CORO2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.02303377
2locomotory exploration behavior (GO:0035641)5.73553026
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.65984018
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.52668553
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.23428253
6postsynaptic membrane organization (GO:0001941)5.18781672
7synaptic vesicle exocytosis (GO:0016079)4.95292691
8glutamate secretion (GO:0014047)4.78677079
9vocalization behavior (GO:0071625)4.75837078
10regulation of synaptic vesicle exocytosis (GO:2000300)4.71682805
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.69867116
12neuronal action potential propagation (GO:0019227)4.61772573
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.40942326
14presynaptic membrane assembly (GO:0097105)4.36784270
15presynaptic membrane organization (GO:0097090)4.34832784
16regulation of glutamate receptor signaling pathway (GO:1900449)4.29941642
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.29890992
18neurotransmitter secretion (GO:0007269)4.21352254
19regulation of neuronal synaptic plasticity (GO:0048168)4.14454780
20regulation of synaptic vesicle transport (GO:1902803)4.14350910
21layer formation in cerebral cortex (GO:0021819)4.13508621
22cellular potassium ion homeostasis (GO:0030007)4.12519716
23synaptic transmission, glutamatergic (GO:0035249)4.08869611
24axon ensheathment in central nervous system (GO:0032291)4.04346275
25central nervous system myelination (GO:0022010)4.04346275
26protein localization to synapse (GO:0035418)4.04259732
27exploration behavior (GO:0035640)4.02329871
28regulation of synapse structural plasticity (GO:0051823)3.98801392
29regulation of long-term neuronal synaptic plasticity (GO:0048169)3.97214330
30gamma-aminobutyric acid transport (GO:0015812)3.96090746
31sodium ion export (GO:0071436)3.90691376
32dendritic spine morphogenesis (GO:0060997)3.89159688
33glutamate receptor signaling pathway (GO:0007215)3.89154389
34amino acid import (GO:0043090)3.84823699
35long-term memory (GO:0007616)3.78306784
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.77941678
37neuron-neuron synaptic transmission (GO:0007270)3.75508251
38neuron cell-cell adhesion (GO:0007158)3.72445700
39neurotransmitter-gated ion channel clustering (GO:0072578)3.71390403
40cerebellar Purkinje cell differentiation (GO:0021702)3.65557689
41cerebellar granule cell differentiation (GO:0021707)3.63898475
42positive regulation of membrane potential (GO:0045838)3.60647892
43neuromuscular process controlling balance (GO:0050885)3.60124683
44auditory behavior (GO:0031223)3.57470843
45transmission of nerve impulse (GO:0019226)3.55067400
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.53592396
47positive regulation of dendritic spine development (GO:0060999)3.53420322
48positive regulation of dendritic spine morphogenesis (GO:0061003)3.52796344
49cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.52689723
50positive regulation of synapse maturation (GO:0090129)3.50018521
51regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.47015690
52cell communication by electrical coupling (GO:0010644)3.40055553
53neuromuscular process controlling posture (GO:0050884)3.39780007
54neurotransmitter transport (GO:0006836)3.39360145
55response to auditory stimulus (GO:0010996)3.35400676
56regulation of postsynaptic membrane potential (GO:0060078)3.34476777
57positive regulation of synaptic transmission, GABAergic (GO:0032230)3.30864030
58glycine transport (GO:0015816)3.30664915
59synaptic vesicle endocytosis (GO:0048488)3.30599195
60G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.30324924
61regulation of synaptic plasticity (GO:0048167)3.30096639
62regulation of neurotransmitter secretion (GO:0046928)3.29285445
63activation of protein kinase A activity (GO:0034199)3.28801673
64neuronal ion channel clustering (GO:0045161)3.28468645
65regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.28004966
66dendrite morphogenesis (GO:0048813)3.24881564
67response to pheromone (GO:0019236)3.24474379
68positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.23495779
69proline transport (GO:0015824)3.22838563
70positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.22289984
71prepulse inhibition (GO:0060134)3.21525127
