COX20P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1outer ear morphogenesis (GO:0042473)8.44748037
2regulation of dopamine uptake involved in synaptic transmission (GO:0051584)8.07312204
3regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)8.07312204
4artery development (GO:0060840)7.67314184
5polyamine biosynthetic process (GO:0006596)7.32486248
6facial nerve structural organization (GO:0021612)7.06312483
7adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)6.86046086
8negative regulation of sodium ion transport (GO:0010766)6.17648220
9synaptic transmission, dopaminergic (GO:0001963)5.74410308
10prepulse inhibition (GO:0060134)5.73670645
11behavioral response to cocaine (GO:0048148)5.72606635
12regulation of neurotransmitter uptake (GO:0051580)5.59164443
13arachidonic acid secretion (GO:0050482)5.51528216
14icosanoid secretion (GO:0032309)5.51528216
15multicellular organismal movement (GO:0050879)5.49876252
16musculoskeletal movement (GO:0050881)5.49876252
17G-protein coupled receptor internalization (GO:0002031)5.46559660
18low-density lipoprotein particle clearance (GO:0034383)5.33442184
19amine catabolic process (GO:0009310)5.23127318
20cellular biogenic amine catabolic process (GO:0042402)5.23127318
21polyamine metabolic process (GO:0006595)5.17922329
22response to histamine (GO:0034776)5.09299745
23reflex (GO:0060004)5.08503227
24cranial nerve structural organization (GO:0021604)5.06164297
25negative regulation of oligodendrocyte differentiation (GO:0048715)5.00812389
26cellular biogenic amine biosynthetic process (GO:0042401)5.00457051
27ubiquinone biosynthetic process (GO:0006744)4.78994172
28heparan sulfate proteoglycan biosynthetic process (GO:0015012)4.74220842
29amine biosynthetic process (GO:0009309)4.72303233
30fatty acid derivative transport (GO:1901571)4.51322147
31icosanoid transport (GO:0071715)4.51322147
32regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.38377293
33mitochondrion morphogenesis (GO:0070584)4.33611912
34ubiquinone metabolic process (GO:0006743)4.31708193
35regulation of synaptic transmission, dopaminergic (GO:0032225)4.25658710
36fatty acid homeostasis (GO:0055089)4.21696758
37cochlea development (GO:0090102)4.01314004
38cardiovascular system development (GO:0072358)3.99115898
39RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.98252872
40tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.98252872
41glycerol metabolic process (GO:0006071)3.90224413
42quinone biosynthetic process (GO:1901663)3.87820422
43platelet dense granule organization (GO:0060155)3.85900323
44DNA deamination (GO:0045006)3.84914328
45negative regulation of glial cell differentiation (GO:0045686)3.76612540
46regulation of proton transport (GO:0010155)3.76231357
47substrate-independent telencephalic tangential migration (GO:0021826)3.75203010
48substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.75203010
49negative regulation of synaptic transmission, GABAergic (GO:0032229)3.72385820
50positive regulation of renal sodium excretion (GO:0035815)3.71398389
51positive regulation of cellular amine metabolic process (GO:0033240)3.70347965
52cell morphogenesis involved in neuron differentiation (GO:0048667)3.58763394
53negative regulation of mast cell activation (GO:0033004)3.58345172
54regulation of circadian sleep/wake cycle (GO:0042749)3.47014744
55regulation of circadian sleep/wake cycle, sleep (GO:0045187)3.47014744
56negative regulation of nitric-oxide synthase activity (GO:0051001)3.40049568
57cellular response to interferon-beta (GO:0035458)3.39935314
58cytidine deamination (GO:0009972)3.39823618
59cytidine metabolic process (GO:0046087)3.39823618
60cytidine catabolic process (GO:0006216)3.39823618
61alditol metabolic process (GO:0019400)3.39185145
62regulation of dopamine secretion (GO:0014059)3.36532459
63response to amphetamine (GO:0001975)3.33608943
64peristalsis (GO:0030432)3.32154421
65nephron tubule morphogenesis (GO:0072078)3.31468096
66nephron epithelium morphogenesis (GO:0072088)3.31468096
67regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.22864476
68circadian sleep/wake cycle process (GO:0022410)3.20785560
