ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	8.66719316
2	resolution of meiotic recombination intermediates (GO:0000712)	5.81119879
3	platelet dense granule organization (GO:0060155)	4.70955576
4	kinetochore organization (GO:0051383)	4.58963205
5	regulation of hexokinase activity (GO:1903299)	4.55783840
6	regulation of glucokinase activity (GO:0033131)	4.55783840
7	DNA damage response, detection of DNA damage (GO:0042769)	4.31174879
8	protein polyglutamylation (GO:0018095)	4.27489195
9	proline transport (GO:0015824)	4.12156270
10	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.08996143
11	water-soluble vitamin biosynthetic process (GO:0042364)	4.02052080
12	sequestering of actin monomers (GO:0042989)	4.01629360
13	regulation of non-canonical Wnt signaling pathway (GO:2000050)	4.00996123
14	cellular response to cholesterol (GO:0071397)	3.99760357
15	mitotic metaphase plate congression (GO:0007080)	3.88433936
16	ether lipid metabolic process (GO:0046485)	3.83410125
17	metaphase plate congression (GO:0051310)	3.74873628
18	protein K11-linked deubiquitination (GO:0035871)	3.66246757
19	preassembly of GPI anchor in ER membrane (GO:0016254)	3.63770701
20	cellular response to sterol (GO:0036315)	3.57363881
21	alanine transport (GO:0032328)	3.56778001
22	regulation of cilium movement (GO:0003352)	3.56749483
23	ubiquinone metabolic process (GO:0006743)	3.53976981
24	DNA double-strand break processing (GO:0000729)	3.49920865
25	intraciliary transport (GO:0042073)	3.45710335
26	regulation of memory T cell differentiation (GO:0043380)	3.45548357
27	ventricular cardiac muscle cell development (GO:0055015)	3.44597307
28	purine nucleobase biosynthetic process (GO:0009113)	3.42956748
29	replication fork processing (GO:0031297)	3.42552139
30	kinetochore assembly (GO:0051382)	3.40045324
31	protein neddylation (GO:0045116)	3.37291357
32	cell proliferation in forebrain (GO:0021846)	3.36135622
33	meiotic chromosome segregation (GO:0045132)	3.33354943
34	DNA topological change (GO:0006265)	3.29923249
35	DNA deamination (GO:0045006)	3.27069601
36	nucleobase biosynthetic process (GO:0046112)	3.26002725
37	protein K6-linked ubiquitination (GO:0085020)	3.22923939
38	DNA ligation (GO:0006266)	3.19971809
39	isoprenoid biosynthetic process (GO:0008299)	3.19247932
40	glycerol ether metabolic process (GO:0006662)	3.14284498
41	somite development (GO:0061053)	3.13737586
42	nucleotide-excision repair, DNA gap filling (GO:0006297)	3.12829138
43	striatum development (GO:0021756)	3.08133077
44	male meiosis (GO:0007140)	3.07667576
45	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.06834261
46	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.06834261
47	NADH dehydrogenase complex assembly (GO:0010257)	3.06834261
48	histone H2A ubiquitination (GO:0033522)	3.02872828
49	maturation of 5.8S rRNA (GO:0000460)	3.01036756
50	negative regulation of RNA splicing (GO:0033119)	2.99233326
51	positive regulation of T cell differentiation in thymus (GO:0033089)	2.97451394
52	ether metabolic process (GO:0018904)	2.92067131
53	histone H2A acetylation (GO:0043968)	2.90908458
54	behavioral response to nicotine (GO:0035095)	2.88419080
55	response to cholesterol (GO:0070723)	2.86983214
56	thalamus development (GO:0021794)	2.85982798
57	histone exchange (GO:0043486)	2.85708664
58	C4-dicarboxylate transport (GO:0015740)	2.84123122
59	chromatin remodeling at centromere (GO:0031055)	2.83831846
60	axoneme assembly (GO:0035082)	2.83766862
61	pseudouridine synthesis (GO:0001522)	2.81027130
62	heterochromatin organization (GO:0070828)	2.79955148
63	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.79624548
64	histone H2A monoubiquitination (GO:0035518)	2.79119901
65	DNA catabolic process, exonucleolytic (GO:0000738)	2.78191674
66	establishment of chromosome localization (GO:0051303)	2.77765835
