COX17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.71345358
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.60325002
3ATP synthesis coupled proton transport (GO:0015986)7.43453235
4energy coupled proton transport, down electrochemical gradient (GO:0015985)7.43453235
5respiratory electron transport chain (GO:0022904)6.72165397
6electron transport chain (GO:0022900)6.56566688
7ribosomal small subunit biogenesis (GO:0042274)5.65711339
8protein neddylation (GO:0045116)4.57399839
9viral transcription (GO:0019083)4.48844673
10water-soluble vitamin biosynthetic process (GO:0042364)4.34596050
11translational termination (GO:0006415)4.23631533
12establishment of protein localization to mitochondrial membrane (GO:0090151)4.20459375
13cotranslational protein targeting to membrane (GO:0006613)4.05494327
14protein complex biogenesis (GO:0070271)4.04790145
15chaperone-mediated protein transport (GO:0072321)4.04136562
16maturation of SSU-rRNA (GO:0030490)4.03173885
17protein targeting to ER (GO:0045047)4.00919170
18hydrogen ion transmembrane transport (GO:1902600)4.00805689
19central nervous system myelination (GO:0022010)3.96991708
20axon ensheathment in central nervous system (GO:0032291)3.96991708
21SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.94831654
22mitochondrial respiratory chain complex I assembly (GO:0032981)3.93464402
23NADH dehydrogenase complex assembly (GO:0010257)3.93464402
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.93464402
25establishment of protein localization to endoplasmic reticulum (GO:0072599)3.86868787
26protein localization to endoplasmic reticulum (GO:0070972)3.83868826
27presynaptic membrane assembly (GO:0097105)3.83016050
28ATP biosynthetic process (GO:0006754)3.73984245
29purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.72858801
30GTP biosynthetic process (GO:0006183)3.68919746
31nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.68291120
32exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.67590324
33proton transport (GO:0015992)3.66745342
34respiratory chain complex IV assembly (GO:0008535)3.66006081
35DNA deamination (GO:0045006)3.64596563
36purine nucleoside triphosphate biosynthetic process (GO:0009145)3.60408941
37hydrogen transport (GO:0006818)3.57587303
38mitochondrial respiratory chain complex assembly (GO:0033108)3.54808260
39rRNA modification (GO:0000154)3.51004480
40cellular component biogenesis (GO:0044085)3.50787101
41pseudouridine synthesis (GO:0001522)3.50678747
42GPI anchor biosynthetic process (GO:0006506)3.47569557
43presynaptic membrane organization (GO:0097090)3.43493627
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.41637641
45proteasome assembly (GO:0043248)3.35800799
46viral life cycle (GO:0019058)3.35555340
47positive regulation of cellular amine metabolic process (GO:0033240)3.32763220
48positive regulation of action potential (GO:0045760)3.24364955
49cellular protein complex disassembly (GO:0043624)3.23410763
50regulation of pigment cell differentiation (GO:0050932)3.23026214
51protein-cofactor linkage (GO:0018065)3.20828085
52translational elongation (GO:0006414)3.19966422
53positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.19131392
54cytochrome complex assembly (GO:0017004)3.18374041
55regulation of cellular amino acid metabolic process (GO:0006521)3.16212232
56ribonucleoside triphosphate biosynthetic process (GO:0009201)3.15471211
57inner mitochondrial membrane organization (GO:0007007)3.14468624
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.13913926
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.13913926
60platelet dense granule organization (GO:0060155)3.12465183
61negative regulation of protein localization to cell surface (GO:2000009)3.10917500
62negative regulation of ligase activity (GO:0051352)3.08215327
63negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.08215327
64regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.08198547
65rRNA processing (GO:0006364)3.05193299
66GPI anchor metabolic process (GO:0006505)3.05175686
67purine nucleoside monophosphate biosynthetic process (GO:0009127)3.01193948
68purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.01193948
69keratinocyte development (GO:0003334)2.98913036
70postsynaptic membrane organization (GO:0001941)2.96653645
71rRNA metabolic process (GO:0016072)2.96084702
72long-chain fatty acid biosynthetic process (GO:0042759)2.92789432
73neuron cell-cell adhesion (GO:0007158)2.91418063
74pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.90843194
75ribonucleoprotein complex biogenesis (GO:0022613)2.90016702
76DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.89693939
77signal peptide processing (GO:0006465)2.89030372
78regulation of mitochondrial translation (GO:0070129)2.88560031
79UTP biosynthetic process (GO:0006228)2.87428646
80neuronal action potential propagation (GO:0019227)2.87341991
81nuclear-transcribed mRNA catabolic process (GO:0000956)2.85555444
82termination of RNA polymerase III transcription (GO:0006386)2.83506072
83transcription elongation from RNA polymerase III promoter (GO:0006385)2.83506072
84anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.83252439
85intracellular protein transmembrane transport (GO:0065002)2.81314311
86calcium-mediated signaling using intracellular calcium source (GO:0035584)2.81256446
87oxidative phosphorylation (GO:0006119)2.81250137
88translation (GO:0006412)2.81153615
89signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.81134353
90signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.81134353
91signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.81134353
92spliceosomal snRNP assembly (GO:0000387)2.80290358
93ribosomal small subunit assembly (GO:0000028)2.78596115
94organelle disassembly (GO:1903008)2.78427445
95intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.78105888
96signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.78105888
97protein targeting to mitochondrion (GO:0006626)2.77651226
98deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.77427109
99positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.76463235
100rRNA methylation (GO:0031167)2.74687959
101dopamine transport (GO:0015872)2.74340569
102cullin deneddylation (GO:0010388)2.73245261
103ribosomal large subunit biogenesis (GO:0042273)2.72727597
104mannosylation (GO:0097502)2.70900623
105protein transmembrane transport (GO:0071806)2.70786344
106negative regulation of heart rate (GO:0010459)2.70632807
107signal transduction involved in DNA integrity checkpoint (GO:0072401)2.68732291
108signal transduction involved in DNA damage checkpoint (GO:0072422)2.68732291
109mRNA catabolic process (GO:0006402)2.67682712
110translational initiation (GO:0006413)2.66774673
111establishment of protein localization to mitochondrion (GO:0072655)2.66608686
112nucleoside triphosphate biosynthetic process (GO:0009142)2.66418795
113negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.65843985
114regulation of protein kinase A signaling (GO:0010738)2.64650797
115protein targeting to membrane (GO:0006612)2.63456496
116nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.63199189
117nucleoside diphosphate phosphorylation (GO:0006165)2.61892012
118C-terminal protein lipidation (GO:0006501)2.57848488
119developmental pigmentation (GO:0048066)2.53342916
120regulation of oxidative phosphorylation (GO:0002082)2.51610846
121fatty acid elongation (GO:0030497)2.51544577
122negative regulation of execution phase of apoptosis (GO:1900118)2.50923331
123preassembly of GPI anchor in ER membrane (GO:0016254)2.50576902
124regulation of dopamine metabolic process (GO:0042053)2.49231054
125regulation of catecholamine metabolic process (GO:0042069)2.49231054
126short-term memory (GO:0007614)2.49194927
127protein complex disassembly (GO:0043241)2.45077858
128positive regulation of synapse assembly (GO:0051965)2.44207768
129substantia nigra development (GO:0021762)2.42578118
130protein localization to mitochondrion (GO:0070585)2.42538005
131protein localization to cilium (GO:0061512)2.41906037
132response to epinephrine (GO:0071871)2.41459014
133dopamine biosynthetic process (GO:0042416)2.38181989
134regulation of cellular respiration (GO:0043457)2.36823175
135mitochondrial transport (GO:0006839)2.36599998
136aerobic respiration (GO:0009060)2.35781002
137intracellular protein transmembrane import (GO:0044743)2.35283964
138UTP metabolic process (GO:0046051)2.35195717
139macromolecular complex disassembly (GO:0032984)2.34295742
140glycolipid biosynthetic process (GO:0009247)2.33817191
141C-terminal protein amino acid modification (GO:0018410)2.32457988
142negative regulation of synaptic transmission, GABAergic (GO:0032229)2.31454820
143amino sugar catabolic process (GO:0046348)2.29536399
144CTP metabolic process (GO:0046036)2.29399596

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.78367316
2EZH2_22144423_ChIP-Seq_EOC_Human4.67474234
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.81820531
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.51907234
5CREB1_15753290_ChIP-ChIP_HEK293T_Human3.04974167
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.88354218
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.67045124
8VDR_23849224_ChIP-Seq_CD4+_Human2.66597074
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.60586187
10GBX2_23144817_ChIP-Seq_PC3_Human2.57676401
11TAF15_26573619_Chip-Seq_HEK293_Human2.54160568
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.51464253
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.45657633
14VDR_22108803_ChIP-Seq_LS180_Human2.44776615
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.34887746
16FOXP3_21729870_ChIP-Seq_TREG_Human2.28071333
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26335776
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.25419073
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.09577613
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.99910934
21* EST1_17652178_ChIP-ChIP_JURKAT_Human1.93884578
22MYC_18358816_ChIP-ChIP_MESCs_Mouse1.93121099
23IGF1R_20145208_ChIP-Seq_DFB_Human1.93028926
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92046912
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91798162
26THAP11_20581084_ChIP-Seq_MESCs_Mouse1.91571299
27MYC_18940864_ChIP-ChIP_HL60_Human1.87161405
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.83664218
29SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.81027061
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.80076642
31DCP1A_22483619_ChIP-Seq_HELA_Human1.78196495
32IRF1_19129219_ChIP-ChIP_H3396_Human1.78153372
33TTF2_22483619_ChIP-Seq_HELA_Human1.76315976
34* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.74671112
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.74051348