69regulation of mitochondrial fission (GO:0090140)3.18229153
70anatomical structure arrangement (GO:0048532)3.16033308
71mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.15784004
72mitochondrial respiratory chain complex I assembly (GO:0032981)3.15784004
73NADH dehydrogenase complex assembly (GO:0010257)3.15784004
74detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.15715552
75mitotic cell cycle arrest (GO:0071850)3.14722086
76L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.12723581
77negative regulation of telomere maintenance (GO:0032205)3.10002793
78regulation of cellular respiration (GO:0043457)3.08415036
79regulation of establishment of cell polarity (GO:2000114)3.01639049
80spliceosomal complex assembly (GO:0000245)2.99943419
81natural killer cell mediated immunity (GO:0002228)2.95985010
82natural killer cell mediated cytotoxicity (GO:0042267)2.95985010
83behavioral response to nicotine (GO:0035095)2.95722291
84respiratory chain complex IV assembly (GO:0008535)2.92795022
85plasma lipoprotein particle clearance (GO:0034381)2.89022773
86heparan sulfate proteoglycan metabolic process (GO:0030201)2.86665535
87L-methionine salvage (GO:0071267)2.86044310
88L-methionine biosynthetic process (GO:0071265)2.86044310
89amino acid salvage (GO:0043102)2.86044310
90diacylglycerol metabolic process (GO:0046339)2.84538687
91motor neuron axon guidance (GO:0008045)2.83287789
92pyrimidine ribonucleoside catabolic process (GO:0046133)2.76539706
93somite development (GO:0061053)2.74625390
94regulation of interleukin-8 secretion (GO:2000482)2.74102126
95proteoglycan biosynthetic process (GO:0030166)2.72227848
96positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.71906335
97protein complex biogenesis (GO:0070271)2.70466056
98mitochondrial RNA metabolic process (GO:0000959)2.68656297
99negative regulation of gliogenesis (GO:0014014)2.66813149
100potassium ion import (GO:0010107)2.66407477

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse9.39369884
2ZNF274_21170338_ChIP-Seq_K562_Hela4.59002288
3VDR_22108803_ChIP-Seq_LS180_Human4.36109036
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.23939425
5EZH2_22144423_ChIP-Seq_EOC_Human3.08088277
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.79330777
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.37822876
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.34936839
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.30888760
10IGF1R_20145208_ChIP-Seq_DFB_Human2.26061813
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.20977004
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.18530932
13MYC_18940864_ChIP-ChIP_HL60_Human1.96263842
14GATA3_21878914_ChIP-Seq_MCF-7_Human1.84530153
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.80956364
16ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79704626
17CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.65235545
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64573167
19BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60296263
20KAP1_22055183_ChIP-Seq_ESCs_Mouse1.56065410
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.54032879
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53074051
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.50741509
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49718489
25GBX2_23144817_ChIP-Seq_PC3_Human1.47766013
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.45182867
27FOXA1_27270436_Chip-Seq_PROSTATE_Human1.45086873
28FOXA1_25329375_ChIP-Seq_VCAP_Human1.45086873
29BCAT_22108803_ChIP-Seq_LS180_Human1.43235573
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.40986758
31FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.40431823
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37034189
33NANOG_19829295_ChIP-Seq_ESCs_Human1.36292565
34SOX2_19829295_ChIP-Seq_ESCs_Human1.36292565
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.35389058
36TP53_22573176_ChIP-Seq_HFKS_Human1.33863424
37P300_19829295_ChIP-Seq_ESCs_Human1.28247171
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25774939