72membrane depolarization during action potential (GO:0086010)3.19506425
73regulation of dendritic spine morphogenesis (GO:0061001)3.17575753
74potassium ion import (GO:0010107)3.16502404
75regulation of dendritic spine development (GO:0060998)3.15574898
76membrane hyperpolarization (GO:0060081)3.14937082
77regulation of synaptic transmission, glutamatergic (GO:0051966)3.14181836
78regulation of neurotransmitter levels (GO:0001505)3.13376905
79innervation (GO:0060384)3.13114807
80long-term synaptic potentiation (GO:0060291)3.11441168
81cerebellar Purkinje cell layer development (GO:0021680)3.10857057
82cerebral cortex radially oriented cell migration (GO:0021799)3.10788115
83gamma-aminobutyric acid signaling pathway (GO:0007214)3.10061121
84regulation of neurotransmitter transport (GO:0051588)3.09583188
85regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.09211570
86L-amino acid import (GO:0043092)3.07667317
87regulation of vesicle fusion (GO:0031338)3.07493140
88adult walking behavior (GO:0007628)3.07441337
89establishment of mitochondrion localization (GO:0051654)3.06757988
90cell migration in hindbrain (GO:0021535)3.05991774
91chemosensory behavior (GO:0007635)3.05844778
92neuron recognition (GO:0008038)3.04346162
93membrane depolarization (GO:0051899)3.03513421
94positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.01194350
95potassium ion homeostasis (GO:0055075)3.00003403
96acidic amino acid transport (GO:0015800)2.99861959
97positive regulation of neurotransmitter secretion (GO:0001956)2.97947741
98regulation of ARF protein signal transduction (GO:0032012)2.97412482
99neuromuscular process (GO:0050905)2.97365544
100regulation of voltage-gated calcium channel activity (GO:1901385)2.97242953
101axonal fasciculation (GO:0007413)2.97145331
102dendritic spine organization (GO:0097061)2.96224637
103negative regulation of dendrite morphogenesis (GO:0050774)2.95887268
104cell differentiation in hindbrain (GO:0021533)2.95643537
105positive regulation of neurotransmitter transport (GO:0051590)2.95452684
106positive regulation of synapse assembly (GO:0051965)2.95013400
107mating behavior (GO:0007617)2.94846720
108central nervous system projection neuron axonogenesis (GO:0021952)2.94730671
109regulation of synapse maturation (GO:0090128)2.93357341
110regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.92391160
111negative regulation of synaptic transmission, GABAergic (GO:0032229)2.90039698
112mechanosensory behavior (GO:0007638)2.87813978
113negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.86902030
114neurotransmitter uptake (GO:0001504)2.85563222
115cellular sodium ion homeostasis (GO:0006883)2.85359700
116membrane repolarization (GO:0086009)2.84923671
117positive regulation of potassium ion transmembrane transport (GO:1901381)2.84110602
118synapse assembly (GO:0007416)2.83431237
119neuromuscular synaptic transmission (GO:0007274)2.82762960
120negative regulation of dendrite development (GO:2000171)2.82532205
121long term synaptic depression (GO:0060292)2.81680263
122regulation of synaptic transmission (GO:0050804)2.81527888
123regulation of dendrite morphogenesis (GO:0048814)2.79806180
124negative regulation of axonogenesis (GO:0050771)2.78737802

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.56831360
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.13799726
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09754505
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.02534021
5GBX2_23144817_ChIP-Seq_PC3_Human2.90549171
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.85256770
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.85256770
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.75603961
9DROSHA_22980978_ChIP-Seq_HELA_Human2.74631776
10REST_21632747_ChIP-Seq_MESCs_Mouse2.68022879
11* RARB_27405468_Chip-Seq_BRAIN_Mouse2.64807569
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.61060522
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.57087350
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54875463
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54752996
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.51382535
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50725626
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.42538465
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.34991096
