COTL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.28587869
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.28587869
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.27397469
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.27397469
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.27397469
6modulation by symbiont of host immune response (GO:0052553)5.27397469
7positive regulation by symbiont of host defense response (GO:0052509)5.27397469
8modulation by symbiont of host defense response (GO:0052031)5.27397469
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.10602813
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.10602813
11leukocyte aggregation (GO:0070486)5.08470097
12positive regulation of gamma-delta T cell activation (GO:0046645)4.95557647
13regulation of B cell receptor signaling pathway (GO:0050855)4.92775130
14detection of other organism (GO:0098543)4.92195188
15antigen processing and presentation of endogenous antigen (GO:0019883)4.81234132
16detection of bacterium (GO:0016045)4.78218193
17cellular extravasation (GO:0045123)4.31332755
18Arp2/3 complex-mediated actin nucleation (GO:0034314)4.27453450
19respiratory burst (GO:0045730)4.18303590
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.14297355
21neutrophil activation involved in immune response (GO:0002283)4.10280005
22regulation of interferon-beta biosynthetic process (GO:0045357)4.08092233
23detection of external biotic stimulus (GO:0098581)4.06365276
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.02837050
25response to peptidoglycan (GO:0032494)3.90215731
26immunoglobulin mediated immune response (GO:0016064)3.87010357
27regulation of gamma-delta T cell differentiation (GO:0045586)3.82829814
28positive thymic T cell selection (GO:0045059)3.80239513
29negative regulation of lymphocyte mediated immunity (GO:0002707)3.77978083
30detection of molecule of bacterial origin (GO:0032490)3.73289736
31macrophage activation involved in immune response (GO:0002281)3.69479439
32regulation of gamma-delta T cell activation (GO:0046643)3.68313068
33tolerance induction (GO:0002507)3.64144373
34leukocyte cell-cell adhesion (GO:0007159)3.63460543
35detection of biotic stimulus (GO:0009595)3.62141245
36negative regulation of interleukin-12 production (GO:0032695)3.62096972
37regulation of T cell tolerance induction (GO:0002664)3.53164670
38response to host immune response (GO:0052572)3.52902703
39response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.52902703
40regulation of myeloid leukocyte mediated immunity (GO:0002886)3.50903634
41positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.49731089
42T cell migration (GO:0072678)3.49543787
43negative regulation of leukocyte mediated immunity (GO:0002704)3.49273075
44negative regulation of phagocytosis (GO:0050765)3.48647914
45regulation of mast cell activation involved in immune response (GO:0033006)3.48172569
46positive regulation of interferon-alpha production (GO:0032727)3.46228712
47negative thymic T cell selection (GO:0045060)3.43365891
48negative regulation of erythrocyte differentiation (GO:0045647)3.41845658
49regulation of B cell differentiation (GO:0045577)3.39396326
50response to host (GO:0075136)3.39378650
51response to host defenses (GO:0052200)3.39378650
52response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.39378650
53negative regulation of T cell mediated immunity (GO:0002710)3.37538354
54B cell receptor signaling pathway (GO:0050853)3.37014248
55negative T cell selection (GO:0043383)3.33214514
56response to muramyl dipeptide (GO:0032495)3.32818804
57regulation of interferon-alpha production (GO:0032647)3.31469730
58neutrophil activation (GO:0042119)3.31356497
59regulation of tolerance induction (GO:0002643)3.28707348
60granulocyte activation (GO:0036230)3.28523877
61positive regulation of antigen processing and presentation (GO:0002579)3.28346024
62microglial cell activation (GO:0001774)3.28242910
63regulation of interleukin-12 biosynthetic process (GO:0045075)3.27426454
64regulation of dendritic cell antigen processing and presentation (GO:0002604)3.24851028
65positive regulation of B cell differentiation (GO:0045579)3.20939830
66macrophage activation (GO:0042116)3.19150521
67thymic T cell selection (GO:0045061)3.15798956
68actin nucleation (GO:0045010)3.14937663
69positive regulation of mast cell activation (GO:0033005)3.11797664
70myeloid cell activation involved in immune response (GO:0002275)3.09150710