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72289657
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.68722262
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.68004738
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64161716
40SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.63957409
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.61580909
42ZNF274_21170338_ChIP-Seq_K562_Hela1.60307455
43* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58800506
44* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58265729
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.55912758
46FUS_26573619_Chip-Seq_HEK293_Human1.55161680
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.55050862
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54395675
49XRN2_22483619_ChIP-Seq_HELA_Human1.54293812
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52162945
51JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51802481
52P300_19829295_ChIP-Seq_ESCs_Human1.51048294
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50693689
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.49961366
55EWS_26573619_Chip-Seq_HEK293_Human1.49228159
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48314673
57GABP_19822575_ChIP-Seq_HepG2_Human1.47911694
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46625923
59CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46174886
60* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.44619250
61EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.43035528
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42361148
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41863463
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41632053
65ER_23166858_ChIP-Seq_MCF-7_Human1.35255438
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34259959
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33459444
68FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.33295972
69EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31782011
70RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31782011
71RNF2_27304074_Chip-Seq_NSC_Mouse1.31362697
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30323674
73HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30238520
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29453505
75TP53_22573176_ChIP-Seq_HFKS_Human1.27840755
76EZH2_27294783_Chip-Seq_ESCs_Mouse1.26924724
77SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24795590
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24053129
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22454193
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.21691191
81* ETS1_20019798_ChIP-Seq_JURKAT_Human1.21593410
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20005473
83MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19587525
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19385868
85EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.17989339
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17958276
87SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17504001
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16973772
89YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16417828
90P53_22387025_ChIP-Seq_ESCs_Mouse1.15825821
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.15286311
92STAT3_18555785_Chip-Seq_ESCs_Mouse1.14819517
93SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13358881
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.12832203
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.12027609
96RUNX1_27457419_Chip-Seq_LIVER_Mouse1.11985584
97ELK1_22589737_ChIP-Seq_MCF10A_Human1.11572795
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.11466790
99P300_18555785_Chip-Seq_ESCs_Mouse1.10912264
100ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10682340
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10169303
102IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09771988
103SRF_21415370_ChIP-Seq_HL-1_Mouse1.09468811
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09371851
105FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06224172
106FOXA1_25329375_ChIP-Seq_VCAP_Human1.06224172
107CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05585064
108FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05424493
109CMYC_18555785_Chip-Seq_ESCs_Mouse1.04907506
110NMYC_18555785_Chip-Seq_ESCs_Mouse1.04877177
111LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04502109
112SOX2_18555785_Chip-Seq_ESCs_Mouse1.04399483
113STAT1_20625510_ChIP-Seq_HELA_Human1.04260813
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03820844
115UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03471784
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02115037
117TAL1_26923725_Chip-Seq_HPCs_Mouse1.01883972
118E2F1_18555785_Chip-Seq_ESCs_Mouse1.01527699
119KLF4_18555785_Chip-Seq_ESCs_Mouse0.99807960
120POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99222409
121NELFA_20434984_ChIP-Seq_ESCs_Mouse0.98556984
122MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98477307
123SMAD1_18555785_Chip-Seq_ESCs_Mouse0.97409305
124REST_21632747_ChIP-Seq_MESCs_Mouse0.97351363
125SOX2_19829295_ChIP-Seq_ESCs_Human0.97263387
126NANOG_19829295_ChIP-Seq_ESCs_Human0.97263387
127FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97117384
128CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96730367
129MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96432170
130RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95851444
131ERG_20517297_ChIP-Seq_VCAP_Human0.95761457
132AR_20517297_ChIP-Seq_VCAP_Human0.94915575
133OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94577066
134RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93968424
135NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93899465
136FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93582179
137* ELK1_19687146_ChIP-ChIP_HELA_Human0.93046832
138OCT4_18555785_Chip-Seq_ESCs_Mouse0.92746832
139BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92386518
140SOX2_16153702_ChIP-ChIP_HESCs_Human0.91490530
141ZFX_18555785_Chip-Seq_ESCs_Mouse0.90971304
142NCOR_22424771_ChIP-Seq_293T_Human0.90857989
143PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90332294
144ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88778080
145EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88349779
146PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88142589
147GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88025748
148PIAS1_25552417_ChIP-Seq_VCAP_Human0.87744778
149* MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.87481934
150HTT_18923047_ChIP-ChIP_STHdh_Human0.87068611
151YY1_21170310_ChIP-Seq_MESCs_Mouse0.85019676
152PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.82796888
153NANOG_16153702_ChIP-ChIP_HESCs_Human0.82546256
154TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.81076501
155POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.80262575
156RBPJ_21746931_ChIP-Seq_IB4_Human0.78205404
157* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.77609198
158KDM5A_27292631_Chip-Seq_BREAST_Human0.77440938
159* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.74828806

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.95683840
2MP0003136_yellow_coat_color4.61647893
3MP0009379_abnormal_foot_pigmentation4.44735129
4MP0005409_darkened_coat_color3.23037354
5MP0001188_hyperpigmentation3.20538739
6MP0003806_abnormal_nucleotide_metabolis3.01285040
7MP0004381_abnormal_hair_follicle3.01016208
8MP0001529_abnormal_vocalization2.58221399
9MP0006276_abnormal_autonomic_nervous2.52064529
10MP0003186_abnormal_redox_activity2.29760619
11MP0002938_white_spotting2.27815958
12MP0001905_abnormal_dopamine_level2.27801361
13MP0004142_abnormal_muscle_tone2.10500504
14MP0003011_delayed_dark_adaptation2.10320338
15MP0003646_muscle_fatigue2.08740541
16MP0006292_abnormal_olfactory_placode2.04900263
17MP0008877_abnormal_DNA_methylation1.98178524
18MP0001968_abnormal_touch/_nociception1.96537732
19MP0001986_abnormal_taste_sensitivity1.92246016
20MP0002837_dystrophic_cardiac_calcinosis1.85959997
21MP0001440_abnormal_grooming_behavior1.76639277
22MP0003787_abnormal_imprinting1.76245201
23MP0002272_abnormal_nervous_system1.75342648
24MP0008058_abnormal_DNA_repair1.73802874
25MP0000372_irregular_coat_pigmentation1.72792876
26MP0009745_abnormal_behavioral_response1.67010490
27MP0010386_abnormal_urinary_bladder1.64317033
28MP0002735_abnormal_chemical_nociception1.64177996
29MP0009046_muscle_twitch1.64078309
30MP0004145_abnormal_muscle_electrophysio1.63234645
31MP0000920_abnormal_myelination1.60855165
32MP0003786_premature_aging1.60529242
33MP0002736_abnormal_nociception_after1.58791183
34MP0003724_increased_susceptibility_to1.58578180
35MP0005646_abnormal_pituitary_gland1.58013452
36MP0005379_endocrine/exocrine_gland_phen1.54331727
37MP0004270_analgesia1.54290209
38MP0001970_abnormal_pain_threshold1.53182961
39MP0005171_absent_coat_pigmentation1.51802149
40MP0008875_abnormal_xenobiotic_pharmacok1.51016167
41MP0002064_seizures1.49854410
42MP0002638_abnormal_pupillary_reflex1.48185300
43MP0002160_abnormal_reproductive_system1.48000097
44MP0005332_abnormal_amino_acid1.47021852
45MP0008872_abnormal_physiological_respon1.46599356
46MP0002734_abnormal_mechanical_nocicepti1.46400647
47MP0002909_abnormal_adrenal_gland1.45993861
48MP0002163_abnormal_gland_morphology1.45889660
49MP0004742_abnormal_vestibular_system1.42727983
50MP0001486_abnormal_startle_reflex1.42506593
51MP0002693_abnormal_pancreas_physiology1.41358917
52MP0008995_early_reproductive_senescence1.40935332
53MP0000015_abnormal_ear_pigmentation1.39649344
54MP0005174_abnormal_tail_pigmentation1.38513313
55MP0005389_reproductive_system_phenotype1.37001117
56MP0005408_hypopigmentation1.36278263
57MP0002148_abnormal_hypersensitivity_rea1.35579216
58MP0004484_altered_response_of1.35458144
59MP0002876_abnormal_thyroid_physiology1.35327688
60MP0004215_abnormal_myocardial_fiber1.34456685
61MP0006035_abnormal_mitochondrial_morpho1.32186441
62MP0002139_abnormal_hepatobiliary_system1.29850310
63MP0001944_abnormal_pancreas_morphology1.28503583
64MP0000631_abnormal_neuroendocrine_gland1.27640135
65MP0004019_abnormal_vitamin_homeostasis1.25672780
66MP0002572_abnormal_emotion/affect_behav1.24535917
67MP0001919_abnormal_reproductive_system1.24300498
68MP0001501_abnormal_sleep_pattern1.23848892
69MP0003635_abnormal_synaptic_transmissio1.23638804
70MP0002067_abnormal_sensory_capabilities1.23153111
71MP0006072_abnormal_retinal_apoptosis1.18972851
72MP0005165_increased_susceptibility_to1.18056176
73MP0005423_abnormal_somatic_nervous1.17331938
74MP0001764_abnormal_homeostasis1.13821652
75MP0004133_heterotaxia1.13508436
76MP0003693_abnormal_embryo_hatching1.13061007
77MP0002733_abnormal_thermal_nociception1.12996013
