

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 7.04923119 |
| 2 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 6.86597889 |
| 3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 6.84624277 |
| 4 | ATP synthesis coupled proton transport (GO:0015986) | 6.84624277 |
| 5 | respiratory electron transport chain (GO:0022904) | 5.87988217 |
| 6 | electron transport chain (GO:0022900) | 5.74898130 |
| 7 | protein complex biogenesis (GO:0070271) | 5.19954234 |
| 8 | cotranslational protein targeting to membrane (GO:0006613) | 5.11755135 |
| 9 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 5.10736013 |
| 10 | viral transcription (GO:0019083) | 5.04734062 |
| 11 | protein targeting to ER (GO:0045047) | 5.03962925 |
| 12 | ribosomal small subunit biogenesis (GO:0042274) | 5.03349778 |
| 13 | translational termination (GO:0006415) | 4.86931225 |
| 14 | chaperone-mediated protein transport (GO:0072321) | 4.84112643 |
| 15 | protein localization to endoplasmic reticulum (GO:0070972) | 4.84039757 |
| 16 | ribosomal small subunit assembly (GO:0000028) | 4.80683745 |
| 17 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.76495673 |
| 18 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.74712414 |
| 19 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.74712414 |
| 20 | NADH dehydrogenase complex assembly (GO:0010257) | 4.74712414 |
| 21 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.59644399 |
| 22 | protein neddylation (GO:0045116) | 4.47801766 |
| 23 | respiratory chain complex IV assembly (GO:0008535) | 4.28866578 |
| 24 | proteasome assembly (GO:0043248) | 4.02649972 |
| 25 | GTP biosynthetic process (GO:0006183) | 4.00239930 |
| 26 | cytochrome complex assembly (GO:0017004) | 3.98589282 |
| 27 | signal peptide processing (GO:0006465) | 3.91575586 |
| 28 | translational elongation (GO:0006414) | 3.90355080 |
| 29 | viral life cycle (GO:0019058) | 3.86784938 |
| 30 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.83650343 |
| 31 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.80080981 |
| 32 | regulation of mitochondrial translation (GO:0070129) | 3.79748484 |
| 33 | aldehyde catabolic process (GO:0046185) | 3.77571307 |
| 34 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.76938613 |
| 35 | cellular protein complex disassembly (GO:0043624) | 3.75889000 |
| 36 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.70653055 |
| 37 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.66028782 |
| 38 | termination of RNA polymerase III transcription (GO:0006386) | 3.66028782 |
| 39 | translation (GO:0006412) | 3.64041076 |
| 40 | ribosomal large subunit biogenesis (GO:0042273) | 3.60797212 |
| 41 | inner mitochondrial membrane organization (GO:0007007) | 3.59565606 |
| 42 | platelet dense granule organization (GO:0060155) | 3.52287366 |
| 43 | sequestering of actin monomers (GO:0042989) | 3.47724636 |
| 44 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.46013350 |
| 45 | hydrogen ion transmembrane transport (GO:1902600) | 3.45927960 |
| 46 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.43743730 |
| 47 | rRNA modification (GO:0000154) | 3.36207585 |
| 48 | chromatin remodeling at centromere (GO:0031055) | 3.31750124 |
| 49 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.31728864 |
| 50 | ATP biosynthetic process (GO:0006754) | 3.30520042 |
| 51 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.29554643 |
| 52 | translational initiation (GO:0006413) | 3.27292835 |
| 53 | maturation of SSU-rRNA (GO:0030490) | 3.27238496 |
| 54 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.26636849 |
| 55 | protein targeting to membrane (GO:0006612) | 3.25915881 |
| 56 | CENP-A containing nucleosome assembly (GO:0034080) | 3.25691865 |
| 57 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.24966584 |
| 58 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.24477232 |
| 59 | UTP biosynthetic process (GO:0006228) | 3.23584193 |
| 60 | proton transport (GO:0015992) | 3.19108968 |
| 61 | protein-cofactor linkage (GO:0018065) | 3.18952194 |
| 62 | intracellular protein transmembrane import (GO:0044743) | 3.18663982 |
| 63 | peptidyl-histidine modification (GO:0018202) | 3.17341668 |
| 64 | protein targeting to mitochondrion (GO:0006626) | 3.17301134 |
| 65 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.16721979 |
| 66 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.16721979 |
| 67 | DNA damage response, detection of DNA damage (GO:0042769) | 3.16312526 |
| 68 | cullin deneddylation (GO:0010388) | 3.15718859 |
| 69 | nucleotide transmembrane transport (GO:1901679) | 3.15176327 |
| 70 | hydrogen transport (GO:0006818) | 3.12040148 |
| 71 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.11755774 |
| 72 | metallo-sulfur cluster assembly (GO:0031163) | 3.11466153 |
| 73 | iron-sulfur cluster assembly (GO:0016226) | 3.11466153 |
| 74 | pseudouridine synthesis (GO:0001522) | 3.08335280 |
| 75 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.04375119 |
| 76 | oxidative phosphorylation (GO:0006119) | 3.03193477 |
| 77 | 7-methylguanosine mRNA capping (GO:0006370) | 3.02626677 |
| 78 | establishment of protein localization to mitochondrion (GO:0072655) | 3.02608461 |
| 79 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.00043750 |
| 80 | establishment of integrated proviral latency (GO:0075713) | 2.98888088 |
| 81 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.98433465 |
| 82 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.98433465 |
| 83 | RNA capping (GO:0036260) | 2.97373426 |
| 84 | 7-methylguanosine RNA capping (GO:0009452) | 2.97373426 |
| 85 | regulation of oxidative phosphorylation (GO:0002082) | 2.95160094 |
| 86 | protein complex disassembly (GO:0043241) | 2.93599018 |
| 87 | CTP biosynthetic process (GO:0006241) | 2.92394833 |
| 88 | CTP metabolic process (GO:0046036) | 2.92394833 |
| 89 | spliceosomal snRNP assembly (GO:0000387) | 2.90441597 |
