COX4I1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Pseudogenes related to this gene are located on chromosomes 13 and 14. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ATP synthesis coupled proton transport (GO:0015986)9.58212139
2energy coupled proton transport, down electrochemical gradient (GO:0015985)9.58212139
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)8.50971468
4* respiratory electron transport chain (GO:0022904)8.23391207
5* electron transport chain (GO:0022900)8.03297853
6oxidative phosphorylation (GO:0006119)6.87380012
7tricarboxylic acid cycle (GO:0006099)6.46768255
8ATP biosynthetic process (GO:0006754)5.76823638
9nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.59703649
10translational initiation (GO:0006413)5.39608189
11NADH metabolic process (GO:0006734)5.27966254
12maturation of SSU-rRNA (GO:0030490)5.15811310
13purine ribonucleoside triphosphate biosynthetic process (GO:0009206)5.04059420
14chaperone-mediated protein transport (GO:0072321)5.01845030
15ribosomal large subunit biogenesis (GO:0042273)5.00932313
16purine nucleoside triphosphate biosynthetic process (GO:0009145)4.98022688
17* hydrogen ion transmembrane transport (GO:1902600)4.86832861
18protein complex disassembly (GO:0043241)4.86495919
19inner mitochondrial membrane organization (GO:0007007)4.76156840
20protein complex biogenesis (GO:0070271)4.72783947
21macromolecular complex disassembly (GO:0032984)4.62420702
22mitochondrial respiratory chain complex I assembly (GO:0032981)4.61883669
23NADH dehydrogenase complex assembly (GO:0010257)4.61883669
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.61883669
25protein targeting to membrane (GO:0006612)4.58724097
26ribonucleoside triphosphate biosynthetic process (GO:0009201)4.51240066
27mitochondrial respiratory chain complex assembly (GO:0033108)4.46588589
28aerobic respiration (GO:0009060)4.26582830
29establishment of protein localization to mitochondrial membrane (GO:0090151)4.19283911
30sarcomere organization (GO:0045214)4.18787698
31succinate metabolic process (GO:0006105)4.18670440
32* proton transport (GO:0015992)4.18374011
33* hydrogen transport (GO:0006818)4.12126793
34negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.00549377
35regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.98457326
36nucleoside triphosphate biosynthetic process (GO:0009142)3.96005323
37regulation of acyl-CoA biosynthetic process (GO:0050812)3.89593060
38purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.86940284
39purine nucleoside monophosphate biosynthetic process (GO:0009127)3.86940284
40protein neddylation (GO:0045116)3.83082035
41viral transcription (GO:0019083)3.80318510
42nuclear-transcribed mRNA catabolic process (GO:0000956)3.78361854
43regulation of mitochondrial translation (GO:0070129)3.78084913
44quinone biosynthetic process (GO:1901663)3.78021800
45ubiquinone biosynthetic process (GO:0006744)3.78021800
46regulation of oxidative phosphorylation (GO:0002082)3.77954086
47cellular component biogenesis (GO:0044085)3.76884592
48regulation of cofactor metabolic process (GO:0051193)3.75454846
49regulation of coenzyme metabolic process (GO:0051196)3.75454846
50positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.73390793
51mitochondrial transport (GO:0006839)3.73162148
52positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.69219371
53negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.68327684
54negative regulation of ligase activity (GO:0051352)3.68327684
55oxaloacetate metabolic process (GO:0006107)3.67590176
56DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.64693155
57transcription elongation from RNA polymerase III promoter (GO:0006385)3.64457131
58termination of RNA polymerase III transcription (GO:0006386)3.64457131
59translational termination (GO:0006415)3.61598924
60mRNA catabolic process (GO:0006402)3.58516491
61regulation of cellular respiration (GO:0043457)3.57250486
62regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.54165262
63ribonucleoprotein complex biogenesis (GO:0022613)3.53853525
64heart contraction (GO:0060047)3.52986914
65heart process (GO:0003015)3.52986914
66intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.51824165
67signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.51824165
68ribosomal small subunit assembly (GO:0000028)3.51511884
69signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.50141258
70signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.50141258
71signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.50141258
72muscle filament sliding (GO:0030049)3.43197698
73actin-myosin filament sliding (GO:0033275)3.43197698
74signal transduction involved in DNA damage checkpoint (GO:0072422)3.39921861
75signal transduction involved in DNA integrity checkpoint (GO:0072401)3.39921861
76establishment of protein localization to membrane (GO:0090150)3.39802616
77ATP hydrolysis coupled proton transport (GO:0015991)3.39117702
78energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.39117702