39SMAD4_21741376_ChIP-Seq_EPCs_Human1.22628771
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22267885
41HOXB7_26014856_ChIP-Seq_BT474_Human1.21550990
42ELK1_19687146_ChIP-ChIP_HELA_Human1.20991489
43REST_21632747_ChIP-Seq_MESCs_Mouse1.20252084
44NCOR_22424771_ChIP-Seq_293T_Human1.20145554
45EWS_26573619_Chip-Seq_HEK293_Human1.19706455
46FLI1_21867929_ChIP-Seq_TH2_Mouse1.17945200
47GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.16930317
48EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15892840
49VDR_23849224_ChIP-Seq_CD4+_Human1.15841300
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.15767594
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14483108
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14280839
53EED_16625203_ChIP-ChIP_MESCs_Mouse1.13771708
54RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12736569
55RNF2_27304074_Chip-Seq_NSC_Mouse1.11733515
56KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10978701
57JUN_21703547_ChIP-Seq_K562_Human1.10612924
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09948313
59KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08212199
60KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08212199
61KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08212199
62ER_23166858_ChIP-Seq_MCF-7_Human1.07375170
63AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06926822
64NANOG_20526341_ChIP-Seq_ESCs_Human1.06754554
65TCF4_23295773_ChIP-Seq_U87_Human1.06400667
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.05499484
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04935567
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03746367
69EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02980171
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00846179
71FOXH1_21741376_ChIP-Seq_EPCs_Human0.99669233
72PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97472577
73ERA_21632823_ChIP-Seq_H3396_Human0.97124452
74FOXH1_21741376_ChIP-Seq_ESCs_Human0.96756250
75AR_21572438_ChIP-Seq_LNCaP_Human0.96617644
76TAF2_19829295_ChIP-Seq_ESCs_Human0.95377833
77PRDM14_20953172_ChIP-Seq_ESCs_Human0.94908702
78FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94430273
79AR_25329375_ChIP-Seq_VCAP_Human0.93173672
80RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92921141
81TCF4_22108803_ChIP-Seq_LS180_Human0.91189524
82SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90654651
83GATA1_26923725_Chip-Seq_HPCs_Mouse0.90545447
84SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.90358825
85ELK4_26923725_Chip-Seq_MESODERM_Mouse0.89875180
86HTT_18923047_ChIP-ChIP_STHdh_Human0.89441799
87TDRD3_21172665_ChIP-Seq_MCF-7_Human0.88764691
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88268021
89FOXP3_21729870_ChIP-Seq_TREG_Human0.87926690
90GABP_19822575_ChIP-Seq_HepG2_Human0.87601168
91PCGF2_27294783_Chip-Seq_NPCs_Mouse0.86758273
92CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86649279
93STAT3_23295773_ChIP-Seq_U87_Human0.84764222
94EZH2_27294783_Chip-Seq_NPCs_Mouse0.84581416
95TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.83860634
96PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.83666415
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83448221
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83448221
99MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.82019757
100AR_20517297_ChIP-Seq_VCAP_Human0.81773350

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000678_abnormal_parathyroid_gland4.19727324
2MP0009046_muscle_twitch3.78224434
3MP0008877_abnormal_DNA_methylation3.19299022
4MP0008872_abnormal_physiological_respon3.06678138
5MP0002735_abnormal_chemical_nociception2.38034406
6MP0004147_increased_porphyrin_level2.20685303
7MP0003646_muscle_fatigue2.19830993
8MP0001440_abnormal_grooming_behavior2.18236329
9MP0008875_abnormal_xenobiotic_pharmacok2.06397191
10MP0000049_abnormal_middle_ear2.01480628
11MP0005451_abnormal_body_composition10.4134973
12MP0003938_abnormal_ear_development1.96684667
13MP0001905_abnormal_dopamine_level1.96619358
14MP0000569_abnormal_digit_pigmentation1.93779454