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.34870188
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.33064124
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.24541330
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.18485570
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.18027994
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.15344031
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85714152
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.77216000
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73111771
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70635017
30AR_21572438_ChIP-Seq_LNCaP_Human1.60337943
31* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50769733
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.46533828
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44058631
34* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41903574
35RING1B_27294783_Chip-Seq_ESCs_Mouse1.39845532
36KDM2B_26808549_Chip-Seq_K562_Human1.39689524
37SMAD4_21799915_ChIP-Seq_A2780_Human1.38196617
38RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.38151806
39* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34898198
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32867342
41DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30760839
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29947194
43WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29819907
44RING1B_27294783_Chip-Seq_NPCs_Mouse1.29336729
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27784156
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27509620
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27509201
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27066128
49* AR_19668381_ChIP-Seq_PC3_Human1.24400494
50ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24337649
51ZNF274_21170338_ChIP-Seq_K562_Hela1.21107860
52* SOX2_21211035_ChIP-Seq_LN229_Gbm1.20404396
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18819782
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17805784
55* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16536027
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15690976
57* STAT3_23295773_ChIP-Seq_U87_Human1.14147632
58P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11156670
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10917783
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.10459115
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09080065
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.08517976
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06403494
64GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06140009
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05958244
66* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04934269
67GATA1_26923725_Chip-Seq_HPCs_Mouse1.03983746
68YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03633043
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03601396
70AR_25329375_ChIP-Seq_VCAP_Human1.03343020
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03332037
72CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02726148
73EP300_21415370_ChIP-Seq_HL-1_Mouse1.01865394
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01006085
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01006085
76TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00584287
77CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00435185
78SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99589158
79SMAD3_21741376_ChIP-Seq_ESCs_Human0.98855672
80ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98250311
81CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97986447
82SOX9_26525672_Chip-Seq_HEART_Mouse0.97103889
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96844321
84TET1_21490601_ChIP-Seq_MESCs_Mouse0.96597429
85PIAS1_25552417_ChIP-Seq_VCAP_Human0.96283325
86* SMAD4_21741376_ChIP-Seq_HESCs_Human0.96170572
87* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95506995
88CTCF_27219007_Chip-Seq_Bcells_Human0.95335879
89* P300_19829295_ChIP-Seq_ESCs_Human0.95247735
90AHR_22903824_ChIP-Seq_MCF-7_Human0.95135434
91ARNT_22903824_ChIP-Seq_MCF-7_Human0.94539171
92* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94360431
93* TCF4_23295773_ChIP-Seq_U87_Human0.94125713
94* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93663668
95BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93333223
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92233289
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91790973
98CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91669553
99TAF15_26573619_Chip-Seq_HEK293_Human0.91356691
100RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91156087
101* SMAD3_21741376_ChIP-Seq_HESCs_Human0.90144285
102ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89794775
103* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89598076
104NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88995330
105DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88870399
106* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.88317149
107* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86954436
108SMAD_19615063_ChIP-ChIP_OVARY_Human0.86848738
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86505800
110TP53_18474530_ChIP-ChIP_U2OS_Human0.86299045
111TP53_20018659_ChIP-ChIP_R1E_Mouse0.86269517
112RNF2_27304074_Chip-Seq_NSC_Mouse0.86227453
113SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86110039
114RXR_22108803_ChIP-Seq_LS180_Human0.84625215
115* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84510266
116THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84203325
117* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83005643
118TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82463506

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.32264180
2MP0003635_abnormal_synaptic_transmissio3.96755583
3MP0003880_abnormal_central_pattern3.83429037
4MP0004270_analgesia3.66949559
5MP0009046_muscle_twitch3.18703319
6MP0009745_abnormal_behavioral_response3.16145230
7MP0002063_abnormal_learning/memory/cond3.07347729
8MP0002064_seizures3.04882743
9MP0002822_catalepsy2.81617618
10MP0005423_abnormal_somatic_nervous2.79420938
11MP0001968_abnormal_touch/_nociception2.73637917
12MP0002272_abnormal_nervous_system2.69416835
13MP0002734_abnormal_mechanical_nocicepti2.64949751
14MP0002572_abnormal_emotion/affect_behav2.59916521
15MP0001486_abnormal_startle_reflex2.59002020
16MP0008569_lethality_at_weaning2.32328117
17MP0002735_abnormal_chemical_nociception2.29305613
18MP0002736_abnormal_nociception_after2.09964993
19MP0002733_abnormal_thermal_nociception2.01494188
20MP0002067_abnormal_sensory_capabilities1.99627093
21MP0004858_abnormal_nervous_system1.98070447
22MP0001970_abnormal_pain_threshold1.97557798
23MP0001440_abnormal_grooming_behavior1.90925204
24MP0002184_abnormal_innervation1.89480899
25MP0004885_abnormal_endolymph1.88747551
26MP0002909_abnormal_adrenal_gland1.87427712
27MP0001501_abnormal_sleep_pattern1.85438853
28MP0009780_abnormal_chondrocyte_physiolo1.84954382
29MP0000778_abnormal_nervous_system1.84654568
30MP0003329_amyloid_beta_deposits1.75850499
31MP0004811_abnormal_neuron_physiology1.72572698
32MP0000955_abnormal_spinal_cord1.71115577
33MP0002557_abnormal_social/conspecific_i1.71100236
34MP0004924_abnormal_behavior1.62021980
35MP0005386_behavior/neurological_phenoty1.62021980
36MP0005646_abnormal_pituitary_gland1.61550984
37MP0002882_abnormal_neuron_morphology1.55671245
38MP0001984_abnormal_olfaction1.49510275
39MP0003283_abnormal_digestive_organ1.49136316
40MP0002066_abnormal_motor_capabilities/c1.45356812
41MP0005551_abnormal_eye_electrophysiolog1.43816328
42MP0003633_abnormal_nervous_system1.43306413
43MP0001502_abnormal_circadian_rhythm1.43085671
44MP0004145_abnormal_muscle_electrophysio1.37030671
45MP0000920_abnormal_myelination1.30851032
46MP0004142_abnormal_muscle_tone1.29074462
47MP0003631_nervous_system_phenotype1.24562736
48MP0003787_abnormal_imprinting1.21989224
49MP0003879_abnormal_hair_cell1.21886144
50MP0002229_neurodegeneration1.21619923
51MP0002653_abnormal_ependyma_morphology1.20664394
52MP0001529_abnormal_vocalization1.18882741
53MP0002152_abnormal_brain_morphology1.18087923
54MP0003123_paternal_imprinting1.17803514
55MP0003634_abnormal_glial_cell1.16595027
56MP0003690_abnormal_glial_cell1.15893051
57MP0006276_abnormal_autonomic_nervous1.14985207
58MP0005645_abnormal_hypothalamus_physiol1.12774402
59MP0000013_abnormal_adipose_tissue1.12608862
60MP0006072_abnormal_retinal_apoptosis1.11308869
