ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.23264482
2	cytidine metabolic process (GO:0046087)	5.41309287
3	cytidine catabolic process (GO:0006216)	5.41309287
4	cytidine deamination (GO:0009972)	5.41309287
5	viral transcription (GO:0019083)	5.25454709
6	spliceosomal complex assembly (GO:0000245)	5.08758250
7	pyrimidine ribonucleoside catabolic process (GO:0046133)	5.04005255
8	translational termination (GO:0006415)	4.99525250
9	mature B cell differentiation involved in immune response (GO:0002313)	4.61174143
10	DNA deamination (GO:0045006)	4.56138092
11	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.55713084
12	sequestering of actin monomers (GO:0042989)	4.54753600
13	nonmotile primary cilium assembly (GO:0035058)	4.24566050
14	translational elongation (GO:0006414)	4.22294615
15	meiotic chromosome segregation (GO:0045132)	4.21849925
16	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.13614946
17	ribosomal small subunit biogenesis (GO:0042274)	4.11868319
18	protein targeting to ER (GO:0045047)	4.04844341
19	cotranslational protein targeting to membrane (GO:0006613)	4.04371695
20	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.99021748
21	viral life cycle (GO:0019058)	3.92472171
22	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.91532737
23	resolution of meiotic recombination intermediates (GO:0000712)	3.86169783
24	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.86133412
25	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.85890547
26	cellular protein complex disassembly (GO:0043624)	3.79912201
27	mature B cell differentiation (GO:0002335)	3.76484778
28	negative regulation of heart rate (GO:0010459)	3.74873225
29	protein localization to endoplasmic reticulum (GO:0070972)	3.70012404
30	cellular response to interleukin-15 (GO:0071350)	3.62300519
31	translational initiation (GO:0006413)	3.53812838
32	ubiquinone biosynthetic process (GO:0006744)	3.51692539
33	behavioral response to nicotine (GO:0035095)	3.51285580
34	oocyte development (GO:0048599)	3.50680263
35	negative T cell selection (GO:0043383)	3.49076065
36	protein neddylation (GO:0045116)	3.47490698
37	neural tube formation (GO:0001841)	3.45471252
38	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	3.43994750
39	regulation of B cell receptor signaling pathway (GO:0050855)	3.43927425
40	immunoglobulin mediated immune response (GO:0016064)	3.35513561
41	ubiquinone metabolic process (GO:0006743)	3.34494433
42	ribonucleoprotein complex disassembly (GO:0032988)	3.33529123
43	regulation of interleukin-2 biosynthetic process (GO:0045076)	3.31780079
44	substrate-independent telencephalic tangential migration (GO:0021826)	3.24618427
45	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.24618427
46	response to interleukin-15 (GO:0070672)	3.23480243
47	protein localization to cilium (GO:0061512)	3.20778850
48	macromolecular complex disassembly (GO:0032984)	3.19293426
49	protein complex disassembly (GO:0043241)	3.18206732
50	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.16872322
51	negative thymic T cell selection (GO:0045060)	3.08561812
52	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	3.03180352
53	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.01937102
54	mRNA catabolic process (GO:0006402)	3.01809708
55	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.99332557
56	tongue development (GO:0043586)	2.98148287
57	regulation of T-helper 1 cell differentiation (GO:0045625)	2.96985313
58	B cell activation involved in immune response (GO:0002312)	2.96464292
59	positive regulation of histone H3-K4 methylation (GO:0051571)	2.95059824
60	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.94511808
61	polyamine biosynthetic process (GO:0006596)	2.94384114
62	quinone biosynthetic process (GO:1901663)	2.93129193
