COX15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates two transcript variants diverging in the 3' region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine metabolic process (GO:0006553)6.03226656
2lysine catabolic process (GO:0006554)6.03226656
3oxaloacetate metabolic process (GO:0006107)4.85518130
4double-strand break repair via nonhomologous end joining (GO:0006303)4.75638477
5non-recombinational repair (GO:0000726)4.75638477
62-oxoglutarate metabolic process (GO:0006103)4.67367134
7valine metabolic process (GO:0006573)4.66098747
8aspartate family amino acid catabolic process (GO:0009068)4.44252747
9L-phenylalanine metabolic process (GO:0006558)4.42401875
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.42401875
11fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.36888783
12cysteine metabolic process (GO:0006534)4.36706561
13tricarboxylic acid cycle (GO:0006099)4.36315881
14cullin deneddylation (GO:0010388)4.36287723
15alpha-linolenic acid metabolic process (GO:0036109)4.34723490
16tricarboxylic acid metabolic process (GO:0072350)4.34014963
17glyoxylate metabolic process (GO:0046487)4.25897636
18L-phenylalanine catabolic process (GO:0006559)4.20079444
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.20079444
20lactate metabolic process (GO:0006089)4.19635590
21cellular ketone body metabolic process (GO:0046950)4.17589211
22kynurenine metabolic process (GO:0070189)4.13605399
23NADH metabolic process (GO:0006734)4.12169034
24DNA double-strand break processing (GO:0000729)4.07343347
25folic acid-containing compound biosynthetic process (GO:0009396)4.03717637
26COPI coating of Golgi vesicle (GO:0048205)4.00649559
27Golgi transport vesicle coating (GO:0048200)4.00649559
28triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.95112999
29aromatic amino acid family catabolic process (GO:0009074)3.92695371
30protein deneddylation (GO:0000338)3.92274135
31transcription from mitochondrial promoter (GO:0006390)3.87845975
32glycine metabolic process (GO:0006544)3.86044995
33fatty acid beta-oxidation (GO:0006635)3.83776548
34cellular modified amino acid catabolic process (GO:0042219)3.80540962
35branched-chain amino acid metabolic process (GO:0009081)3.75553270
36* respiratory chain complex IV assembly (GO:0008535)3.69293184
37indole-containing compound catabolic process (GO:0042436)3.67775234
38indolalkylamine catabolic process (GO:0046218)3.67775234
39tryptophan catabolic process (GO:0006569)3.67775234
40maturation of 5.8S rRNA (GO:0000460)3.67451373
41branched-chain amino acid catabolic process (GO:0009083)3.67204354
42establishment of integrated proviral latency (GO:0075713)3.64853210
43amino-acid betaine metabolic process (GO:0006577)3.62982970
44sulfur amino acid catabolic process (GO:0000098)3.62747641
45serine family amino acid metabolic process (GO:0009069)3.61853961
46ketone body metabolic process (GO:1902224)3.58248166
47* cytochrome complex assembly (GO:0017004)3.57778711
48fatty acid oxidation (GO:0019395)3.57487762
49ribosome assembly (GO:0042255)3.57128235
50intestinal cholesterol absorption (GO:0030299)3.56996039
51regulation of mitotic spindle checkpoint (GO:1903504)3.53576384
52regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.53576384
53succinate metabolic process (GO:0006105)3.51986712
54lipid oxidation (GO:0034440)3.48336551
55mitochondrial DNA replication (GO:0006264)3.47908024
56serine family amino acid biosynthetic process (GO:0009070)3.47850098
57tryptophan metabolic process (GO:0006568)3.46840561
58pentose-phosphate shunt (GO:0006098)3.44935219
59positive regulation of mitotic sister chromatid separation (GO:1901970)3.44026569
60positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.44026569
61positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.44026569
62short-chain fatty acid metabolic process (GO:0046459)3.43167812
63drug transmembrane transport (GO:0006855)3.38916753
64regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.38689475
65acetyl-CoA metabolic process (GO:0006084)3.38058603
66homocysteine metabolic process (GO:0050667)3.38000709
67fatty acid catabolic process (GO:0009062)3.37682639
68urea metabolic process (GO:0019627)3.36920795
69urea cycle (GO:0000050)3.36920795
70urate metabolic process (GO:0046415)3.35596899
71alpha-amino acid catabolic process (GO:1901606)3.34939176
72establishment of protein localization to mitochondrial membrane (GO:0090151)3.31284362
73oxidative phosphorylation (GO:0006119)3.27572304
74DNA ligation (GO:0006266)3.26161270
75bile acid biosynthetic process (GO:0006699)3.24955368
76mitochondrial RNA metabolic process (GO:0000959)3.24634092
77NADPH regeneration (GO:0006740)3.24064566
78serine family amino acid catabolic process (GO:0009071)3.23632236
79cellular amino acid catabolic process (GO:0009063)3.23036475
80carnitine metabolic process (GO:0009437)3.22279356
81protein complex biogenesis (GO:0070271)3.18644906
82peptidyl-histidine modification (GO:0018202)3.17923965
83purine nucleobase biosynthetic process (GO:0009113)3.17354384
84mitochondrial respiratory chain complex assembly (GO:0033108)3.15537919
85somatic diversification of immune receptors via somatic mutation (GO:0002566)3.15311159
86somatic hypermutation of immunoglobulin genes (GO:0016446)3.15311159
87DNA catabolic process, exonucleolytic (GO:0000738)3.14376160
88glutamate metabolic process (GO:0006536)3.13639814
89dicarboxylic acid biosynthetic process (GO:0043650)3.13355070
90carnitine shuttle (GO:0006853)3.12483098
91regulation of triglyceride catabolic process (GO:0010896)3.11710668
92somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.11242103
93somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.11242103
94isotype switching (GO:0045190)3.11242103
95monocarboxylic acid catabolic process (GO:0072329)3.10322607
96rRNA modification (GO:0000154)3.09349073
97fatty acid transmembrane transport (GO:1902001)3.09339869
98ethanol oxidation (GO:0006069)3.09119778
99regulation of acyl-CoA biosynthetic process (GO:0050812)3.07356483
100regulation of cholesterol homeostasis (GO:2000188)3.07292191
1014-hydroxyproline metabolic process (GO:0019471)3.06819478
102regulation of mitochondrial translation (GO:0070129)3.06205607
103pteridine-containing compound biosynthetic process (GO:0042559)3.05594122
