COX20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that plays a role in the assembly of cytochrome C oxidase, an important component of the respiratory pathway. It contains two transmembrane helices and localizes to the mitochondrial membrane. Mutations in this gene can cause mitochondrial complex IV deficiency, which results in ataxia and muscle hypotonia. There are multiple pseudogenes for this gene. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.72853863
2energy coupled proton transport, down electrochemical gradient (GO:0015985)8.38747962
3ATP synthesis coupled proton transport (GO:0015986)8.38747962
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)8.09359567
5respiratory electron transport chain (GO:0022904)7.30136183
6electron transport chain (GO:0022900)7.11235612
7ribosomal small subunit biogenesis (GO:0042274)6.34377148
8regulation of skeletal muscle contraction (GO:0014819)6.12737809
9negative regulation of cell aging (GO:0090344)6.06924346
10viral transcription (GO:0019083)6.02229080
11ribosomal small subunit assembly (GO:0000028)5.88283083
12regulation of synapse structural plasticity (GO:0051823)5.85210337
13translational termination (GO:0006415)5.75311099
14protein complex biogenesis (GO:0070271)5.57883202
15mitotic cell cycle arrest (GO:0071850)5.49070500
16DNA strand renaturation (GO:0000733)5.42686585
17cotranslational protein targeting to membrane (GO:0006613)5.41418065
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.36559118
19protein targeting to ER (GO:0045047)5.30416107
20cellular response to ATP (GO:0071318)5.19809058
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.15879651
22mitochondrial respiratory chain complex I assembly (GO:0032981)5.15879651
23NADH dehydrogenase complex assembly (GO:0010257)5.15879651
24detection of light stimulus involved in visual perception (GO:0050908)5.13822854
25detection of light stimulus involved in sensory perception (GO:0050962)5.13822854
26protein localization to endoplasmic reticulum (GO:0070972)5.07724165
27establishment of protein localization to endoplasmic reticulum (GO:0072599)5.04853340
28mitochondrial respiratory chain complex assembly (GO:0033108)4.95795461
29meiotic chromosome segregation (GO:0045132)4.70458088
30transepithelial transport (GO:0070633)4.67680065
31behavioral response to nicotine (GO:0035095)4.67391914
32translational elongation (GO:0006414)4.59337789
33viral life cycle (GO:0019058)4.45887956
34cellular protein complex disassembly (GO:0043624)4.43905690
35chaperone-mediated protein transport (GO:0072321)4.40323212
36rRNA modification (GO:0000154)4.38338451
37respiratory chain complex IV assembly (GO:0008535)4.37879905
38regulation of mitochondrial translation (GO:0070129)4.37423285
39peptidyl-glutamic acid carboxylation (GO:0017187)4.32050691
40protein carboxylation (GO:0018214)4.32050691
41protein neddylation (GO:0045116)4.31818670
42rRNA methylation (GO:0031167)4.30736367
43inner mitochondrial membrane organization (GO:0007007)4.30281136
44GTP biosynthetic process (GO:0006183)4.27921674
45purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.26178147
46ATP biosynthetic process (GO:0006754)4.25679996
47estrogen biosynthetic process (GO:0006703)4.22621770
48cytochrome complex assembly (GO:0017004)4.19767994
49purine nucleoside triphosphate biosynthetic process (GO:0009145)4.19449284
50hydrogen ion transmembrane transport (GO:1902600)4.12869106
51ribosomal large subunit biogenesis (GO:0042273)4.11622117
52nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.94788701
53GDP-mannose metabolic process (GO:0019673)3.92508653
54oxidative phosphorylation (GO:0006119)3.88567893
55regulation of cytokine production involved in inflammatory response (GO:1900015)3.85942348
56proteasome assembly (GO:0043248)3.84221871
57translation (GO:0006412)3.81524329
58lens fiber cell differentiation (GO:0070306)3.78429306
59ribonucleoside triphosphate biosynthetic process (GO:0009201)3.72260274
60proton transport (GO:0015992)3.72103268
61aerobic respiration (GO:0009060)3.67458081
62positive regulation of heat generation (GO:0031652)3.64606027
63hydrogen transport (GO:0006818)3.63262418
64translational initiation (GO:0006413)3.61973757
65maturation of SSU-rRNA (GO:0030490)3.56341934
66protein complex disassembly (GO:0043241)3.53752089
67establishment of protein localization to mitochondrial membrane (GO:0090151)3.49566751
68water-soluble vitamin biosynthetic process (GO:0042364)3.43645735
69protein targeting to membrane (GO:0006612)3.41496739
70UTP biosynthetic process (GO:0006228)3.40313880
71macromolecular complex disassembly (GO:0032984)3.37654325
72regulation of heat generation (GO:0031650)3.25029777
73pseudouridine synthesis (GO:0001522)3.17781230
74protein targeting to mitochondrion (GO:0006626)3.16756514
75DNA replication checkpoint (GO:0000076)3.14777994
76regulation of oxidative phosphorylation (GO:0002082)3.14363040
77nucleoside triphosphate biosynthetic process (GO:0009142)3.12859781
78L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.12465873
79dopamine transport (GO:0015872)3.08701339
80purinergic nucleotide receptor signaling pathway (GO:0035590)3.08349716
81guanosine-containing compound biosynthetic process (GO:1901070)3.04777434
82CTP biosynthetic process (GO:0006241)3.03569849
83CTP metabolic process (GO:0046036)3.03569849
84base-excision repair, AP site formation (GO:0006285)3.01244409
85protein K11-linked ubiquitination (GO:0070979)2.97804414
86preassembly of GPI anchor in ER membrane (GO:0016254)2.97001729
87UTP metabolic process (GO:0046051)2.96986960
88quinone biosynthetic process (GO:1901663)2.94806500
89ubiquinone biosynthetic process (GO:0006744)2.94806500
