

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | sarcomere organization (GO:0045214) | 8.49655443 |
| 2 | cardiac myofibril assembly (GO:0055003) | 7.54388516 |
| 3 | muscle filament sliding (GO:0030049) | 7.40147036 |
| 4 | actin-myosin filament sliding (GO:0033275) | 7.40147036 |
| 5 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 7.34215318 |
| 6 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 7.09486334 |
| 7 | myofibril assembly (GO:0030239) | 7.09083153 |
| 8 | plasma membrane repair (GO:0001778) | 6.87534911 |
| 9 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 6.71795556 |
| 10 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 6.69988155 |
| 11 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 6.64304311 |
| 12 | regulation of skeletal muscle contraction (GO:0014819) | 6.44193180 |
| 13 | cardiac muscle contraction (GO:0060048) | 6.29446785 |
| 14 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 6.13695786 |
| 15 | actin-mediated cell contraction (GO:0070252) | 6.12892802 |
| 16 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 5.98214470 |
| 17 | regulation of relaxation of muscle (GO:1901077) | 5.92226194 |
| 18 | regulation of actin filament-based movement (GO:1903115) | 5.68304708 |
| 19 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 5.65137818 |
| 20 | cardiac muscle cell development (GO:0055013) | 5.64482158 |
| 21 | tricarboxylic acid cycle (GO:0006099) | 5.59725209 |
| 22 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 5.57083146 |
| 23 | response to muscle activity (GO:0014850) | 5.47821081 |
| 24 | striated muscle contraction (GO:0006941) | 5.45849180 |
| 25 | actomyosin structure organization (GO:0031032) | 5.44187763 |
| 26 | regulation of cell communication by electrical coupling (GO:0010649) | 5.41006582 |
| 27 | skeletal muscle fiber development (GO:0048741) | 5.33522671 |
| 28 | cardiac cell development (GO:0055006) | 5.27839670 |
| 29 | ventricular cardiac muscle cell action potential (GO:0086005) | 5.26458923 |
| 30 | cardiac muscle hypertrophy (GO:0003300) | 5.22360288 |
| 31 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 5.11032055 |
| 32 | adult heart development (GO:0007512) | 5.05741619 |
| 33 | striated muscle hypertrophy (GO:0014897) | 5.01255070 |
| 34 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 4.99751419 |
| 35 | carnitine shuttle (GO:0006853) | 4.92529149 |
| 36 | cardiac muscle tissue morphogenesis (GO:0055008) | 4.89330033 |
| 37 | regulation of striated muscle contraction (GO:0006942) | 4.84091167 |
| 38 | myotube cell development (GO:0014904) | 4.79447660 |
| 39 | regulation of membrane repolarization (GO:0060306) | 4.79407235 |
| 40 | regulation of sarcomere organization (GO:0060297) | 4.74061836 |
| 41 | actin filament-based movement (GO:0030048) | 4.67455049 |
| 42 | cell communication involved in cardiac conduction (GO:0086065) | 4.67054826 |
| 43 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 4.58069646 |
| 44 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 4.56405168 |
| 45 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 4.53423803 |
| 46 | skeletal muscle contraction (GO:0003009) | 4.51817090 |
| 47 | muscle tissue morphogenesis (GO:0060415) | 4.48320276 |
| 48 | cell communication by electrical coupling (GO:0010644) | 4.45170945 |
| 49 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 4.44898769 |
| 50 | muscle hypertrophy (GO:0014896) | 4.42829735 |
| 51 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 4.24093378 |
| 52 | heart trabecula formation (GO:0060347) | 4.22905944 |
| 53 | glycogen catabolic process (GO:0005980) | 4.22553283 |
| 54 | regulation of the force of heart contraction (GO:0002026) | 4.21249378 |
| 55 | fatty acid transmembrane transport (GO:1902001) | 4.21186133 |
| 56 | regulation of cofactor metabolic process (GO:0051193) | 4.15787745 |
| 57 | regulation of coenzyme metabolic process (GO:0051196) | 4.15787745 |
| 58 | skeletal muscle tissue development (GO:0007519) | 4.07288622 |
| 59 | heart contraction (GO:0060047) | 4.05187026 |
| 60 | heart process (GO:0003015) | 4.05187026 |
| 61 | cardiac muscle cell action potential (GO:0086001) | 4.04879840 |
| 62 | regulation of cardiac muscle contraction (GO:0055117) | 4.04619582 |
| 63 | cardiac muscle cell action potential involved in contraction (GO:0086002) | 4.00906742 |
| 64 | regulation of cardiac muscle cell contraction (GO:0086004) | 3.99863482 |
| 65 | glucan catabolic process (GO:0009251) | 3.94168014 |
| 66 | regulation of calcium ion transmembrane transport (GO:1903169) | 3.86302066 |
| 67 | regulation of calcium ion transmembrane transporter activity (GO:1901019) | 3.86302066 |
| 68 | cardiac muscle adaptation (GO:0014887) | 3.85491990 |
| 69 | cardiac muscle hypertrophy in response to stress (GO:0014898) | 3.85491990 |
| 70 | muscle hypertrophy in response to stress (GO:0003299) | 3.85491990 |
| 71 | positive regulation of myotube differentiation (GO:0010831) | 3.84705155 |
| 72 | muscle contraction (GO:0006936) | 3.84452889 |
| 73 | negative regulation of potassium ion transport (GO:0043267) | 3.82984445 |
| 74 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.79166202 |
| 75 | regulation of heart rate (GO:0002027) | 3.78435446 |
| 76 | neuronal action potential propagation (GO:0019227) | 3.75017287 |
| 77 | glucan biosynthetic process (GO:0009250) | 3.74130459 |
| 78 | glycogen biosynthetic process (GO:0005978) | 3.74130459 |
| 79 | muscle cell fate commitment (GO:0042693) | 3.72030791 |
| 80 | relaxation of cardiac muscle (GO:0055119) | 3.71834448 |
