIK21.35484288
50NUAK11.34387988
51PIM21.29977454
52SCYL21.29960775
53TESK11.27754819
54FES1.25799354
55IRAK31.25624140
56ADRBK21.25444544
57STK31.24180032
58CASK1.23431476
59PRKCI1.21754000
60LCK1.21293831
61LATS11.18735769
62PIM11.18697988
63IKBKB1.16140599
64FGFR31.13342713
65TEC1.11818573
66TSSK61.10413411
67MST1R1.09044117
68CSK1.08615524
69HCK1.08257086
70LMTK21.06219031
71RIPK11.03199101
72ITK1.02861711
73MAP3K131.02351695
74MKNK21.02176882
75FER1.00525112
76TGFBR11.00521818
77MAP3K20.99400285
78PBK0.95876755
79JAK20.95558668
80MAPK150.94212704
81SIK10.91976244
82FLT30.91841253
83DAPK20.90085379
84PRKG20.90065441
85CAMK1D0.90056193
86TAOK10.88460384
87PDK10.86407400
88MAP2K30.85612735
89LYN0.84969483
90MAPKAPK30.84900792
91RPS6KB20.80549179
92TNK20.80498804
93BMX0.78905527
94ERBB20.78797170
95MAP3K120.75462621
96FGFR40.73808857
97FGFR20.72964769
98RET0.72752199
99CLK10.72543611
100TESK20.71582666
101MAP3K80.69557504
102TRPM70.69369872
103KSR20.69316187
104MAP2K20.67101766
105PASK0.67080405
106CHUK0.64040420
107IRAK10.63668272
108PRKAA20.62892022
109ALK0.60978441
110CAMK1G0.60071327
111CDK60.60039321
112MAP4K20.55567405
113MARK30.55173054
114TRIM280.52786703
115PLK40.51385819
116STK40.49578750
117WNK30.48688171
118RPS6KA20.48128258
119MELK0.48122687
120EPHA30.48041901
121INSRR0.47687811
122SRPK10.47183704
123PDPK10.46864387
124AKT30.46673796
125NEK90.45754460
126PIK3CA0.45681613
127BCR0.44764234
128NEK20.43019341
129MAP3K10.42988675
130CDK190.42753446
131NEK60.42628861
132PRKCQ0.42535014
133MAP2K60.41149699
134SIK30.41120754
135MAPK110.41112538
136PLK10.40317835
137NLK0.39884179
138FGFR10.39316972
139PRKCZ0.39071317
140MAP3K70.38689466
141EIF2AK30.38570393
142MAPKAPK20.38271910
143CDK40.37953839
144TGFBR20.37912732
145PAK40.37603336
146RPS6KA40.37310074
147MAP3K110.36128726
148PLK30.35189930
149MAPK40.34435643
150CSNK1A10.33429390
151FGR0.33422379
152PRKCE0.29275293
153PRKCA0.28811720
154YES10.26844280
155IGF1R0.26718267
156EPHB20.26065774
157STK110.25859072
158MKNK10.25837382
159PINK10.23802930
160BUB10.23271812
161RPS6KA60.20830887

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.83521863
2Vitamin digestion and absorption_Homo sapiens_hsa049773.57929598
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.74744973
4Leishmaniasis_Homo sapiens_hsa051402.57818869
5Histidine metabolism_Homo sapiens_hsa003402.57594488
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.41208508
7Primary immunodeficiency_Homo sapiens_hsa053402.40382672
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.40328757
9Linoleic acid metabolism_Homo sapiens_hsa005912.36802768
10Arginine biosynthesis_Homo sapiens_hsa002202.28261566
11B cell receptor signaling pathway_Homo sapiens_hsa046622.26894823
12Chemical carcinogenesis_Homo sapiens_hsa052042.23094288
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.20723402
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.16498371
15Renin-angiotensin system_Homo sapiens_hsa046142.16347250
16Osteoclast differentiation_Homo sapiens_hsa043802.11538637
17Intestinal immune network for IgA production_Homo sapiens_hsa046722.10238411
18Retinol metabolism_Homo sapiens_hsa008302.10180902
19Sulfur metabolism_Homo sapiens_hsa009202.09262936
20Measles_Homo sapiens_hsa051621.94317457
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.93029521
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.90508699
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.87595476
24Antigen processing and presentation_Homo sapiens_hsa046121.86718978
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.85740499
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.83961710
27Starch and sucrose metabolism_Homo sapiens_hsa005001.83923198
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.80673727
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.78825619
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.77985228
31Toxoplasmosis_Homo sapiens_hsa051451.77961747
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.76708084
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.74866212
34Caffeine metabolism_Homo sapiens_hsa002321.67521980
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.65983968
36Nitrogen metabolism_Homo sapiens_hsa009101.60232566