71positive regulation of mast cell degranulation (GO:0043306)3.08453259
72positive regulation of mast cell activation involved in immune response (GO:0033008)3.08453259
73neutrophil mediated immunity (GO:0002446)3.04810774
74JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.03788510
75activated T cell proliferation (GO:0050798)3.03481575
76regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.02517208
77positive regulation of lamellipodium assembly (GO:0010592)3.00854663
78regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.00516343
79leukocyte degranulation (GO:0043299)2.98578756
80regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.97327208
81regulation of natural killer cell mediated immunity (GO:0002715)2.97327208
82negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.97267628
83cellular response to interleukin-15 (GO:0071350)2.97247832
84B cell mediated immunity (GO:0019724)2.96506725
85positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.96435187
86regulation of regulated secretory pathway (GO:1903305)2.92739441
87regulation of T-helper 2 cell differentiation (GO:0045628)2.92069347
88myeloid dendritic cell activation (GO:0001773)2.90499021
89mannose metabolic process (GO:0006013)2.89892750
90myeloid dendritic cell differentiation (GO:0043011)2.88407487
91positive T cell selection (GO:0043368)2.87920264
92interferon-gamma-mediated signaling pathway (GO:0060333)2.85829627
93neutrophil chemotaxis (GO:0030593)2.85327356
94negative regulation of granulocyte differentiation (GO:0030853)2.84977962
95response to laminar fluid shear stress (GO:0034616)2.83500358
96positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.83429761
97barbed-end actin filament capping (GO:0051016)2.83336046
98regulation of alpha-beta T cell proliferation (GO:0046640)2.83325655
99regulation of T cell mediated cytotoxicity (GO:0001914)2.82036309
100negative regulation of interleukin-6 production (GO:0032715)2.81811745
101T cell selection (GO:0045058)2.81609407
102pinocytosis (GO:0006907)2.81122686
103positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.80907089
104neutrophil migration (GO:1990266)2.79622030
105regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.77250314
106positive regulation of isotype switching (GO:0045830)2.76121205
107regulation of antigen processing and presentation (GO:0002577)2.75266656
108positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.74812991
109negative regulation of type 2 immune response (GO:0002829)2.74621757
110production of molecular mediator involved in inflammatory response (GO:0002532)2.74616130
111regulation of type I interferon-mediated signaling pathway (GO:0060338)2.74436321
112positive regulation of T cell mediated cytotoxicity (GO:0001916)2.74154437
113regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.73935039
114germinal center formation (GO:0002467)2.73104586
115NIK/NF-kappaB signaling (GO:0038061)2.71919943
116response to interleukin-15 (GO:0070672)2.71412926
117apoptotic cell clearance (GO:0043277)2.71253404
118interferon-gamma production (GO:0032609)2.69554696
119positive regulation of lamellipodium organization (GO:1902745)2.69543424
120regulation of mast cell degranulation (GO:0043304)2.69319227
121response to protozoan (GO:0001562)2.67419993
122lipopolysaccharide-mediated signaling pathway (GO:0031663)2.66786351
123cellular response to zinc ion (GO:0071294)2.66673090
124defense response to protozoan (GO:0042832)2.66513495
125leukocyte migration involved in inflammatory response (GO:0002523)2.65775670
126antigen processing and presentation via MHC class Ib (GO:0002475)2.64100118
127response to type I interferon (GO:0034340)2.63260133
128sequestering of actin monomers (GO:0042989)2.62718349
129regulation of leukocyte degranulation (GO:0043300)2.60786850
130cellular response to type I interferon (GO:0071357)2.60452552
131type I interferon signaling pathway (GO:0060337)2.60452552
132regulation of mast cell activation (GO:0033003)2.59290718
133T cell costimulation (GO:0031295)2.58187897
134T cell proliferation (GO:0042098)2.57107469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_21731497_ChIP-ChIP_J774_Mouse4.01309868
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.84956823
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.70666604
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.65565443
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.45992611