79protein targeting to mitochondrion (GO:0006626)3.35367351
80formation of translation preinitiation complex (GO:0001731)3.35297149
81anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.35269237
82* generation of precursor metabolites and energy (GO:0006091)3.35055097
83ubiquinone metabolic process (GO:0006743)3.34924533
84translational elongation (GO:0006414)3.34533840
85deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.33148059
86signal transduction involved in cell cycle checkpoint (GO:0072395)3.32958856
87ribosomal small subunit biogenesis (GO:0042274)3.32878163
88regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.32697497
89establishment of protein localization to mitochondrion (GO:0072655)3.31901573
90cellular respiration (GO:0045333)3.31378916
91intracellular protein transmembrane import (GO:0044743)3.30760615
92protein targeting (GO:0006605)3.28115100
93protein localization to mitochondrion (GO:0070585)3.26866755
94negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.25850845
95regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.24902294
96RNA catabolic process (GO:0006401)3.24479226
97cardiac muscle contraction (GO:0060048)3.23546224
98positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.22753438
99cotranslational protein targeting to membrane (GO:0006613)3.22732349
100SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.22058350
101respiratory chain complex IV assembly (GO:0008535)3.20997368
102purine nucleoside biosynthetic process (GO:0042451)3.20681216
103purine ribonucleoside biosynthetic process (GO:0046129)3.20681216
104sequestering of actin monomers (GO:0042989)3.20109037
105protein targeting to ER (GO:0045047)3.19177536
106cytochrome complex assembly (GO:0017004)3.17360651
107ribonucleoside monophosphate biosynthetic process (GO:0009156)3.17092009
108aspartate family amino acid catabolic process (GO:0009068)3.11873216
109regulation of relaxation of muscle (GO:1901077)3.10621499
110negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.10118261
111cardiac myofibril assembly (GO:0055003)3.09827086
112branched-chain amino acid catabolic process (GO:0009083)3.08792064
113protein localization to endoplasmic reticulum (GO:0070972)3.08147610
114GTP biosynthetic process (GO:0006183)3.07149136
115establishment of protein localization to endoplasmic reticulum (GO:0072599)3.06911743
116positive regulation of ligase activity (GO:0051351)3.06814143
117regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.05307186
118regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.00770542
119regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.00720025
120nucleoside monophosphate biosynthetic process (GO:0009124)2.98455488
121negative regulation of potassium ion transmembrane transport (GO:1901380)2.98320366
122antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.97186779
123cullin deneddylation (GO:0010388)2.95631102
124regulation of cellular amino acid metabolic process (GO:0006521)2.95519598
125cellular protein complex disassembly (GO:0043624)2.95188428
126regulation of cell communication by electrical coupling (GO:0010649)2.94825800
127regulation of cellular amine metabolic process (GO:0033238)2.93851043
128fatty acid beta-oxidation (GO:0006635)2.93695847
129rRNA modification (GO:0000154)2.93371377
130aldehyde catabolic process (GO:0046185)2.92352261
131viral life cycle (GO:0019058)2.89243359
132L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.88879936
1332-oxoglutarate metabolic process (GO:0006103)2.87821156
134mitochondrial fusion (GO:0008053)2.87255741
135tricarboxylic acid metabolic process (GO:0072350)2.85088857
136lysine metabolic process (GO:0006553)2.84453615
137lysine catabolic process (GO:0006554)2.84453615
138proteasome assembly (GO:0043248)2.83751457
139translation (GO:0006412)2.81775066
140myofibril assembly (GO:0030239)2.80127674
141regulation of actin filament-based movement (GO:1903115)2.77850052
142ribonucleoside biosynthetic process (GO:0042455)2.76772129
143mitochondrial ATP synthesis coupled proton transport (GO:0042776)10.3333803

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.58783883
2* ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.31888542
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.25250231
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.91805632
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.56625217
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.47422552
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.32935178
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.24930720
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.17762683
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.16138913
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.12725705
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.12125303
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.99421354
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.91045530