104drug transport (GO:0015893)3.03716687
105dicarboxylic acid metabolic process (GO:0043648)3.03154590
106plasma lipoprotein particle clearance (GO:0034381)3.01579776
107tRNA aminoacylation (GO:0043039)3.01119389
108amino acid activation (GO:0043038)3.01119389
109intestinal absorption (GO:0050892)2.99955072
110organic acid catabolic process (GO:0016054)2.99890053
111carboxylic acid catabolic process (GO:0046395)2.99890053
112nitrogen cycle metabolic process (GO:0071941)2.99839652
113regulation of fatty acid beta-oxidation (GO:0031998)2.98799748
114high-density lipoprotein particle remodeling (GO:0034375)2.98172171
115one-carbon metabolic process (GO:0006730)2.97290209
116negative regulation of DNA-dependent DNA replication (GO:2000104)2.96857472
117nucleobase biosynthetic process (GO:0046112)2.96710761
118tRNA aminoacylation for protein translation (GO:0006418)2.96569444
119regulation of cofactor metabolic process (GO:0051193)2.96154807
120regulation of coenzyme metabolic process (GO:0051196)2.96154807
121protein K6-linked ubiquitination (GO:0085020)2.95889419
122fatty acid homeostasis (GO:0055089)2.95383761
123tetrahydrofolate metabolic process (GO:0046653)2.95358350
124regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.94297132
125pseudouridine synthesis (GO:0001522)2.94172201
126proteasome assembly (GO:0043248)2.93163087
127negative regulation of fibrinolysis (GO:0051918)2.91870526
128positive regulation of fatty acid beta-oxidation (GO:0032000)2.90519497
129negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.89205180
130folic acid metabolic process (GO:0046655)2.89034603
131water-soluble vitamin biosynthetic process (GO:0042364)2.88777677
132mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.88109393
133mitotic sister chromatid cohesion (GO:0007064)2.87588695
134positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.87448721
135aspartate family amino acid metabolic process (GO:0009066)2.87050592
136regulation of fatty acid oxidation (GO:0046320)2.86426317
137aromatic amino acid family metabolic process (GO:0009072)2.85905511
138acylglycerol homeostasis (GO:0055090)2.85366643
139triglyceride homeostasis (GO:0070328)2.85366643
140negative regulation of fatty acid biosynthetic process (GO:0045717)2.84709150
141antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.84509197
142antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.84509197
143histone H2A acetylation (GO:0043968)2.84146228
144AMP metabolic process (GO:0046033)2.82610086
145IMP biosynthetic process (GO:0006188)2.81997298
146purine nucleotide salvage (GO:0032261)2.81962660
147rRNA methylation (GO:0031167)2.81961801
148replication fork processing (GO:0031297)2.81466955
149regulation of hexokinase activity (GO:1903299)2.81405319
150regulation of glucokinase activity (GO:0033131)2.81405319
151establishment of viral latency (GO:0019043)2.81135427
152NAD metabolic process (GO:0019674)2.80626976
153DNA strand elongation involved in DNA replication (GO:0006271)2.80340752
154peptidyl-glutamic acid carboxylation (GO:0017187)2.79648965
155protein carboxylation (GO:0018214)2.79648965
156signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.78871684
157signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.78871684
158signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.78871684
159inner mitochondrial membrane organization (GO:0007007)2.77877183
160biotin metabolic process (GO:0006768)2.77798748
161RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.76735807
162macromolecular complex remodeling (GO:0034367)2.76549990
163plasma lipoprotein particle remodeling (GO:0034369)2.76549990
164protein-lipid complex remodeling (GO:0034368)2.76549990
165positive regulation of histone H3-K4 methylation (GO:0051571)2.75487556
166phospholipid homeostasis (GO:0055091)2.75195585
167aldehyde catabolic process (GO:0046185)2.74480500
168anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.73881697
169regulation of sulfur metabolic process (GO:0042762)2.73198850
170positive regulation of chromosome segregation (GO:0051984)2.71962525
171signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.71254425
172intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.71254425
173signal transduction involved in DNA damage checkpoint (GO:0072422)2.71142041
174signal transduction involved in DNA integrity checkpoint (GO:0072401)2.71142041
175somatic recombination of immunoglobulin gene segments (GO:0016447)2.70883843
176signal transduction involved in cell cycle checkpoint (GO:0072395)2.70622055
177somatic diversification of immunoglobulins (GO:0016445)2.69987414
178DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.69591171
179prenylation (GO:0097354)2.67088644
180protein prenylation (GO:0018342)2.67088644
181CENP-A containing nucleosome assembly (GO:0034080)2.64662070
182regulation of cellular amino acid metabolic process (GO:0006521)2.64033218
183chromatin remodeling at centromere (GO:0031055)2.63239465
184DNA strand elongation (GO:0022616)2.62529738
185telomere maintenance via semi-conservative replication (GO:0032201)2.61477202
186negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.61365973
187negative regulation of ligase activity (GO:0051352)2.61365973
188regulation of centriole replication (GO:0046599)2.60980876
189DNA-dependent DNA replication (GO:0006261)2.60432683
190mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.60406724
191mitochondrial respiratory chain complex I assembly (GO:0032981)2.60406724
192NADH dehydrogenase complex assembly (GO:0010257)2.60406724
193recombinational repair (GO:0000725)2.59965265
194synapsis (GO:0007129)2.59947680
195dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.59815710

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.05284552
2* PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.59726781
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.20349472
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.01107333
5E2F7_22180533_ChIP-Seq_HELA_Human3.93937562
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.65204139
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.39920998
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.07529129
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.72552673