15MP0001486_abnormal_startle_reflex1.91890582
16MP0002102_abnormal_ear_morphology1.84277062
17MP0008007_abnormal_cellular_replicative1.82003078
18MP0006072_abnormal_retinal_apoptosis1.75368882
19MP0003195_calcinosis1.74942514
20MP0004142_abnormal_muscle_tone1.63977443
21MP0004145_abnormal_muscle_electrophysio1.61765881
22MP0002837_dystrophic_cardiac_calcinosis1.54413211
23MP0003119_abnormal_digestive_system1.50109599
24MP0002638_abnormal_pupillary_reflex1.44212402
25MP0002067_abnormal_sensory_capabilities1.41393064
26MP0004885_abnormal_endolymph1.41201298
27MP0006292_abnormal_olfactory_placode1.36116889
28MP0002876_abnormal_thyroid_physiology1.34695497
29MP0003806_abnormal_nucleotide_metabolis1.30089359
30MP0009745_abnormal_behavioral_response1.28079899
31MP0003718_maternal_effect1.26997596
32MP0008058_abnormal_DNA_repair1.26987694
33MP0002733_abnormal_thermal_nociception1.26344361
34MP0004130_abnormal_muscle_cell1.26075638
35MP0003787_abnormal_imprinting1.25949457
36MP0005551_abnormal_eye_electrophysiolog1.20245801
37MP0000230_abnormal_systemic_arterial1.18136079
38MP0003315_abnormal_perineum_morphology1.17948639
39MP0001986_abnormal_taste_sensitivity1.14319427
40MP0003890_abnormal_embryonic-extraembry1.13118639
41MP0002177_abnormal_outer_ear1.11892884
42MP0004742_abnormal_vestibular_system1.06355587
43MP0001970_abnormal_pain_threshold1.06276915
44MP0001968_abnormal_touch/_nociception1.01737567
45MP0002111_abnormal_tail_morphology1.01689359
46MP0002572_abnormal_emotion/affect_behav0.97785358
47MP0005671_abnormal_response_to0.95470073
48MP0002063_abnormal_learning/memory/cond0.94239098
49MP0003283_abnormal_digestive_organ0.93331341
50MP0002736_abnormal_nociception_after0.92969776
51MP0003011_delayed_dark_adaptation0.91734194
52MP0001485_abnormal_pinna_reflex0.86687201
53MP0000026_abnormal_inner_ear0.86349237
54MP0001502_abnormal_circadian_rhythm0.85889048
55MP0006276_abnormal_autonomic_nervous0.85679037
56MP0008932_abnormal_embryonic_tissue0.84896596
57MP0005253_abnormal_eye_physiology0.84889442
58MP0002938_white_spotting0.84536066
59MP0002069_abnormal_eating/drinking_beha0.84458811
60MP0003136_yellow_coat_color0.83462638
61MP0004133_heterotaxia0.81646115
62MP0002108_abnormal_muscle_morphology0.81227715
63MP0002095_abnormal_skin_pigmentation0.81152601
64MP0002272_abnormal_nervous_system0.80210240
65MP0008995_early_reproductive_senescence0.79343477
66MP0005174_abnormal_tail_pigmentation0.78745585
67MP0002928_abnormal_bile_duct0.75208573
68MP0008789_abnormal_olfactory_epithelium0.72371546
69MP0002132_abnormal_respiratory_system0.71898872
70MP0000427_abnormal_hair_cycle0.71871631
71MP0003941_abnormal_skin_development0.71694402
72MP0002653_abnormal_ependyma_morphology0.71589400
73MP0005410_abnormal_fertilization0.69674772
74MP0002693_abnormal_pancreas_physiology0.68455688
75MP0002160_abnormal_reproductive_system0.68308844
76MP0002064_seizures0.68131089
77MP0005195_abnormal_posterior_eye0.67912998
78MP0003880_abnormal_central_pattern0.66996636
79MP0009053_abnormal_anal_canal0.66836671
80MP0005452_abnormal_adipose_tissue0.66447761
81MP0001756_abnormal_urination0.66420665
82MP0001873_stomach_inflammation0.66222721
83MP0010094_abnormal_chromosome_stability0.64926717
84MP0005084_abnormal_gallbladder_morpholo0.64629342
85MP0003638_abnormal_response/metabolism_0.64106187
86MP0001529_abnormal_vocalization0.64077329
87MP0005408_hypopigmentation0.63362689
88MP0000778_abnormal_nervous_system0.62398903
89MP0005220_abnormal_exocrine_pancreas0.62214492
90MP0001324_abnormal_eye_pigmentation0.60069727
91MP0000372_irregular_coat_pigmentation0.58603806
92MP0002752_abnormal_somatic_nervous0.58519775
93MP0002734_abnormal_mechanical_nocicepti0.57160671
94MP0010307_abnormal_tumor_latency0.54313498
95MP0003755_abnormal_palate_morphology0.53229604
96MP0003693_abnormal_embryo_hatching0.51998435
97MP0002066_abnormal_motor_capabilities/c0.51902989
98MP0002557_abnormal_social/conspecific_i0.51489065
99MP0003122_maternal_imprinting0.51224766
100MP0005389_reproductive_system_phenotype0.50188238

Predicted human phenotypes

RankGene SetZ-score
111 pairs of ribs (HP:0000878)8.25414216