67	recombinational repair (GO:0000725)	2.77636195
68	negative regulation of mRNA processing (GO:0050686)	2.77120319
69	lactate metabolic process (GO:0006089)	2.77014208
70	negative regulation of astrocyte differentiation (GO:0048712)	2.77004773
71	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	2.76748945
72	inner ear receptor stereocilium organization (GO:0060122)	2.76620367
73	synapsis (GO:0007129)	2.75342954
74	cell wall macromolecule catabolic process (GO:0016998)	2.73854375
75	cholesterol biosynthetic process (GO:0006695)	2.73784500
76	response to sterol (GO:0036314)	2.72200075
77	double-strand break repair via homologous recombination (GO:0000724)	2.68800462
78	ubiquinone biosynthetic process (GO:0006744)	2.67914427
79	positive regulation of T cell cytokine production (GO:0002726)	2.67231676
80	mismatch repair (GO:0006298)	2.65723327
81	retinal cone cell development (GO:0046549)	2.61356586
82	left/right axis specification (GO:0070986)	2.60522220
83	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.59961574
84	magnesium ion transport (GO:0015693)	2.58879699
85	lateral ventricle development (GO:0021670)	2.58076351
86	rRNA modification (GO:0000154)	2.57182495
87	negative regulation of alpha-beta T cell differentiation (GO:0046639)	2.56119270
88	spliceosomal snRNP assembly (GO:0000387)	2.55624070
89	cell migration involved in gastrulation (GO:0042074)	2.53934240
90	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.53781945
91	lymphangiogenesis (GO:0001946)	2.53223139
92	respiratory chain complex IV assembly (GO:0008535)	2.53031784
93	aldehyde catabolic process (GO:0046185)	2.49152751
94	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.49084642
95	mitochondrial respiratory chain complex assembly (GO:0033108)	2.48690549
96	DNA strand elongation involved in DNA replication (GO:0006271)	2.47573405
97	retinal ganglion cell axon guidance (GO:0031290)	2.47502220
98	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	2.46799481
99	response to hydroperoxide (GO:0033194)	2.46479179
100	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.45993553

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.56244758
2	VDR_22108803_ChIP-Seq_LS180_Human	3.29797501
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.25571269
4	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.15587914
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.13283457
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.10400479
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.04943398
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.92482246
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.74908268
10	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.60144895
11	EWS_26573619_Chip-Seq_HEK293_Human	2.57287529
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.57280814
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.52314018
14	MYC_18940864_ChIP-ChIP_HL60_Human	2.50794447
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.35141679
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.25815800
17	P300_19829295_ChIP-Seq_ESCs_Human	2.15680640
18	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.13646426
19	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.07320474
20	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.06568474
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.03820315
22	ELK1_19687146_ChIP-ChIP_HELA_Human	2.00812387
23	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.00786827
24	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.98849825
25	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.83291227
26	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.80228124
27	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.78291664
28	FOXP3_21729870_ChIP-Seq_TREG_Human	1.77746083
29	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.71212289