10ELK1_19687146_ChIP-ChIP_HELA_Human2.68161702
11GATA1_22025678_ChIP-Seq_K562_Human2.64556618
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.61611965
13* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.58069259
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.53820281
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.43542024
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.40261014
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.38837293
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.25585943
19PADI4_21655091_ChIP-ChIP_MCF-7_Human2.23085337
20VDR_23849224_ChIP-Seq_CD4+_Human2.20123373
21FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.10779616
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09363100
23MYC_22102868_ChIP-Seq_BL_Human2.06643408
24CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.06008840
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.03594723
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.02031413
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99222441
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.97192473
29* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.96981959
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.95597941
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85850307
32FUS_26573619_Chip-Seq_HEK293_Human1.80018709
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78831047
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74506263
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.73999570
36ZNF274_21170338_ChIP-Seq_K562_Hela1.70114203
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.69867140
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.67140661
39CLOCK_20551151_ChIP-Seq_293T_Human1.66682806
40MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.66619215
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66513241
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.64063113
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.63284119
44EWS_26573619_Chip-Seq_HEK293_Human1.62714958
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59197637
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.56611172
47* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54937510
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52113503
49VDR_21846776_ChIP-Seq_THP-1_Human1.51699888
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.51433473
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50934170
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.49323016
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48999496
54* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48800930
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47354008
56MYC_18940864_ChIP-ChIP_HL60_Human1.41465361
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40651624
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.40158419
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39573744
60FOXM1_23109430_ChIP-Seq_U2OS_Human1.38696701
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38538199
62BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37248652
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36950757
64TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.36578837
65GATA1_22383799_ChIP-Seq_G1ME_Mouse1.35588083
66ZNF263_19887448_ChIP-Seq_K562_Human1.34656855
67NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34627229
68MYC_18358816_ChIP-ChIP_MESCs_Mouse1.33134957
69PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.32824557
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32803778
71AR_21909140_ChIP-Seq_LNCAP_Human1.31937798
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31668011
73TTF2_22483619_ChIP-Seq_HELA_Human1.30786746
74ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.30161408
75MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28378523
76ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27201320
77SCL_19346495_ChIP-Seq_HPC-7_Human1.26439707
78ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24569927
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.24421640
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24379710
81NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23309959
82TAF15_26573619_Chip-Seq_HEK293_Human1.20299502
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19593270
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17714904
85MAF_26560356_Chip-Seq_TH1_Human1.17237507
86GATA1_19941827_ChIP-Seq_MEL_Mouse1.17117584
87RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16595307
88IGF1R_20145208_ChIP-Seq_DFB_Human1.16028981
89CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15977616
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15873872
91* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15600910
92ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14020805
93E2F4_17652178_ChIP-ChIP_JURKAT_Human1.12692927
94MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12518532
95P300_19829295_ChIP-Seq_ESCs_Human1.12093582
96POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11777178
97MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10994184
98SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10788843
99MYC_19030024_ChIP-ChIP_MESCs_Mouse1.10583530
100HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10580467
101HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09672064
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09288665
103DCP1A_22483619_ChIP-Seq_HELA_Human1.09149184
104GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08807413
105PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07994231
106UTX_26944678_Chip-Seq_JUKART_Human1.07019007
107ATF3_27146783_Chip-Seq_COLON_Human1.06823745
108RUNX1_22412390_ChIP-Seq_EML_Mouse1.05563154
109TFEB_21752829_ChIP-Seq_HELA_Human1.04370322
110VDR_22108803_ChIP-Seq_LS180_Human1.04320998
111KDM5A_27292631_Chip-Seq_BREAST_Human1.02612690
112TCF7_22412390_ChIP-Seq_EML_Mouse1.01987915
113ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01739325
114GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00815510
115FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.00178091
116* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00161135