63	organelle disassembly (GO:1903008)	2.92021685
64	negative regulation of alpha-beta T cell activation (GO:0046636)	2.91376009
65	iron-sulfur cluster assembly (GO:0016226)	2.90888181
66	metallo-sulfur cluster assembly (GO:0031163)	2.90888181
67	T cell costimulation (GO:0031295)	2.88735254
68	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.88401178
69	neuron fate determination (GO:0048664)	2.87650801
70	translation (GO:0006412)	2.86727085
71	B cell mediated immunity (GO:0019724)	2.86045643
72	lymphocyte costimulation (GO:0031294)	2.85269143
73	positive regulation of interleukin-8 secretion (GO:2000484)	2.83469938
74	interferon-gamma-mediated signaling pathway (GO:0060333)	2.82734276
75	telomere maintenance via telomerase (GO:0007004)	2.82616281
76	synapsis (GO:0007129)	2.80532395
77	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.79540886
78	isotype switching (GO:0045190)	2.79540886
79	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.79540886
80	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.77242603
81	RNA catabolic process (GO:0006401)	2.76855421
82	pyrimidine nucleoside catabolic process (GO:0046135)	2.72714582
83	T cell apoptotic process (GO:0070231)	2.72603816
84	T cell migration (GO:0072678)	2.72324519
85	tachykinin receptor signaling pathway (GO:0007217)	2.69477966
86	B cell receptor signaling pathway (GO:0050853)	2.67765119
87	protein targeting to membrane (GO:0006612)	2.66917276
88	DNA demethylation (GO:0080111)	2.66346082
89	response to interferon-beta (GO:0035456)	2.66328058
90	positive regulation of protein homodimerization activity (GO:0090073)	2.64039336
91	positive regulation of gamma-delta T cell activation (GO:0046645)	2.61518890
92	left/right axis specification (GO:0070986)	2.61069492
93	regulation of chromatin binding (GO:0035561)	2.60498157
94	maturation of SSU-rRNA (GO:0030490)	2.59918979
95	regulation of alpha-beta T cell proliferation (GO:0046640)	2.56365974
96	positive regulation of Notch signaling pathway (GO:0045747)	2.56103421
97	negative regulation of membrane potential (GO:0045837)	2.54954607
98	negative regulation of viral genome replication (GO:0045071)	2.53653604
99	protein-cofactor linkage (GO:0018065)	2.51447934
100	positive regulation of vascular permeability (GO:0043117)	2.51335755

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	8.24189500
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	7.94412222
3	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.80418086
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.00724756
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.96361000
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.87799363
7	VDR_23849224_ChIP-Seq_CD4+_Human	2.69412381
8	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.57116451
9	VDR_22108803_ChIP-Seq_LS180_Human	2.54483954
10	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.52534703
11	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.45390923
12	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.38484527
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.34407105
14	IRF1_19129219_ChIP-ChIP_H3396_Human	2.20432340
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.19452573
16	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.13084556
17	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.06786827
18	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.05225260
19	ZNF274_21170338_ChIP-Seq_K562_Hela	2.01811205
20	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.01528800
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.95584432
22	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.89578166
23	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.85256287
24	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.81159377
25	ELK1_19687146_ChIP-ChIP_HELA_Human	1.78655921