| 90 | protein deneddylation (GO:0000338) | 2.90175191 |
| 91 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.89243832 |
| 92 | DNA double-strand break processing (GO:0000729) | 2.88490462 |
| 93 | macromolecular complex disassembly (GO:0032984) | 2.86010453 |
| 94 | behavioral response to nicotine (GO:0035095) | 2.85218832 |
| 95 | UTP metabolic process (GO:0046051) | 2.84887144 |
| 96 | mannosylation (GO:0097502) | 2.84867484 |
| 97 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.83622567 |
| 98 | organelle disassembly (GO:1903008) | 2.81194650 |
| 99 | GDP-mannose metabolic process (GO:0019673) | 2.81058180 |
| 100 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.78479854 |
| 101 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.78375741 |
| 102 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.78375741 |
| 103 | cellular component biogenesis (GO:0044085) | 2.75530875 |
| 104 | protein localization to mitochondrion (GO:0070585) | 2.75134446 |
| 105 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.73276512 |
| 106 | deoxyribonucleoside diphosphate metabolic process (GO:0009186) | 2.72850627 |
| 107 | histone exchange (GO:0043486) | 2.71152530 |
| 108 | GPI anchor biosynthetic process (GO:0006506) | 2.70502063 |
| 109 | positive regulation of ligase activity (GO:0051351) | 2.69878895 |
| 110 | nucleoside triphosphate biosynthetic process (GO:0009142) | 2.69662437 |
| 111 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.69643590 |
| 112 | aerobic respiration (GO:0009060) | 2.67401254 |
| 113 | DNA deamination (GO:0045006) | 2.66752319 |
| 114 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.66455517 |
| 115 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.66455517 |
| 116 | viral protein processing (GO:0019082) | 2.65659339 |
| 117 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.65131193 |
| 118 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.65131193 |
| 119 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.65131193 |
| 120 | regulation of cellular amine metabolic process (GO:0033238) | 2.64010907 |
| 121 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 2.62628206 |
| 122 | nucleoside diphosphate phosphorylation (GO:0006165) | 2.62492811 |
| 123 | dopamine transport (GO:0015872) | 2.62456016 |
| 124 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 2.61624190 |
| 125 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 2.61624190 |
| 126 | mitochondrial transport (GO:0006839) | 2.61612451 |
| 127 | maturation of 5.8S rRNA (GO:0000460) | 2.61549865 |
| 128 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.58778174 |
| 129 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.57156283 |
| 130 | negative regulation of ligase activity (GO:0051352) | 2.57156283 |
| 131 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 2.52753433 |
| 132 | deoxyribose phosphate biosynthetic process (GO:0046385) | 2.52753433 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 4.97738644 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.58127589 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.47986164 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.67618083 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.39730084 |
| 6 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.30352200 |
| 7 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 3.15567929 |
| 8 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.10743926 |
| 9 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.97089666 |
| 10 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.86685267 |
| 11 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.70046915 |
| 12 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.66697629 |
| 13 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.65622358 |
| 14 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.61421180 |
| 15 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.54654365 |
| 16 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.48687526 |
| 17 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.47752326 |
| 18 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.44905087 |
| 19 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.41595482 |
| 20 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.22750665 |
| 21 | VDR_22108803_ChIP-Seq_LS180_Human | 2.16559926 |
| 22 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.15198901 |
| 23 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 2.08083391 |
| 24 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.04496904 |
| 25 | EWS_26573619_Chip-Seq_HEK293_Human | 1.96157242 |
| 26 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.94402346 |
| 27 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.93319239 |
| 28 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.92100586 |
| 29 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.91235709 |
| 30 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.87288392 |
| 31 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.83196440 |
| 32 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.74013786 |
| 33 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.69886236 |
| 34 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.69296710 |
| 35 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.68830516 |
| 36 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 1.68166808 |
| 37 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.65074965 |
| 38 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.61583060 |
| 39 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.57130464 |
| 40 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.55094904 |
| 41 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.50873171 |
| 42 | * CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.49118290 |
| 43 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.48749393 |