117EST1_17652178_ChIP-ChIP_JURKAT_Human0.99846743
118GBX2_23144817_ChIP-Seq_PC3_Human0.99835362
119* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99687689
120GATA6_25053715_ChIP-Seq_YYC3_Human0.98894606
121STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98851370
122SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98758390
123KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.98027757
124XRN2_22483619_ChIP-Seq_HELA_Human0.97846209
125NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97244825
126CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96881742
127SPI1_23547873_ChIP-Seq_NB4_Human0.96863617
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96610972
129GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96153099
130SRF_21415370_ChIP-Seq_HL-1_Mouse0.95671395
131SOX17_20123909_ChIP-Seq_XEN_Mouse0.95232786
132FOXP3_21729870_ChIP-Seq_TREG_Human0.95129875
133* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94535437
134E2F1_21310950_ChIP-Seq_MCF-7_Human0.93905412
135SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93729560
136ELK1_22589737_ChIP-Seq_MCF10A_Human0.93679070
137EZH2_27294783_Chip-Seq_NPCs_Mouse0.93402535
138AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92914719
139* GABP_19822575_ChIP-Seq_HepG2_Human0.92902919
140LXR_22292898_ChIP-Seq_THP-1_Human0.91825734
141KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91817171
142MYB_26560356_Chip-Seq_TH1_Human0.91465052
143SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.91361929
144CIITA_25753668_ChIP-Seq_RAJI_Human0.91150142
145YY1_21170310_ChIP-Seq_MESCs_Mouse0.90878923
146ELF5_23300383_ChIP-Seq_T47D_Human0.90636103
147SOX2_19829295_ChIP-Seq_ESCs_Human0.90017444
148NANOG_19829295_ChIP-Seq_ESCs_Human0.90017444
149E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89657570
150HNF4A_19822575_ChIP-Seq_HepG2_Human0.89407917
151NFE2_27457419_Chip-Seq_LIVER_Mouse0.89360507
152PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89015679
153FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.88795706
154* JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.88612756
155DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88373365
156KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87861846
157BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87843874
158GATA4_21415370_ChIP-Seq_HL-1_Mouse0.87821223
159SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86412668
160NANOG_16153702_ChIP-ChIP_HESCs_Human0.86279310
161CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82773882
162SALL4_22934838_ChIP-ChIP_CD34+_Human0.82673633
163IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.80533643
164CBP_20019798_ChIP-Seq_JUKART_Human0.80533643
165MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.80414102

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.38369411
2MP0002139_abnormal_hepatobiliary_system5.21246979
3MP0005365_abnormal_bile_salt4.06467054
4MP0008058_abnormal_DNA_repair3.90130493
5MP0005085_abnormal_gallbladder_physiolo3.84713449
6MP0010094_abnormal_chromosome_stability3.83517198
7MP0003806_abnormal_nucleotide_metabolis3.81571542
8MP0008057_abnormal_DNA_replication3.55355251
9MP0003252_abnormal_bile_duct3.24292090
10MP0008875_abnormal_xenobiotic_pharmacok2.86700731
11MP0003693_abnormal_embryo_hatching2.83813385
12MP0008877_abnormal_DNA_methylation2.66260358
13MP0001666_abnormal_nutrient_absorption2.50273100
14MP0010329_abnormal_lipoprotein_level2.47162722
15MP0000372_irregular_coat_pigmentation2.46476859
16MP0009840_abnormal_foam_cell2.39318858
17MP0003111_abnormal_nucleus_morphology2.37506301
18MP0004957_abnormal_blastocyst_morpholog2.33908594
19MP0009780_abnormal_chondrocyte_physiolo2.31367466
20MP0005083_abnormal_biliary_tract2.31049465
21MP0010234_abnormal_vibrissa_follicle2.26178069
22MP0004147_increased_porphyrin_level2.24784583
23MP0005332_abnormal_amino_acid2.24472526
24MP0003656_abnormal_erythrocyte_physiolo2.16368956
25MP0003786_premature_aging2.13942097
26MP0009697_abnormal_copulation2.09576330
27MP0003077_abnormal_cell_cycle2.02294642
28MP0002938_white_spotting2.01174307
29MP0002254_reproductive_system_inflammat1.99647972
30MP0003191_abnormal_cellular_cholesterol1.96586569
31MP0008007_abnormal_cellular_replicative1.94234543
32MP0003718_maternal_effect1.93666511
33MP0002837_dystrophic_cardiac_calcinosis1.87686862
34MP0004130_abnormal_muscle_cell1.87188932
35MP0000609_abnormal_liver_physiology1.86731598
36MP0006054_spinal_hemorrhage1.84754374
37MP0006072_abnormal_retinal_apoptosis1.82571455
38MP0006036_abnormal_mitochondrial_physio1.80999013
39MP0005379_endocrine/exocrine_gland_phen1.80677438
40MP0005319_abnormal_enzyme/_coenzyme1.77107963
41MP0009643_abnormal_urine_homeostasis1.73118903
42MP0005075_abnormal_melanosome_morpholog1.71139354
43MP0002163_abnormal_gland_morphology1.70699798
44MP0005058_abnormal_lysosome_morphology1.70595869
45MP0003195_calcinosis1.69391779
46MP0002102_abnormal_ear_morphology1.66385143
47MP0008932_abnormal_embryonic_tissue1.65675820
48MP0003868_abnormal_feces_composition1.65655574
49MP0002118_abnormal_lipid_homeostasis1.58854438
50MP0005584_abnormal_enzyme/coenzyme_acti1.57910417
51MP0004043_abnormal_pH_regulation1.56523143
52MP0003300_gastrointestinal_ulcer1.50757169
53MP0001661_extended_life_span1.47409588
54MP0003705_abnormal_hypodermis_morpholog1.46368775
55MP0008995_early_reproductive_senescence1.42758301
56MP0003221_abnormal_cardiomyocyte_apopto1.40267406
57MP0005253_abnormal_eye_physiology1.39581718
58MP0002396_abnormal_hematopoietic_system1.37855668
59MP0000598_abnormal_liver_morphology1.37179759
60MP0000516_abnormal_urinary_system1.35446239
61MP0005367_renal/urinary_system_phenotyp1.35446239
62MP0005187_abnormal_penis_morphology1.34245692
63MP0004019_abnormal_vitamin_homeostasis1.33361407
64MP0003172_abnormal_lysosome_physiology1.32921635
65MP0004084_abnormal_cardiac_muscle1.32688303
66MP0005408_hypopigmentation1.30883193
67MP0010352_gastrointestinal_tract_polyps1.30565299
68MP0005220_abnormal_exocrine_pancreas1.30166760
69MP0000569_abnormal_digit_pigmentation1.28610373
70MP0000647_abnormal_sebaceous_gland1.25294560
71MP0000427_abnormal_hair_cycle1.22290586
72MP0005666_abnormal_adipose_tissue1.22172877
73MP0003950_abnormal_plasma_membrane1.20899433
74MP0003646_muscle_fatigue1.18478547