26	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.64216040
27	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.62732157
28	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.59500841
29	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.56807676
30	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.56498812
31	MYB_26560356_Chip-Seq_TH2_Human	1.56485778
32	FOXP3_21729870_ChIP-Seq_TREG_Human	1.54839124
33	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.50550653
34	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.45638430
35	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.41584565
36	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.41208486
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.41103625
38	GATA3_26560356_Chip-Seq_TH2_Human	1.37052362
39	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.36325891
40	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.31000228
41	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.27634262
42	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.27495603
43	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.25439362
44	CIITA_25753668_ChIP-Seq_RAJI_Human	1.23567918
45	TAF15_26573619_Chip-Seq_HEK293_Human	1.23411750
46	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.19769700
47	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.16075969
48	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.15776215
49	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.14816658
50	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.13485614
51	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.13258170
52	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.11057049
53	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.10750557
54	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.07694153
55	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06949087
56	GABP_19822575_ChIP-Seq_HepG2_Human	1.06456505
57	TTF2_22483619_ChIP-Seq_HELA_Human	1.05953138
58	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04267359
59	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04267359
60	MYB_26560356_Chip-Seq_TH1_Human	1.03266792
61	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.03044058
62	EWS_26573619_Chip-Seq_HEK293_Human	1.02536511
63	GATA3_27048872_Chip-Seq_THYMUS_Human	1.02190400
64	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.00718577
65	SPI1_23547873_ChIP-Seq_NB4_Human	1.00380968
66	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.00000447
67	TP53_22573176_ChIP-Seq_HFKS_Human	0.99983234
68	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.99766731
69	IGF1R_20145208_ChIP-Seq_DFB_Human	0.99375105
70	CTCF_18555785_Chip-Seq_ESCs_Mouse	0.98929542
71	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.98381162
72	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.98308044
73	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98037065
74	MYC_19829295_ChIP-Seq_ESCs_Human	0.95324031
75	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.93992536
76	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.93044280
77	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.92490233
78	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.92401400
79	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.91851704
80	MYC_22102868_ChIP-Seq_BL_Human	0.91143340
81	NCOR_22424771_ChIP-Seq_293T_Human	0.90793822
82	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.89634937
83	ER_23166858_ChIP-Seq_MCF-7_Human	0.88673417
84	IRF8_27001747_Chip-Seq_BMDM_Mouse	0.88359886
85	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.87972248
86	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.86540776
87	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.84933854
88	RUNX1_27457419_Chip-Seq_LIVER_Mouse	0.84481220