61MP0001905_abnormal_dopamine_level1.10845141
62MP0003632_abnormal_nervous_system1.08709332
63MP0004742_abnormal_vestibular_system1.06585176
64MP0010386_abnormal_urinary_bladder1.05264004
65MP0008961_abnormal_basal_metabolism1.02726213
66MP0005171_absent_coat_pigmentation1.00907235
67MP0003122_maternal_imprinting1.00325379
68MP0002090_abnormal_vision0.96800193
69MP0002638_abnormal_pupillary_reflex0.95932574
70MP0002752_abnormal_somatic_nervous0.94958066
71MP0002069_abnormal_eating/drinking_beha0.91740968
72MP0005253_abnormal_eye_physiology0.90571694
73MP0005167_abnormal_blood-brain_barrier0.90566657
74MP0005499_abnormal_olfactory_system0.87296873
75MP0005394_taste/olfaction_phenotype0.87296873
76MP0001177_atelectasis0.85998409
77MP0000751_myopathy0.85492943
78MP0004043_abnormal_pH_regulation0.85406394
79MP0004085_abnormal_heartbeat0.85189783
80MP0000026_abnormal_inner_ear0.82931036
81MP0001485_abnormal_pinna_reflex0.82283478
82MP0001963_abnormal_hearing_physiology0.81481847
83MP0003137_abnormal_impulse_conducting0.81029164
84MP0008872_abnormal_physiological_respon0.80481116
85MP0000631_abnormal_neuroendocrine_gland0.78383770
86MP0003075_altered_response_to0.77967120
87MP0001299_abnormal_eye_distance/0.77181420
88MP0003121_genomic_imprinting0.72233571
89MP0008874_decreased_physiological_sensi0.71903474
90MP0000569_abnormal_digit_pigmentation0.71347188
91MP0005623_abnormal_meninges_morphology0.71215611
92MP0002249_abnormal_larynx_morphology0.69722875
93MP0000566_synostosis0.68998245
94MP0003861_abnormal_nervous_system0.67321647
95MP0004215_abnormal_myocardial_fiber0.67153874
96MP0001188_hyperpigmentation0.65865101
97MP0004233_abnormal_muscle_weight0.64757139
98MP0000579_abnormal_nail_morphology0.64711164
99MP0005535_abnormal_body_temperature0.64690425
100MP0003938_abnormal_ear_development0.61659723
101MP0001958_emphysema0.60854768
102MP0002082_postnatal_lethality0.59919422
103MP0010770_preweaning_lethality0.59919422
104MP0000604_amyloidosis0.59438805
105MP0003705_abnormal_hypodermis_morpholog0.59422671
106MP0001943_abnormal_respiration0.59177414
107MP0005187_abnormal_penis_morphology0.58952410
108MP0001986_abnormal_taste_sensitivity0.58707196
109MP0005409_darkened_coat_color0.58593851
110MP0000534_abnormal_ureter_morphology0.58363575
111MP0002081_perinatal_lethality0.57467312
112MP0010769_abnormal_survival0.57435159
113MP0010768_mortality/aging0.57157993
114MP0002234_abnormal_pharynx_morphology0.56773511
115MP0000747_muscle_weakness0.55545523
116MP0003385_abnormal_body_wall0.55447966
117MP0001346_abnormal_lacrimal_gland0.51854751

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.76050991
2Focal motor seizures (HP:0011153)6.19274000
3Focal seizures (HP:0007359)5.02369976
4Visual hallucinations (HP:0002367)4.97727087
5Action tremor (HP:0002345)4.93823205
6Progressive cerebellar ataxia (HP:0002073)4.69849661
7Epileptic encephalopathy (HP:0200134)4.27840686
8Atonic seizures (HP:0010819)4.03239754
9Febrile seizures (HP:0002373)3.85117512
10Supranuclear gaze palsy (HP:0000605)3.74597249
11Obstructive sleep apnea (HP:0002870)3.50049796
12Absence seizures (HP:0002121)3.46069812
13Gaze-evoked nystagmus (HP:0000640)3.40344902
14Ankle clonus (HP:0011448)3.33441144
15Dysmetria (HP:0001310)3.28813479
16Dysdiadochokinesis (HP:0002075)3.26697920
17Generalized tonic-clonic seizures (HP:0002069)3.22376145
18Depression (HP:0000716)3.22255234
19Dialeptic seizures (HP:0011146)3.19053460
20Intention tremor (HP:0002080)3.11043898
21Scanning speech (HP:0002168)3.09031094
22Broad-based gait (HP:0002136)3.07304797
23Poor eye contact (HP:0000817)3.00898124
24Truncal ataxia (HP:0002078)2.96380324
25Anxiety (HP:0000739)2.93099751
26Impaired vibration sensation in the lower limbs (HP:0002166)2.92810490
27Megalencephaly (HP:0001355)2.90506159
28Amblyopia (HP:0000646)2.88448194
29Hemiplegia (HP:0002301)2.86835639
30Genetic anticipation (HP:0003743)2.86601898
31Hemiparesis (HP:0001269)2.85648430
32Spastic gait (HP:0002064)2.77006302
33Impaired smooth pursuit (HP:0007772)2.75036297
34Neurofibrillary tangles (HP:0002185)2.74972685
35Impaired social interactions (HP:0000735)2.74868560
36Abnormal social behavior (HP:0012433)2.74868560
37Postural instability (HP:0002172)2.71700256
38Urinary bladder sphincter dysfunction (HP:0002839)2.63967229
39Annular pancreas (HP:0001734)2.63326234