2Broad distal phalanx of finger (HP:0009836)7.20542899
3Short nail (HP:0001799)6.40602421
4Radial bowing (HP:0002986)5.28587205
5Spinal cord compression (HP:0002176)5.20701590
6Cupped ribs (HP:0000887)4.47128647
7Irregular vertebral endplates (HP:0003301)4.41681402
8Flared iliac wings (HP:0002869)4.39837393
9Missing ribs (HP:0000921)4.28408566
10Pancreatic fibrosis (HP:0100732)3.99996728
11True hermaphroditism (HP:0010459)3.94956482
12Pancreatic cysts (HP:0001737)3.76090109
13Large for gestational age (HP:0001520)3.70569770
14Short femoral neck (HP:0100864)3.65772092
15Molar tooth sign on MRI (HP:0002419)3.62263214
16Abnormality of midbrain morphology (HP:0002418)3.62263214
17Ovoid vertebral bodies (HP:0003300)3.60139296
18Bicuspid aortic valve (HP:0001647)3.54579308
19Abnormality of the vertebral endplates (HP:0005106)3.39971921
20Congenital, generalized hypertrichosis (HP:0004540)3.38969565
21Mesangial abnormality (HP:0001966)3.17765597
22Slender long bone (HP:0003100)3.15741812
23Furrowed tongue (HP:0000221)3.15324793
24Abnormal vertebral ossification (HP:0100569)3.13893784
25Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.13389957
26Bowing of the arm (HP:0006488)3.09417309
27Bowed forearm bones (HP:0003956)3.09417309
28Fragile skin (HP:0001030)3.08041304
29Genetic anticipation (HP:0003743)2.95455275
30Hypoplastic ischia (HP:0003175)2.88377770
31Coxa valga (HP:0002673)2.87289311
32Abnormality of carpal bone ossification (HP:0006257)2.86774722
33Exostoses (HP:0100777)2.86168955
34Delayed gross motor development (HP:0002194)2.82395417
35Gait imbalance (HP:0002141)2.79592278
36Birth length less than 3rd percentile (HP:0003561)2.76824549
37Sparse scalp hair (HP:0002209)2.75037878
38Congenital stationary night blindness (HP:0007642)2.71367467
39Aplasia/hypoplasia of the femur (HP:0005613)2.66616387
40Congenital primary aphakia (HP:0007707)2.66519442
41Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.65705295
42Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.61444366
43Cystic liver disease (HP:0006706)2.59072235
44Pendular nystagmus (HP:0012043)2.58475861
45Medial flaring of the eyebrow (HP:0010747)2.49982456
46Hyperventilation (HP:0002883)2.49516149
47Nephrogenic diabetes insipidus (HP:0009806)2.48315613
48Nephronophthisis (HP:0000090)2.40728506
49Soft skin (HP:0000977)2.39397109
50Hyperalaninemia (HP:0003348)2.38680069
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.38680069
52Abnormality of alanine metabolism (HP:0010916)2.38680069
53Progressive cerebellar ataxia (HP:0002073)2.37437721
54Sclerocornea (HP:0000647)2.33980455
55Metatarsus adductus (HP:0001840)2.33088685
56Male pseudohermaphroditism (HP:0000037)2.31894548
57Abnormality of the ischium (HP:0003174)2.30760709
58Abnormality of the radial head (HP:0003995)2.29927017
59Dislocated radial head (HP:0003083)2.29029516
60Short hallux (HP:0010109)2.23297812
61Carpal synostosis (HP:0009702)2.23285966
62Inability to walk (HP:0002540)2.21476065
63Dyskinesia (HP:0100660)2.20531830
64Broad metatarsal (HP:0001783)2.16395630
65Severe muscular hypotonia (HP:0006829)2.12643034
66Fair hair (HP:0002286)2.12623707
67Aplasia/Hypoplasia of the hallux (HP:0008362)2.08492121
68Methylmalonic acidemia (HP:0002912)2.05783629
69Conical tooth (HP:0000698)2.04448996
70Abnormal hand bone ossification (HP:0010660)2.04158071
71Type II lissencephaly (HP:0007260)2.00049456
72Synostosis involving bones of the hand (HP:0004278)1.95705396
73Anencephaly (HP:0002323)1.94699986
74Patellar aplasia (HP:0006443)1.93866935
75Microretrognathia (HP:0000308)1.93693760
76Aplasia/Hypoplasia of the tongue (HP:0010295)1.92025557
77Aplastic anemia (HP:0001915)1.91149977
78Aplasia/Hypoplasia of the patella (HP:0006498)1.86654607
79Abolished electroretinogram (ERG) (HP:0000550)1.86402180
80Abnormal ossification of hand bones (HP:0005921)1.86332052
81Left ventricular hypertrophy (HP:0001712)1.83928225
82Vaginal atresia (HP:0000148)1.83706593
83Broad-based gait (HP:0002136)1.83681482
84Hyperglycinuria (HP:0003108)1.82390497
85Hyperglycinemia (HP:0002154)1.82269125
86Diplopia (HP:0000651)1.79369846
87Abnormality of binocular vision (HP:0011514)1.79369846