89	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.83572346
90	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.82408078
91	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.80622073
92	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.80486568
93	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.79623287
94	P300_19829295_ChIP-Seq_ESCs_Human	0.79374027
95	SOX3_22085726_ChIP-Seq_MUSCLE_Mouse	0.79221830
96	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.78803631
97	P300_18555785_Chip-Seq_ESCs_Mouse	0.78528844
98	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.78369781
99	AR_20517297_ChIP-Seq_VCAP_Human	0.78244877
100	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.76961025

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003183_abnormal_peptide_metabolism	4.57982291
2	MP0001835_abnormal_antigen_presentation	3.74968420
3	MP0005671_abnormal_response_to	3.61675900
4	MP0000685_abnormal_immune_system	3.56733469
5	MP0006072_abnormal_retinal_apoptosis	3.56423456
6	MP0000372_irregular_coat_pigmentation	3.37396937
7	MP0002163_abnormal_gland_morphology	3.10659388
8	MP0001790_abnormal_immune_system	3.06903134
9	MP0005387_immune_system_phenotype	3.06903134
10	MP0001800_abnormal_humoral_immune	2.94441258
11	MP0008789_abnormal_olfactory_epithelium	2.61709698
12	MP0005645_abnormal_hypothalamus_physiol	2.57780292
13	MP0008057_abnormal_DNA_replication	2.52890723
14	MP0005499_abnormal_olfactory_system	2.25622592
15	MP0005394_taste/olfaction_phenotype	2.25622592
16	MP0000566_synostosis	2.08005084
17	MP0005379_endocrine/exocrine_gland_phen	2.06055719
18	MP0002928_abnormal_bile_duct	2.05288272
19	MP0005000_abnormal_immune_tolerance	2.04079501
20	MP0002452_abnormal_antigen_presenting	1.98847934
21	MP0002723_abnormal_immune_serum	1.98676975
22	MP0006292_abnormal_olfactory_placode	1.90854293
23	MP0009785_altered_susceptibility_to	1.77758128
24	MP0009379_abnormal_foot_pigmentation	1.74445109
25	MP0002420_abnormal_adaptive_immunity	1.72081023
26	MP0002938_white_spotting	1.68124894
27	MP0001819_abnormal_immune_cell	1.67910049
28	MP0003252_abnormal_bile_duct	1.67003916
29	MP0004142_abnormal_muscle_tone	1.66733495
30	MP0005084_abnormal_gallbladder_morpholo	1.64572095
31	MP0001346_abnormal_lacrimal_gland	1.63081675
32	MP0002095_abnormal_skin_pigmentation	1.58571424
33	MP0001529_abnormal_vocalization	1.58318870
34	MP0002148_abnormal_hypersensitivity_rea	1.58019616
35	MP0005075_abnormal_melanosome_morpholog	1.52686367
36	MP0005253_abnormal_eye_physiology	1.50739031
37	MP0001873_stomach_inflammation	1.49126756
38	MP0005025_abnormal_response_to	1.39156006
39	MP0002234_abnormal_pharynx_morphology	1.37747864
40	MP0004145_abnormal_muscle_electrophysio	1.35211545
41	MP0002138_abnormal_hepatobiliary_system	1.33439429
42	MP0010155_abnormal_intestine_physiology	1.33380345
43	MP0005310_abnormal_salivary_gland	1.30652581
44	MP0003763_abnormal_thymus_physiology	1.28630316
45	MP0003880_abnormal_central_pattern	1.28360554
46	MP0002398_abnormal_bone_marrow	1.27186553
47	MP0006035_abnormal_mitochondrial_morpho	1.27026757
48	MP0000716_abnormal_immune_system	1.26456528
49	MP0008872_abnormal_physiological_respon	1.25943532
50	MP0005647_abnormal_sex_gland	1.20745310
51	MP0002653_abnormal_ependyma_morphology	1.17793885
52	MP0004147_increased_porphyrin_level	1.12172909
53	MP0003646_muscle_fatigue	1.11018892
54	MP0009333_abnormal_splenocyte_physiolog	1.09523285
55	MP0002272_abnormal_nervous_system	1.04113970
56	MP0001119_abnormal_female_reproductive	1.03940407
57	MP0000569_abnormal_digit_pigmentation	1.03448600
58	MP0005174_abnormal_tail_pigmentation	1.03015745
59	MP0005083_abnormal_biliary_tract	1.02770970
60	MP0005408_hypopigmentation	1.02747019
61	MP0010094_abnormal_chromosome_stability	1.00824941
62	MP0002429_abnormal_blood_cell	0.99903749
