CORT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of synaptic transmission, dopaminergic (GO:0032226)6.55866359
2regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)6.33139424
3NADH metabolic process (GO:0006734)6.22514338
4L-methionine biosynthetic process from methylthioadenosine (GO:0019509)5.72995164
5aggressive behavior (GO:0002118)5.56337812
6pyrimidine nucleobase catabolic process (GO:0006208)5.47747954
7succinate metabolic process (GO:0006105)5.44809409
8regulation of glutamate receptor signaling pathway (GO:1900449)5.31711896
9synaptic vesicle exocytosis (GO:0016079)5.28015938
10oxaloacetate metabolic process (GO:0006107)5.25677244
11energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)5.18725185
12ATP hydrolysis coupled proton transport (GO:0015991)5.18725185
13negative regulation of synaptic transmission, GABAergic (GO:0032229)5.17413593
14vocalization behavior (GO:0071625)5.16993648
15transferrin transport (GO:0033572)5.09849203
16gamma-aminobutyric acid transport (GO:0015812)5.09139089
17glutamate secretion (GO:0014047)4.82223092
18protein-cofactor linkage (GO:0018065)4.77927924
19glycosphingolipid biosynthetic process (GO:0006688)4.77171885
20regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.76593892
21regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.76593892
22ferric iron transport (GO:0015682)4.73253638
23trivalent inorganic cation transport (GO:0072512)4.73253638
24regulation of short-term neuronal synaptic plasticity (GO:0048172)4.70560544
25L-methionine salvage (GO:0071267)4.70268320
26L-methionine biosynthetic process (GO:0071265)4.70268320
27amino acid salvage (GO:0043102)4.70268320
28neurotransmitter secretion (GO:0007269)4.65923282
29nucleobase catabolic process (GO:0046113)4.55012806
30regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.51694490
31positive regulation of synaptic transmission, GABAergic (GO:0032230)4.50406523
32behavioral response to ethanol (GO:0048149)4.46462145
33neuron-neuron synaptic transmission (GO:0007270)4.46400081
34positive regulation of action potential (GO:0045760)4.44362620
35neuronal action potential propagation (GO:0019227)4.39628409
36regulation of synaptic transmission, dopaminergic (GO:0032225)4.37649918
37regulation of neurotransmitter uptake (GO:0051580)4.37623984
38substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.34338722
39substrate-independent telencephalic tangential migration (GO:0021826)4.34338722
40regulation of synaptic vesicle exocytosis (GO:2000300)4.33535807
41positive regulation of vesicle fusion (GO:0031340)4.30824454
42neuron cell-cell adhesion (GO:0007158)4.29680285
43tricarboxylic acid cycle (GO:0006099)4.26558860
44regulation of synapse structural plasticity (GO:0051823)4.22865669
45startle response (GO:0001964)4.15016909
46positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.13819053
47peptidyl-cysteine modification (GO:0018198)4.13802336
48regulation of synaptic transmission, GABAergic (GO:0032228)4.12487569
49regulation of vesicle fusion (GO:0031338)4.10405991
50neurotransmitter-gated ion channel clustering (GO:0072578)4.06386888
51regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.05761251
52gamma-aminobutyric acid signaling pathway (GO:0007214)4.03077671
53ionotropic glutamate receptor signaling pathway (GO:0035235)3.99379146
54synaptic transmission, glutamatergic (GO:0035249)3.98017110
55regulation of response to food (GO:0032095)3.96302245
56phagosome maturation (GO:0090382)3.95531322
57cellular response to ammonium ion (GO:0071242)3.88496499
58synaptic transmission, dopaminergic (GO:0001963)3.86801068
59mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.84616930
60positive regulation of amino acid transport (GO:0051957)3.82566543
61positive regulation of neurotransmitter transport (GO:0051590)3.81252424
62locomotory exploration behavior (GO:0035641)3.78771944
63dicarboxylic acid catabolic process (GO:0043649)3.77587990
64positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.76467151
65membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.74577998
66synaptic vesicle docking involved in exocytosis (GO:0016081)3.73103902
67cell migration in hindbrain (GO:0021535)3.72151247
68synaptic vesicle maturation (GO:0016188)3.71022017
69regulation of synaptic vesicle transport (GO:1902803)3.70725845
70amino acid import (GO:0043090)3.70010038
71presynaptic membrane assembly (GO:0097105)3.67273559
72long-term memory (GO:0007616)3.66006165
73positive regulation of dendritic spine morphogenesis (GO:0061003)3.63820639
74positive regulation of amine transport (GO:0051954)3.62062984
75chaperone-mediated protein transport (GO:0072321)3.55806146
76postsynaptic membrane organization (GO:0001941)3.55278445
77neurofilament cytoskeleton organization (GO:0060052)3.53021483
78cullin deneddylation (GO:0010388)3.50926171
79proline transport (GO:0015824)3.50066952
80glycine transport (GO:0015816)3.49037610
81protein localization to synapse (GO:0035418)3.45596544
82neurotransmitter biosynthetic process (GO:0042136)3.45541227
83ATP synthesis coupled proton transport (GO:0015986)3.44668829
