CORO6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)8.49655443
2cardiac myofibril assembly (GO:0055003)7.54388516
3muscle filament sliding (GO:0030049)7.40147036
4actin-myosin filament sliding (GO:0033275)7.40147036
5negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.34215318
6positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)7.09486334
7myofibril assembly (GO:0030239)7.09083153
8plasma membrane repair (GO:0001778)6.87534911
9regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.71795556
10negative regulation of potassium ion transmembrane transport (GO:1901380)6.69988155
11regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.64304311
12regulation of skeletal muscle contraction (GO:0014819)6.44193180
13cardiac muscle contraction (GO:0060048)6.29446785
14sarcoplasmic reticulum calcium ion transport (GO:0070296)6.13695786
15actin-mediated cell contraction (GO:0070252)6.12892802
16regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.98214470
17regulation of relaxation of muscle (GO:1901077)5.92226194
18regulation of actin filament-based movement (GO:1903115)5.68304708
19regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.65137818
20cardiac muscle cell development (GO:0055013)5.64482158
21tricarboxylic acid cycle (GO:0006099)5.59725209
22regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.57083146
23response to muscle activity (GO:0014850)5.47821081
24striated muscle contraction (GO:0006941)5.45849180
25actomyosin structure organization (GO:0031032)5.44187763
26regulation of cell communication by electrical coupling (GO:0010649)5.41006582
27skeletal muscle fiber development (GO:0048741)5.33522671
28cardiac cell development (GO:0055006)5.27839670
29ventricular cardiac muscle cell action potential (GO:0086005)5.26458923
30cardiac muscle hypertrophy (GO:0003300)5.22360288
31cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.11032055
32adult heart development (GO:0007512)5.05741619
33striated muscle hypertrophy (GO:0014897)5.01255070
34regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.99751419
35carnitine shuttle (GO:0006853)4.92529149
36cardiac muscle tissue morphogenesis (GO:0055008)4.89330033
37regulation of striated muscle contraction (GO:0006942)4.84091167
38myotube cell development (GO:0014904)4.79447660
39regulation of membrane repolarization (GO:0060306)4.79407235
40regulation of sarcomere organization (GO:0060297)4.74061836
41actin filament-based movement (GO:0030048)4.67455049
42cell communication involved in cardiac conduction (GO:0086065)4.67054826
43bundle of His cell to Purkinje myocyte communication (GO:0086069)4.58069646
44regulation of acyl-CoA biosynthetic process (GO:0050812)4.56405168
45ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.53423803
46skeletal muscle contraction (GO:0003009)4.51817090
47muscle tissue morphogenesis (GO:0060415)4.48320276
48cell communication by electrical coupling (GO:0010644)4.45170945
49response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.44898769
50muscle hypertrophy (GO:0014896)4.42829735
51positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.24093378
52heart trabecula formation (GO:0060347)4.22905944
53glycogen catabolic process (GO:0005980)4.22553283
54regulation of the force of heart contraction (GO:0002026)4.21249378
55fatty acid transmembrane transport (GO:1902001)4.21186133
56regulation of cofactor metabolic process (GO:0051193)4.15787745
57regulation of coenzyme metabolic process (GO:0051196)4.15787745
58skeletal muscle tissue development (GO:0007519)4.07288622
59heart contraction (GO:0060047)4.05187026
60heart process (GO:0003015)4.05187026
61cardiac muscle cell action potential (GO:0086001)4.04879840
62regulation of cardiac muscle contraction (GO:0055117)4.04619582
63cardiac muscle cell action potential involved in contraction (GO:0086002)4.00906742
64regulation of cardiac muscle cell contraction (GO:0086004)3.99863482
65glucan catabolic process (GO:0009251)3.94168014
66regulation of calcium ion transmembrane transport (GO:1903169)3.86302066
67regulation of calcium ion transmembrane transporter activity (GO:1901019)3.86302066
68cardiac muscle adaptation (GO:0014887)3.85491990
69cardiac muscle hypertrophy in response to stress (GO:0014898)3.85491990
70muscle hypertrophy in response to stress (GO:0003299)3.85491990
71positive regulation of myotube differentiation (GO:0010831)3.84705155
72muscle contraction (GO:0006936)3.84452889
73negative regulation of potassium ion transport (GO:0043267)3.82984445
74membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.79166202
75regulation of heart rate (GO:0002027)3.78435446