63	MP0002210_abnormal_sex_determination	0.98762924
64	MP0000689_abnormal_spleen_morphology	0.98461665
65	MP0002722_abnormal_immune_system	0.96841042
66	MP0004381_abnormal_hair_follicle	0.94991818
67	MP0003011_delayed_dark_adaptation	0.93151042
68	MP0004742_abnormal_vestibular_system	0.92623308
69	MP0001845_abnormal_inflammatory_respons	0.92289193
70	MP0002166_altered_tumor_susceptibility	0.89677637
71	MP0003866_abnormal_defecation	0.84985775
72	MP0002419_abnormal_innate_immunity	0.83665605
73	MP0001984_abnormal_olfaction	0.82651871
74	MP0005551_abnormal_eye_electrophysiolog	0.82568502
75	MP0008961_abnormal_basal_metabolism	0.79630472
76	MP0001986_abnormal_taste_sensitivity	0.77657476
77	MP0000631_abnormal_neuroendocrine_gland	0.73715259
78	MP0009764_decreased_sensitivity_to	0.71295865
79	MP0000639_abnormal_adrenal_gland	0.68823718
80	MP0000653_abnormal_sex_gland	0.68469806
81	MP0000858_altered_metastatic_potential	0.68464898
82	MP0008058_abnormal_DNA_repair	0.68062248
83	MP0000579_abnormal_nail_morphology	0.67138889
84	MP0000703_abnormal_thymus_morphology	0.66861295
85	MP0002075_abnormal_coat/hair_pigmentati	0.66546801
86	MP0001145_abnormal_male_reproductive	0.66065701
87	MP0005670_abnormal_white_adipose	0.61375217
88	MP0000358_abnormal_cell_content/	0.60138877
89	MP0001919_abnormal_reproductive_system	0.59172611
90	MP0002933_joint_inflammation	0.58599943
91	MP0005391_vision/eye_phenotype	0.58547430
92	MP0002184_abnormal_innervation	0.57645299
93	MP0004264_abnormal_extraembryonic_tissu	0.56864056
94	MP0000427_abnormal_hair_cycle	0.56060540
95	MP0001270_distended_abdomen	0.55555009
96	MP0002572_abnormal_emotion/affect_behav	0.55546460
97	MP0000015_abnormal_ear_pigmentation	0.55374143
98	MP0001663_abnormal_digestive_system	0.55271619
99	MP0004134_abnormal_chest_morphology	0.54621957
100	MP0000026_abnormal_inner_ear	0.53585058

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Vitreoretinal degeneration (HP:0000655)	4.76014164
2	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.69290572
3	Dyschromatopsia (HP:0007641)	4.17807989
4	Large eyes (HP:0001090)	3.86757471
5	Pigmentary retinal degeneration (HP:0001146)	3.83222933
6	IgA deficiency (HP:0002720)	3.75581334
7	IgG deficiency (HP:0004315)	3.68207533
8	Abnormal rod and cone electroretinograms (HP:0008323)	3.46686989
9	Oligodactyly (HP:0012165)	3.43538949
10	Agammaglobulinemia (HP:0004432)	3.35448864
11	Rib fusion (HP:0000902)	3.32713345
12	Abnormality of the labia minora (HP:0012880)	3.27904203
13	Increased IgM level (HP:0003496)	3.19079077
14	Oligodactyly (hands) (HP:0001180)	3.10896738
15	Recurrent sinusitis (HP:0011108)	3.05463681
16	Recurrent cutaneous fungal infections (HP:0011370)	2.90417563
17	Chronic mucocutaneous candidiasis (HP:0002728)	2.90417563
18	Abolished electroretinogram (ERG) (HP:0000550)	2.87229303
19	Type II lissencephaly (HP:0007260)	2.85396060
20	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.77952654
21	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.77952654
22	Stenosis of the external auditory canal (HP:0000402)	2.74569217
23	Lissencephaly (HP:0001339)	2.70118097
24	Hepatocellular necrosis (HP:0001404)	2.68790893
25	Hepatic necrosis (HP:0002605)	2.66968197
26	Poor head control (HP:0002421)	2.65054564
27	Medial flaring of the eyebrow (HP:0010747)	2.63387477
28	Cerebellar dysplasia (HP:0007033)	2.60740094
29	IgM deficiency (HP:0002850)	2.58986315
30	Abnormality of T cell physiology (HP:0011840)	2.58874496
31	Intellectual disability, profound (HP:0002187)	2.55005838
32	Recurrent fungal infections (HP:0002841)	2.52779519
33	Hypoplasia of the radius (HP:0002984)	2.52756709
34	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.50485900
35	Abnormality of T cells (HP:0002843)	2.49374264
36	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.48604000