40Abnormal eating behavior (HP:0100738)2.59503850
41Sleep apnea (HP:0010535)2.55502392
42Abnormality of the lower motor neuron (HP:0002366)2.52787256
43Ventricular fibrillation (HP:0001663)2.52456041
44Diplopia (HP:0000651)2.50587686
45Abnormality of binocular vision (HP:0011514)2.50587686
46Abnormality of ocular smooth pursuit (HP:0000617)2.44996788
47Abnormality of the corticospinal tract (HP:0002492)2.43140260
48Mutism (HP:0002300)2.42055708
49Torticollis (HP:0000473)2.41463405
50Pheochromocytoma (HP:0002666)2.41072073
51Cerebral hypomyelination (HP:0006808)2.37750103
52Papilledema (HP:0001085)2.36458050
53Epileptiform EEG discharges (HP:0011182)2.36139818
54Hyperventilation (HP:0002883)2.36019974
55Stereotypic behavior (HP:0000733)2.35916794
56EEG with generalized epileptiform discharges (HP:0011198)2.34703926
57Turricephaly (HP:0000262)2.33398125
58Dysmetric saccades (HP:0000641)2.32743782
59Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.31785895
60Cerebral inclusion bodies (HP:0100314)2.31394264
61Urinary urgency (HP:0000012)2.30949700
62Hypsarrhythmia (HP:0002521)2.27609755
63Insomnia (HP:0100785)2.27464750
64Akinesia (HP:0002304)2.26483509
65Focal dystonia (HP:0004373)2.25988611
66Agitation (HP:0000713)2.23825467
67Pointed chin (HP:0000307)2.19330080
68Central scotoma (HP:0000603)2.15844421
69Termporal pattern (HP:0011008)2.14365670
70Insidious onset (HP:0003587)2.14365670
71Lower limb muscle weakness (HP:0007340)2.14317531
72Excessive salivation (HP:0003781)2.08712366
73Drooling (HP:0002307)2.08712366
74Postural tremor (HP:0002174)2.07374091
75Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.06650797
76Degeneration of the lateral corticospinal tracts (HP:0002314)2.06650797
77Hand muscle atrophy (HP:0009130)2.05399391
78Split foot (HP:0001839)2.04756960
79Bundle branch block (HP:0011710)2.04583877
80Shallow orbits (HP:0000586)2.03853428
81Gait ataxia (HP:0002066)2.03409520
82Limb dystonia (HP:0002451)2.02741067
83Bradykinesia (HP:0002067)2.02737633
84Progressive inability to walk (HP:0002505)2.00170484
85Clonus (HP:0002169)1.96813441
86Absent speech (HP:0001344)1.96669455
87Bronchomalacia (HP:0002780)1.96656070
88Neuroendocrine neoplasm (HP:0100634)1.96528005
89Impaired vibratory sensation (HP:0002495)1.94858660
90Mild short stature (HP:0003502)1.94344602
91Polyphagia (HP:0002591)1.93775508
92Neoplasm of the heart (HP:0100544)1.93598239
93Hypoventilation (HP:0002791)1.93510326
94Abnormality of saccadic eye movements (HP:0000570)1.93280345
95Status epilepticus (HP:0002133)1.92747192
96Craniofacial dystonia (HP:0012179)1.92660083
97Distal upper limb amyotrophy (HP:0007149)1.92026008
98Upper limb amyotrophy (HP:0009129)1.92026008
99Fetal akinesia sequence (HP:0001989)1.90325967
100Heterochromia iridis (HP:0001100)1.89754182
101Incomplete penetrance (HP:0003829)1.88334963
102Neuronal loss in central nervous system (HP:0002529)1.87728190
103Delusions (HP:0000746)1.85065200
104Prolonged QT interval (HP:0001657)1.84097021
105Increased circulating renin level (HP:0000848)1.83302051
106Nuclear cataract (HP:0100018)1.81907485
107Spinal canal stenosis (HP:0003416)1.81425383
108Lower limb asymmetry (HP:0100559)1.79906717
109Aplasia involving bones of the extremities (HP:0009825)1.79483575
110Aplasia involving bones of the upper limbs (HP:0009823)1.79483575
111Aplasia of the phalanges of the hand (HP:0009802)1.79483575
112Hammertoe (HP:0001765)1.79303405
113Abnormal EKG (HP:0003115)1.79029963
114Tetraplegia (HP:0002445)1.78288988
115Apathy (HP:0000741)1.75565523
116Rapidly progressive (HP:0003678)1.74414358
117Specific learning disability (HP:0001328)1.74229233
118Rigidity (HP:0002063)1.73093962
119Lower limb amyotrophy (HP:0007210)1.72422466
120Peripheral hypomyelination (HP:0007182)1.71908916
121Generalized myoclonic seizures (HP:0002123)1.71794144
122Morphological abnormality of the pyramidal tract (HP:0002062)1.69348871
123Amyotrophic lateral sclerosis (HP:0007354)1.68541079
124Hypoplasia of the corpus callosum (HP:0002079)1.66528914
125Spastic tetraparesis (HP:0001285)1.64158655
126Abnormality of the diencephalon (HP:0010662)1.63954322

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.13413069
2EPHA43.65822918
3MAP3K93.33687888
4PRKD32.86171478
5MAP3K42.66575224
6PAK62.64337784
7MARK12.52497673
8MINK12.48982896
9KSR22.31189151