78* MP0006036_abnormal_mitochondrial_physio1.11987494
79MP0002277_abnormal_respiratory_mucosa1.08008297
80MP0003879_abnormal_hair_cell1.06615875
81MP0004147_increased_porphyrin_level1.05410497
82MP0008260_abnormal_autophagy1.05264539
83MP0002095_abnormal_skin_pigmentation1.04275669
84MP0003123_paternal_imprinting1.03188244
85MP0003121_genomic_imprinting0.99344687
86MP0001727_abnormal_embryo_implantation0.98770292
87MP0004957_abnormal_blastocyst_morpholog0.98207264
88MP0005551_abnormal_eye_electrophysiolog0.97806345
89MP0003283_abnormal_digestive_organ0.97585525
90MP0002751_abnormal_autonomic_nervous0.96308357
91MP0005451_abnormal_body_composition0.95767995
92MP0002102_abnormal_ear_morphology0.93783692
93MP0009785_altered_susceptibility_to0.93235489
94MP0002332_abnormal_exercise_endurance0.92252946
95MP0001756_abnormal_urination0.92048229
96MP0001485_abnormal_pinna_reflex0.91867631
97MP0003718_maternal_effect0.90854832
98MP0002229_neurodegeneration0.90065876
99MP0005386_behavior/neurological_phenoty0.89337462
100MP0004924_abnormal_behavior0.89337462
101MP0002184_abnormal_innervation0.88222536
102MP0001963_abnormal_hearing_physiology0.87680948
103MP0008789_abnormal_olfactory_epithelium0.87092980
104MP0010094_abnormal_chromosome_stability0.86458331
105MP0005075_abnormal_melanosome_morpholog0.86353002
106MP0005410_abnormal_fertilization0.85795345
107MP0000026_abnormal_inner_ear0.85523570
108MP0003938_abnormal_ear_development0.85264934
109MP0000751_myopathy0.85125560
110MP0002090_abnormal_vision0.84703526
111MP0002557_abnormal_social/conspecific_i0.83894059
112MP0003137_abnormal_impulse_conducting0.82683065
113MP0008569_lethality_at_weaning0.81152958
114MP0000749_muscle_degeneration0.80660295
115MP0005671_abnormal_response_to0.79958839
116MP0005253_abnormal_eye_physiology0.79807604
117MP0002063_abnormal_learning/memory/cond0.79692189
118MP0002210_abnormal_sex_determination0.79499350
119MP0003950_abnormal_plasma_membrane0.77860590
120MP0004043_abnormal_pH_regulation0.76479286
121MP0002653_abnormal_ependyma_morphology0.76444021
122MP0003122_maternal_imprinting0.74842581
123MP0001293_anophthalmia0.74423577
124MP0001664_abnormal_digestion0.74319427
125MP0002752_abnormal_somatic_nervous0.74144095
126MP0005645_abnormal_hypothalamus_physiol0.74075990
127MP0000778_abnormal_nervous_system0.73579119
128MP0003195_calcinosis0.72144577
129MP0005330_cardiomyopathy0.71631700
130MP0002078_abnormal_glucose_homeostasis0.70036821
131MP0009697_abnormal_copulation0.69617551
132MP0004885_abnormal_endolymph0.69478386
133MP0001984_abnormal_olfaction0.69035102
134MP0005195_abnormal_posterior_eye0.68272173
135MP0002822_catalepsy0.67904414
136MP0005000_abnormal_immune_tolerance0.67847846
137MP0005266_abnormal_metabolism0.67224921
138MP0003941_abnormal_skin_development0.66719084
139MP0003953_abnormal_hormone_level0.66121907
140MP0004085_abnormal_heartbeat0.66053565
141MP0005535_abnormal_body_temperature0.65341795
142MP0005084_abnormal_gallbladder_morpholo0.64983279
143MP0005025_abnormal_response_to0.64952394
144MP0000653_abnormal_sex_gland0.64170658
145MP0005636_abnormal_mineral_homeostasis0.64124696
146MP0001502_abnormal_circadian_rhythm0.63994010
147MP0000049_abnormal_middle_ear0.63464562
148MP0001145_abnormal_male_reproductive0.62703466

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.97379557
2Mitochondrial inheritance (HP:0001427)5.49041657
3Abnormal mitochondria in muscle tissue (HP:0008316)5.26850589
4Increased hepatocellular lipid droplets (HP:0006565)5.14668757
5Progressive macrocephaly (HP:0004481)5.01716133
6Acute encephalopathy (HP:0006846)4.74066218
7Hepatocellular necrosis (HP:0001404)4.60488659
8Renal Fanconi syndrome (HP:0001994)4.59404302
9Lipid accumulation in hepatocytes (HP:0006561)4.52743141
10Increased CSF lactate (HP:0002490)4.52497820
11Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.48054825
12Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.06900305
13Abnormality of cells of the erythroid lineage (HP:0012130)3.99730751
14Hepatic necrosis (HP:0002605)3.98593045
153-Methylglutaconic aciduria (HP:0003535)3.92248147
16Increased intramyocellular lipid droplets (HP:0012240)3.79674671
17Optic disc pallor (HP:0000543)3.77104741
18Abnormal number of erythroid precursors (HP:0012131)3.72807695
19Exertional dyspnea (HP:0002875)3.65200787
20Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.48238772
21Parakeratosis (HP:0001036)3.34009850
22Exercise intolerance (HP:0003546)3.23308570
23Increased muscle lipid content (HP:0009058)3.19524162
24Cerebral edema (HP:0002181)3.18054001
25Abnormality of renal resorption (HP:0011038)3.15862101
26Respiratory failure (HP:0002878)3.10176361
27Hypothermia (HP:0002045)3.09843884
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.00524246
29Decreased activity of mitochondrial respiratory chain (HP:0008972)3.00524246
30Congenital, generalized hypertrichosis (HP:0004540)2.94999359
31Methylmalonic aciduria (HP:0012120)2.89654208
32Respiratory difficulties (HP:0002880)2.89642375
33Leukodystrophy (HP:0002415)2.86865455
34Lactic acidosis (HP:0003128)2.84848831
35Abnormal ciliary motility (HP:0012262)2.80839288
36Increased serum lactate (HP:0002151)2.74565202
37Type I transferrin isoform profile (HP:0003642)2.71996572
38Reticulocytopenia (HP:0001896)2.71934690
39Aplastic anemia (HP:0001915)2.68091346
40Macrocytic anemia (HP:0001972)2.64775150
