COX10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.69059265
2telomere maintenance via semi-conservative replication (GO:0032201)5.15960693
3DNA strand elongation involved in DNA replication (GO:0006271)4.66162635
4telomere maintenance via recombination (GO:0000722)4.58521547
5DNA replication initiation (GO:0006270)4.58406932
6DNA strand elongation (GO:0022616)4.42711078
7proteasome assembly (GO:0043248)4.31378143
8ribosomal small subunit assembly (GO:0000028)4.30343461
9tricarboxylic acid cycle (GO:0006099)4.27033762
10establishment of integrated proviral latency (GO:0075713)4.17793711
11DNA replication checkpoint (GO:0000076)4.17026044
12mitotic recombination (GO:0006312)3.93584788
13telomere maintenance via telomere lengthening (GO:0010833)3.89191268
14cullin deneddylation (GO:0010388)3.84353852
15pseudouridine synthesis (GO:0001522)3.79223353
16pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.73253130
17DNA double-strand break processing (GO:0000729)3.67360683
18maturation of SSU-rRNA (GO:0030490)3.66530604
19ribosome assembly (GO:0042255)3.65697517
20viral transcription (GO:0019083)3.65475972
21L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.61710761
22tRNA aminoacylation for protein translation (GO:0006418)3.59432185
23ubiquinone biosynthetic process (GO:0006744)3.58914075
24quinone biosynthetic process (GO:1901663)3.58914075
25translational termination (GO:0006415)3.57939109
26amino acid activation (GO:0043038)3.57525151
27tRNA aminoacylation (GO:0043039)3.57525151
28transcription elongation from RNA polymerase III promoter (GO:0006385)3.52170849
29termination of RNA polymerase III transcription (GO:0006386)3.52170849
30CENP-A containing nucleosome assembly (GO:0034080)3.40485792
31deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.40463627
32non-recombinational repair (GO:0000726)3.39679064
33double-strand break repair via nonhomologous end joining (GO:0006303)3.39679064
34mitochondrial respiratory chain complex I assembly (GO:0032981)3.37563741
35NADH dehydrogenase complex assembly (GO:0010257)3.37563741
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.37563741
37establishment of viral latency (GO:0019043)3.36676049
38branched-chain amino acid catabolic process (GO:0009083)3.34275899
39ribosomal large subunit biogenesis (GO:0042273)3.34106528
40exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.33804803
41nucleotide-excision repair, DNA gap filling (GO:0006297)3.32689108
42oxidative phosphorylation (GO:0006119)3.32535694
43rRNA modification (GO:0000154)3.32001577
44regulation of cellular amino acid metabolic process (GO:0006521)3.31856527
45* cytochrome complex assembly (GO:0017004)3.31670600
46regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.31391122
47iron-sulfur cluster assembly (GO:0016226)3.31294902
48metallo-sulfur cluster assembly (GO:0031163)3.31294902
49DNA ligation (GO:0006266)3.30058359
50establishment of protein localization to mitochondrial membrane (GO:0090151)3.29871161
51maturation of 5.8S rRNA (GO:0000460)3.29314714
52DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.28803850
53mitotic metaphase plate congression (GO:0007080)3.27739143
54chromatin remodeling at centromere (GO:0031055)3.26409060
55translational elongation (GO:0006414)3.25605355
56signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.24384114
57intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.24384114
58signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.24165745
59signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.24165745
60signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.24165745
61pyrimidine nucleotide catabolic process (GO:0006244)3.22865786
62regulation of cofactor metabolic process (GO:0051193)3.21976270
63regulation of coenzyme metabolic process (GO:0051196)3.21976270
64ribosomal small subunit biogenesis (GO:0042274)3.21965283
65transcription-coupled nucleotide-excision repair (GO:0006283)3.18915393
66nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.18442001
67GDP-mannose metabolic process (GO:0019673)3.18278079
68DNA catabolic process, exonucleolytic (GO:0000738)3.16865456
697-methylguanosine mRNA capping (GO:0006370)3.16389425
70IMP biosynthetic process (GO:0006188)3.15461598
71positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.15183056
72SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.14958352
73muscle filament sliding (GO:0030049)3.14483307
74actin-myosin filament sliding (GO:0033275)3.14483307
75RNA capping (GO:0036260)3.12864535
767-methylguanosine RNA capping (GO:0009452)3.12864535
77signal transduction involved in DNA integrity checkpoint (GO:0072401)3.12084409
78signal transduction involved in DNA damage checkpoint (GO:0072422)3.12084409
79translational initiation (GO:0006413)3.10175657
80IMP metabolic process (GO:0046040)3.09883670
81regulation of acyl-CoA biosynthetic process (GO:0050812)3.09636137
82signal transduction involved in cell cycle checkpoint (GO:0072395)3.07704061
83ribonucleoprotein complex biogenesis (GO:0022613)3.07034793
84protein complex biogenesis (GO:0070271)3.06518215
85spliceosomal snRNP assembly (GO:0000387)3.05589954
86histone exchange (GO:0043486)3.05458605
87cotranslational protein targeting to membrane (GO:0006613)3.04768745
88regulation of mitochondrial translation (GO:0070129)3.03642184
89negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.03288014
90positive regulation of ligase activity (GO:0051351)3.03256460
91protein targeting to mitochondrion (GO:0006626)3.02955010
92mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.02352453
93mitochondrial RNA metabolic process (GO:0000959)3.01885081
94anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.01760342
95protein targeting to ER (GO:0045047)3.01319329
96kinetochore assembly (GO:0051382)3.01237349
97ubiquinone metabolic process (GO:0006743)2.99817356
98chaperone-mediated protein transport (GO:0072321)2.99775068
99mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.98597008
100transcription from mitochondrial promoter (GO:0006390)2.98528203
101regulation of ubiquitin-protein transferase activity (GO:0051438)2.98089008
102regulation of double-strand break repair via homologous recombination (GO:0010569)2.94816964
103regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.94102685
104regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.93771029
105ribosome biogenesis (GO:0042254)2.93516248
106viral mRNA export from host cell nucleus (GO:0046784)2.93176872
107protein deneddylation (GO:0000338)2.92583242
108negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.92397332
109negative regulation of DNA-templated transcription, elongation (GO:0032785)2.92397332
110rRNA processing (GO:0006364)2.91826913
111translation (GO:0006412)2.91141524
112histone H2A acetylation (GO:0043968)2.90419806
113mitochondrial respiratory chain complex assembly (GO:0033108)2.90215300
114pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.89710257
115* respiratory chain complex IV assembly (GO:0008535)2.88879891
116regulation of ligase activity (GO:0051340)2.88744615
117protein localization to endoplasmic reticulum (GO:0070972)2.88124318
118purine nucleobase biosynthetic process (GO:0009113)2.87102979
119cellular component biogenesis (GO:0044085)2.85977727
120heart contraction (GO:0060047)2.85606951
121heart process (GO:0003015)2.85606951
122mitotic spindle checkpoint (GO:0071174)2.85199268
123protein K6-linked ubiquitination (GO:0085020)2.85119733
124ATP synthesis coupled proton transport (GO:0015986)2.85099950
125energy coupled proton transport, down electrochemical gradient (GO:0015985)2.85099950
126establishment of protein localization to endoplasmic reticulum (GO:0072599)2.84437255
127tRNA methylation (GO:0030488)2.84028352
128spindle checkpoint (GO:0031577)2.82814758
129protein localization to kinetochore (GO:0034501)2.82785394
130positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.82690337
131regulation of cellular respiration (GO:0043457)2.82606276
132mitochondrial DNA replication (GO:0006264)2.82130609
133rRNA metabolic process (GO:0016072)2.81561159
134negative regulation of myotube differentiation (GO:0010832)2.81217092
135DNA-dependent DNA replication (GO:0006261)2.80294949
136establishment of chromosome localization (GO:0051303)2.79903710
137DNA replication-independent nucleosome organization (GO:0034724)2.79688498
138DNA replication-independent nucleosome assembly (GO:0006336)2.79688498
139replication fork processing (GO:0031297)2.78080856
140rRNA methylation (GO:0031167)2.77821247
141nucleobase biosynthetic process (GO:0046112)2.77544287
142establishment of protein localization to mitochondrion (GO:0072655)2.77446207
143* respiratory electron transport chain (GO:0022904)2.76547597
144methionine biosynthetic process (GO:0009086)2.75945537
145L-methionine biosynthetic process (GO:0071265)2.75212332
146amino acid salvage (GO:0043102)2.75212332
147L-methionine salvage (GO:0071267)2.75212332
148mitotic nuclear envelope disassembly (GO:0007077)2.75197815
149protein localization to mitochondrion (GO:0070585)2.75066128
150metaphase plate congression (GO:0051310)2.73665123
151RNA methylation (GO:0001510)2.71539719
152attachment of spindle microtubules to kinetochore (GO:0008608)2.71463101
153nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.71013813
154negative regulation of ligase activity (GO:0051352)2.70044675
155negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.70044675
156base-excision repair, AP site formation (GO:0006285)2.69666893

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.97265424
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.09337448
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.95850963
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.80661734
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.72481977
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.44262461
7* GABP_17652178_ChIP-ChIP_JURKAT_Human3.44018790
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.27809182
9* EST1_17652178_ChIP-ChIP_JURKAT_Human3.24174754
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.13860041
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.04717206
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.80200540
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.75473224
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.66651358
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66467368
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.56243842
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.50632533