37	Abnormality of cells of the erythroid lineage (HP:0012130)	2.48546386
38	Abnormality of the aortic arch (HP:0012303)	2.48313514
39	Asplenia (HP:0001746)	2.41586454
40	Mitochondrial inheritance (HP:0001427)	2.41449035
41	Panhypogammaglobulinemia (HP:0003139)	2.40961336
42	Molar tooth sign on MRI (HP:0002419)	2.38191707
43	Abnormality of midbrain morphology (HP:0002418)	2.38191707
44	Macrocytic anemia (HP:0001972)	2.36258180
45	Ectopic kidney (HP:0000086)	2.32408561
46	Septo-optic dysplasia (HP:0100842)	2.30846094
47	Congenital primary aphakia (HP:0007707)	2.27805772
48	Horseshoe kidney (HP:0000085)	2.22283090
49	Chronic diarrhea (HP:0002028)	2.22127169
50	Recurrent gram-negative bacterial infections (HP:0005420)	2.21911622
51	Macular degeneration (HP:0000608)	2.20895214
52	Meningitis (HP:0001287)	2.18201516
53	Recurrent bronchitis (HP:0002837)	2.17750003
54	Mediastinal lymphadenopathy (HP:0100721)	2.14783234
55	Gait imbalance (HP:0002141)	2.14319266
56	Nephrogenic diabetes insipidus (HP:0009806)	2.14182283
57	Acute necrotizing encephalopathy (HP:0006965)	2.12743347
58	Increased CSF lactate (HP:0002490)	2.11398292
59	Fair hair (HP:0002286)	2.09014935
60	Growth hormone deficiency (HP:0000824)	2.07075101
61	3-Methylglutaconic aciduria (HP:0003535)	2.06911498
62	Increased hepatocellular lipid droplets (HP:0006565)	2.04511001
63	Lymphopenia (HP:0001888)	2.04306750
64	Forearm undergrowth (HP:0009821)	2.02654739
65	Chronic sinusitis (HP:0011109)	2.02652244
66	Congenital stationary night blindness (HP:0007642)	2.00871528
67	Protruding tongue (HP:0010808)	1.97442661
68	Abnormality of magnesium homeostasis (HP:0004921)	1.96596023
69	Abnormality of abdominal situs (HP:0011620)	1.95873295
70	Abdominal situs inversus (HP:0003363)	1.95873295
71	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.95743842
72	Abnormal mitochondria in muscle tissue (HP:0008316)	1.94961979
73	Aplastic anemia (HP:0001915)	1.93126763
74	Abnormality of cells of the lymphoid lineage (HP:0012140)	1.92932336
75	Facial hemangioma (HP:0000329)	1.92240767
76	Recurrent lower respiratory tract infections (HP:0002783)	1.91107323
77	Cleft eyelid (HP:0000625)	1.90695794
78	Recurrent pneumonia (HP:0006532)	1.88827089
79	Pallor (HP:0000980)	1.88398175
80	Genital tract atresia (HP:0001827)	1.88021467
81	Recurrent viral infections (HP:0004429)	1.85452225
82	Vaginal atresia (HP:0000148)	1.85148550
83	Acute encephalopathy (HP:0006846)	1.84388562
84	Poor coordination (HP:0002370)	1.84230838
85	Eczematoid dermatitis (HP:0000976)	1.80992166
86	Limb hypertonia (HP:0002509)	1.79728196
87	Increased serum lactate (HP:0002151)	1.79534269
88	Deep palmar crease (HP:0006191)	1.78788312
89	Abnormality of T cell number (HP:0011839)	1.78449543
90	Gonadotropin excess (HP:0000837)	1.78148436
91	Severe combined immunodeficiency (HP:0004430)	1.77597018
92	Carpal bone hypoplasia (HP:0001498)	1.77177556
93	Stomatitis (HP:0010280)	1.75908102
94	Supernumerary spleens (HP:0009799)	1.75285307
95	Hyperglycinuria (HP:0003108)	1.75197515
96	Cerebral edema (HP:0002181)	1.74258467
97	Poor speech (HP:0002465)	1.73187752
98	Chronic obstructive pulmonary disease (HP:0006510)	1.72304276
99	Obstructive lung disease (HP:0006536)	1.72304276
100	Pachygyria (HP:0001302)	1.71753080

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK3	4.76499205
2	TAOK3	4.63423908
3	PLK4	3.41996938
4	IRAK4	3.41207119
5	CDK19	3.37759771
6	MAP4K1	3.15928853
7	CDK8	2.64368569
8	ADRBK2	2.34908626
9	MATK	2.33169554
10	MAP3K4	2.20936168
11	TYRO3	2.16562962
12	KDR	2.13804031
13	CCNB1	2.06452355
14	MUSK	1.96665894
15	PASK	1.83613526
16	WNK4	1.69749327
17	SYK	1.66083249
18	BLK	1.61618476
19	EIF2AK3	1.60050563
20	ACVR1B	1.59238187
21	MAP4K2	1.58435454
22	STK38L	1.50771633
23	PRKD3	1.49982963
24	TLK1	1.46630386
25	TESK2	1.43169557
26	CAMKK2	1.38147322