84energy coupled proton transport, down electrochemical gradient (GO:0015985)3.44668829
85presynaptic membrane organization (GO:0097090)3.40070830
86positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.39274387
87establishment of mitochondrion localization (GO:0051654)3.37791377
88neurotransmitter transport (GO:0006836)3.36799055
89L-serine transport (GO:0015825)3.36348697
90striatum development (GO:0021756)3.35717055
91mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.34808604
92glutamate receptor signaling pathway (GO:0007215)3.34782334
93regulation of long-term neuronal synaptic plasticity (GO:0048169)3.33281401
94response to cocaine (GO:0042220)3.33250317
95regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.32038656
96regulation of neurotransmitter levels (GO:0001505)3.31815853
97long-term synaptic potentiation (GO:0060291)3.31110051
98short-term memory (GO:0007614)3.31002559
99response to dietary excess (GO:0002021)3.30104559
100exogenous drug catabolic process (GO:0042738)3.29387634
101synaptic vesicle endocytosis (GO:0048488)3.24586907
102sialylation (GO:0097503)3.22960817
103response to lead ion (GO:0010288)3.20346666
104establishment of synaptic vesicle localization (GO:0097480)3.20332227
105synaptic vesicle transport (GO:0048489)3.20332227
106positive regulation of mitochondrial fission (GO:0090141)3.20290796
107mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.16702895
108protein insertion into membrane (GO:0051205)3.15770257
109adult feeding behavior (GO:0008343)3.12856740
110acidic amino acid transport (GO:0015800)3.09913987
111neuromuscular process controlling posture (GO:0050884)3.08987087
112activation of protein kinase A activity (GO:0034199)3.08201208
113negative regulation of dendrite morphogenesis (GO:0050774)3.07320464
114cerebellar Purkinje cell differentiation (GO:0021702)3.07310083
115protein complex biogenesis (GO:0070271)3.04562513
116regulation of neurotransmitter transport (GO:0051588)3.03451641
117regulation of neuronal synaptic plasticity (GO:0048168)3.03301712
118positive regulation of synapse assembly (GO:0051965)3.02876167
119exploration behavior (GO:0035640)3.01715345
120glutamine family amino acid catabolic process (GO:0009065)3.00932194
121positive regulation of synapse maturation (GO:0090129)3.00549686
122positive regulation of synaptic transmission (GO:0050806)3.00518198
123* synaptic transmission (GO:0007268)3.00239324
124regulation of appetite (GO:0032098)2.99551404
125regulation of action potential (GO:0098900)2.97453507
126protein deneddylation (GO:0000338)2.97357347
127negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.96465531
128regulation of dendritic spine morphogenesis (GO:0061001)2.94020252
129positive regulation of membrane potential (GO:0045838)2.93856686
130regulation of mitochondrial fission (GO:0090140)2.87276592
131methionine biosynthetic process (GO:0009086)2.84429647
132serine transport (GO:0032329)2.79048334
133establishment of vesicle localization (GO:0051650)2.78088427
134negative regulation of receptor activity (GO:2000272)2.77565655
135iron-sulfur cluster assembly (GO:0016226)2.76264248
136metallo-sulfur cluster assembly (GO:0031163)2.76264248
137regulation of amino acid transport (GO:0051955)2.75837408
138regulation of mitochondrial translation (GO:0070129)2.73808098
139glycolipid biosynthetic process (GO:0009247)2.73698345
140synapse assembly (GO:0007416)2.73042991
141polyamine metabolic process (GO:0006595)2.71406811
142aspartate family amino acid biosynthetic process (GO:0009067)2.68401461
143preassembly of GPI anchor in ER membrane (GO:0016254)2.68350215
144regulation of protein kinase A signaling (GO:0010738)2.67995199
145anterograde synaptic vesicle transport (GO:0048490)2.67480781
146neuromuscular synaptic transmission (GO:0007274)2.65700114
147melanosome transport (GO:0032402)2.64331769
148establishment of melanosome localization (GO:0032401)2.59947686
149regulation of synapse maturation (GO:0090128)2.59557151
150protein localization to cilium (GO:0061512)2.56957326
151nonmotile primary cilium assembly (GO:0035058)2.55844407
152neurotransmitter metabolic process (GO:0042133)2.54682448
153ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.54635953

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.01880799
2GBX2_23144817_ChIP-Seq_PC3_Human4.94666779
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.76239051
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.20920166
5TAF15_26573619_Chip-Seq_HEK293_Human3.13130148
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89024429
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77957682
8REST_21632747_ChIP-Seq_MESCs_Mouse2.69969981
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.67331693
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.57812086
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48701722
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48585740
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.46879581
14REST_18959480_ChIP-ChIP_MESCs_Mouse2.45079150
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.44718788