18VDR_23849224_ChIP-Seq_CD4+_Human2.46129255
19* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.39277940
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.35118618
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.32539004
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.28296691
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.22970970
24* YY1_21170310_ChIP-Seq_MESCs_Mouse2.22295875
25FOXP3_21729870_ChIP-Seq_TREG_Human2.18298709
26DCP1A_22483619_ChIP-Seq_HELA_Human2.13413335
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.12693233
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12113958
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.11489694
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.10377752
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.07695068
32* GABP_19822575_ChIP-Seq_HepG2_Human2.03159854
33XRN2_22483619_ChIP-Seq_HELA_Human2.02682858
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.98715497
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.98130370
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94448014
37* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.93088462
38* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.91112387
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87351005
40PADI4_21655091_ChIP-ChIP_MCF-7_Human1.86636307
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86369809
42CIITA_25753668_ChIP-Seq_RAJI_Human1.84354235
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.82993441
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.81479374
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77881836
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.74373614
47TTF2_22483619_ChIP-Seq_HELA_Human1.74088236
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.67553860
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.62712111
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61330805
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.59197076
52* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.58990478
53ZNF274_21170338_ChIP-Seq_K562_Hela1.54115736
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50731839
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44749436
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42114172
57MYC_18940864_ChIP-ChIP_HL60_Human1.39579556
58EZH2_22144423_ChIP-Seq_EOC_Human1.38769908
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38648846
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36844146
61* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36242778
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35401588
63RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33972132
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33574631
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32267217
66PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28766622
67BP1_19119308_ChIP-ChIP_Hs578T_Human1.27413104
68MYC_22102868_ChIP-Seq_BL_Human1.27311676
69HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.27282116
70SPI1_23547873_ChIP-Seq_NB4_Human1.26344736
71AR_21909140_ChIP-Seq_LNCAP_Human1.25729231
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24798002
73ELK1_19687146_ChIP-ChIP_HELA_Human1.24735322
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20907893
75VDR_21846776_ChIP-Seq_THP-1_Human1.20411496
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16190773
77HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16100263
78GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15581027
79TFEB_21752829_ChIP-Seq_HELA_Human1.13279727
80* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11814979
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11209933
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07134408
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07013279
84CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06880923
85* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04994076
86FLI1_27457419_Chip-Seq_LIVER_Mouse1.04463628
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04031531
88NANOG_16153702_ChIP-ChIP_HESCs_Human1.01567530
89KDM5A_27292631_Chip-Seq_BREAST_Human0.99410269
90FUS_26573619_Chip-Seq_HEK293_Human0.99018013
91MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98862680
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97911853
93EWS_26573619_Chip-Seq_HEK293_Human0.97260579
94* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97098335
95YY1_22570637_ChIP-Seq_MALME-3M_Human0.96245369
96EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95902677
97SOX17_20123909_ChIP-Seq_XEN_Mouse0.95823368
98CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95224408
99MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95179542
100* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93272775
101DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93067298
102SCL_19346495_ChIP-Seq_HPC-7_Human0.92443800
103GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91373299
104TP63_19390658_ChIP-ChIP_HaCaT_Human0.89677833
105STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89511755
106* ELK1_22589737_ChIP-Seq_MCF10A_Human0.88470069
107KAP1_22055183_ChIP-Seq_ESCs_Mouse0.87186609
108CTCF_18555785_ChIP-Seq_MESCs_Mouse0.87139841
109* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85543898
110KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85539247
111IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.85505912
112* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85165026
113CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.83500457
114TBX5_21415370_ChIP-Seq_HL-1_Mouse0.82317952
115PCGF2_27294783_Chip-Seq_ESCs_Mouse0.81215081
116CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80674328
117GATA4_21415370_ChIP-Seq_HL-1_Mouse0.80060867
118POU3F2_20337985_ChIP-ChIP_501MEL_Human0.79400120
119CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79091170
120RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.78482118
121LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.78094253
122IGF1R_20145208_ChIP-Seq_DFB_Human0.77490750
123VDR_22108803_ChIP-Seq_LS180_Human0.77085300
124SOX2_18555785_ChIP-Seq_MESCs_Mouse0.72653780
125TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71651049
126SOX2_16153702_ChIP-ChIP_HESCs_Human0.68280611
127TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.67280344
128HTT_18923047_ChIP-ChIP_STHdh_Human0.66777064
129DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.66616374
130ELF5_23300383_ChIP-Seq_T47D_Human0.66112574

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.25190824
2* MP0003646_muscle_fatigue3.86628167
3MP0009379_abnormal_foot_pigmentation3.33991452
4MP0010094_abnormal_chromosome_stability3.03126010
5MP0004957_abnormal_blastocyst_morpholog2.62322209
6MP0003111_abnormal_nucleus_morphology2.60413759
7MP0008058_abnormal_DNA_repair2.53190277
8MP0006292_abnormal_olfactory_placode2.51626531
9MP0003077_abnormal_cell_cycle2.50952326
10MP0003718_maternal_effect2.41431466
11MP0008260_abnormal_autophagy2.35963164
12MP0000015_abnormal_ear_pigmentation2.26114908
13MP0002396_abnormal_hematopoietic_system2.18827510
14MP0004215_abnormal_myocardial_fiber2.14065141
15MP0000749_muscle_degeneration2.12503551
16MP0005451_abnormal_body_composition2.11580680
17MP0006036_abnormal_mitochondrial_physio2.10267441
18MP0004084_abnormal_cardiac_muscle2.09308219
19MP0004233_abnormal_muscle_weight2.07230710
20MP0002837_dystrophic_cardiac_calcinosis2.05704478
21MP0003763_abnormal_thymus_physiology1.99300395
22MP0000490_abnormal_crypts_of1.97977106
23MP0005174_abnormal_tail_pigmentation1.94693743
24MP0008007_abnormal_cellular_replicative1.92707994
25MP0009333_abnormal_splenocyte_physiolog1.87113094
26MP0003950_abnormal_plasma_membrane1.83896265
27MP0001188_hyperpigmentation1.82675038
28MP0005408_hypopigmentation1.81971652
29MP0001529_abnormal_vocalization1.75955465
30MP0008932_abnormal_embryonic_tissue1.72117239
31MP0001853_heart_inflammation1.70202920
32MP0003941_abnormal_skin_development1.65049833
33MP0005075_abnormal_melanosome_morpholog1.64795907
34MP0008057_abnormal_DNA_replication1.60296509
35MP0002090_abnormal_vision1.56400443
36MP0004145_abnormal_muscle_electrophysio1.56295949
37MP0004036_abnormal_muscle_relaxation1.56115130
38MP0003786_premature_aging1.54648619
39MP0000747_muscle_weakness1.54217870
40MP0003221_abnormal_cardiomyocyte_apopto1.54049287
41MP0005330_cardiomyopathy1.53968215
42MP0002102_abnormal_ear_morphology1.48921566
43MP0002095_abnormal_skin_pigmentation1.45786982
44MP0005409_darkened_coat_color1.44955352
45MP0003828_pulmonary_edema1.44347594
46MP0009697_abnormal_copulation1.41962479
47MP0003136_yellow_coat_color1.38733306
48MP0008877_abnormal_DNA_methylation1.37986838
49MP0001986_abnormal_taste_sensitivity1.37847121
50MP0003567_abnormal_fetal_cardiomyocyte1.37533398
51MP0005645_abnormal_hypothalamus_physiol1.36493513
52MP0002638_abnormal_pupillary_reflex1.33145108
53MP0003315_abnormal_perineum_morphology1.26321691
54MP0008789_abnormal_olfactory_epithelium1.25643442
55MP0001661_extended_life_span1.22958403
56MP0001730_embryonic_growth_arrest1.22225205
57MP0006035_abnormal_mitochondrial_morpho1.21729592
58* MP0005369_muscle_phenotype1.20324104
59* MP0000759_abnormal_skeletal_muscle1.19642250
60MP0002210_abnormal_sex_determination1.17351224
61MP0001119_abnormal_female_reproductive1.17293022
62MP0001764_abnormal_homeostasis1.15833871
63MP0002938_white_spotting1.15391927
64MP0003137_abnormal_impulse_conducting1.15008447
65* MP0002106_abnormal_muscle_physiology1.14942420
66MP0000750_abnormal_muscle_regeneration1.14899260
67MP0003186_abnormal_redox_activity1.14878925
68MP0004484_altered_response_of1.12101932
69MP0008995_early_reproductive_senescence1.10615518
70* MP0000751_myopathy1.08577494
71MP0002019_abnormal_tumor_incidence1.08376875
72MP0000372_irregular_coat_pigmentation1.07679116
73MP0001697_abnormal_embryo_size1.07425816
74MP0002398_abnormal_bone_marrow1.07095590
75MP0001544_abnormal_cardiovascular_syste1.04908844
76MP0005385_cardiovascular_system_phenoty1.04908844
77MP0003724_increased_susceptibility_to1.04344902
78MP0002972_abnormal_cardiac_muscle1.04089428
79MP0002127_abnormal_cardiovascular_syste1.03731586
80MP0003806_abnormal_nucleotide_metabolis1.00798224
81MP0009785_altered_susceptibility_to0.99336675
82MP0003879_abnormal_hair_cell0.99328471
83MP0000678_abnormal_parathyroid_gland0.98520018
84MP0001929_abnormal_gametogenesis0.98283547
85MP0000689_abnormal_spleen_morphology0.97857769
86MP0005395_other_phenotype0.97809799
87MP0000343_altered_response_to0.97792422