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.45065203
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.33805538
8* MYC_22102868_ChIP-Seq_BL_Human3.23058649
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.10827174
10IRF8_27001747_Chip-Seq_BMDM_Mouse3.05935111
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.04144819
12VDR_21846776_ChIP-Seq_THP-1_Human3.01033111
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.87885452
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.78324328
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.64478478
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.62465689
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.59267969
18E2F7_22180533_ChIP-Seq_HELA_Human2.52916292
19MAF_26560356_Chip-Seq_TH1_Human2.49010524
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.40920432
21BRD4_27068464_Chip-Seq_AML-cells_Mouse2.39730552
22VDR_24763502_ChIP-Seq_THP-1_Human2.31318714
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.27843033
24* MYB_26560356_Chip-Seq_TH2_Human2.25217911
25TCF7_22412390_ChIP-Seq_EML_Mouse2.23737936
26* SPI1_23547873_ChIP-Seq_NB4_Human2.20909780
27UTX_26944678_Chip-Seq_JUKART_Human2.18843100
28* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.14586369
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.11489341
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.10067283
31RUNX1_22412390_ChIP-Seq_EML_Mouse2.08803941
32RUNX_20019798_ChIP-Seq_JUKART_Human2.05190265
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.01174543
34SCL_19346495_ChIP-Seq_HPC-7_Human1.97493651
35* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.96525535
36SPI1_23127762_ChIP-Seq_K562_Human1.95598295
37MYB_26560356_Chip-Seq_TH1_Human1.91998451
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.91573630
39KDM2B_26808549_Chip-Seq_DND41_Human1.90392663
40* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.90155658
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.87727775
42* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86693404
43* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.80259676
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.79771761
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.79252746
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.68530212
47MAF_26560356_Chip-Seq_TH2_Human1.64258701
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.64217060
49LXR_22292898_ChIP-Seq_THP-1_Human1.59591481
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58861541
51EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.57902701
52* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.54579258
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.54103755
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.50775288
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50328408
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.49230490
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.46722299
58PU_27001747_Chip-Seq_BMDM_Mouse1.43902740
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42576587
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42525632
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40176804
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36628443
63GATA3_27048872_Chip-Seq_THYMUS_Human1.36415476
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34987183
65CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33676301
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32434945
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24883141
68GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21189959
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20784349
70* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15183508
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.15125048
72* KDM2B_26808549_Chip-Seq_JURKAT_Human1.14340880
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13149931
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12116239
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10808111
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10109799
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09862992
78NCOR1_26117541_ChIP-Seq_K562_Human1.09550605
79CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04902119
80* RACK7_27058665_Chip-Seq_MCF-7_Human1.03070193
81CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02453532