76neuronal action potential propagation (GO:0019227)3.75017287
77glucan biosynthetic process (GO:0009250)3.74130459
78glycogen biosynthetic process (GO:0005978)3.74130459
79muscle cell fate commitment (GO:0042693)3.72030791
80relaxation of cardiac muscle (GO:0055119)3.71834448
81creatine metabolic process (GO:0006600)3.69450800
82negative regulation of protein localization to cell surface (GO:2000009)3.68227213
83cellular polysaccharide catabolic process (GO:0044247)3.67781064
84positive regulation of cation channel activity (GO:2001259)3.67553856
85cardiac conduction (GO:0061337)3.67281762
86response to inactivity (GO:0014854)3.63560416
87carnitine transmembrane transport (GO:1902603)3.63309803
88NADH metabolic process (GO:0006734)3.61334301
89striated muscle cell development (GO:0055002)3.61041878
90muscle cell cellular homeostasis (GO:0046716)3.59406095
91muscle system process (GO:0003012)3.57992385
92striated muscle adaptation (GO:0014888)3.57343237
93regulation of heart contraction (GO:0008016)3.53609260
94regulation of heart rate by cardiac conduction (GO:0086091)3.50713412
95muscle organ development (GO:0007517)3.49700954
96regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.49345246
97negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.48863368
98negative regulation of calcium ion transmembrane transport (GO:1903170)3.48863368
99detection of calcium ion (GO:0005513)3.48035913
100muscle structure development (GO:0061061)3.46280929
101skeletal muscle adaptation (GO:0043501)3.46125432
102regulation of skeletal muscle cell differentiation (GO:2001014)3.43150827
103muscle adaptation (GO:0043500)3.41258608
104negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.38193298
105regulation of ATP catabolic process (GO:1903289)3.38040360
106regulation of ATPase activity (GO:0043462)3.38040360
107relaxation of muscle (GO:0090075)3.36024475
108regulation of sulfur metabolic process (GO:0042762)3.35002548
109positive regulation of heart rate (GO:0010460)3.31514687
1102-oxoglutarate metabolic process (GO:0006103)3.29912993
111amino-acid betaine transport (GO:0015838)3.27879503
112carnitine transport (GO:0015879)3.27879503
113polysaccharide catabolic process (GO:0000272)3.27627266
114oxygen transport (GO:0015671)3.26567461
115regulation of muscle contraction (GO:0006937)3.26015423
116striated muscle atrophy (GO:0014891)3.25297892
117positive regulation of heart contraction (GO:0045823)3.23184022
118positive regulation of potassium ion transmembrane transport (GO:1901381)3.20259657
119skeletal muscle tissue regeneration (GO:0043403)3.18525407
120muscle cell development (GO:0055001)3.18202019
121regulation of muscle system process (GO:0090257)3.17611090
122negative regulation of striated muscle cell apoptotic process (GO:0010664)3.16328941
123mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.15822202
124muscle fiber development (GO:0048747)3.14683869
125regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.10369725
126regulation of cation channel activity (GO:2001257)3.10128305
127gluconeogenesis (GO:0006094)3.10038936
128neuromuscular synaptic transmission (GO:0007274)3.08547152
129regulation of myoblast differentiation (GO:0045661)3.06041872
130myoblast fusion (GO:0007520)3.03608265
131glycogen metabolic process (GO:0005977)3.03048041
132striated muscle tissue development (GO:0014706)2.99313751
133glucan metabolic process (GO:0044042)2.96051126

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.21848952
2EZH2_22144423_ChIP-Seq_EOC_Human3.99059167
3EP300_21415370_ChIP-Seq_HL-1_Mouse3.92755652
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.53219632
5* TBX20_22080862_ChIP-Seq_HEART_Mouse3.23770799
6* TBX20_22328084_ChIP-Seq_HEART_Mouse3.23770799
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.84805466
8ESR1_20079471_ChIP-ChIP_T-47D_Human2.82237942
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.62339854
10MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.31048584
11ZNF263_19887448_ChIP-Seq_K562_Human2.27975896
12DROSHA_22980978_ChIP-Seq_HELA_Human2.21989207
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.13291232
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.11265935
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09940026
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.05037431
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.00955734
18TRIM28_21343339_ChIP-Seq_HEK293_Human1.98387127
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.94351973
20CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.89852689
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.71565429
22EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.71084459
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.64595825
24GATA4_21415370_ChIP-Seq_HL-1_Mouse1.64168732
25NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.59177926
26ERG_21242973_ChIP-ChIP_JURKAT_Human1.53487270
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.49779554
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.49779554
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.49430397
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48719605
31SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47412127
32* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.46749225
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43914036
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.43835195
35NFIB_24661679_ChIP-Seq_LUNG_Mouse1.42637866
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.36672210
37* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36588517
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.32914185
39CTCF_27219007_Chip-Seq_Bcells_Human1.32808683
40BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.32713788
41SMC3_22415368_ChIP-Seq_MEFs_Mouse1.30542162
42ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29573468
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29079770
44NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26790453
45SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24251164
46CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.21244871
47* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20957442
48TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17936416
49SMC4_20622854_ChIP-Seq_HELA_Human1.17033166
50STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.16885911
51PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.14904891
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.14478423
53DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14038256
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.13157060
55TET1_21490601_ChIP-Seq_MESCs_Mouse1.12230673
56CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12050332
57* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11869459
58* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11478169
59* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11349753
60* SOX2_21211035_ChIP-Seq_LN229_Gbm1.09588977
61MYC_27129775_Chip-Seq_CORNEA_Mouse1.09556588
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07518790
63EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06387367
64NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.06037655
65JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05463652
66PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.05409838
67ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05167796
68* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04529661
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04494928
70SMAD3_21741376_ChIP-Seq_HESCs_Human1.04489302
71ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.04349531
72SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04185990
73* TCF7_22412390_ChIP-Seq_EML_Mouse1.03352585
74SA1_27219007_Chip-Seq_Bcells_Human1.03005626
75* KDM2B_26808549_Chip-Seq_DND41_Human1.02929498
76* KDM2B_26808549_Chip-Seq_K562_Human1.01805642
77ZNF274_21170338_ChIP-Seq_K562_Hela1.01689925
78LXR_22292898_ChIP-Seq_THP-1_Human1.01036338
79RNF2_27304074_Chip-Seq_ESCs_Mouse1.00550509
80MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00534243
81SMAD4_21741376_ChIP-Seq_HESCs_Human0.99853874
82TP53_20018659_ChIP-ChIP_R1E_Mouse0.98854446
83ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98615088
84* TP63_22573176_ChIP-Seq_HFKS_Human0.98366598
85SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.97830973
86* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96954988
87RAD21_21589869_ChIP-Seq_MESCs_Mouse0.95001558
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94989305
89PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94260237
90AHR_22903824_ChIP-Seq_MCF-7_Human0.94067438
91SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93337217
92OCT4_19829295_ChIP-Seq_ESCs_Human0.93310715
93CREB1_26743006_Chip-Seq_LNCaP_Human0.92624077
94NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91519982
95PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91385628
96FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.91325063
97EED_16625203_ChIP-ChIP_MESCs_Mouse0.91244023
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91016275
99GATA1_19941826_ChIP-Seq_K562_Human0.90554904