88MP0005380_embryogenesis_phenotype0.97523213
89MP0001672_abnormal_embryogenesis/_devel0.97523213
90MP0005410_abnormal_fertilization0.96906702
91MP0005266_abnormal_metabolism0.95574622
92MP0004147_increased_porphyrin_level0.95315466
93MP0001835_abnormal_antigen_presentation0.93317797
94MP0002080_prenatal_lethality0.92608770
95MP0000313_abnormal_cell_death0.91572885
96MP0005671_abnormal_response_to0.91527938
97MP0002722_abnormal_immune_system0.91313302
98MP0005670_abnormal_white_adipose0.91095674
99MP0005332_abnormal_amino_acid0.91036371
100MP0000653_abnormal_sex_gland0.90668132
101MP0008775_abnormal_heart_ventricle0.90212577
102MP0002269_muscular_atrophy0.90051970
103* MP0004087_abnormal_muscle_fiber0.89547968
104MP0002332_abnormal_exercise_endurance0.89462847
105MP0005253_abnormal_eye_physiology0.88526942
106MP0002160_abnormal_reproductive_system0.88440199
107MP0005397_hematopoietic_system_phenotyp0.88194207
108MP0001545_abnormal_hematopoietic_system0.88194207
109MP0002132_abnormal_respiratory_system0.87488079
110MP0000049_abnormal_middle_ear0.87472919
111MP0004381_abnormal_hair_follicle0.87377921
112MP0001984_abnormal_olfaction0.87311554
113MP0000358_abnormal_cell_content/0.87166855
114MP0002163_abnormal_gland_morphology0.85481235
115MP0005620_abnormal_muscle_contractility0.84518553
116MP0002429_abnormal_blood_cell0.83502257
117MP0009672_abnormal_birth_weight0.82654878
118MP0004808_abnormal_hematopoietic_stem0.82404016
119MP0010630_abnormal_cardiac_muscle0.81827526
120MP0003699_abnormal_female_reproductive0.81596693
121MP0000703_abnormal_thymus_morphology0.80549900
122MP0003984_embryonic_growth_retardation0.80173776
123MP0001145_abnormal_male_reproductive0.80156646
124MP0000716_abnormal_immune_system0.79514182
125MP0000350_abnormal_cell_proliferation0.78987071
126MP0002088_abnormal_embryonic_growth/wei0.78893898
127MP0002148_abnormal_hypersensitivity_rea0.78419263
128MP0006138_congestive_heart_failure0.77454730
129MP0005025_abnormal_response_to0.77145625
130MP0002420_abnormal_adaptive_immunity0.77094196
131MP0001819_abnormal_immune_cell0.75462057
132MP0002085_abnormal_embryonic_tissue0.74112829
133MP0005248_abnormal_Harderian_gland0.73587551
134MP0001324_abnormal_eye_pigmentation0.70693420
135MP0003698_abnormal_male_reproductive0.68745150
136MP0003656_abnormal_erythrocyte_physiolo0.68502199
137MP0004197_abnormal_fetal_growth/weight/0.68402367
138MP0001346_abnormal_lacrimal_gland0.67866705
139MP0000579_abnormal_nail_morphology0.66732680
140MP0005367_renal/urinary_system_phenotyp0.66088670
141MP0000516_abnormal_urinary_system0.66088670
142MP0003937_abnormal_limbs/digits/tail_de0.62765210
143MP0003121_genomic_imprinting0.62203446
144MP0006072_abnormal_retinal_apoptosis0.61384719
145MP0002254_reproductive_system_inflammat0.61042584

Predicted human phenotypes

RankGene SetZ-score
1Type I transferrin isoform profile (HP:0003642)5.44403573
2Reduced antithrombin III activity (HP:0001976)5.23975044
3Muscle fiber inclusion bodies (HP:0100299)4.98049544
4Nemaline bodies (HP:0003798)4.94010395
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.87219712
6Exercise-induced muscle cramps (HP:0003710)4.53366817
7* Hepatocellular necrosis (HP:0001404)3.87546070
8* Hepatic necrosis (HP:0002605)3.76741140
9Acute necrotizing encephalopathy (HP:0006965)3.73737622
10Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.70433394
11Abnormal protein N-linked glycosylation (HP:0012347)3.70433394
12Abnormal protein glycosylation (HP:0012346)3.70433394
13Abnormal glycosylation (HP:0012345)3.70433394
14Abnormal mitochondria in muscle tissue (HP:0008316)3.60812575
15Decreased activity of mitochondrial respiratory chain (HP:0008972)3.60213171
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.60213171
17Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.59945706
18Abnormality of alanine metabolism (HP:0010916)3.59945706
19Hyperalaninemia (HP:0003348)3.59945706
20Abnormal number of erythroid precursors (HP:0012131)3.58036149
21* Mitochondrial inheritance (HP:0001427)3.53106959
22Abnormality of cells of the erythroid lineage (HP:0012130)3.47258997
23Birth length less than 3rd percentile (HP:0003561)3.44592582
24* Increased CSF lactate (HP:0002490)3.41696993
25Abnormality of glycolysis (HP:0004366)3.24032115
26* Increased serum lactate (HP:0002151)3.10333698
27Aplastic anemia (HP:0001915)3.08370167
28Reticulocytopenia (HP:0001896)3.08000843
29Increased serum pyruvate (HP:0003542)3.04095944
30* Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.03921720
31Acute encephalopathy (HP:0006846)3.03073411
32Aplasia/Hypoplasia of the sacrum (HP:0008517)2.99292320
33Type 2 muscle fiber atrophy (HP:0003554)2.90960815
34Muscle fiber atrophy (HP:0100295)2.90129988
35* Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.89038498
36Exercise-induced myalgia (HP:0003738)2.86252978
37* Lactic acidosis (HP:0003128)2.81181362
38Ventricular tachycardia (HP:0004756)2.77073443
39Progressive macrocephaly (HP:0004481)2.76900960
40Abnormality of the labia minora (HP:0012880)2.69450430
413-Methylglutaconic aciduria (HP:0003535)2.67560059
42* Exercise intolerance (HP:0003546)2.66607499
43EMG: myopathic abnormalities (HP:0003458)2.66270632
44Lipoatrophy (HP:0100578)2.63639271
45Myoglobinuria (HP:0002913)2.63157372
46Abnormality of the calf musculature (HP:0001430)2.61931433