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.54458056
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.53308586
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.47303318
18* SRF_21415370_ChIP-Seq_HL-1_Mouse2.43544213
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.38220853
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.36004772
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.35500215
22YY1_21170310_ChIP-Seq_MESCs_Mouse2.26313452
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.25388908
24CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.19527048
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.17587946
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.07483339
27DCP1A_22483619_ChIP-Seq_HELA_Human2.01253990
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.95908426
29XRN2_22483619_ChIP-Seq_HELA_Human1.92664610
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87213491
31ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.84380741
32NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.82843025
33* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.74095821
34HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.69347510
35SRY_22984422_ChIP-ChIP_TESTIS_Rat1.68200533
36BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.64500361
37CTCF_18555785_ChIP-Seq_MESCs_Mouse1.60763474
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.54733671
39ZNF263_19887448_ChIP-Seq_K562_Human1.52994362
40GABP_19822575_ChIP-Seq_HepG2_Human1.51691240
41VDR_23849224_ChIP-Seq_CD4+_Human1.51289175
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42472281
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.42226448
44TTF2_22483619_ChIP-Seq_HELA_Human1.41012498
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.35980987
46YY1_22570637_ChIP-Seq_MALME-3M_Human1.35681185
47CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.34419826
48ELK1_22589737_ChIP-Seq_MCF10A_Human1.33586028
49* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.32536616
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29603185
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25847215
52OCT4_18692474_ChIP-Seq_MEFs_Mouse1.24864362
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24710075
54SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24508264
55FOXP3_21729870_ChIP-Seq_TREG_Human1.24438927
56CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24032255
57SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23489338
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22744769
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.20958234
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20447290
61FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.20238811
62KDM5A_27292631_Chip-Seq_BREAST_Human1.19590345
63SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.19530711
64EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.17455235
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16731821
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15727225
67MYC_18940864_ChIP-ChIP_HL60_Human1.13815882
68KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13622958
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13188118
70* TET1_21451524_ChIP-Seq_MESCs_Mouse1.12656069
71BCL6_27268052_Chip-Seq_Bcells_Human1.11910452
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11299290
73* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08621066
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08272316
75E2F4_17652178_ChIP-ChIP_JURKAT_Human1.07055307
76TBX5_21415370_ChIP-Seq_HL-1_Mouse1.03489041
77* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03065287
78MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01988519
79HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01888003
80NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98132606
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97725681
82* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97348356
83FOXP1_21924763_ChIP-Seq_HESCs_Human0.96743225
84ELF1_20517297_ChIP-Seq_JURKAT_Human0.96164734
85FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94800411
86SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94328406
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93916853
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93488401
89ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92573609
90ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91956388
91RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91802399
92BCOR_27268052_Chip-Seq_Bcells_Human0.91360830
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91305177
94CTCF_26484167_Chip-Seq_Bcells_Mouse0.91156473
95RAD21_21589869_ChIP-Seq_MESCs_Mouse0.90455027
96CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.88113593
97HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87922345
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87558535
99* MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.86949492
100PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.86938197
101CIITA_25753668_ChIP-Seq_RAJI_Human0.85068581
102MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.84586939
103ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.84429438
104NANOG_20526341_ChIP-Seq_ESCs_Human0.83144621
105CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.82935435
106CTCF_20526341_ChIP-Seq_ESCs_Human0.82895081
107* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.82884964
108P68_20966046_ChIP-Seq_HELA_Human0.82584280
109SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.82533483
110ELK1_19687146_ChIP-ChIP_HELA_Human0.81102861
111BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.80883081
112PADI4_21655091_ChIP-ChIP_MCF-7_Human0.80706498
113TAF2_19829295_ChIP-Seq_ESCs_Human0.80193454
114RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79979402
115PPARA_22158963_ChIP-Seq_LIVER_Mouse0.79578527
116SA1_27219007_Chip-Seq_Bcells_Human0.79440478
117DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79388985
118PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78606607
119SMC3_22415368_ChIP-Seq_MEFs_Mouse0.78100942
120SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.77569783
121E2F1_20622854_ChIP-Seq_HELA_Human0.76620903
122SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.75547807
123* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.73869939
124* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72290248
125MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.70749022

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.70479924
2MP0003646_muscle_fatigue4.63493022
3MP0000751_myopathy4.07388521
4MP0004084_abnormal_cardiac_muscle3.91712843
5MP0006036_abnormal_mitochondrial_physio3.81330468
6MP0004215_abnormal_myocardial_fiber3.72932472
7MP0000749_muscle_degeneration3.24652138
8MP0005330_cardiomyopathy3.18005464
9MP0004036_abnormal_muscle_relaxation3.17406283
10MP0003806_abnormal_nucleotide_metabolis3.04196312
11MP0000372_irregular_coat_pigmentation2.64895217
12MP0006035_abnormal_mitochondrial_morpho2.62503584
13MP0003137_abnormal_impulse_conducting2.37048674
14MP0001529_abnormal_vocalization2.34968407
15MP0002972_abnormal_cardiac_muscle2.32255983
16MP0008775_abnormal_heart_ventricle2.28267289
17MP0004043_abnormal_pH_regulation2.17004446
18MP0003186_abnormal_redox_activity2.15064535
19MP0000750_abnormal_muscle_regeneration2.11318409
20MP0004087_abnormal_muscle_fiber2.01153438
21MP0004130_abnormal_muscle_cell1.94350716
22MP0005620_abnormal_muscle_contractility1.93816548
23MP0001544_abnormal_cardiovascular_syste1.90474205
24MP0005385_cardiovascular_system_phenoty1.90474205
25MP0003123_paternal_imprinting1.81671436
26MP0003011_delayed_dark_adaptation1.81519637
27MP0002106_abnormal_muscle_physiology1.79699969
28MP0002822_catalepsy1.78844121
29MP0008995_early_reproductive_senescence1.78761674
30MP0003221_abnormal_cardiomyocyte_apopto1.77950505
31MP0008058_abnormal_DNA_repair1.72165145
32MP0002269_muscular_atrophy1.72159100
33MP0000747_muscle_weakness1.68253895
34MP0004957_abnormal_blastocyst_morpholog1.66711330
35MP0003136_yellow_coat_color1.65999921
36MP0004484_altered_response_of1.65586083
37MP0005423_abnormal_somatic_nervous1.60024851
38MP0006138_congestive_heart_failure1.59803732
39MP0002332_abnormal_exercise_endurance1.57521293
40MP0003693_abnormal_embryo_hatching1.57195403
41MP0009379_abnormal_foot_pigmentation1.56823950
42MP0002938_white_spotting1.53735856
43MP0005332_abnormal_amino_acid1.52223542
44MP0004270_analgesia1.50308635
45MP0004085_abnormal_heartbeat1.49095022
46MP0004145_abnormal_muscle_electrophysio1.48279041
47MP0004147_increased_porphyrin_level1.47691997
48MP0003880_abnormal_central_pattern1.42472617
49MP0005266_abnormal_metabolism1.42009811
50MP0005369_muscle_phenotype1.38872267
51MP0000759_abnormal_skeletal_muscle1.37922310
52MP0004142_abnormal_muscle_tone1.36744612
53MP0003786_premature_aging1.35925133
54MP0001905_abnormal_dopamine_level1.34008449
55MP0000013_abnormal_adipose_tissue1.32489459
56MP0003195_calcinosis1.31138542
57MP0010630_abnormal_cardiac_muscle1.29349986
58MP0002277_abnormal_respiratory_mucosa1.29248155
59MP0005584_abnormal_enzyme/coenzyme_acti1.27784464
60MP0001984_abnormal_olfaction1.21507231
61MP0002736_abnormal_nociception_after1.18845190
62MP0005408_hypopigmentation1.18680574
63MP0006276_abnormal_autonomic_nervous1.18020292
64MP0004742_abnormal_vestibular_system1.16883594
65MP0005535_abnormal_body_temperature1.15640749
66MP0005636_abnormal_mineral_homeostasis1.15074383
67MP0005075_abnormal_melanosome_morpholog1.14451246
68MP0002163_abnormal_gland_morphology1.14368792
69MP0005083_abnormal_biliary_tract1.13265650
70MP0005165_increased_susceptibility_to1.09254318
71MP0005666_abnormal_adipose_tissue1.08190158
72MP0002272_abnormal_nervous_system1.07920818
73MP0004233_abnormal_muscle_weight1.07461475
74MP0009046_muscle_twitch1.07437105
75MP0002638_abnormal_pupillary_reflex1.06839555
76MP0006072_abnormal_retinal_apoptosis1.06706898
77MP0005379_endocrine/exocrine_gland_phen1.06698375