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.44427759
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42097238
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40013715
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.36762669
20ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.33892922
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.31653494
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.31508654
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.31177065
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.29502505
25AR_21572438_ChIP-Seq_LNCaP_Human2.23939211
26EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22352006
27RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22352006
28GABP_17652178_ChIP-ChIP_JURKAT_Human2.20343924
29ETS1_20019798_ChIP-Seq_JURKAT_Human2.15138380
30RARB_27405468_Chip-Seq_BRAIN_Mouse2.13187010
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12842009
32CREB1_15753290_ChIP-ChIP_HEK293T_Human2.10396971
33EED_16625203_ChIP-ChIP_MESCs_Mouse2.07458273
34SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.07303693
35SRY_22984422_ChIP-ChIP_TESTIS_Rat2.05582276
36MTF2_20144788_ChIP-Seq_MESCs_Mouse2.03285827
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.97300427
38IGF1R_20145208_ChIP-Seq_DFB_Human1.95482406
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90873186
40EST1_17652178_ChIP-ChIP_JURKAT_Human1.87668466
41SMAD4_21799915_ChIP-Seq_A2780_Human1.78313653
42P300_19829295_ChIP-Seq_ESCs_Human1.76432663
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75810905
44VDR_22108803_ChIP-Seq_LS180_Human1.74727828
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.74683891
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.72942605
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72283468
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.71795673
49DROSHA_22980978_ChIP-Seq_HELA_Human1.70084005
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68874628
51GABP_19822575_ChIP-Seq_HepG2_Human1.65353676
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63790513
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.58414136
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57455685
55ER_23166858_ChIP-Seq_MCF-7_Human1.56957666
56PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.54950031
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54249492
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.54159645
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53914071
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53856066
61* FUS_26573619_Chip-Seq_HEK293_Human1.52612013
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51239931
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50156327
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47402112
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.46091602
66RNF2_27304074_Chip-Seq_NSC_Mouse1.42837428
67SOX2_21211035_ChIP-Seq_LN229_Gbm1.37737183
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36884906
69TP53_22573176_ChIP-Seq_HFKS_Human1.36860777
70SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.36510907
71VDR_23849224_ChIP-Seq_CD4+_Human1.35425609
72AR_25329375_ChIP-Seq_VCAP_Human1.34890751
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34758281
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.33616129
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33185991
76JUN_21703547_ChIP-Seq_K562_Human1.29050568
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.28756904
78SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.26558037
79DCP1A_22483619_ChIP-Seq_HELA_Human1.25624370
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23175764
81XRN2_22483619_ChIP-Seq_HELA_Human1.22581879
82CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22431419
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.21990858
84STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21623374
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21578684
86CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.21214722
87NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20538395
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19141758
89CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18058446
90RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17739124
91RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.17566094
92CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16818210
93TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.15575197
94ZNF274_21170338_ChIP-Seq_K562_Hela1.13764063
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12640501
96SRF_21415370_ChIP-Seq_HL-1_Mouse1.11932306
97STAT3_23295773_ChIP-Seq_U87_Human1.11641277
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11122984
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10568792
100KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.09666872
101RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08688847
102PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06845735
103MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06495873