47Severe visual impairment (HP:0001141)2.57654483
48Oral leukoplakia (HP:0002745)2.56823586
49Breast hypoplasia (HP:0003187)2.55109570
50Progressive muscle weakness (HP:0003323)2.51419912
51Methylmalonic acidemia (HP:0002912)2.49276183
52Abnormality of the left ventricular outflow tract (HP:0011103)2.48155776
53Subaortic stenosis (HP:0001682)2.48155776
54Hyperglycinemia (HP:0002154)2.44533955
55Sudden death (HP:0001699)2.43963589
56Bifid tongue (HP:0010297)2.43639637
57Abnormality of placental membranes (HP:0011409)2.43120403
58Amniotic constriction ring (HP:0009775)2.43120403
59Macrocytic anemia (HP:0001972)2.41660203
60Thyroid-stimulating hormone excess (HP:0002925)2.40296324
61* Increased intramyocellular lipid droplets (HP:0012240)2.39370198
62Pulmonary fibrosis (HP:0002206)2.37858875
63Type 1 muscle fiber predominance (HP:0003803)2.37291736
64Absent rod-and cone-mediated responses on ERG (HP:0007688)2.35939119
65Thrombocytosis (HP:0001894)2.35184352
66Chromsome breakage (HP:0040012)2.35101310
67Abnormal gallbladder physiology (HP:0012438)2.34661414
68Cholecystitis (HP:0001082)2.34661414
69Abnormality of the preputium (HP:0100587)2.32440523
70Multiple enchondromatosis (HP:0005701)2.32366481
71Nonprogressive disorder (HP:0003680)2.30898327
72* Increased muscle lipid content (HP:0009058)2.29325887
73Chromosomal breakage induced by crosslinking agents (HP:0003221)2.27325820
74Degeneration of anterior horn cells (HP:0002398)2.26835943
75Abnormality of the anterior horn cell (HP:0006802)2.26835943
76Dicarboxylic aciduria (HP:0003215)2.26832916
77Abnormality of dicarboxylic acid metabolism (HP:0010995)2.26832916
78Abnormality of serine family amino acid metabolism (HP:0010894)2.25489585
79Abnormality of glycine metabolism (HP:0010895)2.25489585
80Supraventricular tachycardia (HP:0004755)2.25266429
81Rimmed vacuoles (HP:0003805)2.25022835
82Ragged-red muscle fibers (HP:0003200)2.23845040
83Pancytopenia (HP:0001876)2.19234938
84Neck muscle weakness (HP:0000467)2.18866044
85Cerebral edema (HP:0002181)2.18165261
86* Respiratory failure (HP:0002878)2.17858705
87Abnormal lung lobation (HP:0002101)2.15655580
88Atrial fibrillation (HP:0005110)2.15278051
89Patellar aplasia (HP:0006443)2.14980465
90Microvesicular hepatic steatosis (HP:0001414)2.13993155
91Supraventricular arrhythmia (HP:0005115)2.13852447
92Abnormal spermatogenesis (HP:0008669)2.13585311
93Rhabdomyolysis (HP:0003201)2.11263637
94Abnormality of methionine metabolism (HP:0010901)2.07048882
95Hyperglycinuria (HP:0003108)2.05939529
96Optic disc pallor (HP:0000543)2.05831102
97Meckel diverticulum (HP:0002245)2.05434786
98Primary atrial arrhythmia (HP:0001692)2.05208599
99Myopathic facies (HP:0002058)2.04419221
100Calf muscle hypertrophy (HP:0008981)2.03716428
101Aplasia/Hypoplasia of the patella (HP:0006498)2.03399564
102Abnormality of serum amino acid levels (HP:0003112)2.02164004
103Aplasia/Hypoplasia of the uvula (HP:0010293)2.00638404
104Duodenal stenosis (HP:0100867)2.00261204
105Small intestinal stenosis (HP:0012848)2.00261204
106Distal arthrogryposis (HP:0005684)1.99507928
107Microretrognathia (HP:0000308)1.98450402
108Pallor (HP:0000980)1.97017163
109Neoplasm of the adrenal gland (HP:0100631)1.97005382
110Secondary amenorrhea (HP:0000869)1.95776605
111Progressive external ophthalmoplegia (HP:0000590)1.95633059
112Premature ovarian failure (HP:0008209)1.95548265
113Abnormality of the ileum (HP:0001549)1.93293289
114Testicular atrophy (HP:0000029)1.93277135
115Dilated cardiomyopathy (HP:0001644)1.91646984
116* Exertional dyspnea (HP:0002875)1.90111601
117* Renal Fanconi syndrome (HP:0001994)1.89125737
118Nephroblastoma (Wilms tumor) (HP:0002667)1.88768507
119Abnormality of aspartate family amino acid metabolism (HP:0010899)1.87072263
120Leukodystrophy (HP:0002415)1.86934656
121Sloping forehead (HP:0000340)1.86831066
122* Increased hepatocellular lipid droplets (HP:0006565)1.86356229
123Abnormality of chromosome stability (HP:0003220)1.86324858
124Muscle hypertrophy of the lower extremities (HP:0008968)1.84364290
125Petechiae (HP:0000967)1.83098458
126* Respiratory difficulties (HP:0002880)1.83077980
127IgM deficiency (HP:0002850)1.82942809
128Unsteady gait (HP:0002317)1.82885335
129True hermaphroditism (HP:0010459)1.82743693
130Palpitations (HP:0001962)1.81888254
131Elevated erythrocyte sedimentation rate (HP:0003565)1.81386133
132Lethargy (HP:0001254)1.81290864
133Abnormality of vitamin B metabolism (HP:0004340)1.80793570
134Late onset (HP:0003584)1.80501355
135* Lipid accumulation in hepatocytes (HP:0006561)1.80086450
136Shoulder girdle muscle weakness (HP:0003547)1.79547954
137Myositis (HP:0100614)1.79355737
138Abnormality of the prostate (HP:0008775)1.79085906
139Abnormality of the vitamin B12 metabolism (HP:0004341)1.78918014
140Embryonal renal neoplasm (HP:0011794)1.78229749
141Colon cancer (HP:0003003)1.77742199
142Hypothermia (HP:0002045)1.76848465
143Areflexia of lower limbs (HP:0002522)1.76801388
144Generalized aminoaciduria (HP:0002909)1.76641277
145Azoospermia (HP:0000027)1.75081440
146Abnormality of the duodenum (HP:0002246)1.73974292
147Pancreatic cysts (HP:0001737)1.73937687
148Methylmalonic aciduria (HP:0012120)1.73933051
149Limb-girdle muscle atrophy (HP:0003797)1.71443705