41Abnormality of the axillary hair (HP:0100134)2.54450338
42Abnormality of secondary sexual hair (HP:0009888)2.54450338
43Generalized aminoaciduria (HP:0002909)2.53535272
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.47077515
45Absent/shortened dynein arms (HP:0200106)2.47077515
46Congenital ichthyosiform erythroderma (HP:0007431)2.42660518
47Oral leukoplakia (HP:0002745)2.40191551
48Focal motor seizures (HP:0011153)2.39974640
49Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.38508223
50Abnormal respiratory motile cilium physiology (HP:0012261)2.37572582
51Abnormality of midbrain morphology (HP:0002418)2.37013493
52Molar tooth sign on MRI (HP:0002419)2.37013493
53Aplasia/Hypoplasia of the sacrum (HP:0008517)2.34397359
54Pancreatic cysts (HP:0001737)2.33109322
55Hyperphosphaturia (HP:0003109)2.28074511
56Reduced antithrombin III activity (HP:0001976)2.26517141
57Abnormality of urine glucose concentration (HP:0011016)2.26232389
58Glycosuria (HP:0003076)2.26232389
59Abnormality of aromatic amino acid family metabolism (HP:0004338)2.25836742
60Pallor (HP:0000980)2.24769867
61Sensory axonal neuropathy (HP:0003390)2.24189707
62Abnormal respiratory epithelium morphology (HP:0012253)2.22530951
63Abnormal respiratory motile cilium morphology (HP:0005938)2.22530951
64Muscle hypertrophy of the lower extremities (HP:0008968)2.22477617
65Hypoglycemic coma (HP:0001325)2.21764191
66Abnormality of vitamin B metabolism (HP:0004340)2.19400787
67Pancreatic fibrosis (HP:0100732)2.16557085
68X-linked dominant inheritance (HP:0001423)2.15934313
69Abnormal urine phosphate concentration (HP:0012599)2.13720574
70Renal cortical cysts (HP:0000803)2.08984438
71Dicarboxylic aciduria (HP:0003215)2.08840135
72Abnormality of dicarboxylic acid metabolism (HP:0010995)2.08840135
73Abnormality of methionine metabolism (HP:0010901)2.04781034
74Microvesicular hepatic steatosis (HP:0001414)2.02141567
75Hyperinsulinemic hypoglycemia (HP:0000825)1.96763850
76Thyroid-stimulating hormone excess (HP:0002925)1.96612368
77Retinal dysplasia (HP:0007973)1.95916342
78Calf muscle hypertrophy (HP:0008981)1.95655546
79Increased serum pyruvate (HP:0003542)1.94304673
80Abnormality of glycolysis (HP:0004366)1.94304673
81Abnormal pupillary function (HP:0007686)1.93012288
82Abnormality of aspartate family amino acid metabolism (HP:0010899)1.92719226
83True hermaphroditism (HP:0010459)1.90793296
84Renal tubular dysfunction (HP:0000124)1.85833352
85Nephronophthisis (HP:0000090)1.84685102
86Abnormality of alanine metabolism (HP:0010916)1.83682265
87Hyperalaninemia (HP:0003348)1.83682265
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83682265
89Limb dystonia (HP:0002451)1.81815546
90Absent rod-and cone-mediated responses on ERG (HP:0007688)1.81552098
91Congenital stationary night blindness (HP:0007642)1.81440627
92Abnormality of the renal cortex (HP:0011035)1.80494251
93Concave nail (HP:0001598)1.78096275
94Absent thumb (HP:0009777)1.78056867
95Abnormality of the vitamin B12 metabolism (HP:0004341)1.77601268
96Poor suck (HP:0002033)1.77104238
97Megaloblastic anemia (HP:0001889)1.75712080
98Pancytopenia (HP:0001876)1.75327227
99Duplicated collecting system (HP:0000081)1.75004302
100Ketoacidosis (HP:0001993)1.74329134
101Flat occiput (HP:0005469)1.74046816
102Abnormality of the heme biosynthetic pathway (HP:0010472)1.71359932
103Anhidrosis (HP:0000970)1.70723408
104Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.70517871
105Abnormal protein N-linked glycosylation (HP:0012347)1.70517871
106Abnormal protein glycosylation (HP:0012346)1.70517871
107Abnormal glycosylation (HP:0012345)1.70517871
108Abnormality of serum amino acid levels (HP:0003112)1.69323865
109Large for gestational age (HP:0001520)1.68920557
110Palpitations (HP:0001962)1.68671114
111Paralysis (HP:0003470)1.67964009
112Hyperglycinemia (HP:0002154)1.67953162
113CNS demyelination (HP:0007305)1.67434645
114Abnormality of magnesium homeostasis (HP:0004921)1.66306723
115Attenuation of retinal blood vessels (HP:0007843)1.65284150
116Abnormality of dental color (HP:0011073)1.64930965
117Conjunctival hamartoma (HP:0100780)1.64506787
118Abnormality of placental membranes (HP:0011409)1.64149948
119Amniotic constriction ring (HP:0009775)1.64149948
120Hypomagnesemia (HP:0002917)1.63912847
121Stomatitis (HP:0010280)1.63631209
122Degeneration of anterior horn cells (HP:0002398)1.63119487
123Abnormality of the anterior horn cell (HP:0006802)1.63119487
124Medial flaring of the eyebrow (HP:0010747)1.61310070
125Pendular nystagmus (HP:0012043)1.61258716
126Methylmalonic acidemia (HP:0002912)1.60950109
127Nonprogressive disorder (HP:0003680)1.60854748
128Ketosis (HP:0001946)1.60316596
129Vomiting (HP:0002013)1.60261782
130Abnormal rod and cone electroretinograms (HP:0008323)1.60165871
131Vacuolated lymphocytes (HP:0001922)1.59475427
132Emotional lability (HP:0000712)1.58783183
133Increased IgM level (HP:0003496)1.58554160
134Aplasia/hypoplasia of the uterus (HP:0008684)1.57961378
135Myokymia (HP:0002411)1.57842702
136Blindness (HP:0000618)1.57458573
137Progressive external ophthalmoplegia (HP:0000590)1.55655224
138Testicular atrophy (HP:0000029)1.51988982
139Neuroendocrine neoplasm (HP:0100634)1.50839712
140Lethargy (HP:0001254)1.50403088
141Chronic obstructive pulmonary disease (HP:0006510)1.47676935
142Obstructive lung disease (HP:0006536)1.47676935
143Congenital sensorineural hearing impairment (HP:0008527)1.47370608