37Influenza A_Homo sapiens_hsa051641.60171770
38Hematopoietic cell lineage_Homo sapiens_hsa046401.59820782
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59503868
40Allograft rejection_Homo sapiens_hsa053301.54037799
41Tuberculosis_Homo sapiens_hsa051521.53365058
42Fatty acid degradation_Homo sapiens_hsa000711.52774769
43Tryptophan metabolism_Homo sapiens_hsa003801.52349968
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.51402456
45Ether lipid metabolism_Homo sapiens_hsa005651.50248103
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.50049943
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.49567057
48Pertussis_Homo sapiens_hsa051331.49378620
49Acute myeloid leukemia_Homo sapiens_hsa052211.48462905
50Graft-versus-host disease_Homo sapiens_hsa053321.48164994
51Legionellosis_Homo sapiens_hsa051341.47757165
52Salmonella infection_Homo sapiens_hsa051321.47742766
53Arginine and proline metabolism_Homo sapiens_hsa003301.47444022
54Shigellosis_Homo sapiens_hsa051311.45959955
55Carbohydrate digestion and absorption_Homo sapiens_hsa049731.44961732
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.43594947
57Jak-STAT signaling pathway_Homo sapiens_hsa046301.43355333
58Arachidonic acid metabolism_Homo sapiens_hsa005901.42473202
59T cell receptor signaling pathway_Homo sapiens_hsa046601.40171293
60Primary bile acid biosynthesis_Homo sapiens_hsa001201.39876898
61Mineral absorption_Homo sapiens_hsa049781.39261548
62Leukocyte transendothelial migration_Homo sapiens_hsa046701.34491922
63Glutathione metabolism_Homo sapiens_hsa004801.33839680
64TNF signaling pathway_Homo sapiens_hsa046681.33383179
65Apoptosis_Homo sapiens_hsa042101.32527539
66Asthma_Homo sapiens_hsa053101.30706095
67Chemokine signaling pathway_Homo sapiens_hsa040621.28196075
68Prolactin signaling pathway_Homo sapiens_hsa049171.27880974
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27722130
70Hepatitis B_Homo sapiens_hsa051611.27431762
71Peroxisome_Homo sapiens_hsa041461.27231763
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26447243
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25487851
74Herpes simplex infection_Homo sapiens_hsa051681.22026977
75Chronic myeloid leukemia_Homo sapiens_hsa052201.21007419
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.20289782
77Hepatitis C_Homo sapiens_hsa051601.16065224
78Platelet activation_Homo sapiens_hsa046111.15467285
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.15032511
80Selenocompound metabolism_Homo sapiens_hsa004501.14846846
81Bile secretion_Homo sapiens_hsa049761.12826735
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12525535
83Butanoate metabolism_Homo sapiens_hsa006501.08511258
84Galactose metabolism_Homo sapiens_hsa000521.08193931
85Pancreatic cancer_Homo sapiens_hsa052121.08100587
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07701211
87Glycerolipid metabolism_Homo sapiens_hsa005611.07410125
88Propanoate metabolism_Homo sapiens_hsa006401.05641603
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04800791
90PPAR signaling pathway_Homo sapiens_hsa033201.04343118
91VEGF signaling pathway_Homo sapiens_hsa043701.00977065
92Phenylalanine metabolism_Homo sapiens_hsa003601.00241348
93Fat digestion and absorption_Homo sapiens_hsa049751.00137882
94Pyruvate metabolism_Homo sapiens_hsa006200.99849361
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99283465
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98964557
97Sphingolipid metabolism_Homo sapiens_hsa006000.97460980
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.96735624
99Fatty acid metabolism_Homo sapiens_hsa012120.95711622
100Other glycan degradation_Homo sapiens_hsa005110.94183798
101Viral myocarditis_Homo sapiens_hsa054160.94068227
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92977700
103Fatty acid biosynthesis_Homo sapiens_hsa000610.92206644
104African trypanosomiasis_Homo sapiens_hsa051430.91083826
105ABC transporters_Homo sapiens_hsa020100.90438500
106Cysteine and methionine metabolism_Homo sapiens_hsa002700.88955158
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.85751642
108Fatty acid elongation_Homo sapiens_hsa000620.84787491
109Tyrosine metabolism_Homo sapiens_hsa003500.84620613
110Non-small cell lung cancer_Homo sapiens_hsa052230.84370088