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01887743
83* GATA1_19941827_ChIP-Seq_MEL_Mouse1.01655168
84VDR_24787735_ChIP-Seq_THP-1_Human1.01485884
85SA1_27219007_Chip-Seq_ERYTHROID_Human0.98631020
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98069435
87TFEB_21752829_ChIP-Seq_HELA_Human0.96307674
88* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94725313
89RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94250559
90* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93869029
91SPI1_20517297_ChIP-Seq_HL60_Human0.93609654
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92548536
93CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92442336
94RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91950353
95BCL6_27268052_Chip-Seq_Bcells_Human0.91647170
96PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89234221
97BCOR_27268052_Chip-Seq_Bcells_Human0.88206911
98GATA2_21666600_ChIP-Seq_HMVEC_Human0.87193963
99* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87121294
100P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86386649
101KDM2B_26808549_Chip-Seq_K562_Human0.86156874
102PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85932257
103* GATA3_26560356_Chip-Seq_TH2_Human0.84691688
104TP63_17297297_ChIP-ChIP_HaCaT_Human0.84672020
105GATA1_19941826_ChIP-Seq_K562_Human0.83048951
106CIITA_25753668_ChIP-Seq_RAJI_Human0.82955106
107* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82713971
108* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81380202
109ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.80499768
110SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.80351067
111ELF1_20517297_ChIP-Seq_JURKAT_Human0.78780917

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.29512537
2MP0003436_decreased_susceptibility_to3.71327130
3MP0001835_abnormal_antigen_presentation3.62254233
4MP0000685_abnormal_immune_system3.03319870
5MP0005387_immune_system_phenotype3.00037461
6MP0001790_abnormal_immune_system3.00037461
7MP0005000_abnormal_immune_tolerance2.90350547
8MP0002419_abnormal_innate_immunity2.80072254
9MP0003300_gastrointestinal_ulcer2.79158400
10MP0001800_abnormal_humoral_immune2.78270362
11MP0005058_abnormal_lysosome_morphology2.75525409
12MP0002452_abnormal_antigen_presenting2.69346857
13MP0005025_abnormal_response_to2.61918057
14MP0009785_altered_susceptibility_to2.59510715
15MP0006082_CNS_inflammation2.51157485
16MP0002420_abnormal_adaptive_immunity2.47703445
17MP0001819_abnormal_immune_cell2.46207879
18MP0002723_abnormal_immune_serum2.43757967
19MP0005671_abnormal_response_to2.41461551
20MP0002148_abnormal_hypersensitivity_rea2.38678687
21MP0004510_myositis2.34541591
22MP0002405_respiratory_system_inflammati2.28778420
23MP0005464_abnormal_platelet_physiology2.22363947
24MP0009333_abnormal_splenocyte_physiolog2.13672689
25MP0009278_abnormal_bone_marrow2.08101725
26MP0002398_abnormal_bone_marrow2.06999518
27MP0003172_abnormal_lysosome_physiology2.06357127
28MP0003763_abnormal_thymus_physiology2.04674467
29MP0008260_abnormal_autophagy2.00907817
30MP0000716_abnormal_immune_system1.96901882
31MP0004947_skin_inflammation1.95733644
32MP0001533_abnormal_skeleton_physiology1.94619197
33MP0001845_abnormal_inflammatory_respons1.83230683
34MP0000689_abnormal_spleen_morphology1.80801825
35MP0003724_increased_susceptibility_to1.79377911
36MP0010155_abnormal_intestine_physiology1.76617175
37MP0001873_stomach_inflammation1.75433342
38MP0009840_abnormal_foam_cell1.71890243
39MP0002722_abnormal_immune_system1.71165597
40MP0002429_abnormal_blood_cell1.65465718
41MP0003191_abnormal_cellular_cholesterol1.64117620
42MP0000465_gastrointestinal_hemorrhage1.61835086
43MP0001853_heart_inflammation1.61325131
44MP0005076_abnormal_cell_differentiation1.60610656
45MP0005451_abnormal_body_composition1.59108846
46MP0002396_abnormal_hematopoietic_system1.58112990
47MP0003448_altered_tumor_morphology1.55983277
48MP0002166_altered_tumor_susceptibility1.52273736
49MP0000858_altered_metastatic_potential1.50362387
50MP0002933_joint_inflammation1.44941832
51MP0004808_abnormal_hematopoietic_stem1.44508544
52MP0003566_abnormal_cell_adhesion1.43386735
53MP0002132_abnormal_respiratory_system1.40724203
54MP0003183_abnormal_peptide_metabolism1.40149840
55MP0005310_abnormal_salivary_gland1.39730423
56MP0001851_eye_inflammation1.35525062
57MP0000703_abnormal_thymus_morphology1.34691989
58MP0000490_abnormal_crypts_of1.34531958