90establishment of protein localization to mitochondrion (GO:0072655)2.94621562
91cellular component biogenesis (GO:0044085)2.94543092
92regulation of phospholipid biosynthetic process (GO:0071071)2.94463893
93aldehyde catabolic process (GO:0046185)2.93015021
94termination of RNA polymerase III transcription (GO:0006386)2.92972989
95transcription elongation from RNA polymerase III promoter (GO:0006385)2.92972989
96glutathione derivative metabolic process (GO:1901685)2.92067063
97glutathione derivative biosynthetic process (GO:1901687)2.92067063
98GPI anchor biosynthetic process (GO:0006506)2.91590494
99peptidyl-histidine modification (GO:0018202)2.91426307
100protein-cofactor linkage (GO:0018065)2.90988494
101peptidyl-glutamic acid modification (GO:0018200)2.87181476
102mitochondrial transport (GO:0006839)2.83909852
103piRNA metabolic process (GO:0034587)2.83116078
104cilium or flagellum-dependent cell motility (GO:0001539)2.81806396
105protein localization to mitochondrion (GO:0070585)2.80574377
106regulation of nuclear cell cycle DNA replication (GO:0033262)2.78399696
107regulation of cell aging (GO:0090342)2.77365340
108chromatin remodeling at centromere (GO:0031055)2.74030516
109cellular respiration (GO:0045333)2.73803936
110nuclear-transcribed mRNA catabolic process (GO:0000956)2.72570274
111mannosylation (GO:0097502)2.71120504
112spinal cord motor neuron differentiation (GO:0021522)2.68846951
113antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.68712192
114CENP-A containing nucleosome assembly (GO:0034080)2.68330985
115regulation of cellular amino acid metabolic process (GO:0006521)2.67996500
116establishment of viral latency (GO:0019043)2.67610143
117adenosine receptor signaling pathway (GO:0001973)2.67591858
118signal peptide processing (GO:0006465)2.66465835
119kinetochore assembly (GO:0051382)2.65992843
120postsynaptic membrane organization (GO:0001941)2.65864968
121photoreceptor cell development (GO:0042461)2.65673739
122peristalsis (GO:0030432)2.63966726
123sulfur amino acid catabolic process (GO:0000098)2.62696528
124pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.62330794
125nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.60440730
126nucleoside diphosphate phosphorylation (GO:0006165)2.60265402
127granulocyte differentiation (GO:0030851)2.60111330
128nucleotide transmembrane transport (GO:1901679)2.59904887
129response to pheromone (GO:0019236)2.59901930
130urinary tract smooth muscle contraction (GO:0014848)2.59831919
131L-methionine salvage (GO:0071267)2.59697887
132L-methionine biosynthetic process (GO:0071265)2.59697887
133amino acid salvage (GO:0043102)2.59697887
134ubiquinone metabolic process (GO:0006743)2.59373122
135cullin deneddylation (GO:0010388)2.58769882
136mRNA catabolic process (GO:0006402)2.58684627
137RNA capping (GO:0036260)2.58634165
1387-methylguanosine RNA capping (GO:0009452)2.58634165
1397-methylguanosine mRNA capping (GO:0006370)2.58359656
140establishment of integrated proviral latency (GO:0075713)2.57336011
141DNA damage response, detection of DNA damage (GO:0042769)2.57211342
142reciprocal DNA recombination (GO:0035825)2.56128171
143reciprocal meiotic recombination (GO:0007131)2.56128171
144deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.55078933
145neuromuscular synaptic transmission (GO:0007274)2.53569121
146exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.53179249
147dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.52809356
148regulation of cellular respiration (GO:0043457)2.52538298
149antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.52182952
150tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.51855419
151RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.51855419
152intracellular protein transmembrane import (GO:0044743)2.51231373
153G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.51069256
154negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.48344735
155negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.48326308
156DNA deamination (GO:0045006)2.48235686
157regulation of respiratory burst (GO:0060263)2.48030098
158pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.47614255
159metallo-sulfur cluster assembly (GO:0031163)2.47056430
160iron-sulfur cluster assembly (GO:0016226)2.47056430
161protein targeting (GO:0006605)2.46977022
162mitochondrion morphogenesis (GO:0070584)2.45339822
163DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.43765676
164GPI anchor metabolic process (GO:0006505)2.43224936

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.10770286
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.94563650
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.93783366
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.42518298
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.38085089
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.15232590
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.98088267
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.77761117
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.71206738
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.64212707
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.63484593
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.61722251
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.42524116
14CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.37451682
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.31876150
16VDR_22108803_ChIP-Seq_LS180_Human2.30569742
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.28933449
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.24594890
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.14530812
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.11939970