10NTRK22.29714952
11DAPK22.16314845
12CAMKK12.10703912
13NTRK12.03071963
14MAP2K71.95853286
15PRPF4B1.67075303
16TYRO31.65728329
17TNIK1.60627495
18CAMKK21.58368452
19CDK51.58362982
20KSR11.57725110
21MAP2K41.51874137
22UHMK11.51424529
23CDK191.45083179
24STK381.43846659
25PNCK1.41443855
26SGK2231.30615575
27SGK4941.30615575
28MAP3K21.30507635
29EPHB21.26804961
30MAPK131.23276759
31GRK51.23199772
32PHKG21.20727803
33PHKG11.20727803
34PRKCH1.16726124
35PKN11.16363484
36WNK11.14925304
37LMTK21.11590372
38PRKCG1.11481768
39RIPK11.11272814
40OXSR11.09808196
41SIK21.05824597
42FES1.02134351
43ARAF1.02061088
44RET1.01845402
45CDK181.01790003
46PINK11.01455193
47CDK151.01384274
48CAMK10.97932097
49CDK140.97470926
50DAPK10.96365479
51STK110.94353845
52RIPK40.94276354
53MAP3K130.93746654
54MARK20.92569495
55CDK11A0.90058029
56TAOK10.89912701
57CAMK1G0.88847803
58PLK20.88568267
59ALK0.86253716
60SGK20.86134911
61PAK30.86122330
62NEK60.85756399
63CAMK2A0.84107061
64SGK30.83682268
65LIMK10.83237533
66ROCK10.79932167
67CASK0.79321449
68CAMK2B0.78779896
69FGFR20.76753876
70MAP3K10.72725391
71ICK0.71918050
72MAP3K120.69555330
73DYRK1A0.69044973
74SGK10.67857799
75STK390.67305060
76CDC42BPA0.67017845
77DYRK20.65793518
78MOS0.65441973
79PDK10.65428022
80PDPK10.63672660
81PTK20.61164116
82CSNK1G20.58726661
83PTK2B0.58666122
84CAMK40.58253582
85CAMK2D0.55711025
86HIPK20.54874426
87RPS6KA30.54070473
88ROCK20.52831442
89PRKCE0.52802956
90MAPK100.51556595
91RAF10.50246011
92CAMK2G0.50172800
93FYN0.50163426
94BCR0.48827623
95MAPKAPK50.48696007
96PRKCZ0.48571813
97PRKD20.48298335
98NEK10.47702463
99ERBB20.47230068
100PDGFRA0.46697275
101INSRR0.46303928
102FER0.45881256
103LATS20.45045782
104MAPK150.43513933
105MAP3K70.42817484
106MAPK120.42023160
107WNK40.41179750
108TNK20.41148011
109ERBB40.40042542
110MAP2K10.38417839
111BRSK10.38240340
112PRKG10.38071355
113CSNK1G30.34305492
114CSNK1D0.32454552
115CSNK1A1L0.31824637
116DDR20.31453370
117DAPK30.30491726
118CCNB10.29842973
119PDGFRB0.29605241
120MAP4K20.29404811
121MAPK80.29216039

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.21365367
2Synaptic vesicle cycle_Homo sapiens_hsa047213.02847530
3Circadian entrainment_Homo sapiens_hsa047132.67234486
4GABAergic synapse_Homo sapiens_hsa047272.66637551
5Glutamatergic synapse_Homo sapiens_hsa047242.64000584
6Long-term potentiation_Homo sapiens_hsa047202.53137393
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.52041713
8Olfactory transduction_Homo sapiens_hsa047402.49741118
9Morphine addiction_Homo sapiens_hsa050322.38868916
10Amphetamine addiction_Homo sapiens_hsa050312.27512817
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.26219923
12Insulin secretion_Homo sapiens_hsa049112.18246684
13Dopaminergic synapse_Homo sapiens_hsa047282.08967499
14Salivary secretion_Homo sapiens_hsa049702.06117042
15Cholinergic synapse_Homo sapiens_hsa047251.95341955
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.88978286
17Gastric acid secretion_Homo sapiens_hsa049711.82000215
18Long-term depression_Homo sapiens_hsa047301.79308373
19Taste transduction_Homo sapiens_hsa047421.74707809
20Cocaine addiction_Homo sapiens_hsa050301.70833133
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70297593
22Oxytocin signaling pathway_Homo sapiens_hsa049211.57100190
23Serotonergic synapse_Homo sapiens_hsa047261.56452320
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.53529150
25Renin secretion_Homo sapiens_hsa049241.52167703
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49821608
27Calcium signaling pathway_Homo sapiens_hsa040201.44559921
28GnRH signaling pathway_Homo sapiens_hsa049121.43098764
29Nitrogen metabolism_Homo sapiens_hsa009101.42830900
30Type II diabetes mellitus_Homo sapiens_hsa049301.41547679
31Gap junction_Homo sapiens_hsa045401.38643847
32cAMP signaling pathway_Homo sapiens_hsa040241.28988521
33Phototransduction_Homo sapiens_hsa047441.28179507
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28049236
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.25359819
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24228458
37Axon guidance_Homo sapiens_hsa043601.17581607
38Estrogen signaling pathway_Homo sapiens_hsa049151.15526392
39Glioma_Homo sapiens_hsa052141.08778579
40Vitamin B6 metabolism_Homo sapiens_hsa007501.08680727
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07863308