| 81 | creatine metabolic process (GO:0006600) | 3.69450800 |
| 82 | negative regulation of protein localization to cell surface (GO:2000009) | 3.68227213 |
| 83 | cellular polysaccharide catabolic process (GO:0044247) | 3.67781064 |
| 84 | positive regulation of cation channel activity (GO:2001259) | 3.67553856 |
| 85 | cardiac conduction (GO:0061337) | 3.67281762 |
| 86 | response to inactivity (GO:0014854) | 3.63560416 |
| 87 | carnitine transmembrane transport (GO:1902603) | 3.63309803 |
| 88 | NADH metabolic process (GO:0006734) | 3.61334301 |
| 89 | striated muscle cell development (GO:0055002) | 3.61041878 |
| 90 | muscle cell cellular homeostasis (GO:0046716) | 3.59406095 |
| 91 | muscle system process (GO:0003012) | 3.57992385 |
| 92 | striated muscle adaptation (GO:0014888) | 3.57343237 |
| 93 | regulation of heart contraction (GO:0008016) | 3.53609260 |
| 94 | regulation of heart rate by cardiac conduction (GO:0086091) | 3.50713412 |
| 95 | muscle organ development (GO:0007517) | 3.49700954 |
| 96 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.49345246 |
| 97 | negative regulation of calcium ion transmembrane transporter activity (GO:1901020) | 3.48863368 |
| 98 | negative regulation of calcium ion transmembrane transport (GO:1903170) | 3.48863368 |
| 99 | detection of calcium ion (GO:0005513) | 3.48035913 |
| 100 | muscle structure development (GO:0061061) | 3.46280929 |
| 101 | skeletal muscle adaptation (GO:0043501) | 3.46125432 |
| 102 | regulation of skeletal muscle cell differentiation (GO:2001014) | 3.43150827 |
| 103 | muscle adaptation (GO:0043500) | 3.41258608 |
| 104 | negative regulation of cardiac muscle cell apoptotic process (GO:0010667) | 3.38193298 |
| 105 | regulation of ATP catabolic process (GO:1903289) | 3.38040360 |
| 106 | regulation of ATPase activity (GO:0043462) | 3.38040360 |
| 107 | relaxation of muscle (GO:0090075) | 3.36024475 |
| 108 | regulation of sulfur metabolic process (GO:0042762) | 3.35002548 |
| 109 | positive regulation of heart rate (GO:0010460) | 3.31514687 |
| 110 | 2-oxoglutarate metabolic process (GO:0006103) | 3.29912993 |
| 111 | amino-acid betaine transport (GO:0015838) | 3.27879503 |
| 112 | carnitine transport (GO:0015879) | 3.27879503 |
| 113 | polysaccharide catabolic process (GO:0000272) | 3.27627266 |
| 114 | oxygen transport (GO:0015671) | 3.26567461 |
| 115 | regulation of muscle contraction (GO:0006937) | 3.26015423 |
| 116 | striated muscle atrophy (GO:0014891) | 3.25297892 |
| 117 | positive regulation of heart contraction (GO:0045823) | 3.23184022 |
| 118 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 3.20259657 |
| 119 | skeletal muscle tissue regeneration (GO:0043403) | 3.18525407 |
| 120 | muscle cell development (GO:0055001) | 3.18202019 |
| 121 | regulation of muscle system process (GO:0090257) | 3.17611090 |
| 122 | negative regulation of striated muscle cell apoptotic process (GO:0010664) | 3.16328941 |
| 123 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.15822202 |
| 124 | muscle fiber development (GO:0048747) | 3.14683869 |
| 125 | regulation of calcineurin-NFAT signaling cascade (GO:0070884) | 3.10369725 |
| 126 | regulation of cation channel activity (GO:2001257) | 3.10128305 |
| 127 | gluconeogenesis (GO:0006094) | 3.10038936 |
| 128 | neuromuscular synaptic transmission (GO:0007274) | 3.08547152 |
| 129 | regulation of myoblast differentiation (GO:0045661) | 3.06041872 |
| 130 | myoblast fusion (GO:0007520) | 3.03608265 |
| 131 | glycogen metabolic process (GO:0005977) | 3.03048041 |
| 132 | striated muscle tissue development (GO:0014706) | 2.99313751 |
| 133 | glucan metabolic process (GO:0044042) | 2.96051126 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 4.21848952 |
| 2 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.99059167 |
| 3 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 3.92755652 |
| 4 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 3.53219632 |
| 5 | * TBX20_22080862_ChIP-Seq_HEART_Mouse | 3.23770799 |
| 6 | * TBX20_22328084_ChIP-Seq_HEART_Mouse | 3.23770799 |
| 7 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.84805466 |
| 8 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 2.82237942 |
| 9 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.62339854 |
| 10 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 2.31048584 |
| 11 | ZNF263_19887448_ChIP-Seq_K562_Human | 2.27975896 |
| 12 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.21989207 |
| 13 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.13291232 |
| 14 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.11265935 |
| 15 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.09940026 |
| 16 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 2.05037431 |
| 17 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.00955734 |
| 18 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.98387127 |
| 19 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.94351973 |
| 20 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.89852689 |
| 21 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 1.71565429 |
| 22 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.71084459 |
| 23 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.64595825 |
| 24 | GATA4_21415370_ChIP-Seq_HL-1_Mouse | 1.64168732 |
| 25 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.59177926 |
| 26 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.53487270 |
| 27 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.49779554 |