21TP63_19390658_ChIP-ChIP_HaCaT_Human2.11914652
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03316851
23DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.02607170
24CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.00671200
25ELK1_19687146_ChIP-ChIP_HELA_Human1.98521821
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.96630754
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.96380095
28TP53_22573176_ChIP-Seq_HFKS_Human1.84657443
29CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.83467601
30VDR_23849224_ChIP-Seq_CD4+_Human1.82819141
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.81522136
32E2F1_20622854_ChIP-Seq_HELA_Human1.80516776
33GBX2_23144817_ChIP-Seq_PC3_Human1.78504418
34EZH2_22144423_ChIP-Seq_EOC_Human1.78064763
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77931051
36DCP1A_22483619_ChIP-Seq_HELA_Human1.76326633
37FUS_26573619_Chip-Seq_HEK293_Human1.73933219
38P68_20966046_ChIP-Seq_HELA_Human1.73624706
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.73479301
40TAF15_26573619_Chip-Seq_HEK293_Human1.72041929
41IRF1_19129219_ChIP-ChIP_H3396_Human1.68673743
42GABP_19822575_ChIP-Seq_HepG2_Human1.68337353
43FOXP1_21924763_ChIP-Seq_HESCs_Human1.64450856
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59353633
45RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.56259421
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55662798
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55584113
48ZNF274_21170338_ChIP-Seq_K562_Hela1.55210839
49ERA_21632823_ChIP-Seq_H3396_Human1.55192693
50NANOG_20526341_ChIP-Seq_ESCs_Human1.53155242
51CTCF_27219007_Chip-Seq_Bcells_Human1.51418896
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49189296
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48481649
54TTF2_22483619_ChIP-Seq_HELA_Human1.48159865
55FOXP3_21729870_ChIP-Seq_TREG_Human1.47180645
56MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.46636679
57CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.43199067
58RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.43072997
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.42165721
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41959740
61YY1_22570637_ChIP-Seq_MALME-3M_Human1.40723082
62PHF8_20622854_ChIP-Seq_HELA_Human1.40330560
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39985725
64EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.38778202
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.38568296
66MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38559899
67MYC_18940864_ChIP-ChIP_HL60_Human1.38281547
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38212014
69CTCF_20526341_ChIP-Seq_ESCs_Human1.37917614
70VDR_21846776_ChIP-Seq_THP-1_Human1.36243824
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.33583951
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.31820129
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31702529
74BCL6_27268052_Chip-Seq_Bcells_Human1.31687207
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.30816596
76MYC_19829295_ChIP-Seq_ESCs_Human1.30595727
77IGF1R_20145208_ChIP-Seq_DFB_Human1.29392040
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.28929484
79RXRA_24833708_ChIP-Seq_LIVER_Mouse1.27691187
80P53_21459846_ChIP-Seq_SAOS-2_Human1.26932847
81E2F4_17652178_ChIP-ChIP_JURKAT_Human1.26431133
82YY1_21170310_ChIP-Seq_MESCs_Mouse1.25224004
83E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24181605
84TAF2_19829295_ChIP-Seq_ESCs_Human1.21932378
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21154571
86RARB_24833708_ChIP-Seq_LIVER_Mouse1.19908557
87MAF_26560356_Chip-Seq_TH2_Human1.19535666
88RARA_24833708_ChIP-Seq_LIVER_Mouse1.18965388
89P300_19829295_ChIP-Seq_ESCs_Human1.18793511
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18616978
91EWS_26573619_Chip-Seq_HEK293_Human1.18431749
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17669844
93THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17582555
94EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.17377205
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.16707251
96ER_23166858_ChIP-Seq_MCF-7_Human1.15910396
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15708167
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15493221
99CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13077164
100BCOR_27268052_Chip-Seq_Bcells_Human1.12852194
101EZH2_27304074_Chip-Seq_ESCs_Mouse1.11439254
102EZH2_27294783_Chip-Seq_NPCs_Mouse1.10724375
103LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10503560
104STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10427416
105RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10415288
106SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09444436
107HTT_18923047_ChIP-ChIP_STHdh_Human1.09351006
108CTCF_21964334_Chip-Seq_Bcells_Human1.07055689
109OCT4_20526341_ChIP-Seq_ESCs_Human1.06991963
110SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.06757943
111MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06721000
112EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03360844
113ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02953856
114TAL1_26923725_Chip-Seq_HPCs_Mouse1.02486566
115SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02093326
116SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01815112
117XRN2_22483619_ChIP-Seq_HELA_Human1.01681161
118TET1_21451524_ChIP-Seq_MESCs_Mouse1.01650343
119PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01634341
120NCOR_22424771_ChIP-Seq_293T_Human1.01527676
121TDRD3_21172665_ChIP-Seq_MCF-7_Human1.00321077
122NFE2_27457419_Chip-Seq_LIVER_Mouse1.00058100
123PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99513672
124STAT3_18555785_Chip-Seq_ESCs_Mouse0.99393147
125P53_22387025_ChIP-Seq_ESCs_Mouse0.99092929
126IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99067494
127RNF2_27304074_Chip-Seq_NSC_Mouse0.98966214
128MYC_19030024_ChIP-ChIP_MESCs_Mouse0.97676367
129HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96349764
130EZH2_27294783_Chip-Seq_ESCs_Mouse0.95836775
131FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95064750
132JARID2_20064375_ChIP-Seq_MESCs_Mouse0.94734723
133POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94272868
134EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.94264241
135NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94179533
136ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93306636
137SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93158747
138EED_16625203_ChIP-ChIP_MESCs_Mouse0.91824178
139SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91617197
140MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91146664
141GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90723944
142PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.90706466
143POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.90638950
144ERG_20517297_ChIP-Seq_VCAP_Human0.89353636
145NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.89121506
146NMYC_18555785_Chip-Seq_ESCs_Mouse0.87901044
147TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.87285270
148CRX_20693478_ChIP-Seq_RETINA_Mouse0.87225275
149GATA3_21878914_ChIP-Seq_MCF-7_Human0.86986241
150PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86610887
151RUNX1_27457419_Chip-Seq_LIVER_Mouse0.86091910
152P300_18555785_Chip-Seq_ESCs_Mouse0.85093265
153EGR1_23403033_ChIP-Seq_LIVER_Mouse0.84218124
154NANOG_18555785_Chip-Seq_ESCs_Mouse0.83979325
155CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83035650
156SOX2_18555785_Chip-Seq_ESCs_Mouse0.81664737
157UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81430516
158ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.80516027

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.78497426
2MP0001529_abnormal_vocalization3.44380208
3MP0003880_abnormal_central_pattern3.01570044
4MP0003136_yellow_coat_color2.96726562
5MP0002132_abnormal_respiratory_system2.80122003
6MP0002638_abnormal_pupillary_reflex2.71530127
7MP0004381_abnormal_hair_follicle2.60591675
8MP0002160_abnormal_reproductive_system2.59577695
9MP0006276_abnormal_autonomic_nervous2.39011261
10MP0001905_abnormal_dopamine_level2.37527938
11MP0005409_darkened_coat_color2.36228666
12MP0003011_delayed_dark_adaptation2.35763112
13MP0003724_increased_susceptibility_to2.31252898
14MP0006292_abnormal_olfactory_placode2.27590684
15MP0001188_hyperpigmentation2.26770521
16MP0004147_increased_porphyrin_level2.08529962
17MP0000372_irregular_coat_pigmentation2.05464597
18MP0006036_abnormal_mitochondrial_physio1.90938777
19MP0001756_abnormal_urination1.90085387
20MP0005083_abnormal_biliary_tract1.84488709
21MP0003806_abnormal_nucleotide_metabolis1.82673223
22MP0002277_abnormal_respiratory_mucosa1.81951489
23MP0001986_abnormal_taste_sensitivity1.77762783
24MP0005171_absent_coat_pigmentation1.76106997
25MP0001502_abnormal_circadian_rhythm1.76081746
26MP0009697_abnormal_copulation1.75528734
27MP0000566_synostosis1.74503479
28MP0002938_white_spotting1.70119576
29MP0002102_abnormal_ear_morphology1.68121624
30MP0003186_abnormal_redox_activity1.67904860
31MP0005410_abnormal_fertilization1.66025440
32MP0001919_abnormal_reproductive_system1.64676786
33MP0002876_abnormal_thyroid_physiology1.63152831
34MP0002163_abnormal_gland_morphology1.62827024
35MP0005646_abnormal_pituitary_gland1.58558900
36MP0009785_altered_susceptibility_to1.53171596
37MP0010386_abnormal_urinary_bladder1.52293217
38MP0002837_dystrophic_cardiac_calcinosis1.51785093
39MP0005332_abnormal_amino_acid1.51695167
40MP0000751_myopathy1.49567535
41MP0005379_endocrine/exocrine_gland_phen1.49250066
42MP0006035_abnormal_mitochondrial_morpho1.49132841
43MP0005389_reproductive_system_phenotype1.48465911
44MP0001661_extended_life_span1.46670256
45MP0002148_abnormal_hypersensitivity_rea1.45985285
46MP0004215_abnormal_myocardial_fiber1.45277625
47MP0005084_abnormal_gallbladder_morpholo1.44354875
48MP0001984_abnormal_olfaction1.43765920
49MP0005075_abnormal_melanosome_morpholog1.43442928
50MP0005330_cardiomyopathy1.42892618
51MP0002736_abnormal_nociception_after1.40228558
52MP0005174_abnormal_tail_pigmentation1.39555915
53MP0006072_abnormal_retinal_apoptosis1.39053246
54MP0005551_abnormal_eye_electrophysiolog1.37833870
55MP0005377_hearing/vestibular/ear_phenot1.36030325
56MP0003878_abnormal_ear_physiology1.36030325
57MP0005408_hypopigmentation1.33450750
58MP0008058_abnormal_DNA_repair1.30787650
59MP0000750_abnormal_muscle_regeneration1.24949525
60MP0005636_abnormal_mineral_homeostasis1.22909486
61MP0004742_abnormal_vestibular_system1.20024947
62MP0004142_abnormal_muscle_tone1.17378446
63MP0001324_abnormal_eye_pigmentation1.16096733
64MP0005253_abnormal_eye_physiology1.15433175
65MP0005423_abnormal_somatic_nervous1.14842803
66MP0002009_preneoplasia1.12803295
67MP0001764_abnormal_homeostasis1.10618271
68MP0000026_abnormal_inner_ear1.10513220
69MP0001968_abnormal_touch/_nociception1.09307836
70MP0005671_abnormal_response_to1.08353421
71MP0002272_abnormal_nervous_system1.06909761
72MP0001485_abnormal_pinna_reflex1.06326292
73MP0001486_abnormal_startle_reflex1.05323680
74MP0008004_abnormal_stomach_pH1.04723125
75MP0005645_abnormal_hypothalamus_physiol1.03980168
76MP0001835_abnormal_antigen_presentation1.02289627
77MP0004130_abnormal_muscle_cell1.02076787
78MP0003137_abnormal_impulse_conducting1.01853303