30	FUS_26573619_Chip-Seq_HEK293_Human	1.65870761
31	CBP_20019798_ChIP-Seq_JUKART_Human	1.63299937
32	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.63299937
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.53662201
34	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.53350156
35	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.52141373
36	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.52131744
37	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.49072372
38	BCAT_22108803_ChIP-Seq_LS180_Human	1.46365853
39	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.44089710
40	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.43823507
41	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.43823507
42	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.41930511
43	VDR_23849224_ChIP-Seq_CD4+_Human	1.39308702
44	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.38898022
45	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.38441932
46	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.37846194
47	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.37712046
48	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.37152984
49	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.37075655
50	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.36722989
51	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.36579415
52	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.35939523
53	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.35916894
54	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.32116087
55	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.31196939
56	ER_23166858_ChIP-Seq_MCF-7_Human	1.29136776
57	GBX2_23144817_ChIP-Seq_PC3_Human	1.25864625
58	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.25797916
59	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.25758215
60	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.25626018
61	HTT_18923047_ChIP-ChIP_STHdh_Human	1.25597518
62	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24919083
63	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.24412419
64	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.22024935
65	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.21208357
66	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.20468118
67	TCF4_22108803_ChIP-Seq_LS180_Human	1.20227390
68	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.18017032
69	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.16881219
70	NCOR_22424771_ChIP-Seq_293T_Human	1.15913643
71	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.15797397
72	SMAD4_21799915_ChIP-Seq_A2780_Human	1.15507728
73	TP53_22573176_ChIP-Seq_HFKS_Human	1.14549405
74	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.14348784
75	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.12665685
76	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.10767959
77	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.10149494
78	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.10149494
79	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.06857906
80	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.05949573
81	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04189677
82	TTF2_22483619_ChIP-Seq_HELA_Human	1.04168922
83	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.03553873
84	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.03170684
85	EZH2_22144423_ChIP-Seq_EOC_Human	1.02551852
86	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.01823621
87	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.00819251
88	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.00806320
89	NANOG_19829295_ChIP-Seq_ESCs_Human	1.00292715
90	SOX2_19829295_ChIP-Seq_ESCs_Human	1.00292715
91	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.99003145