| 44 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.48114939 |
| 45 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.46278653 |
| 46 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.45426113 |
| 47 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.45229230 |
| 48 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.44992439 |
| 49 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.43268354 |
| 50 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.43183655 |
| 51 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.40582996 |
| 52 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.40366910 |
| 53 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.39189307 |
| 54 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.36321776 |
| 55 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.35764114 |
| 56 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.35118822 |
| 57 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.32519414 |
| 58 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.31237757 |
| 59 | * TTF2_22483619_ChIP-Seq_HELA_Human | 1.29837017 |
| 60 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.28491405 |
| 61 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.27603813 |
| 62 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.26947907 |
| 63 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.26437490 |
| 64 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.26141577 |
| 65 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.25792159 |
| 66 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.23746036 |
| 67 | * TP53_22573176_ChIP-Seq_HFKS_Human | 1.23364448 |
| 68 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.23352814 |
| 69 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.22492882 |
| 70 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.21150253 |
| 71 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.18256001 |
| 72 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.18030812 |
| 73 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.17229511 |
| 74 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.16192797 |
| 75 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.15975216 |
| 76 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.15062075 |
| 77 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.15054736 |
| 78 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.13268004 |
| 79 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.13044482 |
| 80 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.12946696 |
| 81 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.12916412 |
| 82 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.12163497 |
| 83 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.10952252 |
| 84 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.06874835 |
| 85 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.06874835 |
| 86 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.06748187 |
| 87 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.03270573 |
| 88 | * KAP1_22055183_ChIP-Seq_ESCs_Mouse | 1.01466012 |
| 89 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.98818791 |
| 90 | FUS_26573619_Chip-Seq_HEK293_Human | 0.98766961 |
| 91 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.97707863 |
| 92 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.96792390 |
| 93 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.96463709 |
| 94 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.95899542 |
| 95 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.95881624 |
| 96 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.95549874 |
| 97 | * BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.95248607 |
| 98 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.94001912 |
| 99 | P300_19829295_ChIP-Seq_ESCs_Human | 0.92716184 |
| 100 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.92503578 |
| 101 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.92165581 |
| 102 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.91567201 |
| 103 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.90560006 |
| 104 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 0.89125583 |
| 105 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.88291506 |
| 106 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.87771418 |
| 107 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.87583026 |
| 108 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 0.84933003 |
| 109 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.84846504 |
| 110 | * IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.84772571 |
| 111 | * CBP_20019798_ChIP-Seq_JUKART_Human | 0.84772571 |
| 112 | NCOR_22424771_ChIP-Seq_293T_Human | 0.84723689 |
| 113 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 0.84653055 |
| 114 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.84539666 |
| 115 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.84238418 |
| 116 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.83451643 |
| 117 | GBX2_23144817_ChIP-Seq_PC3_Human | 0.83239117 |
| 118 | RUNX1_27457419_Chip-Seq_LIVER_Mouse | 0.83101743 |
| 119 | AR_20517297_ChIP-Seq_VCAP_Human | 0.82870127 |
| 120 | NMYC_18555785_Chip-Seq_ESCs_Mouse | 0.81300692 |
| 121 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.81026861 |
| 122 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.80914394 |
| 123 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.80762905 |
| 124 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.80762905 |
| 125 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.80225697 |
| 126 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.80021856 |
| 127 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 0.79385731 |
| 128 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 0.78588066 |
| 129 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.77882699 |