100ISL1_27105846_Chip-Seq_CPCs_Mouse0.89864703
101* TET1_21451524_ChIP-Seq_MESCs_Mouse0.89624143
102* SA1_27219007_Chip-Seq_ERYTHROID_Human0.89324252
103WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88829496
104SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88501748
105GBX2_23144817_ChIP-Seq_PC3_Human0.88084558
106SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.87336872
107NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86704147
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86185800
109AR_19668381_ChIP-Seq_PC3_Human0.85231577
110FOXA2_19822575_ChIP-Seq_HepG2_Human0.84219110
111FOXH1_21741376_ChIP-Seq_ESCs_Human0.84169214
112TP53_23651856_ChIP-Seq_MEFs_Mouse0.83898403
113OCT4_20526341_ChIP-Seq_ESCs_Human0.83812199
114AR_21572438_ChIP-Seq_LNCaP_Human0.83709938
115RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82957989
116SOX9_24532713_ChIP-Seq_HFSC_Mouse0.82553068
117CLOCK_20551151_ChIP-Seq_293T_Human0.82131562
118TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.81609634
119* SMAD4_21799915_ChIP-Seq_A2780_Human0.81068856
120DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.80192941
121RACK7_27058665_Chip-Seq_MCF-7_Human0.80088291
122BCAT_22108803_ChIP-Seq_LS180_Human0.79638849
123ESR1_21235772_ChIP-Seq_MCF-7_Human0.79531766
124P68_20966046_ChIP-Seq_HELA_Human0.79441262
125CJUN_26792858_Chip-Seq_BT549_Human0.79211280
126ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78956132
127SPI1_23127762_ChIP-Seq_K562_Human0.78419279
128RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.78241495
129* REST_18959480_ChIP-ChIP_MESCs_Mouse0.77874247
130TP53_16413492_ChIP-PET_HCT116_Human0.77850082
131GATA1_19941827_ChIP-Seq_MEL_Mouse0.77342568

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.47379907
2MP0003646_muscle_fatigue5.79274952
3MP0000751_myopathy5.64928146
4MP0004084_abnormal_cardiac_muscle5.06231687
5MP0004215_abnormal_myocardial_fiber4.54197910
6MP0000749_muscle_degeneration4.31553433
7MP0004036_abnormal_muscle_relaxation4.11933382
8MP0005330_cardiomyopathy3.61135592
9MP0004145_abnormal_muscle_electrophysio3.28796713
10MP0004087_abnormal_muscle_fiber3.18922079
11MP0002972_abnormal_cardiac_muscle2.93698827
12MP0000750_abnormal_muscle_regeneration2.91055663
13MP0002106_abnormal_muscle_physiology2.82305915
14MP0003137_abnormal_impulse_conducting2.79250652
15MP0005620_abnormal_muscle_contractility2.78008276
16MP0008775_abnormal_heart_ventricle2.61753418
17MP0004130_abnormal_muscle_cell2.59213811
18MP0002269_muscular_atrophy2.51999746
19MP0000747_muscle_weakness2.45266337
20MP0004484_altered_response_of2.43998299
21MP0010630_abnormal_cardiac_muscle2.38031619
22MP0001544_abnormal_cardiovascular_syste2.35892769
23MP0005385_cardiovascular_system_phenoty2.35892769
24MP0005369_muscle_phenotype2.32236911
25MP0000759_abnormal_skeletal_muscle2.28848331
26MP0006138_congestive_heart_failure2.16231747
27MP0004510_myositis2.11686520
28MP0004085_abnormal_heartbeat2.01184174
29MP0004233_abnormal_muscle_weight1.97794848
30MP0003828_pulmonary_edema1.96403921
31MP0003221_abnormal_cardiomyocyte_apopto1.73954156
32MP0002127_abnormal_cardiovascular_syste1.53894336
33MP0006036_abnormal_mitochondrial_physio1.53278666
34MP0002332_abnormal_exercise_endurance1.49438809
35MP0003950_abnormal_plasma_membrane1.43573749
36MP0005666_abnormal_adipose_tissue1.35775630
37MP0005670_abnormal_white_adipose1.24067735
38MP0002108_abnormal_muscle_morphology1.10381911
39MP0005423_abnormal_somatic_nervous1.05799924
40MP0002234_abnormal_pharynx_morphology1.05689850
41MP0000343_altered_response_to1.03180881
42MP0003879_abnormal_hair_cell1.02922843
43MP0005375_adipose_tissue_phenotype1.00788103
44MP0000266_abnormal_heart_morphology1.00139899
45MP0004185_abnormal_adipocyte_glucose0.93339004
46MP0005165_increased_susceptibility_to0.92848468
47MP0000013_abnormal_adipose_tissue0.92517717
48MP0006035_abnormal_mitochondrial_morpho0.92270990
49MP0000733_abnormal_muscle_development0.92089151
50MP0003279_aneurysm0.89692856
51MP0001661_extended_life_span0.89091213
52MP0003567_abnormal_fetal_cardiomyocyte0.88278561
53MP0005623_abnormal_meninges_morphology0.87894329
54MP0002909_abnormal_adrenal_gland0.86721938
55MP0010368_abnormal_lymphatic_system0.80730157
56MP0002734_abnormal_mechanical_nocicepti0.77524175
57MP0004859_abnormal_synaptic_plasticity0.75899648
58MP0005266_abnormal_metabolism0.75646861
59MP0000230_abnormal_systemic_arterial0.72532690
60MP0000003_abnormal_adipose_tissue0.69675903
61MP0002971_abnormal_brown_adipose0.66938172
62MP0002128_abnormal_blood_circulation0.66092255
63MP0004043_abnormal_pH_regulation0.63436559