| 28 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.49779554 |
| 29 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.49430397 |
| 30 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.48719605 |
| 31 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 1.47412127 |
| 32 | * MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.46749225 |
| 33 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.43914036 |
| 34 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.43835195 |
| 35 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.42637866 |
| 36 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.36672210 |
| 37 | * KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.36588517 |
| 38 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.32914185 |
| 39 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.32808683 |
| 40 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.32713788 |
| 41 | SMC3_22415368_ChIP-Seq_MEFs_Mouse | 1.30542162 |
| 42 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.29573468 |
| 43 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.29079770 |
| 44 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.26790453 |
| 45 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.24251164 |
| 46 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.21244871 |
| 47 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.20957442 |
| 48 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.17936416 |
| 49 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.17033166 |
| 50 | STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 1.16885911 |
| 51 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.14904891 |
| 52 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 1.14478423 |
| 53 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.14038256 |
| 54 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.13157060 |
| 55 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.12230673 |
| 56 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.12050332 |
| 57 | * CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.11869459 |
| 58 | * SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.11478169 |
| 59 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.11349753 |
| 60 | * SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.09588977 |
| 61 | MYC_27129775_Chip-Seq_CORNEA_Mouse | 1.09556588 |
| 62 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.07518790 |
| 63 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.06387367 |
| 64 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 1.06037655 |
| 65 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.05463652 |
| 66 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.05409838 |
| 67 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.05167796 |
| 68 | * SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.04529661 |
| 69 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.04494928 |
| 70 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.04489302 |
| 71 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.04349531 |
| 72 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.04185990 |
| 73 | * TCF7_22412390_ChIP-Seq_EML_Mouse | 1.03352585 |
| 74 | SA1_27219007_Chip-Seq_Bcells_Human | 1.03005626 |
| 75 | * KDM2B_26808549_Chip-Seq_DND41_Human | 1.02929498 |
| 76 | * KDM2B_26808549_Chip-Seq_K562_Human | 1.01805642 |
| 77 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.01689925 |
| 78 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.01036338 |
| 79 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.00550509 |
| 80 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 1.00534243 |
| 81 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.99853874 |
| 82 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.98854446 |
| 83 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 0.98615088 |
| 84 | * TP63_22573176_ChIP-Seq_HFKS_Human | 0.98366598 |
| 85 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 0.97830973 |
| 86 | * BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.96954988 |
| 87 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.95001558 |
| 88 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.94989305 |
| 89 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.94260237 |
| 90 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.94067438 |
| 91 | SMC1_22415368_ChIP-Seq_MEFs_Mouse | 0.93337217 |
| 92 | OCT4_19829295_ChIP-Seq_ESCs_Human | 0.93310715 |
| 93 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.92624077 |
| 94 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.91519982 |
| 95 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.91385628 |
| 96 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 0.91325063 |
| 97 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 0.91244023 |
| 98 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.91016275 |
| 99 | GATA1_19941826_ChIP-Seq_K562_Human | 0.90554904 |
| 100 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 0.89864703 |
| 101 | * TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.89624143 |
| 102 | * SA1_27219007_Chip-Seq_ERYTHROID_Human | 0.89324252 |
| 103 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 0.88829496 |
| 104 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.88501748 |
| 105 | GBX2_23144817_ChIP-Seq_PC3_Human | 0.88084558 |
| 106 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 0.87336872 |
| 107 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.86704147 |
| 108 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.86185800 |
| 109 | AR_19668381_ChIP-Seq_PC3_Human | 0.85231577 |
| 110 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 0.84219110 |
| 111 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.84169214 |
| 112 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 0.83898403 |
| 113 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.83812199 |
| 114 | AR_21572438_ChIP-Seq_LNCaP_Human | 0.83709938 |
| 115 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 0.82957989 |
| 116 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 0.82553068 |
| 117 | CLOCK_20551151_ChIP-Seq_293T_Human | 0.82131562 |
| 118 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 0.81609634 |
| 119 | * SMAD4_21799915_ChIP-Seq_A2780_Human | 0.81068856 |
| 120 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 0.80192941 |
| 121 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.80088291 |
| 122 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.79638849 |
| 123 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.79531766 |
| 124 | P68_20966046_ChIP-Seq_HELA_Human | 0.79441262 |
| 125 | CJUN_26792858_Chip-Seq_BT549_Human | 0.79211280 |
| 126 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.78956132 |
| 127 | SPI1_23127762_ChIP-Seq_K562_Human | 0.78419279 |
| 128 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.78241495 |
| 129 | * REST_18959480_ChIP-ChIP_MESCs_Mouse | 0.77874247 |
| 130 | TP53_16413492_ChIP-PET_HCT116_Human | 0.77850082 |
| 131 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.77342568 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002837_dystrophic_cardiac_calcinosis | 6.47379907 |
| 2 | MP0003646_muscle_fatigue | 5.79274952 |
| 3 | MP0000751_myopathy | 5.64928146 |
| 4 | MP0004084_abnormal_cardiac_muscle | 5.06231687 |
| 5 | MP0004215_abnormal_myocardial_fiber | 4.54197910 |
| 6 | MP0000749_muscle_degeneration | 4.31553433 |
| 7 | MP0004036_abnormal_muscle_relaxation | 4.11933382 |
| 8 | MP0005330_cardiomyopathy | 3.61135592 |
| 9 | MP0004145_abnormal_muscle_electrophysio | 3.28796713 |
| 10 | MP0004087_abnormal_muscle_fiber | 3.18922079 |
| 11 | MP0002972_abnormal_cardiac_muscle | 2.93698827 |
| 12 | MP0000750_abnormal_muscle_regeneration | 2.91055663 |
| 13 | MP0002106_abnormal_muscle_physiology | 2.82305915 |
| 14 | MP0003137_abnormal_impulse_conducting | 2.79250652 |
| 15 | MP0005620_abnormal_muscle_contractility | 2.78008276 |
| 16 | MP0008775_abnormal_heart_ventricle | 2.61753418 |
| 17 | MP0004130_abnormal_muscle_cell | 2.59213811 |
| 18 | MP0002269_muscular_atrophy | 2.51999746 |
| 19 | MP0000747_muscle_weakness | 2.45266337 |
| 20 | MP0004484_altered_response_of | 2.43998299 |
| 21 | MP0010630_abnormal_cardiac_muscle | 2.38031619 |
| 22 | MP0001544_abnormal_cardiovascular_syste | 2.35892769 |
| 23 | MP0005385_cardiovascular_system_phenoty | 2.35892769 |
| 24 | MP0005369_muscle_phenotype | 2.32236911 |
| 25 | MP0000759_abnormal_skeletal_muscle | 2.28848331 |
| 26 | MP0006138_congestive_heart_failure | 2.16231747 |
| 27 | MP0004510_myositis | 2.11686520 |
| 28 | MP0004085_abnormal_heartbeat | 2.01184174 |
| 29 | MP0004233_abnormal_muscle_weight | 1.97794848 |
| 30 | MP0003828_pulmonary_edema | 1.96403921 |
| 31 | MP0003221_abnormal_cardiomyocyte_apopto | 1.73954156 |
| 32 | MP0002127_abnormal_cardiovascular_syste | 1.53894336 |
| 33 | MP0006036_abnormal_mitochondrial_physio | 1.53278666 |
| 34 | MP0002332_abnormal_exercise_endurance | 1.49438809 |
| 35 | MP0003950_abnormal_plasma_membrane | 1.43573749 |
| 36 | MP0005666_abnormal_adipose_tissue | 1.35775630 |
| 37 | MP0005670_abnormal_white_adipose | 1.24067735 |
| 38 | MP0002108_abnormal_muscle_morphology | 1.10381911 |
| 39 | MP0005423_abnormal_somatic_nervous | 1.05799924 |
| 40 | MP0002234_abnormal_pharynx_morphology | 1.05689850 |
| 41 | MP0000343_altered_response_to | 1.03180881 |
| 42 | MP0003879_abnormal_hair_cell | 1.02922843 |
| 43 | MP0005375_adipose_tissue_phenotype | 1.00788103 |
| 44 | MP0000266_abnormal_heart_morphology | 1.00139899 |
| 45 | MP0004185_abnormal_adipocyte_glucose | 0.93339004 |
| 46 | MP0005165_increased_susceptibility_to | 0.92848468 |
| 47 | MP0000013_abnormal_adipose_tissue | 0.92517717 |
| 48 | MP0006035_abnormal_mitochondrial_morpho | 0.92270990 |
| 49 | MP0000733_abnormal_muscle_development | 0.92089151 |
| 50 | MP0003279_aneurysm | 0.89692856 |
| 51 | MP0001661_extended_life_span | 0.89091213 |
| 52 | MP0003567_abnormal_fetal_cardiomyocyte | 0.88278561 |
| 53 | MP0005623_abnormal_meninges_morphology | 0.87894329 |
| 54 | MP0002909_abnormal_adrenal_gland | 0.86721938 |
| 55 | MP0010368_abnormal_lymphatic_system | 0.80730157 |
| 56 | MP0002734_abnormal_mechanical_nocicepti | 0.77524175 |
| 57 | MP0004859_abnormal_synaptic_plasticity | 0.75899648 |
| 58 | MP0005266_abnormal_metabolism | 0.75646861 |
| 59 | MP0000230_abnormal_systemic_arterial | 0.72532690 |
| 60 | MP0000003_abnormal_adipose_tissue | 0.69675903 |
| 61 | MP0002971_abnormal_brown_adipose | 0.66938172 |
| 62 | MP0002128_abnormal_blood_circulation | 0.66092255 |
| 63 | MP0004043_abnormal_pH_regulation | 0.63436559 |
| 64 | MP0003880_abnormal_central_pattern | 0.63031240 |
| 65 | MP0008569_lethality_at_weaning | 0.62906820 |
| 66 | MP0008961_abnormal_basal_metabolism | 0.62303348 |
| 67 | MP0004270_analgesia | 0.61297169 |
| 68 | MP0009780_abnormal_chondrocyte_physiolo | 0.59733209 |
| 69 | MP0003566_abnormal_cell_adhesion | 0.56040383 |
| 70 | MP0002249_abnormal_larynx_morphology | 0.54507517 |
| 71 | MP0002063_abnormal_learning/memory/cond | 0.53620221 |
| 72 | MP0002822_catalepsy | 0.53257724 |
| 73 | MP0004147_increased_porphyrin_level | 0.53168320 |
| 74 | MP0003045_fibrosis | 0.52604236 |
| 75 | MP0004924_abnormal_behavior | 0.50302181 |
| 76 | MP0005386_behavior/neurological_phenoty | 0.50302181 |
| 77 | MP0001346_abnormal_lacrimal_gland | 0.48008103 |
| 78 | MP0000767_abnormal_smooth_muscle | 0.47633393 |
| 79 | MP0002078_abnormal_glucose_homeostasis | 0.47399716 |
| 80 | MP0003705_abnormal_hypodermis_morpholog | 0.46721056 |
| 81 | MP0001958_emphysema | 0.45492834 |
| 82 | MP0003329_amyloid_beta_deposits | 0.45081506 |
| 83 | MP0005535_abnormal_body_temperature | 0.45057475 |
| 84 | MP0009046_muscle_twitch | 0.44958719 |
| 85 | MP0001502_abnormal_circadian_rhythm | 0.44745159 |
| 86 | MP0001486_abnormal_startle_reflex | 0.42257065 |
| 87 | MP0001879_abnormal_lymphatic_vessel | 0.41450804 |
| 88 | MP0005187_abnormal_penis_morphology | 0.41309256 |
| 89 | MP0003635_abnormal_synaptic_transmissio | 0.41212343 |
| 90 | MP0001501_abnormal_sleep_pattern | 0.39934897 |
| 91 | MP0006276_abnormal_autonomic_nervous | 0.38577095 |
| 92 | MP0004134_abnormal_chest_morphology | 0.37750582 |
| 93 | MP0010030_abnormal_orbit_morphology | 0.37345521 |
| 94 | MP0000762_abnormal_tongue_morphology | 0.36927236 |
| 95 | MP0002638_abnormal_pupillary_reflex | 0.35805486 |
| 96 | MP0005319_abnormal_enzyme/_coenzyme | 0.35512778 |
| 97 | MP0002272_abnormal_nervous_system | 0.35396638 |
| 98 | MP0002925_abnormal_cardiovascular_devel | 0.35167609 |
| 99 | MP0003948_abnormal_gas_homeostasis | 0.35024064 |
| 100 | MP0001299_abnormal_eye_distance/ | 0.34572476 |
| 101 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.34227979 |
| 102 | MP0005167_abnormal_blood-brain_barrier | 0.33889858 |
| 103 | MP0005166_decreased_susceptibility_to | 0.33793518 |
| 104 | MP0002572_abnormal_emotion/affect_behav | 0.33302603 |
| 105 | MP0004858_abnormal_nervous_system | 0.32806893 |
| 106 | MP0005409_darkened_coat_color | 0.32768781 |
| 107 | MP0001440_abnormal_grooming_behavior | 0.32203563 |
| 108 | MP0005503_abnormal_tendon_morphology | 0.32023618 |
| 109 | MP0002114_abnormal_axial_skeleton | 0.31607970 |
| 110 | MP0008874_decreased_physiological_sensi | 0.31244763 |
| 111 | MP0005334_abnormal_fat_pad | 0.29190692 |
| 112 | MP0002064_seizures | 0.28915264 |
| 113 | MP0009745_abnormal_behavioral_response | 0.28336639 |
| 114 | MP0003633_abnormal_nervous_system | 0.28194749 |
| 115 | MP0001784_abnormal_fluid_regulation | 0.28104348 |
| 116 | MP0002735_abnormal_chemical_nociception | 0.27177771 |
| 117 | MP0002067_abnormal_sensory_capabilities | 0.26893183 |
| 118 | MP0001614_abnormal_blood_vessel | 0.24635603 |
| 119 | MP0005595_abnormal_vascular_smooth | 0.23440975 |
| 120 | MP0002066_abnormal_motor_capabilities/c | 0.22975093 |
| 121 | MP0005452_abnormal_adipose_tissue | 0.21385212 |
| 122 | MP0005451_abnormal_body_composition | 0.21368369 |
| 123 | MP0004272_abnormal_basement_membrane | 0.21068997 |
| 124 | MP0005275_abnormal_skin_tensile | 0.20837484 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Sudden death (HP:0001699) | 7.63157822 |
| 2 | Calf muscle hypertrophy (HP:0008981) | 6.63504218 |
| 3 | Exercise-induced myalgia (HP:0003738) | 6.39536987 |
| 4 | Muscle hypertrophy of the lower extremities (HP:0008968) | 6.31009997 |
| 5 | Muscle fiber splitting (HP:0003555) | 6.10069135 |
| 6 | Exercise-induced muscle cramps (HP:0003710) | 6.04497704 |
| 7 | Ventricular tachycardia (HP:0004756) | 5.98826570 |
| 8 | Abnormality of the calf musculature (HP:0001430) | 5.53718913 |
| 9 | Atrial fibrillation (HP:0005110) | 5.52209027 |
| 10 | Hyporeflexia of lower limbs (HP:0002600) | 5.36386092 |
| 11 | Primary atrial arrhythmia (HP:0001692) | 5.16896262 |
| 12 | Supraventricular tachycardia (HP:0004755) | 4.97842746 |
| 13 | Subaortic stenosis (HP:0001682) | 4.88738608 |
| 14 | Abnormality of the left ventricular outflow tract (HP:0011103) | 4.88738608 |
| 15 | Supraventricular arrhythmia (HP:0005115) | 4.87081555 |
| 16 | Myoglobinuria (HP:0002913) | 4.73932120 |
| 17 | Lipoatrophy (HP:0100578) | 4.70199739 |
| 18 | Muscle fiber inclusion bodies (HP:0100299) | 4.67153678 |
| 19 | EMG: myopathic abnormalities (HP:0003458) | 4.66111657 |
| 20 | Syncope (HP:0001279) | 4.56797989 |
| 21 | Right ventricular cardiomyopathy (HP:0011663) | 4.53272184 |
| 22 | Bundle branch block (HP:0011710) | 4.50528098 |
| 23 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 4.50430248 |
| 24 | Difficulty running (HP:0009046) | 4.25830141 |
| 25 | Increased connective tissue (HP:0009025) | 4.22433214 |
| 26 | Ulnar deviation of the wrist (HP:0003049) | 4.21592030 |
| 27 | Prolonged QT interval (HP:0001657) | 4.17768300 |
| 28 | Type 1 muscle fiber predominance (HP:0003803) | 4.14736855 |
| 29 | Dilated cardiomyopathy (HP:0001644) | 4.00477458 |
| 30 | Myotonia (HP:0002486) | 3.88776624 |
| 31 | Ventricular arrhythmia (HP:0004308) | 3.84689799 |
| 32 | Nemaline bodies (HP:0003798) | 3.83310832 |
| 33 | Asymmetric septal hypertrophy (HP:0001670) | 3.82764907 |
| 34 | Palpitations (HP:0001962) | 3.81071690 |
| 35 | Heart block (HP:0012722) | 3.71617425 |
| 36 | Ventricular fibrillation (HP:0001663) | 3.70369879 |
| 37 | Calcaneovalgus deformity (HP:0001848) | 3.59389264 |
| 38 | Abnormal atrioventricular conduction (HP:0005150) | 3.52175546 |
| 39 | Atrioventricular block (HP:0001678) | 3.51404570 |
| 40 | Rhabdomyolysis (HP:0003201) | 3.50122388 |
| 41 | Difficulty climbing stairs (HP:0003551) | 3.40482131 |
| 42 | Deformed tarsal bones (HP:0008119) | 3.16896178 |
| 43 | Malignant hyperthermia (HP:0002047) | 3.12247725 |
| 44 | Absent phalangeal crease (HP:0006109) | 3.11434969 |
| 45 | Abnormal EKG (HP:0003115) | 3.10784199 |
| 46 | Increased variability in muscle fiber diameter (HP:0003557) | 3.05438348 |
| 47 | Muscle stiffness (HP:0003552) | 3.01258511 |
| 48 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.98082057 |
| 49 | Neck muscle weakness (HP:0000467) | 2.86725145 |
| 50 | Distal lower limb muscle weakness (HP:0009053) | 2.77149045 |
| 51 | Areflexia of lower limbs (HP:0002522) | 2.75687726 |
| 52 | Left ventricular hypertrophy (HP:0001712) | 2.70222098 |
| 53 | Fetal akinesia sequence (HP:0001989) | 2.68377629 |
| 54 | Limb-girdle muscle atrophy (HP:0003797) | 2.60682590 |
| 55 | Abnormal finger flexion creases (HP:0006143) | 2.53647331 |
| 56 | Distal arthrogryposis (HP:0005684) | 2.49774436 |
| 57 | Weak cry (HP:0001612) | 2.45336526 |
| 58 | Distal lower limb amyotrophy (HP:0008944) | 2.44186594 |
| 59 | Rimmed vacuoles (HP:0003805) | 2.41516882 |
| 60 | Gowers sign (HP:0003391) | 2.41077579 |
| 61 | Myopathic facies (HP:0002058) | 2.39291957 |
| 62 | Slender build (HP:0001533) | 2.39258833 |
| 63 | Mildly elevated creatine phosphokinase (HP:0008180) | 2.39115955 |
| 64 | Testicular atrophy (HP:0000029) | 2.37545066 |
| 65 | Spinal rigidity (HP:0003306) | 2.36195763 |
| 66 | EMG: neuropathic changes (HP:0003445) | 2.32346049 |
| 67 | Palmoplantar keratoderma (HP:0000982) | 2.29225373 |
| 68 | Ketoacidosis (HP:0001993) | 2.27294705 |
| 69 | Muscular dystrophy (HP:0003560) | 2.27275118 |
| 70 | Dysmetric saccades (HP:0000641) | 2.23762120 |
| 71 | Facial diplegia (HP:0001349) | 2.23620697 |
| 72 | Round ear (HP:0100830) | 2.23197689 |
| 73 | Abnormality of the foot musculature (HP:0001436) | 2.20116070 |
| 74 | Hypoplastic ischia (HP:0003175) | 2.19980257 |
| 75 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.18699515 |
| 76 | Hepatic necrosis (HP:0002605) | 2.18649306 |
| 77 | Generalized muscle weakness (HP:0003324) | 2.16870743 |
| 78 | Foot dorsiflexor weakness (HP:0009027) | 2.12171651 |
| 79 | Abnormality of the calcaneus (HP:0008364) | 2.12075495 |
| 80 | Hyperkalemia (HP:0002153) | 2.11732312 |
| 81 | Scapular winging (HP:0003691) | 2.10640163 |
| 82 | Acute necrotizing encephalopathy (HP:0006965) | 2.09345390 |
| 83 | Waddling gait (HP:0002515) | 2.08808354 |
| 84 | Lower limb amyotrophy (HP:0007210) | 2.07271614 |
| 85 | Frequent falls (HP:0002359) | 2.05667695 |
| 86 | Proximal amyotrophy (HP:0007126) | 2.05521329 |
| 87 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 2.04612690 |
| 88 | Sudden cardiac death (HP:0001645) | 1.99758485 |
| 89 | Popliteal pterygium (HP:0009756) | 1.93765151 |
| 90 | Hepatocellular necrosis (HP:0001404) | 1.91853015 |
| 91 | Abnormality of the shoulder girdle musculature (HP:0001435) | 1.91534034 |
| 92 | Abnormality of the ischium (HP:0003174) | 1.91404055 |
| 93 | Pheochromocytoma (HP:0002666) | 1.90130119 |
| 94 | Progressive muscle weakness (HP:0003323) | 1.89346448 |
| 95 | Increased muscle lipid content (HP:0009058) | 1.89009364 |
| 96 | Hip contracture (HP:0003273) | 1.88940682 |
| 97 | Respiratory insufficiency due to muscle weakness (HP:0002747) | 1.88139073 |
| 98 | Hypoglycemic coma (HP:0001325) | 1.86596560 |
| 99 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 1.83020178 |
| 100 | Abnormality of the neuromuscular junction (HP:0003398) | 1.82976012 |
| 101 | Fatigable weakness (HP:0003473) | 1.82976012 |
| 102 | Congestive heart failure (HP:0001635) | 1.79659176 |
| 103 | Ragged-red muscle fibers (HP:0003200) | 1.77830877 |
| 104 | Bulbar palsy (HP:0001283) | 1.75722074 |
| 105 | Acute encephalopathy (HP:0006846) | 1.75473301 |
| 106 | Conjunctival hamartoma (HP:0100780) | 1.73470493 |
| 107 | Progressive macrocephaly (HP:0004481) | 1.73379102 |
| 108 | Large for gestational age (HP:0001520) | 1.72092014 |
| 109 | Abnormality of fatty-acid metabolism (HP:0004359) | 1.71513971 |
| 110 | Abnormality of alanine metabolism (HP:0010916) | 1.71432618 |
| 111 | Hyperalaninemia (HP:0003348) | 1.71432618 |
| 112 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.71432618 |
| 113 | Limb-girdle muscle weakness (HP:0003325) | 1.70546266 |
| 114 | Limited hip movement (HP:0008800) | 1.70493376 |
| 115 | Central scotoma (HP:0000603) | 1.70069795 |
| 116 | Mitochondrial inheritance (HP:0001427) | 1.69537767 |
| 117 | Exercise intolerance (HP:0003546) | 1.69392353 |
| 118 | Nonprogressive disorder (HP:0003680) | 1.64393847 |
| 119 | Type 2 muscle fiber atrophy (HP:0003554) | 1.54618870 |
| 120 | Easy fatigability (HP:0003388) | 1.49692377 |
| 121 | Metatarsus adductus (HP:0001840) | 1.49060674 |
| 122 | Muscle fiber atrophy (HP:0100295) | 1.47307824 |
| 123 | Steppage gait (HP:0003376) | 1.46379830 |
| 124 | Ankle clonus (HP:0011448) | 1.45104371 |
| 125 | Generalized amyotrophy (HP:0003700) | 1.42443988 |
| 126 | Long clavicles (HP:0000890) | 1.40116116 |
| 127 | Abnormality of the hip-girdle musculature (HP:0001445) | 1.39584767 |
| 128 | Abnormality of the musculature of the pelvis (HP:0001469) | 1.39584767 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | OBSCN | 5.86059740 |
| 2 | TTN | 5.83140717 |
| 3 | PHKG1 | 4.29599024 |
| 4 | PHKG2 | 4.29599024 |
| 5 | LMTK2 | 3.41927740 |
| 6 | DMPK | 3.12563632 |
| 7 | PDK4 | 3.03778866 |
| 8 | PDK3 | 3.03778866 |
| 9 | MUSK | 2.83509752 |
| 10 | MYLK | 2.82308954 |
| 11 | TRIB3 | 2.50652914 |
| 12 | PKN2 | 2.37358360 |
| 13 | PINK1 | 2.31994121 |
| 14 | NEK1 | 2.28928072 |
| 15 | PIK3CA | 1.90410876 |
| 16 | PDK2 | 1.85303401 |
| 17 | BCKDK | 1.80564066 |
| 18 | MARK1 | 1.66590969 |
| 19 | TIE1 | 1.62503715 |
| 20 | STK24 | 1.46328939 |
| 21 | MAP3K7 | 1.33773388 |
| 22 | GRK7 | 1.27401171 |
| 23 | CAMK2D | 1.25954792 |
| 24 | PAK3 | 1.19822222 |
| 25 | EPHA4 | 1.18406650 |
| 26 | PRKD1 | 1.17334052 |
| 27 | MAPK12 | 1.16353607 |
| 28 | MOS | 1.13679922 |
| 29 | LIMK1 | 1.11291789 |
| 30 | ZAK | 1.10148543 |
| 31 | EEF2K | 1.08965750 |
| 32 | STK38 | 1.07173185 |
| 33 | ILK | 1.03056405 |
| 34 | INSRR | 0.99730293 |
| 35 | PIK3CG | 0.99290065 |
| 36 | CDC42BPA | 0.98654572 |
| 37 | MAP2K3 | 0.97717400 |
| 38 | ROCK1 | 0.96833161 |
| 39 | RIPK1 | 0.96632534 |
| 40 | MAP3K13 | 0.89520583 |
| 41 | NME1 | 0.86920111 |
| 42 | PRKAA1 | 0.86585933 |
| 43 | WNK1 | 0.84810280 |
| 44 | MAP2K4 | 0.84221487 |
| 45 | MAP3K5 | 0.79077226 |
| 46 | CCNB1 | 0.78571670 |
| 47 | MAPKAPK3 | 0.77896704 |
| 48 | PRPF4B | 0.76987455 |
| 49 | PRKAA2 | 0.75488270 |
| 50 | WNK4 | 0.73411161 |
| 51 | PKN1 | 0.71833619 |
| 52 | CAMK4 | 0.71124867 |
| 53 | MAP3K4 | 0.70168778 |
| 54 | ARAF | 0.69890811 |
| 55 | DYRK1B | 0.69313571 |
| 56 | CAMK2A | 0.69225080 |
| 57 | CAMK2B | 0.69049130 |
| 58 | TRPM7 | 0.67910419 |
| 59 | UHMK1 | 0.65424570 |
| 60 | PAK6 | 0.65274003 |
| 61 | CAMK1 | 0.64202553 |
| 62 | PRKD3 | 0.63781706 |
| 63 | DAPK3 | 0.63090737 |
| 64 | MAPK4 | 0.62775663 |
| 65 | EPHB1 | 0.60738609 |
| 66 | PDGFRA | 0.60185767 |
| 67 | ROCK2 | 0.56258552 |
| 68 | MAP2K1 | 0.56009390 |
| 69 | PTK2B | 0.52958631 |
| 70 | CAMK2G | 0.49955700 |
| 71 | PRKACB | 0.49745329 |
| 72 | AKT2 | 0.48896317 |
| 73 | PRKCH | 0.48764436 |
| 74 | STK38L | 0.48700538 |
| 75 | MAP3K9 | 0.48125623 |
| 76 | MAP3K3 | 0.47593271 |
| 77 | PDPK1 | 0.47214550 |
| 78 | SGK3 | 0.45239712 |
| 79 | MAPK10 | 0.42655626 |
| 80 | PRKCE | 0.41809835 |
| 81 | TAOK1 | 0.41803092 |
| 82 | RPS6KC1 | 0.41517082 |
| 83 | RPS6KL1 | 0.41517082 |
| 84 | MAPK11 | 0.41469682 |
| 85 | STK4 | 0.41025409 |
| 86 | PDK1 | 0.40801334 |
| 87 | PRKACA | 0.40016398 |
| 88 | LATS2 | 0.39468836 |
| 89 | SIK1 | 0.38808158 |
| 90 | ICK | 0.37843535 |
| 91 | MAP3K11 | 0.37706519 |
| 92 | FLT3 | 0.36799371 |
| 93 | MAP3K6 | 0.35790491 |
| 94 | PRKACG | 0.35714944 |
| 95 | SGK1 | 0.35648941 |
| 96 | CDK5 | 0.34681400 |
| 97 | NTRK1 | 0.34297324 |
| 98 | NTRK3 | 0.33500320 |
| 99 | RPS6KA6 | 0.33067118 |
| 100 | SGK494 | 0.32931948 |
| 101 | SGK223 | 0.32931948 |
| 102 | GRK5 | 0.32357421 |
| 103 | RET | 0.32211863 |
| 104 | DAPK2 | 0.31432509 |
| 105 | MAP2K6 | 0.31277493 |
| 106 | TGFBR2 | 0.31135964 |
| 107 | RPS6KA3 | 0.29653495 |
| 108 | TESK1 | 0.28687401 |
| 109 | PRKG1 | 0.28224720 |
| 110 | MAPK13 | 0.27433961 |
| 111 | NEK9 | 0.26845435 |
| 112 | CAMK1G | 0.25679837 |
| 113 | FER | 0.25091969 |
| 114 | CAMKK1 | 0.25065257 |
| 115 | MAP3K1 | 0.24378395 |
| 116 | SGK2 | 0.24335439 |
| 117 | STK11 | 0.24185757 |
| 118 | TAOK2 | 0.22795262 |
| 119 | NTRK2 | 0.21904750 |
| 120 | JAK1 | 0.21358636 |
| 121 | PTK6 | 0.21152280 |
| 122 | MARK2 | 0.21041689 |
| 123 | TNK2 | 0.20896812 |
| 124 | RPS6KA2 | 0.19996072 |
| 125 | MAPK7 | 0.19778541 |
| 126 | RAF1 | 0.19672933 |
| 127 | BRAF | 0.19434380 |
| 128 | KSR2 | 0.19405268 |
| 129 | CDK19 | 0.17714252 |
| 130 | RPS6KA1 | 0.17014213 |
| 131 | STK39 | 0.15376143 |
| 132 | MTOR | 0.12971904 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 5.27513384 |
| 2 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 4.16622473 |
| 3 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 3.97449828 |
| 4 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 3.89351311 |
| 5 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 3.85177085 |
| 6 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.19059769 |
| 7 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 2.79738610 |
| 8 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.62993624 |
| 9 | Parkinsons disease_Homo sapiens_hsa05012 | 2.40707721 |
| 10 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.30253280 |
| 11 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.28057602 |
| 12 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 2.17028351 |
| 13 | Carbon metabolism_Homo sapiens_hsa01200 | 2.04460545 |
| 14 | Alzheimers disease_Homo sapiens_hsa05010 | 1.89208934 |
| 15 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.76334074 |
| 16 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.68134927 |
| 17 | Viral myocarditis_Homo sapiens_hsa05416 | 1.63571923 |
| 18 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.59233942 |
| 19 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.43620091 |
| 20 | Huntingtons disease_Homo sapiens_hsa05016 | 1.39427365 |
| 21 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.31352832 |
| 22 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.25405023 |
| 23 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.23188068 |
| 24 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.22062562 |
| 25 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 1.21493084 |
| 26 | Insulin resistance_Homo sapiens_hsa04931 | 1.15788976 |
| 27 | Insulin signaling pathway_Homo sapiens_hsa04910 | 1.10355419 |
| 28 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 1.09789915 |
| 29 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.06084809 |
| 30 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.05553818 |
| 31 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.04755348 |
| 32 | Insulin secretion_Homo sapiens_hsa04911 | 1.00525959 |
| 33 | Circadian entrainment_Homo sapiens_hsa04713 | 0.98870082 |
| 34 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.97680283 |
| 35 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.97375819 |
| 36 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.94306842 |
| 37 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.88824845 |
| 38 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.87964037 |
| 39 | Renin secretion_Homo sapiens_hsa04924 | 0.87052774 |
| 40 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.86559032 |
| 41 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.81681605 |
| 42 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.79200929 |
| 43 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.78331352 |
| 44 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.78273857 |
| 45 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.76628331 |
| 46 | Focal adhesion_Homo sapiens_hsa04510 | 0.73648957 |
| 47 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.73525157 |
| 48 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.71774640 |
| 49 | Olfactory transduction_Homo sapiens_hsa04740 | 0.70526948 |
| 50 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.70352520 |
| 51 | Glioma_Homo sapiens_hsa05214 | 0.68950261 |
| 52 | Melanogenesis_Homo sapiens_hsa04916 | 0.67948588 |
| 53 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.64959330 |
| 54 | Tight junction_Homo sapiens_hsa04530 | 0.63227244 |
| 55 | Lysine degradation_Homo sapiens_hsa00310 | 0.63077138 |
| 56 | Circadian rhythm_Homo sapiens_hsa04710 | 0.62925115 |
| 57 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.62462379 |
| 58 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.61061241 |
| 59 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.60036589 |
| 60 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.59769387 |
| 61 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.59502131 |
| 62 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.58193054 |
| 63 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.56591479 |
| 64 | Salivary secretion_Homo sapiens_hsa04970 | 0.56339957 |
| 65 | Long-term depression_Homo sapiens_hsa04730 | 0.55925237 |
| 66 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.55736210 |
| 67 | Long-term potentiation_Homo sapiens_hsa04720 | 0.54379739 |
| 68 | GABAergic synapse_Homo sapiens_hsa04727 | 0.53082735 |
| 69 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.51803702 |
| 70 | Taste transduction_Homo sapiens_hsa04742 | 0.51471426 |
| 71 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.50106425 |
| 72 | Morphine addiction_Homo sapiens_hsa05032 | 0.50081183 |
| 73 | Galactose metabolism_Homo sapiens_hsa00052 | 0.49054762 |
| 74 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.48835255 |
| 75 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.47712710 |
| 76 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.46427104 |
| 77 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.43681628 |
| 78 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.43139549 |
| 79 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.42261774 |
| 80 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.41636924 |
| 81 | Gap junction_Homo sapiens_hsa04540 | 0.39478466 |
| 82 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.39128123 |
| 83 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.37763432 |
| 84 | Bile secretion_Homo sapiens_hsa04976 | 0.36173480 |
| 85 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.36119063 |
| 86 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.36000618 |
| 87 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.35624039 |
| 88 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.35147027 |
| 89 | Amoebiasis_Homo sapiens_hsa05146 | 0.34857967 |
| 90 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.34677461 |
| 91 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.34345299 |
| 92 | Nicotine addiction_Homo sapiens_hsa05033 | 0.34166254 |
| 93 | Cocaine addiction_Homo sapiens_hsa05030 | 0.33812170 |
| 94 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.33376609 |
| 95 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.32777001 |
| 96 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.32208522 |
| 97 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.31819419 |
| 98 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.31512455 |
| 99 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.31093240 |
| 100 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.30773258 |
| 101 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.29696672 |
| 102 | Adherens junction_Homo sapiens_hsa04520 | 0.29499815 |
| 103 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.28691445 |
| 104 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.28413072 |
| 105 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.26828559 |
| 106 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.26586473 |
| 107 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.26261961 |
| 108 | Platelet activation_Homo sapiens_hsa04611 | 0.24951348 |
| 109 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.24616217 |
| 110 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.23703070 |
| 111 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.23694134 |
| 112 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.23615475 |
| 113 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.23581419 |
| 114 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.22661182 |
| 115 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.21735448 |
| 116 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.21442012 |