59MP0001545_abnormal_hematopoietic_system1.34114095
60MP0005397_hematopoietic_system_phenotyp1.34114095
61MP0008469_abnormal_protein_level1.31151228
62MP0003866_abnormal_defecation1.26882171
63MP0010352_gastrointestinal_tract_polyps1.26601412
64MP0003075_altered_response_to1.26585900
65MP0002006_tumorigenesis1.26214682
66MP0000343_altered_response_to1.26182933
67MP0003705_abnormal_hypodermis_morpholog1.24849924
68MP0004883_abnormal_blood_vessel1.24644099
69MP0010307_abnormal_tumor_latency1.16037437
70MP0002998_abnormal_bone_remodeling1.13638381
71MP0000604_amyloidosis1.11856406
72MP0003806_abnormal_nucleotide_metabolis1.06615590
73MP0005164_abnormal_response_to1.05000456
74MP0005166_decreased_susceptibility_to1.04091386
75MP0005174_abnormal_tail_pigmentation1.00322045
76MP0005023_abnormal_wound_healing0.97247291
77MP0004858_abnormal_nervous_system0.97050009
78MP0005390_skeleton_phenotype0.90849598
79MP0001663_abnormal_digestive_system0.89061641
80MP0000569_abnormal_digit_pigmentation0.88121529
81MP0009764_decreased_sensitivity_to0.86087263
82MP0008004_abnormal_stomach_pH0.86015578
83MP0005167_abnormal_blood-brain_barrier0.85197721
84MP0004381_abnormal_hair_follicle0.82530992
85MP0008961_abnormal_basal_metabolism0.80153513
86MP0003091_abnormal_cell_migration0.79152874
87MP0002277_abnormal_respiratory_mucosa0.77631682
88MP0002019_abnormal_tumor_incidence0.77223578
89MP0002138_abnormal_hepatobiliary_system0.76421962
90MP0003453_abnormal_keratinocyte_physiol0.75123791
91MP0000249_abnormal_blood_vessel0.74841415
92MP0003795_abnormal_bone_structure0.74226413
93MP0002136_abnormal_kidney_physiology0.72087819
94MP0001849_ear_inflammation0.70275674
95MP0003828_pulmonary_edema0.70254252
96MP0009763_increased_sensitivity_to0.67758077
97MP0003690_abnormal_glial_cell0.65281764
98MP0001915_intracranial_hemorrhage0.64641187
99MP0008874_decreased_physiological_sensi0.63582818
100MP0000371_diluted_coat_color0.62695426
101MP0001542_abnormal_bone_strength0.62429231
102MP0001958_emphysema0.61945662
103MP0001348_abnormal_lacrimal_gland0.60712370
104MP0003279_aneurysm0.57013440
105MP0000477_abnormal_intestine_morphology0.56755524
106MP0000767_abnormal_smooth_muscle0.56654790
107MP0009765_abnormal_xenobiotic_induced0.56597705
108MP0000015_abnormal_ear_pigmentation0.55808629
109MP0002877_abnormal_melanocyte_morpholog0.54685667
110MP0003221_abnormal_cardiomyocyte_apopto0.54024756
111MP0002135_abnormal_kidney_morphology0.52526791
112MP0004185_abnormal_adipocyte_glucose0.50989028
113MP0008873_increased_physiological_sensi0.50816200
114MP0000733_abnormal_muscle_development0.50293550
115MP0003045_fibrosis0.49582114
116MP0000609_abnormal_liver_physiology0.48742346

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.30488155
2Recurrent abscess formation (HP:0002722)6.06263697
3Recurrent bacterial skin infections (HP:0005406)5.15018921
4Recurrent gram-negative bacterial infections (HP:0005420)4.83800219
5Systemic lupus erythematosus (HP:0002725)4.31693467
6Abnormality of macrophages (HP:0004311)4.10590787
7Vacuolated lymphocytes (HP:0001922)4.09498745
8Recurrent fungal infections (HP:0002841)3.85795196
9Mediastinal lymphadenopathy (HP:0100721)3.83813737
10Elevated erythrocyte sedimentation rate (HP:0003565)3.82111851
11Increased cerebral lipofuscin (HP:0011813)3.77541374
12Dysostosis multiplex (HP:0000943)3.72740979
13Obstructive lung disease (HP:0006536)3.70701398
14Chronic obstructive pulmonary disease (HP:0006510)3.70701398
15Myositis (HP:0100614)3.64393245
16IgM deficiency (HP:0002850)3.50043065
17Pustule (HP:0200039)3.45219899
18Cellulitis (HP:0100658)3.44150363
19Gingivitis (HP:0000230)3.36864183
20Recurrent skin infections (HP:0001581)3.33522953
21Encephalitis (HP:0002383)3.29489853
22Recurrent viral infections (HP:0004429)3.26402053
23Nasal polyposis (HP:0100582)3.23271496
24Spontaneous hematomas (HP:0007420)3.12948687
25Stomatitis (HP:0010280)3.12531079
26Increased neuronal autofluorescent lipopigment (HP:0002074)3.10294397
27Chronic otitis media (HP:0000389)3.10128413
28Autoimmune thrombocytopenia (HP:0001973)3.09403818
29Mucopolysacchariduria (HP:0008155)3.08566747
30Urinary glycosaminoglycan excretion (HP:0003541)3.08566747
31Abnormality of the nasal mucosa (HP:0000433)2.99715940
32Keratoconjunctivitis sicca (HP:0001097)2.94495862
33Meningitis (HP:0001287)2.92510601
34Abnormality of polysaccharide metabolism (HP:0011012)2.86844248
35Abnormality of glycosaminoglycan metabolism (HP:0004371)2.86844248