64MP0003880_abnormal_central_pattern0.63031240
65MP0008569_lethality_at_weaning0.62906820
66MP0008961_abnormal_basal_metabolism0.62303348
67MP0004270_analgesia0.61297169
68MP0009780_abnormal_chondrocyte_physiolo0.59733209
69MP0003566_abnormal_cell_adhesion0.56040383
70MP0002249_abnormal_larynx_morphology0.54507517
71MP0002063_abnormal_learning/memory/cond0.53620221
72MP0002822_catalepsy0.53257724
73MP0004147_increased_porphyrin_level0.53168320
74MP0003045_fibrosis0.52604236
75MP0004924_abnormal_behavior0.50302181
76MP0005386_behavior/neurological_phenoty0.50302181
77MP0001346_abnormal_lacrimal_gland0.48008103
78MP0000767_abnormal_smooth_muscle0.47633393
79MP0002078_abnormal_glucose_homeostasis0.47399716
80MP0003705_abnormal_hypodermis_morpholog0.46721056
81MP0001958_emphysema0.45492834
82MP0003329_amyloid_beta_deposits0.45081506
83MP0005535_abnormal_body_temperature0.45057475
84MP0009046_muscle_twitch0.44958719
85MP0001502_abnormal_circadian_rhythm0.44745159
86MP0001486_abnormal_startle_reflex0.42257065
87MP0001879_abnormal_lymphatic_vessel0.41450804
88MP0005187_abnormal_penis_morphology0.41309256
89MP0003635_abnormal_synaptic_transmissio0.41212343
90MP0001501_abnormal_sleep_pattern0.39934897
91MP0006276_abnormal_autonomic_nervous0.38577095
92MP0004134_abnormal_chest_morphology0.37750582
93MP0010030_abnormal_orbit_morphology0.37345521
94MP0000762_abnormal_tongue_morphology0.36927236
95MP0002638_abnormal_pupillary_reflex0.35805486
96MP0005319_abnormal_enzyme/_coenzyme0.35512778
97MP0002272_abnormal_nervous_system0.35396638
98MP0002925_abnormal_cardiovascular_devel0.35167609
99MP0003948_abnormal_gas_homeostasis0.35024064
100MP0001299_abnormal_eye_distance/0.34572476
101MP0005584_abnormal_enzyme/coenzyme_acti0.34227979
102MP0005167_abnormal_blood-brain_barrier0.33889858
103MP0005166_decreased_susceptibility_to0.33793518
104MP0002572_abnormal_emotion/affect_behav0.33302603
105MP0004858_abnormal_nervous_system0.32806893
106MP0005409_darkened_coat_color0.32768781
107MP0001440_abnormal_grooming_behavior0.32203563
108MP0005503_abnormal_tendon_morphology0.32023618
109MP0002114_abnormal_axial_skeleton0.31607970
110MP0008874_decreased_physiological_sensi0.31244763
111MP0005334_abnormal_fat_pad0.29190692
112MP0002064_seizures0.28915264
113MP0009745_abnormal_behavioral_response0.28336639
114MP0003633_abnormal_nervous_system0.28194749
115MP0001784_abnormal_fluid_regulation0.28104348
116MP0002735_abnormal_chemical_nociception0.27177771
117MP0002067_abnormal_sensory_capabilities0.26893183
118MP0001614_abnormal_blood_vessel0.24635603
119MP0005595_abnormal_vascular_smooth0.23440975
120MP0002066_abnormal_motor_capabilities/c0.22975093
121MP0005452_abnormal_adipose_tissue0.21385212
122MP0005451_abnormal_body_composition0.21368369
123MP0004272_abnormal_basement_membrane0.21068997
124MP0005275_abnormal_skin_tensile0.20837484

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.63157822
2Calf muscle hypertrophy (HP:0008981)6.63504218
3Exercise-induced myalgia (HP:0003738)6.39536987
4Muscle hypertrophy of the lower extremities (HP:0008968)6.31009997
5Muscle fiber splitting (HP:0003555)6.10069135
6Exercise-induced muscle cramps (HP:0003710)6.04497704
7Ventricular tachycardia (HP:0004756)5.98826570
8Abnormality of the calf musculature (HP:0001430)5.53718913
9Atrial fibrillation (HP:0005110)5.52209027
10Hyporeflexia of lower limbs (HP:0002600)5.36386092
11Primary atrial arrhythmia (HP:0001692)5.16896262
12Supraventricular tachycardia (HP:0004755)4.97842746
13Subaortic stenosis (HP:0001682)4.88738608
14Abnormality of the left ventricular outflow tract (HP:0011103)4.88738608
15Supraventricular arrhythmia (HP:0005115)4.87081555
16Myoglobinuria (HP:0002913)4.73932120
17Lipoatrophy (HP:0100578)4.70199739
18Muscle fiber inclusion bodies (HP:0100299)4.67153678
19EMG: myopathic abnormalities (HP:0003458)4.66111657
20Syncope (HP:0001279)4.56797989
21Right ventricular cardiomyopathy (HP:0011663)4.53272184
22Bundle branch block (HP:0011710)4.50528098
23Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.50430248
24Difficulty running (HP:0009046)4.25830141
25Increased connective tissue (HP:0009025)4.22433214
26Ulnar deviation of the wrist (HP:0003049)4.21592030
27Prolonged QT interval (HP:0001657)4.17768300
28Type 1 muscle fiber predominance (HP:0003803)4.14736855
29Dilated cardiomyopathy (HP:0001644)4.00477458
30Myotonia (HP:0002486)3.88776624
31Ventricular arrhythmia (HP:0004308)3.84689799
32Nemaline bodies (HP:0003798)3.83310832
33Asymmetric septal hypertrophy (HP:0001670)3.82764907
34Palpitations (HP:0001962)3.81071690
35Heart block (HP:0012722)3.71617425
36Ventricular fibrillation (HP:0001663)3.70369879