111Malaria_Homo sapiens_hsa051440.79663289
112Metabolic pathways_Homo sapiens_hsa011000.72676792
113Protein digestion and absorption_Homo sapiens_hsa049740.72636998
114beta-Alanine metabolism_Homo sapiens_hsa004100.72421473
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71406633
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71236927
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70843180
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68819754
119HIF-1 signaling pathway_Homo sapiens_hsa040660.68740582
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67224655
121N-Glycan biosynthesis_Homo sapiens_hsa005100.67010487
122Viral carcinogenesis_Homo sapiens_hsa052030.66676455
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66011212
124Pentose phosphate pathway_Homo sapiens_hsa000300.65981220
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64906602
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64254398
127Small cell lung cancer_Homo sapiens_hsa052220.63610786
128Lysosome_Homo sapiens_hsa041420.63223613
129Rheumatoid arthritis_Homo sapiens_hsa053230.63119617
130Inositol phosphate metabolism_Homo sapiens_hsa005620.61567513
131Thyroid cancer_Homo sapiens_hsa052160.56750032
132Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56496601
133Amoebiasis_Homo sapiens_hsa051460.56200504
134Type I diabetes mellitus_Homo sapiens_hsa049400.56133311
135Autoimmune thyroid disease_Homo sapiens_hsa053200.56055754
136Homologous recombination_Homo sapiens_hsa034400.55918844
137Colorectal cancer_Homo sapiens_hsa052100.55829553
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.55572084
139Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55102757
140Type II diabetes mellitus_Homo sapiens_hsa049300.54649921
141Steroid biosynthesis_Homo sapiens_hsa001000.54455275
142Endocytosis_Homo sapiens_hsa041440.52305021
143Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51965780
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51530058
145Tight junction_Homo sapiens_hsa045300.51021654
146Epstein-Barr virus infection_Homo sapiens_hsa051690.50791237
147Endometrial cancer_Homo sapiens_hsa052130.49775792
148Central carbon metabolism in cancer_Homo sapiens_hsa052300.47963171
149Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47244405
150Sulfur relay system_Homo sapiens_hsa041220.46606424
151Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46532355
152Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46292529
153Phagosome_Homo sapiens_hsa041450.46130572
154One carbon pool by folate_Homo sapiens_hsa006700.45652549
155Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44635538
156Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44534163
157Fructose and mannose metabolism_Homo sapiens_hsa000510.44307491
158Insulin resistance_Homo sapiens_hsa049310.43754703
159mTOR signaling pathway_Homo sapiens_hsa041500.43262611
160Non-homologous end-joining_Homo sapiens_hsa034500.42713606
161Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40914358
162Glycosaminoglycan degradation_Homo sapiens_hsa005310.40414708
163Glioma_Homo sapiens_hsa052140.39788758
164Adipocytokine signaling pathway_Homo sapiens_hsa049200.39256563
165HTLV-I infection_Homo sapiens_hsa051660.39208246
166Carbon metabolism_Homo sapiens_hsa012000.38310767
167Thyroid hormone synthesis_Homo sapiens_hsa049180.38012814
168Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36353703
169Biosynthesis of amino acids_Homo sapiens_hsa012300.36304397
170Pancreatic secretion_Homo sapiens_hsa049720.30733239
171RNA polymerase_Homo sapiens_hsa030200.26670374
172Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.26221458
173Ovarian steroidogenesis_Homo sapiens_hsa049130.22513046
174Phototransduction_Homo sapiens_hsa047440.20504088
175Mismatch repair_Homo sapiens_hsa034300.20121626
176Purine metabolism_Homo sapiens_hsa002300.18070256
177Huntingtons disease_Homo sapiens_hsa050160.15253129
178Lysine degradation_Homo sapiens_hsa003100.15141441
179Base excision repair_Homo sapiens_hsa034100.14719730
180RNA degradation_Homo sapiens_hsa030180.14507227
181Pyrimidine metabolism_Homo sapiens_hsa002400.12241495
182Folate biosynthesis_Homo sapiens_hsa007900.10146691

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