36Abnormality of mucopolysaccharide metabolism (HP:0011020)2.86844248
37Inflammation of the large intestine (HP:0002037)2.86765278
38Gastrointestinal inflammation (HP:0004386)2.85833526
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.84511636
40Interstitial pulmonary disease (HP:0006530)2.82854975
41Orchitis (HP:0100796)2.80840276
42Disinhibition (HP:0000734)2.80422810
43Increased density of long bones (HP:0006392)2.79930469
44Amyloidosis (HP:0011034)2.78763607
45Glomerulonephritis (HP:0000099)2.77892387
46Abnormality of glycolipid metabolism (HP:0010969)2.76421895
47Abnormality of liposaccharide metabolism (HP:0010968)2.76421895
48Abnormality of glycosphingolipid metabolism (HP:0004343)2.76421895
49Vasculitis (HP:0002633)2.72373652
50Peritonitis (HP:0002586)2.70957866
51Recurrent cutaneous fungal infections (HP:0011370)2.66070519
52Chronic mucocutaneous candidiasis (HP:0002728)2.66070519
53Episodic fever (HP:0001954)2.65596214
54Keratoconjunctivitis (HP:0001096)2.64676626
55Increased IgM level (HP:0003496)2.62351471
56Recurrent bronchitis (HP:0002837)2.58461272
57Urticaria (HP:0001025)2.58292339
58Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.58076279
59Loss of speech (HP:0002371)2.52424201
60Periodontitis (HP:0000704)2.51851418
61Cerebral aneurysm (HP:0004944)2.51269015
62Colitis (HP:0002583)2.51128220
63Purpura (HP:0000979)2.48192768
64Petechiae (HP:0000967)2.45675627
65T lymphocytopenia (HP:0005403)2.45585140
66Abnormality of T cell number (HP:0011839)2.41898720
67Abnormality of T cells (HP:0002843)2.41015153
68Verrucae (HP:0200043)2.33301425
69Papilloma (HP:0012740)2.33301425
70Leukocytosis (HP:0001974)2.31001711
71Hepatosplenomegaly (HP:0001433)2.30687670
72Hypergammaglobulinemia (HP:0010702)2.26357459
73Osteomyelitis (HP:0002754)2.25106955
74Hematochezia (HP:0002573)2.24803462
75Chest pain (HP:0100749)2.24310615
76Increased IgE level (HP:0003212)2.24275136
77Optic neuritis (HP:0100653)2.23518206
78Retrobulbar optic neuritis (HP:0100654)2.23518206
79Anorexia (HP:0002039)2.23027674
80Agammaglobulinemia (HP:0004432)2.22820927
81Granulocytopenia (HP:0001913)2.22067588
82Lymphopenia (HP:0001888)2.21197940
83Abnormality of cells of the lymphoid lineage (HP:0012140)2.19862799
84Abnormality of T cell physiology (HP:0011840)2.19784628
85Glomerulopathy (HP:0100820)2.18771375
86Arterial thrombosis (HP:0004420)2.18315679
87Abnormality of the peritoneum (HP:0002585)2.15315508
88Pulmonary embolism (HP:0002204)2.14799642
89Pulmonary infiltrates (HP:0002113)2.13577959
90Hypochromic anemia (HP:0001931)2.13166853
91Prolonged bleeding time (HP:0003010)2.12956495
92Thrombocytosis (HP:0001894)2.12912107
93Spondylolisthesis (HP:0003302)2.12451721
94Hypochromic microcytic anemia (HP:0004840)2.06994032
95Increased serum ferritin (HP:0003281)2.06802572
96Panhypogammaglobulinemia (HP:0003139)2.05313926
97Skin ulcer (HP:0200042)2.03086632
98Thoracic kyphosis (HP:0002942)2.01663252
99Hypertensive crisis (HP:0100735)2.00016661
100Abnormality of the pleura (HP:0002103)1.99670231
101Hemoptysis (HP:0002105)1.99599387
102Emphysema (HP:0002097)1.98051482
103Diminished motivation (HP:0000745)1.97702613
104Axonal loss (HP:0003447)1.97313325
105Premature loss of primary teeth (HP:0006323)1.96279323
106Epistaxis (HP:0000421)1.95884697
107Recurrent lower respiratory tract infections (HP:0002783)1.94242544
108Nephritis (HP:0000123)1.93339613
109Eosinophilia (HP:0001880)1.93264966
110Abnormal platelet function (HP:0011869)1.92786288
111Impaired platelet aggregation (HP:0003540)1.92786288
112Recurrent pneumonia (HP:0006532)1.92682263
113Gastrointestinal stroma tumor (HP:0100723)1.92624031
114Restrictive lung disease (HP:0002091)1.92559032
115Agnosia (HP:0010524)1.92335928
116Slow saccadic eye movements (HP:0000514)1.90382220
117Abnormality of the pericardium (HP:0001697)1.88903640
118Apathy (HP:0000741)1.88700856
119Viral hepatitis (HP:0006562)1.88493007
120Gastrointestinal infarctions (HP:0005244)1.88334579
121Basal ganglia calcification (HP:0002135)1.88306391
122Myocardial infarction (HP:0001658)1.88247814
123Abnormality of complement system (HP:0005339)1.87787548
124Sepsis (HP:0100806)1.86612881
125Abnormal platelet volume (HP:0011876)1.85772857
126Gingival bleeding (HP:0000225)1.85394530
127Amaurosis fugax (HP:0100576)1.84658587
128Frequent falls (HP:0002359)1.83534706
129Gangrene (HP:0100758)1.82441164
130Arthralgia (HP:0002829)1.82087310
131Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.81667169