88Global brain atrophy (HP:0002283)1.78159839
89Genital tract atresia (HP:0001827)1.75283206
90Aganglionic megacolon (HP:0002251)1.75045105
91Cleft eyelid (HP:0000625)1.72427922
92Abnormality of the renal medulla (HP:0100957)1.72018829
93Flat face (HP:0012368)1.71574250
94Keratoconus (HP:0000563)1.68047524
95Increased corneal curvature (HP:0100692)1.68047524
96Albinism (HP:0001022)1.67452929
97Hypoplasia of the ulna (HP:0003022)1.67345073
98Acute encephalopathy (HP:0006846)1.67267266
99Poor coordination (HP:0002370)1.65461444
100Pathologic fracture (HP:0002756)1.64852777

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK24.73989962
2NTRK34.32423295
3ACVR1B4.09950970
4GRK13.72738626
5TLK13.56961320
6BMPR1B3.48980372
7NEK13.00007344
8MAP3K22.78960649
9ZAK2.77882733
10KSR22.76244564
11WNK12.26317160
12KSR12.16327232
13TGFBR12.10456721
14TIE11.97997399
15RAF11.97787769
16FRK1.91988123
17NUAK11.78567943
18NEK21.68360427
19MKNK21.47251900
20PAK61.46584449
21MAP4K21.43568798
22WNK41.36142997
23LIMK11.27588070
24PIK3CA1.25261387
25TXK1.22718211
26BCKDK1.22189378
27WNK31.14577337
28CDC71.12820532
29EPHB21.10943257
30VRK11.10286991
31CSNK1G31.09748800
32MAPK151.06255165
33CSNK1G20.96149195
34MARK10.93351465
35AURKA0.91799805
36CSNK1G10.90931900
37MAP2K10.90556041
38PRKCH0.87585768
39CSNK1A1L0.85351749
40MAP2K70.81470361
41CLK10.79823479
42MAP3K90.78045738
43PAK30.76192793
44MKNK10.75110069
45OXSR10.74862150
46BUB10.74672367
47CDK40.74566960
48PRKCG0.74491900
49KDR0.73979576
50DYRK20.72744609
51ADRBK10.72598376
52VRK20.69640331
53MAPK130.69201392
54RET0.66760229
55KIT0.66396429
56PLK30.62204919
57PRKCQ0.60384885
58MAP3K110.57814874
59PDK20.57745598
60TNIK0.56913667
61PLK10.56587861
62MUSK0.54022608
63ALK0.53849467
64CHEK20.53449103
65MET0.51627148
66CSNK1D0.50110673
67FLT30.47787665
68DAPK20.47374558
69RPS6KA50.46070344
70NEK90.45307058
71INSRR0.43579409
72MARK20.41980570
73MAP3K10.41947577
74MST40.40393956
75PLK40.38845771
76ATR0.35577559
77CAMK2D0.35186235
78PRKCE0.34769493
79PTK2B0.34251817
80MAP3K120.34105637
81STK38L0.33616540
82CAMK2A0.32602752
83SIK20.32096382
84MINK10.29814890
85PINK10.28753490
86LCK0.28657953
87CDK50.28228173
88STK390.27637451
89PBK0.26782894
90MAP3K40.26617554
91CSNK1E0.26562411
92CSNK2A10.25764385
93PRKCI0.25243754
94SYK0.25082925
95PRKACA0.24451937
96BRSK20.23689420
97SGK10.23565005
98TESK20.22832480
99STK160.22318539
100CSNK1A10.22050595

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004506.19807415
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.34106698
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.42971929
4Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005343.20900625
5Phototransduction_Homo sapiens_hsa047442.74011786
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.69951592
7Oxidative phosphorylation_Homo sapiens_hsa001902.38917713
8Regulation of autophagy_Homo sapiens_hsa041402.29620559
9Parkinsons disease_Homo sapiens_hsa050121.97533929
10Sulfur metabolism_Homo sapiens_hsa009201.90772673
11Fat digestion and absorption_Homo sapiens_hsa049751.85915499
12Ether lipid metabolism_Homo sapiens_hsa005651.69917201
13Nitrogen metabolism_Homo sapiens_hsa009101.66496907
14Peroxisome_Homo sapiens_hsa041461.62927278
15Proteasome_Homo sapiens_hsa030501.57247703
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55646189
17Ribosome_Homo sapiens_hsa030101.52827854
18Protein export_Homo sapiens_hsa030601.50956452
19RNA degradation_Homo sapiens_hsa030181.50472675
20Linoleic acid metabolism_Homo sapiens_hsa005911.48755689
21Cardiac muscle contraction_Homo sapiens_hsa042601.48328856
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.46047273
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45338048
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40123836
25Butanoate metabolism_Homo sapiens_hsa006501.35919540
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31623477
27Nicotine addiction_Homo sapiens_hsa050331.31076803
28Alzheimers disease_Homo sapiens_hsa050101.30873269
29Fanconi anemia pathway_Homo sapiens_hsa034601.28860462