79MP0000538_abnormal_urinary_bladder0.99536877
80MP0002909_abnormal_adrenal_gland0.97947654
81MP0001440_abnormal_grooming_behavior0.97673748
82MP0003718_maternal_effect0.97324751
83MP0009745_abnormal_behavioral_response0.95577526
84MP0002928_abnormal_bile_duct0.94752988
85MP0003635_abnormal_synaptic_transmissio0.94712414
86MP0000778_abnormal_nervous_system0.94628317
87MP0004885_abnormal_endolymph0.92590966
88MP0004043_abnormal_pH_regulation0.92554814
89MP0002210_abnormal_sex_determination0.92450053
90MP0000049_abnormal_middle_ear0.92272174
91MP0001664_abnormal_digestion0.92199331
92MP0008872_abnormal_physiological_respon0.91692214
93MP0005386_behavior/neurological_phenoty0.91399313
94MP0004924_abnormal_behavior0.91399313
95MP0005025_abnormal_response_to0.91203880
96MP0008789_abnormal_olfactory_epithelium0.90063219
97MP0008875_abnormal_xenobiotic_pharmacok0.88936022
98MP0000631_abnormal_neuroendocrine_gland0.88081513
99MP0005195_abnormal_posterior_eye0.87872229
100MP0004145_abnormal_muscle_electrophysio0.87620153
101MP0003315_abnormal_perineum_morphology0.85017822
102MP0003938_abnormal_ear_development0.84770453
103MP0001963_abnormal_hearing_physiology0.82861166
104MP0003195_calcinosis0.80928692
105MP0004782_abnormal_surfactant_physiolog0.80074446
106MP0001501_abnormal_sleep_pattern0.79652194
107MP0002063_abnormal_learning/memory/cond0.77211797
108MP0000749_muscle_degeneration0.77174489
109MP0005391_vision/eye_phenotype0.76997840
110MP0003698_abnormal_male_reproductive0.76263598
111MP0002090_abnormal_vision0.76094028
112MP0002752_abnormal_somatic_nervous0.75481887
113MP0003646_muscle_fatigue0.73659415
114MP0002572_abnormal_emotion/affect_behav0.73384136
115MP0002067_abnormal_sensory_capabilities0.73330651
116MP0001929_abnormal_gametogenesis0.72963458
117MP0002734_abnormal_mechanical_nocicepti0.72551686
118MP0004957_abnormal_blastocyst_morpholog0.72175011
119MP0004019_abnormal_vitamin_homeostasis0.71878227
120MP0003111_abnormal_nucleus_morphology0.71333852
121MP0000230_abnormal_systemic_arterial0.71242436
122MP0002064_seizures0.71150326
123MP0003077_abnormal_cell_cycle0.71091631
124MP0001293_anophthalmia0.70837725
125MP0004133_heterotaxia0.70812913
126MP0002735_abnormal_chemical_nociception0.70209903
127MP0005000_abnormal_immune_tolerance0.69716323
128MP0000015_abnormal_ear_pigmentation0.69527368
129MP0002751_abnormal_autonomic_nervous0.69201061
130MP0001853_heart_inflammation0.67988057
131MP0003763_abnormal_thymus_physiology0.66667270
132MP0004484_altered_response_of0.66305573
133MP0001663_abnormal_digestive_system0.65376822
134MP0001145_abnormal_male_reproductive0.63676358
135MP0002095_abnormal_skin_pigmentation0.63588668
136MP0001765_abnormal_ion_homeostasis0.61830413
137MP0009046_muscle_twitch0.59987323
138MP0005165_increased_susceptibility_to0.59927791
139MP0005451_abnormal_body_composition0.59738369
140MP0002822_catalepsy0.58544119
141MP0001970_abnormal_pain_threshold0.57736176
142MP0003828_pulmonary_edema0.56873985
143MP0002557_abnormal_social/conspecific_i0.56310564
144MP0009384_cardiac_valve_regurgitation0.55799249

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.87259732
2Abnormal mitochondria in muscle tissue (HP:0008316)6.28393386
3Rib fusion (HP:0000902)6.05893116
4* Mitochondrial inheritance (HP:0001427)5.94321119
5Progressive macrocephaly (HP:0004481)5.83628622
6Acute encephalopathy (HP:0006846)5.65030441
7Testicular atrophy (HP:0000029)5.63186003
8Dyschromatopsia (HP:0007641)5.24161844
9Hepatocellular necrosis (HP:0001404)5.18462929
10Attenuation of retinal blood vessels (HP:0007843)5.06032747
11* Increased CSF lactate (HP:0002490)4.97470943
12Hepatic necrosis (HP:0002605)4.80576250
13Mesangial abnormality (HP:0001966)4.74208667
14Abnormality of cells of the erythroid lineage (HP:0012130)4.58166754
15* Increased hepatocellular lipid droplets (HP:0006565)4.47928037
16Abnormal number of erythroid precursors (HP:0012131)4.33699605
17Congenital stationary night blindness (HP:0007642)4.23425990
18* Renal Fanconi syndrome (HP:0001994)4.23005133
19Decreased activity of mitochondrial respiratory chain (HP:0008972)4.22191381
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.22191381
21Reticulocytopenia (HP:0001896)4.20804854
22Cerebral edema (HP:0002181)4.01042281
233-Methylglutaconic aciduria (HP:0003535)3.97839397
24* Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.95400055
25* Lipid accumulation in hepatocytes (HP:0006561)3.94033218
26Rectal fistula (HP:0100590)3.92367627
27Rectovaginal fistula (HP:0000143)3.92367627
28Decreased central vision (HP:0007663)3.88548353
29Optic disc pallor (HP:0000543)3.77261111
30Prolonged partial thromboplastin time (HP:0003645)3.74998405
31Choroideremia (HP:0001139)3.66819051
32Decreased electroretinogram (ERG) amplitude (HP:0000654)3.64484578
33Facial diplegia (HP:0001349)3.63928778
34* Exercise intolerance (HP:0003546)3.58770323
35* Increased intramyocellular lipid droplets (HP:0012240)3.50736211
36Abnormality of the intrinsic pathway (HP:0010989)3.46788755
37* Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.43620721
38* Lactic acidosis (HP:0003128)3.42994411
39Bony spicule pigmentary retinopathy (HP:0007737)3.37262431
40Respiratory failure (HP:0002878)3.35335958
41Akinesia (HP:0002304)3.35130538
42Myotonia (HP:0002486)3.35100938
43* Increased serum lactate (HP:0002151)3.30240542
44Facial hemangioma (HP:0000329)3.29217907
45Vaginal fistula (HP:0004320)3.23650640
46Intestinal fistula (HP:0100819)3.22716753
47Fetal akinesia sequence (HP:0001989)3.16276168
48Popliteal pterygium (HP:0009756)3.12112934
49Poikiloderma (HP:0001029)3.11325227
50Pallor (HP:0000980)3.09838764
51Leukodystrophy (HP:0002415)3.09426785
52Hypoalbuminemia (HP:0003073)3.07692741