92	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.98993652
93	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.98526720
94	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.98213821
95	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.97669198
96	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.96002980
97	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.95588001
98	STAT3_23295773_ChIP-Seq_U87_Human	0.93772418
99	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.92929111
100	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.92804703

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	5.07834335
2	MP0006292_abnormal_olfactory_placode	3.76186952
3	MP0008877_abnormal_DNA_methylation	3.42131776
4	MP0002102_abnormal_ear_morphology	2.89543288
5	MP0008789_abnormal_olfactory_epithelium	2.81571692
6	MP0010094_abnormal_chromosome_stability	2.70671602
7	MP0009697_abnormal_copulation	2.67608558
8	MP0000372_irregular_coat_pigmentation	2.29359660
9	MP0006072_abnormal_retinal_apoptosis	2.25061050
10	MP0008058_abnormal_DNA_repair	2.17531985
11	MP0005647_abnormal_sex_gland	2.07889955
12	MP0008932_abnormal_embryonic_tissue	2.07595563
13	MP0001529_abnormal_vocalization	2.05573317
14	MP0009053_abnormal_anal_canal	2.02925628
15	MP0003880_abnormal_central_pattern	2.02588626
16	MP0002282_abnormal_trachea_morphology	2.01037419
17	MP0006054_spinal_hemorrhage	1.91662088
18	MP0002653_abnormal_ependyma_morphology	1.91349375
19	MP0005171_absent_coat_pigmentation	1.87277456
20	MP0003122_maternal_imprinting	1.86622982
21	MP0005394_taste/olfaction_phenotype	1.85903007
22	MP0005499_abnormal_olfactory_system	1.85903007
23	MP0002254_reproductive_system_inflammat	1.84774229
24	MP0010368_abnormal_lymphatic_system	1.81068009
25	MP0001485_abnormal_pinna_reflex	1.79753115
26	MP0002127_abnormal_cardiovascular_syste	1.74540790
27	MP0002938_white_spotting	1.72799221
28	MP0003567_abnormal_fetal_cardiomyocyte	1.68424210
29	MP0003121_genomic_imprinting	1.65505834
30	MP0008775_abnormal_heart_ventricle	1.50017276
31	MP0005253_abnormal_eye_physiology	1.49581158
32	MP0004133_heterotaxia	1.49386004
33	MP0004885_abnormal_endolymph	1.49123667
34	MP0003195_calcinosis	1.46618977
35	MP0001984_abnormal_olfaction	1.45972281
36	MP0002837_dystrophic_cardiac_calcinosis	1.45854404
37	MP0003718_maternal_effect	1.41807815
38	MP0005551_abnormal_eye_electrophysiolog	1.40099111
39	MP0003693_abnormal_embryo_hatching	1.38929879
40	MP0003787_abnormal_imprinting	1.37936568
41	MP0003136_yellow_coat_color	1.35610342
42	MP0003123_paternal_imprinting	1.31063046
43	MP0001293_anophthalmia	1.29702208
44	MP0003890_abnormal_embryonic-extraembry	1.29510300
45	MP0001727_abnormal_embryo_implantation	1.28905692
46	MP0000049_abnormal_middle_ear	1.24420776
47	MP0003137_abnormal_impulse_conducting	1.17724994
48	MP0001119_abnormal_female_reproductive	1.11652279
49	MP0004381_abnormal_hair_follicle	1.10580885
50	MP0005084_abnormal_gallbladder_morpholo	1.10233860
51	MP0003221_abnormal_cardiomyocyte_apopto	1.09758053
52	MP0002233_abnormal_nose_morphology	1.09617696
53	MP0003111_abnormal_nucleus_morphology	1.08761266
54	MP0008007_abnormal_cellular_replicative	1.06540017
55	MP0005083_abnormal_biliary_tract	1.04085857
56	MP0005195_abnormal_posterior_eye	1.03833584
57	MP0005646_abnormal_pituitary_gland	1.03461573
58	MP0004782_abnormal_surfactant_physiolog	1.01598943
59	MP0001929_abnormal_gametogenesis	1.01016412
60	MP0003938_abnormal_ear_development	1.00157780
61	MP0006276_abnormal_autonomic_nervous	1.00017731
62	MP0003937_abnormal_limbs/digits/tail_de	0.99773520
63	MP0002210_abnormal_sex_determination	0.99148110
64	MP0002090_abnormal_vision	0.98048869
65	MP0001963_abnormal_hearing_physiology	0.97956173
66	MP0001177_atelectasis	0.97884862
67	MP0002752_abnormal_somatic_nervous	0.96065840
68	MP0008872_abnormal_physiological_respon	0.95780155