37Calcaneovalgus deformity (HP:0001848)3.59389264
38Abnormal atrioventricular conduction (HP:0005150)3.52175546
39Atrioventricular block (HP:0001678)3.51404570
40Rhabdomyolysis (HP:0003201)3.50122388
41Difficulty climbing stairs (HP:0003551)3.40482131
42Deformed tarsal bones (HP:0008119)3.16896178
43Malignant hyperthermia (HP:0002047)3.12247725
44Absent phalangeal crease (HP:0006109)3.11434969
45Abnormal EKG (HP:0003115)3.10784199
46Increased variability in muscle fiber diameter (HP:0003557)3.05438348
47Muscle stiffness (HP:0003552)3.01258511
48Abnormality of skeletal muscle fiber size (HP:0012084)2.98082057
49Neck muscle weakness (HP:0000467)2.86725145
50Distal lower limb muscle weakness (HP:0009053)2.77149045
51Areflexia of lower limbs (HP:0002522)2.75687726
52Left ventricular hypertrophy (HP:0001712)2.70222098
53Fetal akinesia sequence (HP:0001989)2.68377629
54Limb-girdle muscle atrophy (HP:0003797)2.60682590
55Abnormal finger flexion creases (HP:0006143)2.53647331
56Distal arthrogryposis (HP:0005684)2.49774436
57Weak cry (HP:0001612)2.45336526
58Distal lower limb amyotrophy (HP:0008944)2.44186594
59Rimmed vacuoles (HP:0003805)2.41516882
60Gowers sign (HP:0003391)2.41077579
61Myopathic facies (HP:0002058)2.39291957
62Slender build (HP:0001533)2.39258833
63Mildly elevated creatine phosphokinase (HP:0008180)2.39115955
64Testicular atrophy (HP:0000029)2.37545066
65Spinal rigidity (HP:0003306)2.36195763
66EMG: neuropathic changes (HP:0003445)2.32346049
67Palmoplantar keratoderma (HP:0000982)2.29225373
68Ketoacidosis (HP:0001993)2.27294705
69Muscular dystrophy (HP:0003560)2.27275118
70Dysmetric saccades (HP:0000641)2.23762120
71Facial diplegia (HP:0001349)2.23620697
72Round ear (HP:0100830)2.23197689
73Abnormality of the foot musculature (HP:0001436)2.20116070
74Hypoplastic ischia (HP:0003175)2.19980257
75Abnormal mitochondria in muscle tissue (HP:0008316)2.18699515
76Hepatic necrosis (HP:0002605)2.18649306
77Generalized muscle weakness (HP:0003324)2.16870743
78Foot dorsiflexor weakness (HP:0009027)2.12171651
79Abnormality of the calcaneus (HP:0008364)2.12075495
80Hyperkalemia (HP:0002153)2.11732312
81Scapular winging (HP:0003691)2.10640163
82Acute necrotizing encephalopathy (HP:0006965)2.09345390
83Waddling gait (HP:0002515)2.08808354
84Lower limb amyotrophy (HP:0007210)2.07271614
85Frequent falls (HP:0002359)2.05667695
86Proximal amyotrophy (HP:0007126)2.05521329
87Centrally nucleated skeletal muscle fibers (HP:0003687)2.04612690
88Sudden cardiac death (HP:0001645)1.99758485
89Popliteal pterygium (HP:0009756)1.93765151
90Hepatocellular necrosis (HP:0001404)1.91853015
91Abnormality of the shoulder girdle musculature (HP:0001435)1.91534034
92Abnormality of the ischium (HP:0003174)1.91404055
93Pheochromocytoma (HP:0002666)1.90130119
94Progressive muscle weakness (HP:0003323)1.89346448
95Increased muscle lipid content (HP:0009058)1.89009364
96Hip contracture (HP:0003273)1.88940682
97Respiratory insufficiency due to muscle weakness (HP:0002747)1.88139073
98Hypoglycemic coma (HP:0001325)1.86596560
99Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.83020178
100Abnormality of the neuromuscular junction (HP:0003398)1.82976012
101Fatigable weakness (HP:0003473)1.82976012
102Congestive heart failure (HP:0001635)1.79659176
103Ragged-red muscle fibers (HP:0003200)1.77830877
104Bulbar palsy (HP:0001283)1.75722074
105Acute encephalopathy (HP:0006846)1.75473301
106Conjunctival hamartoma (HP:0100780)1.73470493
107Progressive macrocephaly (HP:0004481)1.73379102
108Large for gestational age (HP:0001520)1.72092014
109Abnormality of fatty-acid metabolism (HP:0004359)1.71513971
110Abnormality of alanine metabolism (HP:0010916)1.71432618
111Hyperalaninemia (HP:0003348)1.71432618
112Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.71432618
113Limb-girdle muscle weakness (HP:0003325)1.70546266
114Limited hip movement (HP:0008800)1.70493376
115Central scotoma (HP:0000603)1.70069795
116Mitochondrial inheritance (HP:0001427)1.69537767
117Exercise intolerance (HP:0003546)1.69392353
118Nonprogressive disorder (HP:0003680)1.64393847
119Type 2 muscle fiber atrophy (HP:0003554)1.54618870
120Easy fatigability (HP:0003388)1.49692377
121Metatarsus adductus (HP:0001840)1.49060674
122Muscle fiber atrophy (HP:0100295)1.47307824
123Steppage gait (HP:0003376)1.46379830
124Ankle clonus (HP:0011448)1.45104371
125Generalized amyotrophy (HP:0003700)1.42443988
126Long clavicles (HP:0000890)1.40116116
127Abnormality of the hip-girdle musculature (HP:0001445)1.39584767
128Abnormality of the musculature of the pelvis (HP:0001469)1.39584767