78MP0000230_abnormal_systemic_arterial1.05677039
79MP0004019_abnormal_vitamin_homeostasis1.03019365
80MP0009643_abnormal_urine_homeostasis1.01687392
81MP0000343_altered_response_to0.99666423
82MP0001986_abnormal_taste_sensitivity0.99580848
83MP0005360_urolithiasis0.99303691
84MP0005670_abnormal_white_adipose0.98603320
85MP0002064_seizures0.97406619
86MP0008872_abnormal_physiological_respon0.97258179
87MP0004924_abnormal_behavior0.96751987
88MP0005386_behavior/neurological_phenoty0.96751987
89MP0001440_abnormal_grooming_behavior0.95633412
90MP0005451_abnormal_body_composition0.94880580
91MP0000358_abnormal_cell_content/0.94738207
92MP0002572_abnormal_emotion/affect_behav0.92879461
93MP0006292_abnormal_olfactory_placode0.92531774
94MP0009840_abnormal_foam_cell0.92305937
95MP0001756_abnormal_urination0.92182149
96MP0003718_maternal_effect0.92131098
97MP0002132_abnormal_respiratory_system0.91917658
98MP0001853_heart_inflammation0.91716422
99MP0002095_abnormal_skin_pigmentation0.89642764
100MP0001727_abnormal_embryo_implantation0.89238129
101MP0005319_abnormal_enzyme/_coenzyme0.89084787
102MP0002067_abnormal_sensory_capabilities0.88867739
103MP0003656_abnormal_erythrocyte_physiolo0.88402696
104MP0002909_abnormal_adrenal_gland0.88303293
105MP0001968_abnormal_touch/_nociception0.87595120
106MP0001970_abnormal_pain_threshold0.85948575
107MP0008569_lethality_at_weaning0.85304482
108MP0005085_abnormal_gallbladder_physiolo0.85124315
109MP0009745_abnormal_behavioral_response0.83347399
110MP0002090_abnormal_vision0.82831983
111MP0002735_abnormal_chemical_nociception0.82744696
112MP0003879_abnormal_hair_cell0.82070490
113MP0002127_abnormal_cardiovascular_syste0.82031353
114MP0005376_homeostasis/metabolism_phenot0.81619530
115MP0001486_abnormal_startle_reflex0.81201461
116MP0002063_abnormal_learning/memory/cond0.81127246
117MP0001764_abnormal_homeostasis0.80846656
118MP0002557_abnormal_social/conspecific_i0.80403610
119MP0005551_abnormal_eye_electrophysiolog0.80234446
120MP0003787_abnormal_imprinting0.78044263
121MP0008004_abnormal_stomach_pH0.75948960
122MP0003638_abnormal_response/metabolism_0.75910130
123MP0003122_maternal_imprinting0.75528247
124MP0003828_pulmonary_edema0.75099209
125MP0002066_abnormal_motor_capabilities/c0.74366768
126MP0003329_amyloid_beta_deposits0.73629960
127MP0005365_abnormal_bile_salt0.72988673
128MP0002876_abnormal_thyroid_physiology0.72783933
129MP0003077_abnormal_cell_cycle0.72443287
130MP0005410_abnormal_fertilization0.71820486
131MP0002734_abnormal_mechanical_nocicepti0.71795055
132MP0002139_abnormal_hepatobiliary_system0.71144522
133MP0003635_abnormal_synaptic_transmissio0.70526541
134MP0008932_abnormal_embryonic_tissue0.70315990
135MP0001765_abnormal_ion_homeostasis0.69557801
136MP0002733_abnormal_thermal_nociception0.68937150
137MP0005084_abnormal_gallbladder_morpholo0.67164724
138MP0004859_abnormal_synaptic_plasticity0.67126695
139MP0001664_abnormal_digestion0.66921711
140MP0001485_abnormal_pinna_reflex0.66254748
141MP0004510_myositis0.64925413
142MP0008875_abnormal_xenobiotic_pharmacok0.64379037
143MP0005375_adipose_tissue_phenotype0.62418367
144MP0005377_hearing/vestibular/ear_phenot0.62159060
145MP0003878_abnormal_ear_physiology0.62159060
146MP0002078_abnormal_glucose_homeostasis0.59961958
147MP0005058_abnormal_lysosome_morphology0.59411299

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.91309997
2Abnormal mitochondria in muscle tissue (HP:0008316)6.63822051
3Acute encephalopathy (HP:0006846)6.10000141
4Mitochondrial inheritance (HP:0001427)6.06393928
5Hepatocellular necrosis (HP:0001404)5.82207442
6Hepatic necrosis (HP:0002605)5.72024541
7Progressive macrocephaly (HP:0004481)5.68912547
8Increased CSF lactate (HP:0002490)5.43554092
9Cerebral edema (HP:0002181)4.69203426
10Reticulocytopenia (HP:0001896)4.59446394
11Macrocytic anemia (HP:0001972)4.26003629
12Increased muscle lipid content (HP:0009058)4.21817757
13Sudden death (HP:0001699)4.21677783
14Lactic acidosis (HP:0003128)4.20944374
15Increased intramyocellular lipid droplets (HP:0012240)4.19904667
16Increased serum pyruvate (HP:0003542)4.19255175
17Abnormality of glycolysis (HP:0004366)4.19255175
18Respiratory failure (HP:0002878)4.14934171
19Decreased activity of mitochondrial respiratory chain (HP:0008972)4.08742791
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.08742791
21Lipid accumulation in hepatocytes (HP:0006561)4.05544546
22Increased hepatocellular lipid droplets (HP:0006565)3.99633356
23Exercise intolerance (HP:0003546)3.92294579
24Palpitations (HP:0001962)3.63787937
25Increased serum lactate (HP:0002151)3.60847627
26Pheochromocytoma (HP:0002666)3.60121755
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.55221624
28Neuroendocrine neoplasm (HP:0100634)3.51303434
29Myoglobinuria (HP:0002913)3.51128399
30Leukodystrophy (HP:0002415)3.32375564
31Ventricular tachycardia (HP:0004756)3.20691632
32Calf muscle hypertrophy (HP:0008981)3.18191614
33Optic disc pallor (HP:0000543)3.14994252