132Skin rash (HP:0000988)1.81340493
133Polygenic inheritance (HP:0010982)1.80598798
134Upper motor neuron abnormality (HP:0002127)1.77715185

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.92716739
2BLK3.27116476
3TRIB33.06626337
4PRPF4B2.84568422
5ERN12.82066615
6PKN22.58003897
7STK102.46035394
8ZAP702.34207234
9TYK22.27187996
10GRK62.24346601
11TBK12.19497536
12EEF2K2.18010133
13IRAK42.15283981
14TXK2.14358038
15MAP3K102.11024644
16JAK31.97070151
17LRRK21.79461336
18SIK31.76990348
19TESK21.73694026
20BTK1.72846040
21CSK1.69762910
22TGFBR21.69563315
23RIPK41.67867558
24MAP3K141.66566373
25EPHB11.61489708
26HCK1.54509888
27SMG11.53809596
28KIT1.51343251
29CSF1R1.48273496
30FES1.47255394
31ITK1.47035826
32SYK1.44365546
33IKBKE1.42402022
34TAOK21.40570653
35PTK61.35902641
36JAK11.30734711
37MAP2K31.23243255
38LCK1.22035183
39RPS6KA41.21796078
40RIPK11.21529532
41CLK11.19942814
42SIK21.19243417
43TESK11.17041399
44TTN1.14018674
45IKBKB1.13523633
46MAP3K111.11993303
47FGFR41.10812424
48NME21.04918784
49BMX1.03528249
50SCYL21.02963075
51PAK41.01986055
52MARK31.01328050
53FGR1.00513600
54TEC1.00477953
55PIM10.99410649
56KDR0.97717089
57YES10.95981060
58PRKD20.92608945
59CDK120.92276580
60CAMK1D0.92219461
61ALK0.91824569
62JAK20.91801308
63IRAK30.91399754
64LYN0.90275169
65BMPR20.89816311
66MAP3K130.89533961
67CDK190.88310524
68FGFR30.81674816
69PRKCH0.81033424
70MOS0.80987629
71CDC42BPA0.79203342
72MARK20.77426094
73IRAK20.76561599
74PDPK10.76140089
75CHUK0.74701533
76PIM20.68297343
77TAOK30.66920102
78MST1R0.66886732
79MAP3K80.66597495
80TAOK10.62685836
81CAMK1G0.62161964
82NEK20.59831883
83ARAF0.59242311
84RPS6KA60.56768345
85IRAK10.56672257
86MAP3K60.54901911
87FLT30.53132294
88EGFR0.51218805
89MATK0.50964927
90RPS6KL10.49439107
91RPS6KC10.49439107
92KSR10.49289235
93PTK2B0.49147984
94GRK70.48577054
95MAP3K30.48245003
96CDK60.47771949
97MST40.47706544
98NEK90.47096301
99CDK40.46925012
100MAPK70.45955332
101TRPM70.45503425
102PRKCQ0.45449877
103MAP3K70.45292300
104MAP3K50.45242346
105RPS6KA20.44559846
106MAPKAPK20.43890129
107FYN0.43499536
108HIPK20.43413402
109MAPK120.42487940
110TNK20.41820526
111EPHA30.41764798
112CAMKK10.40813710
113DMPK0.40650873
114DYRK1B0.39700004
115ICK0.39639949
116SIK10.37939404
117RAF10.37894309
118PRKG20.37533575
119PDK10.37267291
120KSR20.36965234
121STK40.36741223
122PRKCD0.36270193
123ABL10.35342475
124ILK0.34930948
125MAP3K10.33951740
126RPS6KA10.32323996
127STK380.31441322
128PIK3CG0.31087426
129MAPK40.30858166
130CAMKK20.30675771

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.08739579
2Staphylococcus aureus infection_Homo sapiens_hsa051502.86934076
3Osteoclast differentiation_Homo sapiens_hsa043802.56688549
4B cell receptor signaling pathway_Homo sapiens_hsa046622.35970310
5Other glycan degradation_Homo sapiens_hsa005112.34463202
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.22799352
7Primary immunodeficiency_Homo sapiens_hsa053402.13657197
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.07724638
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.02855741
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.99620426
11Pertussis_Homo sapiens_hsa051331.93364917
12Antigen processing and presentation_Homo sapiens_hsa046121.90695188
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.89664584
14Lysosome_Homo sapiens_hsa041421.89652895
15Tuberculosis_Homo sapiens_hsa051521.84880543
16Measles_Homo sapiens_hsa051621.84117152
17T cell receptor signaling pathway_Homo sapiens_hsa046601.77559617
18Legionellosis_Homo sapiens_hsa051341.76437252
19Shigellosis_Homo sapiens_hsa051311.75416474
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.74032106
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.73319291
22Toxoplasmosis_Homo sapiens_hsa051451.67734849
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.67243984
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.66429590
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.65205286
26Hematopoietic cell lineage_Homo sapiens_hsa046401.58505309
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.56735374
28Chemokine signaling pathway_Homo sapiens_hsa040621.56228576
29Malaria_Homo sapiens_hsa051441.52563763
30Chronic myeloid leukemia_Homo sapiens_hsa052201.46513750
31Viral myocarditis_Homo sapiens_hsa054161.46036866
32Apoptosis_Homo sapiens_hsa042101.41150408
33Acute myeloid leukemia_Homo sapiens_hsa052211.40352397