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.55222229
2EIF2AK34.12013515
3MUSK3.79836723
4TRIM283.44045669
5STK163.06866864
6TSSK62.93502197
7WEE12.82318068
8NME22.79672376
9MKNK22.76240891
10BUB12.65088405
11MAP4K22.58529965
12PLK42.49386453
13VRK22.48657890
14NLK2.40431630
15TLK12.29761136
16PBK2.27969233
17PDK22.11023363
18MST42.08621680
19PLK32.03370064
20IRAK31.91091328
21CDC71.90248409
22BRAF1.87430728
23PIM21.86205541
24SRPK11.69522714
25BMPR1B1.68515231
26MKNK11.63651457
27ERBB31.63621553
28ACVR1B1.63299810
29BCR1.60377438
30SIK31.60241771
31WNK31.59947651
32ARAF1.56650404
33VRK11.52610779
34EIF2AK11.52045162
35CDK81.47039112
36IRAK41.42114030
37BCKDK1.40059353
38NUAK11.40036232
39MARK31.39201317
40TEC1.30487583
41TAOK21.28680475
42CAMKK21.25940406
43OBSCN1.25407496
44EIF2AK21.23109388
45TTK1.17674635
46MAP3K61.16960278
47MYLK1.16657321
48TAOK11.16415490
49CASK1.14757366
50MAP3K111.08152284
51PLK11.05404459
52MAP2K71.05140107
53NEK21.04130321
54PINK11.03158861
55KDR1.01964665
56CSNK1G11.01463153
57KIT1.01325384
58CSNK1G31.01167629
59MAPKAPK30.98410493
60RAF10.98195929
61TTN0.97677552
62GRK10.96919094
63FES0.94472052
64MAP4K10.94012773
65ZAK0.93690486
66CDK70.90503826
67DYRK30.90477366
68NME10.86102036
69FLT30.84689503
70BRSK20.84677755
71CSNK1A1L0.81733288
72LMTK20.80749720
73BRD40.79843662
74MAP2K30.77982036
75PLK20.77799407
76AURKB0.77654531
77CDK190.75820794
78LIMK10.73893196
79PHKG10.73287534
80PHKG20.73287534
81CSNK1G20.73211326
82BTK0.72160174
83MAP3K50.70632610
84AURKA0.70572355
85MAP3K120.70261945
86CHEK10.69405301
87CDK40.68808351
88NEK10.68213139
89ABL20.67577039
90CCNB10.66667335
91DMPK0.65138372
92TXK0.64880160
93MAPK130.64696314
94CHEK20.64416232
95DYRK20.64350137
96STK38L0.63880813
97TAF10.63133691
98STK240.62439728
99RPS6KB20.60250176
100PRKD20.59264202
101MOS0.57734459
102ATM0.57137182
103CAMK10.57026135
104BMPR20.55883463
105TESK10.55636741
106ATR0.55176989
107SCYL20.54923768
108MAP3K40.51908198
109PDK30.49877073
110PDK40.49877073
111MAP3K80.49303613
112DAPK10.45808548
113CSNK2A10.45593330
114RPS6KA40.45556607
115MAPK110.43349566
116ILK0.43244137
117MAPK40.43098027
118TESK20.42208957
119PRKG20.41719244
120PIM10.41634248
121TIE10.40933309
122BRSK10.40479556
123STK100.39695600
124PKN10.39397066
125STK30.39224765
126TGFBR10.37432095
127ZAP700.36194901
128AKT20.35612801
129PAK40.34923097
130IRAK20.33582679
131PRKCI0.33364913
132CDK30.32546499
133CSNK1A10.31110802
134PAK10.30578071
135CDK10.29854491
136CSNK2A20.29460722
137LYN0.29176209
138MST1R0.29170974
139MAPKAPK50.29010267
140SYK0.28901439
141CSNK1E0.28396600
142PIK3CG0.28390630
143JAK30.28318146
144NEK90.27959499
145CDK20.27405464
146PRKACB0.24908080
147CLK10.23147507
148ERBB40.23034451
149CAMK2D0.21607473

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.06993330
2Ribosome_Homo sapiens_hsa030103.93453425
3RNA polymerase_Homo sapiens_hsa030203.67271416
4Mismatch repair_Homo sapiens_hsa034303.51811699
5Homologous recombination_Homo sapiens_hsa034403.38725321
6Base excision repair_Homo sapiens_hsa034103.12923212
7Proteasome_Homo sapiens_hsa030503.04496246
8Pyrimidine metabolism_Homo sapiens_hsa002402.76062985
9Nucleotide excision repair_Homo sapiens_hsa034202.49037576
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.40748544
11Spliceosome_Homo sapiens_hsa030402.27237330
12Parkinsons disease_Homo sapiens_hsa050122.25874812
13* Oxidative phosphorylation_Homo sapiens_hsa001902.19491527
14Basal transcription factors_Homo sapiens_hsa030222.18948596
15Fanconi anemia pathway_Homo sapiens_hsa034602.15809847
16RNA degradation_Homo sapiens_hsa030182.03631782
17Cell cycle_Homo sapiens_hsa041102.03212572
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.93967766
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91654349
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.90114548
21Huntingtons disease_Homo sapiens_hsa050161.85041596
22RNA transport_Homo sapiens_hsa030131.84598997
23Fatty acid elongation_Homo sapiens_hsa000621.83383792
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.78353847
25Purine metabolism_Homo sapiens_hsa002301.77575303
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67552120
27Non-homologous end-joining_Homo sapiens_hsa034501.60895837
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.60057795
29Protein export_Homo sapiens_hsa030601.57173421
30One carbon pool by folate_Homo sapiens_hsa006701.56859724
31Sulfur relay system_Homo sapiens_hsa041221.47026032
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46028985
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.42547262
34Alzheimers disease_Homo sapiens_hsa050101.35041826
35Steroid biosynthesis_Homo sapiens_hsa001001.33179389
36Cardiac muscle contraction_Homo sapiens_hsa042601.32680861
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.27895981
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19805756
39Selenocompound metabolism_Homo sapiens_hsa004501.15570068
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14871323
41Folate biosynthesis_Homo sapiens_hsa007901.09117452
42Thyroid cancer_Homo sapiens_hsa052161.05904928
43Circadian rhythm_Homo sapiens_hsa047101.04393778
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03009322
45N-Glycan biosynthesis_Homo sapiens_hsa005101.00840773
46Pentose phosphate pathway_Homo sapiens_hsa000301.00169395