75MP0005330_cardiomyopathy1.17071298
76MP0001529_abnormal_vocalization1.12916989
77MP0004264_abnormal_extraembryonic_tissu1.12911331
78MP0002090_abnormal_vision1.08294345
79MP0002138_abnormal_hepatobiliary_system1.08068923
80MP0001764_abnormal_homeostasis1.07082560
81MP0005636_abnormal_mineral_homeostasis1.06972069
82MP0003186_abnormal_redox_activity1.06709268
83MP0006035_abnormal_mitochondrial_morpho1.05491362
84MP0004185_abnormal_adipocyte_glucose1.04986201
85MP0002078_abnormal_glucose_homeostasis1.04588329
86MP0005551_abnormal_eye_electrophysiolog1.04274138
87MP0000604_amyloidosis1.03750419
88MP0002269_muscular_atrophy1.03655000
89MP0008469_abnormal_protein_level1.02980275
90MP0005645_abnormal_hypothalamus_physiol1.02794237
91MP0004233_abnormal_muscle_weight1.02271081
92MP0000613_abnormal_salivary_gland1.02132184
93MP0005464_abnormal_platelet_physiology1.00924540
94MP0003941_abnormal_skin_development1.00503858
95MP0003011_delayed_dark_adaptation1.00243073
96MP0000747_muscle_weakness0.96885478
97MP0010678_abnormal_skin_adnexa0.94964816
98MP0005174_abnormal_tail_pigmentation0.94200130
99MP0008775_abnormal_heart_ventricle0.94189245
100MP0002876_abnormal_thyroid_physiology0.94089048
101MP0001730_embryonic_growth_arrest0.94003358
102MP0001697_abnormal_embryo_size0.93404378
103MP0001929_abnormal_gametogenesis0.93055784
104MP0001545_abnormal_hematopoietic_system0.92487397
105MP0005397_hematopoietic_system_phenotyp0.92487397
106MP0005248_abnormal_Harderian_gland0.91296797
107MP0001293_anophthalmia0.90522707
108MP0002971_abnormal_brown_adipose0.89864990
109MP0003436_decreased_susceptibility_to0.89684129
110MP0004215_abnormal_myocardial_fiber0.89338493
111MP0001756_abnormal_urination0.88705856
112MP0005375_adipose_tissue_phenotype0.88416916
113MP0001324_abnormal_eye_pigmentation0.86753018
114MP0005395_other_phenotype0.86742463
115MP0003943_abnormal_hepatobiliary_system0.86651637
116MP0002234_abnormal_pharynx_morphology0.86556729
117MP0004087_abnormal_muscle_fiber0.85831983
118MP0005266_abnormal_metabolism0.85446835
119MP0002693_abnormal_pancreas_physiology0.84866543
120MP0009763_increased_sensitivity_to0.84384013
121MP0010307_abnormal_tumor_latency0.84142277
122MP0009764_decreased_sensitivity_to0.83442737
123MP0003566_abnormal_cell_adhesion0.83358061
124MP0002160_abnormal_reproductive_system0.83080039
125MP0003724_increased_susceptibility_to0.83050258
126MP0009642_abnormal_blood_homeostasis0.82246460
127MP0000751_myopathy0.82155231
128MP0010630_abnormal_cardiac_muscle0.80092325
129MP0009703_decreased_birth_body0.79198486
130MP0002136_abnormal_kidney_physiology0.78947753
131MP0000462_abnormal_digestive_system0.78805520
132MP0003937_abnormal_limbs/digits/tail_de0.78767018
133MP0004036_abnormal_muscle_relaxation0.78742518
134MP0000653_abnormal_sex_gland0.78649822
135MP0002006_tumorigenesis0.77784025
136MP0001544_abnormal_cardiovascular_syste0.77666859
137MP0005385_cardiovascular_system_phenoty0.77666859
138MP0002233_abnormal_nose_morphology0.77655028
139MP0005670_abnormal_white_adipose0.77395114
140MP0003787_abnormal_imprinting0.77377039
141MP0008872_abnormal_physiological_respon0.76797684
142MP0005334_abnormal_fat_pad0.76690527
143MP0002751_abnormal_autonomic_nervous0.76183011
144MP0002877_abnormal_melanocyte_morpholog0.75983347
145MP0005084_abnormal_gallbladder_morpholo0.75491935
146MP0005389_reproductive_system_phenotype0.74224804
147MP0002822_catalepsy0.73876448
148MP0001145_abnormal_male_reproductive0.73460192
149MP0000003_abnormal_adipose_tissue0.72837851
150MP0003890_abnormal_embryonic-extraembry0.72559062
151MP0002084_abnormal_developmental_patter0.72480644
152MP0001672_abnormal_embryogenesis/_devel0.72241186
153MP0009672_abnormal_birth_weight0.71931831
154MP0003567_abnormal_fetal_cardiomyocyte0.69699618
155MP0000358_abnormal_cell_content/0.68988230
156MP0000689_abnormal_spleen_morphology0.68780137
157MP0001765_abnormal_ion_homeostasis0.68638398
158MP0002970_abnormal_white_adipose0.68336625
159MP0000749_muscle_degeneration0.68284457
160MP0000490_abnormal_crypts_of0.66228645
161MP0001944_abnormal_pancreas_morphology0.65545075
162MP0003183_abnormal_peptide_metabolism0.64327077
163MP0008004_abnormal_stomach_pH0.64235778
164MP0001845_abnormal_inflammatory_respons0.63885655
165MP0003303_peritoneal_inflammation0.62992195
166MP0003283_abnormal_digestive_organ0.62647588
167MP0002166_altered_tumor_susceptibility0.62302222
168MP0003329_amyloid_beta_deposits0.58749628
169MP0006138_congestive_heart_failure0.58037337
170MP0005448_abnormal_energy_balance0.57451178

Predicted human phenotypes

RankGene SetZ-score
1Hyperammonemia (HP:0001987)4.06646492
2Hypoglycemic coma (HP:0001325)4.05095704
3Abnormality of aromatic amino acid family metabolism (HP:0004338)3.93765285
4Abnormality of fatty-acid metabolism (HP:0004359)3.93463859
5Ketosis (HP:0001946)3.84980725
6Xanthomatosis (HP:0000991)3.84690519
7Ketoacidosis (HP:0001993)3.81114984
8Abnormality of monocarboxylic acid metabolism (HP:0010996)3.78786728
9Intrahepatic cholestasis (HP:0001406)3.77692999
10Hypobetalipoproteinemia (HP:0003563)3.59147955
11Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.48179685
12Hyperglycinuria (HP:0003108)3.43370162
13Abnormality of dicarboxylic acid metabolism (HP:0010995)3.30624085
14Dicarboxylic aciduria (HP:0003215)3.30624085
15Deep venous thrombosis (HP:0002625)3.29746942
16Abnormality of glutamine family amino acid metabolism (HP:0010902)3.27135822
17Abnormality of serine family amino acid metabolism (HP:0010894)3.23625432
18Abnormality of glycine metabolism (HP:0010895)3.23625432
19Acute necrotizing encephalopathy (HP:0006965)3.15427997
20Acute encephalopathy (HP:0006846)3.08782396
21Progressive macrocephaly (HP:0004481)3.07410394
22Abnormality of sulfur amino acid metabolism (HP:0004339)3.04458512
23Myoglobinuria (HP:0002913)2.98420281
24Abnormality of aspartate family amino acid metabolism (HP:0010899)2.88825400
25Abnormality of the common coagulation pathway (HP:0010990)2.88469406
26Ragged-red muscle fibers (HP:0003200)2.85795688
27* Increased CSF lactate (HP:0002490)2.85162753
28Hypolipoproteinemia (HP:0010981)2.84815312
29Hyperglycinemia (HP:0002154)2.84652085
30Generalized aminoaciduria (HP:0002909)2.77435990
31Hyperlipoproteinemia (HP:0010980)2.77395400
32Gout (HP:0001997)2.76550199