69	MP0004957_abnormal_blastocyst_morpholog	0.95440481
70	MP0005075_abnormal_melanosome_morpholog	0.94688822
71	MP0004215_abnormal_myocardial_fiber	0.92714291
72	MP0000026_abnormal_inner_ear	0.90510099
73	MP0004084_abnormal_cardiac_muscle	0.88701134
74	MP0003119_abnormal_digestive_system	0.88642801
75	MP0003942_abnormal_urinary_system	0.88264415
76	MP0006035_abnormal_mitochondrial_morpho	0.88028884
77	MP0000653_abnormal_sex_gland	0.87603613
78	MP0005395_other_phenotype	0.85024605
79	MP0000955_abnormal_spinal_cord	0.83981218
80	MP0001286_abnormal_eye_development	0.83819558
81	MP0003077_abnormal_cell_cycle	0.83565932
82	MP0000631_abnormal_neuroendocrine_gland	0.83382119
83	MP0002638_abnormal_pupillary_reflex	0.82519042
84	MP0001145_abnormal_male_reproductive	0.80866476
85	MP0002160_abnormal_reproductive_system	0.80658147
86	MP0009745_abnormal_behavioral_response	0.80345599
87	MP0002932_abnormal_joint_morphology	0.79283699
88	MP0002572_abnormal_emotion/affect_behav	0.75671055
89	MP0003755_abnormal_palate_morphology	0.74508605
90	MP0000778_abnormal_nervous_system	0.73601011
91	MP0002272_abnormal_nervous_system	0.72748454
92	MP0002557_abnormal_social/conspecific_i	0.71646499
93	MP0001697_abnormal_embryo_size	0.71594406
94	MP0001486_abnormal_startle_reflex	0.70290014
95	MP0002084_abnormal_developmental_patter	0.69154975
96	MP0003385_abnormal_body_wall	0.68433444
97	MP0003935_abnormal_craniofacial_develop	0.67922587
98	MP0009703_decreased_birth_body	0.67124159
99	MP0002184_abnormal_innervation	0.65350307
100	MP0001544_abnormal_cardiovascular_syste	0.64440419

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Methylmalonic acidemia (HP:0002912)	3.98817158
2	Sclerocornea (HP:0000647)	3.29062253
3	Abnormality of alanine metabolism (HP:0010916)	3.28803820
4	Hyperalaninemia (HP:0003348)	3.28803820
5	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.28803820
6	Hypoplasia of the fovea (HP:0007750)	3.21727700
7	Aplasia/Hypoplasia of the fovea (HP:0008060)	3.21727700
8	Hyperglycinuria (HP:0003108)	3.06989098
9	Meckel diverticulum (HP:0002245)	2.93454012
10	Abnormality of the ileum (HP:0001549)	2.88142702
11	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.84356069
12	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.84246268
13	Absent/shortened dynein arms (HP:0200106)	2.84246268
14	Nephronophthisis (HP:0000090)	2.82430475
15	True hermaphroditism (HP:0010459)	2.78619584
16	Pancreatic fibrosis (HP:0100732)	2.69778313
17	Carpal bone hypoplasia (HP:0001498)	2.69683916
18	Abnormality of the fovea (HP:0000493)	2.63192007
19	Pancreatic cysts (HP:0001737)	2.58369061
20	Hyperglycinemia (HP:0002154)	2.56692174
21	Hypothermia (HP:0002045)	2.55499219
22	Abnormality of midbrain morphology (HP:0002418)	2.54064203
23	Molar tooth sign on MRI (HP:0002419)	2.54064203
24	Acute necrotizing encephalopathy (HP:0006965)	2.52675929
25	Methylmalonic aciduria (HP:0012120)	2.52305368
26	Abnormality of glycine metabolism (HP:0010895)	2.47423301
27	Abnormality of serine family amino acid metabolism (HP:0010894)	2.47423301
28	Atonic seizures (HP:0010819)	2.47302870
29	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.45440507
30	Severe combined immunodeficiency (HP:0004430)	2.40115243
31	Abnormality of the vertebral endplates (HP:0005106)	2.38716177
32	Abnormality of the pancreatic islet cells (HP:0006476)	2.36388199
33	Abnormality of endocrine pancreas physiology (HP:0012093)	2.36388199
34	Abnormality of the 4th metacarpal (HP:0010012)	2.33830272
35	Poor head control (HP:0002421)	2.33489838
36	Stenosis of the external auditory canal (HP:0000402)	2.29117542
37	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.27519162
38	Increased CSF lactate (HP:0002490)	2.26261445
39	Acute encephalopathy (HP:0006846)	2.25086336
40	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.23581323