| 130 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.77875980 |
| 131 | SMAD1_18555785_Chip-Seq_ESCs_Mouse | 0.76199009 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0009379_abnormal_foot_pigmentation | 5.50897683 |
| 2 | MP0001188_hyperpigmentation | 2.76443110 |
| 3 | MP0003724_increased_susceptibility_to | 2.68963324 |
| 4 | MP0001986_abnormal_taste_sensitivity | 2.67872431 |
| 5 | MP0002638_abnormal_pupillary_reflex | 2.48290716 |
| 6 | MP0006276_abnormal_autonomic_nervous | 2.41340157 |
| 7 | MP0003186_abnormal_redox_activity | 2.37875241 |
| 8 | MP0001529_abnormal_vocalization | 2.36917389 |
| 9 | MP0002876_abnormal_thyroid_physiology | 2.35426984 |
| 10 | MP0009697_abnormal_copulation | 2.34239302 |
| 11 | MP0002139_abnormal_hepatobiliary_system | 2.33456173 |
| 12 | MP0001905_abnormal_dopamine_level | 2.32683892 |
| 13 | MP0008877_abnormal_DNA_methylation | 2.21838469 |
| 14 | MP0008058_abnormal_DNA_repair | 2.21399945 |
| 15 | MP0003806_abnormal_nucleotide_metabolis | 2.17718538 |
| 16 | MP0005408_hypopigmentation | 2.12104767 |
| 17 | MP0005084_abnormal_gallbladder_morpholo | 2.08428264 |
| 18 | MP0003195_calcinosis | 2.06992991 |
| 19 | MP0006036_abnormal_mitochondrial_physio | 2.03658794 |
| 20 | MP0000372_irregular_coat_pigmentation | 1.99347021 |
| 21 | MP0005379_endocrine/exocrine_gland_phen | 1.93298556 |
| 22 | MP0001764_abnormal_homeostasis | 1.89117057 |
| 23 | MP0010386_abnormal_urinary_bladder | 1.80722338 |
| 24 | MP0005085_abnormal_gallbladder_physiolo | 1.78206983 |
| 25 | MP0002148_abnormal_hypersensitivity_rea | 1.75622545 |
| 26 | MP0003787_abnormal_imprinting | 1.72614033 |
| 27 | MP0003136_yellow_coat_color | 1.72462681 |
| 28 | MP0005360_urolithiasis | 1.69973653 |
| 29 | MP0008875_abnormal_xenobiotic_pharmacok | 1.66296761 |
| 30 | MP0003880_abnormal_central_pattern | 1.65829611 |
| 31 | MP0001485_abnormal_pinna_reflex | 1.61692175 |
| 32 | MP0004381_abnormal_hair_follicle | 1.60732610 |
| 33 | MP0003011_delayed_dark_adaptation | 1.59848771 |
| 34 | MP0009785_altered_susceptibility_to | 1.58935558 |
| 35 | MP0004133_heterotaxia | 1.57764533 |
| 36 | MP0003121_genomic_imprinting | 1.57619062 |
| 37 | MP0005636_abnormal_mineral_homeostasis | 1.54475290 |
| 38 | MP0008789_abnormal_olfactory_epithelium | 1.53311044 |
| 39 | MP0009046_muscle_twitch | 1.53170516 |
| 40 | MP0001984_abnormal_olfaction | 1.52817969 |
| 41 | MP0005671_abnormal_response_to | 1.50507058 |
| 42 | MP0005365_abnormal_bile_salt | 1.48329962 |
| 43 | MP0002938_white_spotting | 1.47748115 |
| 44 | MP0002693_abnormal_pancreas_physiology | 1.46302675 |
| 45 | MP0005646_abnormal_pituitary_gland | 1.44917000 |
| 46 | MP0005645_abnormal_hypothalamus_physiol | 1.43604642 |
| 47 | MP0005075_abnormal_melanosome_morpholog | 1.42965581 |
| 48 | MP0001293_anophthalmia | 1.42680715 |
| 49 | MP0002163_abnormal_gland_morphology | 1.42534397 |
| 50 | MP0008995_early_reproductive_senescence | 1.42483227 |
| 51 | MP0006035_abnormal_mitochondrial_morpho | 1.38782123 |
| 52 | MP0003890_abnormal_embryonic-extraembry | 1.36088609 |
| 53 | MP0002272_abnormal_nervous_system | 1.35678994 |
| 54 | MP0008872_abnormal_physiological_respon | 1.35170512 |
| 55 | MP0003122_maternal_imprinting | 1.34030170 |
| 56 | MP0001835_abnormal_antigen_presentation | 1.33135053 |
| 57 | MP0010094_abnormal_chromosome_stability | 1.32763913 |
| 58 | MP0002277_abnormal_respiratory_mucosa | 1.32214928 |
| 59 | MP0002132_abnormal_respiratory_system | 1.31877514 |
| 60 | MP0003868_abnormal_feces_composition | 1.31608181 |
| 61 | MP0002736_abnormal_nociception_after | 1.31430987 |
| 62 | MP0009745_abnormal_behavioral_response | 1.31009264 |
| 63 | MP0003123_paternal_imprinting | 1.30085979 |
| 64 | MP0005409_darkened_coat_color | 1.26636928 |
| 65 | MP0002160_abnormal_reproductive_system | 1.26596768 |
| 66 | MP0003786_premature_aging | 1.26448842 |
| 67 | MP0003693_abnormal_embryo_hatching | 1.23475609 |
| 68 | MP0004142_abnormal_muscle_tone | 1.23344357 |
| 69 | MP0005332_abnormal_amino_acid | 1.20870845 |
| 70 | MP0002735_abnormal_chemical_nociception | 1.20544047 |
| 71 | MP0004957_abnormal_blastocyst_morpholog | 1.20360654 |
| 72 | MP0006292_abnormal_olfactory_placode | 1.19524546 |
| 73 | MP0004147_increased_porphyrin_level | 1.18391760 |
| 74 | MP0001968_abnormal_touch/_nociception | 1.16264275 |
| 75 | MP0005000_abnormal_immune_tolerance | 1.14270745 |
| 76 | MP0005389_reproductive_system_phenotype | 1.11194497 |
| 77 | MP0002653_abnormal_ependyma_morphology | 1.08763344 |
| 78 | MP0004145_abnormal_muscle_electrophysio | 1.07706742 |
| 79 | MP0003941_abnormal_skin_development | 1.07190014 |
| 80 | MP0002234_abnormal_pharynx_morphology | 1.07119105 |
| 81 | MP0005083_abnormal_biliary_tract | 1.05215217 |
| 82 | MP0000015_abnormal_ear_pigmentation | 1.04852874 |
| 83 | MP0004043_abnormal_pH_regulation | 1.03081682 |
| 84 | MP0001542_abnormal_bone_strength | 1.02397625 |
| 85 | MP0003436_decreased_susceptibility_to | 1.02144341 |
| 86 | MP0005025_abnormal_response_to | 1.01803008 |
| 87 | MP0003567_abnormal_fetal_cardiomyocyte | 1.00894404 |
| 88 | MP0002909_abnormal_adrenal_gland | 0.97889388 |
| 89 | MP0002557_abnormal_social/conspecific_i | 0.97798356 |
| 90 | MP0002822_catalepsy | 0.97151097 |
| 91 | MP0008469_abnormal_protein_level | 0.97006941 |
| 92 | MP0003718_maternal_effect | 0.96635896 |
| 93 | MP0001919_abnormal_reproductive_system | 0.95260957 |
| 94 | MP0004885_abnormal_endolymph | 0.94990179 |
| 95 | MP0001486_abnormal_startle_reflex | 0.94576130 |
| 96 | MP0003183_abnormal_peptide_metabolism | 0.94522597 |
| 97 | MP0002210_abnormal_sex_determination | 0.93886417 |
| 98 | MP0006072_abnormal_retinal_apoptosis | 0.93545458 |
| 99 | MP0003119_abnormal_digestive_system | 0.92851297 |
| 100 | MP0005551_abnormal_eye_electrophysiolog | 0.92483568 |
| 101 | MP0001944_abnormal_pancreas_morphology | 0.91657205 |
| 102 | MP0006082_CNS_inflammation | 0.90750400 |
