COX11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kinetochore assembly (GO:0051382)4.98236638
2kinetochore organization (GO:0051383)4.88740796
3CENP-A containing nucleosome assembly (GO:0034080)4.58777005
4chromatin remodeling at centromere (GO:0031055)4.45839258
5DNA deamination (GO:0045006)4.29505034
6rRNA modification (GO:0000154)4.27058969
7regulation of nuclear cell cycle DNA replication (GO:0033262)4.19068077
8telomere maintenance via semi-conservative replication (GO:0032201)4.09940034
9rRNA methylation (GO:0031167)4.04899646
10quinone biosynthetic process (GO:1901663)4.04592048
11ubiquinone biosynthetic process (GO:0006744)4.04592048
12DNA replication initiation (GO:0006270)4.04498217
13purine nucleobase biosynthetic process (GO:0009113)4.04104841
14proteasome assembly (GO:0043248)4.00543741
15response to pheromone (GO:0019236)3.98302245
16transcription from mitochondrial promoter (GO:0006390)3.96255980
17histone exchange (GO:0043486)3.95033055
18DNA strand elongation involved in DNA replication (GO:0006271)3.86696906
19nucleobase biosynthetic process (GO:0046112)3.84695144
20DNA replication-independent nucleosome assembly (GO:0006336)3.77007139
21DNA replication-independent nucleosome organization (GO:0034724)3.77007139
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.75057456
23DNA strand elongation (GO:0022616)3.75038754
24DNA double-strand break processing (GO:0000729)3.73485497
25ubiquinone metabolic process (GO:0006743)3.68599362
26telomere maintenance via recombination (GO:0000722)3.60653750
27deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.60389234
28tRNA methylation (GO:0030488)3.55883094
29mitochondrial RNA metabolic process (GO:0000959)3.53828346
30ribosome biogenesis (GO:0042254)3.44824874
317-methylguanosine mRNA capping (GO:0006370)3.40680961
32DNA replication checkpoint (GO:0000076)3.39544903
33RNA capping (GO:0036260)3.32375391
347-methylguanosine RNA capping (GO:0009452)3.32375391
35regulation of mitochondrial translation (GO:0070129)3.31278325
36oxaloacetate metabolic process (GO:0006107)3.30511068
37mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.29343377
38protein complex biogenesis (GO:0070271)3.28028923
39water-soluble vitamin biosynthetic process (GO:0042364)3.26875727
40RNA methylation (GO:0001510)3.25199025
41replication fork processing (GO:0031297)3.25006416
42deoxyribose phosphate biosynthetic process (GO:0046385)3.24984955
432-deoxyribonucleotide biosynthetic process (GO:0009265)3.24984955
44mitochondrial respiratory chain complex assembly (GO:0033108)3.21693408
45mitotic recombination (GO:0006312)3.21473014
46ATP synthesis coupled proton transport (GO:0015986)3.21205478
47energy coupled proton transport, down electrochemical gradient (GO:0015985)3.21205478
48nucleobase-containing small molecule interconversion (GO:0015949)3.12538756
49pseudouridine synthesis (GO:0001522)3.11312529
50protein neddylation (GO:0045116)3.09508970
51* respiratory chain complex IV assembly (GO:0008535)3.08005812
52ribosomal small subunit assembly (GO:0000028)3.06165377
53cullin deneddylation (GO:0010388)3.05307207
54deoxyribonucleotide biosynthetic process (GO:0009263)3.04140624
55formation of translation preinitiation complex (GO:0001731)3.03531006
56respiratory electron transport chain (GO:0022904)2.99592268
57isotype switching (GO:0045190)2.99501812
58somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.99501812
59somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.99501812
60telomere maintenance via telomere lengthening (GO:0010833)2.97228050
61mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.97109894
62mitochondrial respiratory chain complex I assembly (GO:0032981)2.97109894
63NADH dehydrogenase complex assembly (GO:0010257)2.97109894
64peptidyl-histidine modification (GO:0018202)2.96748081
65quinone metabolic process (GO:1901661)2.95691864
66electron transport chain (GO:0022900)2.95120987
67negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.95084558
68pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.93962464
69oxidative phosphorylation (GO:0006119)2.93659963
70transcription-coupled nucleotide-excision repair (GO:0006283)2.93498535
71DNA damage response, detection of DNA damage (GO:0042769)2.92679446
72meiotic chromosome segregation (GO:0045132)2.92570456
73establishment of integrated proviral latency (GO:0075713)2.91439399
74termination of RNA polymerase III transcription (GO:0006386)2.91418734
75transcription elongation from RNA polymerase III promoter (GO:0006385)2.91418734
76regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.89686518
77deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.89467510
78establishment of protein localization to mitochondrial membrane (GO:0090151)2.87853901
79positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.87735505
80attachment of spindle microtubules to kinetochore (GO:0008608)2.87128651
81maturation of 5.8S rRNA (GO:0000460)2.86328408
82* cytochrome complex assembly (GO:0017004)2.86082628
83L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.85441652
84tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.85099992
85RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.85099992
86piRNA metabolic process (GO:0034587)2.84222939
87branched-chain amino acid catabolic process (GO:0009083)2.82731508
88signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.82497319
89signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.82497319
90signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.82497319
91IMP biosynthetic process (GO:0006188)2.82117322
92regulation of double-strand break repair via homologous recombination (GO:0010569)2.81959370
93anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.80751746
94protein deneddylation (GO:0000338)2.80747564
95DNA unwinding involved in DNA replication (GO:0006268)2.78945977
96regulation of cellular amino acid metabolic process (GO:0006521)2.78629774
97regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.78470598
98mitotic metaphase plate congression (GO:0007080)2.78052593
99DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.77982949
100folic acid-containing compound biosynthetic process (GO:0009396)2.77358285
101antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.77177309
102chaperone-mediated protein transport (GO:0072321)2.76259250
103signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.74506888
104intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.74506888
105protein autoprocessing (GO:0016540)2.74255352
106maturation of SSU-rRNA (GO:0030490)2.73827722
107metallo-sulfur cluster assembly (GO:0031163)2.73716975
108iron-sulfur cluster assembly (GO:0016226)2.73716975
109pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.72850285
110nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.71219303
111L-methionine salvage (GO:0071267)2.70935727
112L-methionine biosynthetic process (GO:0071265)2.70935727
113amino acid salvage (GO:0043102)2.70935727
114ribonucleoprotein complex biogenesis (GO:0022613)2.69613168
115signal transduction involved in DNA integrity checkpoint (GO:0072401)2.69030850
116signal transduction involved in DNA damage checkpoint (GO:0072422)2.69030850
117energy homeostasis (GO:0097009)2.68958165
118signal transduction involved in cell cycle checkpoint (GO:0072395)2.68673836
119regulation of helicase activity (GO:0051095)2.68664063
120negative regulation of DNA-templated transcription, elongation (GO:0032785)2.67083506
121negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.67083506
122nucleotide-excision repair, DNA gap filling (GO:0006297)2.66873575
123exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66576301
124antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.65151364
125snRNA processing (GO:0016180)2.64583573
126somatic hypermutation of immunoglobulin genes (GO:0016446)2.64060453
127somatic diversification of immune receptors via somatic mutation (GO:0002566)2.64060453
128DNA replication-dependent nucleosome assembly (GO:0006335)2.63576710
129DNA replication-dependent nucleosome organization (GO:0034723)2.63576710
130spliceosomal snRNP assembly (GO:0000387)2.63458836
131pyrimidine nucleotide catabolic process (GO:0006244)2.62518021
132pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.62462075
133ATP-dependent chromatin remodeling (GO:0043044)2.62153424
134cell cycle G1/S phase transition (GO:0044843)2.61389954
135G1/S transition of mitotic cell cycle (GO:0000082)2.61389954
136ribosome assembly (GO:0042255)2.61279971
137maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.60882171
138DNA catabolic process, exonucleolytic (GO:0000738)2.60658906
139protein targeting to mitochondrion (GO:0006626)2.60102397
140regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.59598675
141regulation of mitotic spindle checkpoint (GO:1903504)2.59598675
142postreplication repair (GO:0006301)2.50415769
143regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.47365970
144pteridine-containing compound biosynthetic process (GO:0042559)2.46058688
145resolution of meiotic recombination intermediates (GO:0000712)2.43610036
146establishment of protein localization to mitochondrion (GO:0072655)2.41089052
147protein localization to mitochondrion (GO:0070585)2.40304671
148double-strand break repair via nonhomologous end joining (GO:0006303)2.38804319
149non-recombinational repair (GO:0000726)2.38804319
150protein prenylation (GO:0018342)2.36668648
151prenylation (GO:0097354)2.36668648
152aspartate family amino acid biosynthetic process (GO:0009067)2.34225051
153* regulation of hexokinase activity (GO:1903299)2.33721459
154* regulation of glucokinase activity (GO:0033131)2.33721459
155methionine biosynthetic process (GO:0009086)2.33554670
156tRNA processing (GO:0008033)2.32685640
157tRNA metabolic process (GO:0006399)2.29365895
158RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.27370822
159histone H2A acetylation (GO:0043968)2.26961667
160regulation of centriole replication (GO:0046599)2.26435850
161regulation of acyl-CoA biosynthetic process (GO:0050812)2.26184765
162mannosylation (GO:0097502)2.25485722
163aspartate family amino acid catabolic process (GO:0009068)2.25133105
164L-serine metabolic process (GO:0006563)2.22467563
165methionine metabolic process (GO:0006555)2.22145879

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.30829276
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.34717242
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.95352192
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.69807551
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.47563597
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.96302027
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.95645434
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.87676891
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.83129936
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.82016568
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.81705468
12* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.78412491
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.67012788
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.62965435
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.51294672
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.50699508
17VDR_23849224_ChIP-Seq_CD4+_Human2.50675587