53Abnormal albumin level (HP:0012116)3.07692741
54Joint hemorrhage (HP:0005261)3.06718133
55Macrocytic anemia (HP:0001972)3.05406148
56Patellar aplasia (HP:0006443)2.98307026
57Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.93211857
58* Increased muscle lipid content (HP:0009058)2.90707965
59Chorioretinal atrophy (HP:0000533)2.89229321
60Aplasia of the musculature (HP:0100854)2.87335105
61* Exertional dyspnea (HP:0002875)2.86699389
62* Abnormality of renal resorption (HP:0011038)2.83323294
63Absent thumb (HP:0009777)2.83241861
64* Respiratory difficulties (HP:0002880)2.80503839
65Aplasia/Hypoplasia of the patella (HP:0006498)2.80139769
66Coronal craniosynostosis (HP:0004440)2.68254681
67Abnormality of glycolysis (HP:0004366)2.67936716
68Increased serum pyruvate (HP:0003542)2.67936716
69Hypothermia (HP:0002045)2.66622349
70* Glycosuria (HP:0003076)2.64718833
71* Abnormality of urine glucose concentration (HP:0011016)2.64718833
72Aplasia/Hypoplasia of the sacrum (HP:0008517)2.63248201
73Molar tooth sign on MRI (HP:0002419)2.58284245
74Abnormality of midbrain morphology (HP:0002418)2.58284245
75Polydipsia (HP:0001959)2.57195026
76Abnormal drinking behavior (HP:0030082)2.57195026
77Annular pancreas (HP:0001734)2.53269023
78Type I transferrin isoform profile (HP:0003642)2.51649998
79Congenital, generalized hypertrichosis (HP:0004540)2.44627412
80Short chin (HP:0000331)2.43395741
81Parakeratosis (HP:0001036)2.42543013
82Birth length less than 3rd percentile (HP:0003561)2.41141595
83Hypophosphatemic rickets (HP:0004912)2.39133242
84Atrioventricular block (HP:0001678)2.37969771
85Abnormality of the heme biosynthetic pathway (HP:0010472)2.36873077
86Squamous cell carcinoma (HP:0002860)2.36678359
87Pendular nystagmus (HP:0012043)2.35506132
88Aplasia/Hypoplasia involving the musculature (HP:0001460)2.34768058
89Abnormality of secondary sexual hair (HP:0009888)2.33988434
90Abnormality of the axillary hair (HP:0100134)2.33988434
91X-linked dominant inheritance (HP:0001423)2.33688365
92Neonatal respiratory distress (HP:0002643)2.33328873
93Turricephaly (HP:0000262)2.30823016
94Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.30256193
95Generalized aminoaciduria (HP:0002909)2.29082126
96* Renal tubular dysfunction (HP:0000124)2.28082444
97Hemorrhage of the eye (HP:0011885)2.19720875
98Pancreatic fibrosis (HP:0100732)2.18686808
99Pancreatic cysts (HP:0001737)2.18054024
100Delayed epiphyseal ossification (HP:0002663)2.17869600
101Hypoplasia of the pons (HP:0012110)2.16281006
102Abnormality of placental membranes (HP:0011409)2.12451633
103Amniotic constriction ring (HP:0009775)2.12451633
104Neonatal onset (HP:0003623)2.11870631
105Lethargy (HP:0001254)2.10470335
106Congenital sensorineural hearing impairment (HP:0008527)2.10408914
107Microvesicular hepatic steatosis (HP:0001414)2.08972208
108Methylmalonic acidemia (HP:0002912)2.07743597
109Zonular cataract (HP:0010920)2.07029684
110Abnormality of the pons (HP:0007361)2.03161656
111Thin bony cortex (HP:0002753)2.00033582
112Enlarged epiphyses (HP:0010580)1.99128346
113Medial flaring of the eyebrow (HP:0010747)1.98882371
114Abnormal ciliary motility (HP:0012262)1.98438949
115Polyuria (HP:0000103)1.97668999
116Abnormal hemoglobin (HP:0011902)1.97641381
117Nephronophthisis (HP:0000090)1.96976247
118Small hand (HP:0200055)1.95777235
119Type 2 muscle fiber atrophy (HP:0003554)1.91371446
120Abnormal respiratory motile cilium morphology (HP:0005938)1.90814354
121Abnormal respiratory epithelium morphology (HP:0012253)1.90814354
122Nephrogenic diabetes insipidus (HP:0009806)1.90543740
123Abnormality of the costochondral junction (HP:0000919)1.90128926
124Anteriorly placed anus (HP:0001545)1.88016436
125Respiratory distress (HP:0002098)1.87717512
126Abnormality of alanine metabolism (HP:0010916)1.87353498
127Hyperalaninemia (HP:0003348)1.87353498
128Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87353498
129Methylmalonic aciduria (HP:0012120)1.86361433
130Patchy hypopigmentation of hair (HP:0011365)1.86154436
131Abnormal epiphyseal ossification (HP:0010656)1.83707039
132* Hyperphosphaturia (HP:0003109)1.82619674
133Renal cortical cysts (HP:0000803)1.82551261
134Abnormal rod and cone electroretinograms (HP:0008323)1.82524293
135Long clavicles (HP:0000890)1.82430519
136Neuroendocrine neoplasm (HP:0100634)1.82193541
137Aplasia/Hypoplasia of the lens (HP:0008063)1.81109973
138Abnormal pupillary function (HP:0007686)1.81053545
139CNS demyelination (HP:0007305)1.80370301
140Epiphyseal stippling (HP:0010655)1.79214700
141Macular degeneration (HP:0000608)1.75579922
142Chronic hepatic failure (HP:0100626)1.75320974
143Diminished movement (HP:0002374)1.74941215
144Premature graying of hair (HP:0002216)1.73185490
145Hypoplasia of the radius (HP:0002984)1.72832612
146Aplasia/hypoplasia of the uterus (HP:0008684)1.72791085
147Ulnar bowing (HP:0003031)1.72275701
148Abnormal protein glycosylation (HP:0012346)1.72163927
149Abnormal glycosylation (HP:0012345)1.72163927
150Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.72163927
151Abnormal protein N-linked glycosylation (HP:0012347)1.72163927
152Aplastic anemia (HP:0001915)1.71340337
153Vomiting (HP:0002013)1.70913044
154Hypoplastic left heart (HP:0004383)1.70349906
155True hermaphroditism (HP:0010459)1.69509071
156Partial duplication of thumb phalanx (HP:0009944)1.69479432
157Conjugated hyperbilirubinemia (HP:0002908)1.69357543
158Abnormal urine output (HP:0012590)1.67665618
159Heart block (HP:0012722)1.66307593
160Dicarboxylic aciduria (HP:0003215)1.66256814
161Abnormality of dicarboxylic acid metabolism (HP:0010995)1.66256814
162Congenital ichthyosiform erythroderma (HP:0007431)1.65622286