| 103 | MP0004782_abnormal_surfactant_physiolog | 0.90669430 |
| 104 | MP0005195_abnormal_posterior_eye | 0.90220833 |
| 105 | MP0001727_abnormal_embryo_implantation | 0.90100025 |
| 106 | MP0002837_dystrophic_cardiac_calcinosis | 0.90051407 |
| 107 | MP0004215_abnormal_myocardial_fiber | 0.89532902 |
| 108 | MP0005253_abnormal_eye_physiology | 0.89488238 |
| 109 | MP0000049_abnormal_middle_ear | 0.89455467 |
| 110 | MP0002751_abnormal_autonomic_nervous | 0.89301001 |
| 111 | MP0002419_abnormal_innate_immunity | 0.88832775 |
| 112 | MP0003315_abnormal_perineum_morphology | 0.88136536 |
| 113 | MP0008932_abnormal_embryonic_tissue | 0.87451594 |
| 114 | MP0002233_abnormal_nose_morphology | 0.86778427 |
| 115 | MP0002090_abnormal_vision | 0.86715674 |
| 116 | MP0002572_abnormal_emotion/affect_behav | 0.85739181 |
| 117 | MP0003937_abnormal_limbs/digits/tail_de | 0.85241197 |
| 118 | MP0009643_abnormal_urine_homeostasis | 0.85221235 |
| 119 | MP0000538_abnormal_urinary_bladder | 0.84612699 |
| 120 | MP0000631_abnormal_neuroendocrine_gland | 0.84367630 |
| 121 | MP0005394_taste/olfaction_phenotype | 0.84325725 |
| 122 | MP0005499_abnormal_olfactory_system | 0.84325725 |
| 123 | MP0005220_abnormal_exocrine_pancreas | 0.84273348 |
| 124 | MP0001970_abnormal_pain_threshold | 0.82143251 |
| 125 | MP0004019_abnormal_vitamin_homeostasis | 0.81815788 |
| 126 | MP0002752_abnormal_somatic_nervous | 0.81701077 |
| 127 | MP0000681_abnormal_thyroid_gland | 0.80964172 |
| 128 | MP0003938_abnormal_ear_development | 0.79998572 |
| 129 | MP0005535_abnormal_body_temperature | 0.79813299 |
| 130 | MP0004742_abnormal_vestibular_system | 0.79655863 |
| 131 | MP0002184_abnormal_innervation | 0.79215171 |
| 132 | MP0005376_homeostasis/metabolism_phenot | 0.78684657 |
| 133 | MP0002095_abnormal_skin_pigmentation | 0.78285953 |
| 134 | MP0002067_abnormal_sensory_capabilities | 0.78231954 |
| 135 | MP0002102_abnormal_ear_morphology | 0.78178167 |
| 136 | MP0002733_abnormal_thermal_nociception | 0.77992206 |
| 137 | MP0002723_abnormal_immune_serum | 0.77454152 |
| 138 | MP0002064_seizures | 0.77357698 |
| 139 | MP0000013_abnormal_adipose_tissue | 0.77112321 |
| 140 | MP0005391_vision/eye_phenotype | 0.77107032 |
| 141 | MP0005387_immune_system_phenotype | 0.74728188 |
| 142 | MP0001790_abnormal_immune_system | 0.74728188 |
| 143 | MP0001853_heart_inflammation | 0.74099245 |
| 144 | MP0005171_absent_coat_pigmentation | 0.71322875 |
| 145 | MP0002734_abnormal_mechanical_nocicepti | 0.70428452 |
| 146 | MP0000230_abnormal_systemic_arterial | 0.69961892 |
| 147 | MP0002138_abnormal_hepatobiliary_system | 0.68902509 |
| 148 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.67771588 |
| 149 | MP0009333_abnormal_splenocyte_physiolog | 0.67744441 |
| 150 | MP0003959_abnormal_lean_body | 0.67717714 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 6.38255348 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.78433292 |
| 3 | Mitochondrial inheritance (HP:0001427) | 5.65303923 |
| 4 | Acute encephalopathy (HP:0006846) | 5.38525623 |
| 5 | Progressive macrocephaly (HP:0004481) | 5.37049535 |
| 6 | Increased hepatocellular lipid droplets (HP:0006565) | 4.92649052 |
| 7 | Hepatocellular necrosis (HP:0001404) | 4.76502889 |
| 8 | Increased CSF lactate (HP:0002490) | 4.76076377 |
| 9 | Renal Fanconi syndrome (HP:0001994) | 4.56893304 |
| 10 | Lipid accumulation in hepatocytes (HP:0006561) | 4.51923271 |
| 11 | Hepatic necrosis (HP:0002605) | 4.43503450 |
| 12 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 4.08477899 |
| 13 | 3-Methylglutaconic aciduria (HP:0003535) | 4.08472605 |
| 14 | Cerebral edema (HP:0002181) | 4.05032205 |
| 15 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.81212630 |
| 16 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.81212630 |
| 17 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.78187695 |
| 18 | Increased intramyocellular lipid droplets (HP:0012240) | 3.77143246 |
| 19 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.76316212 |
| 20 | Hypothermia (HP:0002045) | 3.73529296 |
| 21 | Exertional dyspnea (HP:0002875) | 3.63310912 |
| 22 | Optic disc pallor (HP:0000543) | 3.47414834 |
| 23 | Abnormality of renal resorption (HP:0011038) | 3.38822625 |
| 24 | Exercise intolerance (HP:0003546) | 3.37710859 |
| 25 | Lactic acidosis (HP:0003128) | 3.31691539 |
| 26 | Increased muscle lipid content (HP:0009058) | 3.27897311 |
| 27 | Abnormal number of erythroid precursors (HP:0012131) | 3.22472311 |
| 28 | Congenital, generalized hypertrichosis (HP:0004540) | 3.18938942 |
| 29 | Respiratory failure (HP:0002878) | 3.15723773 |
| 30 | Increased serum lactate (HP:0002151) | 3.08425140 |
| 31 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 3.02532882 |
| 32 | Abnormality of urine glucose concentration (HP:0011016) | 2.98150498 |
| 33 | Glycosuria (HP:0003076) | 2.98150498 |
| 34 | Respiratory difficulties (HP:0002880) | 2.87091442 |
| 35 | Leukodystrophy (HP:0002415) | 2.86936177 |
| 36 | Molar tooth sign on MRI (HP:0002419) | 2.83542437 |
| 37 | Abnormality of midbrain morphology (HP:0002418) | 2.83542437 |
| 38 | Hyperphosphaturia (HP:0003109) | 2.82487245 |
| 39 | Medial flaring of the eyebrow (HP:0010747) | 2.81320170 |
| 40 | Macrocytic anemia (HP:0001972) | 2.77560721 |
| 41 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.64446977 |
| 42 | Type I transferrin isoform profile (HP:0003642) | 2.60360456 |
| 43 | Reticulocytopenia (HP:0001896) | 2.56054962 |
| 44 | Nephronophthisis (HP:0000090) | 2.54681249 |
| 45 | Prolonged partial thromboplastin time (HP:0003645) | 2.50377973 |
| 46 | Microvesicular hepatic steatosis (HP:0001414) | 2.48006073 |
| 47 | Septo-optic dysplasia (HP:0100842) | 2.43899401 |
| 48 | Generalized aminoaciduria (HP:0002909) | 2.39336260 |
| 49 | Congenital primary aphakia (HP:0007707) | 2.38356314 |
| 50 | Abnormality of the labia minora (HP:0012880) | 2.33226453 |