27	ZAK	1.31182106
28	MAP3K14	1.31096932
29	MAP3K12	1.25453257
30	OXSR1	1.20647184
31	LRRK2	1.16820932
32	EPHA4	1.16596765
33	BMPR2	1.14644522
34	CAMKK1	1.12531649
35	STK3	1.11318876
36	VRK2	1.11052383
37	NME2	1.07428674
38	BTK	1.01477209
39	BCKDK	1.01320661
40	MAP2K7	1.01031523
41	TXK	0.99567556
42	LYN	0.96603598
43	BRD4	0.96070706
44	GRK1	0.95378274
45	STK24	0.94617278
46	IKBKE	0.94043577
47	TBK1	0.86641084
48	RIPK4	0.84307230
49	PRKCQ	0.80407125
50	EIF2AK1	0.79851490
51	CSK	0.79172497
52	STK16	0.77620543
53	KIT	0.74796319
54	MAPK7	0.74619067
55	TYK2	0.72153579
56	VRK1	0.70349648
57	DDR2	0.69583972
58	CDC7	0.69320178
59	CSF1R	0.68258688
60	STK39	0.68107762
61	TNK2	0.67455819
62	ITK	0.65369801
63	CHEK2	0.64575322
64	JAK3	0.63120964
65	EPHA3	0.62767357
66	ERBB3	0.60881854
67	FGR	0.59425225
68	IKBKB	0.59319870
69	TEC	0.57493886
70	MAP3K11	0.56052136
71	AURKB	0.55935520
72	MAP2K4	0.55622336
73	AKT2	0.54410792
74	SRPK1	0.53430762
75	PAK6	0.53388745
76	NEK2	0.52630953
77	BCR	0.52200340
78	MST4	0.47870516
79	WNK1	0.46903313
80	PIK3CA	0.45408004
81	NEK9	0.44976222
82	IRAK1	0.44143765
83	ATR	0.42176829
84	CSNK2A2	0.40428281
85	DAPK3	0.38633216
86	PKN1	0.37730358
87	MAPK13	0.37591329
88	RPS6KA5	0.37384373
89	LCK	0.37166740
90	HCK	0.36323086
91	GRK6	0.33862048
92	BRAF	0.32542408
93	CSNK2A1	0.32192149
94	PRKCZ	0.30008414
95	PRKACA	0.27466217
96	NEK1	0.25051525
97	DAPK2	0.24680563
98	PAK1	0.23927518
99	ILK	0.23761346
100	INSRR	0.22704484

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.66245034
2	Allograft rejection_Homo sapiens_hsa05330	4.62476223
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	4.35735820
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	4.25029826
5	Graft-versus-host disease_Homo sapiens_hsa05332	4.03109175
6	Ribosome_Homo sapiens_hsa03010	3.43696269
7	Type I diabetes mellitus_Homo sapiens_hsa04940	3.43694232
8	Primary immunodeficiency_Homo sapiens_hsa05340	2.69532565
9	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.57843022
10	Antigen processing and presentation_Homo sapiens_hsa04612	2.42784107
11	Mismatch repair_Homo sapiens_hsa03430	2.40648375
12	Viral myocarditis_Homo sapiens_hsa05416	2.14883485
13	Oxidative phosphorylation_Homo sapiens_hsa00190	2.11968357
14	Proteasome_Homo sapiens_hsa03050	1.99734617
15	Rheumatoid arthritis_Homo sapiens_hsa05323	1.83741861
16	Parkinsons disease_Homo sapiens_hsa05012	1.71524683
17	Homologous recombination_Homo sapiens_hsa03440	1.68628818
18	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.62462410
19	One carbon pool by folate_Homo sapiens_hsa00670	1.61151757
20	DNA replication_Homo sapiens_hsa03030	1.54013366
21	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.53150650
22	Leishmaniasis_Homo sapiens_hsa05140	1.52594747
23	Nucleotide excision repair_Homo sapiens_hsa03420	1.42192472
24	RNA degradation_Homo sapiens_hsa03018	1.38017808
25	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.19479832
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.16167046
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.13331021
28	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.13061086
29	Basal transcription factors_Homo sapiens_hsa03022	1.07042591
30	Huntingtons disease_Homo sapiens_hsa05016	1.04058109
31	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.03219015
32	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.01092330
33	RNA polymerase_Homo sapiens_hsa03020	1.00681581
34	Regulation of autophagy_Homo sapiens_hsa04140	0.99147311
35	Herpes simplex infection_Homo sapiens_hsa05168	0.98897892
36	Spliceosome_Homo sapiens_hsa03040	0.98444937
37	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.96895104
38	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.93457523
39	Alzheimers disease_Homo sapiens_hsa05010	0.91537451
40	RNA transport_Homo sapiens_hsa03013	0.91500188