34Renal Fanconi syndrome (HP:0001994)3.12595992
35Exercise-induced muscle cramps (HP:0003710)3.10157324
36Rhabdomyolysis (HP:0003201)3.09893500
37Abnormality of dicarboxylic acid metabolism (HP:0010995)3.08691350
38Dicarboxylic aciduria (HP:0003215)3.08691350
39Exercise-induced myalgia (HP:0003738)3.08529097
40Muscle hypertrophy of the lower extremities (HP:0008968)3.00715349
41Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.97202557
42Abnormality of fatty-acid metabolism (HP:0004359)2.96016273
43Pallor (HP:0000980)2.92984979
44CNS demyelination (HP:0007305)2.90451344
45Conjunctival hamartoma (HP:0100780)2.89214661
46Lethargy (HP:0001254)2.86467478
47Muscle fiber splitting (HP:0003555)2.72309903
48Lipoatrophy (HP:0100578)2.68948175
49Emotional lability (HP:0000712)2.65264993
503-Methylglutaconic aciduria (HP:0003535)2.64452296
51Ragged-red muscle fibers (HP:0003200)2.63866615
52Abnormality of cells of the erythroid lineage (HP:0012130)2.61284831
53Myotonia (HP:0002486)2.59334883
54Myokymia (HP:0002411)2.57765192
55Exertional dyspnea (HP:0002875)2.54532392
56Atrial fibrillation (HP:0005110)2.54245189
57Ketoacidosis (HP:0001993)2.49883559
58Syncope (HP:0001279)2.49533624
59Supraventricular tachycardia (HP:0004755)2.48541260
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.48401487
61Abnormality of alanine metabolism (HP:0010916)2.48401487
62Hyperalaninemia (HP:0003348)2.48401487
63Glycosuria (HP:0003076)2.47978395
64Abnormality of urine glucose concentration (HP:0011016)2.47978395
65Generalized aminoaciduria (HP:0002909)2.47149201
66Abnormality of the calf musculature (HP:0001430)2.44686658
67Supraventricular arrhythmia (HP:0005115)2.42312390
68Esophageal neoplasm (HP:0100751)2.41773009
69Neoplasm of head and neck (HP:0012288)2.41773009
70Respiratory difficulties (HP:0002880)2.41744597
71Primary atrial arrhythmia (HP:0001692)2.40672228
72Ventricular fibrillation (HP:0001663)2.40426344
73Dilated cardiomyopathy (HP:0001644)2.38856005
74Cerebral hypomyelination (HP:0006808)2.38602360
75Microvesicular hepatic steatosis (HP:0001414)2.37494578
76Muscle stiffness (HP:0003552)2.37375529
77Abnormal number of erythroid precursors (HP:0012131)2.36765805
78Multiple enchondromatosis (HP:0005701)2.34405680
79Vomiting (HP:0002013)2.34193112
80Prolonged QT interval (HP:0001657)2.33936223
81Aplasia/Hypoplasia of the sacrum (HP:0008517)2.29946365
82Neoplasm of the adrenal gland (HP:0100631)2.24941310
83Methylmalonic aciduria (HP:0012120)2.22652005
84Hyperglycinuria (HP:0003108)2.21563165
85Hypoglycemic coma (HP:0001325)2.18963445
86Cholecystitis (HP:0001082)2.18077610
87Abnormal gallbladder physiology (HP:0012438)2.18077610
88Type I transferrin isoform profile (HP:0003642)2.17496106
89X-linked dominant inheritance (HP:0001423)2.16873401
90Nausea (HP:0002018)2.13996963
91EMG: myopathic abnormalities (HP:0003458)2.08177751
92Gliosis (HP:0002171)2.08094010
93Ventricular arrhythmia (HP:0004308)2.08021022
94Hyperammonemia (HP:0001987)2.07837754
95Ketosis (HP:0001946)2.06524656
96Bundle branch block (HP:0011710)2.06043743
97Neoplasm of the peripheral nervous system (HP:0100007)2.04067834
98Abnormality of renal resorption (HP:0011038)2.01892686
99Proximal tubulopathy (HP:0000114)2.01815109
100Cerebral hemorrhage (HP:0001342)2.00186735
101Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.00126259
102Aplastic anemia (HP:0001915)1.98996602
103Abnormality of aromatic amino acid family metabolism (HP:0004338)1.98556096
104Abnormality of the vocal cords (HP:0008777)1.94776663
105Metabolic acidosis (HP:0001942)1.92741244
106Abnormal urine phosphate concentration (HP:0012599)1.92464107
107Hyperphosphaturia (HP:0003109)1.91225010
108Abnormality of glycine metabolism (HP:0010895)1.89963941
109Abnormality of serine family amino acid metabolism (HP:0010894)1.89963941
110Abnormality of the anterior horn cell (HP:0006802)1.89696452
111Degeneration of anterior horn cells (HP:0002398)1.89696452
112Testicular atrophy (HP:0000029)1.87900870
113Right ventricular cardiomyopathy (HP:0011663)1.87501830
114Oral leukoplakia (HP:0002745)1.86007941
115Methylmalonic acidemia (HP:0002912)1.83063432
116Blindness (HP:0000618)1.81339720
117Poor suck (HP:0002033)1.80257880
118CNS hypomyelination (HP:0003429)1.78301854
119Hyperglycinemia (HP:0002154)1.71864642
120Renal tubular dysfunction (HP:0000124)1.70235929
121Pancytopenia (HP:0001876)1.68367917
122Dysphonia (HP:0001618)1.65264492
123Congenital, generalized hypertrichosis (HP:0004540)1.64938720
124Abnormality of reticulocytes (HP:0004312)1.64208943
125Gout (HP:0001997)1.63039878
126Progressive muscle weakness (HP:0003323)1.59850362
127Unsteady gait (HP:0002317)1.59641675
128Opisthotonus (HP:0002179)1.57269278
129Limb dystonia (HP:0002451)1.56564834
130Concave nail (HP:0001598)1.55645423
131Abnormal protein N-linked glycosylation (HP:0012347)1.54845836
132Abnormal protein glycosylation (HP:0012346)1.54845836
133Abnormal glycosylation (HP:0012345)1.54845836
134Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.54845836