104PRDM14_20953172_ChIP-Seq_ESCs_Human1.05641265
105CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05592418
106ARNT_22903824_ChIP-Seq_MCF-7_Human1.05268113
107CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.04725128
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01570126
109POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00824425
110RUNX2_22187159_ChIP-Seq_PCA_Human1.00816193
111RING1B_27294783_Chip-Seq_ESCs_Mouse1.00647520
112TCF4_23295773_ChIP-Seq_U87_Human0.99406422
113YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98812297
114SOX9_26525672_Chip-Seq_HEART_Mouse0.98142259
115FLI1_27457419_Chip-Seq_LIVER_Mouse0.97673268
116HTT_18923047_ChIP-ChIP_STHdh_Human0.97004534
117ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96671516
118YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96646966
119* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96069882
120MYC_19829295_ChIP-Seq_ESCs_Human0.94565633
121FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94374188
122E2F1_17053090_ChIP-ChIP_MCF-7_Human0.93660022
123TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93387661
124AHR_22903824_ChIP-Seq_MCF-7_Human0.93210226
125CIITA_25753668_ChIP-Seq_RAJI_Human0.92358346
126AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91806944
127CBP_20019798_ChIP-Seq_JUKART_Human0.91258489
128IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91258489
129IRF1_19129219_ChIP-ChIP_H3396_Human0.87707193
130NANOG_18555785_Chip-Seq_ESCs_Mouse0.87217250
131POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86789032
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86789032
133AR_19668381_ChIP-Seq_PC3_Human0.86624492
134YY1_21170310_ChIP-Seq_MESCs_Mouse0.86479009
135CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85840575
136CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85607730
137* FOXP3_21729870_ChIP-Seq_TREG_Human0.85100212
138REST_19997604_ChIP-ChIP_NEURONS_Mouse0.84782573
139MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84151124
140TTF2_22483619_ChIP-Seq_HELA_Human0.80947948
141FOXP1_21924763_ChIP-Seq_HESCs_Human0.79971921

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.27277194
2MP0009046_muscle_twitch4.22605775
3MP0003635_abnormal_synaptic_transmissio3.72912444
4MP0003880_abnormal_central_pattern3.53683395
5MP0003787_abnormal_imprinting3.53171491
6MP0002064_seizures3.41552090
7MP0009745_abnormal_behavioral_response3.34225026
8MP0002736_abnormal_nociception_after2.94343634
9MP0002063_abnormal_learning/memory/cond2.93653994
10MP0002272_abnormal_nervous_system2.92020675
11MP0003646_muscle_fatigue2.89993082
12MP0005645_abnormal_hypothalamus_physiol2.88524255
13MP0002572_abnormal_emotion/affect_behav2.79621225
14MP0003122_maternal_imprinting2.74900863
15MP0001968_abnormal_touch/_nociception2.62270233
16MP0001529_abnormal_vocalization2.60909821
17MP0005646_abnormal_pituitary_gland2.49565464
18MP0002735_abnormal_chemical_nociception2.43117234
19MP0001501_abnormal_sleep_pattern2.35591118
20MP0004270_analgesia2.16679114
21MP0008877_abnormal_DNA_methylation2.11830118
22MP0001486_abnormal_startle_reflex2.09192636
23MP0002734_abnormal_mechanical_nocicepti2.02049766
24MP0001986_abnormal_taste_sensitivity1.86672333
25MP0004858_abnormal_nervous_system1.85135975
26MP0004233_abnormal_muscle_weight1.80449737
27MP0001970_abnormal_pain_threshold1.76488193
28MP0001440_abnormal_grooming_behavior1.69305660
29MP0004142_abnormal_muscle_tone1.67646057
30MP0002067_abnormal_sensory_capabilities1.63161149
31MP0002837_dystrophic_cardiac_calcinosis1.62545316
32MP0005423_abnormal_somatic_nervous1.61861505
33MP0009780_abnormal_chondrocyte_physiolo1.58961765
34MP0002557_abnormal_social/conspecific_i1.57732891
35MP0003121_genomic_imprinting1.54532341
36MP0002733_abnormal_thermal_nociception1.54114743
37MP0004811_abnormal_neuron_physiology1.54053916
38MP0004043_abnormal_pH_regulation1.49052036
39MP0002184_abnormal_innervation1.48300784
40MP0002822_catalepsy1.48191922
41MP0005386_behavior/neurological_phenoty1.47118205
42MP0004924_abnormal_behavior1.47118205
43MP0001984_abnormal_olfaction1.46926737
44MP0000013_abnormal_adipose_tissue1.37661785
45MP0006292_abnormal_olfactory_placode1.36502448
46MP0001502_abnormal_circadian_rhythm1.35897860
47MP0002102_abnormal_ear_morphology1.35110894
48MP0002876_abnormal_thyroid_physiology1.33156922
49MP0000778_abnormal_nervous_system1.30717489
50MP0006276_abnormal_autonomic_nervous1.30366300
51MP0005171_absent_coat_pigmentation1.29798668
52MP0000751_myopathy1.29000813
53MP0002234_abnormal_pharynx_morphology1.28936084
54MP0000955_abnormal_spinal_cord1.28185350
55MP0002066_abnormal_motor_capabilities/c1.26051423
56MP0005084_abnormal_gallbladder_morpholo1.23196193
57MP0005499_abnormal_olfactory_system1.22463621
58MP0005394_taste/olfaction_phenotype1.22463621
59MP0008569_lethality_at_weaning1.19921825
60MP0003879_abnormal_hair_cell1.18123714
61MP0002882_abnormal_neuron_morphology1.17550043
62MP0004484_altered_response_of1.14461397
63MP0001188_hyperpigmentation1.10768435
64MP0003123_paternal_imprinting1.10249669
65MP0004084_abnormal_cardiac_muscle1.08821342