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN5.86059740
2TTN5.83140717
3PHKG14.29599024
4PHKG24.29599024
5LMTK23.41927740
6DMPK3.12563632
7PDK43.03778866
8PDK33.03778866
9MUSK2.83509752
10MYLK2.82308954
11TRIB32.50652914
12PKN22.37358360
13PINK12.31994121
14NEK12.28928072
15PIK3CA1.90410876
16PDK21.85303401
17BCKDK1.80564066
18MARK11.66590969
19TIE11.62503715
20STK241.46328939
21MAP3K71.33773388
22GRK71.27401171
23CAMK2D1.25954792
24PAK31.19822222
25EPHA41.18406650
26PRKD11.17334052
27MAPK121.16353607
28MOS1.13679922
29LIMK11.11291789
30ZAK1.10148543
31EEF2K1.08965750
32STK381.07173185
33ILK1.03056405
34INSRR0.99730293
35PIK3CG0.99290065
36CDC42BPA0.98654572
37MAP2K30.97717400
38ROCK10.96833161
39RIPK10.96632534
40MAP3K130.89520583
41NME10.86920111
42PRKAA10.86585933
43WNK10.84810280
44MAP2K40.84221487
45MAP3K50.79077226
46CCNB10.78571670
47MAPKAPK30.77896704
48PRPF4B0.76987455
49PRKAA20.75488270
50WNK40.73411161
51PKN10.71833619
52CAMK40.71124867
53MAP3K40.70168778
54ARAF0.69890811
55DYRK1B0.69313571
56CAMK2A0.69225080
57CAMK2B0.69049130
58TRPM70.67910419
59UHMK10.65424570
60PAK60.65274003
61CAMK10.64202553
62PRKD30.63781706
63DAPK30.63090737
64MAPK40.62775663
65EPHB10.60738609
66PDGFRA0.60185767
67ROCK20.56258552
68MAP2K10.56009390
69PTK2B0.52958631
70CAMK2G0.49955700
71PRKACB0.49745329
72AKT20.48896317
73PRKCH0.48764436
74STK38L0.48700538
75MAP3K90.48125623
76MAP3K30.47593271
77PDPK10.47214550
78SGK30.45239712
79MAPK100.42655626
80PRKCE0.41809835
81TAOK10.41803092
82RPS6KC10.41517082
83RPS6KL10.41517082
84MAPK110.41469682
85STK40.41025409
86PDK10.40801334
87PRKACA0.40016398
88LATS20.39468836
89SIK10.38808158
90ICK0.37843535
91MAP3K110.37706519
92FLT30.36799371
93MAP3K60.35790491
94PRKACG0.35714944
95SGK10.35648941
96CDK50.34681400
97NTRK10.34297324
98NTRK30.33500320
99RPS6KA60.33067118
100SGK4940.32931948
101SGK2230.32931948
102GRK50.32357421
103RET0.32211863
104DAPK20.31432509
105MAP2K60.31277493
106TGFBR20.31135964
107RPS6KA30.29653495
108TESK10.28687401
109PRKG10.28224720
110MAPK130.27433961
111NEK90.26845435
112CAMK1G0.25679837
113FER0.25091969
114CAMKK10.25065257
115MAP3K10.24378395
116SGK20.24335439
117STK110.24185757
118TAOK20.22795262
119NTRK20.21904750
120JAK10.21358636
121PTK60.21152280
122MARK20.21041689
123TNK20.20896812
124RPS6KA20.19996072
125MAPK70.19778541
126RAF10.19672933
127BRAF0.19434380
128KSR20.19405268
129CDK190.17714252
130RPS6KA10.17014213
131STK390.15376143
132MTOR0.12971904

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.27513384
2Cardiac muscle contraction_Homo sapiens_hsa042604.16622473
3Dilated cardiomyopathy_Homo sapiens_hsa054143.97449828
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.89351311
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.85177085
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.19059769
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.79738610
8Propanoate metabolism_Homo sapiens_hsa006402.62993624
9Parkinsons disease_Homo sapiens_hsa050122.40707721
10Oxidative phosphorylation_Homo sapiens_hsa001902.30253280
11Fatty acid degradation_Homo sapiens_hsa000712.28057602
12Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.17028351
13Carbon metabolism_Homo sapiens_hsa012002.04460545
14Alzheimers disease_Homo sapiens_hsa050101.89208934
15Fatty acid metabolism_Homo sapiens_hsa012121.76334074
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68134927
17Viral myocarditis_Homo sapiens_hsa054161.63571923
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.59233942
19Pyruvate metabolism_Homo sapiens_hsa006201.43620091
20Huntingtons disease_Homo sapiens_hsa050161.39427365
21Pentose phosphate pathway_Homo sapiens_hsa000301.31352832
22Calcium signaling pathway_Homo sapiens_hsa040201.25405023
23cGMP-PKG signaling pathway_Homo sapiens_hsa040221.23188068
24Oxytocin signaling pathway_Homo sapiens_hsa049211.22062562
25Glucagon signaling pathway_Homo sapiens_hsa049221.21493084
26Insulin resistance_Homo sapiens_hsa049311.15788976
27Insulin signaling pathway_Homo sapiens_hsa049101.10355419
28Adipocytokine signaling pathway_Homo sapiens_hsa049201.09789915
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06084809
30Type II diabetes mellitus_Homo sapiens_hsa049301.05553818
31Butanoate metabolism_Homo sapiens_hsa006501.04755348
32Insulin secretion_Homo sapiens_hsa049111.00525959
33Circadian entrainment_Homo sapiens_hsa047130.98870082
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97680283
35Starch and sucrose metabolism_Homo sapiens_hsa005000.97375819
36Gastric acid secretion_Homo sapiens_hsa049710.94306842
37Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88824845