33Type I transferrin isoform profile (HP:0003642)2.76320181
34Abnormal mitochondria in muscle tissue (HP:0008316)2.75502411
35Pancreatic islet-cell hyperplasia (HP:0004510)2.72871275
36Metabolic acidosis (HP:0001942)2.71974847
37Abnormality of purine metabolism (HP:0004352)2.68736646
38Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.65394385
39Hyperbilirubinemia (HP:0002904)2.63572081
40Methylmalonic acidemia (HP:0002912)2.63382327
41Neoplasm of the adrenal cortex (HP:0100641)2.63178207
42Abnormality of nucleobase metabolism (HP:0010932)2.63031301
43Chromsome breakage (HP:0040012)2.59346620
44Spastic diplegia (HP:0001264)2.56645374
45Fat malabsorption (HP:0002630)2.54420498
46Rhabdomyolysis (HP:0003201)2.54012591
47Colon cancer (HP:0003003)2.53988808
48Abnormality of the intrinsic pathway (HP:0010989)2.53928308
49Abnormality of pyrimidine metabolism (HP:0004353)2.51620611
50Abnormality of chromosome stability (HP:0003220)2.50007803
51Epidermoid cyst (HP:0200040)2.49020329
52Medial flaring of the eyebrow (HP:0010747)2.48306295
53Abnormality of serum amino acid levels (HP:0003112)2.47586900
54Late onset (HP:0003584)2.46966237
553-Methylglutaconic aciduria (HP:0003535)2.44651876
56Mucopolysacchariduria (HP:0008155)2.43696132
57Urinary glycosaminoglycan excretion (HP:0003541)2.43696132
58Abnormality of methionine metabolism (HP:0010901)2.43343112
59Hypoalphalipoproteinemia (HP:0003233)2.42740685
60* Mitochondrial inheritance (HP:0001427)2.42571009
61* Increased serum lactate (HP:0002151)2.42415581
62Abnormal protein glycosylation (HP:0012346)2.42306106
63Abnormal glycosylation (HP:0012345)2.42306106
64Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.42306106
65Abnormal protein N-linked glycosylation (HP:0012347)2.42306106
66Microvesicular hepatic steatosis (HP:0001414)2.42229864
67Prolonged partial thromboplastin time (HP:0003645)2.41546242
68* Lactic acidosis (HP:0003128)2.40840639
69Exercise-induced muscle cramps (HP:0003710)2.40268425
70Sensorimotor neuropathy (HP:0007141)2.38424680
71Abnormality of glycolysis (HP:0004366)2.36844614
72Delayed CNS myelination (HP:0002188)2.34931334
73Abnormality of vitamin B metabolism (HP:0004340)2.34375007
74Posterior subcapsular cataract (HP:0007787)2.30045413
75Nausea (HP:0002018)2.29682456
76Asymmetric septal hypertrophy (HP:0001670)2.29384999
77Conjunctival hamartoma (HP:0100780)2.29230065
78Abnormality of the pancreatic islet cells (HP:0006476)2.27984723
79Abnormality of endocrine pancreas physiology (HP:0012093)2.27984723
80Intestinal atresia (HP:0011100)2.27753004
81Ependymoma (HP:0002888)2.27745988
82Breast carcinoma (HP:0003002)2.26684444
83Hypothermia (HP:0002045)2.22965472
84Chromosomal breakage induced by crosslinking agents (HP:0003221)2.22791650
85Reticulocytosis (HP:0001923)2.21655923
86Hypoglycemic seizures (HP:0002173)2.21617524
87Hypokinesia (HP:0002375)2.21045942
88Abnormality of alanine metabolism (HP:0010916)2.20383640
89Hyperalaninemia (HP:0003348)2.20383640
90Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.20383640
91Glioma (HP:0009733)2.20051826
92Acanthocytosis (HP:0001927)2.19361893
93Lethargy (HP:0001254)2.19100352
94Reduced antithrombin III activity (HP:0001976)2.18151183
95Hepatocellular carcinoma (HP:0001402)2.16335973
96Methylmalonic aciduria (HP:0012120)2.16290914
97Hyperinsulinemic hypoglycemia (HP:0000825)2.16123940
98Palpitations (HP:0001962)2.15996160
99Proximal tubulopathy (HP:0000114)2.13597098
100Volvulus (HP:0002580)2.13029250
101Lipid accumulation in hepatocytes (HP:0006561)2.13028394
102Abnormality of the labia minora (HP:0012880)2.12253644
103Abnormality of polysaccharide metabolism (HP:0011012)2.12223625
104Abnormality of glycosaminoglycan metabolism (HP:0004371)2.12223625
105Abnormality of mucopolysaccharide metabolism (HP:0011020)2.12223625
106Increased hepatocellular lipid droplets (HP:0006565)2.10834360
107Hyperglycemia (HP:0003074)2.10568964
108Increased serum pyruvate (HP:0003542)2.08934300
109Acute hepatic failure (HP:0006554)2.07647904
110Poikilocytosis (HP:0004447)2.07597411
111Abnormality of transition element cation homeostasis (HP:0011030)2.07569720
112Impaired platelet aggregation (HP:0003540)2.07532941
113Abnormal platelet function (HP:0011869)2.07532941
114* Hepatic necrosis (HP:0002605)2.06067502
115Cholelithiasis (HP:0001081)2.05688846
116* Hepatocellular necrosis (HP:0001404)2.05294431
117Joint hemorrhage (HP:0005261)2.05191921
118Meckel diverticulum (HP:0002245)2.04956655
119Pancreatic cysts (HP:0001737)2.04353055
120Abnormality of the preputium (HP:0100587)2.03649338
121Neoplasm of the adrenal gland (HP:0100631)2.03420838
122Complement deficiency (HP:0004431)2.03393388
123Abnormality of the ileum (HP:0001549)2.03391820
124Increased muscle lipid content (HP:0009058)2.03237073
125Rhabdomyosarcoma (HP:0002859)2.03121197
126Increased serum ferritin (HP:0003281)2.02867312
127Congenital primary aphakia (HP:0007707)2.02689054
128Hypercholesterolemia (HP:0003124)2.01739620
129Abnormality of iron homeostasis (HP:0011031)2.01580397
130Skin nodule (HP:0200036)2.01304062
131* Respiratory failure (HP:0002878)1.99884740
132Abnormality of the vitamin B12 metabolism (HP:0004341)1.99790287
133Renal cortical cysts (HP:0000803)1.97613177
134Abnormality of proline metabolism (HP:0010907)1.97484712
135Hydroxyprolinuria (HP:0003080)1.97484712
136Vomiting (HP:0002013)1.96124445
137Myocardial infarction (HP:0001658)1.96099972
138Pheochromocytoma (HP:0002666)1.95136314
139Abnormal gallbladder morphology (HP:0012437)1.94172976
140Medulloblastoma (HP:0002885)1.93510607
141Dysostosis multiplex (HP:0000943)1.93455906
142Nephrogenic diabetes insipidus (HP:0009806)1.91977576
143Symptomatic seizures (HP:0011145)1.91861420
144Exercise intolerance (HP:0003546)1.91683425
145Large for gestational age (HP:0001520)1.91208168
146Abnormality of the pons (HP:0007361)1.90985917
147Short tibia (HP:0005736)1.90892481
148Cerebral edema (HP:0002181)1.89776046
149Aplasia/Hypoplasia of the uvula (HP:0010293)1.89705586
150Astrocytoma (HP:0009592)1.89179225
151Abnormality of the astrocytes (HP:0100707)1.89179225
152Molar tooth sign on MRI (HP:0002419)1.87298811
153Abnormality of midbrain morphology (HP:0002418)1.87298811
154Degeneration of anterior horn cells (HP:0002398)1.87255060