66MP0008058_abnormal_DNA_repair1.08520357
67MP0002638_abnormal_pupillary_reflex1.07498093
68MP0004036_abnormal_muscle_relaxation1.06118315
69MP0008872_abnormal_physiological_respon1.02087749
70MP0000631_abnormal_neuroendocrine_gland1.00681358
71MP0005623_abnormal_meninges_morphology1.00473409
72MP0003329_amyloid_beta_deposits0.99813887
73MP0002152_abnormal_brain_morphology0.99728606
74MP0004147_increased_porphyrin_level0.99293276
75MP0002653_abnormal_ependyma_morphology0.97862945
76MP0006035_abnormal_mitochondrial_morpho0.97527029
77MP0001905_abnormal_dopamine_level0.97485047
78MP0004215_abnormal_myocardial_fiber0.96816949
79MP0000566_synostosis0.92305274
80MP0005253_abnormal_eye_physiology0.91804243
81MP0003718_maternal_effect0.90716707
82MP0001664_abnormal_digestion0.89989400
83MP0004085_abnormal_heartbeat0.88133964
84MP0000049_abnormal_middle_ear0.85059898
85MP0008875_abnormal_xenobiotic_pharmacok0.84906331
86MP0002069_abnormal_eating/drinking_beha0.84046071
87MP0001963_abnormal_hearing_physiology0.83263067
88MP0001177_atelectasis0.83157053
89MP0003221_abnormal_cardiomyocyte_apopto0.83015640
90MP0003183_abnormal_peptide_metabolism0.79182069
91MP0008775_abnormal_heart_ventricle0.78988624
92MP0003385_abnormal_body_wall0.77669910
93MP0001270_distended_abdomen0.77641429
94MP0008789_abnormal_olfactory_epithelium0.75038177
95MP0006036_abnormal_mitochondrial_physio0.74580519
96MP0008995_early_reproductive_senescence0.73976344
97MP0000604_amyloidosis0.73220069
98MP0000639_abnormal_adrenal_gland0.72506153
99MP0002160_abnormal_reproductive_system0.71815414
100MP0000750_abnormal_muscle_regeneration0.69433093
101MP0006138_congestive_heart_failure0.69269537
102MP0003938_abnormal_ear_development0.69215632
103MP0003137_abnormal_impulse_conducting0.69141529
104MP0002751_abnormal_autonomic_nervous0.68752065
105MP0003698_abnormal_male_reproductive0.68705788
106MP0003631_nervous_system_phenotype0.67665142
107MP0002332_abnormal_exercise_endurance0.67479186
108MP0001764_abnormal_homeostasis0.66522114
109MP0003632_abnormal_nervous_system0.65806721
110MP0004742_abnormal_vestibular_system0.65621747
111MP0002752_abnormal_somatic_nervous0.65424040
112MP0002909_abnormal_adrenal_gland0.64575510
113MP0005551_abnormal_eye_electrophysiolog0.62570402
114MP0004883_abnormal_blood_vessel0.61604660
115MP0003119_abnormal_digestive_system0.61072536
116MP0002928_abnormal_bile_duct0.60751460
117MP0002229_neurodegeneration0.60535441
118MP0008874_decreased_physiological_sensi0.59123303
119MP0001943_abnormal_respiration0.56978165
120MP0000026_abnormal_inner_ear0.56695826
121MP0004885_abnormal_endolymph0.56623346
122MP0010770_preweaning_lethality0.56130213
123MP0002082_postnatal_lethality0.56130213
124MP0000467_abnormal_esophagus_morphology0.56008273
125MP0003633_abnormal_nervous_system0.53958731

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.19915993
2Atonic seizures (HP:0010819)6.45048259
3Myokymia (HP:0002411)5.24082504
4Febrile seizures (HP:0002373)5.12281659
5Abnormal hair whorl (HP:0010721)4.88712258
6Epileptic encephalopathy (HP:0200134)4.79716556
7Acute necrotizing encephalopathy (HP:0006965)4.64915693
8Abnormality of the labia minora (HP:0012880)4.62193082
9Abnormal mitochondria in muscle tissue (HP:0008316)4.55996730
10Focal seizures (HP:0007359)4.45089726
11Absence seizures (HP:0002121)4.19053373
12Abnormality of glycolysis (HP:0004366)4.04466094
13Increased serum pyruvate (HP:0003542)4.04466094
14Neuroendocrine neoplasm (HP:0100634)4.01198283
15Pheochromocytoma (HP:0002666)3.97083947
16Polyphagia (HP:0002591)3.92376726
17Progressive macrocephaly (HP:0004481)3.86255665
18Mitochondrial inheritance (HP:0001427)3.80508214
19Ankle clonus (HP:0011448)3.74626099
20Oligomenorrhea (HP:0000876)3.70397430
21Poor suck (HP:0002033)3.68264576
22Cerebral hypomyelination (HP:0006808)3.66901562
23Generalized tonic-clonic seizures (HP:0002069)3.63988978
24Hyperventilation (HP:0002883)3.60102548
25Acute encephalopathy (HP:0006846)3.58212476
26Dialeptic seizures (HP:0011146)3.56377202
27Visual hallucinations (HP:0002367)3.55499617
28Failure to thrive in infancy (HP:0001531)3.50571768
29Hepatocellular necrosis (HP:0001404)3.47108247
30Progressive cerebellar ataxia (HP:0002073)3.42941834
31Increased CSF lactate (HP:0002490)3.42735238
32Delusions (HP:0000746)3.36756033
33Split foot (HP:0001839)3.14938580
34Urinary urgency (HP:0000012)3.13506391
35Retinal dysplasia (HP:0007973)3.10952664
36Neoplasm of the peripheral nervous system (HP:0100007)3.10652005
37Abnormal eating behavior (HP:0100738)3.10538943
38Resting tremor (HP:0002322)3.07545354
39Progressive inability to walk (HP:0002505)2.98901799
40Gait imbalance (HP:0002141)2.94948969
41Epileptiform EEG discharges (HP:0011182)2.84147812
42Narrow nasal bridge (HP:0000446)2.82557585
43Hypsarrhythmia (HP:0002521)2.72286195
44EEG with generalized epileptiform discharges (HP:0011198)2.69528144
45Specific learning disability (HP:0001328)2.66830271
46Sleep apnea (HP:0010535)2.65117647
47Medial flaring of the eyebrow (HP:0010747)2.64734494
48Upper limb muscle weakness (HP:0003484)2.64681091