| 51 | Abnormality of glycolysis (HP:0004366) | 2.33154994 |
| 52 | Increased serum pyruvate (HP:0003542) | 2.33154994 |
| 53 | Lethargy (HP:0001254) | 2.32763051 |
| 54 | Gait imbalance (HP:0002141) | 2.32043383 |
| 55 | Nephrogenic diabetes insipidus (HP:0009806) | 2.27705532 |
| 56 | Pallor (HP:0000980) | 2.26475889 |
| 57 | Parakeratosis (HP:0001036) | 2.25218670 |
| 58 | Sclerocornea (HP:0000647) | 2.24571573 |
| 59 | Abnormal urine phosphate concentration (HP:0012599) | 2.23088381 |
| 60 | Abnormal hemoglobin (HP:0011902) | 2.19803879 |
| 61 | Renal tubular dysfunction (HP:0000124) | 2.19448696 |
| 62 | Hyperglycinemia (HP:0002154) | 2.14680460 |
| 63 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.11279927 |
| 64 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.11279927 |
| 65 | Abnormal protein glycosylation (HP:0012346) | 2.11279927 |
| 66 | Abnormal glycosylation (HP:0012345) | 2.11279927 |
| 67 | Reduced antithrombin III activity (HP:0001976) | 2.04588390 |
| 68 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.03345895 |
| 69 | Abnormality of the renal medulla (HP:0100957) | 2.03011546 |
| 70 | Colon cancer (HP:0003003) | 2.02350211 |
| 71 | Male pseudohermaphroditism (HP:0000037) | 1.99909741 |
| 72 | CNS demyelination (HP:0007305) | 1.99649901 |
| 73 | Abnormal pupillary function (HP:0007686) | 1.97861607 |
| 74 | X-linked dominant inheritance (HP:0001423) | 1.97028650 |
| 75 | Pendular nystagmus (HP:0012043) | 1.94488344 |
| 76 | Vacuolated lymphocytes (HP:0001922) | 1.93424730 |
| 77 | Abnormality of vitamin B metabolism (HP:0004340) | 1.92398851 |
| 78 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.90239868 |
| 79 | Congenital stationary night blindness (HP:0007642) | 1.88501543 |
| 80 | Abnormality of methionine metabolism (HP:0010901) | 1.88300289 |
| 81 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.84091541 |
| 82 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.83662438 |
| 83 | Optic nerve hypoplasia (HP:0000609) | 1.82893817 |
| 84 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.82887838 |
| 85 | Abnormality of the renal cortex (HP:0011035) | 1.81100917 |
| 86 | Oral leukoplakia (HP:0002745) | 1.80956680 |
| 87 | Anencephaly (HP:0002323) | 1.80038641 |
| 88 | Abnormality of the axillary hair (HP:0100134) | 1.79225489 |
| 89 | Abnormality of secondary sexual hair (HP:0009888) | 1.79225489 |
| 90 | Limb dystonia (HP:0002451) | 1.79097094 |
| 91 | Conjugated hyperbilirubinemia (HP:0002908) | 1.78816280 |
| 92 | Vaginal atresia (HP:0000148) | 1.78718330 |
| 93 | True hermaphroditism (HP:0010459) | 1.78520703 |
| 94 | Methylmalonic aciduria (HP:0012120) | 1.77272722 |
| 95 | Intestinal atresia (HP:0011100) | 1.75675109 |
| 96 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.75044725 |
| 97 | Abnormality of serum amino acid levels (HP:0003112) | 1.73804258 |
| 98 | Abolished electroretinogram (ERG) (HP:0000550) | 1.73670861 |
| 99 | Aplastic anemia (HP:0001915) | 1.73453291 |
| 100 | Symptomatic seizures (HP:0011145) | 1.73280953 |
| 101 | Cystic liver disease (HP:0006706) | 1.71646242 |
| 102 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.70939294 |
| 103 | Genital tract atresia (HP:0001827) | 1.70444531 |
| 104 | Type II lissencephaly (HP:0007260) | 1.69789811 |
| 105 | Absent septum pellucidum (HP:0001331) | 1.69775307 |
| 106 | Congenital ichthyosiform erythroderma (HP:0007431) | 1.69675270 |
| 107 | Abnormal hair whorl (HP:0010721) | 1.66492644 |
| 108 | Large for gestational age (HP:0001520) | 1.66290201 |
| 109 | Hypoglycemic seizures (HP:0002173) | 1.66253116 |
| 110 | Vomiting (HP:0002013) | 1.66042250 |
| 111 | Abnormality of the pons (HP:0007361) | 1.65225917 |
| 112 | Hypoplasia of the pons (HP:0012110) | 1.64118512 |
| 113 | Meckel diverticulum (HP:0002245) | 1.63508184 |
| 114 | Dicarboxylic aciduria (HP:0003215) | 1.63355508 |
| 115 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.63355508 |
| 116 | Furrowed tongue (HP:0000221) | 1.62998204 |
| 117 | Megaloblastic anemia (HP:0001889) | 1.61951778 |
| 118 | Myokymia (HP:0002411) | 1.60752241 |
| 119 | Pancreatic cysts (HP:0001737) | 1.59666563 |
| 120 | Methylmalonic acidemia (HP:0002912) | 1.57225661 |
| 121 | Patchy hypopigmentation of hair (HP:0011365) | 1.57059749 |
| 122 | Amniotic constriction ring (HP:0009775) | 1.55368398 |
| 123 | Abnormality of placental membranes (HP:0011409) | 1.55368398 |
| 124 | Poor coordination (HP:0002370) | 1.54047954 |
| 125 | Hypoglycemic coma (HP:0001325) | 1.53835752 |
| 126 | Proximal tubulopathy (HP:0000114) | 1.53422498 |
| 127 | Gliosis (HP:0002171) | 1.48854550 |
| 128 | Emotional lability (HP:0000712) | 1.46013274 |
| 129 | Neuroendocrine neoplasm (HP:0100634) | 1.45316564 |
| 130 | Pancreatic fibrosis (HP:0100732) | 1.44513908 |
| 131 | Hypoplasia of the uterus (HP:0000013) | 1.44076885 |
| 132 | Hypobetalipoproteinemia (HP:0003563) | 1.43555306 |
| 133 | Renal cortical cysts (HP:0000803) | 1.43351369 |
| 134 | Hypomagnesemia (HP:0002917) | 1.42744466 |
| 135 | Abnormality of magnesium homeostasis (HP:0004921) | 1.41748841 |
| 136 | Blindness (HP:0000618) | 1.41612801 |
| 137 | Congenital sensorineural hearing impairment (HP:0008527) | 1.41544775 |
| 138 | Poor suck (HP:0002033) | 1.40626249 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NME2 | 4.06490190 |
| 2 | VRK2 | 3.77060799 |
| 3 | STK16 | 3.01831283 |
| 4 | MAP3K12 | 2.96690515 |
| 5 | CASK | 2.78395145 |
| 6 | PBK | 2.46255508 |
| 7 | NME1 | 2.38991941 |
| 8 | MST4 | 2.21950409 |
| 9 | VRK1 | 2.19483528 |
| 10 | EIF2AK3 | 2.18766332 |
| 11 | MAPK15 | 1.97916448 |
| 12 | PIM2 | 1.97033563 |
| 13 | CDC7 | 1.94075276 |
| 14 | MAP4K2 | 1.88622994 |
| 15 | ADRBK2 | 1.84758376 |
| 16 | GRK7 | 1.83287425 |
| 17 | GRK5 | 1.71443506 |
| 18 | IRAK4 | 1.70342109 |
| 19 | EIF2AK1 | 1.70193190 |
| 20 | MAP2K7 | 1.67995763 |
| 21 | MYLK | 1.65095124 |