163Congenital primary aphakia (HP:0007707)1.63314250
164Absent/shortened dynein arms (HP:0200106)1.60582359
165Dynein arm defect of respiratory motile cilia (HP:0012255)1.60582359
166Gait imbalance (HP:0002141)1.58176921
167Blindness (HP:0000618)1.57022059
168Increased IgM level (HP:0003496)1.56946864
169Reduced antithrombin III activity (HP:0001976)1.56082546
170White forelock (HP:0002211)1.55768760
171Emotional lability (HP:0000712)1.55576186
172Gliosis (HP:0002171)1.51849029
173Nasolacrimal duct obstruction (HP:0000579)1.51624358
174Hypoplasia of the uterus (HP:0000013)1.48847906
175Duplicated collecting system (HP:0000081)1.48607494
176* Abnormal urine phosphate concentration (HP:0012599)1.48502812
177Progressive external ophthalmoplegia (HP:0000590)1.47615046

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.57257305
2NME13.10224635
3PBK3.05553968
4CASK2.94980064
5STK162.86206511
6TNIK2.69510327
7MUSK2.60913132
8VRK12.37702568
9MST42.33651026
10MAP3K122.32367581
11MYLK2.17177125
12GRK72.10567229
13STK392.00121819
14TRIM281.94733327
15PINK11.92007678
16TLK11.89363508
17IRAK41.84058859
18BUB11.78811498
19BMPR1B1.72113094
20TXK1.64315913
21MAP4K21.60876405
22WNK41.58400081
23ADRBK21.56526836
24ACVR1B1.54619927
25VRK21.51777397
26BMPR21.48862753
27TEC1.46076182
28TIE11.33385382
29OXSR11.30170264
30BCR1.28867359
31IRAK31.28475210
32NUAK11.24124717
33MAP2K71.23676646
34PIM21.19457931
35MARK11.18650671
36INSRR1.17224270
37IRAK21.15088013
38NEK21.06751110
39EIF2AK31.06639563
40GRK11.06080760
41PHKG21.06056019
42PHKG11.06056019
43ZAK1.04412189
44OBSCN1.04192746
45EIF2AK11.03397127
46MAPK150.99218068
47EIF2AK20.99194303
48PLK10.97029220
49BCKDK0.92780162
50DYRK30.92641733
51BRSK20.90392395
52SIK20.90383224
53FRK0.89897973
54DYRK20.89000669
55YES10.88712580
56MAPK130.87725402
57CDK190.86804443
58EPHB20.86685546
59FES0.84198087
60MAPKAPK50.82836987
61PRKCG0.79740438
62MKNK20.79593899
63CDC70.78060412
64CSNK1G20.77510056
65CAMK2B0.77468127
66CDK80.75287603
67MAP3K40.74974160
68CAMK2D0.73711690
69MKNK10.71939580
70SRPK10.71288332
71CAMK2A0.71176601
72CSNK1G30.70992404
73PRKCE0.68980875
74IKBKE0.68411901
75SIK30.68316238
76PIK3CG0.68027810
77CDK30.67536644
78PDK20.67284254
79LYN0.65662272
80CDK150.64650683
81GRK50.64084409
82SYK0.63689367
83CDK180.63398151
84PLK30.62460806
85ABL20.62126982
86CSNK1G10.61148934
87STK240.61057465
88IRAK10.60680781
89RPS6KA50.60662080
90UHMK10.60474406
91CDK11A0.60368758
92PAK30.60173583
93TGFBR10.60004340
94MAP2K60.59640966
95CCNB10.59455578
96MINK10.59114599
97MAP3K110.58676597
98ADRBK10.58441164
99CSNK1A1L0.57682253
100MAP3K140.57549798
101CSNK2A10.57430746
102CDK140.57356733
103PIK3CA0.56021974
104CHEK20.55527588
105PKN10.55279423
106AURKA0.55240097
107BLK0.54992291
108MAPK40.54859623
109WNK10.54378475
110KIT0.54033333
111PAK10.53421649
112TAF10.53347192
113PLK40.53247690
114PRKACA0.52488852
115WNK30.52402912
116BTK0.51908667
117CSNK2A20.51505980
118PRKCQ0.51082669
119DAPK20.51068497
120CSNK1D0.50654624
121CAMK2G0.50624578
122KDR0.50183393
123ERBB30.49560062
124NEK60.49301543
125IKBKB0.49216617
126WEE10.48196887
127ATR0.46410984
128STK110.46386649
129MAP2K20.45846618
130CAMKK20.45797340
131DYRK1B0.44936963
132PNCK0.44233041
133LCK0.43616206
134FGR0.41406063
135PRKG10.41135239
136PLK20.41023759
137NLK0.41011022
138PRKCD0.41004253
139CAMK10.40120140
140CLK10.39455692
141SGK4940.37199800
142SGK2230.37199800
143CSNK1E0.37158986
144NTRK30.33738841
145PRKCA0.31664407
146STK38L0.31347592
147CDK50.31274945
148NTRK20.31093829

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.91294998
2Ribosome_Homo sapiens_hsa030105.10554150
3Parkinsons disease_Homo sapiens_hsa050125.04808374
4Alzheimers disease_Homo sapiens_hsa050103.86786181
5Huntingtons disease_Homo sapiens_hsa050163.63134737
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.45606202
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.29386466
8Protein export_Homo sapiens_hsa030603.01966744
9Proteasome_Homo sapiens_hsa030502.97069548
10Cardiac muscle contraction_Homo sapiens_hsa042602.28111485
11RNA polymerase_Homo sapiens_hsa030202.26660674
12Fatty acid elongation_Homo sapiens_hsa000621.84454541
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74406947
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.64229171
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63653112
16Sulfur metabolism_Homo sapiens_hsa009201.45718354
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43908906
18Pyrimidine metabolism_Homo sapiens_hsa002401.40929472
19Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.28076418
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26690423
21Ether lipid metabolism_Homo sapiens_hsa005651.17937672
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17798164
23Arachidonic acid metabolism_Homo sapiens_hsa005901.16677159
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13259724
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12217581
26Hedgehog signaling pathway_Homo sapiens_hsa043401.09043278
27Circadian rhythm_Homo sapiens_hsa047101.07686604
28Collecting duct acid secretion_Homo sapiens_hsa049661.06292912
29Linoleic acid metabolism_Homo sapiens_hsa005911.05629687
30Homologous recombination_Homo sapiens_hsa034401.01482050
31Nitrogen metabolism_Homo sapiens_hsa009101.01470519
32Steroid biosynthesis_Homo sapiens_hsa001001.00181501
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95583434
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94804761
35Spliceosome_Homo sapiens_hsa030400.94268007
36SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92432730
37Propanoate metabolism_Homo sapiens_hsa006400.90373512
38Metabolic pathways_Homo sapiens_hsa011000.90353883
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89056841