41	High anterior hairline (HP:0009890)	2.22369369
42	Mitochondrial inheritance (HP:0001427)	2.22207206
43	Short 4th metacarpal (HP:0010044)	2.21955163
44	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.21955163
45	Decreased central vision (HP:0007663)	2.20367242
46	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.20280695
47	Pigmentary retinal degeneration (HP:0001146)	2.19129416
48	Adactyly (HP:0009776)	2.18661388
49	Thyroiditis (HP:0100646)	2.17202794
50	Increased hepatocellular lipid droplets (HP:0006565)	2.16859245
51	Abnormality of vitamin B metabolism (HP:0004340)	2.14381011
52	Increased serum pyruvate (HP:0003542)	2.13330330
53	Pendular nystagmus (HP:0012043)	2.12367741
54	Abnormality of DNA repair (HP:0003254)	2.12334855
55	Preaxial hand polydactyly (HP:0001177)	2.11147985
56	Abnormality of the preputium (HP:0100587)	2.10309376
57	Abnormal rod and cone electroretinograms (HP:0008323)	2.09766579
58	Postaxial foot polydactyly (HP:0001830)	2.06826135
59	Lipid accumulation in hepatocytes (HP:0006561)	2.01676994
60	Abnormal ciliary motility (HP:0012262)	1.99105410
61	Progressive macrocephaly (HP:0004481)	1.98440225
62	Abdominal situs inversus (HP:0003363)	1.97610044
63	Abnormality of abdominal situs (HP:0011620)	1.97610044
64	Congenital stationary night blindness (HP:0007642)	1.96082409
65	Abnormality of the renal medulla (HP:0100957)	1.96075462
66	Septo-optic dysplasia (HP:0100842)	1.94006197
67	Abnormality of the carotid arteries (HP:0005344)	1.93473595
68	Congenital hepatic fibrosis (HP:0002612)	1.92857883
69	Anomalous pulmonary venous return (HP:0010772)	1.90595939
70	Diastasis recti (HP:0001540)	1.90210974
71	Aplasia/hypoplasia of the humerus (HP:0006507)	1.89840988
72	Abnormality of chromosome stability (HP:0003220)	1.89614249
73	Abnormal mitochondria in muscle tissue (HP:0008316)	1.88989499
74	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	1.88393511
75	Abnormality of the middle phalanges of the toes (HP:0010183)	1.87636280
76	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.87447962
77	Absent epiphyses (HP:0010577)	1.87447962
78	Type I transferrin isoform profile (HP:0003642)	1.87064592
79	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.87049108
80	Irregular vertebral endplates (HP:0003301)	1.86836157
81	Abnormality of serum amino acid levels (HP:0003112)	1.86739787
82	Postaxial hand polydactyly (HP:0001162)	1.86726216
83	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.83888811
84	Ectopic kidney (HP:0000086)	1.83873923
85	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.83462529
86	Medial flaring of the eyebrow (HP:0010747)	1.83292409
87	Abolished electroretinogram (ERG) (HP:0000550)	1.83253347
88	Aplasia/Hypoplasia of the macula (HP:0008059)	1.81426149
89	Increased serum lactate (HP:0002151)	1.80868293
90	Abnormal respiratory epithelium morphology (HP:0012253)	1.80713487
91	Abnormal respiratory motile cilium morphology (HP:0005938)	1.80713487
92	Hepatocellular necrosis (HP:0001404)	1.80463114
93	Combined immunodeficiency (HP:0005387)	1.77788726
94	Astigmatism (HP:0000483)	1.77532953
95	Rib fusion (HP:0000902)	1.77260102
96	Asplenia (HP:0001746)	1.77163772
97	Renal cortical cysts (HP:0000803)	1.77162734
98	Anal atresia (HP:0002023)	1.77030685
99	Clubbing of toes (HP:0100760)	1.76683677
100	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.76396134

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	5.31832868
2	BUB1	4.50135893
3	PRKD3	3.74536357
4	WNK3	3.64645110
5	MAPK13	3.39999022
6	MKNK1	3.07108817
7	NEK9	2.89027228
8	VRK2	2.44250906
9	IRAK1	2.29681197
10	IRAK2	2.26244604
11	BCR	2.15360273
12	TGFBR2	1.99481484
13	MKNK2	1.91748721
14	MAP3K10	1.69650349
15	CSNK1G1	1.60794026
16	PLK3	1.58473516
17	PLK4	1.55668766
18	FRK	1.54401471
19	GRK1	1.48044981
20	ATR	1.36339387
21	CSNK1G2	1.30140943
22	BRD4	1.28420118