144Aplasia cutis congenita (HP:0001057)1.46444341
145Atonic seizures (HP:0010819)1.43996621

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.43989868
2VRK24.01839972
3CASK3.03275343
4NME22.82820488
5ZAK2.75146009
6MUSK2.73918640
7STK162.61880494
8FRK2.53454560
9GRK72.42103481
10STK392.36722839
11MST42.24546351
12MAP3K122.17562069
13PBK2.07623238
14MAP4K22.04495762
15RIPK41.98203297
16PNCK1.94038898
17FGR1.90256506
18NME11.86050186
19BCKDK1.81732006
20IRAK31.79098002
21ARAF1.77009420
22WNK31.74367266
23ADRBK21.72911372
24NUAK11.71869423
25GRK51.69395253
26CDC71.65209051
27MKNK21.65156137
28EIF2AK31.52798653
29IRAK41.52109143
30KDR1.51412866
31EIF2AK11.47148462
32OXSR11.47092909
33MAPKAPK51.44847859
34WNK41.40499676
35MAP2K71.35935847
36CDK191.35411818
37VRK11.33038409
38BMPR21.31848843
39PLK31.26428226
40BMPR1B1.24637671
41NEK11.24629734
42PIM21.23750066
43MYLK1.20983786
44FES1.17388428
45NLK1.16205999
46TAF11.16160381
47IRAK21.16060989
48TLK11.14839158
49MAPK151.12673472
50BCR1.04078972
51NTRK31.04072158
52TRIM281.02835715
53CAMK2B1.01615729
54GRK11.00313282
55EIF2AK20.98112711
56CAMK2D0.95945185
57PKN10.93838610
58BLK0.93534435
59YES10.91392180
60MKNK10.90434055
61EPHA40.88704778
62PDK20.88521662
63OBSCN0.88451439
64CAMK2A0.87724897
65PAK30.86794853
66UHMK10.86741297
67IRAK10.85996885
68PLK10.85781237
69TAOK30.85244583
70PRKCG0.82749542
71CDK80.81166703
72STK240.80070978
73TIE10.79467408
74STK40.79196762
75PRKCI0.78001961
76MAPK130.77891908
77PRPF4B0.77755784
78LIMK10.75424476
79CSNK1G20.74154499
80ACVR1B0.72904289
81PLK40.72804662
82CLK10.72690712
83MAP2K60.72634934
84PASK0.72379478
85MAP3K40.71194282
86TEC0.70536892
87ABL20.68952770
88AURKB0.68311582
89BRAF0.66521182
90CAMK10.65677054
91ILK0.64911928
92PRKCE0.64389931
93MST1R0.64193007
94SRPK10.64154746
95CSNK1G30.62025555
96CSNK2A10.61488573
97STK30.61419145
98ADRBK10.60332613
99AURKA0.58239308
100RPS6KA50.57532363
101CCNB10.56526478
102CDK30.55412108
103BRSK20.55144155
104MAP3K140.55071828
105CAMK2G0.54169909
106LYN0.53785057
107PIK3CG0.51742383
108DYRK30.51614831
109TXK0.51353570
110WNK10.51198340
111EPHB20.49834919
112PRKACA0.49712454
113CSNK1A10.49031768
114STK38L0.48846803
115DYRK20.48323463
116ROCK20.47499545
117PRKCQ0.47103526
118INSRR0.46845194
119TTK0.46352919
120MOS0.44971461
121FGFR20.44543854
122CSNK1G10.43387054
123PHKG20.43378148
124PHKG10.43378148
125CSNK1E0.42433363
126SYK0.42244444
127DAPK20.42002665
128PLK20.40670550
129PRKD20.39065128
130PRKACB0.38770233
131BUB10.37662463
132CHEK20.36661063
133MAPK120.36384398
134DAPK30.36283562
135LCK0.36166024
136PIK3CA0.35918723
137IKBKB0.35431041
138WEE10.35157824
139MAP2K20.34974867
140MAPK40.34868399
141PINK10.33123919
142CSNK2A20.32116747
143GRK60.31729587
144PRKG10.31098860

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.22058885
2Parkinsons disease_Homo sapiens_hsa050125.16736902
3Ribosome_Homo sapiens_hsa030104.39129369
4Alzheimers disease_Homo sapiens_hsa050104.17760719
5Huntingtons disease_Homo sapiens_hsa050163.77893353
6Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.42973089
7Cardiac muscle contraction_Homo sapiens_hsa042602.89851854
8Protein export_Homo sapiens_hsa030602.80294137
9Proteasome_Homo sapiens_hsa030502.32639003
10RNA polymerase_Homo sapiens_hsa030201.90819053
11Fatty acid elongation_Homo sapiens_hsa000621.89741779
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.74891451
13Nicotine addiction_Homo sapiens_hsa050331.71350347
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.70699573
15Collecting duct acid secretion_Homo sapiens_hsa049661.68187820
16Mismatch repair_Homo sapiens_hsa034301.67238289
17Ether lipid metabolism_Homo sapiens_hsa005651.55378084
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48046678
19Folate biosynthesis_Homo sapiens_hsa007901.44619811
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44463003
21Phototransduction_Homo sapiens_hsa047441.32498783
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28666741
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26756101
24Sulfur metabolism_Homo sapiens_hsa009201.25656975
25Rheumatoid arthritis_Homo sapiens_hsa053231.21428538
26Serotonergic synapse_Homo sapiens_hsa047261.18194462
27Graft-versus-host disease_Homo sapiens_hsa053321.18099626
28One carbon pool by folate_Homo sapiens_hsa006701.17614644
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09745338
30Arachidonic acid metabolism_Homo sapiens_hsa005901.09250531
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08322321
32Propanoate metabolism_Homo sapiens_hsa006401.07992017
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07322061
34Butanoate metabolism_Homo sapiens_hsa006501.06293791
35Sphingolipid metabolism_Homo sapiens_hsa006001.05124993
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04842387
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.00344734
38Allograft rejection_Homo sapiens_hsa053300.97344487
39Pyrimidine metabolism_Homo sapiens_hsa002400.96186713
40Autoimmune thyroid disease_Homo sapiens_hsa053200.96047168
41Linoleic acid metabolism_Homo sapiens_hsa005910.95360253
42Tryptophan metabolism_Homo sapiens_hsa003800.93986222
43Vibrio cholerae infection_Homo sapiens_hsa051100.91449975
44Pyruvate metabolism_Homo sapiens_hsa006200.91320317
45Peroxisome_Homo sapiens_hsa041460.90709921
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88887810
47Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88818902
48Asthma_Homo sapiens_hsa053100.86605194
49Taste transduction_Homo sapiens_hsa047420.86159668
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85403106
51Morphine addiction_Homo sapiens_hsa050320.80268615
52Homologous recombination_Homo sapiens_hsa034400.78617601
53Long-term depression_Homo sapiens_hsa047300.76979538
54GABAergic synapse_Homo sapiens_hsa047270.75978046
55RNA transport_Homo sapiens_hsa030130.75468920
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75269987
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75231430
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74866430
59Selenocompound metabolism_Homo sapiens_hsa004500.74796199
60* Metabolic pathways_Homo sapiens_hsa011000.73619403
61Base excision repair_Homo sapiens_hsa034100.72488449
62Chemical carcinogenesis_Homo sapiens_hsa052040.71455732
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70016496
64Glutamatergic synapse_Homo sapiens_hsa047240.69931274
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68100910
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66340259
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65995359
68Steroid biosynthesis_Homo sapiens_hsa001000.65702772
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64634327
70Caffeine metabolism_Homo sapiens_hsa002320.63788025
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61951965
72Other glycan degradation_Homo sapiens_hsa005110.61632546
73Purine metabolism_Homo sapiens_hsa002300.59578661
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57967042
75Sulfur relay system_Homo sapiens_hsa041220.57535678
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57471740
77Calcium signaling pathway_Homo sapiens_hsa040200.56536729
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.56487745
79Fatty acid degradation_Homo sapiens_hsa000710.56283065
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56093115
81Retinol metabolism_Homo sapiens_hsa008300.55532421
82Systemic lupus erythematosus_Homo sapiens_hsa053220.53313117
83Nitrogen metabolism_Homo sapiens_hsa009100.52677729
84Basal transcription factors_Homo sapiens_hsa030220.52425321
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.49184502
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.48766391
87Regulation of autophagy_Homo sapiens_hsa041400.48032941
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.47729173
89Vitamin B6 metabolism_Homo sapiens_hsa007500.46914292
90beta-Alanine metabolism_Homo sapiens_hsa004100.46005327
91Glutathione metabolism_Homo sapiens_hsa004800.45685376
92Vitamin digestion and absorption_Homo sapiens_hsa049770.45659772
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45557850
94African trypanosomiasis_Homo sapiens_hsa051430.45420899
95Fanconi anemia pathway_Homo sapiens_hsa034600.45228228
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.44057495
97Phagosome_Homo sapiens_hsa041450.43559077
98Type I diabetes mellitus_Homo sapiens_hsa049400.43348866
99Hematopoietic cell lineage_Homo sapiens_hsa046400.42584761
100Primary immunodeficiency_Homo sapiens_hsa053400.40991451
101Histidine metabolism_Homo sapiens_hsa003400.40726586
102Synaptic vesicle cycle_Homo sapiens_hsa047210.40008838
103Salivary secretion_Homo sapiens_hsa049700.39894765
104Arginine and proline metabolism_Homo sapiens_hsa003300.39382828
105Amphetamine addiction_Homo sapiens_hsa050310.37153037
106Renin secretion_Homo sapiens_hsa049240.35365118
107Circadian entrainment_Homo sapiens_hsa047130.34670480
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34251693
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.33791155
110Dopaminergic synapse_Homo sapiens_hsa047280.33279204
111Pancreatic secretion_Homo sapiens_hsa049720.31944432
112Nucleotide excision repair_Homo sapiens_hsa034200.29918379
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29590441
114Mineral absorption_Homo sapiens_hsa049780.29037141
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.28333954
116Non-homologous end-joining_Homo sapiens_hsa034500.27942724
117Spliceosome_Homo sapiens_hsa030400.26321029
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.26019585
119Tyrosine metabolism_Homo sapiens_hsa003500.25977993
120Fatty acid metabolism_Homo sapiens_hsa012120.24939933
121Cholinergic synapse_Homo sapiens_hsa047250.24302460
122Long-term potentiation_Homo sapiens_hsa047200.23351898
123Cocaine addiction_Homo sapiens_hsa050300.23032595
124Insulin secretion_Homo sapiens_hsa049110.22766490
125Malaria_Homo sapiens_hsa051440.21684040
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20614542
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.19720267
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19132767
129Ovarian steroidogenesis_Homo sapiens_hsa049130.17827570
130DNA replication_Homo sapiens_hsa030300.17142402
131Pertussis_Homo sapiens_hsa051330.17073546
132Ras signaling pathway_Homo sapiens_hsa040140.17038476
133Axon guidance_Homo sapiens_hsa043600.15740668
134Carbon metabolism_Homo sapiens_hsa012000.15502730
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.14423071
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.14240071
137Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.14166814
138Gastric acid secretion_Homo sapiens_hsa049710.13848233
139RNA degradation_Homo sapiens_hsa030180.13072199

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