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.27276142
31Homologous recombination_Homo sapiens_hsa034401.23202585
32RNA polymerase_Homo sapiens_hsa030201.22525645
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.20019405
34Glycerolipid metabolism_Homo sapiens_hsa005611.17938999
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16875131
36Huntingtons disease_Homo sapiens_hsa050161.14664486
37Morphine addiction_Homo sapiens_hsa050321.13014973
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01304168
39Pyrimidine metabolism_Homo sapiens_hsa002400.99142742
40Mineral absorption_Homo sapiens_hsa049780.98293914
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97946748
42One carbon pool by folate_Homo sapiens_hsa006700.96736594
43Basal transcription factors_Homo sapiens_hsa030220.95199358
44Mismatch repair_Homo sapiens_hsa034300.90089469
45Caffeine metabolism_Homo sapiens_hsa002320.89799134
46Insulin secretion_Homo sapiens_hsa049110.89615339
47GABAergic synapse_Homo sapiens_hsa047270.87966757
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86300122
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.83227056
50ABC transporters_Homo sapiens_hsa020100.81769714
51Dopaminergic synapse_Homo sapiens_hsa047280.81066219
52Propanoate metabolism_Homo sapiens_hsa006400.79346932
53Taste transduction_Homo sapiens_hsa047420.77421605
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75372510
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73512979
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73253945
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72217427
58Chemical carcinogenesis_Homo sapiens_hsa052040.71980310
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71751397
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68699409
61DNA replication_Homo sapiens_hsa030300.68225397
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67191025
63Olfactory transduction_Homo sapiens_hsa047400.64620189
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62190884
65Sulfur relay system_Homo sapiens_hsa041220.59888302
66Nucleotide excision repair_Homo sapiens_hsa034200.59710760
67Serotonergic synapse_Homo sapiens_hsa047260.56077899
68Circadian rhythm_Homo sapiens_hsa047100.55576496
69Glutamatergic synapse_Homo sapiens_hsa047240.55509289
70Purine metabolism_Homo sapiens_hsa002300.54526321
71Metabolic pathways_Homo sapiens_hsa011000.52146154
72Histidine metabolism_Homo sapiens_hsa003400.52136253
73Primary immunodeficiency_Homo sapiens_hsa053400.51621003
74Circadian entrainment_Homo sapiens_hsa047130.51310923
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.51120481
76Retinol metabolism_Homo sapiens_hsa008300.50252587
77Tryptophan metabolism_Homo sapiens_hsa003800.48139017
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48038857
79beta-Alanine metabolism_Homo sapiens_hsa004100.46964316
80Spliceosome_Homo sapiens_hsa030400.46864577
81Cholinergic synapse_Homo sapiens_hsa047250.46814514
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44921396
83Ovarian steroidogenesis_Homo sapiens_hsa049130.43608857
84Cocaine addiction_Homo sapiens_hsa050300.43020022
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41857883
86Arachidonic acid metabolism_Homo sapiens_hsa005900.40535095
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.40141644
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39065834
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.36710198
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36593098
91Arginine and proline metabolism_Homo sapiens_hsa003300.36582954
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35607084
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35146218
94RNA transport_Homo sapiens_hsa030130.34786151
95Gastric acid secretion_Homo sapiens_hsa049710.33220016
96Thyroid hormone synthesis_Homo sapiens_hsa049180.32667627
97Hippo signaling pathway_Homo sapiens_hsa043900.31336668
98Salivary secretion_Homo sapiens_hsa049700.29021739
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.27438314
100Bile secretion_Homo sapiens_hsa049760.22898541

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