49Abnormality of binocular vision (HP:0011514)2.64574328
50Diplopia (HP:0000651)2.64574328
51Action tremor (HP:0002345)2.64068351
52Congenital primary aphakia (HP:0007707)2.63909216
53Leukodystrophy (HP:0002415)2.62348480
54Generalized hypotonia (HP:0001290)2.61441064
55Spastic gait (HP:0002064)2.61269493
563-Methylglutaconic aciduria (HP:0003535)2.56029552
57Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.54270420
58Decreased activity of mitochondrial respiratory chain (HP:0008972)2.54270420
59Amyotrophic lateral sclerosis (HP:0007354)2.51706877
60Nephrogenic diabetes insipidus (HP:0009806)2.49151747
61Spastic diplegia (HP:0001264)2.49007774
62Inability to walk (HP:0002540)2.44127761
63Hepatic necrosis (HP:0002605)2.43770246
64Cerebral edema (HP:0002181)2.40177174
65Optic disc pallor (HP:0000543)2.39283103
66Methylmalonic aciduria (HP:0012120)2.37774395
67Thyroid-stimulating hormone excess (HP:0002925)2.34673557
68Abnormal gallbladder physiology (HP:0012438)2.30528048
69Cholecystitis (HP:0001082)2.30528048
70Lissencephaly (HP:0001339)2.28094936
71Impaired pain sensation (HP:0007328)2.27135717
72Abnormality of pain sensation (HP:0010832)2.27135717
73Methylmalonic acidemia (HP:0002912)2.26855722
74Type II lissencephaly (HP:0007260)2.25916134
75Impaired vibration sensation in the lower limbs (HP:0002166)2.25538779
76Respiratory failure (HP:0002878)2.24716128
77Broad-based gait (HP:0002136)2.23847170
78Aplasia/Hypoplasia of the brainstem (HP:0007362)2.23075285
79Hypoplasia of the brainstem (HP:0002365)2.23075285
80Shoulder girdle muscle weakness (HP:0003547)2.21352107
81Dysdiadochokinesis (HP:0002075)2.19793402
82Abnormality of the hip-girdle musculature (HP:0001445)2.19206666
83Abnormality of the musculature of the pelvis (HP:0001469)2.19206666
84Opisthotonus (HP:0002179)2.17951481
85Abnormality of alanine metabolism (HP:0010916)2.17619999
86Hyperalaninemia (HP:0003348)2.17619999
87Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.17619999
88Facial hemangioma (HP:0000329)2.17020707
89Lipid accumulation in hepatocytes (HP:0006561)2.14374205
90CNS hypomyelination (HP:0003429)2.13731025
91Blue irides (HP:0000635)2.13685049
92Progressive microcephaly (HP:0000253)2.13370136
93Esotropia (HP:0000565)2.12860435
94Clonus (HP:0002169)2.12569420
95Intention tremor (HP:0002080)2.12454287
96Exercise intolerance (HP:0003546)2.10732788
97Focal dystonia (HP:0004373)2.10230526
98Hip dysplasia (HP:0001385)2.10005626
99Truncal ataxia (HP:0002078)2.07526490
100Pendular nystagmus (HP:0012043)2.06292541
101Neoplasm of head and neck (HP:0012288)2.04687284
102Esophageal neoplasm (HP:0100751)2.04687284
103Generalized myoclonic seizures (HP:0002123)2.04533606
104CNS demyelination (HP:0007305)2.04343879
105Atrophy/Degeneration involving motor neurons (HP:0007373)2.03360295
106Ragged-red muscle fibers (HP:0003200)2.02873648
107Increased hepatocellular lipid droplets (HP:0006565)2.01457274
108Abnormality of the astrocytes (HP:0100707)2.01363059
109Astrocytoma (HP:0009592)2.01363059
110Excessive salivation (HP:0003781)2.00389025
111Drooling (HP:0002307)2.00389025
112Poor coordination (HP:0002370)1.99983297
113Long foot (HP:0001833)1.99747137
114Labial hypoplasia (HP:0000066)1.99711522
115Torticollis (HP:0000473)1.98960534
116Emotional lability (HP:0000712)1.97865545
117Spastic tetraplegia (HP:0002510)1.97255768
118Hand muscle atrophy (HP:0009130)1.96378690
119Lactic acidosis (HP:0003128)1.96295319
120Decreased testicular size (HP:0008734)1.96107942
121Mutism (HP:0002300)1.95660657
122Abnormality of the vocal cords (HP:0008777)1.95648460
123Impaired social interactions (HP:0000735)1.93572643
124Abnormal social behavior (HP:0012433)1.93572643
125Bony spicule pigmentary retinopathy (HP:0007737)1.93529621
126Postnatal microcephaly (HP:0005484)1.92686309
127Scanning speech (HP:0002168)1.91812649
128Lower limb muscle weakness (HP:0007340)1.91364478
129Vaginal atresia (HP:0000148)1.90622141
130X-linked dominant inheritance (HP:0001423)1.90485350
131Severe global developmental delay (HP:0011344)1.90185827
132Paraplegia (HP:0010550)1.90106128
133Delayed CNS myelination (HP:0002188)1.89976129
134Gout (HP:0001997)1.89678083
135Amblyopia (HP:0000646)1.88840721
136Hemiplegia (HP:0002301)1.87910826
137Anxiety (HP:0000739)1.87357355
138Increased serum lactate (HP:0002151)1.87098348
139Status epilepticus (HP:0002133)1.86817316
140Progressive external ophthalmoplegia (HP:0000590)1.84947949
141Depression (HP:0000716)1.84855908
142Gaze-evoked nystagmus (HP:0000640)1.83571793
143Hypoplastic female external genitalia (HP:0012815)1.83480304
144Hypoventilation (HP:0002791)1.83163994
145Generalized hypopigmentation (HP:0007513)1.82737436
146Limb dystonia (HP:0002451)1.82638193
147Hyperthyroidism (HP:0000836)1.82602575
148Microvesicular hepatic steatosis (HP:0001414)1.82435754
149Absent speech (HP:0001344)1.81932744
150Genital tract atresia (HP:0001827)1.81865048

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.75257747
2MAP3K123.62934464
3MAP2K73.35526410
4TSSK63.30027061
5NTRK33.29494552
6MAP3K43.20618394
7MAP4K22.79358138
8AKT32.71387150
9PDK32.61956391