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87958077
41Purine metabolism_Homo sapiens_hsa002300.87627981
42Non-homologous end-joining_Homo sapiens_hsa034500.87592499
43Peroxisome_Homo sapiens_hsa041460.86068808
44Chemical carcinogenesis_Homo sapiens_hsa052040.85167960
45Glutathione metabolism_Homo sapiens_hsa004800.84424554
46One carbon pool by folate_Homo sapiens_hsa006700.82041975
47Nucleotide excision repair_Homo sapiens_hsa034200.81931639
48Basal transcription factors_Homo sapiens_hsa030220.81675951
49Tyrosine metabolism_Homo sapiens_hsa003500.81527871
50Vitamin digestion and absorption_Homo sapiens_hsa049770.80620812
51Rheumatoid arthritis_Homo sapiens_hsa053230.80582818
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77827935
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77665344
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77499736
55Graft-versus-host disease_Homo sapiens_hsa053320.77147922
56Mismatch repair_Homo sapiens_hsa034300.76343221
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76102990
58Vibrio cholerae infection_Homo sapiens_hsa051100.75152812
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.74354667
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74179067
61RNA degradation_Homo sapiens_hsa030180.73783199
62Phototransduction_Homo sapiens_hsa047440.70699105
63Sulfur relay system_Homo sapiens_hsa041220.70283255
64Nicotine addiction_Homo sapiens_hsa050330.69089259
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69080767
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68070768
67Histidine metabolism_Homo sapiens_hsa003400.66413013
68Phenylalanine metabolism_Homo sapiens_hsa003600.65821181
69Retinol metabolism_Homo sapiens_hsa008300.64643764
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.64284509
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63170177
72Cocaine addiction_Homo sapiens_hsa050300.63072969
73DNA replication_Homo sapiens_hsa030300.62337458
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62231756
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61451538
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58705009
77Autoimmune thyroid disease_Homo sapiens_hsa053200.58409022
78RNA transport_Homo sapiens_hsa030130.58044655
79Fanconi anemia pathway_Homo sapiens_hsa034600.57178098
80Serotonergic synapse_Homo sapiens_hsa047260.57091727
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.56796897
82Folate biosynthesis_Homo sapiens_hsa007900.56309836
83Basal cell carcinoma_Homo sapiens_hsa052170.56009108
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55927834
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.55714797
86Olfactory transduction_Homo sapiens_hsa047400.54518132
87Allograft rejection_Homo sapiens_hsa053300.53499400
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52529996
89Asthma_Homo sapiens_hsa053100.52331092
90Sphingolipid metabolism_Homo sapiens_hsa006000.52170544
91Ovarian steroidogenesis_Homo sapiens_hsa049130.51350842
92Tryptophan metabolism_Homo sapiens_hsa003800.50380256
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.49739941
94Fructose and mannose metabolism_Homo sapiens_hsa000510.49247765
95Butanoate metabolism_Homo sapiens_hsa006500.49165917
96Glutamatergic synapse_Homo sapiens_hsa047240.48392875
97Primary immunodeficiency_Homo sapiens_hsa053400.48133844
98Calcium signaling pathway_Homo sapiens_hsa040200.47361581
99Pyruvate metabolism_Homo sapiens_hsa006200.46573006
100Mineral absorption_Homo sapiens_hsa049780.44206781
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43097808
102beta-Alanine metabolism_Homo sapiens_hsa004100.40381849
103Taste transduction_Homo sapiens_hsa047420.38092988
104Hematopoietic cell lineage_Homo sapiens_hsa046400.37829720
105Fat digestion and absorption_Homo sapiens_hsa049750.37137876
106Circadian entrainment_Homo sapiens_hsa047130.37106275
107Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36587479
108Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36225322
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.36224588
110Arginine and proline metabolism_Homo sapiens_hsa003300.35854046
111Selenocompound metabolism_Homo sapiens_hsa004500.34044119
112Regulation of autophagy_Homo sapiens_hsa041400.32481186
113Base excision repair_Homo sapiens_hsa034100.30905121
114Other glycan degradation_Homo sapiens_hsa005110.30576200
115Amphetamine addiction_Homo sapiens_hsa050310.30131833
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29480461
117Hippo signaling pathway_Homo sapiens_hsa043900.29410062
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.28209457
119Caffeine metabolism_Homo sapiens_hsa002320.28107168
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27230010
121Systemic lupus erythematosus_Homo sapiens_hsa053220.25654042
122Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.25212833
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24598445
124Phagosome_Homo sapiens_hsa041450.24243915
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24120372
126Pentose phosphate pathway_Homo sapiens_hsa000300.24116298
127Fatty acid degradation_Homo sapiens_hsa000710.21215162
128African trypanosomiasis_Homo sapiens_hsa051430.20264870
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.19669541
130Carbon metabolism_Homo sapiens_hsa012000.16077738
131GABAergic synapse_Homo sapiens_hsa047270.15753810
132Starch and sucrose metabolism_Homo sapiens_hsa005000.15192482
133Morphine addiction_Homo sapiens_hsa050320.13523482
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13050756
135Type I diabetes mellitus_Homo sapiens_hsa049400.12733958

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