41	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.85390886
42	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.85356686
43	Cardiac muscle contraction_Homo sapiens_hsa04260	0.82769417
44	Protein export_Homo sapiens_hsa03060	0.81106400
45	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.78268248
46	Toxoplasmosis_Homo sapiens_hsa05145	0.72680413
47	Influenza A_Homo sapiens_hsa05164	0.72536844
48	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.69494532
49	Phototransduction_Homo sapiens_hsa04744	0.69462222
50	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.68651473
51	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.66884586
52	Tuberculosis_Homo sapiens_hsa05152	0.66349740
53	Measles_Homo sapiens_hsa05162	0.65118615
54	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.64300109
55	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.62572854
56	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.59266390
57	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.55518431
58	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.52267772
59	Phagosome_Homo sapiens_hsa04145	0.52249771
60	Sulfur relay system_Homo sapiens_hsa04122	0.50734813
61	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.49831775
62	HTLV-I infection_Homo sapiens_hsa05166	0.49470338
63	Linoleic acid metabolism_Homo sapiens_hsa00591	0.49414440
64	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.47784153
65	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.42916159
66	Collecting duct acid secretion_Homo sapiens_hsa04966	0.39198012
67	Base excision repair_Homo sapiens_hsa03410	0.35690386
68	Nicotine addiction_Homo sapiens_hsa05033	0.35336945
69	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.34172885
70	Pyrimidine metabolism_Homo sapiens_hsa00240	0.33385733
71	Purine metabolism_Homo sapiens_hsa00230	0.32650718
72	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.32351202
73	Non-homologous end-joining_Homo sapiens_hsa03450	0.32296225
74	Folate biosynthesis_Homo sapiens_hsa00790	0.28996851
75	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.28981373
76	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.28611931
77	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.28008862
78	Chemokine signaling pathway_Homo sapiens_hsa04062	0.26275743
79	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.24390054
80	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.22801096
81	Tryptophan metabolism_Homo sapiens_hsa00380	0.22783166
82	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.21060909
83	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.20653288
84	Chemical carcinogenesis_Homo sapiens_hsa05204	0.19612544
85	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.18628734
86	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.16946934
87	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.15336595
88	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.15158789
89	mRNA surveillance pathway_Homo sapiens_hsa03015	0.14971494
90	Salmonella infection_Homo sapiens_hsa05132	0.14668300
91	Glutamatergic synapse_Homo sapiens_hsa04724	0.14464168
92	Sulfur metabolism_Homo sapiens_hsa00920	0.14330579
93	Alcoholism_Homo sapiens_hsa05034	0.13606472
94	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.13446206
95	Legionellosis_Homo sapiens_hsa05134	0.12727554
96	Olfactory transduction_Homo sapiens_hsa04740	0.12362106
97	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.12283806
98	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.12045351
99	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.11505421
100	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.11038775

COX20P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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