34Salmonella infection_Homo sapiens_hsa051321.39988946
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36803115
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.30687767
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30082581
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.29916303
39TNF signaling pathway_Homo sapiens_hsa046681.29882291
40Pancreatic cancer_Homo sapiens_hsa052121.29126708
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.29105425
42Influenza A_Homo sapiens_hsa051641.28146505
43Hepatitis B_Homo sapiens_hsa051611.27906307
44Graft-versus-host disease_Homo sapiens_hsa053321.26394787
45Asthma_Homo sapiens_hsa053101.25243760
46Herpes simplex infection_Homo sapiens_hsa051681.21794706
47Allograft rejection_Homo sapiens_hsa053301.19978069
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19921721
49Phagosome_Homo sapiens_hsa041451.14737317
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14525453
51Neurotrophin signaling pathway_Homo sapiens_hsa047221.13747584
52Platelet activation_Homo sapiens_hsa046111.09910467
53VEGF signaling pathway_Homo sapiens_hsa043701.01549880
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93119402
55Colorectal cancer_Homo sapiens_hsa052100.92902096
56Rheumatoid arthritis_Homo sapiens_hsa053230.89226446
57Non-small cell lung cancer_Homo sapiens_hsa052230.88850504
58Hepatitis C_Homo sapiens_hsa051600.84477032
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81746119
60Amoebiasis_Homo sapiens_hsa051460.80407843
61Endocytosis_Homo sapiens_hsa041440.79346864
62HTLV-I infection_Homo sapiens_hsa051660.79155343
63Viral carcinogenesis_Homo sapiens_hsa052030.78954404
64Prolactin signaling pathway_Homo sapiens_hsa049170.77752079
65Small cell lung cancer_Homo sapiens_hsa052220.76582070
66Epstein-Barr virus infection_Homo sapiens_hsa051690.75481257
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73801829
68Notch signaling pathway_Homo sapiens_hsa043300.72042540
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68916084
70Proteoglycans in cancer_Homo sapiens_hsa052050.68858567
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67083189
72Renal cell carcinoma_Homo sapiens_hsa052110.62650479
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59301109
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.58849915
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57398382
76HIF-1 signaling pathway_Homo sapiens_hsa040660.57119557
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56948858
78Endometrial cancer_Homo sapiens_hsa052130.54843155
79GnRH signaling pathway_Homo sapiens_hsa049120.50489678
80mTOR signaling pathway_Homo sapiens_hsa041500.50477803
81Adherens junction_Homo sapiens_hsa045200.49711100
82Insulin resistance_Homo sapiens_hsa049310.49542053
83Prion diseases_Homo sapiens_hsa050200.49121063
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47699302
85Thyroid cancer_Homo sapiens_hsa052160.46931241
86Choline metabolism in cancer_Homo sapiens_hsa052310.44425293
87Caffeine metabolism_Homo sapiens_hsa002320.43488785
88Focal adhesion_Homo sapiens_hsa045100.43348111
89Type I diabetes mellitus_Homo sapiens_hsa049400.42504575
90MicroRNAs in cancer_Homo sapiens_hsa052060.41331757
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.41278351
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40968785
93Autoimmune thyroid disease_Homo sapiens_hsa053200.40852618
94ErbB signaling pathway_Homo sapiens_hsa040120.40803400
95Galactose metabolism_Homo sapiens_hsa000520.40041039
96Glioma_Homo sapiens_hsa052140.39851794
97FoxO signaling pathway_Homo sapiens_hsa040680.39480462
98Rap1 signaling pathway_Homo sapiens_hsa040150.39234338
99Complement and coagulation cascades_Homo sapiens_hsa046100.38878882
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37885890
101Prostate cancer_Homo sapiens_hsa052150.36413700
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36256066
103Pentose phosphate pathway_Homo sapiens_hsa000300.35165427
104Inositol phosphate metabolism_Homo sapiens_hsa005620.33882843
105MAPK signaling pathway_Homo sapiens_hsa040100.33471035
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.33121231
107Pathways in cancer_Homo sapiens_hsa052000.31949667
108African trypanosomiasis_Homo sapiens_hsa051430.31049329
109Bladder cancer_Homo sapiens_hsa052190.29550021
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.28696656

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