135Sparse eyelashes (HP:0000653)1.52824577
136Abnormality of serum amino acid levels (HP:0003112)1.52657352
137Progressive microcephaly (HP:0000253)1.50465468
138Focal motor seizures (HP:0011153)1.49664174

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.52439132
2MYLK3.82811958
3NME23.61989534
4BCKDK3.59721682
5PDK42.89470202
6PDK32.89470202
7LMTK22.86986704
8OBSCN2.85967864
9NME12.84734941
10NEK12.78854436
11ARAF2.78450954
12MAP3K122.69005832
13WNK42.31276267
14LIMK12.15874879
15PHKG22.13647868
16PHKG12.13647868
17TTN2.00153760
18STK161.93421940
19TESK21.86573604
20PDK21.86296629
21STK391.76006159
22PINK11.71351940
23ILK1.64656776
24DAPK31.63034941
25BUB11.62562197
26MUSK1.57712169
27PBK1.56878232
28TESK11.56655469
29MAP3K111.55405448
30OXSR11.54460497
31EIF2AK11.53880722
32PIM21.52381513
33PASK1.46033616
34CDK191.34630718
35MST41.29861866
36GRK71.18966202
37PIK3CA1.18845899
38GRK51.17822827
39CDC71.14307740
40PKN21.11685650
41CAMK2D1.11002870
42WNK31.09052668
43SRPK11.07570162
44ABL21.04860768
45MAPKAPK31.04696177
46BRAF1.03360534
47TLK11.01125760
48LRRK20.94764163
49KDR0.93055386
50CCNB10.90375499
51CAMK2G0.86015899
52PTK2B0.84690980
53BCR0.80023076
54CSNK2A20.79817897
55WEE10.79383059
56VRK10.76400893
57TRIB30.76103466
58MAP4K20.75545287
59DAPK10.74329859
60ROCK20.70686036
61PAK30.70478022
62TIE10.68511077
63MINK10.66925422
64STK40.65503494
65KSR20.65162478
66PLK30.63662689
67CAMK2A0.62935626
68AURKB0.62280935
69TTK0.61525272
70CSNK1G30.61085737
71UHMK10.60277765
72CAMK2B0.59747780
73RPS6KA50.59744176
74EPHB20.58613561
75BRSK10.57810472
76STK240.57149529
77PRKCI0.55538858
78EIF2AK30.54657287
79ROCK10.54003142
80STK38L0.52982608
81MST1R0.52951483
82RAF10.52941122
83DMPK0.52192301
84PLK10.50121993
85MAP2K10.49856242
86TRIM280.48173038
87RPS6KB20.47394347
88PAK10.47359356
89MAP2K70.47043553
90PRKACA0.46822527
91CSNK1G20.45723976
92ADRBK10.43533237
93AURKA0.43226314
94MAP2K20.43123372
95TSSK60.43038916
96ALK0.43006878
97CDK140.42755010
98GRK10.41196847
99PAK40.40252037
100PRKD10.39007663
101PAK60.38266111
102FLT30.37968672
103CAMKK20.37656034
104NTRK30.36933670
105CSNK1E0.36357488
106AKT20.36177034
107ADRBK20.34916498
108CDK180.34893084
109PDPK10.34860821
110CAMK10.34807848
111PRKCA0.34094736
112ZAK0.33948096
113DAPK20.33474289
114CSNK1G10.33090287
115CDK80.32833340
116CDK150.32732559
117MAP3K90.32730912
118SCYL20.32636079
119CDK11A0.32286139
120MAPK120.31747913
121INSRR0.30938203
122CSNK1A10.30517164
123DYRK20.30265316
124PRKACG0.29798817
125PRKG20.28838753
126MAP2K60.28189300
127PRKACB0.27672257
128PRKCE0.27597291
129MAPKAPK50.27338051
130PIK3CG0.26824793
131PRKCD0.25785875
132PRKCG0.25156838
133MAP2K40.24107687
134PLK20.23843468
135CSNK2A10.23821122
136EPHA40.22984637

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001905.89543184
2Parkinsons disease_Homo sapiens_hsa050125.29425336
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.67099878
4Alzheimers disease_Homo sapiens_hsa050103.77268653
5Huntingtons disease_Homo sapiens_hsa050163.53909204
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.31313476
7* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.28339072
8* Cardiac muscle contraction_Homo sapiens_hsa042603.27567479
9Ribosome_Homo sapiens_hsa030103.00192579
10Proteasome_Homo sapiens_hsa030502.75073650
11Propanoate metabolism_Homo sapiens_hsa006402.51895250
12Carbon metabolism_Homo sapiens_hsa012002.26932117
13Pyruvate metabolism_Homo sapiens_hsa006202.18553423
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02864521
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.84977312
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.84318796
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82497406
18Fatty acid degradation_Homo sapiens_hsa000711.79583250
19Fatty acid elongation_Homo sapiens_hsa000621.67530053
20Collecting duct acid secretion_Homo sapiens_hsa049661.52999601
21Butanoate metabolism_Homo sapiens_hsa006501.52778654
22Fatty acid metabolism_Homo sapiens_hsa012121.43157841
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.32679045
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25399338
25Biosynthesis of amino acids_Homo sapiens_hsa012301.19701364
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17572230
27Sulfur metabolism_Homo sapiens_hsa009201.16376896
28RNA polymerase_Homo sapiens_hsa030201.14454632
29Base excision repair_Homo sapiens_hsa034101.06374936
30Fructose and mannose metabolism_Homo sapiens_hsa000510.97529809
31Peroxisome_Homo sapiens_hsa041460.95227359
32Vibrio cholerae infection_Homo sapiens_hsa051100.93365945
33Protein export_Homo sapiens_hsa030600.91473903
34Glutathione metabolism_Homo sapiens_hsa004800.87868850
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87035627
36* Metabolic pathways_Homo sapiens_hsa011000.86201789
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83679041
38beta-Alanine metabolism_Homo sapiens_hsa004100.80884078
39Cysteine and methionine metabolism_Homo sapiens_hsa002700.80315700