42Melanogenesis_Homo sapiens_hsa049161.03215286
43Phospholipase D signaling pathway_Homo sapiens_hsa040721.02579461
44ErbB signaling pathway_Homo sapiens_hsa040121.01320986
45Pancreatic secretion_Homo sapiens_hsa049721.00361873
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.98061796
47Collecting duct acid secretion_Homo sapiens_hsa049660.95406849
48Dorso-ventral axis formation_Homo sapiens_hsa043200.94975756
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93528617
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91494007
51Thyroid hormone synthesis_Homo sapiens_hsa049180.86670001
52Cardiac muscle contraction_Homo sapiens_hsa042600.84848003
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83207562
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82834910
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82769134
56Oocyte meiosis_Homo sapiens_hsa041140.81962322
57Dilated cardiomyopathy_Homo sapiens_hsa054140.79664280
58Vibrio cholerae infection_Homo sapiens_hsa051100.77795869
59Choline metabolism in cancer_Homo sapiens_hsa052310.76919262
60Circadian rhythm_Homo sapiens_hsa047100.71779658
61MAPK signaling pathway_Homo sapiens_hsa040100.69693551
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.68432311
63VEGF signaling pathway_Homo sapiens_hsa043700.66070093
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66004122
65Hippo signaling pathway_Homo sapiens_hsa043900.65384704
66Endocytosis_Homo sapiens_hsa041440.62736664
67Inositol phosphate metabolism_Homo sapiens_hsa005620.62547836
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.62214284
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61708561
70Ras signaling pathway_Homo sapiens_hsa040140.59695974
71Rap1 signaling pathway_Homo sapiens_hsa040150.59386954
72ECM-receptor interaction_Homo sapiens_hsa045120.59301241
73mTOR signaling pathway_Homo sapiens_hsa041500.57973733
74Renal cell carcinoma_Homo sapiens_hsa052110.57222698
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55854739
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55293232
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55143771
78Glucagon signaling pathway_Homo sapiens_hsa049220.54353747
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54051724
80Focal adhesion_Homo sapiens_hsa045100.53949126
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52691918
82Bile secretion_Homo sapiens_hsa049760.51696080
83Alcoholism_Homo sapiens_hsa050340.49735591
84Wnt signaling pathway_Homo sapiens_hsa043100.49258995
85Endometrial cancer_Homo sapiens_hsa052130.47593015
86Non-small cell lung cancer_Homo sapiens_hsa052230.47350675
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46110391
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45463274
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45393002
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45068357
91Ovarian steroidogenesis_Homo sapiens_hsa049130.43475907
92Type I diabetes mellitus_Homo sapiens_hsa049400.42392298
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42197243
94Protein digestion and absorption_Homo sapiens_hsa049740.41559298
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41263214
96Prion diseases_Homo sapiens_hsa050200.39357882
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38825865
98Insulin signaling pathway_Homo sapiens_hsa049100.38452634
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38173450
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37610559
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36796822
102Chemokine signaling pathway_Homo sapiens_hsa040620.36328899
103Hedgehog signaling pathway_Homo sapiens_hsa043400.36038081
104Histidine metabolism_Homo sapiens_hsa003400.35247533
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33782356
106Tight junction_Homo sapiens_hsa045300.32796025
107AMPK signaling pathway_Homo sapiens_hsa041520.31684086
108beta-Alanine metabolism_Homo sapiens_hsa004100.30552359
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30474186
110Melanoma_Homo sapiens_hsa052180.28829859
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.27298135
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26949921
113Colorectal cancer_Homo sapiens_hsa052100.24030641

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