10PDK42.61956391
11NME12.47365157
12MARK12.43502288
13TRIM282.38265306
14TESK22.37160444
15DAPK12.31481777
16NTRK22.19058126
17PLK22.17561754
18MAP3K92.12417332
19EPHA41.91727090
20PRKD31.75194153
21CSNK1G31.73129985
22MINK11.68045176
23DAPK21.68005668
24MAP2K41.67694930
25GRK71.67368571
26CSNK1G21.62563595
27EPHA31.61924858
28PRKCG1.59775826
29CSNK1A1L1.58368732
30ERBB41.57317457
31PDK21.55113782
32MAP3K61.54752946
33TESK11.51371422
34CAMKK21.49606691
35NEK11.48084312
36MKNK21.45652421
37PRPF4B1.45028189
38STK38L1.40488219
39MYLK1.35762530
40CSNK1G11.31564790
41BRAF1.29960661
42CCNB11.27657412
43CDK81.26713928
44BMPR1B1.20701241
45PINK11.20172698
46BCKDK1.17745571
47EIF2AK11.15028271
48MAPK131.14692897
49SGK21.13523163
50CDK191.11527421
51GRK51.10954437
52SGK2231.10189420
53SGK4941.10189420
54EIF2AK31.06652880
55PRKCE1.06217717
56CDK51.05876597
57ARAF1.04405783
58UHMK10.97897077
59MAPK150.94963082
60YES10.90592222
61RPS6KA20.89836391
62STK160.89398530
63FES0.89346128
64CAMK2A0.88565574
65MUSK0.86350926
66CAMK2B0.83588718
67PLK30.83520630
68RPS6KA40.81872306
69RPS6KL10.80793380
70RPS6KC10.80793380
71SRPK10.79438627
72CAMKK10.78648604
73CDK180.78262353
74FRK0.76926348
75DAPK30.76778196
76TLK10.74116573
77CDK150.71567085
78MAP3K50.71167320
79SIK20.70893627
80MKNK10.70604310
81SGK30.68952905
82CDK140.66770119
83OXSR10.66315348
84STK380.66189818
85CDK11A0.64698286
86PAK60.62874095
87MAP3K110.62219492
88SCYL20.62043157
89RPS6KA60.61801539
90SIK30.61682167
91LIMK10.59963494
92PHKG20.59804295
93PHKG10.59804295
94CAMK10.59355421
95CAMK40.58915738
96CSNK1D0.52685178
97DYRK1A0.51551711
98CAMK2G0.51185822
99PLK10.50773145
100KSR10.48885184
101FER0.47966982
102MAP2K60.47920253
103CSNK1A10.47609176
104ROCK20.47567257
105BMPR20.46888688
106PRKCH0.45848311
107TNK20.45344462
108WNK30.44096334
109SGK10.44069439
110RPS6KB10.43210535
111INSRR0.42685020
112TAOK20.40755879
113ALK0.40303051
114STK240.38890512
115NEK60.38673985
116PKN10.38314414
117CAMK2D0.38275188
118BRSK10.38167745
119PIM20.37772709
120BCR0.37665099
121ATR0.35930307
122WNK40.35640621
123PRKACA0.35279762
124PLK40.35224240
125RPS6KA30.33417762
126DYRK20.33052443
127NTRK10.32822322
128RIPK40.32006647
129PRKCB0.31873839
130PAK30.31614599
131ERBB30.30718093
132PRKACB0.30283639
133AURKA0.29113532
134TAOK30.29057184
135PRKCZ0.28979784
136ADRBK10.28367421
137PRKCA0.27962456
138ADRBK20.27440800
139PRKAA10.25422020
140RPS6KA50.23992231
141TAOK10.22656330

Predicted pathways (KEGG)

RankGene SetZ-score
1Collecting duct acid secretion_Homo sapiens_hsa049664.04966150
2Synaptic vesicle cycle_Homo sapiens_hsa047213.98462048
3Nicotine addiction_Homo sapiens_hsa050333.76075077
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.63651027
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.43159101
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.24961138
7Oxidative phosphorylation_Homo sapiens_hsa001903.19457174
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.81194160
9GABAergic synapse_Homo sapiens_hsa047272.79941610
10Vibrio cholerae infection_Homo sapiens_hsa051102.68576233
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.41022863
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.32915609
13Parkinsons disease_Homo sapiens_hsa050122.27567662
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.26608050
15Morphine addiction_Homo sapiens_hsa050322.17732189
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06757524
17Pyruvate metabolism_Homo sapiens_hsa006202.05452560
18Circadian entrainment_Homo sapiens_hsa047132.02398014
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.94845608
20Sulfur relay system_Homo sapiens_hsa041221.90621071
21Olfactory transduction_Homo sapiens_hsa047401.88999117
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.88346965
23Long-term potentiation_Homo sapiens_hsa047201.79724149
24Alzheimers disease_Homo sapiens_hsa050101.73904893
25Glutamatergic synapse_Homo sapiens_hsa047241.73827982
26Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.64929019
27Vitamin B6 metabolism_Homo sapiens_hsa007501.64333727
28Huntingtons disease_Homo sapiens_hsa050161.61981145
29Type I diabetes mellitus_Homo sapiens_hsa049401.58772698
30Butanoate metabolism_Homo sapiens_hsa006501.53546951
31Taste transduction_Homo sapiens_hsa047421.52772933
32Long-term depression_Homo sapiens_hsa047301.51855701
33Protein export_Homo sapiens_hsa030601.51185612
34Dopaminergic synapse_Homo sapiens_hsa047281.50925683
35Amphetamine addiction_Homo sapiens_hsa050311.38305438
36Salivary secretion_Homo sapiens_hsa049701.38131660
37Rheumatoid arthritis_Homo sapiens_hsa053231.26985489
38Insulin secretion_Homo sapiens_hsa049111.19823764
39Serotonergic synapse_Homo sapiens_hsa047261.16963755
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.15973867
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12128037
42Calcium signaling pathway_Homo sapiens_hsa040201.08873424
43Phagosome_Homo sapiens_hsa041451.07425067
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05571757
45Cholinergic synapse_Homo sapiens_hsa047251.04771211
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02815907