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80119150
41Synaptic vesicle cycle_Homo sapiens_hsa047210.79326859
42Pentose phosphate pathway_Homo sapiens_hsa000300.78620929
43Phenylalanine metabolism_Homo sapiens_hsa003600.76892725
44Pyrimidine metabolism_Homo sapiens_hsa002400.75900672
45Sulfur relay system_Homo sapiens_hsa041220.74643717
46Arginine and proline metabolism_Homo sapiens_hsa003300.73912991
47Dilated cardiomyopathy_Homo sapiens_hsa054140.73704012
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72835593
49RNA degradation_Homo sapiens_hsa030180.72799554
50One carbon pool by folate_Homo sapiens_hsa006700.71454983
51Galactose metabolism_Homo sapiens_hsa000520.70826719
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69760469
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67565361
54Tyrosine metabolism_Homo sapiens_hsa003500.66288165
55RNA transport_Homo sapiens_hsa030130.63153268
56PPAR signaling pathway_Homo sapiens_hsa033200.63132686
57Tryptophan metabolism_Homo sapiens_hsa003800.57774810
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55947611
59Nitrogen metabolism_Homo sapiens_hsa009100.55409138
60Folate biosynthesis_Homo sapiens_hsa007900.53101692
61Vitamin B6 metabolism_Homo sapiens_hsa007500.51351713
62Basal transcription factors_Homo sapiens_hsa030220.50686555
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.48646323
64Starch and sucrose metabolism_Homo sapiens_hsa005000.44301578
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43372061
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43366636
67Arginine biosynthesis_Homo sapiens_hsa002200.41698032
68Purine metabolism_Homo sapiens_hsa002300.41592051
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38148066
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37046315
71DNA replication_Homo sapiens_hsa030300.36994656
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36915531
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.35082762
74Fat digestion and absorption_Homo sapiens_hsa049750.34205990
75Phototransduction_Homo sapiens_hsa047440.31320647
76Fanconi anemia pathway_Homo sapiens_hsa034600.29975056
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28169974
78Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.27526184
79Asthma_Homo sapiens_hsa053100.26207858
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25348501
81Vitamin digestion and absorption_Homo sapiens_hsa049770.25111790
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25051730
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24855818
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.24452229
85Mismatch repair_Homo sapiens_hsa034300.24437913
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24249945
87Epstein-Barr virus infection_Homo sapiens_hsa051690.20150244
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19961974
89Glycerolipid metabolism_Homo sapiens_hsa005610.18770273
90Arachidonic acid metabolism_Homo sapiens_hsa005900.18390230
91Nucleotide excision repair_Homo sapiens_hsa034200.15705075
92Rheumatoid arthritis_Homo sapiens_hsa053230.15664549
93Regulation of autophagy_Homo sapiens_hsa041400.15575365
94Chemical carcinogenesis_Homo sapiens_hsa052040.15278098
95Histidine metabolism_Homo sapiens_hsa003400.15162993
96N-Glycan biosynthesis_Homo sapiens_hsa005100.14288091
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.14199979
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.13961983
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.13418550
100Phagosome_Homo sapiens_hsa041450.12285231
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.10294317
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.10004707
103Gastric acid secretion_Homo sapiens_hsa049710.08513855
104HIF-1 signaling pathway_Homo sapiens_hsa040660.08109324
105GABAergic synapse_Homo sapiens_hsa047270.08058031
106Morphine addiction_Homo sapiens_hsa050320.06833136
107Calcium signaling pathway_Homo sapiens_hsa040200.06190676
108Insulin secretion_Homo sapiens_hsa049110.06134804
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.05939016
110Mineral absorption_Homo sapiens_hsa049780.05263928
111Selenocompound metabolism_Homo sapiens_hsa004500.04761112
112Amphetamine addiction_Homo sapiens_hsa050310.04489742
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.03418589
114Retinol metabolism_Homo sapiens_hsa008300.03370095
115Oocyte meiosis_Homo sapiens_hsa041140.02823725
116Steroid biosynthesis_Homo sapiens_hsa001000.02746385
117Spliceosome_Homo sapiens_hsa030400.02541083
118Glucagon signaling pathway_Homo sapiens_hsa049220.01895790
119Insulin signaling pathway_Homo sapiens_hsa049100.01666747
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.00570556
121Nicotine addiction_Homo sapiens_hsa050330.00550343
122Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623-0.0009235
123Homologous recombination_Homo sapiens_hsa03440-0.0009079
124Primary bile acid biosynthesis_Homo sapiens_hsa00120-0.0006583

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »