CORO7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the coronin protein family. However, unlike other coronin proteins, it is not an actin-binding protein but rather functions as an F-actin regulator directing anterograde Golgi to endosome transport. The encoded protein has two tandem WD-40 domain repeats and localizes to the trans-Golgi network. The protein undergoes K33-linked polyubiquitination via an E3 ligase complex. It is thought to play an essential role in maintenance of Golgi apparatus morphology. Alternative splicing results in multiple transcripts variants; some of which form read-through transcripts with a neighboring gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.90963994
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.25092156
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.25092156
4positive regulation of B cell differentiation (GO:0045579)5.20525901
5regulation of B cell receptor signaling pathway (GO:0050855)5.04948612
6B cell receptor signaling pathway (GO:0050853)5.04232003
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.95849923
8antigen processing and presentation of endogenous antigen (GO:0019883)4.88527490
9leukocyte aggregation (GO:0070486)4.73894205
10mast cell activation (GO:0045576)4.73679008
11regulation of B cell differentiation (GO:0045577)4.60344406
12negative regulation of phagocytosis (GO:0050765)4.56162872
13mast cell activation involved in immune response (GO:0002279)4.37646397
14mast cell degranulation (GO:0043303)4.37646397
15detection of other organism (GO:0098543)4.32601619
16detection of bacterium (GO:0016045)4.31139925
17negative regulation of cell killing (GO:0031342)4.30443888
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.30443888
19negative regulation of interleukin-12 production (GO:0032695)4.25104979
20regulation of gamma-delta T cell differentiation (GO:0045586)4.23340415
21macrophage activation involved in immune response (GO:0002281)4.14255155
22neutrophil activation involved in immune response (GO:0002283)4.04459689
23regulation of gamma-delta T cell activation (GO:0046643)3.95671649
24regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.94806408
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.93374763
26response to interleukin-15 (GO:0070672)3.82551799
27T cell migration (GO:0072678)3.81911746
28negative regulation of lymphocyte mediated immunity (GO:0002707)3.81791246
29defense response to protozoan (GO:0042832)3.78721898
30T cell homeostasis (GO:0043029)3.74363816
31megakaryocyte development (GO:0035855)3.70550807
32respiratory burst (GO:0045730)3.66551417
33regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.62068097
34cellular response to interleukin-15 (GO:0071350)3.59834361
35response to protozoan (GO:0001562)3.56077968
36negative regulation of leukocyte mediated immunity (GO:0002704)3.55411176
37immunoglobulin mediated immune response (GO:0016064)3.54190798
38antigen processing and presentation via MHC class Ib (GO:0002475)3.51441761
39neutrophil activation (GO:0042119)3.51365336
40leukocyte degranulation (GO:0043299)3.49385893
41negative regulation of T cell mediated immunity (GO:0002710)3.49088752
42negative thymic T cell selection (GO:0045060)3.46351659
43detection of external biotic stimulus (GO:0098581)3.44613526
44mature B cell differentiation (GO:0002335)3.42215326
45negative T cell selection (GO:0043383)3.41898586
46myeloid cell activation involved in immune response (GO:0002275)3.40758542
47regulation of T cell tolerance induction (GO:0002664)3.37574652
48neutrophil mediated immunity (GO:0002446)3.36380402
49lymphocyte homeostasis (GO:0002260)3.35056149
50antigen receptor-mediated signaling pathway (GO:0050851)3.34875781
51positive regulation of granulocyte differentiation (GO:0030854)3.32661525
52angiogenesis involved in wound healing (GO:0060055)3.31024515
53response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.29777939
54response to host immune response (GO:0052572)3.29777939
55positive thymic T cell selection (GO:0045059)3.29544120
56leukocyte homeostasis (GO:0001776)3.24641588
57regulation of tolerance induction (GO:0002643)3.23731653
58regulation of T cell receptor signaling pathway (GO:0050856)3.22585947
59B cell homeostasis (GO:0001782)3.21730864
60regulation of myeloid leukocyte mediated immunity (GO:0002886)3.20730610
61cellular extravasation (GO:0045123)3.20249565
62mature B cell differentiation involved in immune response (GO:0002313)3.19562091
63interferon-gamma production (GO:0032609)3.16985792
64regulation of leukocyte degranulation (GO:0043300)3.16627327
65Arp2/3 complex-mediated actin nucleation (GO:0034314)3.16354805
66regulation of mast cell activation involved in immune response (GO:0033006)3.16332163
67granulocyte activation (GO:0036230)3.13292393
68tolerance induction (GO:0002507)3.12797832
69negative regulation of interleukin-6 production (GO:0032715)3.10572216
70positive regulation of mast cell activation (GO:0033005)3.04412621
71negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.03776778
72negative regulation of innate immune response (GO:0045824)3.03446036
73detection of biotic stimulus (GO:0009595)3.03365515
74macrophage activation (GO:0042116)3.02673752
75mucosal-associated lymphoid tissue development (GO:0048537)3.02328129
76Peyers patch development (GO:0048541)3.02328129
77myeloid dendritic cell activation (GO:0001773)3.01918505
78microglial cell activation (GO:0001774)3.01614270
79regulation of dendritic cell antigen processing and presentation (GO:0002604)3.00404756
80negative regulation of cytokine production involved in immune response (GO:0002719)3.00254725
81positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.99573177
82response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.98159946
83response to host (GO:0075136)2.98159946
84response to host defenses (GO:0052200)2.98159946
85regulation of antigen processing and presentation (GO:0002577)2.97714887
86negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.96971946
87germinal center formation (GO:0002467)2.95105308
88activated T cell proliferation (GO:0050798)2.93340860
89regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.91954734
90regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.91876118
91regulation of natural killer cell mediated immunity (GO:0002715)2.91876118
92B cell mediated immunity (GO:0019724)2.90442488
93response to peptidoglycan (GO:0032494)2.87476977
94histone H3-K4 trimethylation (GO:0080182)2.86236493
95mannose metabolic process (GO:0006013)2.85693731
96regulation of interleukin-2 biosynthetic process (GO:0045076)2.85421502
97T cell selection (GO:0045058)2.84836877
98regulation of interferon-beta biosynthetic process (GO:0045357)2.84194173
99detection of molecule of bacterial origin (GO:0032490)2.83898630
100lipopolysaccharide-mediated signaling pathway (GO:0031663)2.82871422
101T cell receptor signaling pathway (GO:0050852)2.81160091
102myeloid dendritic cell differentiation (GO:0043011)2.79614119
103positive T cell selection (GO:0043368)2.78957646
104regulation of T cell mediated cytotoxicity (GO:0001914)2.78486589
105response to type I interferon (GO:0034340)2.78439872
106positive regulation of tolerance induction (GO:0002645)2.77016950
107cellular response to type I interferon (GO:0071357)2.75714359
108type I interferon signaling pathway (GO:0060337)2.75714359
109response to muramyl dipeptide (GO:0032495)2.75690954
110thymic T cell selection (GO:0045061)2.75281266
111natural killer cell differentiation (GO:0001779)2.75086268
112ribosomal small subunit assembly (GO:0000028)2.74075820
113positive regulation by symbiont of host defense response (GO:0052509)2.73702746
114modulation by symbiont of host defense response (GO:0052031)2.73702746
115modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.73702746
116modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.73702746
117positive regulation by organism of defense response of other organism involved in symbiotic interact2.73702746
118modulation by symbiont of host immune response (GO:0052553)2.73702746
119negative regulation of erythrocyte differentiation (GO:0045647)2.72501324
120positive regulation of antigen processing and presentation (GO:0002579)2.72287609
121immune response-activating cell surface receptor signaling pathway (GO:0002429)2.70077168
122regulation of mast cell activation (GO:0033003)2.69851009
123regulation of granulocyte differentiation (GO:0030852)2.68015349
124myeloid leukocyte mediated immunity (GO:0002444)2.67975947
125cellular response to zinc ion (GO:0071294)2.66209095
126lymph node development (GO:0048535)2.66138421
127leukocyte cell-cell adhesion (GO:0007159)2.65126606
128definitive hemopoiesis (GO:0060216)2.65077680
129NIK/NF-kappaB signaling (GO:0038061)2.64670909
130positive regulation of interleukin-2 production (GO:0032743)2.63121540
131regulation of alpha-beta T cell proliferation (GO:0046640)2.62829556
132positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.62107086
133positive regulation of B cell activation (GO:0050871)2.61858004
134regulation of mast cell degranulation (GO:0043304)2.61633839
135myeloid leukocyte activation (GO:0002274)2.61271537
136interferon-gamma-mediated signaling pathway (GO:0060333)2.60978533
137negative regulation of T cell receptor signaling pathway (GO:0050860)2.60272249
138natural killer cell activation (GO:0030101)2.59804170
139regulation of interleukin-12 biosynthetic process (GO:0045075)2.58368025
140negative regulation of B cell proliferation (GO:0030889)2.57496446

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.08087530
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.79689044
3MECOM_23826213_ChIP-Seq_KASUMI_Mouse4.23403015
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.15051141
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.11209917
6SCL_19346495_ChIP-Seq_HPC-7_Human3.94202553
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.86682436
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.76507594
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.74223711
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.40879989
11* VDR_21846776_ChIP-Seq_THP-1_Human3.35091593
12MYC_22102868_ChIP-Seq_BL_Human3.25550756
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.05412443
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.93565582
15* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.92025755
16* IRF8_27001747_Chip-Seq_BMDM_Mouse2.83528249
17RUNX_20019798_ChIP-Seq_JUKART_Human2.69565161
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.61978549
19MYB_26560356_Chip-Seq_TH2_Human2.58258760
20SPI1_23547873_ChIP-Seq_NB4_Human2.58050041
21* VDR_24763502_ChIP-Seq_THP-1_Human2.57566694
22* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55993659
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.52370445
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.51314561
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.44068747
26* MAF_26560356_Chip-Seq_TH1_Human2.35480679
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.31688501
28RUNX1_22412390_ChIP-Seq_EML_Mouse2.30282550
29MYB_26560356_Chip-Seq_TH1_Human2.28189740
30* SPI1_23127762_ChIP-Seq_K562_Human2.23962663
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.22055434
32* UTX_26944678_Chip-Seq_JUKART_Human2.21421931
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.20794043
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.15553990
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.13757581
36BRD4_27068464_Chip-Seq_AML-cells_Mouse2.06896152
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.98659469
38TCF7_22412390_ChIP-Seq_EML_Mouse1.98347015
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.97701520
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.89196259
41* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88213882
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.87210564
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.80059106
44CIITA_25753668_ChIP-Seq_RAJI_Human1.76885060
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.76187249
46* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.73669997
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.68247214
48MAF_26560356_Chip-Seq_TH2_Human1.53977626
49* ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51153885
50GATA3_27048872_Chip-Seq_THYMUS_Human1.50666325
51BCL6_27268052_Chip-Seq_Bcells_Human1.49346524
52* GATA1_19941827_ChIP-Seq_MEL_Mouse1.47231987
53* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46943166
54GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.45279898
55KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44971066
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44224552
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.43568303
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.43159294
59PU_27001747_Chip-Seq_BMDM_Mouse1.42219333
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.40917637
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.40156211
62* BCOR_27268052_Chip-Seq_Bcells_Human1.39204710
63KDM2B_26808549_Chip-Seq_JURKAT_Human1.38761004
64KDM2B_26808549_Chip-Seq_DND41_Human1.38115135
65* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37663847
66NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.35724880
67FOXM1_23109430_ChIP-Seq_U2OS_Human1.34498870
68GATA1_19941826_ChIP-Seq_K562_Human1.31683647
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30552985
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29552343
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.28581928
72GATA1_22025678_ChIP-Seq_K562_Human1.26153011
73* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.24848667
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23763608
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.21602016
76STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20303386
77* P68_20966046_ChIP-Seq_HELA_Human1.19778350
78CTCF_27219007_Chip-Seq_ERYTHROID_Human1.19387576
79SA1_27219007_Chip-Seq_ERYTHROID_Human1.18675548
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17000732
81E2F4_17652178_ChIP-ChIP_JURKAT_Human1.14963626
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14894184
83GATA3_26560356_Chip-Seq_TH2_Human1.14552542
84PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14023882
85Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11804411
86MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10213651
87NCOR1_26117541_ChIP-Seq_K562_Human1.10207159
88VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.10137045
89PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06912230
90NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.04904516
91STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04723064
92PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02460787
93GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00756575
94FOXP3_21729870_ChIP-Seq_TREG_Human1.00413528
95FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98000632
96CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96592032
97RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95471948
98NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95056564
99KDM2B_26808549_Chip-Seq_K562_Human0.93949107
100SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93801304
101ETS1_22383799_ChIP-Seq_G1ME_Mouse0.93729720
102* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93279900
103CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92954489
104CTCF_26484167_Chip-Seq_Bcells_Mouse0.92720408
105SPI1_20517297_ChIP-Seq_HL60_Human0.92182758
106EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.91521990
107GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91500337
108SMC4_20622854_ChIP-Seq_HELA_Human0.91094932
109ELK3_25401928_ChIP-Seq_HUVEC_Human0.90457052
110CTCF_21964334_ChIP-Seq_BJAB-B_Human0.89569750
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87240414
112CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85499240
113PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82753887
114PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80843715
115GATA2_21666600_ChIP-Seq_HMVEC_Human0.79231290
116* VDR_23849224_ChIP-Seq_CD4+_Human0.79189150
117* VDR_24787735_ChIP-Seq_THP-1_Human0.74749045
118* LXR_22292898_ChIP-Seq_THP-1_Human0.73717215
119FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.73064534
120RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.71378638

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.07810129
2MP0002396_abnormal_hematopoietic_system3.39298434
3MP0005671_abnormal_response_to3.21624234
4MP0000685_abnormal_immune_system3.10843925
5MP0001800_abnormal_humoral_immune3.08321679
6MP0005387_immune_system_phenotype2.79429601
7MP0001790_abnormal_immune_system2.79429601
8MP0005000_abnormal_immune_tolerance2.79388334
9MP0002452_abnormal_antigen_presenting2.72512862
10MP0002420_abnormal_adaptive_immunity2.71010328
11MP0009785_altered_susceptibility_to2.68227727
12MP0001819_abnormal_immune_cell2.67321926
13MP0002723_abnormal_immune_serum2.66989782
14MP0003763_abnormal_thymus_physiology2.61980894
15MP0003436_decreased_susceptibility_to2.58328994
16MP0005464_abnormal_platelet_physiology2.56331685
17MP0005025_abnormal_response_to2.55713826
18MP0002398_abnormal_bone_marrow2.55567098
19MP0002419_abnormal_innate_immunity2.54115554
20MP0005174_abnormal_tail_pigmentation2.51096167
21MP0003303_peritoneal_inflammation2.40535080
22MP0003172_abnormal_lysosome_physiology2.32215763
23MP0002148_abnormal_hypersensitivity_rea2.29834176
24MP0000716_abnormal_immune_system2.28048763
25MP0000689_abnormal_spleen_morphology2.14011511
26MP0004808_abnormal_hematopoietic_stem2.10453562
27MP0002166_altered_tumor_susceptibility2.09629719
28MP0000569_abnormal_digit_pigmentation2.03875874
29MP0002722_abnormal_immune_system2.02969448
30MP0000465_gastrointestinal_hemorrhage2.00635669
31MP0003183_abnormal_peptide_metabolism1.95000132
32MP0002429_abnormal_blood_cell1.91363402
33MP0005409_darkened_coat_color1.86448577
34MP0000703_abnormal_thymus_morphology1.82550712
35MP0005397_hematopoietic_system_phenotyp1.81533762
36MP0001545_abnormal_hematopoietic_system1.81533762
37MP0002405_respiratory_system_inflammati1.79246052
38MP0001873_stomach_inflammation1.75617582
39MP0000015_abnormal_ear_pigmentation1.73459057
40MP0005075_abnormal_melanosome_morpholog1.70670578
41MP0006082_CNS_inflammation1.70254452
42MP0008260_abnormal_autophagy1.70252840
43MP0009278_abnormal_bone_marrow1.69674946
44MP0002006_tumorigenesis1.67300987
45MP0003300_gastrointestinal_ulcer1.63681406
46MP0010155_abnormal_intestine_physiology1.61579928
47MP0003866_abnormal_defecation1.60542666
48MP0009840_abnormal_foam_cell1.57601976
49MP0008057_abnormal_DNA_replication1.55229615
50MP0009333_abnormal_splenocyte_physiolog1.54539131
51MP0001845_abnormal_inflammatory_respons1.53105719
52MP0005058_abnormal_lysosome_morphology1.49275158
53MP0005310_abnormal_salivary_gland1.48503478
54MP0003724_increased_susceptibility_to1.46822867
55MP0001986_abnormal_taste_sensitivity1.43621030
56MP0004947_skin_inflammation1.36519137
57MP0004510_myositis1.30617078
58MP0002138_abnormal_hepatobiliary_system1.28220954
59MP0005451_abnormal_body_composition1.27634965
60MP0002998_abnormal_bone_remodeling1.27373130
61MP0001853_heart_inflammation1.26495927
62MP0003828_pulmonary_edema1.25154020
63MP0002095_abnormal_skin_pigmentation1.24963563
64MP0002933_joint_inflammation1.16999847
65MP0000920_abnormal_myelination1.15273160
66MP0000490_abnormal_crypts_of1.15222395
67MP0002132_abnormal_respiratory_system1.14529067
68MP0001851_eye_inflammation1.10463739
69MP0002277_abnormal_respiratory_mucosa1.07211024
70MP0008469_abnormal_protein_level1.07074161
71MP0001533_abnormal_skeleton_physiology1.03977867
72MP0000858_altered_metastatic_potential0.97038747
73MP0004883_abnormal_blood_vessel0.94397146
74MP0010094_abnormal_chromosome_stability0.94042349
75MP0004859_abnormal_synaptic_plasticity0.93095760
76MP0002019_abnormal_tumor_incidence0.92829223
77MP0010307_abnormal_tumor_latency0.84385422
78MP0008874_decreased_physiological_sensi0.84127657
79MP0008004_abnormal_stomach_pH0.80217104
80MP0003075_altered_response_to0.78665650
81MP0001968_abnormal_touch/_nociception0.78044859
82MP0001663_abnormal_digestive_system0.75548384
83MP0005390_skeleton_phenotype0.74558199
84MP0002736_abnormal_nociception_after0.71388144
85MP0005167_abnormal_blood-brain_barrier0.71269269
86MP0008569_lethality_at_weaning0.68871203
87MP0003656_abnormal_erythrocyte_physiolo0.68675161
88MP0002735_abnormal_chemical_nociception0.67820244
89MP0003448_altered_tumor_morphology0.67415072
90MP0000249_abnormal_blood_vessel0.65085187
91MP0003806_abnormal_nucleotide_metabolis0.64293281
92MP0002075_abnormal_coat/hair_pigmentati0.63834276
93MP0003329_amyloid_beta_deposits0.63680300
94MP0002693_abnormal_pancreas_physiology0.63538810
95MP0003795_abnormal_bone_structure0.62742590
96MP0000371_diluted_coat_color0.62641707
97MP0005164_abnormal_response_to0.62462187
98MP0001905_abnormal_dopamine_level0.62299510
99MP0002254_reproductive_system_inflammat0.61531614
100MP0000313_abnormal_cell_death0.60511779
101MP0003077_abnormal_cell_cycle0.59362923
102MP0000604_amyloidosis0.58648125
103MP0008058_abnormal_DNA_repair0.57925811
104MP0005166_decreased_susceptibility_to0.57221916
105MP0009765_abnormal_xenobiotic_induced0.56276518
106MP0009764_decreased_sensitivity_to0.56229541
107MP0002083_premature_death0.55671654
108MP0005381_digestive/alimentary_phenotyp0.55186863
109MP0000343_altered_response_to0.54631799
110MP0003111_abnormal_nucleus_morphology0.54073919
111MP0003690_abnormal_glial_cell0.53848556
112MP0008007_abnormal_cellular_replicative0.53361769
113MP0002064_seizures0.53327578
114MP0003191_abnormal_cellular_cholesterol0.52876522
115MP0005535_abnormal_body_temperature0.52296366
116MP0004381_abnormal_hair_follicle0.52043290
117MP0008873_increased_physiological_sensi0.51226290
118MP0009763_increased_sensitivity_to0.50557803
119MP0003943_abnormal_hepatobiliary_system0.50263038
120MP0009745_abnormal_behavioral_response0.50152765
121MP0003045_fibrosis0.48235464
122MP0004130_abnormal_muscle_cell0.48204964
123MP0000609_abnormal_liver_physiology0.48104415
124MP0003787_abnormal_imprinting0.47841827
125MP0003453_abnormal_keratinocyte_physiol0.46565393
126MP0002653_abnormal_ependyma_morphology0.46500088

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.30146825
2Agammaglobulinemia (HP:0004432)4.90234380
3Recurrent bacterial skin infections (HP:0005406)4.72008542
4IgM deficiency (HP:0002850)4.61523012
5Cellulitis (HP:0100658)4.52853939
6Chronic otitis media (HP:0000389)4.43319547
7Elevated erythrocyte sedimentation rate (HP:0003565)4.37648797
8Thyroiditis (HP:0100646)4.26222612
9Meningitis (HP:0001287)4.21335112
10Eczematoid dermatitis (HP:0000976)4.16776566
11Recurrent viral infections (HP:0004429)4.13524608
12Recurrent fungal infections (HP:0002841)4.06207550
13Panhypogammaglobulinemia (HP:0003139)3.97892491
14Myositis (HP:0100614)3.75582081
15Recurrent bronchitis (HP:0002837)3.75419421
16B lymphocytopenia (HP:0010976)3.73277310
17Abnormality of B cell number (HP:0010975)3.73277310
18Abnormality of glycolipid metabolism (HP:0010969)3.61155526
19Abnormality of liposaccharide metabolism (HP:0010968)3.61155526
20Abnormality of glycosphingolipid metabolism (HP:0004343)3.61155526
21Recurrent skin infections (HP:0001581)3.59038215
22Chronic obstructive pulmonary disease (HP:0006510)3.55498036
23Obstructive lung disease (HP:0006536)3.55498036
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.52055136
25Chronic mucocutaneous candidiasis (HP:0002728)3.46856702
26Recurrent cutaneous fungal infections (HP:0011370)3.46856702
27Gastrointestinal infarctions (HP:0005244)3.36890524
28Thrombocytosis (HP:0001894)3.28994688
29Abnormality of the fingertips (HP:0001211)3.26277366
30Spontaneous hematomas (HP:0007420)3.25847550
31Inflammation of the large intestine (HP:0002037)3.20378731
32Gastrointestinal inflammation (HP:0004386)3.17547301
33Osteomyelitis (HP:0002754)3.14715503
34Prolonged bleeding time (HP:0003010)3.14021447
35Verrucae (HP:0200043)3.11387659
36Papilloma (HP:0012740)3.11387659
37Vasculitis (HP:0002633)3.07193409
38Mediastinal lymphadenopathy (HP:0100721)3.06757190
39T lymphocytopenia (HP:0005403)3.05358772
40Stomatitis (HP:0010280)2.99882243
41Lymphopenia (HP:0001888)2.99852466
42Abnormality of macrophages (HP:0004311)2.97167212
43Abnormality of T cells (HP:0002843)2.96351628
44Dysostosis multiplex (HP:0000943)2.93621289
45Gastrointestinal stroma tumor (HP:0100723)2.93592142
46Urticaria (HP:0001025)2.91815651
47Abnormality of cells of the lymphoid lineage (HP:0012140)2.89257304
48Colitis (HP:0002583)2.88095003
49Abnormality of T cell number (HP:0011839)2.87718770
50Chronic sinusitis (HP:0011109)2.86094542
51Severe combined immunodeficiency (HP:0004430)2.85912743
52Sepsis (HP:0100806)2.79476617
53Recurrent pneumonia (HP:0006532)2.79289060
54Abnormality of T cell physiology (HP:0011840)2.78593832
55Recurrent sinusitis (HP:0011108)2.72678644
56IgG deficiency (HP:0004315)2.69772081
57Autoimmune thrombocytopenia (HP:0001973)2.67581251
58Keratoconjunctivitis (HP:0001096)2.62727419
59Eosinophilia (HP:0001880)2.60079576
60Petechiae (HP:0000967)2.59529028
61Epistaxis (HP:0000421)2.58541748
62Abnormality of eosinophils (HP:0001879)2.54608574
63Recurrent gram-negative bacterial infections (HP:0005420)2.53175259
64Gingivitis (HP:0000230)2.51159096
65Purpura (HP:0000979)2.49336202
66Leukocytosis (HP:0001974)2.48553049
67Increased IgE level (HP:0003212)2.47531077
68Optic neuritis (HP:0100653)2.47449846
69Retrobulbar optic neuritis (HP:0100654)2.47449846
70Increased IgM level (HP:0003496)2.46467395
71Acute lymphatic leukemia (HP:0006721)2.45911743
72Combined immunodeficiency (HP:0005387)2.45821353
73Chronic diarrhea (HP:0002028)2.45618575
74Systemic lupus erythematosus (HP:0002725)2.45036253
75Hypochromic anemia (HP:0001931)2.44334411
76Episodic fever (HP:0001954)2.43719288
77Hypoplasia of the thymus (HP:0000778)2.43436488
78Granulocytopenia (HP:0001913)2.43252397
79Recurrent lower respiratory tract infections (HP:0002783)2.39007439
80Abnormality of the prostate (HP:0008775)2.35923128
81Encephalitis (HP:0002383)2.35561104
82Increased serum ferritin (HP:0003281)2.35035805
83Lymphoma (HP:0002665)2.30286964
84Pulmonary embolism (HP:0002204)2.30038563
85Periodontitis (HP:0000704)2.29195298
86Chest pain (HP:0100749)2.29143827
87Nasal polyposis (HP:0100582)2.27426515
88Orchitis (HP:0100796)2.27092993
89Abnormality of mucopolysaccharide metabolism (HP:0011020)2.26303881
90Abnormality of polysaccharide metabolism (HP:0011012)2.26303881
91Abnormality of glycosaminoglycan metabolism (HP:0004371)2.26303881
92Papilledema (HP:0001085)2.24498026
93Increased cerebral lipofuscin (HP:0011813)2.24022123
94Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.23678642
95Hemoptysis (HP:0002105)2.22466110
96Interstitial pulmonary disease (HP:0006530)2.21814439
97Vacuolated lymphocytes (HP:0001922)2.21525024
98Increased neuronal autofluorescent lipopigment (HP:0002074)2.21155476
99Amyloidosis (HP:0011034)2.17851993
100IgA deficiency (HP:0002720)2.14479665
101Hepatosplenomegaly (HP:0001433)2.11171003
102Anorexia (HP:0002039)2.10343855
103Skin rash (HP:0000988)2.10055481
104Abnormality of iron homeostasis (HP:0011031)2.09235187
105Restrictive lung disease (HP:0002091)2.08586408
106Abnormality of the pleura (HP:0002103)2.07886331
107Hematochezia (HP:0002573)2.07549436
108Hypochromic microcytic anemia (HP:0004840)2.07156037
109Urinary glycosaminoglycan excretion (HP:0003541)2.05984255
110Mucopolysacchariduria (HP:0008155)2.05984255
111Hypergammaglobulinemia (HP:0010702)2.05970211
112Neutropenia (HP:0001875)2.05679593
113Abnormality of the nasal mucosa (HP:0000433)2.04709258
114Gingival bleeding (HP:0000225)2.04571610
115Slow saccadic eye movements (HP:0000514)2.04095586
116Pulmonary infiltrates (HP:0002113)2.03103776
117Mutism (HP:0002300)2.02059773
118Disinhibition (HP:0000734)2.01613746
119Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.00681173
120Neuronal loss in central nervous system (HP:0002529)1.98055016
121Premature loss of primary teeth (HP:0006323)1.94317196
122Keratoconjunctivitis sicca (HP:0001097)1.93986972
123Loss of speech (HP:0002371)1.93768013
124Skin ulcer (HP:0200042)1.93556515
125Pustule (HP:0200039)1.92591627
126Emphysema (HP:0002097)1.92336189
127Arterial thrombosis (HP:0004420)1.89952611
128Abnormal platelet function (HP:0011869)1.89948292
129Impaired platelet aggregation (HP:0003540)1.89948292
130Autoimmune hemolytic anemia (HP:0001890)1.86183244
131Leukopenia (HP:0001882)1.85582812
132Acute myeloid leukemia (HP:0004808)1.83764257
133Abnormality of DNA repair (HP:0003254)1.81058600

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.02345520
2FES3.01975662
3KIT3.01668063
4BLK2.90439832
5RIPK42.88865248
6IRAK42.84453099
7TXK2.57379435
8SYK2.55531913
9CSF1R2.48240036
10BTK2.43689746
11EEF2K2.40928696
12SIK22.33304054
13CLK12.11693788
14MAP3K132.00279909
15ZAP701.98979392
16MAP3K101.97631592
17GRK61.91167519
18TEC1.86186804
19MAP3K111.86038474
20TYK21.74848380
21JAK31.71282618
22TAOK11.69729481
23IKBKE1.69503673
24HCK1.66626444
25MAP3K141.63464581
26ITK1.56089190
27LCK1.53834619
28TAOK31.49902401
29TRIB31.44703298
30EPHB11.43549386
31FLT31.42339960
32MAP3K31.39434002
33LYN1.33541560
34TBK11.32703733
35CDK191.24425733
36SIK31.18288720
37JAK11.14807957
38MAP3K11.13327574
39STK101.07692162
40TESK21.06935743
41TAOK21.04553253
42MAP3K121.01161527
43MAP2K31.00895898
44TNK20.95209201
45ERN10.94972639
46CAMKK20.94451744
47IKBKB0.92233821
48FGFR30.91311509
49IRAK10.89138841
50SIK10.87081287
51SMG10.86841550
52IRAK20.83734317
53HIPK20.83010750
54CSK0.79463617
55DAPK10.78863003
56PRKCQ0.78132013
57CDC42BPA0.77600010
58TRPM70.74502805
59PIM10.73237041
60PRPF4B0.72383707
61KSR20.71527638
62MAPK40.70796520
63CCNB10.69333120
64MATK0.67577740
65ADRBK20.67390752
66TNIK0.66872890
67PRKCH0.66812402
68PDPK10.66382461
69DYRK1B0.66158515
70PTK60.65104029
71IRAK30.64636238
72PDK10.63506697
73FGFR20.61791560
74MAPKAPK50.61139130
75EPHA30.60795075
76CDK40.60304763
77BMPR20.57068667
78TGFBR20.56820744
79MAPK120.55764176
80BRD40.55201047
81MAP3K70.54473452
82STK160.53252422
83ATR0.52903646
84GRK70.52440964
85YES10.50984518
86STK40.50481337
87LRRK20.50139121
88KDR0.50079226
89PASK0.49782845
90NLK0.49435276
91JAK20.48617548
92UHMK10.48014452
93RPS6KA60.47701381
94MAP2K60.47383118
95MAPK70.47372604
96DAPK20.46265004
97FYN0.46101415
98NEK20.45792439
99TGFBR10.42668621
100ICK0.41895737
101MARK30.41227135
102PRKCD0.41145716
103STK110.41138343
104MAP3K60.40822780
105CAMKK10.40571501
106EIF2AK30.40530764
107FGFR40.40214563
108CDC70.39994778
109MAP2K20.39802900
110FRK0.39635783
111RPS6KA20.39039639
112RPS6KC10.37579587
113RPS6KL10.37579587
114SCYL20.36713651
115MARK20.36256865
116MAPK110.36096362
117CAMK40.35041765
118RET0.34694825
119MAP3K50.34208834
120CDK120.30813467
121CAMK10.30557302
122PIM20.30471165
123CHUK0.29907368
124FGR0.28860857
125BRSK10.27792681
126RPS6KB20.27104330
127PKN20.26682384
128PRKD20.26130006
129ABL10.25710565

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.28749596
2B cell receptor signaling pathway_Homo sapiens_hsa046623.18665702
3Leishmaniasis_Homo sapiens_hsa051402.48316781
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.44232779
5Autoimmune thyroid disease_Homo sapiens_hsa053202.40199483
6Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.13936111
7Osteoclast differentiation_Homo sapiens_hsa043802.13728105
8DNA replication_Homo sapiens_hsa030302.07146213
9Intestinal immune network for IgA production_Homo sapiens_hsa046721.99879518
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.93907306
11Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.93604570
12Hematopoietic cell lineage_Homo sapiens_hsa046401.93243807
13Measles_Homo sapiens_hsa051621.88354388
14T cell receptor signaling pathway_Homo sapiens_hsa046601.87222897
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77918428
16Non-homologous end-joining_Homo sapiens_hsa034501.62609158
17Chemokine signaling pathway_Homo sapiens_hsa040621.59308136
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.52765713
19Base excision repair_Homo sapiens_hsa034101.48685220
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44507638
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.43044226
22Mismatch repair_Homo sapiens_hsa034301.39662359
23Antigen processing and presentation_Homo sapiens_hsa046121.38119436
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.35273600
25Acute myeloid leukemia_Homo sapiens_hsa052211.34574563
26Platelet activation_Homo sapiens_hsa046111.33314272
27Tuberculosis_Homo sapiens_hsa051521.33188179
28Pertussis_Homo sapiens_hsa051331.29501775
29Other glycan degradation_Homo sapiens_hsa005111.28509715
30Shigellosis_Homo sapiens_hsa051311.26571073
31Allograft rejection_Homo sapiens_hsa053301.25621293
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.23328291
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22474660
34Herpes simplex infection_Homo sapiens_hsa051681.19685896
35Non-small cell lung cancer_Homo sapiens_hsa052231.14836694
36Hepatitis B_Homo sapiens_hsa051611.09889065
37Influenza A_Homo sapiens_hsa051641.09858739
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.08830364
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07485443
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.07090856
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.05653698
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05573870
43Asthma_Homo sapiens_hsa053101.04978405
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04708950
45Chronic myeloid leukemia_Homo sapiens_hsa052201.02338453
46Salmonella infection_Homo sapiens_hsa051320.99956779
47Homologous recombination_Homo sapiens_hsa034400.99486949
48Toxoplasmosis_Homo sapiens_hsa051450.97217018
49Graft-versus-host disease_Homo sapiens_hsa053320.95601706
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93812049
51Apoptosis_Homo sapiens_hsa042100.89813638
52Pancreatic cancer_Homo sapiens_hsa052120.87708070
53Lysosome_Homo sapiens_hsa041420.87705573
54VEGF signaling pathway_Homo sapiens_hsa043700.85913456
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85661204
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84565409
57Sphingolipid signaling pathway_Homo sapiens_hsa040710.83305963
58Olfactory transduction_Homo sapiens_hsa047400.82399419
59Malaria_Homo sapiens_hsa051440.82216084
60African trypanosomiasis_Homo sapiens_hsa051430.80254645
61Inositol phosphate metabolism_Homo sapiens_hsa005620.77299643
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73999019
63TNF signaling pathway_Homo sapiens_hsa046680.71758427
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70753517
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69132996
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68574194
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68451590
68Morphine addiction_Homo sapiens_hsa050320.68142723
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66938049
70Rheumatoid arthritis_Homo sapiens_hsa053230.66612383
71Renal cell carcinoma_Homo sapiens_hsa052110.63770046
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.63397943
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62991782
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.62990424
75Legionellosis_Homo sapiens_hsa051340.62814750
76Hepatitis C_Homo sapiens_hsa051600.62644241
77Epstein-Barr virus infection_Homo sapiens_hsa051690.62355680
78Collecting duct acid secretion_Homo sapiens_hsa049660.62089457
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61033394
80Glioma_Homo sapiens_hsa052140.60592207
81Staphylococcus aureus infection_Homo sapiens_hsa051500.60102331
82Nucleotide excision repair_Homo sapiens_hsa034200.59551204
83mTOR signaling pathway_Homo sapiens_hsa041500.59466247
84Phagosome_Homo sapiens_hsa041450.58715657
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57728456
86Ribosome_Homo sapiens_hsa030100.54526602
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54103707
88GnRH signaling pathway_Homo sapiens_hsa049120.53647531
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53313020
90FoxO signaling pathway_Homo sapiens_hsa040680.53201968
91Type I diabetes mellitus_Homo sapiens_hsa049400.53017978
92Viral myocarditis_Homo sapiens_hsa054160.52326057
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51048936
94Choline metabolism in cancer_Homo sapiens_hsa052310.50891779
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.48794366
96HTLV-I infection_Homo sapiens_hsa051660.48469408
97N-Glycan biosynthesis_Homo sapiens_hsa005100.48112677
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47472314
99Endometrial cancer_Homo sapiens_hsa052130.47376693
100MAPK signaling pathway_Homo sapiens_hsa040100.47325084
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46727125
102Colorectal cancer_Homo sapiens_hsa052100.46160118
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45769105
104Fanconi anemia pathway_Homo sapiens_hsa034600.45682272
105Long-term potentiation_Homo sapiens_hsa047200.45496879
106Endocytosis_Homo sapiens_hsa041440.43944769
107Regulation of autophagy_Homo sapiens_hsa041400.43834910
108HIF-1 signaling pathway_Homo sapiens_hsa040660.43342389
109Prolactin signaling pathway_Homo sapiens_hsa049170.43258817
110Insulin resistance_Homo sapiens_hsa049310.41866294
111Notch signaling pathway_Homo sapiens_hsa043300.40397007
112Spliceosome_Homo sapiens_hsa030400.39296907
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39204521
114Viral carcinogenesis_Homo sapiens_hsa052030.38452634
115Type II diabetes mellitus_Homo sapiens_hsa049300.37886283
116Amoebiasis_Homo sapiens_hsa051460.33215009
117Dorso-ventral axis formation_Homo sapiens_hsa043200.31658730
118ErbB signaling pathway_Homo sapiens_hsa040120.31205566
119Systemic lupus erythematosus_Homo sapiens_hsa053220.28510458
120Rap1 signaling pathway_Homo sapiens_hsa040150.27896636

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