23	STK16	1.28100578
24	TAOK1	1.27248932
25	KDR	1.22343413
26	ADRBK2	1.21756267
27	WEE1	1.21213419
28	CSNK1G3	1.20971452
29	STK10	1.19776922
30	PLK1	1.17825613
31	TIE1	1.15931185
32	EIF2AK3	1.14592325
33	GRK7	1.14386671
34	MAP3K4	1.08848798
35	CSNK1A1L	1.03242214
36	TNK2	0.97914856
37	BMPR1B	0.97547758
38	UHMK1	0.96181575
39	VRK1	0.93743487
40	TGFBR1	0.93333894
41	INSRR	0.91998636
42	EIF2AK2	0.90817410
43	SRPK1	0.90389201
44	PKN1	0.89992354
45	WNK4	0.88740673
46	ERBB3	0.83279805
47	AURKB	0.82798178
48	MST4	0.81886923
49	NUAK1	0.80234676
50	OXSR1	0.77634561
51	STK39	0.76913187
52	EPHA4	0.75909827
53	CDK19	0.73788485
54	STK38L	0.72376461
55	PLK2	0.71327251
56	TNIK	0.70919879
57	PNCK	0.70290409
58	MAP2K7	0.67538247
59	TXK	0.66223022
60	DYRK2	0.65671534
61	ZAK	0.65216595
62	PBK	0.64764811
63	NTRK2	0.64495015
64	PRKCI	0.64171346
65	TLK1	0.60714438
66	PINK1	0.60249027
67	ATM	0.59688704
68	MINK1	0.56030701
69	PRKCE	0.54414070
70	TAF1	0.53859683
71	EPHB2	0.53781360
72	CLK1	0.52962392
73	ADRBK1	0.51732862
74	GRK5	0.51371415
75	CSNK1D	0.48401638
76	RPS6KA5	0.45902990
77	PRKCG	0.44403791
78	PRKDC	0.44355479
79	PAK6	0.43661657
80	CASK	0.41923332
81	TSSK6	0.41780757
82	CDK7	0.40808560
83	RPS6KA4	0.38773168
84	BCKDK	0.38613346
85	PAK3	0.38534558
86	DYRK1A	0.38295798
87	PDK2	0.38249725
88	CDC7	0.37679030
89	CDK9	0.35935544
90	CSNK2A1	0.35516210
91	CDK1	0.34085377
92	DYRK1B	0.34051965
93	KIT	0.33965686
94	CSNK1A1	0.32480551
95	PTK2B	0.31005261
96	PASK	0.30514756
97	TAOK3	0.29979556
98	OBSCN	0.28437348
99	FGFR2	0.28071475
100	MAPKAPK5	0.26932827

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.90791903
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.71642831
3	Non-homologous end-joining_Homo sapiens_hsa03450	2.69857419
4	Propanoate metabolism_Homo sapiens_hsa00640	2.66785168
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.55172795
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.51406753
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.43841618
8	DNA replication_Homo sapiens_hsa03030	2.33200713
9	Proteasome_Homo sapiens_hsa03050	2.28303515
10	Protein export_Homo sapiens_hsa03060	2.18282594
11	RNA polymerase_Homo sapiens_hsa03020	2.15742086
12	Oxidative phosphorylation_Homo sapiens_hsa00190	2.15596046
13	Mismatch repair_Homo sapiens_hsa03430	2.13116032
14	Nucleotide excision repair_Homo sapiens_hsa03420	2.10427055
15	Homologous recombination_Homo sapiens_hsa03440	2.03651487
16	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.95162237
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.94413849
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.90060014
19	RNA transport_Homo sapiens_hsa03013	1.82914469
20	RNA degradation_Homo sapiens_hsa03018	1.69610314
21	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.69270406
22	Butanoate metabolism_Homo sapiens_hsa00650	1.64616746
23	Basal transcription factors_Homo sapiens_hsa03022	1.64484193
24	Parkinsons disease_Homo sapiens_hsa05012	1.56730468
25	Spliceosome_Homo sapiens_hsa03040	1.47428585
26	Glutathione metabolism_Homo sapiens_hsa00480	1.46371441
27	Base excision repair_Homo sapiens_hsa03410	1.41178208
28	Taste transduction_Homo sapiens_hsa04742	1.28850171
29	Pyruvate metabolism_Homo sapiens_hsa00620	1.27105060
30	Purine metabolism_Homo sapiens_hsa00230	1.23164976
31	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.20588580
32	Pyrimidine metabolism_Homo sapiens_hsa00240	1.20103117
33	Steroid biosynthesis_Homo sapiens_hsa00100	1.19562419
34	Peroxisome_Homo sapiens_hsa04146	1.19438859
35	Nicotine addiction_Homo sapiens_hsa05033	1.19010684
36	Cell cycle_Homo sapiens_hsa04110	1.16796615
37	Huntingtons disease_Homo sapiens_hsa05016	1.16546264
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.16213148
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.14144957