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.99235302
48p53 signaling pathway_Homo sapiens_hsa041150.96338424
49Fatty acid metabolism_Homo sapiens_hsa012120.95385962
50Carbon metabolism_Homo sapiens_hsa012000.92334188
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90019564
52Arginine biosynthesis_Homo sapiens_hsa002200.89181834
53Regulation of autophagy_Homo sapiens_hsa041400.88311898
54Butanoate metabolism_Homo sapiens_hsa006500.87169896
55Other glycan degradation_Homo sapiens_hsa005110.86985045
56Primary immunodeficiency_Homo sapiens_hsa053400.86669532
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85257695
58Herpes simplex infection_Homo sapiens_hsa051680.84244234
59Sulfur metabolism_Homo sapiens_hsa009200.84033373
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78962974
61Biosynthesis of amino acids_Homo sapiens_hsa012300.77201053
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76864043
63Epstein-Barr virus infection_Homo sapiens_hsa051690.72815070
64Galactose metabolism_Homo sapiens_hsa000520.72326345
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70605000
66mRNA surveillance pathway_Homo sapiens_hsa030150.66761140
67Peroxisome_Homo sapiens_hsa041460.64192235
68* Metabolic pathways_Homo sapiens_hsa011000.60503594
69* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59053307
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58817993
71Vitamin B6 metabolism_Homo sapiens_hsa007500.58079258
72Arachidonic acid metabolism_Homo sapiens_hsa005900.55667117
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53221546
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52911004
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52014063
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50072128
77Fructose and mannose metabolism_Homo sapiens_hsa000510.48388710
78Propanoate metabolism_Homo sapiens_hsa006400.42893532
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42041504
80Starch and sucrose metabolism_Homo sapiens_hsa005000.41986000
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41114779
82Acute myeloid leukemia_Homo sapiens_hsa052210.40644409
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40181469
84Linoleic acid metabolism_Homo sapiens_hsa005910.39445906
85Measles_Homo sapiens_hsa051620.38629579
86beta-Alanine metabolism_Homo sapiens_hsa004100.38297357
87Arginine and proline metabolism_Homo sapiens_hsa003300.37430212
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36523337
89Glutathione metabolism_Homo sapiens_hsa004800.36261205
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36256009
91Tyrosine metabolism_Homo sapiens_hsa003500.34951738
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34240283
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.33291301
94Tryptophan metabolism_Homo sapiens_hsa003800.32842360
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.32047621
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31499700
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30687002
98Pyruvate metabolism_Homo sapiens_hsa006200.29452403
99Fat digestion and absorption_Homo sapiens_hsa049750.29360740
100Oocyte meiosis_Homo sapiens_hsa041140.28737067
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.27993159
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.27386618
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.27131275
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27081152
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26973457
106HTLV-I infection_Homo sapiens_hsa051660.26805506
107Phenylalanine metabolism_Homo sapiens_hsa003600.26714064
108Viral myocarditis_Homo sapiens_hsa054160.26667122
109Fatty acid degradation_Homo sapiens_hsa000710.26360328
110Caffeine metabolism_Homo sapiens_hsa002320.22880451
111Lysine degradation_Homo sapiens_hsa003100.21638641
112Leishmaniasis_Homo sapiens_hsa051400.20987625
113Hematopoietic cell lineage_Homo sapiens_hsa046400.20463120
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20112348
115Tight junction_Homo sapiens_hsa045300.17429444
116Collecting duct acid secretion_Homo sapiens_hsa049660.17238255
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.17163261
118Antigen processing and presentation_Homo sapiens_hsa046120.16605407
119Systemic lupus erythematosus_Homo sapiens_hsa053220.15083230
120HIF-1 signaling pathway_Homo sapiens_hsa040660.14253877
121Dilated cardiomyopathy_Homo sapiens_hsa054140.13409107
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.12790136
123Glucagon signaling pathway_Homo sapiens_hsa049220.12556441
124Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.11857586
125Apoptosis_Homo sapiens_hsa042100.10868251
126Cyanoamino acid metabolism_Homo sapiens_hsa004600.10826367
127Legionellosis_Homo sapiens_hsa051340.10435076
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.10354580
129Hepatitis B_Homo sapiens_hsa051610.10349506
130Asthma_Homo sapiens_hsa053100.09814198
131Colorectal cancer_Homo sapiens_hsa052100.09246589
132Influenza A_Homo sapiens_hsa051640.08336432
133Nitrogen metabolism_Homo sapiens_hsa009100.07919404
134Sphingolipid metabolism_Homo sapiens_hsa006000.07909841
135Vitamin digestion and absorption_Homo sapiens_hsa049770.07406362

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