38Biosynthesis of amino acids_Homo sapiens_hsa012300.87964037
39Renin secretion_Homo sapiens_hsa049240.87052774
40Vascular smooth muscle contraction_Homo sapiens_hsa042700.86559032
41PPAR signaling pathway_Homo sapiens_hsa033200.81681605
42AMPK signaling pathway_Homo sapiens_hsa041520.79200929
43Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78331352
44Fatty acid elongation_Homo sapiens_hsa000620.78273857
45cAMP signaling pathway_Homo sapiens_hsa040240.76628331
46Focal adhesion_Homo sapiens_hsa045100.73648957
47Arginine biosynthesis_Homo sapiens_hsa002200.73525157
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71774640
49Olfactory transduction_Homo sapiens_hsa047400.70526948
50HIF-1 signaling pathway_Homo sapiens_hsa040660.70352520
51Glioma_Homo sapiens_hsa052140.68950261
52Melanogenesis_Homo sapiens_hsa049160.67948588
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64959330
54Tight junction_Homo sapiens_hsa045300.63227244
55Lysine degradation_Homo sapiens_hsa003100.63077138
56Circadian rhythm_Homo sapiens_hsa047100.62925115
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62462379
58Fatty acid biosynthesis_Homo sapiens_hsa000610.61061241
59GnRH signaling pathway_Homo sapiens_hsa049120.60036589
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59769387
61Cholinergic synapse_Homo sapiens_hsa047250.59502131
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58193054
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56591479
64Salivary secretion_Homo sapiens_hsa049700.56339957
65Long-term depression_Homo sapiens_hsa047300.55925237
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55736210
67Long-term potentiation_Homo sapiens_hsa047200.54379739
68GABAergic synapse_Homo sapiens_hsa047270.53082735
69beta-Alanine metabolism_Homo sapiens_hsa004100.51803702
70Taste transduction_Homo sapiens_hsa047420.51471426
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50106425
72Morphine addiction_Homo sapiens_hsa050320.50081183
73Galactose metabolism_Homo sapiens_hsa000520.49054762
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.48835255
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.47712710
76Arginine and proline metabolism_Homo sapiens_hsa003300.46427104
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43681628
78Tryptophan metabolism_Homo sapiens_hsa003800.43139549
79Fructose and mannose metabolism_Homo sapiens_hsa000510.42261774
80Glutamatergic synapse_Homo sapiens_hsa047240.41636924
81Gap junction_Homo sapiens_hsa045400.39478466
82Dorso-ventral axis formation_Homo sapiens_hsa043200.39128123
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.37763432
84Bile secretion_Homo sapiens_hsa049760.36173480
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36119063
86Amphetamine addiction_Homo sapiens_hsa050310.36000618
87FoxO signaling pathway_Homo sapiens_hsa040680.35624039
88Dopaminergic synapse_Homo sapiens_hsa047280.35147027
89Amoebiasis_Homo sapiens_hsa051460.34857967
90Thyroid hormone synthesis_Homo sapiens_hsa049180.34677461
91ECM-receptor interaction_Homo sapiens_hsa045120.34345299
92Nicotine addiction_Homo sapiens_hsa050330.34166254
93Cocaine addiction_Homo sapiens_hsa050300.33812170
94Pancreatic secretion_Homo sapiens_hsa049720.33376609
95mTOR signaling pathway_Homo sapiens_hsa041500.32777001
96MAPK signaling pathway_Homo sapiens_hsa040100.32208522
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.31819419
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31512455
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31093240
100VEGF signaling pathway_Homo sapiens_hsa043700.30773258
101Oocyte meiosis_Homo sapiens_hsa041140.29696672
102Adherens junction_Homo sapiens_hsa045200.29499815
103ErbB signaling pathway_Homo sapiens_hsa040120.28691445
104Phenylalanine metabolism_Homo sapiens_hsa003600.28413072
105Renal cell carcinoma_Homo sapiens_hsa052110.26828559
106Nitrogen metabolism_Homo sapiens_hsa009100.26586473
107Ovarian steroidogenesis_Homo sapiens_hsa049130.26261961
108Platelet activation_Homo sapiens_hsa046110.24951348
109Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24616217
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23703070
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23694134
112Estrogen signaling pathway_Homo sapiens_hsa049150.23615475
113Proteoglycans in cancer_Homo sapiens_hsa052050.23581419
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.22661182
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21735448
116Synaptic vesicle cycle_Homo sapiens_hsa047210.21442012

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