40	Olfactory transduction_Homo sapiens_hsa04740	1.13538542
41	beta-Alanine metabolism_Homo sapiens_hsa00410	1.08461363
42	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.08235999
43	Phototransduction_Homo sapiens_hsa04744	1.06113665
44	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.05502948
45	Linoleic acid metabolism_Homo sapiens_hsa00591	1.02563321
46	Retinol metabolism_Homo sapiens_hsa00830	0.98178247
47	Alzheimers disease_Homo sapiens_hsa05010	0.97282329
48	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.96767266
49	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.95796488
50	Oocyte meiosis_Homo sapiens_hsa04114	0.95385002
51	Nitrogen metabolism_Homo sapiens_hsa00910	0.95355473
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.94303495
53	Ribosome_Homo sapiens_hsa03010	0.92397141
54	p53 signaling pathway_Homo sapiens_hsa04115	0.81184388
55	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.81099044
56	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.78402243
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.78259028
58	Arginine and proline metabolism_Homo sapiens_hsa00330	0.76091602
59	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.75474416
60	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.75133719
61	Caffeine metabolism_Homo sapiens_hsa00232	0.74742242
62	One carbon pool by folate_Homo sapiens_hsa00670	0.73969338
63	Glycerolipid metabolism_Homo sapiens_hsa00561	0.72480230
64	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.69225802
65	Circadian rhythm_Homo sapiens_hsa04710	0.68229371
66	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.67541156
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.65458888
68	Tyrosine metabolism_Homo sapiens_hsa00350	0.63763371
69	Fatty acid elongation_Homo sapiens_hsa00062	0.63455841
70	Metabolic pathways_Homo sapiens_hsa01100	0.62327238
71	Fatty acid degradation_Homo sapiens_hsa00071	0.61864736
72	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.61447942
73	Ether lipid metabolism_Homo sapiens_hsa00565	0.60646147
74	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.60153581
75	Cardiac muscle contraction_Homo sapiens_hsa04260	0.58154363
76	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.57912125
77	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.54262458
78	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.53062032
79	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.52782452
80	Lysine degradation_Homo sapiens_hsa00310	0.51825931
81	Primary immunodeficiency_Homo sapiens_hsa05340	0.49703294
82	Fat digestion and absorption_Homo sapiens_hsa04975	0.47821722
83	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.46912765
84	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.46437847
85	Selenocompound metabolism_Homo sapiens_hsa00450	0.44502845
86	Basal cell carcinoma_Homo sapiens_hsa05217	0.44269186
87	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.44162879
88	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.43838275
89	Renin-angiotensin system_Homo sapiens_hsa04614	0.43165503
90	Tryptophan metabolism_Homo sapiens_hsa00380	0.42883229
91	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.41970545
92	Hippo signaling pathway_Homo sapiens_hsa04390	0.38901558
93	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.38165588
94	Fatty acid metabolism_Homo sapiens_hsa01212	0.36826887
95	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.34948391
96	Carbon metabolism_Homo sapiens_hsa01200	0.33895904
97	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.33785680
98	Morphine addiction_Homo sapiens_hsa05032	0.28305218
99	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.26749927
100	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.25107617

COX11P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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