| 22 | MUSK | 1.64056811 |
| 23 | PLK3 | 1.61990770 |
| 24 | IRAK3 | 1.58885896 |
| 25 | TXK | 1.51673954 |
| 26 | TNIK | 1.48074381 |
| 27 | TRIM28 | 1.44038894 |
| 28 | BMPR1B | 1.43574817 |
| 29 | BCKDK | 1.37562545 |
| 30 | MAP3K4 | 1.37198325 |
| 31 | ARAF | 1.35297288 |
| 32 | SRPK1 | 1.34794380 |
| 33 | PINK1 | 1.33760801 |
| 34 | BUB1 | 1.29035180 |
| 35 | PIK3CG | 1.27635768 |
| 36 | INSRR | 1.27410712 |
| 37 | TAF1 | 1.26538931 |
| 38 | TLK1 | 1.24783595 |
| 39 | CSNK1G3 | 1.24226180 |
| 40 | WEE1 | 1.22847288 |
| 41 | FRK | 1.21533260 |
| 42 | WNK4 | 1.21284075 |
| 43 | PNCK | 1.20960298 |
| 44 | TEC | 1.19046788 |
| 45 | PHKG1 | 1.17299017 |
| 46 | PHKG2 | 1.17299017 |
| 47 | NEK1 | 1.12882063 |
| 48 | BRAF | 1.12501429 |
| 49 | MAPKAPK5 | 1.10553706 |
| 50 | BMPR2 | 1.05632835 |
| 51 | STK39 | 1.05548892 |
| 52 | ZAK | 1.00355471 |
| 53 | WNK3 | 0.99833826 |
| 54 | CDK8 | 0.98415969 |
| 55 | PLK1 | 0.96780316 |
| 56 | NLK | 0.95908909 |
| 57 | DYRK2 | 0.95897388 |
| 58 | YES1 | 0.91764008 |
| 59 | BRSK2 | 0.91585609 |
| 60 | IRAK2 | 0.90830098 |
| 61 | PRKCG | 0.90468020 |
| 62 | ABL2 | 0.90003162 |
| 63 | AKT3 | 0.88946091 |
| 64 | IRAK1 | 0.88588644 |
| 65 | KDR | 0.88213910 |
| 66 | PLK2 | 0.88094504 |
| 67 | CSNK1G1 | 0.87703217 |
| 68 | TTK | 0.87464715 |
| 69 | MAP3K14 | 0.85600865 |
| 70 | BCR | 0.84808492 |
| 71 | ERBB3 | 0.84222140 |
| 72 | OXSR1 | 0.84145333 |
| 73 | SIK3 | 0.83792249 |
| 74 | EIF2AK2 | 0.82910122 |
| 75 | CSNK1A1L | 0.81641690 |
| 76 | GRK1 | 0.80818978 |
| 77 | DYRK3 | 0.78864977 |
| 78 | ADRBK1 | 0.78714900 |
| 79 | PASK | 0.76725240 |
| 80 | CSNK1G2 | 0.75586395 |
| 81 | MKNK1 | 0.74998380 |
| 82 | OBSCN | 0.73759493 |
| 83 | ACVR1B | 0.71387451 |
| 84 | PAK3 | 0.70373832 |
| 85 | LYN | 0.69167593 |
| 86 | CDK3 | 0.68277411 |
| 87 | LIMK1 | 0.68201927 |
| 88 | MKNK2 | 0.67619047 |
| 89 | RIPK4 | 0.67086808 |
| 90 | MAP2K2 | 0.66124836 |
| 91 | PLK4 | 0.64578120 |
| 92 | AURKB | 0.63352961 |
| 93 | IKBKB | 0.62115495 |
| 94 | TIE1 | 0.61852830 |
| 95 | MARK1 | 0.61482502 |
| 96 | TGFBR1 | 0.61059006 |
| 97 | TSSK6 | 0.61053471 |
| 98 | MAPK13 | 0.60095181 |
| 99 | CSNK2A1 | 0.59805944 |
| 100 | NEK6 | 0.57774338 |
| 101 | SYK | 0.57410147 |
| 102 | TAOK3 | 0.56787580 |
| 103 | MAPK4 | 0.55666002 |
| 104 | PRKCE | 0.55563794 |
| 105 | IKBKE | 0.53898917 |
| 106 | CAMK2B | 0.53767503 |
| 107 | STK38L | 0.52785346 |
| 108 | CSNK1A1 | 0.51146582 |
| 109 | PDK2 | 0.50007833 |
| 110 | NUAK1 | 0.48370848 |
| 111 | CSNK2A2 | 0.48289234 |
| 112 | TESK2 | 0.48273656 |
| 113 | CDK19 | 0.47914779 |
| 114 | CHEK2 | 0.47847833 |
| 115 | KIT | 0.47816421 |
| 116 | RPS6KA5 | 0.47290382 |
| 117 | STK3 | 0.46199234 |
| 118 | CAMK2D | 0.45326524 |
| 119 | NEK9 | 0.45056106 |
| 120 | MAP3K3 | 0.44826703 |
| 121 | ZAP70 | 0.44219776 |
| 122 | BTK | 0.43746392 |
| 123 | UHMK1 | 0.43161245 |
| 124 | MINK1 | 0.42516352 |
| 125 | CAMK2A | 0.42399748 |
| 126 | PRKACA | 0.42053804 |
| 127 | CAMK2G | 0.41708085 |
| 128 | FES | 0.41600228 |
| 129 | LCK | 0.40973554 |
| 130 | ATR | 0.40770818 |
| 131 | STK4 | 0.39316778 |
| 132 | MST1R | 0.39292623 |
| 133 | NEK2 | 0.39228915 |
| 134 | MAPKAPK3 | 0.39219501 |
| 135 | CSNK1E | 0.38837968 |
| 136 | EPHA4 | 0.38317730 |
| 137 | AURKA | 0.37799903 |
| 138 | PIK3CA | 0.37294576 |
| 139 | CCNB1 | 0.36402308 |
| 140 | PRKCI | 0.35517464 |
| 141 | DAPK1 | 0.35380774 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 5.21722283 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 4.57374614 |
| 3 | Parkinsons disease_Homo sapiens_hsa05012 | 4.39281109 |
| 4 | Protein export_Homo sapiens_hsa03060 | 4.16331487 |
| 5 | Proteasome_Homo sapiens_hsa03050 | 3.52354352 |
| 6 | Alzheimers disease_Homo sapiens_hsa05010 | 3.27145572 |
| 7 | Huntingtons disease_Homo sapiens_hsa05016 | 3.10048328 |
| 8 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.98221802 |
| 9 | RNA polymerase_Homo sapiens_hsa03020 | 2.69474280 |
| 10 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.32691140 |
| 11 | Sulfur metabolism_Homo sapiens_hsa00920 | 2.04226467 |
| 12 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.93947909 |
| 13 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.63270263 |
| 14 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.62448245 |
| 15 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.59289247 |
| 16 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.56058944 |
| 17 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.30973939 |
| 18 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.30806049 |
| 19 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.29421769 |
| 20 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.28767604 |
| 21 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.28377205 |
| 22 | Peroxisome_Homo sapiens_hsa04146 | 1.26791894 |
| 23 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.23649262 |
| 24 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.18656036 |
| 25 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.13869028 |
| 26 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.07752587 |
| 27 | RNA transport_Homo sapiens_hsa03013 | 1.06462811 |
| 28 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.05049052 |
| 29 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.04945574 |
| 30 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.02582999 |
| 31 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.02164817 |
| 32 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.01383740 |
| 33 | Basal transcription factors_Homo sapiens_hsa03022 | 0.99690803 |
| 34 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.98835753 |
| 35 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.97261687 |
| 36 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.96548511 |
| 37 | Histidine metabolism_Homo sapiens_hsa00340 | 0.96496562 |
| 38 | Metabolic pathways_Homo sapiens_hsa01100 | 0.96067603 |