155Abnormality of the anterior horn cell (HP:0006802)1.87255060
156Abnormality of the renal cortex (HP:0011035)1.86431354
157Increased mean platelet volume (HP:0011877)1.85412769
158Prominent metopic ridge (HP:0005487)1.84894918
159Neuroendocrine neoplasm (HP:0100634)1.84828677
160Sloping forehead (HP:0000340)1.84122417
161Thrombocytosis (HP:0001894)1.83701333
162Abnormality of lateral ventricle (HP:0030047)1.83649903
163Malnutrition (HP:0004395)1.82548983
164Hyperuricemia (HP:0002149)1.81981063
165Increased purine levels (HP:0004368)1.81981063
166Progressive muscle weakness (HP:0003323)1.81169944
167Glycosuria (HP:0003076)1.81033444
168Abnormality of urine glucose concentration (HP:0011016)1.81033444
169Gait imbalance (HP:0002141)1.80965622
170Meningioma (HP:0002858)1.79129010
171Conjugated hyperbilirubinemia (HP:0002908)1.78444781
172Neonatal onset (HP:0003623)1.78184350
173Hamartoma of the eye (HP:0010568)1.78110493
174Aplasia/Hypoplasia of the tibia (HP:0005772)1.77895722
175Megaloblastic anemia (HP:0001889)1.76732020
176Vascular calcification (HP:0004934)1.76344983
177Pancreatitis (HP:0001733)1.73969770
178Steatorrhea (HP:0002570)1.67823377

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.26736594
2MST44.13372357
3PKN24.11868714
4TRIB33.66998732
5ERN13.53469287
6BUB13.30242325
7TRIM283.19686006
8ZAK2.96211738
9VRK22.73670707
10FLT32.70878216
11NEK12.58561118
12EIF2AK12.44768703
13MAP3K102.30488858
14MAP4K22.21941165
15SRPK12.21596104
16SCYL22.18370663
17TAF12.12849852
18PLK32.12653430
19TTN2.06875483
20WNK32.02325817
21PBK2.01894883
22MKNK11.95230629
23TTK1.92701777
24MKNK21.90788883
25BRD41.87251154
26LMTK21.86308001
27PDK41.80887564
28PDK31.80887564
29EEF2K1.76486660
30TAOK31.69400166
31BMPR1B1.66554810
32NUAK11.63621399
33STK391.62689989
34FGFR41.61207097
35VRK11.59156872
36NEK91.58627236
37LRRK21.49827860
38STK161.44619662
39PTK61.43003879
40TYK21.38261388
41OXSR11.34962932
42KDR1.34957196
43ERBB31.33753942
44STK101.33687010
45PHKG11.27244313
46PHKG21.27244313
47TBK11.26243039
48CDC71.24081055
49NME21.23441050
50PLK41.22664798
51MAP2K31.22116354
52GRK61.20830805
53PNCK1.20481376
54CSNK1G11.20198545
55SIK31.20077232
56BCR1.18954393
57WNK41.18682405
58EIF2AK31.16938519
59SIK11.16089423
60TSSK61.15940586
61CSNK1A1L1.14260749
62TNIK1.12627223
63BMX1.09739169
64GRK11.09729881
65INSRR1.08342287
66JAK21.06105304
67STK38L1.05688696
68ATR1.04848685
69CSNK1G31.02111959
70MAP4K11.01692703
71PLK11.01287870
72MAPK111.00221323
73PAK41.00117278
74CCNB10.98997012
75CDK60.98333565
76RPS6KB20.97346248
77MAP3K80.95484893
78RIPK10.94371406
79FRK0.94039741
80IRAK30.93869698
81STK30.93829940
82CSF1R0.92883001
83EIF2AK20.91690905
84DYRK1B0.87764655
85ZAP700.85401676
86JAK10.84788726
87JAK30.84286659
88RET0.83242369
89CHEK20.83238990
90FGFR20.79100308
91ATM0.78428438
92PIM20.77111052
93MAP2K40.77013125
94EPHB10.76220935
95PINK10.75977493
96MAPKAPK30.74938725
97MAP3K110.74533001
98STK40.73706167
99CSNK1G20.71197729
100MET0.69604498
101CDK120.69242251
102PIM10.67701946
103PLK20.66572949
104AURKB0.63087630
105MAP3K20.62459592
106MTOR0.61719425
107ITK0.61394894
108DAPK10.60305711
109MAP2K20.59600718
110CDK30.59343353
111PDK10.59318934
112CASK0.59007608
113TGFBR20.58824795
114MAPKAPK50.58631699
115TESK20.58171092
116MAP3K70.57973370
117PASK0.57866246
118MYLK0.56664021
119PDPK10.56610363
120CDK40.55620925
121CHEK10.54346512
122PRKAA10.54328527
123ADRBK20.53762924
124PDGFRA0.53365434
125GSK3A0.53338095
126MAP2K10.52771781
127STK240.52481149
128BTK0.51610414
129MAP3K120.50876480
130PRKAA20.50720894
131EPHA30.50303419
132PDK20.50113147
133NEK20.48815463
134KSR20.48621453
135PRKG20.48527647
136BRSK10.47347055
137PAK30.47262080
138RPS6KA40.46890488
139MAP3K50.46180540
140TGFBR10.45695910
141FER0.44303145
142CSK0.43804307
143NME10.43615901
144AKT20.43468846
145TEC0.42918004
146BRSK20.42385170
147RAF10.41838768
148PIK3CG0.41786331
149PRKCE0.41458724
150PRKDC0.41404838
151PRKCI0.40636681
152MST1R0.40552373
153CSNK2A20.40051440
154YES10.39923318
155DAPK30.39803593
156MAPK40.39510786
157KIT0.39284577
158MELK0.38835123
159OBSCN0.38645147
160ERBB40.38596267
161ACVR1B0.38211511
162CSNK2A10.38192472
163PTK20.36721128
164SYK0.36695366
165PRKACG0.36043392
166MAP3K40.36033621
167WEE10.35832412
168CDK80.34974591
169KSR10.33367133
170RPS6KA50.33320010
171CSNK1E0.30327736
172AKT30.29211406
173RPS6KB10.29114329

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.82642732
2Non-homologous end-joining_Homo sapiens_hsa034503.64210723
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.58226457
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.50835916
5Proteasome_Homo sapiens_hsa030503.07013097
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.86463572
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.85038924
8Fatty acid degradation_Homo sapiens_hsa000712.84198915
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.59952333
10Propanoate metabolism_Homo sapiens_hsa006402.51546495
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.43274514
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.38869727
13Carbon metabolism_Homo sapiens_hsa012002.35291931
14Tryptophan metabolism_Homo sapiens_hsa003802.33284955
15Nitrogen metabolism_Homo sapiens_hsa009102.30815949
16Arginine biosynthesis_Homo sapiens_hsa002202.28129110
17Homologous recombination_Homo sapiens_hsa034402.25111039
18Vitamin B6 metabolism_Homo sapiens_hsa007502.09357128
19Biosynthesis of amino acids_Homo sapiens_hsa012302.07387775
20Selenocompound metabolism_Homo sapiens_hsa004502.04454337
21Butanoate metabolism_Homo sapiens_hsa006502.04095137
22Fatty acid metabolism_Homo sapiens_hsa012122.00234027
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.96088661
24Pyruvate metabolism_Homo sapiens_hsa006201.95461938
25RNA polymerase_Homo sapiens_hsa030201.86127262
26Fanconi anemia pathway_Homo sapiens_hsa034601.85310179
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.84458935
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.78944710
29* Oxidative phosphorylation_Homo sapiens_hsa001901.78243487
30Peroxisome_Homo sapiens_hsa041461.77679707
31Folate biosynthesis_Homo sapiens_hsa007901.73565315
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.72733163
33Nucleotide excision repair_Homo sapiens_hsa034201.67552866