47Cardiac muscle contraction_Homo sapiens_hsa042601.02373682
48Arginine biosynthesis_Homo sapiens_hsa002200.96011225
49Gastric acid secretion_Homo sapiens_hsa049710.95729673
50Carbon metabolism_Homo sapiens_hsa012000.92184557
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91919161
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.89989655
53Gap junction_Homo sapiens_hsa045400.89127267
54Fanconi anemia pathway_Homo sapiens_hsa034600.89083789
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87647005
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85822066
57Circadian rhythm_Homo sapiens_hsa047100.85007348
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84811103
59Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83163571
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81097928
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79800426
62Fatty acid elongation_Homo sapiens_hsa000620.79470024
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79187910
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76967059
65Sulfur metabolism_Homo sapiens_hsa009200.76951468
66Oxytocin signaling pathway_Homo sapiens_hsa049210.74481130
67Renin secretion_Homo sapiens_hsa049240.72623844
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72130531
69Biosynthesis of amino acids_Homo sapiens_hsa012300.70137393
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69507470
71Base excision repair_Homo sapiens_hsa034100.67866244
72Proteasome_Homo sapiens_hsa030500.67334223
73Cocaine addiction_Homo sapiens_hsa050300.63655825
74ErbB signaling pathway_Homo sapiens_hsa040120.62936817
75Steroid biosynthesis_Homo sapiens_hsa001000.62311419
76cAMP signaling pathway_Homo sapiens_hsa040240.58516772
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57805812
78Axon guidance_Homo sapiens_hsa043600.55939316
79Melanogenesis_Homo sapiens_hsa049160.53899347
80Spliceosome_Homo sapiens_hsa030400.53807087
81Ether lipid metabolism_Homo sapiens_hsa005650.53309013
82Folate biosynthesis_Homo sapiens_hsa007900.48582109
83Oocyte meiosis_Homo sapiens_hsa041140.47078039
84Estrogen signaling pathway_Homo sapiens_hsa049150.46802909
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45705473
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44839210
87Glioma_Homo sapiens_hsa052140.44571990
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44288381
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44149499
90Homologous recombination_Homo sapiens_hsa034400.42501523
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.41491502
92beta-Alanine metabolism_Homo sapiens_hsa004100.41202626
93Arginine and proline metabolism_Homo sapiens_hsa003300.40608270
94Type II diabetes mellitus_Homo sapiens_hsa049300.39916364
95Selenocompound metabolism_Homo sapiens_hsa004500.39695180
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39574406
97GnRH signaling pathway_Homo sapiens_hsa049120.39337944
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36916714
99Glucagon signaling pathway_Homo sapiens_hsa049220.36559158
100Vitamin digestion and absorption_Homo sapiens_hsa049770.36533013
101RNA transport_Homo sapiens_hsa030130.36126326
102Alcoholism_Homo sapiens_hsa050340.35655694
103Thyroid hormone synthesis_Homo sapiens_hsa049180.35478988
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35244588
105RNA polymerase_Homo sapiens_hsa030200.35004489
106Propanoate metabolism_Homo sapiens_hsa006400.33466482
107RNA degradation_Homo sapiens_hsa030180.32985977
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32688949
109Phenylalanine metabolism_Homo sapiens_hsa003600.31329416
110mRNA surveillance pathway_Homo sapiens_hsa030150.31322724
111AMPK signaling pathway_Homo sapiens_hsa041520.31182396
112Dilated cardiomyopathy_Homo sapiens_hsa054140.31041787
113Regulation of autophagy_Homo sapiens_hsa041400.29125217
114Melanoma_Homo sapiens_hsa052180.28550744
115Basal transcription factors_Homo sapiens_hsa030220.27793682
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25602379
117Fructose and mannose metabolism_Homo sapiens_hsa000510.25107033
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24050181
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23440773
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23343263
121Pyrimidine metabolism_Homo sapiens_hsa002400.22325246
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.20247811
123Ras signaling pathway_Homo sapiens_hsa040140.18712102
124MAPK signaling pathway_Homo sapiens_hsa040100.18379229
125Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.18350257
126Metabolic pathways_Homo sapiens_hsa011000.16975007
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.16638315
128Phototransduction_Homo sapiens_hsa047440.15480669
129Purine metabolism_Homo sapiens_hsa002300.13404951
130Non-small cell lung cancer_Homo sapiens_hsa052230.13401616
131Tyrosine metabolism_Homo sapiens_hsa003500.11699030
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.11513129
133Endometrial cancer_Homo sapiens_hsa052130.08882155

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