| 39 | Purine metabolism_Homo sapiens_hsa00230 | 0.95761774 |
| 40 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.94339285 |
| 41 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.92584073 |
| 42 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.92478724 |
| 43 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.91516206 |
| 44 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.88417309 |
| 45 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.85166847 |
| 46 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.84586179 |
| 47 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.83534713 |
| 48 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.83293611 |
| 49 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.83196300 |
| 50 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.82898916 |
| 51 | Nicotine addiction_Homo sapiens_hsa05033 | 0.82782154 |
| 52 | Spliceosome_Homo sapiens_hsa03040 | 0.79466249 |
| 53 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.76610456 |
| 54 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.76509088 |
| 55 | Sulfur relay system_Homo sapiens_hsa04122 | 0.75834498 |
| 56 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.75702233 |
| 57 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.75044138 |
| 58 | Phototransduction_Homo sapiens_hsa04744 | 0.74802469 |
| 59 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.74279903 |
| 60 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.73636134 |
| 61 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.72808041 |
| 62 | Retinol metabolism_Homo sapiens_hsa00830 | 0.72610918 |
| 63 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.71034936 |
| 64 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.70685923 |
| 65 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.70453015 |
| 66 | Allograft rejection_Homo sapiens_hsa05330 | 0.69935517 |
| 67 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.69237470 |
| 68 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.69162571 |
| 69 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.66902611 |
| 70 | RNA degradation_Homo sapiens_hsa03018 | 0.66347990 |
| 71 | Homologous recombination_Homo sapiens_hsa03440 | 0.65478558 |
| 72 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.65132067 |
| 73 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.62489349 |
| 74 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.59634640 |
| 75 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.59481069 |
| 76 | Phagosome_Homo sapiens_hsa04145 | 0.59026942 |
| 77 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.58389752 |
| 78 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.58017888 |
| 79 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.56557340 |
| 80 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.53017541 |
| 81 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.50467061 |
| 82 | Asthma_Homo sapiens_hsa05310 | 0.50022629 |
| 83 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.47189935 |
| 84 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.45763315 |
| 85 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.43994500 |
| 86 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.43522052 |
| 87 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.43102831 |
| 88 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.42444083 |
| 89 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.41936991 |
| 90 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.40527322 |
| 91 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.40312614 |
| 92 | Taste transduction_Homo sapiens_hsa04742 | 0.39430818 |
| 93 | Mineral absorption_Homo sapiens_hsa04978 | 0.39258247 |
| 94 | DNA replication_Homo sapiens_hsa03030 | 0.39089794 |
| 95 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.39082550 |
| 96 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.38628401 |
| 97 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.38454906 |
| 98 | Cell cycle_Homo sapiens_hsa04110 | 0.37648780 |
| 99 | Other glycan degradation_Homo sapiens_hsa00511 | 0.37260390 |
| 100 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.37237568 |
| 101 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.36875303 |
| 102 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.36473995 |
| 103 | Olfactory transduction_Homo sapiens_hsa04740 | 0.34889803 |
| 104 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.34590710 |
| 105 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.32785866 |
| 106 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.32547559 |
| 107 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.32169167 |
| 108 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.31111932 |
| 109 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.30457792 |
| 110 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.27710550 |
| 111 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.27600123 |
| 112 | GABAergic synapse_Homo sapiens_hsa04727 | 0.27219148 |
| 113 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.26234430 |
| 114 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.25923327 |
| 115 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.24866950 |
| 116 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.23699058 |
| 117 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.22864153 |
| 118 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.22820675 |
| 119 | Mismatch repair_Homo sapiens_hsa03430 | 0.22621309 |
| 120 | Base excision repair_Homo sapiens_hsa03410 | 0.22449717 |
| 121 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.21999914 |
| 122 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.21324400 |
| 123 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.20294343 |
| 124 | Legionellosis_Homo sapiens_hsa05134 | 0.19650206 |
| 125 | Insulin secretion_Homo sapiens_hsa04911 | 0.19364644 |