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.48715090
19ZNF274_21170338_ChIP-Seq_K562_Hela2.44104502
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.40265723
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.37116817
22IGF1R_20145208_ChIP-Seq_DFB_Human2.30817459
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.30591400
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.29928695
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28922126
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.27004816
27BP1_19119308_ChIP-ChIP_Hs578T_Human2.19566902
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.18334344
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.17189580
30SALL1_21062744_ChIP-ChIP_HESCs_Human2.17040768
31GATA1_22025678_ChIP-Seq_K562_Human2.16416618
32POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14609570
33FUS_26573619_Chip-Seq_HEK293_Human2.14052724
34NOTCH1_21737748_ChIP-Seq_TLL_Human2.10091497
35* EWS_26573619_Chip-Seq_HEK293_Human2.08952678
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.07219478
37NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06688472
38YY1_21170310_ChIP-Seq_MESCs_Mouse2.06083135
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.99867925
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.96966211
41* XRN2_22483619_ChIP-Seq_HELA_Human1.94216784
42FOXP3_21729870_ChIP-Seq_TREG_Human1.93284375
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93156232
44VDR_22108803_ChIP-Seq_LS180_Human1.93041446
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.91418377
46ELK1_19687146_ChIP-ChIP_HELA_Human1.88393489
47AR_21909140_ChIP-Seq_LNCAP_Human1.82459106
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82270439
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.77845235
50* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76492532
51DCP1A_22483619_ChIP-Seq_HELA_Human1.76336859
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75927555
53GABP_19822575_ChIP-Seq_HepG2_Human1.75422762
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.73642134
55TTF2_22483619_ChIP-Seq_HELA_Human1.72126218
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71642100
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69913093
58TAF15_26573619_Chip-Seq_HEK293_Human1.69129371
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63317865
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62854297
61CIITA_25753668_ChIP-Seq_RAJI_Human1.58208776
62* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.56196962
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54143430
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50065723
65IRF8_22096565_ChIP-ChIP_GC-B_Human1.49151828
66* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.47821749
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44532662
68IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.44357499
69P300_19829295_ChIP-Seq_ESCs_Human1.43937555
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32306539
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30521999
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29053986
73MYC_18940864_ChIP-ChIP_HL60_Human1.28409973
74GBX2_23144817_ChIP-Seq_PC3_Human1.26865571
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.25545768
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25122398
77SPI1_23547873_ChIP-Seq_NB4_Human1.23373293
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23067018
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22717024
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.22092516
81NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22090627
82SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20037560
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19146847
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18492082
85* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17038076
86ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15606749
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15410711
88* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10891843
89NANOG_16153702_ChIP-ChIP_HESCs_Human1.08042966
90* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07493615
91HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06812273
92POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06524605
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04064941
94KDM5A_27292631_Chip-Seq_BREAST_Human1.03072357
95TP53_22573176_ChIP-Seq_HFKS_Human1.01920787
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01124618
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00487056
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00304862
99IRF1_19129219_ChIP-ChIP_H3396_Human1.00189598
100ER_23166858_ChIP-Seq_MCF-7_Human0.99793940
101SOX2_16153702_ChIP-ChIP_HESCs_Human0.99573392
102PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99456229
103CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98308140
104KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97034936
105CBP_20019798_ChIP-Seq_JUKART_Human0.96211830
106IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96211830
107SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95046089
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95027397
109KAP1_22055183_ChIP-Seq_ESCs_Mouse0.94631996
110TFEB_21752829_ChIP-Seq_HELA_Human0.94527497
111SCL_19346495_ChIP-Seq_HPC-7_Human0.94400297
112CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93341808
113ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93300729
114RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92939974
115LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92791552
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92162019
117GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91972224
118EZH2_27294783_Chip-Seq_NPCs_Mouse0.91410226
119ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91066229
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91000968
121UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90972496
122FLI1_27457419_Chip-Seq_LIVER_Mouse0.90947175
123CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90857296
124GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89861009
125NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.89839311
126MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.87397486
127HTT_18923047_ChIP-ChIP_STHdh_Human0.87222368
128TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87142805
129ELK1_22589737_ChIP-Seq_MCF10A_Human0.85505940
130NANOG_19829295_ChIP-Seq_ESCs_Human0.85251964
131CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84626835
132SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84041737
133STAT4_19710469_ChIP-ChIP_TH1__Mouse0.83704988
134CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83535530
135TP63_19390658_ChIP-ChIP_HaCaT_Human0.83515798
136EGR1_23403033_ChIP-Seq_LIVER_Mouse0.82637514
137IRF8_21731497_ChIP-ChIP_J774_Mouse0.78157379
138GATA4_21415370_ChIP-Seq_HL-1_Mouse0.77599757
139MYC_22102868_ChIP-Seq_BL_Human0.77148648
140HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.76319920
141BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.74991650
142SOX2_18555785_ChIP-Seq_MESCs_Mouse0.74194075
143PU.1_20513432_ChIP-Seq_Bcells_Mouse0.74098997

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.23083489
2MP0003693_abnormal_embryo_hatching4.67192799
3MP0008058_abnormal_DNA_repair3.65593769
4MP0010094_abnormal_chromosome_stability3.48305800
5MP0003111_abnormal_nucleus_morphology3.39482443
6MP0004147_increased_porphyrin_level3.26758450
7MP0004957_abnormal_blastocyst_morpholog3.06434453
8MP0003077_abnormal_cell_cycle2.98082043
9MP0003806_abnormal_nucleotide_metabolis2.95020535
10MP0008007_abnormal_cellular_replicative2.77458741
11MP0006292_abnormal_olfactory_placode2.56403484
12MP0002396_abnormal_hematopoietic_system2.37918247
13MP0009697_abnormal_copulation2.21008857
14MP0008877_abnormal_DNA_methylation2.11528728
15MP0003763_abnormal_thymus_physiology2.10406481
16MP0000490_abnormal_crypts_of2.06565506
17MP0001835_abnormal_antigen_presentation2.04983657
18MP0003786_premature_aging2.04671785
19MP0003787_abnormal_imprinting2.02890379
20MP0005671_abnormal_response_to1.99230809
21MP0001529_abnormal_vocalization1.94517280
22MP0003195_calcinosis1.88458945
23MP0006036_abnormal_mitochondrial_physio1.83587864
24MP0001545_abnormal_hematopoietic_system1.83017072
25MP0005397_hematopoietic_system_phenotyp1.83017072
26MP0003880_abnormal_central_pattern1.76403487
27MP0006072_abnormal_retinal_apoptosis1.74298144
28MP0003121_genomic_imprinting1.72521878
29MP0003122_maternal_imprinting1.70597734
30MP0003890_abnormal_embryonic-extraembry1.69838619
31MP0009785_altered_susceptibility_to1.66894681
32MP0002638_abnormal_pupillary_reflex1.61383528
33MP0008932_abnormal_embryonic_tissue1.60566415
34MP0003724_increased_susceptibility_to1.56538202
35MP0002837_dystrophic_cardiac_calcinosis1.53191445
36MP0005084_abnormal_gallbladder_morpholo1.50189180
37MP0001984_abnormal_olfaction1.48844724
38MP0002398_abnormal_bone_marrow1.48792574
39MP0003186_abnormal_redox_activity1.48132759
40MP0002210_abnormal_sex_determination1.48075966
41MP0000015_abnormal_ear_pigmentation1.44932030
42MP0005075_abnormal_melanosome_morpholog1.43819514
43MP0003656_abnormal_erythrocyte_physiolo1.41917163
44MP0005551_abnormal_eye_electrophysiolog1.41375807
45MP0001853_heart_inflammation1.40831986
46MP0005332_abnormal_amino_acid1.36023962
47MP0002160_abnormal_reproductive_system1.34648324
48MP0006054_spinal_hemorrhage1.33830281
49MP0008789_abnormal_olfactory_epithelium1.33583591
50MP0002876_abnormal_thyroid_physiology1.33061979
51MP0003123_paternal_imprinting1.32689633
52MP0005646_abnormal_pituitary_gland1.31101598
53MP0002234_abnormal_pharynx_morphology1.31059961
54MP0001929_abnormal_gametogenesis1.30419224
55MP0004133_heterotaxia1.30351590
56MP0000350_abnormal_cell_proliferation1.27463008
57MP0000685_abnormal_immune_system1.26751810
58MP0004215_abnormal_myocardial_fiber1.26441468
59MP0003937_abnormal_limbs/digits/tail_de1.25083857
60MP0008875_abnormal_xenobiotic_pharmacok1.24565777
61MP0000689_abnormal_spleen_morphology1.24524792
62MP0000313_abnormal_cell_death1.24383674
63MP0005085_abnormal_gallbladder_physiolo1.23728952
64MP0001119_abnormal_female_reproductive1.23721878
65MP0003718_maternal_effect1.23546711
66MP0003136_yellow_coat_color1.19123973
67MP0001293_anophthalmia1.18879886
68MP0005253_abnormal_eye_physiology1.18298825
69MP0005670_abnormal_white_adipose1.16956474
70MP0001145_abnormal_male_reproductive1.16595007
71MP0009333_abnormal_splenocyte_physiolog1.15206624
72MP0002723_abnormal_immune_serum1.15025336
73MP0009046_muscle_twitch1.14364629
74MP0002429_abnormal_blood_cell1.14199186
75MP0005645_abnormal_hypothalamus_physiol1.14045107
76MP0005025_abnormal_response_to1.14040816
77MP0001188_hyperpigmentation1.13727179
78MP0003567_abnormal_fetal_cardiomyocyte1.13710840
79MP0008995_early_reproductive_senescence1.13534303
80MP0002139_abnormal_hepatobiliary_system1.13460959
81MP0002736_abnormal_nociception_after1.13436926
82MP0005187_abnormal_penis_morphology1.13024358
83MP0004043_abnormal_pH_regulation1.12971755
84MP0002148_abnormal_hypersensitivity_rea1.12496322
85MP0000569_abnormal_digit_pigmentation1.11434105
86MP0000716_abnormal_immune_system1.10521568
87MP0008872_abnormal_physiological_respon1.10154545
88MP0002722_abnormal_immune_system1.10069492
89MP0000631_abnormal_neuroendocrine_gland1.09530342
90MP0002019_abnormal_tumor_incidence1.09433355
91MP0006035_abnormal_mitochondrial_morpho1.09283811
92MP0005377_hearing/vestibular/ear_phenot1.08853190
93MP0003878_abnormal_ear_physiology1.08853190
94MP0003646_muscle_fatigue1.08720205
95MP0006276_abnormal_autonomic_nervous1.06332039
96MP0001800_abnormal_humoral_immune1.04982306
97MP0005365_abnormal_bile_salt1.04727455
98MP0005367_renal/urinary_system_phenotyp1.04076543
99MP0000516_abnormal_urinary_system1.04076543
100MP0003252_abnormal_bile_duct1.04028063
101MP0000653_abnormal_sex_gland1.03654986
102MP0002420_abnormal_adaptive_immunity1.01807900
103MP0000372_irregular_coat_pigmentation1.01654222
104MP0001819_abnormal_immune_cell1.01193487
105MP0000703_abnormal_thymus_morphology0.99735714
106MP0009780_abnormal_chondrocyte_physiolo0.99529270
107MP0002132_abnormal_respiratory_system0.99292672
108MP0004145_abnormal_muscle_electrophysio0.99130913
109MP0002452_abnormal_antigen_presenting0.98184970
110MP0005394_taste/olfaction_phenotype0.98000523
111MP0005499_abnormal_olfactory_system0.98000523
112MP0001968_abnormal_touch/_nociception0.97860628
113MP0001764_abnormal_homeostasis0.97077851
114MP0005000_abnormal_immune_tolerance0.96776370
115MP0005266_abnormal_metabolism0.95718864
116MP0001730_embryonic_growth_arrest0.95665971
117MP0009764_decreased_sensitivity_to0.94412357
118MP0005389_reproductive_system_phenotype0.94024348
119MP0003119_abnormal_digestive_system0.92757173
120MP0002102_abnormal_ear_morphology0.92123598
121MP0002233_abnormal_nose_morphology0.91776069
122MP0005379_endocrine/exocrine_gland_phen0.91357484
123MP0003436_decreased_susceptibility_to0.90143477
124MP0009379_abnormal_foot_pigmentation0.90035342
125MP0001873_stomach_inflammation0.88194775
126MP0001661_extended_life_span0.87779942
127MP0005220_abnormal_exocrine_pancreas0.85412672
128MP0003011_delayed_dark_adaptation0.84614944
129MP0002272_abnormal_nervous_system0.84570625
130MP0005174_abnormal_tail_pigmentation0.83791741
131MP0002095_abnormal_skin_pigmentation0.83283627
132MP0005647_abnormal_sex_gland0.83171894
133MP0002090_abnormal_vision0.82861627
134MP0002419_abnormal_innate_immunity0.81672708
135MP0002084_abnormal_developmental_patter0.79493086
136MP0002822_catalepsy0.79304075
137MP0003137_abnormal_impulse_conducting0.76899020
138MP0002557_abnormal_social/conspecific_i0.76860413
139MP0004142_abnormal_muscle_tone0.76594418
140MP0008260_abnormal_autophagy0.75696239
141MP0001286_abnormal_eye_development0.75658209
142MP0003698_abnormal_male_reproductive0.75174378
143MP0003283_abnormal_digestive_organ0.75069019
144MP0004924_abnormal_behavior0.74049839
145MP0005386_behavior/neurological_phenoty0.74049839
146MP0003943_abnormal_hepatobiliary_system0.73366337
147MP0002184_abnormal_innervation0.73335572
148MP0004808_abnormal_hematopoietic_stem0.72764461
149MP0002751_abnormal_autonomic_nervous0.72635577
150MP0008469_abnormal_protein_level0.72457929
151MP0000013_abnormal_adipose_tissue0.72207756
152MP0001845_abnormal_inflammatory_respons0.72140920
153MP0005636_abnormal_mineral_homeostasis0.71928012
154MP0002938_white_spotting0.71870741
155MP0010352_gastrointestinal_tract_polyps0.70066828
156MP0002163_abnormal_gland_morphology0.69833934
157MP0001672_abnormal_embryogenesis/_devel0.65723678
158MP0005380_embryogenesis_phenotype0.65723678
159MP0000343_altered_response_to0.65140952
160MP0002080_prenatal_lethality0.65050053
161MP0001697_abnormal_embryo_size0.63417206
162MP0010155_abnormal_intestine_physiology0.63291446

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)4.10589467
2Aplastic anemia (HP:0001915)3.82154757
3Chromsome breakage (HP:0040012)3.70680449
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.65000441
5Type I transferrin isoform profile (HP:0003642)3.47113878
6Abnormality of the fovea (HP:0000493)3.25406365
7Birth length less than 3rd percentile (HP:0003561)3.07514440
8Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.07321951
9Abnormality of alanine metabolism (HP:0010916)3.07321951
10Hyperalaninemia (HP:0003348)3.07321951
11Meckel diverticulum (HP:0002245)3.04605930
12Petechiae (HP:0000967)3.04115314
13Abnormality of the ileum (HP:0001549)2.95543333
14Acute necrotizing encephalopathy (HP:0006965)2.93230485
15Hepatic necrosis (HP:0002605)2.91470699
16Hyperinsulinemic hypoglycemia (HP:0000825)2.84942620
17Abnormal mitochondria in muscle tissue (HP:0008316)2.82974463
18Hyperglycinuria (HP:0003108)2.81413586
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.79481158
20Decreased activity of mitochondrial respiratory chain (HP:0008972)2.79481158
21Increased serum lactate (HP:0002151)2.74949865
22Aplasia/Hypoplasia of the uvula (HP:0010293)2.74668148
23Abnormal number of erythroid precursors (HP:0012131)2.72188509
24Degeneration of anterior horn cells (HP:0002398)2.69410566
25Abnormality of the anterior horn cell (HP:0006802)2.69410566
26Pancytopenia (HP:0001876)2.69323033
27Increased CSF lactate (HP:0002490)2.66079183
28Colon cancer (HP:0003003)2.65528331
29Abnormality of glycine metabolism (HP:0010895)2.64756347
30Abnormality of serine family amino acid metabolism (HP:0010894)2.64756347
31Abnormality of the preputium (HP:0100587)2.64323462
32Hyperglycinemia (HP:0002154)2.63682255
33Hepatocellular necrosis (HP:0001404)2.62169772
34Reduced antithrombin III activity (HP:0001976)2.60969835
35Unilateral renal agenesis (HP:0000122)2.59450682
36Abnormality of chromosome stability (HP:0003220)2.55540728
37Pancreatic fibrosis (HP:0100732)2.53551447
38Pancreatic cysts (HP:0001737)2.50030731
39Acute encephalopathy (HP:0006846)2.48561085
40Abnormality of cells of the erythroid lineage (HP:0012130)2.44675916
41Hypoglycemic coma (HP:0001325)2.39972568
42Absent rod-and cone-mediated responses on ERG (HP:0007688)2.39148460
43Molar tooth sign on MRI (HP:0002419)2.38869811
44Abnormality of midbrain morphology (HP:0002418)2.38869811
45Mitochondrial inheritance (HP:0001427)2.38512145
46Aplasia/Hypoplasia of the fovea (HP:0008060)2.35529170
47Hypoplasia of the fovea (HP:0007750)2.35529170
48Nausea (HP:0002018)2.35528003
49Methylmalonic aciduria (HP:0012120)2.33426975
50Abnormality of serum amino acid levels (HP:0003112)2.29337628
51Nephronophthisis (HP:0000090)2.28219867
52Abnormality of the labia minora (HP:0012880)2.27609587
53Abnormality of methionine metabolism (HP:0010901)2.27061114
54Dicarboxylic aciduria (HP:0003215)2.26217073
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.26217073
56Lactic acidosis (HP:0003128)2.24539917
57Abnormality of urine glucose concentration (HP:0011016)2.22363514
58Glycosuria (HP:0003076)2.22363514
59Medial flaring of the eyebrow (HP:0010747)2.21291553
60Bone marrow hypocellularity (HP:0005528)2.21246790
6111 pairs of ribs (HP:0000878)2.21232769
623-Methylglutaconic aciduria (HP:0003535)2.20226316
63Renal Fanconi syndrome (HP:0001994)2.19761693
64True hermaphroditism (HP:0010459)2.19365878
65Abnormal spermatogenesis (HP:0008669)2.18540679
66Increased serum pyruvate (HP:0003542)2.18104169
67Exercise intolerance (HP:0003546)2.17700932
68Generalized aminoaciduria (HP:0002909)2.14965398
69Panhypogammaglobulinemia (HP:0003139)2.14765638
70Abnormality of the renal cortex (HP:0011035)2.13412195
71Type 2 muscle fiber atrophy (HP:0003554)2.13129674
72Methylmalonic acidemia (HP:0002912)2.11853816
73Progressive macrocephaly (HP:0004481)2.10891216
74Reticulocytopenia (HP:0001896)2.10146480
75Azoospermia (HP:0000027)2.09342201
76Respiratory failure (HP:0002878)2.08730893
77Abnormal protein glycosylation (HP:0012346)2.08261463
78Abnormal glycosylation (HP:0012345)2.08261463
79Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.08261463
80Abnormal protein N-linked glycosylation (HP:0012347)2.08261463
81Pancreatic islet-cell hyperplasia (HP:0004510)2.08101439
82Microvesicular hepatic steatosis (HP:0001414)2.07811156
83Abnormality of vitamin B metabolism (HP:0004340)2.07405434
84Septo-optic dysplasia (HP:0100842)2.06739493
85Ketoacidosis (HP:0001993)2.05388774
86Volvulus (HP:0002580)2.04409070
87Abnormality of fatty-acid metabolism (HP:0004359)2.03747866
88Abnormality of aspartate family amino acid metabolism (HP:0010899)2.02034462
89Microretrognathia (HP:0000308)2.01785143
90Lethargy (HP:0001254)2.00654163
91IgM deficiency (HP:0002850)2.00370550
92Carpal bone hypoplasia (HP:0001498)1.99788738
93Abnormality of glycolysis (HP:0004366)1.99711708
94Increased intramyocellular lipid droplets (HP:0012240)1.99135265
95Cerebral edema (HP:0002181)1.99078455
96Neoplasm of the adrenal gland (HP:0100631)1.99057136
97Rough bone trabeculation (HP:0100670)1.98538241
98Small intestinal stenosis (HP:0012848)1.97473102
99Duodenal stenosis (HP:0100867)1.97473102
100Respiratory difficulties (HP:0002880)1.96889302
101Congenital primary aphakia (HP:0007707)1.96327432
102Hypoplasia of the thymus (HP:0000778)1.96199064
103Abnormality of the vitamin B12 metabolism (HP:0004341)1.95701941
104Abnormality of T cell physiology (HP:0011840)1.95335162
105Muscle fiber atrophy (HP:0100295)1.95159970
106Short middle phalanx of the 5th finger (HP:0004220)1.94898113
107Clubbing of toes (HP:0100760)1.93668771
108Agnosia (HP:0010524)1.93454889
109Abnormality of the renal medulla (HP:0100957)1.92408070
110Hypobetalipoproteinemia (HP:0003563)1.90690297
111Oral leukoplakia (HP:0002745)1.89753230
112Increased hepatocellular lipid droplets (HP:0006565)1.89286369
113Lipid accumulation in hepatocytes (HP:0006561)1.88411849
114Abnormality of pyrimidine metabolism (HP:0004353)1.88102759
115Abnormality of DNA repair (HP:0003254)1.87809457
116Encephalitis (HP:0002383)1.85800901
117Recurrent abscess formation (HP:0002722)1.85428982
118Gait imbalance (HP:0002141)1.85225898
119Renal cortical cysts (HP:0000803)1.84226587
120Aplasia/Hypoplasia of the tibia (HP:0005772)1.83482612
121Nephrogenic diabetes insipidus (HP:0009806)1.82882317
122Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.82411822
123Neutropenia (HP:0001875)1.81634307
124Triphalangeal thumb (HP:0001199)1.81391305
125Hypothermia (HP:0002045)1.80816999
126Impulsivity (HP:0100710)1.79359842
127Optic disc pallor (HP:0000543)1.78790163
128Absent thumb (HP:0009777)1.78584846
129Maternal diabetes (HP:0009800)1.78493485
130Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.78081954
131Thrombocytosis (HP:0001894)1.77735105
132CNS demyelination (HP:0007305)1.77493741
133Leukodystrophy (HP:0002415)1.75616887
134Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.75438693
135Hypomagnesemia (HP:0002917)1.74931428
136Progressive muscle weakness (HP:0003323)1.74612477
137Hypoglycemic seizures (HP:0002173)1.74090235
138Myelodysplasia (HP:0002863)1.74070605
139Megaloblastic anemia (HP:0001889)1.73901994
140Genital tract atresia (HP:0001827)1.73198057
141Abnormality of the carotid arteries (HP:0005344)1.72311362
142Lymphoma (HP:0002665)1.69074843
143Bile duct proliferation (HP:0001408)1.68699162
144Abnormal biliary tract physiology (HP:0012439)1.68699162
145Vaginal atresia (HP:0000148)1.68662638
146Increased IgM level (HP:0003496)1.68229022
147Sclerocornea (HP:0000647)1.67964087
148Ketosis (HP:0001946)1.66195944
149Prolonged partial thromboplastin time (HP:0003645)1.65763953
150Hyperphosphaturia (HP:0003109)1.65185895
151Prominent metopic ridge (HP:0005487)1.63308137
152Exercise-induced muscle cramps (HP:0003710)1.63283461
153Supernumerary spleens (HP:0009799)1.62720151
154Neuroendocrine neoplasm (HP:0100634)1.62544008
155Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.62387556
156Hypoplasia of the pons (HP:0012110)1.62307512
157Abnormality of the pons (HP:0007361)1.59562019

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B6.25167378
2INSRR3.50881153
3FRK3.34063447
4NEK22.84956939
5NEK12.80067673
6TXK2.79085801
7TRIM282.75064011
8STK162.74594399
9WEE12.64246877
10ZAK2.57957949
11WNK32.51853142
12IRAK32.46676833
13CDC72.45275897
14EIF2AK12.44345067
15NUAK12.40527881
16EIF2AK32.31719724
17VRK22.29286239
18PBK2.29046733
19DYRK32.21994864
20MAP2K72.15805956
21TEC1.99368244
22MAP4K21.98990397
23BUB11.93744265
24NME21.93213345
25BMPR1B1.81355849
26TNIK1.63346111
27TIE11.60297826
28BCR1.59065780
29MAP3K41.57603306
30CSNK1G31.57068967
31SCYL21.54575228
32PIM21.54511598
33BRSK21.53987371
34VRK11.48697812
35CSNK1G11.48536052
36EIF2AK21.43974782
37EPHA41.41840162
38MKNK21.41736232
39CSNK1G21.39719949
40PLK11.39463423
41MST41.38095929
42AURKB1.34133556
43TSSK61.33600244
44CSNK1A1L1.29058845
45MAP4K11.28781117
46SRPK11.27184999
47FGFR21.25283910
48BCKDK1.23258372
49MATK1.22637255
50RPS6KA41.22236431
51KIT1.18874861
52ATR1.18725278
53STK391.16696245
54AURKA1.11521229
55MAP3K121.10497918
56STK241.09743746
57PLK21.09439148
58OBSCN1.08986807
59PNCK1.07231254
60PLK41.05052907
61NLK1.05023758
62CDK71.03896381
63PHKG21.02716358
64PHKG11.02716358
65TTK1.01369748
66BRSK10.96986425
67MAPK130.96733590
68GRK10.96726056
69WNK40.95575761
70PDK20.95015336
71MKNK10.94791240
72PINK10.92598327
73DYRK20.92538430
74MAP3K60.92070149
75YES10.90179295
76KDR0.88388459
77IRAK40.88174654
78LIMK10.87128483
79BTK0.86644283
80MAP2K30.85304239
81TAF10.84176846
82OXSR10.82145785
83MAP3K140.81624285
84STK38L0.79564950
85TYK20.79553911
86MUSK0.76331758
87PLK30.75055954
88CCNB10.74025982
89CHEK20.69774066
90TGFBR10.68424750
91CLK10.67929037
92DAPK10.67409842
93ZAP700.64760021
94PIK3CA0.62928322
95LATS10.62123073
96SIK30.61703399
97CAMK10.61566196
98STK30.61001641
99PRKCG0.60934615
100IKBKB0.60523139
101CDK40.58354129
102PRKCE0.57741507
103MINK10.55795864
104PAK30.55694067
105PDK30.54954204
106PDK40.54954204
107CSNK2A20.54927494
108MARK10.54703105
109PIM10.54524731
110BMX0.53181130
111AKT20.52925350
112LYN0.52523796
113STK40.51983521
114CASK0.51832165
115CSNK1E0.49896119
116CSNK2A10.49826226
117CAMKK20.48731745
118BMPR20.48290695
119CDK30.48006446
120FLT30.47915118
121TLK10.47553096
122ERBB30.47428643
123CHEK10.46946702
124BRD40.46361937
125ERBB40.43626787
126MAP3K90.43424465
127TAOK20.43098248
128PKN10.43080982
129ATM0.41980659
130NME10.41841447
131CSNK1D0.41371067
132MAP2K60.40735933
133PASK0.40495991
134ADRBK20.40341770
135TBK10.39992477
136AKT30.39790552
137IKBKE0.39323593
138CDK80.39023463
139CAMK2D0.37604008
140CSNK1A10.36719710
141RPS6KB20.36077566
142RPS6KA50.35590680
143CDK190.35121702
144CAMK2A0.35104401
145ITK0.34796478
146RPS6KB10.34665694
147SYK0.34342043
148FGFR10.34286501
149ABL20.29233522

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.48755780
2Proteasome_Homo sapiens_hsa030503.55109214
3Mismatch repair_Homo sapiens_hsa034303.33786657
4RNA polymerase_Homo sapiens_hsa030202.98049982
5Base excision repair_Homo sapiens_hsa034102.92396486
6Homologous recombination_Homo sapiens_hsa034402.86772107
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.84423729
8Pyrimidine metabolism_Homo sapiens_hsa002402.62502623
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.28264776
10Ribosome_Homo sapiens_hsa030102.26360689
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.20794629
12Nucleotide excision repair_Homo sapiens_hsa034202.19503792
13Spliceosome_Homo sapiens_hsa030402.10168728
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05403715
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.04000263
16Fanconi anemia pathway_Homo sapiens_hsa034602.02077125
17RNA transport_Homo sapiens_hsa030132.01392705
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.96245640
19Non-homologous end-joining_Homo sapiens_hsa034501.93426352
20One carbon pool by folate_Homo sapiens_hsa006701.92880951
21Linoleic acid metabolism_Homo sapiens_hsa005911.84826875
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.79903846
23Cell cycle_Homo sapiens_hsa041101.78019506
24Butanoate metabolism_Homo sapiens_hsa006501.75401540
25Folate biosynthesis_Homo sapiens_hsa007901.75031360
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.74175546
27Vitamin digestion and absorption_Homo sapiens_hsa049771.72251656
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.70845146
29Fatty acid elongation_Homo sapiens_hsa000621.66980516
30Basal transcription factors_Homo sapiens_hsa030221.59620886
31Pyruvate metabolism_Homo sapiens_hsa006201.58931690
32Purine metabolism_Homo sapiens_hsa002301.54270920
33RNA degradation_Homo sapiens_hsa030181.52168566
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.45639477
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.40566266
36Arachidonic acid metabolism_Homo sapiens_hsa005901.28082578
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.27485432
38Fatty acid degradation_Homo sapiens_hsa000711.25246028
39Selenocompound metabolism_Homo sapiens_hsa004501.24468178
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.23845373
41Steroid biosynthesis_Homo sapiens_hsa001001.21826471
42Primary immunodeficiency_Homo sapiens_hsa053401.21735200
43p53 signaling pathway_Homo sapiens_hsa041151.21292339
44Protein export_Homo sapiens_hsa030601.20894728
45Fatty acid metabolism_Homo sapiens_hsa012121.18276889
46Herpes simplex infection_Homo sapiens_hsa051681.17344904
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.16977916
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.13993943
49Tryptophan metabolism_Homo sapiens_hsa003801.11424200
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08137878
51Primary bile acid biosynthesis_Homo sapiens_hsa001201.07540707
52Sulfur relay system_Homo sapiens_hsa041221.06169681
53Intestinal immune network for IgA production_Homo sapiens_hsa046721.04537118
54Allograft rejection_Homo sapiens_hsa053301.03337226
55Sulfur metabolism_Homo sapiens_hsa009201.00029035
56Nitrogen metabolism_Homo sapiens_hsa009100.99574487
57Legionellosis_Homo sapiens_hsa051340.99408275
58Parkinsons disease_Homo sapiens_hsa050120.98931370
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98347265
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.96956617
61Huntingtons disease_Homo sapiens_hsa050160.96922811
62Other glycan degradation_Homo sapiens_hsa005110.96071363
63Caffeine metabolism_Homo sapiens_hsa002320.95431321
64Cardiac muscle contraction_Homo sapiens_hsa042600.93956234
65Pentose phosphate pathway_Homo sapiens_hsa000300.93419715
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92433304
67Retinol metabolism_Homo sapiens_hsa008300.90911504
68Fructose and mannose metabolism_Homo sapiens_hsa000510.90760428
69* Oxidative phosphorylation_Homo sapiens_hsa001900.88831989
70Epstein-Barr virus infection_Homo sapiens_hsa051690.87932504
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.82600407
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78844491
73Phototransduction_Homo sapiens_hsa047440.78409782
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77367281
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.77253547
76Chemical carcinogenesis_Homo sapiens_hsa052040.75896788
77Arginine biosynthesis_Homo sapiens_hsa002200.75130260
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75069581
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72604074
80Biosynthesis of amino acids_Homo sapiens_hsa012300.69917641
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69593955
82Antigen processing and presentation_Homo sapiens_hsa046120.67960867
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66648205
84Fat digestion and absorption_Homo sapiens_hsa049750.65123550
85Hematopoietic cell lineage_Homo sapiens_hsa046400.64718966
86Measles_Homo sapiens_hsa051620.63523171
87Graft-versus-host disease_Homo sapiens_hsa053320.63341376
88Type I diabetes mellitus_Homo sapiens_hsa049400.62926789
89Galactose metabolism_Homo sapiens_hsa000520.62585499
90Oocyte meiosis_Homo sapiens_hsa041140.62284525
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.61436687
92N-Glycan biosynthesis_Homo sapiens_hsa005100.60674315
93Peroxisome_Homo sapiens_hsa041460.60442867
94Tyrosine metabolism_Homo sapiens_hsa003500.58219735
95* Metabolic pathways_Homo sapiens_hsa011000.55567819
96beta-Alanine metabolism_Homo sapiens_hsa004100.55086198
97Autoimmune thyroid disease_Homo sapiens_hsa053200.55047710
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.53844000
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53326387
100mRNA surveillance pathway_Homo sapiens_hsa030150.52422437
101Carbon metabolism_Homo sapiens_hsa012000.50849206
102Histidine metabolism_Homo sapiens_hsa003400.50695423
103Thyroid cancer_Homo sapiens_hsa052160.50577153
104Nicotine addiction_Homo sapiens_hsa050330.50370284
105Systemic lupus erythematosus_Homo sapiens_hsa053220.50030310
106Arginine and proline metabolism_Homo sapiens_hsa003300.49662763
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48790119
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47364797
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43603388
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43205964
111Asthma_Homo sapiens_hsa053100.42353929
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42057940
113Starch and sucrose metabolism_Homo sapiens_hsa005000.41990961
114Ether lipid metabolism_Homo sapiens_hsa005650.41463546
115Vitamin B6 metabolism_Homo sapiens_hsa007500.39654716
116Glutathione metabolism_Homo sapiens_hsa004800.39012070
117Taste transduction_Homo sapiens_hsa047420.38976775
118Shigellosis_Homo sapiens_hsa051310.37482261
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35780526
120Viral carcinogenesis_Homo sapiens_hsa052030.35654399
121Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35159394
122Alzheimers disease_Homo sapiens_hsa050100.34349861
123Propanoate metabolism_Homo sapiens_hsa006400.34122253
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33266891
125Maturity onset diabetes of the young_Homo sapiens_hsa049500.33221382
126Apoptosis_Homo sapiens_hsa042100.32154776
127HTLV-I infection_Homo sapiens_hsa051660.31973367
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31968761
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31837148
130Regulation of autophagy_Homo sapiens_hsa041400.31292804
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30036786
132Lysine degradation_Homo sapiens_hsa003100.29796857
133Collecting duct acid secretion_Homo sapiens_hsa049660.29568159
134Malaria_Homo sapiens_hsa051440.27833117
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27823935
136Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27254044
137Influenza A_Homo sapiens_hsa051640.27015554
138Leishmaniasis_Homo sapiens_hsa051400.26455441
139Phenylalanine metabolism_Homo sapiens_hsa003600.24146590
140Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.20173560
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19899439

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