34One carbon pool by folate_Homo sapiens_hsa006701.67379191
35Starch and sucrose metabolism_Homo sapiens_hsa005001.66455551
36Basal transcription factors_Homo sapiens_hsa030221.63671333
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.60313603
38RNA degradation_Homo sapiens_hsa030181.58435913
39RNA transport_Homo sapiens_hsa030131.55962622
40Base excision repair_Homo sapiens_hsa034101.54058117
41Fat digestion and absorption_Homo sapiens_hsa049751.52651347
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51966537
43PPAR signaling pathway_Homo sapiens_hsa033201.51806563
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.46633607
45beta-Alanine metabolism_Homo sapiens_hsa004101.43727843
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.42140025
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.41193508
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.41099149
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35444677
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.35010655
51Drug metabolism - other enzymes_Homo sapiens_hsa009831.34492350
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31438567
53Caffeine metabolism_Homo sapiens_hsa002321.25748883
54Pentose phosphate pathway_Homo sapiens_hsa000301.23748160
55Steroid biosynthesis_Homo sapiens_hsa001001.23213322
56Pyrimidine metabolism_Homo sapiens_hsa002401.21472996
57Sulfur metabolism_Homo sapiens_hsa009201.18414463
58Complement and coagulation cascades_Homo sapiens_hsa046101.17879539
59Lysine degradation_Homo sapiens_hsa003101.16154342
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13811156
61Spliceosome_Homo sapiens_hsa030401.09448765
62Sulfur relay system_Homo sapiens_hsa041221.09398962
63Bile secretion_Homo sapiens_hsa049761.08501829
64Purine metabolism_Homo sapiens_hsa002301.05901132
65Huntingtons disease_Homo sapiens_hsa050161.00504060
66Galactose metabolism_Homo sapiens_hsa000520.98598839
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.95639173
68Vitamin digestion and absorption_Homo sapiens_hsa049770.94997637
69Cell cycle_Homo sapiens_hsa041100.94650793
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93340281
71* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92691187
72Fructose and mannose metabolism_Homo sapiens_hsa000510.90081195
73Histidine metabolism_Homo sapiens_hsa003400.87303597
74ABC transporters_Homo sapiens_hsa020100.85549969
75Phenylalanine metabolism_Homo sapiens_hsa003600.85528537
76Arginine and proline metabolism_Homo sapiens_hsa003300.80729777
77Alzheimers disease_Homo sapiens_hsa050100.79504837
78Regulation of autophagy_Homo sapiens_hsa041400.74926643
79Glycerolipid metabolism_Homo sapiens_hsa005610.73606824
80Fatty acid elongation_Homo sapiens_hsa000620.72833053
81Renin-angiotensin system_Homo sapiens_hsa046140.71919068
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70354533
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64543893
84DNA replication_Homo sapiens_hsa030300.63764495
85Staphylococcus aureus infection_Homo sapiens_hsa051500.62816424
86Circadian rhythm_Homo sapiens_hsa047100.62376726
87Insulin resistance_Homo sapiens_hsa049310.61931954
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60237732
89Other glycan degradation_Homo sapiens_hsa005110.59417525
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.58533538
91Glutathione metabolism_Homo sapiens_hsa004800.57991859
92p53 signaling pathway_Homo sapiens_hsa041150.57562863
93Tyrosine metabolism_Homo sapiens_hsa003500.57016702
94Chemical carcinogenesis_Homo sapiens_hsa052040.56831981
95N-Glycan biosynthesis_Homo sapiens_hsa005100.55966706
96Oocyte meiosis_Homo sapiens_hsa041140.55960203
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52914205
98Retinol metabolism_Homo sapiens_hsa008300.52383694
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.50353617
100mRNA surveillance pathway_Homo sapiens_hsa030150.48649106
101Ether lipid metabolism_Homo sapiens_hsa005650.47184599
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.46908544
103* Metabolic pathways_Homo sapiens_hsa011000.45848930
104Phototransduction_Homo sapiens_hsa047440.45134971
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44301395
106Lysosome_Homo sapiens_hsa041420.40823429
107Collecting duct acid secretion_Homo sapiens_hsa049660.40438506
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.39791146
109AMPK signaling pathway_Homo sapiens_hsa041520.39308595
110Insulin signaling pathway_Homo sapiens_hsa049100.38074177
111Linoleic acid metabolism_Homo sapiens_hsa005910.37229146
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36215914
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35178642
114Sphingolipid metabolism_Homo sapiens_hsa006000.34797230
115Legionellosis_Homo sapiens_hsa051340.32643326
116Glucagon signaling pathway_Homo sapiens_hsa049220.31819562
117Thyroid cancer_Homo sapiens_hsa052160.31718261
118Fatty acid biosynthesis_Homo sapiens_hsa000610.31672039
119Antigen processing and presentation_Homo sapiens_hsa046120.30369304
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29076067
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28831981
122Ribosome_Homo sapiens_hsa030100.26338390
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26330984
124TGF-beta signaling pathway_Homo sapiens_hsa043500.26304406
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26024793
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24699363
127Systemic lupus erythematosus_Homo sapiens_hsa053220.23366989
128Viral myocarditis_Homo sapiens_hsa054160.20517979
129Acute myeloid leukemia_Homo sapiens_hsa052210.18812489
130Parkinsons disease_Homo sapiens_hsa050120.17825515
131Bladder cancer_Homo sapiens_hsa052190.17758444
132Protein digestion and absorption_Homo sapiens_hsa049740.16754662
133Apoptosis_Homo sapiens_hsa042100.08262300
134mTOR signaling pathway_Homo sapiens_hsa041500.06035525
135HIF-1 signaling pathway_Homo sapiens_hsa040660.04416973
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.03984637
137Protein export_Homo sapiens_hsa030600.03286607
138Mismatch repair_Homo sapiens_hsa034300.02397696
139Non-small cell lung cancer_Homo sapiens_hsa052230.02357875
140Viral carcinogenesis_Homo sapiens_hsa052030.00887051

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